Coloured keratolytic nail lacquer

Abstract

The present invention provides a liquid nail lacquer composition comprising a pharmaceutically active compound and an aqueous polymer dispersion, wherein said liquid nail lacquer composition forms a film upon drying under standard ambient temperature and pressure; a method for providing the same; and a container comprising said liquid nail lacquer composition.

Claims

1. A liquid nail lacquer composition comprising a pharmaceutically active compound and an aqueous poly (urea-urethane) polymer dispersion for providing a film on a nail of a subject in need thereof, whereby said nail lacquer composition comprises an antimycotic agent, whereby said antimycotic agent is an organic acid selected from the group consisting of lactic acid, malic acid, tartaric acid, citric acid, formic acid, acetic acid, propionic acid, isopropionic acid, oxalic acid, glutaric acid, adipic acid, pyruvic acid and glycolic acid, and wherein said aqueous poly (urea-urethane) polymer dispersion comprises a film forming polymer, whereby said film forming polymer is comprised in said liquid nail lacquer composition in an amount of at least 25 wt. %, relative to the total weight of the composition, as determined according to DIN EN ISO 3251, characterized by further comprising at least one visual control agent in an amount of at least 0.01 wt. %, relative to the total weight of the composition, and at least one keratolytic agent in an amount of at least 0.01 wt. %, relative to the total weight of the composition, whereby said keratolytic agent is a C10-C14 alkyl ester of lactic acid, malic acid, tartaric acid and/or citric acid, wherein the liquid nail lacquer composition has a pH between 2.5 and 6.5, as determined according to DIN ISO 976, and wherein the liquid nail lacquer composition further comprises a plasticizer in an amount of at least 10 wt. %, relative to the total weight of the composition.

2. The liquid nail lacquer composition according to claim 1, whereby said keratolytic agent is comprised in an amount of 0.1 wt. % to 10.0 wt. %, relative to the total weight of the composition.

3. The liquid nail lacquer composition according to claim 1, wherein said liquid nail lacquer composition has a viscosity of at least 250 mPa.Math.s, as determined by DIN EN ISO 3219.

4. The liquid nail lacquer composition according to claim 1, wherein the pH is between 3 and 5.5, as determined according to DIN ISO 976.

5. The liquid nail lacquer composition according to claim 1, wherein said liquid nail lacquer composition is free of magnesium silicate.

6. The liquid nail lacquer composition according to claim 1, whereby said film forming polymer is comprised in said liquid nail lacquer composition in an amount of at least 30 wt. % relative to the total weight of the composition, as determined according to DIN EN ISO 3251.

7. The liquid nail lacquer composition according to claim 1, wherein said polymer has a glass transition temperature lower than −30° C., as determined according to DIN EN ISO 61 006.

8. The liquid nail lacquer composition according to claim 1, having a minimal film forming temperature of at most 5° C., as determined according to DIN EN ISO 2115.

9. The liquid nail lacquer composition according to claim 1, wherein said film has an elongation at break of at least 100%.

10. The liquid nail lacquer composition according to claim 1, wherein said film has a tensile strength at break of at least 5 MPa.

11. The liquid nail lacquer composition according to claim 1, wherein said aqueous poly (urea-urethane) polymer dispersion is a polyether polyurethane polymer dispersion.

12. The liquid nail lacquer composition according to claim 1, wherein said poly (urea-urethane) polymer is an aliphatic poly (urea-urethane) polymer.

13. The liquid nail lacquer composition according to claim 1, whereby said organic acid is selected from the group consisting of lactic acid, malic acid, citric acid, acetic acid, propionic acid, oxalic acid and adipic acid.

14. The liquid nail lacquer composition according to claim 1, whereby said organic acid is acetic acid.

15. The liquid nail lacquer composition according to claim 1, wherein said polymer dispersion has an average particle size d(0.5) between 50 nm and 50 μm, as determined by Coulter laser diffraction.

16. The liquid nail lacquer composition according to claim 1, wherein the aqueous poly (urea-urethane) polymer dispersion comprises one or both of polyurethane-A and polyurethane-B, wherein the polyurethane-A is a copolymer of 1,4-butanediol, ethylene diamine, hexamethylene diisocyanate, isophorone diisocyanate, and sodium N-(2-aminoethyl)-3-aminoethane sulfonate monomers, and wherein the polyurethane-B is a copolymer of adipic acid, dicyclohexylmethane diisocyanate, ethylenediamine, hexanediol, neopentyl glycol and sodium N-(2-aminoethyl)-3-aminoethanesulfonate monomers.

17. A treatment method for nail diseases comprising providing the liquid nail lacquer composition according to claim 1.

18. A method of preparing a liquid nail lacquer composition according to claim 1, comprising the steps of mixing at least a pharmaceutically active compound being an organic acid selected from the group consisting of lactic acid, malic acid, tartaric acid, citric acid, formic acid, acetic acid, propionic acid, isopropionic acid, oxalic acid, glutaric acid, adipic acid, pyruvic acid and glycolic acid and an aqueous (urea-urethane) polymer dispersion, and optionally one or more adjuvants.

19. A container comprising a liquid nail lacquer composition according to claim 1.

20. The container according to claim 19, wherein said container is provided with a plug and a brush for applying said liquid nail lacquer composition to a subject.

Description

EXAMPLES

(1) In the following examples are intended to further clarify the present invention, and are nowhere intended to limit the scope of the present invention.

Example 1

(2) The current embodiment provides a liquid nail lacquer composition or paste which can be applied on skins or nails of a patient, which paste composition then solidifies to provide a release layer comprising an antimycotic agent to be released in the skin or nail. After one day, the dried composition can easily be removed as a peel-off layer.

(3) A peel-off nail lacquer composition with anti-mycotic activity is presented below. The lacquer is predominantly comprised of an aliphatic poly (urea-urethane) polymer dispersion, further comprising water as a viscosity modifier and an antimycotic agent, acetic acid. A complete list of ingredients and their amounts is provided in Table 1.

(4) The poly (urea-urethane) polymer dispersion is a 50 wt. % polymer dispersion comprising polyurethane-A as a poly (urea-urethane) polymer. Polyurethane-A is a copolymer of 1,4-butanediol, ethylene diamine, hexamethylene diisocyanate, isophorone diisocyanate, and sodium N-(2-aminoethyl)-3-aminoethane sulfonate monomers. The 50 wt. % polyurethane-A dispersion is a colloidal system of a high molecular weight (>50.000 Dalton) poly (urea-urethane) polymer dispersed in water. An internal emulsifier is incorporated into the polymer backbone to ensure stability of the dispersion. Therefore, the use of external surfactants may not be required. This polymer was found to perform exceptionally well as a film former in nail lacquer applications according to the invention. The film is very strong and adhesive, but also elastic. These properties allow combination of strong nail adhesion and easy removal. In addition, the occlusive film will enhance hydration of the nail, which in turn stimulates diffusion of acetic acid (polar substance) through the nail. Furthermore, it causes no irritation or redness on the surrounding skin.

(5) The composition showed to be a good-flowing, smooth, homogeneous phase. Upon application of a 1-2 mm thick film to a subject, the film dried within a period of 3 to 4 minutes.

(6) TABLE-US-00001 TABLE 1 Nail lacquer composition according to the invention. ingredient content (wt. %) acetic acid 3.00 peppermint oil 3.00 octyl gallate 0.50 sorbitan sesquioleate 1.00 phenethyl alcohol and ethyl hexyl glycerin 0.50 1,2-hexanediol and caprylyl glycol 1.00 dehydroacetic acid and benzyl alcohol 1.10 polysorbate 80, cetyl acetate, acetylated lanolin alcohols 0.50 iodopropinyl butylcarbamate (0.01%) 0.15 biotin 0.01 water 9.24 poly (urea-urethane) polymer dispersion 80.00

(7) Acetic acid, CH.sub.3COOH, also known as ethanoic acid acts as acidifying agent. Its small size and its hydrophilic properties enables it to penetrate the nail quickly and lower the pH efficiently. Furthermore, its low molecular weight means there are more acid molecules per weight unit, meaning it will take more alkaline substance to neutralize it than larger acids (such as propionic acid or lactic acid). This enables the acid to keep the pH low for a longer period of time, when taking into account the same compensatory production or liberation of alkaline products. This small acid penetrates the nail and lowers the pH of the nail plate, thus preventing fungal development. Although dermatophytes are not necessarily alkaliphilic, they cannot grow under continuous acidic conditions.

(8) Peppermint oil is added as fragrance and solvent for different ingredients. Second to this, the inventors have found that penetration capacity is enhanced by inclusion of peppermint oil. Furthermore, it masks the odour of the included organic acids.

(9) Synergistic blend of 1,2-hexanediol and 1,2-octanediol and has different functions: conditioning, emollient, humectant, solvent and preservative booster.

(10) Polysorbate 80, cetyl acetate, acetylated lanolin alcohols is a solubilized acetylated lanolin alcohol derivative in a concentration of 0.5 to 5.0%. It is a mixture of polysorbate 80, cetyl acetate, stearyl acetate, oleyl acetate and acetylated lanolin alcohol. It is a surface active agent and stabilizes the formulation. It is also a superfatting agent to help to prevent dryness of the skin surrounding the nail.

(11) Octyl gallate is the ester of 1-octanol and gallic acid which has an antioxidant activity. The anti-oxidative effect of octyl gallate is important to maintain the characteristics of the peppermint oil and other oxidation-sensitive ingredients by inhibiting oxidative degradation. This allows optimal preservation of the oil-dissolved ingredients and to maintain fragrance properties of the oil.

(12) Dehydroacetic acid or 3-acetyl-6-methyl-2H-pyran-2,4-(3H)-dione (DHA) is added as a preservative and a plasticizer. The addition to the composition allows to form a strong but peelable poly (urea-urethane) polymer film, with strong adhesion to the nail.

(13) Benzoic acid serves as bacteriostatic preservative. During use, the water-based formula is continuously exposed to fungi (and bacteria), present on the human nail. Indeed, the product is daily applied using a brush for a long time, as curing period can take more than one year, depending on the initial status of the nail infection. The high concentration of water in the formula is an ideal environment to promote microbial growth, which can strongly affect product's efficacy, or even worse, negatively impact nail condition. For these reasons, the product must be properly preserved. Benzoic acid is present in the composition to inhibit bacterial growth therein.

(14) Iodopropynyl butylcarbamate (IPBC) is used as a preservative. Although DHA is already included in the formulation to prevent fungal contamination, IPBC is included to increase the preservative potency of the formulation. It is known that some surfactants may have an impact on the preservative effects of DHA. In order to circumvent this, IPBC was added.

(15) Phenethyl alcohol is an antimicrobial preservative, which is active at pH 6 or lower. Ethyl hexyl glycerin is combined with synergistic blend of 1,2-hexanediol and caprylyl glycol, DHA, benzoic acid, and IPBC. Ethyl hexyl glycerin is added in combination with phenethyl alcohol. It boosts the preservative of the latter but also has tissue conditioning properties. Activity of DHA and phenethyl alcohol can be affected by the presence of nonionic detergents. For this reason, the combination of preservatives allows optimal preservation of the paste composition, as the product is daily prone to bacterial and fungal contamination.

(16) Biotin, also known as vitamin B.sub.7, vitamin H or coenzyme R is necessary for cell growth, the production of fatty acids, isoleucine and valine. It also plays a role in gluconeogenesis. Biotin assists in various metabolic reactions involving the transfer of carbon dioxide. As the nails that are suffering from onychomychosis are very brittle and dull, biotin helps to reestablish the growth of a healthy nail by supporting the cell metabolism. This allows the nail to cure faster and to be less prone to reinfection.

(17) The composition was successfully applied for the treatment of fungal nail infections. No negative side effects were observed.

Example 2

(18) The current embodiment provides a liquid nail composition according to the invention. Table 2 provides a description of the ingredients of the composition according to Example 2.

(19) The polyurethane-B dispersion is a 41 wt. % polymer dispersion comprising polyurethane-B as a poly (urea-urethane) polymer. Polyurethane-B is a copolymer of copolymer of adipic acid, dicyclohexylmethane diisocyanate, ethylenediamine, hexanediol, neopentyl glycol and sodium N-(2-aminoethyl)-3-aminoethanesulfonate monomers. The polyurethane-B dispersion is a colloidal system of a high molecular weight polyurethane polymer dispersed in water. This polymer functions as a universal film former for high and low viscosity. It can be incorporated into oil-in-water and water-in-oil emulsions as well as in multiple emulsions, gels and gel creams. The polymer structure contains both hydrophilic and hydrophobic segments, which impart a unique combination of water resistance and ease of removal from skin. The polyurethane-B dispersion imparts non-transfer resistant properties to decorative cosmetics. Also, its film creates a natural soft feel.

(20) TABLE-US-00002 TABLE 2 Nail lacquer composition according to Example 2. ingredient content (wt. %) acetic acid 3.00 eucalyptus oil 2.00 octyl gallate 3.00 synergistic blend of 1,2-hexanediol and caprylyl glycol 0.50 dehydroacetic acid 0.60 TWEEN ® 80 1.00 iodopropynyl butylcarbamate 0.15 ethanol 6.00 polyurethane-A dispersion, 50 wt. % 41.87 polyurethane-B dispersion, 41 wt. % 41.87

(21) TWEEN® 80 is a POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80, and can be identified by CAS number 9005-65-6.

(22) The composition according to Table 2 showed to provide a smooth, homogeneous, viscous, while liquid. The film obtained upon drying of the liquid on the treated nail showed to have good scratch resistance and could be peeled off as one layer. The composition was applied for the treatment of fungal nail infections.

Example 3

(23) The current embodiment provides a liquid nail composition according to the invention. Table 3 provides a description of the ingredients of the composition according to Example 3.

(24) TABLE-US-00003 TABLE 3 Nail lacquer composition according to Example 3. ingredient content (wt. %) acetic acid 3.00 eucalyptus oil 2.00 octyl gallate 3.00 synergistic blend of 1,2-hexanediol and caprylyl glycol 0.50 dehydroacetic acid 0.60 TWEEN ® 80 1.00 iodopropynyl butylcarbamate 0.15 2-phenoxyethanol 1.00 ethanol 5.00 polyurethane-A dispersion, 50 wt. % 41.87 polyurethane-B dispersion, 41 wt. % 41.87

(25) The composition according to Table 3 showed to provide a smooth, homogeneous, viscous, white liquid. The film obtained upon drying of the liquid on the treated nail showed to have good scratch resistance and could be peeled off as one layer. The composition was applied for the treatment of fungal nail infections.

Example 4

(26) The current embodiment provides a liquid nail composition according to the invention. Table 4 provides a description of the ingredients of the composition according to Example 4.

(27) TABLE-US-00004 TABLE 4 Nail lacquer composition according to Example 4. ingredient content (wt. %) acetic acid 3.00 eucalyptus oil 2.00 octyl gallate 1.33 synergistic blend of 1,2-hexanediol and caprylyl glycol 1.00 dehydroacetic acid 0.60 TWEEN ® 80 0.67 xantham gum 0.50 iodopropynyl butylcarbamate 0.15 2-phenoxyethanol 1.00 water 9.75 polyurethane-A dispersion, 50 wt. % 80.00

(28) The composition according to Table 4 showed to provide a homogeneous, highly viscous, white liquid. The composition was applied for the treatment of fungal nail infections.

Example 5

(29) The current embodiment provides a liquid nail composition according to the invention. Table 5 provides a description of the ingredients of the composition according to Example 5.

(30) TABLE-US-00005 TABLE 5 Nail lacquer composition according to Example 5. ingredient content (wt. %) acetic acid 3.00 eucalyptus oil 2.00 octyl gallate 1.33 synergistic blend of 1,2-hexanediol and caprylyl glycol 1.00 dehydroacetic acid 0.60 TWEEN ® 80 0.67 xantham gum 0.50 iodopropynyl butylcarbamate 0.15 2-phenoxyethanol 1.00 water 9.75 polyurethane-B dispersion, 41 wt. % 80.00

(31) The composition according to Table 5 showed to provide a homogeneous, highly viscous, white liquid. The composition was applied for the treatment of fungal nail infections.

Example 6

(32) The current embodiment is a pigmented liquid nail composition according to the invention. Table 6 provides a description of the ingredients of the composition according to Example 6.

(33) TABLE-US-00006 TABLE 6 Nail lacquer composition according to Example 6. ingredient content (wt. %) glycolic acid 3.00 eucalyptus oil 2.00 octyl gallate 1.33 synergistic blend of 1,2-hexanediol and caprylyl glycol 1.00 dehydroacetic acid 0.60 TWEEN ® 80 0.67 xantham gum 0.50 iodopropynyl butylcarbamate 0.15 FD&C Red #40 6.00 water 4.75 polyurethane-B dispersion, 41 wt. % 80.00

(34) The composition according to Table 6 is a homogeneous, highly viscous, red liquid. Glycolic acid is added as an acidifying agent. FD&C Red #40 is added as a colouring agent. The composition is applied for the treatment of fungal nail infections.

Example 7

(35) The current embodiment is a liquid nail composition according to the invention. Table 7 provides a description of the ingredients of the composition according to Example 7.

(36) TABLE-US-00007 TABLE 7 Nail lacquer composition according to Example 7. ingredient content (wt. %) pyruvic acid 3.00 eucalyptus oil 2.00 octyl gallate 1.33 synergistic blend of 1,2-hexanediol and caprylyl glycol 1.00 dehydroacetic acid 0.60 TWEEN ® 80 0.67 xantham gum 0.50 iodopropynyl butylcarbamate 0.15 2-phenoxyethanol 1.00 1,2,3-propanetriol triacetate 9.75 polyurethane-A dispersion, 50 wt. % 80.00

(37) The composition according to Table 7 is a homogeneous, highly viscous, white liquid. Pyruvic acid is added as an acidifying and exfoliating agent. 1,2,3-propanetriol triacetate is added as a plasticizing agent. The composition was applied for the treatment of fungal nail infections.

Example 8

(38) The current embodiment is a liquid nail composition according to the invention. Table 8 provides a description of the ingredients of the composition according to Example 8.

(39) TABLE-US-00008 TABLE 8 Nail lacquer composition according to Example 8. ingredient content (wt. %) acetic acid 3.00 eucalyptus oil 2.00 octyl gallate 1.33 synergistic blend of 1,2-hexanediol and caprylyl glycol 1.00 dehydroacetic acid 0.60 TWEEN ® 80 0.67 xantham gum 0.50 pyruvic acid 0.50 iodopropynyl butylcarbamate 0.15 2-phenoxyethanol 0.50 water 9.75 polyurethane-B dispersion, 41 wt. % 80.00

(40) The composition according to Table 8 is a homogeneous, highly viscous, white liquid. Pyruvic acid is added as an exfoliating agent. The composition is applied for the treatment of fungal nail infections.

Example 9

(41) The current embodiment is a liquid nail composition according to the invention. Table 9 provides a description of the ingredients of the composition according to Example 9.

(42) TABLE-US-00009 TABLE 9 Nail lacquer composition according to Example 9. ingredient content (wt. %) lactic acid 3.00 eucalyptus oil 2.00 octyl gallate 1.33 synergistic blend of 1,2-hexanediol and caprylyl glycol 1.00 dehydroacetic acid 0.60 TWEEN ® 80 0.67 xantham gum 0.50 iodopropynyl butylcarbamate 0.15 ethyl lactate 3.00 water 7.75 polyurethane-B dispersion, 41 wt. % 80.00

(43) The composition according to Table 9 is a homogeneous, highly viscous, white liquid. Ethyl lactate is added as a nail penetration enhancing agent. The composition is applied for the treatment of fungal nail infections.

Examples 10-19

(44) Table 10 provides a description of the ingredients of the compositions according to Example 10-19.

(45) TABLE-US-00010 TABLE 10 Nail lacquer compositions according to Examples 10-19. ingredient EX. 10 .sup.a EX. 11 .sup.a EX. 12 .sup.a EX. 13 .sup.a EX. 14 .sup.a EX. 15 .sup.a EX. 16 .sup.a EX. 17 .sup.a EX. 18 .sup.a EX. 19 .sup.a polyurethane-B dispersion, 41 0 0 0 0 0 0 0 0 0 60 wt. % polyurethane-A dispersion, 50 80 80 80 80 80 80 80 80 80 0 wt. % water 6.29 6.79 6.04 8.04 8.29 7.89 5.89 5.89 5.89 14.64 hydroxyethylcellulose 0 0 0 0 0 0 0 0 0 0.5 xanthan gum 0.25 0.25 0.5 0.5 0.25 0.25 0.25 0.25 0.25 0 glycerol 0 0 0 0 0 0 0 0 0 0 acetic acid 3 3 3 3 3 3 3 3 3 3 pyruvic acid 0 0 0 0 0 0 0 0 0 0.5 sodium hydroxide 1M 0 0 0 0 0 0 0 0 0 10 iodopropinylbutylcarbamate 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 (0.01 wt. %) peppermint oil 0.1 0.1 0.1 0.1 0.1 3 3 3 3 1 octyl gallate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 sorbitan sesquioleate 1 1 1 1 1 1 1 1 1 1 polysorbate 80, cetyl acetate, 3 0.5 3 3 3 0.5 0.5 0.5 0.5 0.5 acetylated lanolin alcohols dehydroacetic acid and benzyl 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 alcohol phenethyl alcohol and ethyl 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 hexyl glycerin 1,2-hexanediol and caprylyl 1 1 1 1 1 1 1 1 1 1 glycol biotin 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 C12-C13 alkyl lactate 0.5 2.5 0.5 0.5 0.5 0.5 0.5 0 0 2 di C12-C13 alkyl malate 0 0 0 0 0 0 0 0.5 0 1 di C12-C13 alkyl tartrate 0 0 0 0 0 0 0 0 0.5 0 red dye .sup.b 3 3 3 1 1 1 1 1 1 1 pink pigment .sup.c 0 0 0 0 0 0 2 2 2 2 .sup.a expressed as percentage by weight (wt. %). .sup.b CI 12490 (34-38%), glycerine, water, sodium laureth sulphate. .sup.c boron nitride, 98.5%.

Comparative Example 20

(46) Table 11 provides a description of the ingredients of the composition according to Comparative Example 20.

(47) TABLE-US-00011 TABLE 11 Nail lacquer composition according to Comparative Example 20. ingredient content (wt. %) acetic acid 3.00 decylene glycol 2.00 octyl gallate 3.00 dehydroacetic acid 0.60 iodopropynyl butylcarbamate 0.30 2-phenoxyethanol 1.00 ethanol 45.00 polyurethane-A dispersion, 50 wt. % 45.10

(48) The composition according to Table 11 showed a thick, cloudy, not-incorporated, heterogeneous solid in a liquid phase. The composition proved not applicable as a nail lacquer or as a nail lacquer for treatment of nail diseases.

Comparative Examples 21-26

(49) Table 12 provides a description of the ingredients of the compositions according to Comparative Examples 21-26.

(50) TABLE-US-00012 TABLE 12 Nail lacquer compositions according to Examples 21-26. ingredient EX. 21 .sup.a EX. 22 .sup.a EX. 23 .sup.a EX. 24 .sup.a EX. 25 .sup.a EX. 26 .sup.a polyurethane-B dispersion, 41 wt. % 0 60 60 60 60 60 polyurethane-A dispersion, 50 wt. % 80 0 0 0 0 0 water 8.24 17.74 17.54 16.69 16.49 22.04 hydroxyethyl cellulose 0 0 0.2 0 0 0.5 xanthan gum 0 0 0 0.05 0.25 0 glycerol 0 0 0 1 1 0 acetic acid 3 3 3 3 3 3 pyruvic acid 0 0.5 0.5 0.5 0.5 0.5 sodium hydroxide 1M 0 10 10 10 10 10 iodopropinylbutylcarbamate 0.15 0.15 0.15 0.15 0.15 0.15 (0.01 wt. %) peppermint oil 3 3 3 3 3 0.1 octyl gallate 0.5 0.5 0.5 0.5 0.5 0.1 sorbitan sesquioleate 1 1 1 1 1 0.5 polysorbate 80, cetyl acetate, 0.5 0.5 0.5 0.5 0.5 0.5 acetylated lanolin alcohols dehydroacetic acid and benzyl alcohol 1.1 1.1 1.1 1.1 1.1 1.1 phenethyl alcohol and ethyl hexyl glycerin 0.5 0.5 0.5 0.5 0.5 0.5 1,2-hexanediol and caprylyl glycol 1 1 1 1 1 0 biotin 0.01 0.01 0.01 0.01 0.01 0.01 C12-C13 alkyl lactate 0 0 0 0 0 0 di C12-C13 alkyl malate 0 0 0 0 0 0 di C12-C13 alkyl tartrate 0 0 0 0 0 0 red dye .sup.b 1 1 1 1 1 0 pink pigment .sup.c 0 0 0 0 0 1 .sup.a expressed as percentage by weight (wt. %). .sup.b CI 12490 (34-38%), glycerine, water, sodium laureth sulphate. .sup.c boron nitride, 98.5%.

(51) The compositions according to Table 12 showed a thick, cloudy, not-incorporated, heterogeneous solid in a liquid phase. The compositions proved not applicable as a nail lacquer or as a nail lacquer for treatment of nail diseases.