ORAL HEALTH COMPOSITION AND PREPARATION PROCESS FOR ORAL HEALTH COMPOSITION

Abstract

This patent application refers to oral health composition and preparation process thereof, suitable for direct administration into the oral cavity by specialists or otherwise, wherein the formulations have a wide action spectrum due to self-activation and continuous formation of reactive oxygen, with no need for external activation by light, chemicals or electricity, except for air oxygen, said oral health compositions acting through the synergistic action of air oxygen with octa-carboxy or tetra-carboxy (metal-phthalocyanines) being functional dyes capable of promoting self-activation and continuous production of reactive oxygen in the presence of molecular oxygen in suitable, safe and effective amounts over odor-making substances, microorganisms and over coagulation/healing mechanisms, among other properties of interest for maintenance of oral health, which may be used directly by the patient or by a professional.

Claims

1. “ORAL HEALTH COMPOSITION”, wherein it features a gel composition with the following ingredients: thickeners, moisturizers such as sorbitol, glycerin, polyethylene glycol and/or mixtures thereof, binders such as carboxymethyl cellulose, hydroxyethyl cellulose, xanthan gum, silica, thickener and/or mixtures thereof, conservatives (for example, methylparaben, propylparaben or mixtures thereof), acidifiers (typically phosphoric acid, citric acid, tartaric acid, maleic acid), essences (mint, etc.), flavoring agent (sodium saccharin, or others), said gel composition featuring 30.000% Moisturizer (glycerin, Sorbitol, PEG 600), 10.000% Thickener (Carboxymethyl cellulose, silica), 57.000% Medium (Deionized Water), 0.800% ACTIVE AGENT, 0.100% Sweetener (Sodium saccharin), 1.000% Conservative (Sodium Benzoate), 1.000% Flavoring Agent and 0.100% pH Corrector.

2. “ORAL HEALTH COMPOSITION”, according to claim 1, wherein the active ingredient comprises functional self-activated carboxy-metal-phthalocyanines (octa or tetra).

3. “ORAL HEALTH COMPOSITION”, according to claims 1 and 2, wherein the active ingredient, functional self-activated carboxy-metal-phthalocyanines (octa/tetra), features a concentration varying between 0.001% and 20.000%.

4. “PREPARATION PROCESS FOR ORAL HEALTH COMPOSITION”, of a gel-type composition, wherein it features the following steps: (A) mix and homogenize separately low density carboxymethyl cellulose (CMC), glycerin and/or propylene glycol; (B) solubilize separately sodium saccharine at 20% water and add to mixture A; (C) solubilize separately sodium fluoride at 20% water and add to mixture A; (D) solubilize separately methylparaben and propylparaben at 20% water and add to mixture A; (E) solubilize separately functional self-activated carboxy-metal-phthalocyanines (octa or tetra) in glycerin and add to mixture A; (F) thoroughly and slowly homogenize the mixture at vacuum conditions until all material clusters are removed from the full mixture. (pH 6-8).

5. “ORAL HEALTH COMPOSITION”, wherein it shows a varnish composition with the following ingredients: a base or matrix (natural resins such as colophony or synthetic resins, such as ethyl cellulose or hydroxypropyl methylcellulose), solvent (ethanol, other), fluorinated agents (sodium monofluoride phosphate, titanium tetrafluoride, stannous fluoride, calcium fluoride, amine fluoride, sodium fluoride) and functional self-activated carboxy-metal-phthalocyanines (octa or tetra), said composition featuring 12.000% Matrix, 82.000% Solvent, 2.500% Sodium Fluoride, 1.500% Active Agent and 2.000% Flavoring Agent.

6. “ORAL HEALTH COMPOSITION”, according to claim 5, wherein the matrix concentrations feature concentrations varying between 5.000 and 15.000%.

7. “ORAL HEALTH COMPOSITION”, according to claims 5 and 6, wherein the solvents have concentrations ranging from 70.000% to 90.000%, essence from 0.500% to 1.550% and fluorinated agents added from 0 (zero) to 11,250 ppm.

8. “ORAL HEALTH COMPOSITION” according to claims 5, 6 and 7, wherein the active ingredient, the functional self-activated carboxy-metal-phthalocyanines (octa/tetra), features concentrations ranging from 0.001 to 20.000%, and said antiseptic composition comprising 5.000% Moisturizer (glycerin, Sorbitol, PEG 600), 0.100% Active Agent, 94.000% Medium (Deionized Water), 0.050% Sodium Fluoride, 0.100% Sweetener (Sodium saccharin), 0.100% Conservative (Sodium Benzoate) and 0.500% Flavoring Agent.

9. “PREPARATION PROCESS FOR ORAL HEALTH COMPOSITION”, of a varnish composition, wherein it provides (A) mix and homogenize separately the matrix (artificial resin) and functional self-activated carboxy-metal-phthalocyanines (octa or tetra) to the solvent (ethanol), add to the mixture A sodium fluoride, and thoroughly and slowly homogenize the mixture at vacuum conditions until all material clusters are removed from the full mixture.

10. “ORAL HEALTH COMPOSITION”, wherein it shows an Oral Antiseptic composition with inactive ingredients such as moisturizers such as sorbitol, glycerin, polyethylene glycol and/or mixtures thereof, conservatives (methylparaben, sodium benzoate, propylparaben or mixture thereof), acidifiers (phosphoric acid, citric acid, tartaric acid, maleic acid), essences (mint, etc.), flavoring agents (sodium saccharin or others) and dyes, the active ingredients comprising fluorinated agents (sodium monofluoride phosphate, titanium tetrafluoride, stannous fluoride, amine fluoride, sodium fluoride) and functional self-activated carboxy-metal-phthalocyanines (octa or tetra).

11. “ORAL HEALTH COMPOSITION”, according to claim 10, wherein the concentrations of moisturizing agents vary between 2.000 and 15.000%, and the conservatives used in the composition vary between 0.010 and 0.500%.

12. “ORAL HEALTH COMPOSITION”, according to claims 10 and 11, wherein the active ingredients such as fluorinated agents feature concentrations varying between 0.000 and 450.000 ppm, functional self-activated carboxy-metal-phthalocyanines (octa/tetra) feature a concentration varying between 0.001 and 20.000% of the total composition.

13. “PREPARATION PROCESS FOR ORAL HEALTH COMPOSITION”, of an oral antiseptic composition, wherein it comprises the steps of (A) solubilize separately sodium fluoride at 20.000% water; (B) solubilize separately sodium saccharin at 20.000% water and add to mixture A; (C) solubilize separately methylparaben and propylparaben at 20.000% water and add to mixture A; (D) solubilize separately functional self-activated carboxy-metal-phthalocyanines (octa or tetra) in glycerin and add to mixture A; (E) mix and homogenize separately glycerin and/or propylene glycol to the aroma and add to mixture A; thoroughly and slowly homogenize the mixture at vacuum conditions (pH 6-8), the formula featuring 50.000% to 60.000% Moisturizer (Glycerin, Sorbitol, PEG 600), 8.000% to 12.000% Thickener (Carboxymethyl Cellulose, Silica), 2.000% to 4.900% Medium (Deionized Water), 0.250% to 0.500% Active Ingredient —Anticaries agent (Sodium Fluoride), 0.500% to 1.500% Sweetener (Sodium Saccharin, Xylitol), 0.100% to 0.500% Conservative (Sodium Benzoate), 0.300% to 1.000% Active Ingredient—Anti-Tartar Agent (TSPP), 5.000% to 15.000% Abrasive (Silica), 5.000% to 10.000% Surfactant (Sodium Lauryl Sulphate), 0.100% to 0.300% Antiseptic (Triclosan), 1.000% to 3.000% Flavoring Agent, 0.100% to 0.200% Pigment (Mica), 0.800% to 2.000% pH Corrector (Ortho-Phosphoric Acid) and 0.100% to 1.000% Active Agent.

14. “ORAL HEALTH COMPOSITION”, of a toothpaste composition, wherein it features the following ingredients: Carboxymethyl Cellulose, Glycerin, Deionized Water, Sodium Fluoride, Sodium Saccharin, Sodium Benzoate, Sorbitol, Polyethylene Glycol —PEG 600, Silica, Sodium Lauryl Sulfate, Flavoring Agents.

15. “ORAL HEALTH COMPOSITION”, according to claim 14, wherein it provides a composition of functional self-activated carboxy-metal-phthalocyanines (octa/tetra).

16. “ORAL HEALTH COMPOSITION”, according to claims 14 and 15, wherein the active ingredient, the functional self-activated carboxy-metal-phthalocyanines (octa or tetra), features a concentration varying between 0.000001% and 20%.

17. “ORAL HEALTH COMPOSITION”, according to claims 1, 2, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15 and 16, wherein it features an action based on continuous and localized formation of reactive oxygen, with no need for external activation by light, chemicals or electricity, except for oxygen, by functional self-activated carboxy-metal-phthalocyanines and active agent.

18. “ORAL HEALTH COMPOSITION”, according to claims 1, 2, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16 and 17, wherein said composition, through a synergistic action of oxygen from the air with functional self-activated carboxy-metal-phthalocyanines (octa or tetra), with metals Fe or Co are both administered in the encapsulated form.

19. “ORAL HEALTH COMPOSITION”, according to claims 1 1, 2, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17 and 18, wherein said composition, through a synergistic action of oxygen from the air with functional self-activated carboxy-metal-phthalocyanines (octa or tetra), with metals Fe or Co are both administered in the molecular form.

20. “ORAL HEALTH COMPOSITION”, according to claims 1, 2, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17, 18 and 19, wherein the active agent is associated to the fluorine and calcium complexes and remineralizing phosphate.

21. “ORAL HEALTH COMPOSITION”, according to claims 1, 2, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17, 18 e 19 and 20, wherein the active agent is associated to the bleaching agent.

22. “ORAL HEALTH COMPOSITION”, according to claims 1, 2, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20 and 21, wherein the active agent is associated to the desensitizing agents.

Description

DESCRIPTION OF THE DRAWINGS

[0079] This invention patent application will be described in detail, based on the figures listed below, in which:

[0080] FIG. 1 shows the chemical structure of the active agent, object of this patent, in which the reactive 02 promotes pain reduction, accelerates coagulation and tissue healing, features antimicrobial action, inhibits the formation and removes the biofilm, inhibits formation and removes tartar and, lastly, promotes bleaching, returning the teeth to its natural color;

[0081] FIG. 2 shows the application of Phthalocyanine on the Candida albicans (ATCC 10231) microorganism for 24 hours, using three containers where the first showed positive control, the second provided 10.000 mg Phthalocyanine and the third container showed 1.000 mg Phthalocyanine;

[0082] FIG. 3 shows the application of Phthalocyanine on the Enterococcus Faecalis (ATCC 10231) microorganism for 24 hours, using three containers where the first showed positive control, the second provided 10.000 mg Phthalocyanine and the third container showed 1.000 mg Phthalocyanine;

[0083] FIG. 4 shows the application of Phthalocyanine on the Staphylococcus aureus (ATCC 65381) microorganism for 24 hours, using three containers where the first showed positive control, the second provided 10.000 mg Phthalocyanine and the third container showed 1.000 mg Phthalocyanine;

[0084] FIG. 5 shows the application of Phthalocyanine on the Streptococcus mutans (ATCC 25175) microorganism for 3 minutes, using three containers where the first showed positive control, the second provided 10.000 mg Phthalocyanine and the third container showed 1.000 mg Phthalocyanine; and

[0085] FIG. 6 shows the application of Phthalocyanine on the Streptococcus mutans (ATCC 25175) microorganism for 5 minutes, using three containers where the first showed positive control, the second provided 10.000 mg Phthalocyanine and the third container showed 1.000 mg Phthalocyanine.

DETAILED DESCRIPTION OF THE INVENTION

[0086] This invention refers to a gel composition with the following ingredients: thickeners, moisteners, such as sorbitol, glycerin, polyethylene glycol and/or mixtures thereof, binders such as carboxymethyl cellulose, hydroxyethyl cellulose, xanthan gum, silica, thickener and/or mixtures thereof, conservatives (for example, methylparaben, propylparaben or mixtures thereof), acidifiers (typically phosphoric acid, citric acid, tartaric acid, maleic acid), essence (mint, etc.), flavoring agents (sodium saccharine or others).

[0087] The active ingredient comprises functional self-activated carboxy-metal-phthalocyanines (octa or tetra).

[0088] Concentrations of inactive ingredients are compliant with the market products and will be analyzed on each type of mixture in particular. The active ingredient—functional self-activated carboxy-metal-phthalocyanines (octa or tetra) features concentrations varying from 0.001% to 20.000%.

[0089] Preparation of gel composition: STEP (A): mix and homogenize separately low density carboxymethyl cellulose (CMC), glycerin and/or propylene glycol; STEP (B): solubilize separately sodium saccharine at 20.000% water and add to mixture A; STEP (C): solubilize separately sodium fluoride at 20% water and add to mixture A; STEP (D): solubilize separately methylparaben and propylparaben at 20.000% water and add to mixture A; STEP (E): solubilize separately functional self-activated carboxy-metal-phthalocyanines (octa or tetra) without glycerin and add to mixture A; STEP (F): thoroughly and slowly homogenize the mixture, preferably at vacuum conditions, until all material clusters are removed from the full mixture. (pH 6-8).

TABLE-US-00002 Gel compound Amounts % Moistener (glycerin, Sorbitol, PEG 600) 30.000 Thickener (Carboxymethylcellulose, silica 10.000 Medium (Deionized Water) 57.000 Active Agent 0.800 Sweetener (Sodium Saccharin) 0.100 Preservative (Sodium Benzoate) 1.000 Flavoring Agent 1.000 pH corrector 0.100

[0090] This invention refers to a varnish composition with the following ingredients: a base or matrix (natural resins such as colophony or synthetic resins, such as ethyl cellulose or hydroxypropyl methylcellulose), solvent (ethanol, other), fluorinated agents (sodium monofluoride phosphate, titanium tetrafluoride, stannous fluoride, calcium fluoride, amine fluoride, preferably sodium fluoride) and functional self-activated carboxy-metal-phthalocyanines (octa or tetra). Matrix concentrations, as per composition of this invention, features concentrations that may vary between 5.000% and 15.000%. Solvents comprise concentrations that vary between 70.000 to 90.000% and essence between 0.500% and 1.500%. The fluorinated agents added to this invention feature concentrations that may vary from 0 (zero) to 11,250 ppm.

[0091] The active ingredient, functional self-activated carboxy-metal-phthalocyanines (octa or tetra), features concentrations varying from 0.001% to 20.000%.

[0092] Preparation of varnish composition: STEP (A): mix and homogenize separately the matrix (artificial resin) and functional self-activated carboxy-metal-phthalocyanines (octa or tetra) to the solvent (ethanol); STEP (B): add to the mixture of STEP A sodium fluoride, and homogenize; STEP (C): thoroughly and slowly homogenize the mixture, preferably at vacuum conditions, until all material clusters are removed from the full mixture. Thoroughly and slowly homogenize the mixture, preferably at vacuum conditions, until all material clusters are removed from the full mixture.

TABLE-US-00003 Varnish Composition Amounts % Matrix 12.000 Solvent 82.000 Sodium Fluoride 2.500 Active Agent 1.500 Flavoring Agent 2.000

[0093] This invention refers to a composition of Oral Antiseptic that comprises inactive ingredients such as moisturizers such as sorbitol, glycerin, polyethylene glycol and/or mixtures thereof, conservatives (methylparaben, sodium benzoate, propylparaben, or any mixture thereof), acidifiers (phosphoric acid, citric acid, tartaric acid, maleic acid), essences (mint, etc.), flavoring agents (sodium saccharine or others), dyes. Active ingredients are comprised of fluorinated agents (sodium monofluoride phosphate, titanium tetrafluoride, stannous fluoride, amine fluoride, preferably sodium fluoride) and functional self-activated carboxy-metal-phthalocyanines (octa or tetra). The concentrations of moisturizing agents may vary from 2.000 to 15.000%. Conservatives used in the composition of this invention may vary between 0.010 and 0.500%. Other inactive ingredients shall have its concentration defined according to market needs.

[0094] Active ingredients such as fluorinated agents feature concentrations that may vary between 0.000 and 450.000 ppm. Functional self-activated carboxy-metal-phthalocyanines (octa or tetra) comprise concentrations that may vary between 0.001 to 20.000% of total composition. Other active ingredients such as antimicrobials shall have their concentration defined according to market needs and requirements.

[0095] Preparation of oral antiseptic composition: STEP (A): solubilize separately sodium fluoride at 20.000% water; STEP (B): solubilize separately sodium saccharine at 20.000% water and add to mixture A; STEP (C): solubilize separately methylparaben and propylparaben at 20.000% water and add to mixture A; STEP (D): solubilize separately functional self-activated carboxy-metal-phthalocyanines (octa or tetra) in glycerin and add to mixture A; STEP (E): mix and homogenize separately glycerin and/or propylene glycol to the aroma and add to mixture A; STEP (F): thoroughly and slowly homogenize the mixture, preferably at vacuum conditions. (pH 6-8).

TABLE-US-00004 Antiseptic Composition Amounts % Moistener (glycerin, Sorbitol, PEG 600) 5.000 Active Agent 0.100 Medium (Deionized Water) 94.000 Sodium Fluoride 0.050 Sweetener (Sodium Saccharin) 0.100 Preservative (Sodium Benzoate) 0.100 Flavoring Agent 0.500

[0096] This invention refers to a toothpaste composition with the following ingredients: Carboxymethyl cellulose, Glycerin, Deionized Water, Sodium fluoride, Sodium Saccharin, Sodium Benzoate, Sorbitol, Polyethylene Glycol—PEG 600, Silica, Sodium Lauryl Sulfate, Flavoring Agents.

[0097] The active ingredient comprises functional self-activated carboxy-metal-phthalocyanines (octa or tetra). Concentrations of inactive ingredients are compliant with the market products and will be analyzed on each type of mixture in particular.

[0098] The active ingredient, functional self-activated carboxy-metal-phthalocyanines (octa or tetra), features concentrations varying from 0.001% to 20.000%.

[0099] The process starts with the dissolution preparation of the Active Ingredient—PHTHALO in a moisturizer (Lauryl, Polyethylene Glycol) and then addition to the thickener, forming a pre-mixture of active ingredient/moisturizer/thickener.

[0100] This step occurs under slow stirring, between 45,000 to 200,000 rpm at 25° C., as to prevent formation of clusters, considering that the stirring remains until full dissolution of the ingredients, which lasts around 15 minutes.

[0101] Subsequently, the following components are added in a reactor to be homogenized, for 10 minutes, in a speed and temperature indicated by the equipment manufacturer: Deionized Water, Sodium fluoride, Sodium saccharin and Sodium Benzoate.

[0102] Then, Sorbitol and the Pre-mixture with the previously prepared active ingredient are added to the mixture, to be fully homogenized using a turbine, scraper and fan for 10 minutes, at a speed and temperature indicated by the equipment manufacturer (preferably in vacuum conditions).

[0103] Then, silica is added to the mixture, to be fully homogenized using a scraper and fan for 1 hour and 30 minutes, at a speed and temperature indicated by the equipment manufacturer, and then Triclosan (antiseptic) and Flavoring Agents are added to the mixture, for full homogenization using a scraper for 15 minutes, at a speed and temperature indicated by the equipment manufacturer.

[0104] After obtaining the toothpaste composition, occurred after homogenization of all components, as previously described, the pH correction takes place at a value between 6 and 8; through addition and homogenization of the pH corrector, at a speed and temperature indicated by the equipment manufacturer.

[0105] Subsequently the composition is filled into tubes.

TABLE-US-00005 Formula components Amounts % Moisturizer (glycerin, Sorbitol, PEG 600, 50.000 to 60.000 sodium lauryl sulfate) Thickener (Carboxymethyl cellulose,  8.000 to 12.000 silica) Medium (Deionized Water)  2.000 to 30.000 Active ingredient - Anticaries agent 0.250 to 0.500 (Sodium fluoride) Sweetener (Sodium Saccharin, xylitol) 0.500 to 1.500 Preservative (Sodium Benzoate) 0.100 to 0.500 Abrasive (silica)  5.000 to 15.000 Surfactant (Sodium Lauryl sulfate)  5.000 to 10.000 Antiseptic (Triclosan, Cetylpyridinium 0.100 to 0.300 chloride) Flavoring Agent 1.000 to 3.000 pH corrector (Ortho-phosphoric acid, citric 0.100 to 2.000 acid, sodium phosphate) Active Agent 0.100 to 1.000

[0106] Although the invention is detailed, it is important to understand that its application is not limited to details and steps described herein. The invention is capable of other modalities and to be practiced or performed in a variety of ways. It should be understood that the terminology used herein has descriptive purposes and is not limiting.