HAND-HELD PIPETTING DEVICE

Abstract

The invention relates to a pipetting device with a touch screen and a system comprising said pipetting device. The operating concept of this pipetting device provides that values of pipetting parameters can be set by the user on at least one input screen page, that actuation of the actuating element leads to the display of an output screen page and to the start of a pipetting operation defined according to the pipetting parameters, and that touching a separate input field of the output screen page leads back to an input screen page.

Claims

1. A hand-held pipetting device for pipetting at least one liquid sample, comprising a connecting section for connecting at least one pipetting container, an electrically controlled moving member for aspirating the at least one sample into the at least one pipetting container, holding the sample in the at least one pipetting container, and discharging sample from the at least one pipetting container when performing a pipetting operation, with a touch-sensitive screen for entering the parameter values of user-definable pipetting parameters, where a parameter set of pipetting parameters completely defines the pipetting operation, with an electrical control device comprising a data processing device programmed to control the moving member in dependence on the at least one pipetting parameter, with at least one actuating element which can be actuated by a finger pressure of a user and whose actuation starts the pipetting operation defined according to the parameter set, characterized in that the data processing device is programmed to, display in the screen an input screen page (100; 100; 100; 100_1; 100_3; 100_4) for displaying and entering pipetting parameters of a parameter set of pipetting parameters, and, when the actuation of the at least one actuating element is detected, displaying in the screen, instead of the input screen page, an output screen page (200; 200; 200; 200_1) for displaying pipetting parameters of the parameter set defined in the input screen page, and, when this actuation of the at least one actuating element is detected or upon the subsequent actuation of one of these actuating elements, starting the pipetting operation defined according to this pipetting parameter set, wherein said output screen page or a subsequently displayed output screen page includes a special button (201; 201; 201; 201_1), touching of which causes the output screen page to be closed and said input screen page or another input screen page to be displayed on the screen.

2. The hand-held pipetting device according to claim 1, wherein the pipetting device comprises precisely one first and one second actuating element, which are operable separately from one another, in particular by an operating rocker, wherein the data processing device is programmed to detect, starting from the display of the input screen page, the actuation of the first actuating element by the user and to start the pipetting operation defined according to the parameter set.

3. The hand-held pipetting device according to claim 1, wherein the pipetting device comprises an operating rocker, and comprises a first and a second actuating element which are operable separately from one another by the operating rocker, in that pressing a first pressure surface of the operating rocker actuates the first actuating element and pressing a second pressure surface of the operating rocker actuates the second actuating element, wherein the first and second pressure surfaces are haptically distinguishable.

4. The hand-held pipetting device according to claim 1, wherein the pipetting device comprises a housing which is arranged as a handle for holding the pipetting device with a single hand of the user and which comprises an axial portion containing the moving member, along the longitudinal axis of which the moving member extends, and wherein the pipetting device comprises a first and a second actuating element, which are operable separately from one another by an operating rocker, which is mounted on a thumb support surface, which is arranged at an angle 100<<150 to the longitudinal axis and is arranged in particular inclined downwards.

5. The hand-held pipetting device according to claim 1, wherein the data processing device is programmed to execute a recorder function, in which the GUI comprises at least one input field for starting and/or ending a recording and, after the start, the steps of a pipetting program for carrying out a pipetting operation defined by the user are recorded, wherein the user carrying out these steps by actuating the at least one actuating element and by inputting values of the pipetting parameters in one or more input screen pages.

6. The hand-held pipetting device according to claim 1, wherein the pipetting device comprises a housing with an axial portion containing the moving member, along the longitudinal axis of which the moving member extends, and a head portion comprising a front surface inclined to the longitudinal axis, formed by the surface of the screen and a frame enclosing the screen, the screen occupying at least 80% of the front surface; and wherein in particular a frame front surface lies in a first plane and the screen lies in a second plane identical to or parallel to the first plane.

7. The hand-held pipetting device according to claim 1, comprising a housing with a connecting section for at least one pipetting container and with an ejector button, the contact surface of which is movable along a path into the housing by pressing the ejector button, the pipetting device is configured such that, when the end of this path is reached, the ejection of the pipetting container, in particular of the pipette tip, is executed or that an electrical signal is generated which triggers the ejection of the at least one pipetting container.

8. The hand-held pipetting device according to claim 1, wherein the data processing device is programmed to, display in the screen a screen page including at least one first input tile displaying the value of at least one first pipetting parameter and touching of which opens an input interface allowing the user to enter the value of the at least one first pipetting parameter, wherein said input interface is a screen area in which a numeric keypad is displayed, the numeric keys of which are individually touchable and usable by the user to enter a sequence of digits defining the value of the at least one first pipetting parameter.

9. The hand-held pipetting device according to claim 1, wherein the data processing device is programmed to, display in the screen a screen page for displaying the pipetting parameters of a parameter set of pipetting parameters, wherein the screen page includes at least one first input tile that displays the value of at least one first pipetting parameter of a base parameter set, and touching the input tile opens an input interface that allows the user to enter the value of the at least one first pipetting parameter, wherein the screen page contains an input field, the touching of which causes the display of a selection list containing a list of short descriptions of further selectable pipetting parameters, from which the user can select at least one second pipetting parameter, which is added to the at least one first pipetting parameter of the basic set, in order to define with this the pipetting parameters of the parameter set of pipetting parameters determining the pipetting operation, wherein, after the selection of the at least one second pipetting parameter is completed, the selection list is closed and the screen page is displayed which now also displays, in addition to the at least one first input tile, at least one second input tile which displays the value of the at least one second pipetting parameter and the touching of which opens an input interface which enables the user to enter the value of the at least one second pipetting parameter.

10. The hand-held pipetting device according to claim 1, wherein the data processing device is programmed to, if the value entered by a user via an input interface for a pipetting parameter is invalid, information is displayed on the screen and preferably at least one correction button is displayed, the touching of which, either instead of the value entered by the user, automatically performs at least one correction operation, which may have the following embodiments: instead of the invalid value, a valid value is automatically set; at least one pipetting parameter alternative to the said pipetting parameter is selected and, in particular, is occupied by the value of the user or another suitable value; it will undo the user's input and, in particular, allow it to be re-entered; and/or an error message is output; and/or the change of the previously current value is ignored and the previously current value is kept; and/or another non-combinable pipetting parameter representing a non-combinable function is automatically deselected.

11. The hand-held pipetting device according to claim 1, wherein the data processing device is programmed to, display in the screen a screen page showing one or more input tiles extending in particular substantially over the entire screen page.

12. The hand-held pipetting device according to claim 1, wherein the data processing device is programmed to, display in the screen a start screen page, which is replaced by a second screen page by a sideways swipe gesture, and which is replaced by a third screen page by a sideways opposite swipe gesture, wherein in particular the second screen page comprises a list of input fields, wherein each input field comprises a short designation and wherein touching the input field loads a predetermined parameter set defining a predetermined pipetting operation, wherein in particular after touching this input field a further screen page is displayed; and wherein in particular the third screen page comprises a list of input fields, wherein each input field comprises a short designation and wherein touching the input field loads a historical parameter set, used in the past and automatically stored, which defines a historical pipetting operation, wherein in particular after touching this input field another screen page is displayed.

13. A system for input of pipetting parameters, comprising the hand-held pipetting device according to claim 1, and an external data processing device comprising an external screen and data processing device programmed to display in the external screen an external input screen page for displaying and inputting the pipetting parameters of a parameter set of pipetting parameters, wherein the external input screen page and the input screen page of the pipetting device are substantially the same in content, wherein the system is configured to transmit the pipetting parameters defined on the external data processing device to the pipetting device and to use them there to define a pipetting operation.

14. A computer program code for providing an input screen page on the screen of a hand-held pipetting device for pipetting at least one liquid sample and having a connecting section for connecting at least one pipetting container, an electrically controlled moving member for aspirating the at least one sample into the at least one pipetting container, for holding the sample in the at least one pipetting container, and for dispensing sample from the at least one pipetting container when performing a pipetting operation, and a touch-sensitive screen for inputting the parameter values of user-definable pipetting parameters, wherein a parameter set of pipetting parameters completely defines the pipetting operation, and wherein the pipetting device has an electrical control device with a data processing device which is programmed to control the moving member as a function of the at least one pipetting parameter, and at least one actuating element which can be actuated by a finger pressure, in particular thumb pressure, of a user and whose actuation starts the pipetting operation defined according to the parameter set, wherein the program code, when executed by the data processing device of the hand-held pipetting device, results in a) an input screen page for displaying and entering pipetting parameters of a parameter set of pipetting parameters is displayed in the screen, b) when the actuation of the at least one actuating element is detected, an output screen page for displaying pipetting parameters of the parameter set is displayed in the display screen, and optionally: upon this actuation or a subsequent actuation of an actuating element, the pipetting operation is also started according to the current pipetting parameter set, and c) a special button is displayed in the output screen page, the touching of which causes the output screen page to be closed and a screen page, in particular an input screen page, to be displayed in the screen.

Description

[0169] Further preferred embodiments of the method according to the invention, the hand-held piston-stroke pipette, the data processing device cooperating therewith, the system and the computer program will result from the following description of the embodiment examples in connection with the figures and their description. Identical components of the embodiments are indicated by substantially the same reference signs, unless otherwise described or otherwise apparent from the context. It shows:

[0170] FIG. 1a shows a schematic side view of an example of a pipetting device according to the invention, in this case an air cushion pipette.

[0171] FIG. 1b shows a detail of the operating rocker of the pipetting device from FIG. 1a.

[0172] FIG. 1c shows a view of the pipetting device from FIG. 1a rotated slightly around the longitudinal axis A.

[0173] FIG. 1d shows a perspective side view of a detail of the pipetting device from FIG. 1a, with visible touchscreen.

[0174] FIG. 1e schematically shows a system according to the invention according to an embodiment example.

[0175] FIG. 2a shows, by means of two images of the header area of a pipetting device according to an embodiment of the invention, the functionality of the GUI of the pipetting device to switch between two main types of screen pages, namely between an input screen page and an output screen page.

[0176] FIG. 2b shows input screen pages of the GUI and below them (symbolically) an actuating element of the pipetting device starting from an input screen page (set), which is replaced by an output screen page by actuating the actuating element, which-respectively whose content-changes successively in the dispensing pipetting operation (Dis) shown here.

[0177] FIG. 2c shows an input screen page of the GUI, with a short description list of the currently selected list of pipetting parameters for the pipetting parameter set, where the short description list is implemented in the form of tags arranged at the top of the screen, in each of which a short description of the selected pipetting parameters is shown; in this way, the user has the already selected pipetting parameters in view, even if he does not see the entire (scrollable) selection list.

[0178] FIG. 2d shows an input screen page, in particular home screen, of the GUI and a parameter selection screen page superimposed on the input screen page when a separate input field on the input screen page is touched.

[0179] FIG. 2e shows an output screen page of the pipetting device according to embodiment, in a multi-step dispensing operation, in a first state in substep i=2 and a second state in substep i=3.

[0180] FIG. 2f shows an output screen of the pipetting device according to the embodiment of the invention, during a multi-step pipetting operation.

[0181] FIG. 3a shows two images of the header area of a pipetting device according to the embodiment of the invention to illustrate further functionalities of the GUI of the pipetting device, namely starting from a home screen via a selection list in the selection screen to add further pipetting parameters or functions to the current parameter set.

[0182] FIG. 3b shows two images of a pipetting device according to an embodiment of the invention to illustrate further functionalities of the GUI of the pipetting device, namely adding further pipetting parameters or functions to the current parameter set starting from a home screen with scrollable content or a scrollable selection list.

[0183] FIG. 4 shows, on the basis of several images of the screen of a pipetting device according to the embodiment, the functionality of the GUI of the pipetting device to switch between the display of different screen pages.

[0184] FIG. 5a shows by means of several images of the screen of a pipetting device according to the embodiment of the invention the functionality of the GUI of the pipetting device to set pipetting parameter values by means of an input mask.

[0185] FIG. 5b shows by means of two images of the screen of a pipetting device according to the invention according to an embodiment the functionality of the GUI of the pipetting device to call up a historical list of pipetting parameters or to use an optional menu bar with input fields or, as a navigation aid, information fields not serving as input fields for the input screen page.

[0186] FIG. 6 shows, on the basis of several images of the screen of a pipetting device according to the embodiment, the functionality of the GUI of the pipetting device to select predetermined parameter sets representing specific application scenarios.

[0187] FIG. 7a shows two images of the screen of a pipetting device according to the invention according to an embodiment the functionality of the GUI of the pipetting device to mark a current parameter set as a favorite, which is then stored as a favorite and displayed in particular in a favorite screen page as a selectable list entry, namely as a correspondingly informative input tile.

[0188] FIG. 7b shows two images of the screen of a pipetting device according to the invention according to an embodiment the functionality of the GUI of the pipetting device, that the input tile identifying a favorite parameter set in the favorite screen page has an input field, the touching of which transfers the parameters of the favorite parameter set to a separate screen, which is then displayed, in which the parameter values and/or the parameter selection of the favorite parameter set can be changed.

[0189] FIGS. 8a and 8b belong together and show, by means of a sequence of numerous images of the screen with the actuating element of a pipetting device according to the invention (symbolically) superimposed thereunder, the functionality of the GUI of the pipetting device to define the pipetting parameters of a user-defined pipetting operation by means of a recorder function of the pipetting device.

[0190] FIG. 9 shows, on the basis of a sequence of numerous images of the screen with the actuating element of a pipetting device according to the invention (symbolically) displayed below it, the functionality of the GUI of the pipetting device to select a parameter set created in a user-defined manner by means of the recorder function and to edit it for modification purposes.

[0191] FIG. 1a shows the hand-held pipetting device according to the invention for pipetting at least one liquid sample, in this case an air cushion pipette 1, comprising: a connecting section 2 for connecting at least one pipetting container 19, in this case a pipette tip, [0192] with a moving member electrically controlled by the control device 5, in this case the piston 3, for aspirating the at least one sample into the at least one pipetting container 19, holding the sample in the at least one pipetting container and dispensing sample from the at least one pipetting container when carrying out a pipetting operation, [0193] with a touch-sensitive screen 4 on the front surface 14a of the head section 14 of the pipetting device, for inputting the parameter values of user-definable pipetting parameters, wherein a parameter set of pipetting parameters completely defines the pipetting operation, [0194] wherein the electrical control device 5 comprises a data processing device 6 programmed to control the moving member 3 in response to the at least one pipetting parameter, and comprises a data memory 7 and a communication unit 8 for wireless communication with an external data processing device, [0195] with exactly two actuating elements (synonymously: actuation elements) 9a and 9b, which can be actuated by the user by means of an operating rocker 10. Each of these actuating elements can be actuated to move the pipetting device from an input mode (set), in which an input screen page 100, 100 is shown in the screen, e.g. the home screen shown in FIG. 1d, to an output mode (do), in which an output screen page is shown in the screen. This advantageous aspect of the operating concept is also explained with reference to further FIGS. 2a, 2b and 4. In contrast, actuation of the ejector button 15 and a (not shown) power on/off button of the pipetting device do not cause the change between set and do mode. The list of pipetting parameters belonging to the parameter set can be edited by means of the input field 101, also referred to as extra button, which is provided with a + sign in FIG. 1d.

[0196] The operating rocker comprises a lower section 10b, which is concave and whose actuation activates the button 9b and, in particular, effects a sample delivery, and an upper section 10a, which is convex and whose actuation activates the button 9a and, in particular, effects a sample pick-up. The operating rocker sits on a plateau formed by a housing section that makes an angle of approximately =130-140 with the longitudinal axis A of the pipetting device. Due to the hand support 16 arranged perpendicular to the longitudinal axis next to the plateau, the pipetting device fits ergonomically in the hand, and the thumb can rest on the rocker 10 at rest, since the hand position allows the thumb to rest on a sweet spot of the hand. The screen 4 is disposed in a head housing portion 14 of the pipetting device.

[0197] The pipetting device comprises an electric motor 18 which is powered by an accumulator 17 and which moves the piston rod or piston 3 within the cylinder piston 12 so that an aspiration pressure or a dispensing pressure is the result in the pipetting channel 13. Precise dispensing can be achieved by means of the electronic control system. An ejector button 15 is provided to allow ejection of the pipette tip 19 from the connecting section 2 by means of an ejection sleeve of the pipetting device. In particular, the data processing device is programmed to abort an ongoing pipetting operation in the event of actuation of the ejector button 15 and to replace any output screen page still displayed by an input screen page 100, 100.

[0198] An actuation of any of the two actuating elements 9a, 9b by the user would start the pipetting operation defined according to the current parameter set. The selection of the pipetting parameters of a parameter set which defines the desired semi-automated pipetting operation and the setting of the values of these pipetting parameters is performed by means of a GUI which implements the particular operating concept according to the invention. This operating concept is explained with reference to the following figures.

[0199] The data processing device 6 is programmed (see FIG. 2a) to display in the screen 4 an input screen page 100, 100 (set, see contents of the rectangle enclosed by the dashed line) for displaying and inputting pipetting parameters of a parameter set of pipetting parameters, and, when an actuation of at least one of the actuating elements 9a or 9b is detected, to display in the screen 4 an output screen page 200 (do) for displaying pipetting parameters of the parameter set defined in the input screen page, and furthermore, when this actuation of the at least one actuating element is detected or during the subsequent actuation (in the sense of an optional safety query) of one of these actuating elements, to start the pipetting operation defined according to this pipetting parameter set, wherein the output screen page 200, or another output screen page displayed after the output screen page 200, has an input area designed as a special button 201 (here labeled with the information back), here at the lower edge of the screen, touching of which causes the output screen page 200 to be closed and the input screen page 100 or another screen page, in particular input screen page, to be displayed in the screen 4. In particular, a second actuation of one of the actuating elements 9a, 9b (different from the screen) following this first actuation starts the pipetting operation defined according to the current pipetting parameter set.

[0200] The other screen page mentioned can in particular enable editing of parameter values contained in the pipetting parameter set. It does not have to be exactly the previous input screen page 100 if, for example, only the speed is to be quickly adjusted when the pipetting sequence (do) has already started. It can be provided that also not all parameter values can be changed/corrected after the pipetting operation has started, but only certain parameter values of the current pipetting parameter set.

[0201] The input screen page 100 and the output screen page 200 differ in their graphical and/or textual or numerical reproduction, in particular in the color scheme: the input fields of the input screen page 100 are largely kept with black information (letters, numerical values, input field color) on a light or white background, and the display fields of the output screen page 200 are largely kept with blue information on a light or white background. The black input field 101 (also referred to as the extra button) of the input screen, which calls up the selection screen for selecting pipetting parameters, does not exist in the output screen page.

[0202] In particular, the output screen 200 will display different contents, preferably depending on the substep of an automated multi-step pipetting operation currently taking place, in particular the values of the pipetting parameters currently defining the substep, e.g. the dispensing of a subvolume Vt at a specific dispensing speed v2 as substep i of a total of N steps of the pipetting operation. This can be the case, for example, in the Dis application scenario shown in FIG. 2b.

[0203] In FIG. 2b, an input screen page 100_1 is initially displayed, which contains the pipetting parameter set of a dispensing process running in a partially automated manner; the extra button 101_1, which is graphically slightly modified here compared to the extra button 101, enables the pipetting parameter list to be edited in an analogous manner. Actuation of the actuating element, namely here of the switch 9a or first pressure surface 10a of the operating rocker 10, leads the pipetting device from the set mode to the Do mode; the output screen page 200_1 is now displayed, which contains the special button 201_1, which is graphically modified compared to the special button 201 and otherwise acts analogously.

[0204] After an executed aspiration process, e.g. after a period of 2 seconds here, in which the sub-step of aspirating 360 l of solution into the pipetting container is executed, the output screen page 200_1 displays the output screen belonging to the sub-step of dispensing the first dispensing sub-volume of 120 l. An actuation of the actuating element, in this case the second pressure surface 10b of the operating rocker 10, initiates the dispensing of the partial volume, each further actuation of the pressure surface 10b leads to the next dispensing substep. The dispensing substeps are counted through by index counter i=1 . . . 3, the progress display i/N (i=1 . . . 3; N=3) shows the progress of the semi-automatic dispensing process in an output field on the output screen page. To make the progress even more intuitive for the user to understand, a variable display element can be used, e.g., the display roller shown in FIGS. 2e and 2f. The output screen page 200_1 does not have such a changeable display element, the output tiles are here always at the same position of the output screen page 200_1, only the numerical display of the parameter values changes as well as the progress display.

[0205] FIG. 2e shows an output screen page 200 of the pipetting device according to embodiment, in a multi-step dispensing process, in a first state in sub-step i=2 (left side of the figure) and a second state in sub-step i=3 (right side of the figure). The dispensing screen has a variable display element 203, which is implemented as a display roller. In the case of a variable display element comprising at least one output tile, in particular the position of at least one output tile within the display element changes. The display roller 203 has a central output tile 203a that displays the pipetting parameter partial dispensing volume with the value 200 l of an (N=6)-step dispensing process, the dispensing speed 8 and a numerical progress indicator (2/6). Above adjacent to the center dispensing tile 203a is displayed the top dispensing tile 203b which displays Dispense 200 l of the previous dispensing sub-step (i=1), and below adjacent to the center dispensing tile 203a is displayed the bottom dispensing tile 203c which displays Dispense 200 l of the dispensing sub-step (i=3) immediately following the current sub-step i=2. On the right side in the picture, the same output screen 200 is shown, which is displayed during the next dispense sub-step with i=3. Above adjacent to the center output tile 203a is displayed the top output tile 203b which displays Dispense 200 l of the previous dispense sub-step (i=2), and below adjacent to the center output tile 203a is displayed the bottom output tile 203c which displays Dispense 200 l of the dispense sub-step (i=4) immediately following the current sub-step i=3. The transition of the view of the display element 203 from i=2 to i=3 (left to right) may be animated to illustrate the dynamics of the progress. The changing display element makes the perception of the multi-step pipetting operation and the operation of the pipetting device more intuitive. In the case of the last partial dispensing step (i=N; here i=6), either information about reaching the end or other information is displayed in the lower position 203c of the display roller, nothing is displayed, or the corresponding output tile 203c is then not displayed at all. Analogous can be provided in the first partial output step i=1 for the upper output tile 203b, which then e.g. either shows nothing or is omitted.

[0206] The display roller here has a horizontal rotation axis, and the position change of the output tiles is in a vertical direction. Alternatively, a vertical rotation axis or oblique rotation axis would be possible.

[0207] FIG. 2f shows an output screen page 200 of the pipetting device according to the embodiment example, in a multi-step (M=32) pipetting operation, in a state in sub-step i=8. Here, too, a display roller 203 is shown, which has the middle output position or output tile 203a, the upper output tile 203b and the lower output tile 203c, which operate analogously to the display roller 203. In addition, the output screen 200 has further functionality achieved by means of further output fields and input fields. Preferably, an output screen page in particular does not have an input field that shows the value of a pipetting parameter and whose touching would enable changing a pipetting parameter in the next step, as implemented in the present embodiments. In the Do mode present during the display of an output screen page, changing pipetting parameters is not possible, and at most is possible via intermediate steps, and not all pipetting parameters of the parameter set are changeable. For example, it may be possible to change the speed of dispensing/aspiration of the liquid during an ongoing multi-step pipetting operation.

[0208] The output screen page 200 has an input field arranged at the edge, here at the bottom right, which bears the inscription Pause and implements a pause function. Touching this input field pauses the multi-step pipetting operation, here for example after completion of the dispensing sub-step i=1 of N=3, which is at the same time the eighth sub-step of a total 32-step programmed pipetting operation. The input field provided with the exclamation mark and the circulating arrow enables the repetition of a pipetting operation in the event that the eighth sub-step just performed must be repeated, e.g. due to a user error. According to the logic of the GUI, the input fields mentioned are therefore not input fields which show the value of a pipetting parameter and whose touching would enable a pipetting parameter to be changed in the next step.

[0209] In these embodiments of the pipetting device, touching an input field always results in an immediate effect, i.e., the effect occurs without significant delay and preferably without another screen page being displayed between the time of touching and the time of displaying the effect (e.g., opening an input interface), e.g., as an information page that indicates a delay, also referred to as a waiting page. However, there may be GUI scenarios in which such an intermediately displayed information page is useful.

[0210] As shown in FIG. 2f, for a multi-step (here M=32) pipetting operation, a progress bar can be useful to graphically illustrate the progress (8/32) also displayed numerically here. The note Protocol Lisa 250 in the output tile 222 indicates that an e.g. individually programmed pipetting operation with the user-defined designation Lisa 250 is being carried out and simultaneously logged, i.e. stored e.g. in a log file of the pipetting device. As generally provided, the special button 201 leads to closing the output screen page 200. In general, in particular, each output tile is not an input tile, accordingly does not have an input field, the touching of which would result in a function, and accordingly does not allow any input.

[0211] The concept of distinguishing between an input screen page and an output screen page, which is implemented by means of external distinguishability, forms a significant ergonomic advantage in operation, since the user can recognize with a minimum of effort whether he is currently in apossibly interrupted, waiting for actuationpipetting operation or in a setting mode. Accordingly, the concept of the input screen page and the output screen page implies such an input mode and output mode of the pipetting device that are easily distinguishable by the user. Preferably, only touching the separate input area (special button)or a completed pipetting operation, which can cause an automatic return to an input screen page, in particular home screen,allow the user to make a change of parameter values or to make a parameter selection again. This separation especially prevents accidental changing of parameter values while the do mode is running, which could destroy a lab work if necessary and cause considerable loss of value. On the other hand, the change from set to do mode by pressing the actuating element means considerable convenience for the user and is intuitively understandable. This also contributes significantly to ergonomics and an efficient workflow. An output screen page (e.g., 200) is preferably characterized in principle by the fact that the display fields or tiles contained in the output screen page, e.g., the output tile 203, are purely informative, i.e., they do not serve as input fields and touching them does not result in any action, in particular, does not start any input option. This does not apply to a separate control panel of the output screen page, in this case of the special button 201, the touching of which cancels the output mode and leads to the display of an input screen page on the screen and, in particular, can lead to the termination of a pipetting operation or pipetting program that may currently still be running.

[0212] The pipetting device 1 comprises precisely a first 9a and a second actuating element 9b, which can be actuated separately from one another, in particular by an operating rocker 10. The data processing device 6 is programmed to detect the actuation of the first or second actuating element 9a or 9b by the user and to start the pipetting operation defined according to the parameter set.

[0213] The pipetting device comprises the operating rocker 10, and the first 9a and the second actuating element 9b, which can be actuated separately from one another by the operating rocker 10 in that pressing a first pressure surface 10a of the operating rocker 10 actuates the first actuating element 9a and pressing a second pressure surface 10b of the operating rocker actuates the second actuating element 9b, the first and second pressure surfaces being haptically distinguishable. In particular, the first pressure surface 10a is convex (=curved outward), and the second pressure surface 10b is concave. This allows the user to feel the desired actuating element or the desired side (pressure surface) of the operating rocker without visual inspection, and operation is intuitive and ergonomic.

[0214] The pipetting device 1 comprises a housing 11, which is configured as a handle for holding the pipetting device with a single hand of the user, and which has an axial section 11 containing the moving member, along whose longitudinal axis A the moving member 3 runs. The operating rocker is mounted on a thumb support surface arranged at an angle 80<<1800, namely here preferably =100-150, preferably 130 to the longitudinal axis and in particular arranged inclined downwards. Down refers to an orientation of the pipetting device with the longitudinal axis A aligned vertically and the pipette tip 19 pointing in the direction of gravity. The angular arrangement of the plateau section of the operating rocker results in an ergonomically arranged thumb support surface. The thumb support surface is arranged starting from the longitudinal axis and is in particular perpendicular to a plane passing through the longitudinal axis A and perpendicular to a surface of the planar screen 4. The position of the plateau section, which is at the same height as the hand support in relation to the longitudinal axis, also results in the advantageous ergonomics.

[0215] The head section 14 comprises the front surface 14a inclined to the longitudinal axis A, which is formed by the surface of the screen 4 and a frame enclosing it, whereby the screen here takes up about 80% of the front surface; the frame front surface 14a lies in a first plane and the planar screen 4 lies in a second plane identical to the first plane. As a result, even edge areas of the screen can be easily touched by the user, and the available area of the touchscreen 4 can thus be optimally used. At the same time, the screen edges are not exposed and are protected by the frame front surface 14a.

[0216] The housing 11 comprises the connecting section 2 (working cone) for at least one pipetting container 19 and the ejector button 15, the contact surface of which can be moved along a path into the housing by pressing the ejector button, the pipetting device configured such that when the end of this path is reached the ejection of the pipetting container, in particular of the pipette tip, takes place or so that an electrical signal is generated which triggers the ejection of the at least one pipetting container.

[0217] FIG. 5a: The data processing device is programmed to display in the screen a screen page 102 including at least a first input tile 103, here 103a, 103b, 103c, indicating the value of at least a first pipetting parameter (here: 103a: V=120 l, 103b: v=(v1, v2) with dispensing speed v1=step 8, recording speed=step 8; number n of steps n=3) and touching of which opens an input interface which allows the user to enter the value of the at least one first pipetting parameter, this input interface being a screen area in which, in particular, a numeric keypad is displayed, the numeric keys of which can be touched individually and can be used by the user to enter a sequence of digits which defines the value of the at least one first pipetting parameter. The input tiles are here white rectangular areas of the screen, which are recognizable by corresponding drawing or contrasting with the gray background, and extend with their width b over almost the entire width B of the screen 4. This results in advantageous ergonomics. Although this applies to the input tiles mentioned, it need not apply to all input fields of the input screen page, see FIG. 1d. Here, the input interface is the screen area in a new screen page 100a shown on the right in FIG. 5a, which is shown as superimposed on the screen page 100. Similar screen areas 100b, 100c open when input tiles 103b, 103c of the associated pipetting parameters v=(v1, v2) and n are opened. Or correspondingly a screen area with input fields in a list with possible fractions f=0.1 to 1.0, if instead of the absolute number the division of the total volume V (e.g. by dispensing steps into partial steps or partial volumes) is to be set.

[0218] FIG. 3a: Particularly preferably, the data processing device 6 is programmed to display in the screen 4 a screen page 100, here implemented as a home screen, for displaying the pipetting parameters of a parameter set of pipetting parameters, wherein the screen page includes at least one first input tile 103 (here three input tiles 103a, 103b, 103c), which displays the value of at least one first pipetting parameter of a base parameter set (here: V, v=(v1, v2), n) and whose touching an input interface, here in FIG. 5a e.g. the screen area with numeric keypad of the screen page 100a, which allows the user to enter the value of the at least one first pipetting parameter, wherein the screen page 100 contains an input field 101, the touching of which causes the display, here in a separate screen page 110, in a selection list, which contains a list of short descriptions (here: quick mix, reverse, step time, auto blow off etc.) of further pipetting parameters (here: v=(v1, v2, n), etc.).)) of further selectable pipetting parameters (here: qm, rev, st, abo etc.), from which the user can select at least one second pipetting parameter (here qm, rev, st, or abo etc.) which corresponds to the at least one second pipetting parameter (here qm, rev, st, or abo etc.).), which is added to the at least one first pipetting parameter of the base parameter set, in order to define with this the pipetting parameters of the parameter set of pipetting parameters determining the pipetting operation, wherein, after the selection of the at least one second pipetting parameter has been completed, the selection list is closed and the screen page 100 is displayed again, which now also displays, in addition to the at least one first input tile 103, at least one second input tile which displays the value of the at least one second pipetting parameter (in this case qm, rev, st, or abo etc.) and the touching of which triggers an input of at least one second pipetting parameter (in this case qm, rev, st, or abo etc.).) and the touching of which opens an input interface 100d etc. which allows the user to enter the value of the at least one second pipetting parameter.

[0219] As an alternative to the display of an alternative screen page 110 in which the selectable parameters are shown, from which one returns to the home screen 100 after selecting/deselecting the desired parameters by touching the input field 104, the contents of the home screen can also be, as shown in FIG. 3b. e.g. by a downwardly extended area 106 accessible by scrolling (vertical wiping or tapping on the control panel 105) or even further areas, in which the possible pipetting parameters are listed and can be selected/activated, and subsequently their values can also be edited.

[0220] Said invention provides a particularly advantageous aspect of the innovative operating concept of a pipetting device. From user studies it became known to the inventors that for a significant fraction of users a more efficient workflow can be produced with a pipetting device in which the user defines the desired pipetting operations mostly according to his own wishes by adding pipetting parameters, i.e, functions or features, to an existing, e.g. a proven parameter set or a base parameter set. This approach obviously leads optimally efficiently to the goal of defining an individually desired pipetting operation. In particular, if a base parameter set is provided on a screen, especially a home screen, which is immediately executable, a sense of achievement in operation is immediately provided without the need for lengthy study of operating instructions. Within a short learning time, users orient themselves in the list of possible pipetting parameters, and thus more efficiently exploit the potential of the great functionality of an electric pipetting device. This is especially true for the large group of users who, with known prior art pipetting devices, have difficulty learning existing-more or less complex-operating modes representing application scenarios, and then settle for the simplest operating modes. The novel concept invites inexperienced users to learn functions and offers full flexibility to experienced users.

[0221] Preferably, the data processing device 6 is programmed to, when the value for a pipetting parameter entered by a user via an input interface 100a, 100b, 100c, 100d is invalid, display an information on the screen and preferably [0222] at least one correction button is displayed, the touching of which, either instead of the value entered by the user, automatically performs at least one correction operation, which may have the following embodiments: [0223] a permissible value is automatically set instead of the impermissible value; [0224] at least one pipetting parameter alternative to the said pipetting parameter is selected and, in particular, occupied by the value of the user or another suitable value; [0225] User's input is undone and, in particular, re-entry is enabled;
and/or [0226] an error message is output;
and/or [0227] the change of the previously current value is ignored and the previously current value is kept;
and/or [0228] another non-combinable pipetting parameter representing a non-combinable function is automatically deselected.

[0229] Preferably, the data processing device 6 is programmed to display on the screen 4 a screen page 100 displaying a list of input tiles 103a, 103b, 103c, in particular extending over substantially the entire screen page.

[0230] FIG. 4: The data processing device 6 is programmed to display in screen 4 a start screen 120 and which is replaced by a laterally opposite swipe gesture by a third screen page 130, wherein in particular (cf. FIG. 6) the second screen page 120 has a list of input fields, wherein each input field has a short designation (here e.g. the input tile with the short designation measure volume) and wherein touching the input field loads a predetermined parameter set which defines a predetermined pipetting operation, wherein in particular after touching this input field a further screen page 120a is displayed; and wherein in particular the third screen page 130 has a list with input fields, wherein each input field has a short designation (here e.g. the input tile with the short designation measure volume). for example the input tile with the short designation 150 l steps 6 etc.) and wherein the touching of the input field loads a historical, in the past used and automatically stored, parameter set which defines a historical pipetting operation, wherein in particular after touching this input field another screen page is displayed.

[0231] In FIG. 1e the system 300 for inputting pipetting parameters is shown, comprising the handheld pipetting device 1 an external data processing device 50 having an external screen 51 and a data processing device 52 programmed to display in the external screen an external input screen page for displaying and inputting the pipetting parameters of a parameter set of pipetting parameters, wherein the external input screen page and the input screen page of the pipetting device are substantially the same in content, the system being arranged to transfer the pipetting parameters defined on the external data processing device to the pipetting device and to use them there to define a pipetting operation.

[0232] FIG. 7a uses two images of an input screen page 100_3 of a pipetting device according to the embodiment example to show the functionality of the GUI of the pipetting device to mark a current parameter set as a favorite, which is then stored as a favorite and displayed in particular in a favorite screen page as a selectable list entry, namely as a correspondingly informative input tile. An input field correspondingly marked with a favorite symbol (asterisk) detects a user touch here, on the basis of which a pipetting parameter set defined in the input screen page 100_3 is stored as a favorite, which is illustrated by the color change of the favorite symbol.

[0233] FIG. 7b shows, on the basis of two screen pages of a pipetting device according to the invention according to an embodiment example, the functionality of the GUI of the pipetting device, that the input tile identifying a favorite parameter set in the favorite screen page 121 has an input field, the touching of which transfers the parameters of the favorite parameter set to the home screen, namely the input screen page 100_4, which is then displayed, in which the parameter values and/or the parameter selection of the favorite parameter set can be changed.

[0234] FIGS. 8a and 8b belong together and show, on the basis of a sequence of numerous images of the screen with an actuating element (symbolically) superimposed below it, the functionality of the GUI of the pipetting device according to an embodiment to define the pipetting parameters of a user-defined pipetting operation by a recorder function of the pipetting device. In FIG. 8a, a programming operation performed by the user starts from a screen page titled Programs, which has already been described as an autoprogram set screen page. By means of an input field + on this screen page another program can be created. Then, here on a following screen page, an input field record is offered, whose touching starts the recorder function and/or the recording. As it were, a separate recorder mode of the pipetting device is started, in which, here in the example, the actuation of the actuating elements (9a, 9b) does not lead to the electrical movement of the piston 3; rather, a pipetting operation is only simulated (but this could also be carried out in a non-simulated manner), and the program steps are recorded. A feature of the recorder function is that only the actuating elements 9a, 9b, which serve to pick up and dispense the sample, as well as the touch screen and its input tiles 103, which serve to set pipetting parameter values, on input screen pages 100 etc. are necessary. No programming by means of programming code is required. During recording, a status bar on the screen displays the information that recording is in progress (Recording . . . ). In addition, an input field with a stop character is provided, with which the recording can be stopped. The automatically assigned name Program 2 is displayed in the program list of the Programs screen page as an input tile; touching it allows editing the program, especially changing its name.