TRACE ELEMENT SOLUTION
20230114516 · 2023-04-13
Inventors
Cpc classification
A61K33/04
HUMAN NECESSITIES
A61K33/04
HUMAN NECESSITIES
A61K9/0019
HUMAN NECESSITIES
A61K2300/00
HUMAN NECESSITIES
A61K2300/00
HUMAN NECESSITIES
International classification
A61K33/04
HUMAN NECESSITIES
A61K47/18
HUMAN NECESSITIES
A61K9/00
HUMAN NECESSITIES
Abstract
A trace element solution comprises at least the following metals zinc directly and/or indirectly from Zn-EDTA and/or Zn oxide; manganese directly and/or indirectly from Mn-EDTA and/or manganese carbonate; copper directly and/or indirectly from Cu-EDTA and/or copper oxide and/or copper sulphate, and/or copper carbonate; selenium derived directly and/or indirectly from Na.sub.2SeO.sub.4 and/or Na.sub.2SeO.sub.3. The metals are present in a solution of water, chlorocresol and/or benzyl alcohol, at a concentration of metals of at least 95 mg/ml. The pH of the trace element solution adjusted by means of 30% NaOH in an injectable trace element solution that is visually stable.
Claims
1. A trace element solution, which comprises at least the following metals: (a) zinc directly and/or indirectly from Zn-EDTA and/or Zn oxide, wherein zinc is present in at least 65 mg/ml zinc directly and/or indirectly from Zn-EDTA and/or Zn oxide; (b) manganese directly and/or indirectly from Mn-EDTA and/or manganese carbonate; (c) copper directly and/or indirectly from Cu-EDTA and/or copper oxide and/or copper sulphate, and/or copper carbonate; and to (d) selenium derived directly and/or indirectly from Na.sub.2SeO.sub.4 and/or Na.sub.2SeO.sub.3, wherein the metals are present in a solution of water, chlorocresol and/or benzyl alcohol, at a concentration of metals of at least 95 mg/ml, and wherein a ratio of zinc to manganese is at least 6.5:1.
2. The trace element solution of claim 1, wherein manganese is present in at least 10 mg/ml manganese directly and/or indirectly from Mn-EDTA and/or manganese carbonate.
3. The trace element solution of claim 1, wherein copper is present in at least 15 mg/ml copper directly and/or indirectly from Cu-EDTA and/or copper oxide and/or copper sulphate, and/or copper carbonate.
4. The trace element solution of claim 1, wherein selenium is present in at least 5 mg/ml selenium derived directly and/or indirectly from Na.sub.2SeO.sub.4 and/or Na.sub.2SeO.sub.3.
5. The trace element solution of claim 1, wherein a ratio of zinc to copper is at least 4:1.
6. The trace element solution of claim 1, wherein a ratio of zinc to selenium is at least 13:1.
7. The trace element solution of claim 1, further comprising iodine.
8. The trace element solution of claim 7, wherein iodine is present in 50 mg/ml.
9. The trace element solution of claim 7, wherein the iodine is derived from to potassium iodide.
10. The trace element solution of claim 1, wherein the pH of the trace element solution is adjusted.
11. The trace element solution of claim 10, wherein the pH is adjusted by means of 30% NaOH.
12. The trace element solution of claim 10, wherein the pH is adjusted in an injectable trace element solution that is visually stable.
Description
DESCRIPTION OF EXAMPLE
[0036] The invention will now be described by way of an example of a trace element solution in accordance with the invention.
[0037] The example relates to a trace element solution predominantly to be used for cattle and includes the mineral elements zinc, manganese, selenium and copper.
[0038] According to the invention, a trace element solution, comprises the following metals: [0039] (a) zinc directly and/or indirectly from mineral EDTA chelate(s); [0040] (b) manganese directly and/or indirectly from mineral EDTA chelate(s); [0041] (c) copper directly and/or indirectly from mineral EDTA chelate(s); and [0042] (d) selenium.
[0043] The trace element solution, comprises at least the following metals: [0044] (a) at least 65 mg/ml zinc derived directly and/or indirectly from ZN-EDTA and/or zinc oxide; [0045] (b) at least 10 mg/ml manganese derived directly and/or indirectly from Mn-EDTA and/or Mn carbonate; [0046] (c) at least 15 mg/ml copper derived directly and/or indirectly from Cu-EDTA and/or copper oxide and/or copper sulphate and/or copper carbonate; and [0047] (d) at least 5 mg/ml selenium derived from Na.sub.2SeO.sub.4 and/or Na.sub.2SeO.sub.3.
[0048] The trace element solution can additional comprise 50 mg/ml iodine.
[0049] The iodine is derived from potassium iodide.
[0050] The ratio of zinc to manganese is at least 6.5:1.
[0051] The ratio of zinc to copper is at least 4:1.
[0052] The ratio of zinc to selenium is at least 13:1.
[0053] The concentration of the metals (excluding iodine) is at least 95 mg/ml.
[0054] In addition to the aforementioned materials, the trace element solution is also be prepared with the addition of water, chlorocresol and/or benzyl alcohol.
[0055] The pH of the trace element solution is adjusted by means of 30% NaOH.
[0056] The solution can be an injectable trace element solution.
[0057] The solution is visually stable.
[0058] The mineral EDTA chelates can be derived directly and/or indirectly from Zinc oxide, manganese carbonate, copper carbonate, copper oxide, copper sulphate, EDTA and/or sodium hydroxide.
[0059] The invention also extends to a method of preparing a trace element solution as described herein.
Example 1
[0060] Specifications
TABLE-US-00001 g/L Zinc 65 Manganese 10 Copper 15 Selenium 5 Iodine 50
[0061] (A)
TABLE-US-00002 g/L 1. Purified water 637.255 2. Mn-EDTA (14.12%) 70.83 3. Zn-EDTA (16.36%) 397.31 4. Cu-EDTA (15.98%) 93.89 5. Mix with silverson until solution is clear
[0062] (B)
TABLE-US-00003 g/L 1. pH: Record pH 2. heat to 50° C. Add chlorocresol and mix 1.1 until dissolved (±10 mins) 3. pH: Record pH OR 1. pH: record pH 2. Add benzyl alcohol and mix until 10.46 dissolved (±10 mins) 3. pH: Record pH 4. Cool to <25° C. and add Na.sub.2SeO.sub.4 or 11.96/10.95 Na.sub.2SeO.sub.3 5. pH: 6. Potassium Iodide 65.407
[0063] (C)
[0064] 1. Adjust pH to 7/7.5/8 with 30% NaOH
[0065] 2. SG: 1.275-1.35
[0066] 3. Filter solution
Example 2
[0067] Specifications
TABLE-US-00004 g/L Zinc 65 Manganese 10 Copper 15 Selenium 5
[0068] (A)
TABLE-US-00005 g/L 6. Purified water 637.255 7. Mn-EDTA (14.12%) 70.83 8. Zn-EDTA (16.36%) 397.31 9. Cu-EDTA (15.98%) 93.89 10. Mix with silverson until solution is clear
[0069] (B)
TABLE-US-00006 g/L 4. pH: record 5. Heat to 50° C. add chlorocresol and 1.1 mix until dissolved (±10 mins) 6. pH: Record OR 7. pH: 8. Add benzyl alcohol and mix until dissolved (±10 mins) 10.46 9. pH: 10. Cool to <25° C.and add Na.sub.2SeO.sub.4 or 11.96/10.95 Na.sub.2SeO.sub.3 11. pH:
[0070] (C)
[0071] 1. Adjust pH to 7/7.5/8 with 30% NaOH
[0072] 2. SG: 1.275-1.35
[0073] 3. Filter solution
Example 3
[0074] Specifications
TABLE-US-00007 g/L Zinc 70 Manganese 10 Copper 15 Selenium 5 Iodine 50
[0075] (A)
TABLE-US-00008 g/L 11. Purified water 637.255 12. Mn-EDTA (14.12%) 70.83 13. Zn-EDTA (16.36%) 427.87 14. Cu-EDTA (15.98%) 93.89 15. Mix with silverson until solution is clear
[0076] (B)
TABLE-US-00009 g/L 7. pH: Record pH 8. Heat to 50° C. and Add chlorocresol and 1.1 mix until dissolved (±10 mins) 9. pH: Record pH OR 12. pH: 13. Add benzyl alcohol and mix until 10.46 dissolved (±10 mins) 14. pH: 15. Cool to <20° C. and add Na.sub.2SeO.sub.4 or 11.96/10.95 Na.sub.2SeO.sub.3 16. pH: 17. Potassium Iodide 65.407
[0077] (C)
[0078] 1. Adjust pH to 7/7.5/8 with 30% NaOH
[0079] 2. SG: 1.275-1.35
[0080] 3. Filter solution
Example 4
[0081]
TABLE-US-00010 g/L Zinc 70 Manganese 10 Copper 15 Selenium 5
[0082] (A)
TABLE-US-00011 g/L 16. Purified water 637.255 17. Mn-EDTA (14.12%) 70.83 18. Zn-EDTA (16.36%) 427.87 19. Cu-EDTA (15.98%) 93.89 20. Mix with silverson until solution is clear
[0083] (B)
TABLE-US-00012 g/L 10. pH: Record pH 11. Heat to 50° C. and Add chlorocresol and 1.1 mix until dissolved (±10 mins) 12. pH Record pH OR 18. pH: 19. Add benzyl alcohol and mix until dissolved (±10 mins) 10.46 20. pH: 21. Cool to <20° C. and add Na.sub.2SeO.sub.4 or 11.96/10.95 Na.sub.2SeO.sub.3 22. pH:
[0084] (C)
[0085] 1. Adjust pH to 7/7.5/8 with 30% NaOH
[0086] 2. SG: 1.275-1.35
[0087] 3. Filter solution