Peroxymonosulfate Whitening Strips

Abstract

The present disclosure provides a tooth whitening strip comprising a hydratable adhesive film comprising an inorganic salt of peroxymonosulfate. preferably an alkali metal salt or alkaline carth metal salt, or mixtures thereof, and methods of using the same.

Claims

1. A hydratable adhesive film for a tooth whitening strip, the hydratable adhesive film comprising: a polymer matrix consisting of water-soluble or water-swellable polymers, the water-soluble or water-swellable polymers selected from the group consisting of polyvinylpyrrolidone polymer and a polyethylene glycol polymer; a whitening agent comprising an inorganic salt of peroxymonosulfate, the inorganic salt of peroxymonosulfate being dispersed in the hydratable adhesive film; and a buffering agent.

2. The hydratable adhesive film according to claim 1, wherein the polymer matrix is present in an amount from about 40 to about 99 wt. %, based on the total weight of the hydratable adhesive film.

3. The hydratable adhesive film according to claim 1, wherein the polymer matrix is present in an amount from about 50 to about 95 wt. %, based on the total weight of the hydratable adhesive film.

4. The hydratable adhesive film according to claim 1, wherein the inorganic salt of peroxymonosulfate comprises sodium peroxymonosulfate, potassium peroxymonosulfate, ammonium peroxymonosulfate, or a combination thereof.

5. The hydratable adhesive film according to claim 1, wherein the inorganic salt of peroxymonosulfate is potassium peroxymonosulfate.

6. The hydratable adhesive film according to claim 1, wherein the strip is free of hydrogen peroxide.

7. The hydratable adhesive film according to claim 1, wherein the peroxymonosulfate salt is present in an amount from about 0.1 to about 5 wt. %, based on the total weight of the hydratable adhesive film.

8. The hydratable adhesive film according to claim 1, wherein the hydratable adhesive film is a single-layer hydratable adhesive film.

9. The hydratable adhesive film according to claim 1, wherein the buffering agent is present in an amount from about 0.1 to about 5 wt. %, based on the weight of the hydratable adhesive film.

10. A tooth whitening strip comprising: a single-layer hydratable adhesive film comprising: a polymer matrix consisting of water-soluble or water-swellable polymers, the water-soluble or water-swellable polymers selected from the group consisting of polyvinylpyrrolidone polymer and a polyethylene glycol polymer, and a whitening agent comprising an inorganic salt of peroxymonosulfate, the inorganic salt of peroxymonosulfate being dispersed in the hydratable adhesive film; and a backing layer, the single-layer hydratable adhesive film being disposed on the backing layer.

11. The tooth whitening strip according to claim 10, wherein the tooth whitening strip provides whitening of a tooth for a period of time of at least 10 minutes.

12. The tooth whitening strip according to claim 10, wherein the tooth whitening strip has a pH of about 5 to 9 when the tooth whitening strip is hydrated.

13. The tooth whitening strip according to claim 10, wherein the backing layer comprises polyethylene, polypropylene, polyvinyl chloride, polyvinyl acetate, polymethyl methacrylate, polytetrafluoroethylene, polyesters, polyimides, polycarbonates, or a combination of two or more thereof.

14. The tooth whitening strip according to claim 10, wherein the backing layer comprises a coated paper, a wax paper, or a combination thereof.

15. The tooth whitening strip according to claim 10, wherein the tooth whitening strip has a thickness of about 0.1 to about 5 mm.

16. The tooth whitening strip according to claim 10, wherein the polymer matrix is present in an amount from about 40 to about 99 wt. %, based on the total weight of the hydratable adhesive film.

17. The tooth whitening strip according to claim 10, wherein the peroxymonosulfate salt is present in an amount from about 0.1 to about 5 wt. %, based on the total weight of the hydratable adhesive film.

18. The tooth whitening strip according to claim 10, wherein the whitening agent further comprises a peroxide, a chlorite, a hypochlorite, chlorine dioxide, or a combination thereof.

19. A method for whitening teeth, the method comprising: wetting a tooth whitening strip according to claim 10 with water, saliva, or an assisting solvent; optionally, removing the backing layer from the single-layer hydratable adhesive film; and affixing a surface of the single-layer hydratable adhesive film to a tooth.

20. The method according to claim 19, wherein the single-layer hydratable adhesive film is affixed to the tooth for about 10 to about 60 minutes.

Description

EXAMPLES

[0078] Exemplary embodiments of the present disclosure will be illustrated by reference to the following examples, which are included to exemplify, but not to limit the scope of the present invention.

[0079] In the examples and elsewhere in the description of the invention, chemical symbols and terminology have their usual and customary meanings. Temperatures are in degrees Celsius unless otherwise indicated. The amounts of the components are in weight percent based on the standard described; if no other standard is described then the total weight of the composition is to be inferred. Various names of chemical components include those listed in the CTFA International Cosmetic Ingredient Dictionary (Cosmetics, Toiletry and Fragrance Association, Inc., 7.sup.th ed. 1997).

Example 1

Exemplary MPS-Based Whitening Strip

[0080] Potassium peroxymonosulfate is combined with a polymer matrix in an aqueous solution or suspension and mixed until homogenous. The resulting viscous or gel-like solution or suspension is then formed into a thin-layer film on an inert, plastic backing, such as polyethylene or polypropylene. The film is dried to remove water, followed by affixation of a removable protective backing, and cutting into strips.

[0081] The final dried strips have a composition as follows:

TABLE-US-00003 Ingredient in Film Weight of Dry Film % Polyvinylpyrrolidone PVP, PVP 40-80% (e.g., 60%) Vinyl Acetate, and/or Polyoxazoline Carbomer (Carbopol 971) or 0-10% (e.g., 5%) Polyacrylic acid Polyoxypropylene- 0-30% (e.g., 24%) Polyoxyethylene Block Copolymer and/or PEG 600 Polyphosphates (e.g., sodium or 1-5% (e.g., 2%) potassium pyrophosphates) Potassium MPS triple salt 1-10% (e.g., 2.2% (2KHSO.sub.5KHSO.sub.4K.sub.2SO.sub.4) (1% MPS)) Sweeteners 1-3% (e.g., 1.8%) Flavor 1-3% (e.g., 2%) Total 100

[0082] Other final strips may be prepared according to the same or similar method, providing, for example, strips having the following composition:

TABLE-US-00004 Ingredient in Film Weight of Dry Film % PVP, PVP-VA, PO, PAA, PEG- 40-95% (e.g., 75-90%) PPG copolymer (e.g., poloxamer), HEC, HPC, HPMC, CMC, and/or PEG Polyphosphates (e.g., sodium or 1-5% (e.g., 2%) potassium pyrophosphates) Potassium MPS Triple Salt 0.5-10% (e.g., 2-2.2%) (2KHSO.sub.5KHSO.sub.4K.sub.2SO.sub.4) (0.25-5% MPS, e.g., 1% MPS) Sweeteners 0.5-5% (e.g., 1.8%) Flavors 0.5-5% (e.g., 2%) Total ca. 100

[0083] The invention has been described above with reference to illustrative Examples, but it is to be understood that the invention is not limited to the disclosed embodiments. Alterations and modifications that would occur to one of skill in the art upon reading the specification are also within the scope of the invention, which is defined in the appended claims.