<i>Elsholtzia ciliata </i>essential oil extract as antiarrhythmic drug

Abstract

The present invention provides a new formulation which includes Elsholtzia ciliata Extract. Experiments have shown that ECE decreases the rate of depolarization of upstroke of myocardial action potential, slows the propagation of electrical excitation and distributes the ECG QRS range, i.e. treats the heart as a first-class anti-arrhythmic drug. Due to its herbal origin, the ECE can be well tolerated and widely used as a safe drug for eliminating cardiac arrhythmias.

Claims

1. A method for treating a human patient for cardiac arrythmias comprising the steps of: extracting dried leaves of Elsholtzia ciliata herb by hydrodistillation; mixing an amount of 10-80 ml of said Elsholtzia ciliata oil extract with 10-80 ml emulsifier polysorbate 20; adding 20-80 mL pure water and mixing to form an anti-arrythmic composition; and administering the anti-arrythmic composition to the human patient for treating and preventing cardiac arrhythmias.

2. The method of claim 1, wherein e step of mixing to perform the anti-arrythmic composition is performed for about 2 minutes to 3 minutes using a magnetic stirrer.

3. The method of claim 1, wherein the step of extracting comprises mixing 30 grams of dried powdered Elsholtzia ciliata herbal material with 500 mL of purified water to form a mixture, and subjecting the mixture to hydrodistillation.

4. The method of claim 3, wherein the hydrodistillation is performed at a temperature of 120±2° C. for a duration of 3 hours.

Description

DETAILED DESCRIPTION OF THE EMBODIMENTS

(1) It has been found that a previously unknown special extract can be produced by the method described, which actually has significant cardiac effects and is suitable for suppressing cardiac arrhythmias and for improving coronary perfusion. This is described in more detail below.

(2) A yellow, colored essential oil with a specific odor was produced from the dried aroma aniseed grass raw material—Elsholtzia cilliata (Thunb.) Hylander belonging to the family of Lamiaceae by hydrodistillation. For this purpose was used the Clevenger type hydrodistillation apparatus. Thirty grams of dried powdered E. ciliata herbal material was mixed with 500 mL purified water and submitted to hydrodistillation (temperature 120±2° C.). Duration of hydrodistillation is 3 hours.

(3) After chemical analysis of essential oil, using the gas chromatography-mass spectrometry method, the main chemical compounds, namely elsholtzia monoterpenes and dehydroelsholtzia ketones, which comprise respectively 14.58% and 78.28% by weight based on total weight of essential oil composition, and sesquiterpenes (4.99%), of which are determined beta-bourbonenes, beta-cubes, isocariophilins, lindens, germakren D, trans-alpha-bergamotine, alpha-farnesen, gamma-cadinin, delta-cadinin.

(4) Oral Solution—Emulsion

(5) An emulsion which consists of flavoring anion essential oil, Tween® 20 emulsifier and distilled water was produced.

(6) The aromatic aniseed grass essential oil of 40 mL is mixed with emulsion Tween® 20 of 40 mL, All components are fine mixed up. Then purified water of 20 mL is added. The resulting liquid is thoroughly mixed until a homogeneous, volatile solution (emulsion) is obtained.

(7) The mixture was stirred for about 2-3 min using magnetic stirrer.