PULVURENT EFFERVESCENT TOPICAL TREATMENT COMPOSITION

Abstract

The pulvurent effervescent topical treatment compositions comprise: at least 50% wt. of a gas generating system which comprises both a gas generating constituent as well as a complementary reactive acid constituent, which constituents, when combined in the presence of water or another largely aqueous medium generates a gas, preferably carbon dioxide; 5-50% wt. of an anionic soap and/or anionic surfactant constituent; 0.0001-1.5% wt. of an antimicrobial constituent; 0.0001-3 an exogenous product of Sclerotium rolfsii, and, optionally one or more filler constituents, preferably based on materials which are inert with respect to the gas generating constituent and which also are inert with respect to the antimicrobial constituent; further optionally, one or more further constituents which may be included to provide a desired aesthetic benefit, e.g., a fragrance, colorant and/or a desired technical benefit, e.g. an abrasive, to the pulvurent effervescent topical treatment compositions of which they form a part.

The invention also provides effervescing, foamed topical treatment composition which are used as topical treatment compositions.

Claims

1. A pulvurent effervescent topical treatment composition which comprises: at least 50% wt. of a gas generating system which comprises both a gas generating constituent as well as a complementary reactive acid constituent, which constituents, when combined in the presence of water or another largely aqueous medium generates carbon dioxide; 5-50% wt. of an anionic soap and/or anionic surfactant constituent; 0.0001-1.5% wt. of an antimicrobial constituent; 0.0001-3 an exogenous product of Sclerotium rolfsii, and, optionally one or more filler constituents, based on materials which are inert with respect to the gas generating constituent and which also are inert with respect to the antimicrobial constituent; further optionally, one or more further constituents which may be included to provide a desired aesthetic benefit, e.g., a fragrance, colorant and/or a desired technical benefit, to the pulvurent effervescent topical treatment compositions of which they form a part.

2. A composition according to claim 1 wherein the antimicrobial constituent is selected from: salicylic acid and/or salicylic acid derivatives and/or a salt form thereof.

3. A composition according to claim 1 wherein the antimicrobial constituent is selected from: lactic acid and/or lactic acid derivatives and/or a salt form thereof.

4. A composition according to claim 3 wherein the antimicrobial constituent is an alkyl lactate.

5. A composition according to claim 1 wherein which comprises a cocosulfate anionic surfactant.

6. A composition according to claim 1, wherein the said composition is effective against one or more, preferably at least two or more of, still more preferably at least three of the following microorganisms: E. coli, S. aureus, P. aeruginosa, and E. hirae.

7. A method for providing an antimicrobial benefit to a topical surface, e.g., the epidermis or other body area or hair, which method includes the step of applying an antimicrobially effective amount of a topical germicidal composition according to claim 1 and thereby reduce the incidence of undesired microorganisms present on the treated topical surface, other body surface or hair.

Description

EXAMPLES

[0070] A number of pulvurent effervescent topical treatment compositions were produced by mixing the constituents, each of which was in a comminuted, powered or particulate form, as outlined in Table 1 by adding measured amounts of the individual constituents into an open mouthed vessel, and thereafter manually mixing the constituents until a homogenous mixture resulted. Typically mixing required 5-10 minutes. In the following Table 1, the amounts listed are % wt. of the indicated constituent.

TABLE-US-00001 TABLE 1 E1 E2 E3 E4 E5 E6 E7 cocosulfate 20.0 20.0 20.0 20.0 15.0 14.0 14.0 sodium 60.0 73.2 71.25 59.05 53.0 49.0 49.95 bicarbonate (0.714 mol) (0.871 mol) (0.848 mol) (0.702 mol) (0.631 mol) (0.583 mol) (0.595 mol) citric acid 5.0 5.0 3.0 15.0 30 35.0 35.0 (0.026 mol) (0.026 mol) (0.015 mol) (0.078 mol) (0.156 mol) (0.182 mol) (0.182 mol) salicylic acid 0.3 0.3 0.3 0.3 0.3 0.3 lactic acid 3.35 (60%) dissolvine 0.2 0.2 0.2 0.2 0.4 0.4 0.4 Sclerotium 0.2 1.0 1.0 1.0 1.0 1.0 1.0 Gum silica 4.0 4.0 sodium sulfate 0.15 0.15 talc 14.0 fragrance 0.3 0.3 0.1 0.3 0.3 0.3 0.3

[0071] The identity of the specific constituents are identified on the following Table 2, and were used as supplied from their supplier or source. In addition to the identity of the constituent, the % wt. active and in some instances the source of the constituent is also indicated.

TABLE-US-00002 TABLE 2 cocosulfate sodium cocosulfate,, Mackol CAS-100N, 90-100% wt. active (ex. Rhodia). sodium bicarbonate laboratory grade anhydrous NaHCO.sub.3, 100% wt. active, citric acid laboratory grade anhydrous citric acid, 100% wt. active, salicylic acid laboratory grade anhydrous salicylic acid, 100% wt. active, (ex. Sigma or Aldrich) lactic acid (60%) anhydrous lactic acid on calcium lactate carrier, Purac Powder 60, 60% wt. active acid concentration (ex. Corbion Caravan) dissolvine chelating agent, Dissolvine GL-47-S, tetrasodium glutamate diacetate 100% wt. active (ex. AkzoNobel) Sclerotium Gum exogenous product of Sclerotium rolfsii, 100% wt. active (Amigel, ex. Alban Muller International; Paris, FR) silica anhydrous silica powder, 100% wt. active sodium sulfate anhydrous sodium sulfate, 100% wt. active talc anhydrous sodium sulfate, 100% wt. active fragrance proprietary composition of its supplier, used as 100% wt. active

[0072] Each of the example compositions were essentially dry, free flowing powders which when added to a quantity of water, at a 10% w/w concentration, rapidly effervesced and foamed.

Antimicrobial Testing:

[0073] Compositions E5, E6 and E7 were evaluated for antimicrobial efficacy against two challenge organisms. The compositions were tested according to the following protocol:

[0074] Compositions according to E5, E6 and E7 of Table 1 were produced and used for antimicrobial testing, and stored at room temperature prior to testing.

[0075] For testing, a suitable neutralizer was prepared, by combining 100 g. Tween 80, 30 g lecithin, 5 g sodium thiosulfate, 1 g L-histidine, 10 ml of phosphate buffer to 900 ml of distilled water.

[0076] For testing Tryptic Soy agar, was combined with 7 g/liter of lecithin, and 5 g/liter of Tween 80 and used to culture the challenge organisms after testing.

[0077] For testing, a standardized water sample was prepared by adding CaCO.sub.3 to distilled water to a final concentration of 300 mg/liter. (Known as hard water.)

[0078] The challenge organisms were Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 10536). The microorganisms were a second or third generation subculture on TSA slopes from frozen beads. Subcultures are prepared on TSA slopes (slants) and incubated at 352.5 C. for 18-24 hours. Test cultures were prepared by removing at least two loopfulls of the appropriate TSA slants and the cells were suspended in approximately 10 mL of TSC, and rotated at a rate of 150 rotations/minute for at least three minutes. Thereafter, a portion of the suspended cells was pipetted, and added to an appropriate volume of TSC and the concentrations of the challenge organisms were adjusted to provide 1.5-510.sup.8 cfu/ml for each organism. The concentrations were adjusted according to a known method, e.g. measured utilizing the biolog transmittance; the typical transmittance range of between about 30 and about 50 (biolog) was used for each of the S. aureus (ATCC 6538) and E. coli (ATCC 10536) challenge microorganisms.

[0079] Testing of the test substances was performed according to one of the following Test methods.

[0080] Test 1: 5.55% m/v dilutions of each of the samples tested were prepared using test temperature (37 C.) calibrated hard water to give an in-test dilution of 5%. 9.0 mL aliquots of the diluted test sample were then transferred to sterile tubes for testing. Within 1.5 to 2 minutes after preparation of the test dilution, 1.0 mL of the challenge microorganism (equilibrated to the test temperature) was added to the tube, vortexed and placed back in the temperature controlled waterbath for the duration of the contact time. Two replicates of each of the diluted samples were tested.

[0081] Test 2: 0.56 g of product was added to a sterile test tube, 9.0 mL of test temperature (37 C.) calibrated hard water was added and immediately (within 10 to 20 seconds), 1.0 mL of the challenge microorganism (equilibrated to the test temperature) was added to the tube, vortexed and placed back in the temperature controlled waterbath for the duration of the contact time. (To give an in-test dilution of 5%.) One replicate of each of the diluted samples was tested.

[0082] Note: Upon addition of the standardized water sample to each test tube, during both sets of testing, samples of E5, E6 or E7 were observed to foam spontaneously within the test tube.

[0083] For both tests, the contact time time was 605 seconds contact times whereas samples were subsequently neutralized for 5 minutes and then appropriate dilutions were prepared and then pour plated using the agar previously described. The agar test plates were then incubate at 35-536-5 C. for 48 hours, and then evaluated for the log.sub.10 reduction of the initial challenge organisms present. These results are reported on Table 3, following.

[0084] The results of the test are reported on Table 3.

TABLE-US-00003 TABLE 3 Test 1 Test 1 Test 2 Test 2 S. aureus E. coli S. aureus E. coli (ATCC 6538) (ATCC 10536) (ATCC 6538) (ATCC 10536) Log.sub.10 reduction Log.sub.10 reduction Log.sub.10 reduction Log.sub.10 reduction E5 1.10 0.75 >5.38 0.05 0.99 0.04 E6 1.03 0.06 >5.38 No Reduction 1.74 <0.07 E7 1.76 0.09 >5.38 0.12 1.64 0.13

[0085] As can be seen from the foregoing table, the compositions were particularly effective against S. aureus, a gram positive type microorganism, with lesser but still effective results against E. coli, a gram negative type microorganism.