YEAST WITH ENHANCED ASTAXANTHIN
20250297208 ยท 2025-09-25
Inventors
Cpc classification
A23L33/105
HUMAN NECESSITIES
A23K20/179
HUMAN NECESSITIES
C12P23/00
CHEMISTRY; METALLURGY
A23K50/80
HUMAN NECESSITIES
C12C1/18
CHEMISTRY; METALLURGY
International classification
Abstract
An isolated nucleic acid associated with increased accumulation of astaxanthin derived from a Xanthophyllomyces dendrorhous strain. The isolated nucleic acid comprising nucleotide sequence set forth in SEQ ID NOs: 1240-12684 or a nucleotide sequence at least 80% identical thereto, or a fragment of the isolated nucleic acid, is provided, wherein the nucleotide sequence of the isolated nucleic acid is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs: 12685-19331. Associated proteins, genetic construct, cells, and methods are also provided.
Claims
1. An isolated nucleic acid comprising a variant of a nucleotide sequence set forth in: SEQ ID NO: 14894 (corresponding to CDS accession CDZ98521 of X. dendrorhous CBS 6938); SEQ ID NO: 16402 (corresponding to CDS accession CED83134 of X. dendrorhous CBS 6938); SEQ ID NO: 13437 (corresponding to CDS accession CED80058 of X. dendrorhous CBS 6938); SEQ ID NO: 13605 (corresponding to CDS accession CED80056 of X. dendrorhous CBS 6938); SEQ ID NO: 15263 (corresponding to CDS accession CDZ96150 of X. dendrorhous CBS 6938); SEQ ID NO: 15929 (corresponding to CDS accession CDZ96151 of X. dendrorhous CBS 6938); SEQ ID NO: 17082 (corresponding to CDS accession CDZ96152 of X. dendrorhous CBS 6938); SEQ ID NO: 12953 (corresponding to CDS accession CDZ96153 of X. dendrorhous CBS 6938); SEQ ID NO: 13445 (corresponding to CDS accession CED80060 of X. dendrorhous CBS 6938); SEQ ID NO: 13989 (corresponding to CDS accession CED80061 of X. dendrorhous CBS 6938); SEQ ID NO: 17215 (corresponding to CDS accession CED83656 of X. dendrorhous CBS 6938); SEQ ID NO:17373 (corresponding to CDS accession CED83814 of X. dendrorhous CBS 6938); SEQ ID NO: 18649 (corresponding to CDS accession CDZ96789 of X. dendrorhous CBS 6938); SEQ ID NO: 19046 (corresponding to CDS accession CDZ97186 of X. dendrorhous CBS 6938); SEQ ID NO: 13853 (corresponding to CDS accession CDZ98193 of X. dendrorhous CBS 6938); SEQ ID NO: 14841 (corresponding to CDS accession CDZ98468 of X. dendrorhous CBS 6938); SEQ ID NO: 15265 (corresponding to CDS accession CDZ96332 of X. dendrorhous CBS 6938); SEQ ID NO: 17534 (corresponding to CDS accession CED83975 of X. dendrorhous CBS 6938); SEQ ID NO: 15177 (corresponding to CDS accession CDZ98804 of X. dendrorhous CBS 6938); SEQ ID NO: 13440 (corresponding to CDS accession CDZ96154 of X. dendrorhous CBS 6938); or SEQ ID NO:15928 (corresponding to CDS accession CDZ96333 of X. dendrorhous CBS 6938), wherein the variant is at least 80% identical to the nucleotide sequence, or a fragment of the isolated nucleic acid.
2-23. (canceled)
24. An isolated protein encoded by the isolated nucleic acid of claim 1, or a fragment or derivative thereof.
25. The isolated protein of claim 24, wherein the protein is of a protein classification selected from ferredoxin/adrenodoxin reductase; cytochrome; ATP synthase; NADH dehydrogenase; fatty acid desaturase; Acyl-CoA-oxidase; pantothenate kinase; polyphosphate multikinase; G protein-coupled receptor; and succinate dehydrogenase.
26. The isolated protein of claim 24, wherein the protein is selected from ferredoxin/adrenodoxin reductase; mitochondrial cytochrome b2; cytochrome b; cytochrome c oxidase subunit 1; ATP synthase subunit 6; NADH dehydrogenase subunit 4; cytochrome c oxidase subunit 2; cytochrome c oxidase subunit 3; NADH dehydrogenase subunit 2; NADH dehydrogenase subunit 5; NADH dehydrogenase subunit 6; cytochrome c oxidase subunit 3; delta 9 fatty acid desaturase; Acyl-CoA-oxidase; pantothenate kinase PanK; geranylgeranyl pyrophosphate synthase; fumarate reductase; sucrose transporter; inositol polyphosphate multikinase, ARGR transcription regulatory complex component; G protein-coupled receptor, rhodopsin-like; succinate dehydrogenase; and ATP synthase subunit mitochondrial.
27. A method of modifying a nucleic acid including a step of changing one or more nucleotides of the nucleic acid to produce the isolated nucleic acid of any one of claim 1.
28. (canceled)
29. A genetic vector or construct comprising the isolated nucleic acid of any one of claim 1.
30. (canceled)
31. The vector or construct of claim 29, wherein the vector or construct is adapted for protein expression in yeast.
32. (canceled)
33. The vector or construct of claim 29, wherein the vector or construct is adapted for gene silencing in yeast.
34. (canceled)
35. The vector or construct of claim 29, wherein the vector or construct is adapted for genome editing in yeast.
36. An isolated cell comprising the nucleic acid of claim 1.
37-42. (canceled)
43. The isolated cell of claim 36, wherein the cell is a yeast cell.
44. The isolated cell of claim 43, wherein the cell is a Xanthophyllomyces cell or a Xanthophyllomyces dendrorhous cell.
45. An isolated yeast strain comprising the cell claim 43.
46-47. (canceled)
48. A method of producing astaxanthin including a step of expressing the isolated nucleic acid of claim 1 in vitro or in vivo, to thereby produce the astaxanthin.
49. A method of producing astaxanthin including a step of performing metabolism with the isolated cell of claim 36, to thereby produce the astaxanthin.
50. The method of claim 49, wherein the step of performing metabolism is or includes a step of performing fermentation with the isolated cell.
51. The method of claim 50, including a step of combining the cell or organism with a nitrogen source metabolite, such as malt extract.
52. (canceled)
53. The method of claim 50, including a step of combining the cell with a carbon source metabolite, such as molasses.
54-62. (canceled)
63. The isolated nucleic acid of claim 1, wherein the variant nucleotide sequence affects amino acid sequence or expression of an encoded protein or protein fragment.
64. An isolated cell, wherein the isolated cell has been mutagenised or genetically modified to alter expression of a protein encoded by: SEQ ID NO: 14894 (corresponding to CDS accession CDZ98521 of X. dendrorhous CBS 6938); SEQ ID NO: 16402 (corresponding to CDS accession CED83134 of X. dendrorhous CBS 6938); SEQ ID NO: 13437 (corresponding to CDS accession CED80058 of X. dendrorhous CBS 6938); SEQ ID NO: 13605 (corresponding to CDS accession CED80056 of X. dendrorhous CBS 6938); SEQ ID NO: 15263 (corresponding to CDS accession CDZ96150 of X. dendrorhous CBS 6938); SEQ ID NO: 15929 (corresponding to CDS accession CDZ96151 of X. dendrorhous CBS 6938); SEQ ID NO: 17082 (corresponding to CDS accession CDZ96152 of X. dendrorhous CBS 6938); SEQ ID NO: 12953 (corresponding to CDS accession CDZ96153 of X. dendrorhous CBS 6938); SEQ ID NO: 13445 (corresponding to CDS accession CED80060 of X. dendrorhous CBS 6938); SEQ ID NO: 13989 (corresponding to CDS accession CED80061 of X. dendrorhous CBS 6938); SEQ ID NO: 17215 (corresponding to CDS accession CED83656 of X. dendrorhous CBS 6938); SEQ ID NO:17373 (corresponding to CDS accession CED83814 of X. dendrorhous CBS 6938); SEQ ID NO: 18649 (corresponding to CDS accession CDZ96789 of X. dendrorhous CBS 6938); SEQ ID NO: 19046 (corresponding to CDS accession CDZ97186 of X. dendrorhous CBS 6938); SEQ ID NO: 13853 (corresponding to CDS accession CDZ98193 of X. dendrorhous CBS 6938); SEQ ID NO: 14841 (corresponding to CDS accession CDZ98468 of X. dendrorhous CBS 6938); SEQ ID NO: 15265 (corresponding to CDS accession CDZ96332 of X. dendrorhous CBS 6938); SEQ ID NO: 17534 (corresponding to CDS accession CED83975 of X. dendrorhous CBS 6938); SEQ ID NO: 15177 (corresponding to CDS accession CDZ98804 of X. dendrorhous CBS 6938); SEQ ID NO: 13440 (corresponding to CDS accession CDZ96154 of X. dendrorhous CBS 6938); or SEQ ID NO:15928 (corresponding to CDS accession CDZ96333 of X. dendrorhous CBS 6938), or to alter expression of a protein fragment or derivative of the protein.
Description
BRIEF DESCRIPTION OF THE FIGURES
[0077] In order that the invention may be readily understood and put into practical effect, typical embodiments will now be described by way of example with reference to the accompanying figures, wherein:
[0078]
[0079]
[0080]
[0081]
[0082]
[0083]
[0084]
[0085]
[0086]
[0087]
[0088]
[0089]
[0090]
[0091]
[0092]
[0093]
[0094]
[0095]
BRIEF DESCRIPTION OF THE SEQUENCE LISTING
[0096] SEQ ID NOs:1-1239: Genomic sequence contigs from re-sequencing of a sample of X. dendrorhous CBS 6938.
[0097] SEQ ID NOs:1240-2795: Genomic sequence contigs of mutant X. dendrorhous strain MAMY3.
[0098] SEQ ID NOs:2796-4360: Genomic sequence contigs of mutant X. dendrorhous strain MAMY6.
[0099] SEQ ID NOs:4361-5500: Genomic sequence contigs of mutant X. dendrorhous strain MB18.
[0100] SEQ ID NOs:5501-6921: Genomic sequence contigs of mutant X. dendrorhous strain MB24.
[0101] SEQ ID NOs:6922-8057: Genomic sequence contigs of mutant X. dendrorhous strain MYM0.
[0102] SEQ ID NOs:8058-9311: Genomic sequence contigs of mutant X. dendrorhous strain MYM6.
[0103] SEQ ID NOs:9312-11033: Genomic sequence contigs of mutant X. dendrorhous strain MYM44.
[0104] SEQ ID NOs:11034-12684: Genomic sequence contigs of mutant X. dendrorhous strain MYM92.
[0105] SEQ ID NOs:12685-12950: Genomic sequence scaffolds of X. dendrorhous CBS 6938 (ATCC 96594) as published by Sharma et al. BMC genomics 16.1 (2015): 1-13 and publicly available via fungi.ensembl.org/info/data/ftp/index.html.
[0106] SEQ ID NOs:12951-19331: CDS sequences of X. dendrorhous CBS 6938 (ATCC 96594) as published by Sharma et al. BMC genomics 16.1 (2015): 1-13 and publicly available via fungi.ensembl.org/info/data/ftp/index.html.
Biological Deposits
[0107] The following biological deposits are incorporated herein under the provisions of the Budapest Treaty. To avoid doubt, this incorporation is not, and is not to be interpreted as, a suggestion that the incorporated deposits are required to work the invention.
[0108] CBS 145279: Phaffia rhodozyma BPAX-A1 (alternatively referred to herein as Xanthophyllomyces dendrorhous MYM0) deposited with Westerdijk Fungalbio Diversity Institute, an International Depository Authority at Uppsalalaan 8, 3584 CT Utrecht, Netherlands, on 6 Dec. 2018.
[0109] CBS 145280: Phaffia rhodozyma BPAX-A2 (alternatively referred to herein as Xanthophyllomyces dendrorhous MYM92) deposited with Westerdijk Fungalbio Diversity Institute, an International Depository Authority at Uppsalalaan 8, 3584 CT Utrecht, Netherlands, on 6 Dec. 2018.
DETAILED DESCRIPTION
[0110] This invention is at least partly predicated on the identification of mutations in yeast associated with increased accumulation of astaxanthin.
[0111] One aspect of the invention is directed to isolated nucleic acids. In typical embodiments, the isolated nucleic acids are associated with increased accumulation of astaxanthin, as herein described.
[0112] For the purposes of this invention, by isolated is meant material that has been removed from its natural state or otherwise been subjected to human manipulation. Isolated material may be substantially or essentially free from components that normally accompany it in its natural state, or may be manipulated so as to be in an artificial state together with components that normally accompany it in its natural state. Isolated material may be in native, chemical synthetic or recombinant form.
[0113] The term nucleic acid as used herein designates single or double-stranded DNA and RNA. DNA includes genomic DNA and cDNA. RNA includes mRNA, RNA, RNAi, siRNA, cRNA and autocatalytic RNA. Nucleic acids may also be DNA-RNA hybrids. A nucleic acid comprises a nucleotide sequence which typically includes nucleotides that comprise an A, G, C, T or U base. However, nucleotide sequences may include other bases such as inosine, methylycytosine, methylinosine, methyladenosine and/or thiouridine, although without limitation thereto.
[0114] A polynucleotide is a nucleic acid having eighty (80) or more contiguous nucleotides, while an oligonucleotide has less than eighty (80) contiguous nucleotides.
[0115] A probe may be a single or double-stranded oligonucleotide or polynucleotide, suitably labelled for the purpose of detecting complementary sequences in northern or Southern blotting, for example.
[0116] A primer is usually a single-stranded oligonucleotide, typically having 15-50 contiguous nucleotides, which is capable of annealing to a complementary nucleic acid template and being extended in a template-dependent fashion by the action of a DNA polymerase such as Taq polymerase, RNA-dependent DNA polymerase or Sequenase.
[0117] A typical embodiment of this aspect provides an isolated nucleic acid comprising a nucleotide sequence set forth in SEQ ID NOs:1240-12684 or a nucleotide sequence at least 80% identical thereto, or a fragment of the isolated nucleic acid.
[0118] Reference is made herein to sequence identity, in the context of comparisons of nucleotide and/or amino acid sequences. Terms used generally herein to describe sequence relationships between respective sequences of nucleic acids and proteins may include comparison window, sequence identity, percentage of sequence identity and substantial identity, and the like.
[0119] Because respective nucleic acids/proteins or sequences thereof may each comprise (1) only one or more portions that are shared, and (2) one or more portions which are divergent between the nucleic acids/proteins, sequence comparisons are typically performed by comparing sequences over a comparison window to identify and compare local regions of sequence similarity. A comparison window refers to a conceptual segment of typically 6, 9 or 12 contiguous residues that is compared to a reference sequence. The comparison window may comprise additions or deletions (i.e., gaps) of about 20% or less as compared to the reference sequence for optimal alignment of the respective sequences.
[0120] Optimal alignment of sequences for aligning a comparison window may be conducted by computerised implementations of algorithms (Geneworks program by Intelligenetics; GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package Release 7.0, Genetics Computer Group, 575 Science Drive Madison, WI, USA) or by inspection, and the best alignment (i.e., resulting in the highest percentage homology over the comparison window) generated by any of the various methods selected. Reference also may be made to the BLAST family of programs as for example disclosed by Altschul et al, 1997, Nucl. Acids Res. 25 3389. A detailed discussion of sequence analysis can be found in Unit 19.3 of CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds. Ausubel et al. (John Wiley & Sons Inc NY, 1995-1999). Other assessment of sequence alignment approaches can be found, for example, in Thompson et al, 2011, PLOS ONE. 6 (3): e18093, and Nuin et al, 2006, BMC Bioinformatics. 7: 471.
[0121] The term sequence identity is used herein in its broadest sense to include the number of exact nucleotide or amino acid matches having regard to an appropriate alignment using a standard algorithm, having regard to the extent that sequences are identical over a window of comparison. Thus, a percentage of sequence identity is calculated by comparing two optimally aligned sequences over the window of comparison, determining the number of positions at which the identical nucleic acid base (e.g., A, T, C, G, U) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of sequence identity. For example, sequence identity may be understood to mean the match percentage calculated by the DNASIS computer program, Version 2.5 for Windows, as was made available from Hitachi Software engineering Co., Ltd., South San Francisco, California, USA.
[0122] Typically, the isolated nucleic acid according to this aspect comprises a nucleotide sequence at least about 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a nucleotide sequence set forth in SEQ ID NOs:1240-12684.
[0123] As set out hereinabove, this aspect is also directed to fragments of the isolated nucleic acid. More generally, reference is made herein to fragments of nucleic acids and proteins. It will be understood that, as used herein, a nucleic acid or protein fragment includes a nucleotide sequence or amino acid sequence, respectively, of less than 100% of that of the full nucleic acid or protein, respectively.
[0124] The nucleic acid or protein fragment may comprise about, or at least about, 10, 20, 50, 100, 150, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1500, 2000, 5000, or 10000 contiguous nucleotides or amino acids of the nucleic acid or protein, respectively. In embodiments, the nucleic acid or protein fragment comprises about, or at least about, 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90-99% of the full length of the nucleic acid or protein, respectively.
[0125] Suitably, the nucleotide sequence of the isolated nucleic acid of this aspect is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950.
[0126] The skilled person will appreciate that SEQ ID NOs:12685-12950 correspond to the published genome sequence of the sequenced wild-type yeast strain Xanthophyllomyces dendrorhous CBS 6938 as reported in Sharma et al. BMC genomics 16.1 (2015): 1-13.
[0127] Suitably, the nucleotide sequence of the isolated nucleic acid of this aspect is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12951-19331.
[0128] The skilled person will appreciate that SEQ ID NOs:12951-19331 correspond to the published CDS annotations of the sequenced wild-type yeast strain Xanthophyllomyces dendrorhous CBS 6938 as reported in Sharma et al. BMC genomics 16.1 (2015): 1-13.
[0129] Typically, the nucleotide sequence of the isolated nucleic acid according to this aspect is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0130] As set out in Example 1, SEQ ID NOs:1-1239 correspond to the re-sequenced genome of wild-type Xanthophyllomyces dendrorhous CBS 6938.
[0131] The skilled person will appreciate that various annotations for Xanthophyllomyces dendrorhous CBS 6938 are publicly available as at the filing date, including those annotations hosted at fungi.ensembl.org/info/data/ftp/index.html. To avoid doubt, all such publicly available annotation data is incorporated herein in full, by reference.
[0132] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a nucleotide sequence set forth in SEQ ID NOs: 12685-19331.
[0133] As used herein, a nucleotide or amino acid sequence variant will be understood to have one or more nucleotides or amino acids changes, respectively, inclusive of substitutions and deletions. Said changes may be referred to as variations of the nucleotide or amino acid sequence.
[0134] Typically, variants of a nucleotide sequence or amino acid sequence share at least about 70% or 75%, more typically at least about 80% or 85%, and even more typically at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with the nucleotide sequence or amino acid sequence.
[0135] In some embodiments, a nucleic acid comprising a variant of a nucleotide sequence will hybridize to isolated nucleic acids comprising the nucleotide sequence, under at least low stringency conditions, typically under at least medium stringency conditions, more typically under high stringency conditions.
[0136] Hybridize and hybridization is used herein to denote the pairing of at least partly complementary nucleotide sequences to produce a DNA-DNA, RNA-RNA or DNA-RNA hybrid. Hybrid sequences comprising complementary nucleotide sequences occur through base-pairing between complementary purines and pyrimidines as is well known in the art. In this regard, it will be appreciated that modified purines (for example, inosine, methylinosine and methyladenosine) and modified pyrimidines (thiouridine and methylcytosine) may also engage in base pairing.
[0137] Stringency as used herein, refers to temperature and ionic strength conditions, and presence or absence of certain organic solvents and/or detergents during hybridisation. The higher the stringency, the higher will be the required level of complementarity between hybridizing nucleotide sequences.
[0138] In general terms, high stringency conditions designate those conditions under which only nucleic acid having a high frequency of complementary bases will hybridize.
[0139] Reference herein to high stringency conditions includes and encompasses: [0140] (i) from at least about 31% v/v to at least about 50% v/v formamide and from at least about 0.01 M to at least about 0.15 M salt for hybridisation at 42 C., and at least about 0.01 M to at least about 0.15 M salt for washing at 42 C.; [0141] (ii) 1% BSA, 1 mM EDTA, 0.5 M NaHP0 4 (pH 7.2), 7% SDS for hybridization at 65 C., and (a) 0.1SSC, 0.1% SDS; or (b) 0.5% BSA, 1 mM EDTA, 40 mM NaHPO.sub.4 (pH 7.2), 1% SDS for washing at a temperature in excess of 65 C. for about one hour; and [0142] (iii) 0.2SSC, 0.1% SDS for washing at or above 68 C. for about 20 minutes.
[0143] In general, washing is carried out at T.sub.m=69.3+0.41 (G+C) %12 C. In general, the T.sub.m of a duplex DNA decreases by about 1 C. with every increase of 1% in the number of mismatched bases.
[0144] Notwithstanding the above, stringent conditions are well known in the art, such as described in Chapters 2.9 and 2.10 of Ausubel et al, supra. The skilled person will also recognize that various factors can be manipulated to optimize the specificity of the hybridization. Optimization of the stringency of the final washes can serve to ensure a high degree of hybridization.
[0145] It will be appreciated by the skilled person that isolated nucleic acids comprising a variant nucleotide sequence may be producing using a nucleic acid amplification technique. Suitable nucleic acid amplification techniques are well known to the skilled person and include polymerase chain reaction (PCR), strand displacement amplification (SDA), rolling circle replication (RCR), nucleic acid sequence-based amplification (NASBA), Q- replicase amplification, and helicase-dependent amplification, although without limitation thereto.
[0146] As used herein, an amplification product refers to a nucleic acid product generated by nucleic acid amplification.
[0147] Particularly for analytical purposes, nucleic acid amplification techniques may include quantitative and semi-quantitative techniques such as qPCR, real-time PCR and competitive PCR, as are well known in the art.
[0148] Suitably, isolated nucleic acids comprising a variant of a nucleotide sequence may be produced using nucleic acid amplification techniques using one or more degenerate primers based on, or derived from, an isolated nucleic acid comprising the nucleotide sequence.
[0149] It is well understood in the art that some nucleotide changes do not change an encoded amino acid sequence (synonymous changes), while some nucleotide sequences change an encoded amino acid sequence (non-synonymous changes). In some typical embodiments, the nucleotide sequence of the isolated nucleic acid is a variant of a nucleotide sequence set forth in SEQ ID NOs: 12685-19331 comprising a non-synonymous nucleotide change.
[0150] It is well understood in the art that some amino acid changes do not substantially change affect activity (conservative changes), while some amino acid changes substantially affect protein activity (non-conservative changes). In some typical embodiments, the nucleotide sequence of the isolated nucleic acid is a variant of a nucleotide sequence set forth in SEQ ID NOs: 12685-19331 encoding a non-conservative amino acid change.
[0151] It will be further understood that nucleotide and/or amino acid variations may be more specifically characterised in a range of ways as will be known to the skilled person. For the purposes of this invention, nucleotide changes may (by way of non-limiting example) be characterised with reference to a gene or CDS region as: synonymous (resulting in no change to an encoded amino acid sequence); missense (resulting in a change to an encoded amino acid sequence); upstream (occurring upstream of the gene or CDS); upstream less than or equal to 100 base pairs (occurring within 100 base pairs of the start of the gene or CDS), downstream (occurring downstream of the gene or CDS), downstream less than or equal to 100 bp (occurring within 100 base pairs of the end of the gene or CDS); intergenic (occurring in a region between respective genes or CDSs); intron variant (occurring in an intron of the gene or unspliced sequence containing the CDS); splice variant (causing a variation in splicing of the gene or unspliced sequence containing the CDS); stop gained (introducing a stop codon into the gene or CDS); start lost (removing a start codon from the gene or CDS).
[0152] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid is a variant of a nucleotide sequence set forth in SEQ ID NOs: 12685-19331 characterised as synonymous, missense, upstream, upstream less than or equal to 100 base pairs, downstream, downstream less than or equal to 100 bp, intergenic, intron variant, splice variant, stop gained, or start lost, with reference to one or more suitable genes or CDSs.
[0153] Tables 12, 13, 14, and 15 set out hereinbelow show nucleotide sequence variations identified relative to genomic scaffolds published by Sharma et al. BMC genomics 16.1 (2015): 1-13, which scaffolds are incorporated herein as SEQ ID NOs:12685-12950, as hereinabove described. CDS sequences as published by Sharma et al. BMC genomics 16.1 (2015): 1-13 in or near to which the nucleotide sequence variations are located (as applicable) are also shown in Tables 12-15, which CDS sequences are incorporated herein as SEQ ID NOs:12951-19331, as hereinabove described.
[0154] With reference to Sharma et al. BMC genomics 16.1 (2015): 1-13, SEQ ID NOs:12685-12950, and SEQ ID NOs:12951-19331, the skilled person will readily appreciate that each respective nucleotide sequence variation as set out in Tables 12-15 can be characterised as a variation of: [0155] a genic region, i.e. a region from the transcription start site to the end of the 3 UTR for a given gene; [0156] a regulatory region, i.e. a region associated with regulation of expression of a given gene; or [0157] an intergenic region, i.e. a region that is not a genic or regulatory region.
[0158] By way of example, as per Table 12: [0159] variation X.sub.223 is a variation of a nucleotide sequence in a genic region of CDS CED80056; [0160] variation X.sub.246 is a variation of a nucleotide sequence in a regulatory region for CDS CED80058; [0161] variation X.sub.260 is a variation of a nucleotide sequence in an intergenic region located towards the start of genomic scaffold 7 as per Sharma et al, supra.
[0162] By way of another example, as per Table 13: [0163] variation Y.sub.24 is a variation of a nucleotide sequence in a genic region of CDS CED80060; [0164] variation Y.sub.322 is a variation of a nucleotide sequence in a regulatory region for CDS CED85243.
[0165] By way of another example, as per Table 14: [0166] variation Z.sub.9 is a variation of a nucleotide sequence in a genic region of CDS CDZ96153; [0167] variation Z.sub.24 is a variation of a nucleotide sequence in a regulatory region for CDS CED83975.
[0168] By way of another example, as per Table 15: [0169] variation V.sub.3 is a variation of a nucleotide sequence in a genic region of CDS CDZ98193; [0170] variation V.sub.23 is a variation of a nucleotide sequence in a regulatory region for CDZ96151.
[0171] It will be further appreciated that variations as set forth in Tables 12-15 may be more specifically characterised, such as in the manner hereinabove described including characterisations such as synonymous, missense, upstream, downstream, intergenic, intron variant, splice variant, stop gained, or start lost. Characterisation in said (or similar) manner is provided in Tables 12-15.
[0172] With reference to Example 1 and Table 12, it will be appreciated that variations X.sub.1-X.sub.222 are variations identified in the re-sequenced wild-type Xanthophyllomyces dendrorhous strain relative to the published genome sequence in Sharma et al., supra.
[0173] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a genic, regulatory, or intergenic sequence as set out in Table 12. The nucleotide sequence variant may be associated with a change in an encoded amino acid sequence and/or expression of a CDS sequence set out in Table 12.
[0174] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a genic, regulatory, or intergenic region as set out in Table 13. The nucleotide sequence variant may be associated with a change in an encoded amino acid sequence and/or expression of a CDS sequence set out in Table 13.
[0175] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a genic, regulatory, or intergenic region as set out in Table 14. The nucleotide sequence variant may be associated with a change in an encoded amino acid sequence and/or expression of a CDS sequence set out in Table 14.
[0176] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a genic, regulatory, or intergenic region as set out in Table 15. The nucleotide sequence variant may be associated with a change in an encoded amino acid sequence and/or expression of a CDS sequence set out in Table 15.
[0177] Tables 16 and 17 set out hereinbelow show transcript expression in a mutant Xanthophyllomyces dendrorhous strain (MYM0) relative to the wild-type CBS 6938 strain. In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a nucleotide sequence encoding a transcript set out in Table 16. In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a nucleotide sequence encoding a transcript set forth in Table 17.
[0178] With reference to Sharma et al. BMC genomics 16.1 (2015): 1-13, SEQ ID NOs:12685-12950, and SEQ ID NOs:12951-19331, at least certain regulatory sequences associated with control of expression of the transcripts set out in Table 16 and Table 17 will be apparent to or readily determinable by the skilled person. The skilled person is further directed to all annotations available at fungi.ensembl.org/info/data/ftp/index.html for the wild-type CBS 6938 strain, incorporated herein by reference.
[0179] Accordingly, in some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a regulatory sequence for a transcript set out in Table 16. In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a regulatory sequence for a transcript set out in Table 17.
[0180] Tables 18 and 19 set out hereinbelow show CDS sequences encoding proteins differentially expressed (based on proteomic analysis) in Xanthophyllomyces dendrorhous strain MYM0 relative to the wild-type CBS 6938 strain. In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a variant of a CDS sequence set out in Table 18 and/or Table 19. The nucleotide sequence variant may be associated with a change in an encoded amino acid sequence and/or expression of a CDS sequence set out in Table 18 and/or Table 19.
[0181] With reference to Sharma et al. BMC genomics 16.1 (2015): 1-13, SEQ ID NOs:12685-12950, and SEQ ID NOs:12951-19331, at least certain regulatory sequences associated with control of expression of CDS sequences and encoded proteins set out in Table 18 and Table 19 will be apparent to or readily determinable by the skilled person. The skilled person is further directed to all annotations available at fungi.ensembl.org/info/data/ftp/index.html for the wild-type CBS 6938 strain, incorporated herein by reference.
[0182] Accordingly, in some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect is a regulatory sequence for a CDS sequence and/or encoded protein set out in Table 18 and/or Table 19.
[0183] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid of this aspect comprises a nucleotide change at a position of one or more variations X.sub.223-X.sub.8395, as set forth in Table 12, relative to SEQ ID NOs:12685-12950. Typically, the nucleotide change comprises a change at a different position than any of the variations X.sub.1-X.sub.222, as set forth in Table 12, relative to SEQ ID NOs:12685-12950.
[0184] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid comprises a nucleotide change of one or more variations X.sub.223-X.sub.8395, as set forth in Table 12, relative to SEQ ID NOs:12685-12950. Typically, the nucleotide change comprises a change that is different than any of the variations X.sub.1-X.sub.222, as set forth in Table 12, relative to SEQ ID NOs:12685-12950.
[0185] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid comprises a nucleotide change at a position of one or more variations Y.sub.1-Y.sub.368, as set forth in Table 13, relative to SEQ ID NOs:12685-12950.
[0186] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid comprises a nucleotide change of one or more variations Y.sub.1-Y.sub.368, as set forth in Table 13, relative to SEQ ID NOs:12685-12950.
[0187] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid comprises a nucleotide change at a position of one or more variations Z.sub.1-Z.sub.25, as set forth in Table 14, relative to SEQ ID NOs:12685-12950.
[0188] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid comprises a nucleotide change of one or more variations Z.sub.1-Y.sub.25, as set forth in Table 14, relative to SEQ ID NOs:12685-12950.
[0189] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid comprises a nucleotide change at a position of one or more variations V.sub.1-Z.sub.26, as set forth in Table 15, relative to SEQ ID NOs:12685-12950.
[0190] In some typical embodiments, the nucleotide sequence of the isolated nucleic acid comprises a nucleotide change of one or more variations V.sub.1-V.sub.26, as set forth in Table 15, relative to SEQ ID NOs:12685-12950.
[0191] SEQ ID NOs:1240-2795 are genomic sequence contigs of mutant X. dendrorhous strain MAMY3. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:1240-2795 or a variant thereof, wherein the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0192] SEQ ID NOs:2796-4360 are genomic sequence contigs of mutant X. dendrorhous strain MAMY6. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:2796-4360 or a variant thereof, wherein the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0193] SEQ ID NOs:4361-5500 are genomic sequence contigs of mutant X. dendrorhous strain MB18. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:4361-5500 or a variant thereof, wherein the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0194] SEQ ID NOs:5501-6921 are genomic sequence contigs of mutant X. dendrorhous strain MB24. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:5501-6921 or a variant thereof, wherein the nucleotide sequence is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0195] SEQ ID NOs:6922-8057 are genomic sequence contigs of mutant X. dendrorhous strain MYM0. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:6922-8057 or a variant thereof, wherein the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0196] SEQ ID NOs:8058-9311 are genomic sequence contigs of mutant X. dendrorhous strain MYM6. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:8058-9311 or a variant thereof, wherein the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0197] SEQ ID NOs:9312-11033 are genomic sequence contigs of mutant X. dendrorhous strain MYM44. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:9312-11033 or a variant thereof, wherein the nucleotide sequence is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0198] SEQ ID NOs:11034-12684 are genomic sequence contigs of mutant X. dendrorhous strain MYM92. In some typical embodiments, the isolated nucleic acid comprises a nucleotide sequence set forth in SEQ ID NOs:11034-12684 or a variant thereof, wherein the nucleotide sequence is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:12685-12950 or SEQ ID NOs:12951-19331. Typically, the nucleotide sequence or variant thereof is not identical to any one of the nucleotide sequences set forth in SEQ ID NOs:1-1239.
[0199] Another aspect of the invention provides an isolated protein encoded by the isolated nucleic acid of the preceding aspect, or a fragment, variant, or derivative of the isolated protein.
[0200] By protein is meant an amino acid polymer. The amino acids may be natural or non-natural amino acids, D- or L-amino acids as are well understood in the art.
[0201] A peptide is a protein having no more than fifty (50) amino acids.
[0202] A polypeptide is a protein having more than fifty (50) amino acids.
[0203] As used herein, derivative proteins have been altered, for example by conjugation or complexing with other chemical moieties, by post-translational modification (e.g. phosphorylation, acetylation etc.), modification of glycosylation (e.g. adding, removing or altering glycosylation) and/or inclusion of additional amino acid sequences as is understood in the art.
[0204] Additional amino acid sequences may include fusion partner amino acid sequences which create a fusion protein. By way of example, fusion partner amino acid sequences may assist in detection and/or purification of the isolated fusion protein. Non-limiting examples include metal-binding (e.g. polyhistidine) fusion partners, maltose binding protein (MBP), Protein A, glutathione S-transferase (GST), fluorescent protein sequences (e.g. GFP), epitope tags such as Myc, FLAG and haemagglutinin tags.
[0205] For the particular purpose of fusion polypeptide purification by affinity chromatography, relevant matrices for affinity chromatography include glutathione-, amylose-, and nickel- or cobalt conjugated resins respectively. Many such matrices have been made available in kit form, such as the QIAexpress system (Qiagen) useful with (HIS6) fusion partners and the Pharmacia GST purification system.
[0206] Preferably, the fusion partners also have protease cleavage sites, such as for Factor X or Thrombin, which allow the relevant protease to partially digest the fusion polypeptide of the invention and thereby liberate the recombinant polypeptide of the invention therefrom. The liberated polypeptide can then be isolated from the fusion partner by subsequent chromatographic separation.
[0207] Other protein derivatives include, but are not limited to, modification to amino acid side chains, incorporation of unnatural amino acids and/or their derivatives during peptide, polypeptide or protein synthesis and the use of crosslinkers and other methods which impose conformational constraints on the isolated protein, fragments and variants disclosed herein.
[0208] In embodiments, the isolated protein of this aspect is of a protein classification selected from: cytochrome c oxidase subunit 1; ATP synthase subunit 6; NADH dehydrogenase; NADH dehydrogenase subunit 4; cytochrome c oxidase subunit 2; NADH dehydrogenase subunits 2, 5; cytochrome b; NADH dehydrogenase subunit 6; cytochrome c oxidase subunit 3; V-SNARE; DNA polymerase zeta; mRNA splicing factor; ubiquitin-conjugating enzyme E2-binding protein; transcription coactivator protein; phosphoenolpyruvate carboxykinase; mercaptopyruvate sulfurtransferase/thiosulfate sulfurtransferase; HLH transcription factor EBF/Olf-1; peptidase S9; capl-related protein; C4-type Zn-finger protein; endonuclease MUS81; p-loop containing nucleoside triphosphate hydrolase protein; inorganic phosphate transporter; nuclear AAA ATPase (VCP subfamily); leucine-trna ligase; xanthine uracil permease; basic-leucine zipper domain protein; DNA-binding centromere protein B (CENP-B); dimeric dihydrodiol dehydrogenase; pre-mRNA splicing factor prp1; ATP-dependent clp protease proteolytic subunit; myosin 5; MYND Zn-finger protein; splicing factor 3b, subunit 2; OCH1; phosphoinositide phosphatase; ATP synthase subunit mitochondrial kinase-like protein; small molecule transporter protein; B-block binding subunit of TFIIIC; pre-mRNA-splicing factor clf1; transcriptional regulator protein; DnaJ superfamily molecular chaperone; atypical pikk frap protein kinase; 1,4-alpha-glucan branching enzyme/starch branching enzyme II; cyclin-dependent kinase regulatory subunit; heat shock protein 60; FOG protein; density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1); CDC12-septin; MRG-domain-containing protein; mitochondrial cytochrome b2; eukaryotic translation initiation factor 2 subunit alpha; Zn-finger protein; DNA mismatch repair protein; ATPase; RNA polymerase II, subunit POLR2C/RPB3; ATP-dependent metallopeptidase HFL; sexual differentiation process protein ISP4; extracellular protein SEL-1; nucleic acid-binding, OB-fold protein; dead-domain-containing protein; 60s ribosomal protein 121; protein phosphatase; regulatory subunit PPP1R3C/D; ATP-dependent RNA helicase dhx8; RmlC-like jelly roll fold protein; white collar 1 protein; UV radiation resistance associated protein; SAP family cell cycle dependent phosphatase-associated protein; exosomal 3-5 exoribonuclease complex, subunit Rrp44/Dis3; ABC transporter; peptidase M28; delta 9 fatty acid desaturase; microtubule binding protein; DNA replication factor large subunit; beta and beta-prime subunits of DNA dependent RNA-polymerase; aspartate-semialdehyde dehydrogenase; metalloexopeptidase; acyl-oxidase; E3 ubiquitin ligase; TPR repeat-containing protein; peroxisomal half ABC transporter; nucleosome assembly protein; mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit); inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex; ATP-dependent RNA helicase DBP5; SMAD/FHA domain; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2; immunoglobulin-like; pre-mRNA splicing factor; g-protein alpha-subunit; F-box protein containing LRR; DRIM (down-regulated in metastasis)-like proteins; acid phosphatase; extracellular matrix glycoprotein Laminin subunits alpha and gamma; GTP-binding protein ypt1; DNA repair protein; mRNA (guanine-n7-)-methyltransferase; ataxia telangiectasia protein; ornithine decarboxylase antizyme; aldo/keto reductase family proteins; spermidine/spermine synthases family; membrane protein; high-affinity cell membrane calcium channel; WD40/YVTN repeat-like-containing domain; Golgi apparatus membrane protein TVP23; conserved hypothetical protein CHP02453; AAA-type ATPase; HSP20-like chaperone; pantothenate kinase PanK; mediator complex, subunit Med4; M13 family peptidase; Ca-transporting ATPase; histone tail methylase containing SET domain; ribonuclease iii; zinc finger, RING-type; 40s ribosomal protein s15; nuclear export receptor crml; voltage-gated chloride channel; phosphatidylinositol 4-kinase; geranylgeranyl pyrophosphate synthase; membrane coat complex retromer, subunit VPS5/SNX1; iron permease FTR1; t-complex protein alpha subunit (tcp-1-alpha); short chain-type dehydrogenase; polyadenylation factor I complex, subunit, Yth1 (CPSF subunit); lipase; RNA polymerase III, subunit C34; cytoplasm protein; plant ascorbate peroxidase; lysine-tRNA ligase; retrotransposon tyl-copia subclass; GTP-binding protein; ring finger protein; cytochrome b5; tetraspanin/peripherin; snf2 family amino-terminal protein; arginyl-tRNA synthetase; dihydropteroate synthase; START-like domain protein; WD40 repeat-containing protein; alanine-tRNA ligase; protein kinase essential for the initiation of DNA replication; palp-domain-containing protein; arginase deacetylase; ATP-NAD kinase; fumarate reductase; peptidase c1b bleomycin hydrolase; cytochrome c oxidase, subunit IV/COX5b; 1-aminocyclopropane-1-carboxylate synthase, and related proteins; endosomal p24a protein; sirtuin 4 and related class II sirtuins (SIR2 family); protein-tyrosine/dual specificity phosphatase; calcineurin responsive transcription factor przl; acyl-n-acyltransferase; maintenance of telomere capping protein 1, Mtcl; beta-1,6-N-acetylglucosaminyltransferase; Zn(2)-C6 fungal-type DNA-binding domain; nuclear pore complex, Nup155 component; E3 ubiquitin protein ligase; transmembrane protein; major facilitator superfamily domain, general substrate transporter; protein kinase; glucosyltransferase-Alg8p; Golgi-associated protein/Nedd4 WW domain-binding protein; origin recognition complex, subunit 1; cysteine proteinase; related to C2H2 zinc finger protein FLBC; C-14 reductase; hydroxymethylglutaryl-CoA reductase; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4; microfibrillar-associated protein MFAP1; tetratricopeptide-like helical; SNF2-family ATP dependent chromatin remodeling factor SNF21; arsenical pump-driving atpase; guanylate kinase; fatty acid-2 hydroxylase; sucrose transporter; RNA polymerase I termination factor, MYB superfamily; ferredoxin/adrenodoxin reductase; WD40 repeat-like protein; HSP90 co-chaperone CNS1 (contains TPR repeats); RhoGEF GTPase; vacuole import and degradation protein; mitochondrial Fe2 transporter MMT 1 and related transporters (cation diffusion facilitator superfamily); glycoside hydrolase, superfamily; CLASP N-terminal domain; pinin/SDK/MemA protein; G protein-coupled receptor, rhodopsin-like; histone deacetylase clr6; methylase protein; and RAB protein geranylgeranyltransferase component A.
[0209] It will be appreciated that the preceding protein classifications correspond to proteins encoded by one or more nucleotide sequences as herein described with reference to Examples 1 and 2 and Tables 12 and 13.
[0210] In some embodiments, the isolated protein of this aspect is of a protein classification selected from: short-chain dehydrogenase; deoxyribodipyrimidine photolyase/cryptochrome; nuclear transport factor 2; 60s ribosomal protein 132; armadillo/beta-catenin-like repeat-containing protein; 60s ribosomal protein 110a; pyridoxamine 5-phosphate oxidase-like, FMN-binding domain; glutaredoxin-related protein; glycosyl transferase, family 8-glycogenin; mitochondrial carrier; nucleosome assembly protein; sterile alpha motif, type 2; snare protein ykt6; UDP-glucose dehydrogenase; predicted translation factor, contains W2 domain; G-protein beta subunit-like protein; heat shock protein HSS1; 40s ribosomal protein s7; ATP synthase f1 beta subunit; catalase 1; stress responsive alpha-beta barrel; cytokinin riboside 5-monophosphate phosphoribohydrolase LOG; EF-hand domain pair; 20s proteasome subunit; ferrochelatase; glycine hydroxymethyltransferase; carboxypeptidase s; NADH-ubiquinone oxidoreductase 304 kDa subunit precursor; phytoene dehydrogenase; ribosomal protein L49/IMG2; nop10p-domain-containing protein; thioredoxin/protein disulfide isomerase; predicted dehydrogenase; 6-phosphogluconate dehydrogenase; NADH-dehydrogenase (ubiquinone); COPII vesicle protein; ornithine aminotransferase; ER-associated protein catabolism-related protein; isocitrate dehydrogenase; AAA atpase; probable NADP-dependent dehydrogenase acting on 3-hydroxy acids; CNDP dipeptidase; actin-related protein Arp2/3 complex, subunit ARPC2; branched-chain amino acid aminotransferase ii; carbon-nitrogen hydrolase; aspartate aminotransferase; NADPH oxidase; 26s proteasome subunit p45; pre-mRNA-splicing factor rsel; porphobilinogen deaminase; prolyl oligopeptidase; ABC transporter; 40s ribosomal protein s9; polyadenylate-binding protein; ATP-dependent RNA helicase dhx8; fatty acid synthase complex subunit alpha; glycosyltransferase family 35 protein; WD repeat protein; heat shock protein 60; succinate dehydrogenase; translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72; nucleic acid-binding protein; nucleotide excision repair factor NEF2, RAD23 component; t-complex protein alpha subunit (tcp-1-alpha); k506-binding protein 2; aromatic amino acid aminotransferase; adenylate kinase; alpha-aminoadipate reductase lys1p; coatomer protein subunit alpha; 40s ribosomal protein s21; carbamoyl-phosphate synth; histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily; SAM-dependent RNA methyltransferase; related to 2-hydroxy-3-oxopropionate reductase; transcriptional coactivator p100; 60s ribosomal protein 113a; ornithine carbamoyltransferase; eukaryotic translation initiation factor 5b; aconitate hydratase; RNA 2-o-methyltransferase fibrillarin; t-complex protein beta subunit (tcp-1-beta); voltage-dependent ion-selective channel; coatomer beta subunit; succinate-ligase (adp-forming); carbamoyl-phosphate synthase; related to ste23-metalloprotease involved in a-factor processing; microtubule binding protein; pyridoxalphosphate-dependent enzyme/predicted threonine synthase; fact complex subunit SPT16; SLY1 vesicle trafficking secl-like protein; cytoplasm protein; NADH dehydrogenase; phosphoglycerate kinase; arm repeat-containing protein; ribonuclease III domain; GTP binding protein 4; peptidyl-prolyl cis-trans isomerase b; Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G); eukaryotic polypeptide chain release factor 3; asparagine synthase (glutamine-hydrolyzing); splicing factor U2AF, large subunit (RRM superfamily); NADH-cytochrome b5 reductase; histidine biosynthesis trifunctional-protein; Enoyl-CoA hydratase; alcohol; imidazoleglycerol phosphate synthase; thioredoxin-like fold; ef-hand; electron-transferring-flavoprotein dehydrogenase; MDF1-domain-containing protein; transcription factor IIS, N-terminal; heat shock protein 70; pyruvate carboxylase; homoaconitate hydratase; uncharacterized conserved coiled-coil protein; alternative splicing factor SRp55/B52/SRp75 (RRM superfamily); eukaryotic translation initiation factor 3 subunit 7; threonyl-trna synthetase; RmlC-like jelly roll fold; 60s ribosomal protein 120; mRNA splicing factor; pre-mrna-processing protein 45; atp-dependent rma helicase rrp3; dihydrolipoyllysine-residue acetyltransferase; Acyl-CoA synthetase; ribosomal protein S5; phenylalanyl-tRNA synthetase subunit beta; wd40 repeat-like protein; vacuolar ATP synthase subunit d; phosphatidylserine decarboxylase; vigilin; RNA recognition motif domain; plasma membrane h( )-atpase 1; RRM motif-containing protein; predicted GTPase-activating protein; F1-ATP synthase assembly protein; acetyl-hydrolase; peptidyl-prolyl cis-trans isomerase; antiviral helicase; acetyl CoA carboxylase; age pka protein kinase; ATP-dependent RNA helicase pitchoune; Microtubule-associated protein; cell-cycle nuclear protein, contains WD-40 repeats; phosphoserine aminotransferase; vacuolar protein sorting-associated protein; GMP synthase; translational regulator gcn20-like abc transporter; GDP-mannose pyrophosphorylase; acetyl CoA acyltransferase 2; phosphoketolase; delta 12 fatty acid desaturase; vacuolar protein 8; predicted haloacid-halidohydrolase and related hydrolases; class iii adh enzyme; t-complex protein 1; isocitrate lyase; atpase; 6-phosphogluconolactonase; mitochondrial inner membrane protein; t-complex protein 1 subunit delta; adaptor protein complex ap-1 gamma subunit; rRNA processing protein Rrp5; succinate:fumarate antiporter; predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP); phospho-2-dehydro-3-deoxyheptonate aldolase; RNA-binding domain-containing protein; epsilon DNA polymerase; cullins; asparaginyl-tRNA synthetase; dihydroxy-acid dehydratase; SNARE protein SED5/Syntaxin 5; centromere microtubule binding protein cbf5; histidyl-trna synthetase; endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif; 3-isopropylmalate dehydrogenase; Glycosyl transferase, family 1; eukaryotic translation initiation factor 3 subunit 6; phosphoglycerate mutase family; chromatin remodelling complex ATPase chain; predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); NADH dehydrogenase subunits 2, 5, and related proteins; synaptobrevin-like protein; 40s ribosomal protein s6; ubiquitin C-terminal hydrolase UCHL 1; polyC-binding proteins alphaCP-1 and related KH domain proteins; nucleolar RNA-associated protein (NRAP); WD40 repeat-containing protein; pyruvate decarboxylase; RhoGEF GTPase; Ca2-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain; molecular co-chaperone STI1; vacuolar H-ATPase V1 sector, subunit E; p-loop containing nucleoside triphosphate hydrolase protein; spliceosome subunit; microtubule-binding protein involved in cell cycle control; karyopherin (importin) beta 3; DNA-dependent RNA polymerase ii second largest subunit; coatomer subunit gamma; dehydrogenase kinase; mitochondrial pyruvate dehydrogenase el component beta subunit; glycoside hydrolase family 13 protein; NAD-specific glutamate dehydrogenase; mitochondrial 50s ribosomal protein 13; Ran GTPase-activating protein; FKBP-type peptidyl-prolyl cis-trans isomerase; 60s ribosomal protein 119; small nuclear ribonucleoprotein splicing factor; mannosyltransferase; dUTP pyrophosphatase; GST, gst; glutamate-trna ligase; mov34-domain-containing protein; mitochondrial nuclease; 1,4-benzoquinone reductase-like; thiamine biosynthetic bifunctional enzyme; protein of unknown function DUF3602; upf0041-domain-containing protein; 60s ribosomal protein 111; serine/threonine protein phosphatase 2A, regulatory subunit; argininosuccinate lyase; elongation factor 1 beta delta chain; bar-domain-containing protein; uridylate kinase; phosphatidylethanolamine n-methyltransferase; stomatin family protein; ubiquitin-conjugating enzyme; glycosyltransferase family 2 protein; signal recognition particle protein; B-cell receptor-associated protein and related proteins; RNA-binding S4 domain; Drebrins and related actin binding proteins; small gtpase-binding protein; gtp cyclohydrolase i; ps16 protein; predicted hydrolase related to dienelactone hydrolase; nuclear localization sequence binding protein; SWI SNF complex protein; GTP-binding protein ypt1; ATPase, F0 complex, subunit H; metal resistance protein ycf1; outer membrane protein, MIM1/TOM13, mitochondrial; ubiquitin-protein ligase molybdopterin-converting factor; GTP-binding protein; predicted mitochondrial carrier protein; 28 kda golgi snare protein; dead-domain-containing protein; trehalose-phosphate synthase (UDP-forming); ran protein binding protein; pkinase-domain-containing protein; ribosome recycling factor domain; phosphatase; nucleic acid-binding, GB-fold; ATP-dependent RNA helicase dbp5; mRNA export protein (contains WD40 repeats); protein phosphatase 2A regulatory subunit A and related proteins; glutaminyl-tRNA synthetase; prolactin regulatory element-binding protein/protein transport protein SEC12p; ribosome assembly protein; C4-type Zn-finger protein; exosomal 3-5 exoribonuclease complex subunit Rrp40; transcription regulator HTH, APSES-type DNA-binding domain; RIB7, arfC; 60s ribosomal protein 112; guanylate kinase; predicted membrane protein; glycerol-3-phosphate o-acyltransferase; cactin; translation initiation factor eif3 subunit; biotin holocarboxylase synthetase/biotin-protein ligase; 60s ribosomal protein 123; Inositol monophosphatase; RAS-domain-containing protein; maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31; ribosomal protein S24/S35, mitochondrial, conserved domain; peptide methionine sulfoxide reductase; NAD-dependent formate dehydrogenase; molecular chaperone (DnaJ superfamily); immunoglobulin-like fold; translational repressor pumilio/PUF3 and related RNA-binding proteins (PUF superfamily); urease accessory protein; modular protein with glycoside hydrolase family 13 and glycosyltransferase family 5 domains; orotidine-5-phosphate decarboxylase; phosphoprotein/predicted coiled-coil protein; nucleosome remodeling subunit cafl nurf55 msi1; zinc finger, RING/FYVE/PHD-type; prefoldin subunit 6, KE2 family; thioredoxin h; ADF-like domain-containing protein; alcohol dehydrogenase, class V; 60s ribosomal protein 113; glycoside hydrolase family 3 protein; delta 9 fatty acid desaturase; predicted regulator of rRNA gene transcription (MYB-binding protein); regulator of ribosome synthesis; hexose transport-related protein; protein-histidine kinase; DNA-directed RNA polymerase II subunit I; inositol-3-phosphate synthase; protein transport protein sec22; taurine catabolism dioxygenase TauD/TfdA; ATPase inhibitor, IATP, mitochondria; glycoside hydrolase family 32 protein.
[0211] It will be appreciated that the preceding protein classifications correspond to proteins differentially expressed (based on proteomic analysis) in Xanthophyllomyces dendrorhous strain MYM0 relative to the wild-type strain, with reference to Example 3 and Tables 18 and 19.
[0212] In some typical embodiments, the isolated protein of this aspect is of a protein classification selected from: ferredoxin/adrenodoxin reductase; cytochrome; ATP synthase; NADH dehydrogenase; fatty acid desaturase; Acyl-CoA-oxidase; pantothenate kinase; polyphosphate multikinase; G protein-coupled receptor; and succinate dehydrogenase. In some typical embodiments, the isolated protein of a classification selected from ferredoxin/adrenodoxin reductase; mitochondrial cytochrome b2; cytochrome b; cytochrome c oxidase subunit 1; ATP synthase subunit 6; NADH dehydrogenase subunit 4; cytochrome c oxidase subunit 2; cytochrome c oxidase subunit 3; NADH dehydrogenase subunit 2; NADH dehydrogenase subunit 5; NADH dehydrogenase subunit 6; cytochrome c oxidase subunit 3; delta 9 fatty acid desaturase; Acyl-CoA-oxidase; pantothenate kinase PanK; geranylgeranyl pyrophosphate synthase; fumarate reductase; sucrose transporter; inositol polyphosphate multikinase, ARGR transcription regulatory complex component; G protein-coupled receptor, rhodopsin-like; succinate dehydrogenase; and ATP synthase subunit mitochondrial.
[0213] It will be appreciated that the preceding protein classifications correspond to proteins encoded by one or more nucleotide sequences in which variations considered of particular interest have been identified, with reference to Examples 1 and 2 and Tables 14 and 15.
[0214] A related aspect of the invention provides an antibody or antibody fragment that binds, or has been raised against, an isolated protein of the preceding aspect.
[0215] As used herein an antibody is or comprises an immunoglobulin. The term immunoglobulin includes any antigen-binding protein product of a mammalian immunoglobulin gene complex, including immunoglobulin isotypes IgA, IgD, IgM, IgG and IgE and antigen-binding fragments thereof. Included in the term immunoglobulin are immunoglobulins that are chimeric or humanised or otherwise comprise altered or variant amino acid residues, sequences and/or glycosylation, whether naturally occurring or produced by human intervention (e.g. by recombinant DNA technology).
[0216] Antibody fragments include Fab and Fab2 fragments, diabodies, triabodies and single chain antibody fragments (e.g. scVs), although without limitation thereto. Typically, an antibody comprises respective light chain and heavy chain variable regions that each comprise CDR 1, 2, and 3 amino acid sequences. A typical antibody fragment comprises at least one light chain variable region CDR and/or at least one heavy chain variable region CDR.
[0217] Antibodies and antibody fragments as described herein may be polycolonal or more typically monoclonal. Monoclonal antibodies may be produced using the standard method as for example, described in an article by Kohler & Milstein, 1975, Nature 256, 495, or by more recent modifications thereof as for example described in Chapter 2 of Coligan et al, CURRENT PROTOCOLS IN IMMUNOLOGY, by immortalizing spleen or other antibody producing cells derived from a production species which has been inoculated with an isolated protein or a fragment thereof. It will also be appreciated that antibodies may be produced as recombinant synthetic antibodies or antibody fragments by expressing a nucleic acid encoding the antibody or antibody fragment in an appropriate host cell. Recombinant synthetic antibody or antibody fragment heavy and light chains may be co-expressed from different expression vectors in the same host cell or expressed as a single chain antibody in a host cell. Non-limiting examples of recombinant antibody expression and selection techniques are provided in Chapter 17 of Coligan et al, CURRENT PROTOCOLS IN IMMUNOLOGY and Zuberbuhler et al, 2009, Protein Engineering, Design & Selection 22 169.
[0218] In some embodiments, the antibody or antibody fragment is labelled. The label may be selected from a group including a chromogen, a catalyst, biotin, digoxigenin, an enzyme, a fluorophore, a chemiluminescent molecule, a radioisotope, a drug or other chemotherapeutic agent, a magnetic bead and/or a direct visual label.
[0219] It will be appreciated that the antibody or antibody fragment of this aspect may be used for the detection and/or purification of an isolated protein disclosed herein.
[0220] Another aspect of the invention provides a method of modifying a nucleic acid or protein, including a step of changing one or more nucleotides or amino acids of the nucleic acid or protein, to produce the isolated nucleic acid or the isolated protein of the preceding aspects.
[0221] In embodiments, the method of modifying the nucleic acid or protein according to this aspect is a method of mutagenizing the nucleic acid or protein, or a nucleic acid encoding the protein.
[0222] In some typical embodiments, the method according to this aspect includes a step of mutagenising a cell or an organism to induce mutations in the genetic material of the cell or organism, to thereby modify the nucleic acid or protein.
[0223] The cell may be prokaryotic cell, such as a bacterial cell. In some typical embodiments, the bacterial cell is a Paracoccus cell. The Paracoccus cell may be Paracoccus carotinifaciens.
[0224] The cell may be eukaryotic cell, such as a plant cell, an animal cell, an algal cell, and a fungal cell.
[0225] In some typical embodiments, the algal cell is a microalgae cell. The microalgae cell may be a Haematococcus cell. In embodiments, the Haematococcus cell is Haematococcus pluvialis.
[0226] In some typical embodiments of the fungal cell is a yeast cell. The yeast cell may be a Xanthophyllomyces cell. In some typical embodiments, the Xanthophyllomyces cell is Xanthophyllomyces dendrorhous.
[0227] The terms mutant, mutation and mutated are used herein generally to encompass synonymous, non-synonymous, conservative, and nonconservative nucleic acid base pair substitutions, deletions and/or insertions introduced into genetic material. For example, mutations may be introduced into chromosomal DNA and genomic DNA, RNA such as unspliced and spliced mRNA, tRNA and other forms of genetic material as are known in the art.
[0228] Mutagenesis of the genetic material of an organism may result in introduction of mutations in one or a plurality of nucleic acid molecules. Genome-wide mutagenesis of organisms is well-known in the art. In alternative embodiments, mutations can be introduced or induced by targeting specific loci or regions. It will be appreciated that gain-of-function and loss-of-function mutations may be achieved as a result of mutagenesis, although without limitation thereto.
[0229] Mutations may be induced or introduced using either non-specific methods such as random mutagenesis or alternatively by using specific methods such as targeted mutagenesis. Induced mutations may include single- or multiple-nucleotide substitutions, deletions and/or insertions, either alone or in combination. Mutagenesis methods of the present invention are inclusive of in vitro, in vivo and in situ methodology.
[0230] Chemical mutagenesis is a useful method of genome-wide random mutagenesis methods using alkylating agents such as ethylmethanesulfonate (EMS) and dimethyl sulfate (DMS) or other chemical mutagens such as ethidium bromide, formic acid, hydrazine, sodium bisulphite, and diepoxybutane.
[0231] Physical mutagenesis using physical mutagens as for example irradiation using ionising radiation (such as , or X-ray radiation), UV irradiation and fast neutron irradiation of cells may also be used for genome-wide random mutagenesis. It will be appreciated by a person skilled in the art that the time and dosage of exposure of the cell or organism, to a mutagen is dependent on the cell, organism, and mutagen that is used and can be readily determined by a skilled person.
[0232] Mutations may be introduced into nucleic acids by random or site-directed mutagenesis as are well known in the art. Non-limiting examples of nucleic acid mutagenesis methods are provided in Chapter 8 of CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds Ausubel et al., (John Wiley & Sons, Inc. 1995-2008).
[0233] Mutagenesis methods can also include incorporation of dNTP analogs into nucleic acids (Zaccolo et al., 1996, J. Mol. Biol. 255 589) and PCR-based random mutagenesis such as described in Stemmer, 1994, Proc. Natl. Acad. Sci. USA 91 10747 or Shafikhani et al., 1997, Biotechniques 23 304. It is further noted that PCR-based random mutagenesis kits have been made commercially available, such as the Diversify kit (Clontech).
[0234] Mutations produced by a nucleic acid sequence amplification-based technique may be introduced into the genetic material of a cell.
[0235] As used herein, a nucleic acid sequence amplification technique includes but is not limited to polymerase chain reaction (PCR) as for example described in Chapter 15 of CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds. Ausubel et al. (John Wiley & Sons NY USA 1995-2001) strand displacement amplification (SDA); rolling circle replication (RCR) as for example described in International Application WO 92/01813 and International Application WO 97/19193; nucleic acid sequence-based amplification (NASBA) as for example described by Sooknanan et al. 1994, Biotechniques 17 1077; ligase chain reaction (LCR) as for example described in International Application WO89/09385 and Chapter 15 of CURRENT PROTOCOLS IN MOLECULAR BIOLOGY supra; Q- replicase amplification as for example described by Tyagi et al., 1996, Proc. Natl. Acad. Sci. USA 93 5395 and helicase dependent amplification as for example described in International Publication WO 2004/02025.
[0236] Region-specific mutagenesis and directed mutagenesis using PCR may also be employed to construct nucleic acid mutants according to the invention. Oligonucleotide mediated (or site-directed) mutagenesis may also be used. A non-limiting example of oligonucleotide-mediated site-directed mutagenesis procedures to introduce small clusters of point mutations throughout a target region is provided in Ausubel et al., supra. Briefly, mutations are introduced into a sequence by annealing a synthetic oligo nucleotide containing one or more mismatches to the sequence of interest cloned into a single-stranded M13 vector. This template is grown in an Escherichia coli dut- ung- strain, which allows the incorporation of uracil into the template strand. The oligonucleotide is annealed to the template and extended with T4 DNA polymerase to create a double-stranded heteroduplex. Finally, the heteroduplex is introduced into a wild-type E. coli strain, which will prevent replication of the template strand due to the presence of apurinic sites (generated where uracil is incorporated), thereby resulting in plaques containing only mutated DNA. It is also noted that site-directed mutagenesis kits have been made commercially available, such as the QuikChange kit (Stratagene).
[0237] Alternatively, linker-scanning mutagenesis of DNA may be used to introduce clusters of point mutations throughout a sequence of interest that has been cloned into a plasmid vector. For example, reference may be made to Ausubel et al., supra, (in particular, Chapter 8) which describes a first protocol that uses complementary oligonucleotides and requires a unique restriction site adjacent to the region that is to be mutagenised. A nested series of deletion mutations is first generated in the region. A pair of complementary oligonucleotides is synthesised to fill in the gap in the sequence of interest between the linker at the deletion endpoint and the nearby restriction site. The linker sequence provides the desired clusters of point mutations as it is moved or scanned across the region by its position at the varied endpoints of the deletion mutation series.
[0238] Mutations may also be induced or introduced by insertion of one or a plurality of nucleotides or base pairs into the genetic material. Transposon and retrotransposon mutagenesis (for example as described in Walbot 2000, Curr Opin Plant Biol 3 103; U.S. Pat. No. 6,720,479; Voytas 1996, Genetics 142 569) are possible methods for insertional mutagenesis. Other methods of insertional mutagenesis include targeted methods such as homologous recombination and site-specific recombination. A non-limiting example of homologous recombination is the T-DNA system (for example as described in Wang et al. 2001, Gene 272 249; and Iida & Terada 2005, Plant Mol. Biol. 59 205). An example of site-specific recombination is the cre-lox recombination system of bacteriophage P1. Chimeric RNA/DNA oligonucleotide-directed gene targeting is also a useful technique for the generation of site-specific point mutations such as deletions, insertions and/or base changes in higher organisms including plants (see for example as described in Iida & Terada, 2005, Plant Mol. Biol. 59 205; and Rice et al., 2000, Plant Physiol, 123 427).
[0239] Mutations may also be introduced by deletional mutagenesis of one or a plurality of nucleotides, or a region of a genetic locus. For example, fast neutron deletion mutagenesis can be effective for genome-wide deletional mutagenesis method and utilises fast neutron bombardment to create randomly mutagenised populations, and more particularly knockout mutations such as described Li et al., 2002, Comp. Funct. Genomics 3 158. It will be appreciated that targeted deletional mutagenesis may be achieved by using a variety of other nucleic acid-based mutagenesis methods as herein described, such as, but not limited to oligonucleotide-based mutagenesis.
[0240] Targeting Induced Local Lesions in Genomes (TILLING) is particularly amenable for random mutagenesis to generate point mutations in many organisms. TILLING combines traditional chemical mutagenesis following by high-throughput screening for point mutations. Reference is made to McCallum et al., 2000, Nat. Biotechnol. 18 455; Till et al., 2003, Methods Mol. Biol. 236 205; Henikoff et al., 2004, Plant Physiol. 135 630; and Till et al., 2003, Genome Res. 13 524 for non-limiting examples of TILLING methods that may be applicable to the present invention.
[0241] In certain embodiments, mutations are introduced into the genetic material of a cell or organism via genome editing.
[0242] Genome editing is a method for mutagenesis in which DNA is inserted, substituted, modified, or deleted from the genetic material of an organism in a targeted manner, typically using engineered nucleases.
[0243] Methods for genome editing include zinc finger nuclease methods, as described for example by Miller et al., 2007, Nat. Biotech. 25 778; CRISPR Cas methods, as described for example by Cong et al., Science 339 819; and TALEN methods, as described for example by Bedell et al., Nature 491, 114.
[0244] As will be understood by those skilled in the art, genome editing typically comprises the transformation of a cell or tissue with one or more genetic constructs facilitating the expression of: [0245] (i) one or more DNA nucleases; and [0246] (ii) one or more molecules that guide the cleavage of DNA at a targeted region within the genetic material of an organism by said nuclease(s).
[0247] Targeted DNA breaks are thereby induced in the genetic material of the organism. These targeted DNA breaks are generally double stranded DNA breaks, although without limitation thereto.
[0248] In embodiments of genome editing wherein a zinc finger nuclease method is used, the one or more molecules that guide the cleavage of DNA at a targeted region within the genetic material of an organism by the nuclease(s) are proteins comprising a zinc finger DNA-binding domain. Generally, a plurality of the proteins are fused to the nuclease (s), and the plurality of zinc finger DNA-binding domains of the proteins bind with at least partial specificity to the targeted region, and thereby induce cleavage of the targeted region by the nuclease (s).
[0249] In embodiments of genome editing wherein a TALEN method is used, the one or more molecules that guide the cleavage of DNA at a targeted region within the genetic material of an organism by the nuclease(s) are proteins comprising a transcription activator-like effector DNA-binding (TALE) domain. Generally, a plurality of the proteins are fused to the nuclease (s), and the plurality of TALE DNA-binding domains of the proteins bind with at least partial specificity to the targeted region, and thereby induce cleavage of the targeted region by said nuclease(s).
[0250] In embodiments of genome editing wherein a CRISPR/Cas method is used, the nuclease is a CRISPR-associated (Cas) nuclease, and the one or more molecules that guide the cleavage of DNA at a targeted region is a guide RNA molecule (or gRNA) with homology to the targeted region. Generally, the gRNA molecule forms a complex with the Cas nuclease and guides binding of the Cas nuclease to the targeted region with at least partial specificity, and thereby induces cleavage of the targeted region by the Cas nuclease.
[0251] It will be further understood that targeted DNA breaks induced during genome editing can facilitate non homologous end joining or homology-dependent repair.
[0252] Non-homologous end joining is a cellular mechanism for DNA break repair wherein cleaved DNA ends are ligated, which is typically error prone, i.e. introduces nucleotide sequence variation, e.g. insertions or deletions, at the site of the DNA break. DNA breakage followed by error-prone non-homologous end joining induced by genome editing can be used to inactivate targeted regions within the genetic material of organisms (as described for example by Gaj et al., 2013 Trends Microbiol. 31 397).
[0253] Homology-dependent repair is a cellular mechanism for DNA break repair wherein a nucleic acid possessing homology to the region surrounding a DNA break is used as a template for repair of the DNA break. Genome editing can be used to introduce nucleic acid variants into targeted regions within the genetic material of organisms (as described for example by Gaj et al., 2013 Trends Microbiol 31 397) by inducing DNA breakage followed by homology-dependent repair in the presence of a donor molecule, wherein said donor molecule comprises homology to the region surrounding the DNA break.
[0254] As will be understood by those skilled in the art, genome editing comprising homology-dependent repair can be used for allele replacement, wherein a nucleic acid sequence of the genetic material of an organism is substituted, exchanged, or replaced with a variant or variation of the nucleic acid sequence.
[0255] In some typical embodiments, the step of mutagenising a cell or organism to induce mutations in the genetic material of the cell or organism to thereby modify the nucleic acid or protein according to this aspect is a step of randomly mutagenising the cell using a chemical and/or physical mutagen.
[0256] In some typical embodiments, the chemical mutagen is or includes N-methyl-N-nitro-N-nitrosoguanidine and/or ethyl methanesulfonate.
[0257] In some typical embodiments, the physical mutagen is or includes ultra violet light.
[0258] Another aspect of the invention provides a nucleic acid vector or construct comprising the isolated nucleic acid of the invention, and one or more additional nucleotide sequences. Typically, the genetic construct is in the form of, or comprises genetic components of, a plasmid, bacteriophage, cosmid, or yeast or bacterial artificial chromosome, as are well known in the art.
[0259] Genetic constructs may be suitable for maintenance and propagation of the isolated nucleic acid in bacteria or yeast or other host cells, for manipulation by recombinant DNA technology and/or expression of the nucleic acid or an encoded protein.
[0260] For the purposes of host cell expression, the genetic construct will be an expression construct. Suitably, the expression construct comprises one or more isolated nucleic acids or fragments disclosed herein operably linked to one or more additional sequences in an expression vector.
[0261] It will be understood that an expression vector may be either a self-replicating extra-chromosomal vector such as a plasmid, or a vector that integrates into a host genome.
[0262] By operably linked is meant that said additional nucleotide sequence(s) is/are positioned relative to the isolated nucleic acid, typically to initiate, regulate or otherwise control transcription.
[0263] In some embodiments, the additional nucleotide sequences are regulatory sequences. Regulatory nucleotide sequences will generally be appropriate for the host cell used for expression. Numerous types of appropriate expression vectors and suitable regulatory sequences are known in the art for a variety of host cells.
[0264] The one or more regulatory nucleotide sequences may include, but are not limited to, promoter sequences, leader or signal sequences, ribosomal binding sites, transcriptional start and termination sequences, translational start and termination sequences, and enhancer or activator sequences.
[0265] Constitutive or inducible promoters as known in the art may be used. The promoters may be either naturally occurring promoters, or hybrid promoters that combine elements of more than one promoter.
[0266] In some embodiments, the additional nucleotide sequence is a selectable marker gene to allow the selection of transformed host cells. Selectable marker genes are well known in the art and will vary with the host cell used.
[0267] The expression construct may also include an additional nucleotide sequence encoding a fusion partner (typically provided by the expression vector) so a protein of the invention is expressed as a fusion protein, as hereinbefore described.
[0268] By way of example only, an isolated protein of the invention may be produced by a method including the steps of: [0269] (i) preparing an expression construct which comprises an isolated nucleic acid of the invention, operably linked to one or more regulatory nucleotide sequences; [0270] (ii) transfecting or transforming a suitable host cell with the expression construct; [0271] (iii) expressing a recombinant protein in said host cell; and [0272] (iv) isolating the recombinant protein from said host cell.
[0273] Suitable host cells for expression may be prokaryotic or eukaryotic. For example, suitable host cells may be mammalian cells, plant cells, yeast cells, insect cells or bacterial cells. In some typical embodiments, the host cell for expression of an isolated protein according to the invention is a bacterial cell. In some typical embodiments, the host cell for expression of an isolated protein according to the invention is an algal cell. In some typical embodiments, the host cell for expression of an isolated protein according to the invention is a yeast cell.
[0274] Introduction of genetic constructs into host cells (whether prokaryotic or eukaryotic) is well known in the art, as for example described in CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds. Ausubel et al, (John Wiley & Sons, Inc. 1995-2009), in particular Chapters 9 and 16.
[0275] Recombinant proteins may be conveniently prepared by a person skilled in the art using standard protocols as for example described in Sambrook, et al, MOLECULAR CLONING. A Laboratory Manual (Cold Spring Harbor Press, 1989), in particular Sections 16 and 17; CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds. Ausubel et al, (John Wiley & Sons, Inc. 1995-2009), in particular Chapters 10 and 16; and CURRENT PROTOCOLS IN PROTEIN SCIENCE Eds. Coligan et al, (John Wiley & Sons, Inc. 1995-2009), in particular Chapters 1, 5 and 6.
[0276] It will further be understood that, in some typical embodiments, the vector or construct of this aspect is a gene silencing or gene regulating vector or construct.
[0277] It will be appreciated by the skilled person that gene silencing or gene regulating vectors or constructs of the invention are typically adapted to produce non-coding sequences with the capacity to silence or regulate gene expression. Typically, the non-coding sequences are small RNA sequences.
[0278] As used herein, small RNA will be understood to refer to small, non-coding RNA molecules that have the capacity to bind to and regulate the expression, translation and/or replication of other nucleic acid molecules. The skilled person is directed to Ipsaro, J. J., & Joshua-Tor, L., 2015, Nature Struc. & Mol. Biol. 22 20 for summary of small, non-coding RNA molecules.
[0279] It will be understood that, as used herein, the term small RNA encompasses all such molecules, regardless of the particular name that may be used in a scientific or research context. By way of non-limiting example, the skilled person will readily appreciate that, as used herein, the term small RNA encompasses small non-coding RNA molecules referred to as miRNA and siRNA.
[0280] It will be further understood that small RNA molecules generally have a high degree of nucleotide sequence identity with a nucleic acid molecule for which they have the capacity to bind to and regulate the expression, translation, and/or replication of However, it will also be understood that a small RNA molecule need not necessarily have 100% identity to such a sequence.
[0281] Nucleic acid vectors and constructs for gene silencing or regulation using small RNA molecules are widely available in a range of forms, as is well-known in the art.
[0282] In some typical embodiments, the gene silencing or gene regulating vector or construct is adapted for transformation of yeast. For a recent review of small RNA-based gene regulation for strain engineering in yeast, the skilled person is directed to Chen et al. Front. Bioeng. Biotechnol., 2 Jul. 2020 doi.org/10.3389/fbioe.2020.00731.
[0283] It will also be understood that, in some typical embodiments, the vector or construct of this aspect is a genome editing construct. Details of genome editing and constructs therefor is provided hereinabove.
[0284] In some typical embodiments, the editing construct is adapted for genome editing in yeast. For recent review of genome editing approaches in yeast, the skilled person is directed to Yang, Z., & Blenner, M. (2020). Genome editing systems across yeast species. Current Opinion in Biotechnology, 66, 255-266.
[0285] Another aspect of the invention provides a cell comprising the nucleic acid, protein, or vector or construct of the preceding aspects.
[0286] In some embodiments, the cell of this aspect is a prokaryotic cell. The prokaryotic cell may be a bacterial cell. The bacterial cell may be Gram-negative or Gram-positive. The bacterial cell may be aerobic, anaerobic, or facultatively anaerobic.
[0287] In embodiments, the bacterial cell is of the order Enterobacterales. In embodiments, the bacterial cell is of the family Enterobacteriaceae. In embodiments, the bacterial cell is of the genus Escherichia. In an embodiment, the bacterial cell is Escherichia coli.
[0288] In embodiments, the bacterial cell is of the order Caulobacterales. In embodiments, the bacterial cell is of the family Caulobacteraceae. In embodiments, the bacterial cell is of the genus Brevundimonas. In an embodiment, the bacterial cell is Brevundimonas vesicularis.
[0289] In embodiments, the bacterial cell is of the order Sphingomonadales. In embodiments, the bacterial cell is of the family Sphingomonadaceae. In embodiments, the bacterial cell is of the genus Sphingomonas. In an embodiment, the bacterial cell is Sphingomonas astaxanthinifaciens.
[0290] In embodiments, the bacterial cell is of the order Rhodobacterales. In embodiments, the bacterial cell is of the family Rhodobacteraceae. In embodiments, the bacterial cell is of the genus Paracoccus. In a typical embodiment, the Paracoccus cell is Paracoccus carotinifaciens.
[0291] In some typical embodiments, the cell is a eukaryotic cell. The eukaryotic cell may be selected from an animal cell, a plant cell, an algal cell, and a fungal cell.
[0292] The animal cell may be a marine animal cell. The animal cell may be a crustacean cell. In embodiments, the animal cell is prawn cell or shrimp cell. In embodiments, the animal cell is a krill cell.
[0293] The plant cell may be an angiosperm cell. The plant cell be a monocot or a dicot cell. The plant cell may be an algal cell. The algal cell may be a microalgae cell.
[0294] In embodiments, the plant cell is of the order Ranunculales. In embodiments, the plant cell is of the family Ranunculaceae. In a typical embodiment, the plant cell is of the genus Adonis. The plant cell may be of a species selected from Adonis aestivalis, Adonis aleppica, Adonis amurensis, Adonis annua, Adonis bobroviana, Adonis chrysocyathus, Adonis coerulea, Adonis Cyllene, Adonis davidii, Adonis dentata, Adonis distorta, Adonis flammea, Adonis macrocarpa, Adonis nepalensis, Adonis palaestina, Adonis pyrenaica, Adonis ramose, Adonis sibirica, Adonis sutchuenensis, Adonis tianschanica, Adonis vernalis, and Adonis volgensis.
[0295] In some embodiments, the algal cell is a microalgae cell. In embodiments, the microalgae cell is of the order Chlamydomonadales. In embodiments, the microalgae cell is of the family Haematococcaceae. In embodiments, the microalgae cell is of the genus Haematococcus. In a typical embodiment, the microalgae cell is Haematococcus pluvialis.
[0296] Typically, the cell is a fungal cell. More typically, the cell is a yeast cell.
[0297] In embodiments, the yeast cell is of the order Saccharomycetales. In embodiments, the yeast cell is of the family Saccharomycetaceae. In embodiments, the yeast cell is of the genus Saccharomyces. In an embodiment, the yeast cell is Saccharomyces cerevisiae.
[0298] In embodiments, the yeast cell is of the family Dipodascaceae. In embodiments, the yeast cell is of the genus Yarrowia. In an embodiment, the yeast cell is Yarrowia lipolytica.
[0299] In embodiments, the yeast cell is of the order Cystofilobasidiales. In embodiments, the yeast cell is of the family Cystofilobasidiaceae. In an embodiment, the yeast cell is of the genus Xanthophyllomyces. In a typical embodiment, the cell is Xanthophyllomyces dendrorhous.
[0300] A related aspect provides an organism comprising the cell of the preceding aspect. The organism may be any suitable organism inclusive of bacteria, plant, algae, animal, fungi, and yeast organisms.
[0301] In some typical embodiments, the organism is an algal strain. More typically, the organism is a yeast strain. Exemplary yeast strains according to this aspect include mutant strains MAMY3, MAMY6, MB18, MB24, MYM0, MYM6, MYM44, and MYM92 as described in Example 1.
[0302] It will be appreciated that the cell or organism according to this aspect may be a cell or organism produced according to the mutagenesis approaches for modifying nucleic acid or proteins as hereinabove described.
[0303] Another aspect of the invention provides a method of co-cultivating a cell or organism according to the preceding aspect with a further cell or organism. The further cell or organism may be any suitable cell or organism, including prokaryotic or eukaryotic cells and organisms. In some typical embodiments, the further cell or organism is an algal cell or organism. Typically, the algal cell or organism is a microalgae cell or organism. In a typical embodiment, the microalgae cell or organism is Haematococcus pluvialis.
[0304] Another aspect of the invention provides a method of producing astaxanthin including a step of expressing the isolated nucleic acid or the isolated protein of the preceding aspects, to thereby produce the astaxanthin.
[0305] The expression of the isolated nucleic acid or the isolated protein according to the method of this aspect may be in vitro expression, in vivo expression, or in situ expression. In embodiments, the isolated nucleic acid or isolated protein is expressed in a cell or organism, to thereby produce the astaxanthin. The cell or organism may be a prokaryotic, eukaryotic, animal, plant, algal, microalgal, fungal, or yeast cell or organism as set out in the preceding aspects. Typically, the cell or organism according to the method of this aspect is selected from a bacterial cell or organism, an algal cell or organism, a fungal cell or organism, and a yeast cell or organism.
[0306] In some typical embodiments, the method of this aspect includes a step of expressing the isolated nucleic acid or the isolated protein in a bacterial cell, to thereby produce the astaxanthin. In embodiments, the bacterial cell is a Paracoccus cell. The Paracoccus cell may be Paracoccus carotinifaciens.
[0307] In some typical embodiments, the method of this aspect includes a step of expressing the isolated nucleic acid or the isolated protein in a microalgae cell, to thereby produce the astaxanthin.
[0308] The microalgae cell may be a Haematococcus cell. In embodiments, the Haematococcus cell is Haematococcus pluvialis.
[0309] In some typical embodiments, the method of this aspect includes a step of expressing the isolated nucleic acid or the isolated protein in a fungal cell or, more typically, a yeast cell, to thereby produce the astaxanthin. The yeast cell may be a Xanthophyllomyces cell. Typically, the Xanthophyllomyces cell is Xanthophyllomyces dendrorhous.
[0310] In some typical embodiments, the astaxanthin is produced according to the method of this aspect at an increased or enhanced level or rate by expression of the isolated nucleic acid or isolated protein, as compared to a level or rate by expression of a corresponding wild-type nucleic acid or protein. Suitably, the corresponding wild-type nucleic acid or protein is a nucleic or protein of wild-type Xanthophyllomyces dendrorhous strain CBS 6938.
[0311] In some typical embodiments, the level or rate of expression of astaxanthin is increased or enhanced at least about 5%, 10%, 15%, 20%, 25%, 50%, 75%, 100%, 150%, 200%, 300%, 400%, 500%, 600%, 700%, 800%, 900%, 1000%, 1500%, 2000%, 3000%, 4000%, or 5000%, as compared to the level or rate by expression of the corresponding wild-type nucleic acid or protein.
[0312] Another aspect of the invention provides a method of producing astaxanthin including a step of performing metabolism with a cell or organisms expressing an isolated nucleic acid, isolated protein, or vector or construct as hereinabove described, to thereby produce the astaxanthin.
[0313] In embodiments, the cell or organism according to this aspect is a prokaryotic, eukaryotic, animal, plant, algal, microalgal, fungal, or yeast cell or organism as hereinabove described. More typically, the cell or organism according to the method of this aspect is selected from a bacterial cell or organism, an algal cell or organism, a fungal cell or organism, and a yeast cell or organism.
[0314] In some typical embodiments, the cell is a Paracoccus bacterial cell. More typically, the bacterial cell is a Paracoccus carotinifaciens cell.
[0315] In some typical embodiments, the cell is Haematococcus algal cell. More typically, the algal cell is a Haematococcus pluvialis cell.
[0316] In some typical embodiments, the yeast cell is a Xanthophyllomyces cell. More typically, the yeast cell is a Xanthophyllomyces dendrorhous.
[0317] Typically, the step of performing metabolism with the cell or organism according to this aspect to produce the astaxanthin is a step of performing fermentation with the cell or organism.
[0318] Typically, the method of this aspect includes a step of combining the cell or organism with one or more metabolites.
[0319] In some typical embodiments, the one or more metabolites comprise a nitrogen source metabolite. Typically, the nitrogen source metabolite is selected from urea, ammonium sulphate, yeast extract, malt extract, bactopeptone, and dried corn steep liquor. More typically, the nitrogen source metabolite is or comprises malt extract.
[0320] In some typical embodiments, the one or more metabolites comprise a carbon source metabolite. Typically, the carbon source metabolite is selected from molasses, glucose, glycerol, and sucrose. More typically, the carbon source metabolite is or comprises molasses.
[0321] In some typical embodiments, the astaxanthin is produced according to the method of this aspect at an increased or enhanced level or rate by metabolism with the cell expressing the isolated nucleic acid, isolated protein, or vector or construct, as compared to a level or rate by metabolism of a corresponding wild-type cell or organism. In some typical embodiments, the corresponding wild-type cell organism is, or is of, Xanthophyllomyces dendrorhous strain CBS 6938.
[0322] In some typical embodiments, the level or rate of expression of astaxanthin is increased or enhanced at least about 5%, 10%, 15%, 20%, 25%, 50%, 75%, 100%, 150%, 200%, 300%, 400%, 500%, 600%, 700%, 800%, 900%, 1000%, 1500%, 2000%, 3000%, 4000%, or 5000%, as compared to the level or rate by metabolism of the corresponding wild-type cell.
[0323] In relation to aspects of the invention that can result in increased or enhanced astaxanthin production as hereinabove described, it will be appreciated with reference to Example 1 and Example 2, that increases of astaxanthin production of approaching 50 times (i.e. 5000%) have been achieved using mutant Xanthophyllomyces dendrorhous strains of the invention.
[0324] Another aspect of the invention provides a non-astaxanthin by-product or secondary product of the method of the preceding aspect.
[0325] The skilled person will readily appreciate that cellular metabolism to produce astaxanthin will typically produce a variety of by-products. In embodiments, the by-product according to this aspect is a by-product of fermentation.
[0326] In a typical embodiment, the by-product according to this aspect is an invertase enzyme. The skilled person will appreciate that invertase converts sucrose to glucose and fructose, and is one of the most widely used enzymes in food industry. Invertase is industrially produced by yeast fermentation, such that it could be desirable to produce invertase in conjunction with astaxanthin using the method of the preceding aspect.
[0327] Another aspect of the invention provides a formulation comprising the cell (or part thereof), organism (or part thereof), astaxanthin, and/or by-product of the preceding aspects. The formulation will suitably include one or more other components inclusive of buffers, excipients, and diluents, and/or one or more additional active agents.
[0328] In some typical embodiments, the formulation of this aspect is a substantially dry formulation, such as a granular or powdered formulation. Typically, the substantially dry formulation comprises astaxanthin.
[0329] In some typical embodiments, the formulation of this aspect is a liquid or semi-liquid formulation, such as an aqueous or oil-based formulation. Typically, the liquid or semi-liquid formulation comprises astaxanthin.
[0330] In some typical embodiments, the formulation of this aspect is a solid or semi-solid formulation, such as an oleoresin or encapsulated oleoresin formulation. Typically, the solid or semi-solid formulation comprises astaxanthin.
[0331] In some typical embodiments, the formulation of this aspect, such as the substantially dry formulation, liquid or semi-liquid formulation, or solid or semi-solid formulation, comprises cell wall derivatives of the cell (such as the plant cell or more typically the yeast cell) of the cell or organism according to the invention as herein described.
[0332] The formulation of this aspect may be adapted for administration to or consumption by an animal.
[0333] In some typical embodiments, the formulation is adapted for administration to or consumption by a farmed animal. The farmed animal may be an aquaculture animal, typically a seafood aquaculture animal.
[0334] In some typical embodiments, the formulation is adapted for administration to or consumption by a pet animal, a domestic animal, or a companion animal. The pet animal, domestic animal, or companion animal may be a feline animal (e.g. cat), a canine animal (e.g. dog), or an equine animal (e.g. horse). The formulation may be a pet food formulation or the like.
[0335] In some typical embodiments, the formulation is adapted for administration to or consumption by a human. The formulation adapted for consumption by a human may comprise protein. In some typical embodiments, the formulation is an astaxanthin-supplemented protein formulation such as a protein bar, protein drink, or protein powder, or the like.
[0336] In some typical embodiments, the formulation of this aspect comprises beta-glucans.
[0337] In some typical embodiments, the formulation of this aspect comprises polyphenols.
[0338] Another aspect of the invention provides a method of supplementing an animal with the astaxanthin or formulation according to the preceding aspects.
[0339] In some typical embodiments of this aspect, the animal supplemented according to the method of this aspect is a farmed animal. Typically, the farmed animal is an aquaculture animal. Typically, the aquaculture animal is a crustacean or a fish. In some typical embodiments, the crustacean is selected from shrimp, krill, crab, and crayfish. In some typical embodiments, the fish is selected from salmon and trout. A related aspect provides a farmed animal product produced by or from a farmed animal, such as a seafood animal, supplemented according to the method of this aspect.
[0340] In some typical embodiments, the animal supplemented according to the method of this aspect is a pet animal, a domestic animal, or a companion animal. Typically, the pet animal, domestic animal, or companion animal is selected from a feline animal (e.g. domestic cat), a canine animal (e.g. domestic dog), and an equine animal (e.g. domestic horse).
[0341] In some typical embodiments, the supplemented animal is a human.
[0342] Another aspect of the invention provides a method of treating or preventing a disease or disorder in a subject, including a step of administering the astaxanthin or formulation according to the preceding aspects to the subject. Suitably, the subject is an animal subject. Typically, the animal subject is a human.
[0343] In some typical embodiments, the disease or disorder treated according to the method of this aspect is a wound. The method according to this aspect may be a method of treating, alleviating symptoms or, or controlling infection in a wound. The administration may be topical administration to the wound and/or oral administration to the subject.
[0344] A related aspect provides use of the astaxanthin, by-product, or secondary product according to the preceding aspect in the manufacture of a formulation, composition, or medicament for the treatment of a disease or disorder in a subject.
EXAMPLES
Example 1: Enhanced Astaxanthin Production in Mutant Xanthophyllomyces dendrorhous Strains
[0345] Astaxanthin (AX) is a potent antioxidant with increasing biotechnological and commercial potential as a feed supplement. AX is also known for giving salmonids and crustaceans their characteristic pink colour. The red yeast Xanthophyllomyces dendrorhous (previously known as Phaffia rhodozyma) naturally produces AX as its main fermentation product but wild-type strains and those previously generated through classical random mutagenesis produce relatively low yields of AX, such that existing strains do not meet desired commercial requirements.
[0346] This example describes X. dendrorhous CBS 6938 mutant strains generated through chemical and ultraviolet radiation mutagenesis in combination with screening, the strains exhibiting comparatively high AX production. Additionally, this example describes enhancement of mutant X. dendrorhous strain AX production using culture media optimization and fed-batch culture kinetic modelling. Under optimised conditions, an approximately 50-fold increase in AX production as compared to the wild-type strain has been achieved, with a total biomass of around 100 gDCW/L and a carotenoid production of 1 g/L.
[0347] This example further describes whole genome sequencing of eight X. dendrorhous mutant strains showing substantially increased AX production to identify genomic changes. Genomic variant analyses found 368 conserved mutations across the selected strains with notable mutations including those identified in regulators and catalysts of AX precursors in the mevalonate pathway, the electron transport chain, oxidative stress mechanisms, and carotenogenesis.
Materials and Methods
Strains, Media, and Growth Conditions
[0348] The wild-type strain of X. dendrorhous CBS 6938 was obtained from the CBS Fungal Biodiversity Centre culture collection. The strain was kept on agar plates at 4 C. for short term storage of up to one month or glycerol stock (glycerol 20%) at 80 C. for long term storage. YM media containing (g/L): yeast extract (3), malt extract (3), bactopeptone (5), and sucrose (20) as a carbon source was used for routine liquid culture and inoculum preparation. Agar (15 g/L) was supplemented to prepare YM agar plates. When specified, YM media was buffered with potassium hydrogen phthalate (20 g/L). For flask fermentations, 50 mL of liquid YM media in a 250 mL shake-flask was cultured on a rotary shaker at 250 rpm and 20 C. Flasks for fermentation were inoculated with a pre-culture growing at the mid-exponential phase by using 10% of inoculum at A600.
Analytic Techniques
Optical Density (A600)
[0349] The absorbance of cultures with X. dendrorhous was measured at 600 nm in a spectrophotometer. The sample was diluted within a range of 0.1-1 absorbance units.
Dried Cell Weight
[0350] One to two millilitres of cells were vacuum filtered using a Millipore HAWP04700 filter (pore size of 0.45 m and diameter of 47 mm) with the filter humidified with distilled water before filtrating the cells. The filter with filtered cells was then dried in an oven at 80 C. for 48 h and weighed. The difference between the weight of the filter with and without cells, and the volume taken as a sample, were used to calculate the dried cell weight, represented as gDCW/L.
Total Carotenoids
[0351] The DMSO technique was used to determine the total carotenoids of samples (Sedmak et al., 1990). For this, 5-50 pL of sample was placed into a 2 mL Eppendorf tube and centrifuged at 14,000 rpm for 1 min, in which the supernatant was discarded and the pellet kept. The cells were then washed two times with distilled water. Next, 0.5 mL of heated DMSO at 55 C. was added to the pellet and vortexed for 30 s. To ensure total disruption, the cells were incubated for an additional five minutes at 55 C. and vortexed again for 30 sec. Next, 0.1 mL of 0.01 M sodium phosphate at pH 7 and 1 mL of 1:1 hexane:ethyl acetate was added, followed by vortexing for 30 s. The tube was then centrifuged at 14,000 rpm for 1 min to separate the solution into two phases. Finally, 0.7 mL of the organic phase (the phase on the top with the pigments) was transferred into a 700 pL Quartz Cuvette to measure absorbance at 480 nm. The total carotenoids were calculated with the following equation:
A480: Absorbance at 480 nm; V1: Volume of the organic phase, mL; E: Extinction coefficient of 2150; L: Length of the Quartz Cuvette (generally 1 cm); V2: Volume of the sample, mL.
Hplc Analyses for Astaxanthin and Other Carotenoids
[0352] The samples were obtained using the DMSO extraction method for total carotenoid analyses. Samples and standards were diluted in hexane:ethyl acetate 1:1 (v/v) before injection of 30 pL. The column was a Luna 3 pm Silica (2) 100 A, LC Column 1504.6 mm (Phenomenex Cat. No. 00F-4162-E0). The column was equipped with a security guard cartridge holder (Phenomenex Cat. No. KJO-4282) and a security guard cartridge Silica 43 mm ID (Phenomenex Cat. No. AJO-4348) so as to extend lifespan. The mobile phase was a mixture of hexane:acetone (82:18, v/v) which was injected at a flow rate of 1.2 mL/min. The column temperature was ambient and carotenoids were detected in a UV/VIS detector at 474 nm. Standards of astaxanthin, p-Carotene, canthaxanthin, zeaxanthin, 9-cis-AX, 13-cis-AX were used to identify carotenoids in the sample. When required, the column was cleaned with 10 volumes each of hexane, methylene chloride, isopropanol, methylene chloride, and hexane:acetone (82:18, v/v). For water removal (when needed), the column was flushed with 60 mL of 2.5% of 2,2-dimethoxy propane, and 2.5% of glacial acetic in hexane. The column was stored in hexane or isopropanol.
Carbon Source
Glucose
[0353] The DNS method was used to measure the concentration of reducing sugars (Miller, 1959). The DNS solution consisted of (g/100 mL): DNS (1), NaOH (1.6), KOH (2.24), Na K Tartrate (30) to 100 mL of distilled water. The technique was adapted so as to be undertaken in microplates of 96-wells where 10 pL of each sample was placed into a 200 pL well of a PCR plate. Then 70 pL of water was added to each well. The blank used 80 pL of water. Next, 120 pL of the DNS solution was added to each well. This solution was centrifuged for 5 min at 4000 g and heated in a thermocycler for 5 min at 100 C. Finally, 170 pL was transferred into a 96-well plate to measure absorbance at 540 nm in a microplate reader. A linear growth curve of glucose (in a range of 0.1 to 10 g/L) was created and used to calculate the concentration of glucose in the sample in g/L.
Sucrose
[0354] Sucrose was measured using the DNS technique, as for glucose. However, the sucrose was firstly inverted using an acid treatment where 10 pL of the sample was treated with 2 pL of HCl 37% at 90 C. for 5 min. To neutralise the solution, 5 pL of NaOH 10 M was added. After the inversion, the technique was performed as for glucose. The concentration of sucrose was calculated using a linear curve in the linear range of 0.1 to 10 g/L.
Mutagenic and Screening Methods
Mutagenic Technique Using N-Methyl-N-Nitro-N-Nitrosoguanidine (NTG)
[0355] Cells growing at the mid-exponential phase were washed twice with citrate buffer 0.1 M at pH 5.5. The cells were then treated with NTG at 0.1 g/L (dissolved in citrate buffer) for 30 min. These treated cells were then washed twice with a phosphate buffer 0.1 M at pH 7. Before plating on YM agar plates, treated cells were incubated on YM media on a rotary incubator at 20 C. and 250 rpm for 3 h. The plated cells were incubated at 20 C. for seven days. Cells with an increased red-colour were selected and the NTG treatment repeated. This protocol was performed until any increasing concentration of the red colour was no longer observed.
Mutagenic Technique Using UV-Light
[0356] Cells growing at the mid-exponential phase were washed twice with a phosphate buffer 0.1 M at pH 7 and centrifuged at 4000 rpm for 5 min. Cells adjusted to an A.sub.600 of 0.3, and 5 mL were placed in a plate and treated with the UV-light source of a biosafety cabinet for 10 min.
Mutagenic Technique Using Ethyl Methyl Sulfonate (EMS)
[0357] Cells growing at the mid-exponential phase were washed twice with a phosphate buffer 0.1 M at pH 7. Cells were centrifuged at 4000 rpm for 5 min. Cells were adjusted to an A.sub.600 of 0.3, and 5 mL were resuspended in the same buffer containing 4% EMS and treated for 2 h. Finally, treated cells were washed twice with the phosphate buffer and subjected to further screening analyses.
Screening Methods with Selective Pressure
[0358] Cells treated with the different mutagenic agents were incubated for 3 h in YM media at 20 C. and plated YM agar plates supplemented with 1 mM -ionone (Bon et al., 1997), 75 pM diphenylamine (Chumpolkulwong et al., 1997), or 50 pM of antimycin A (Sigma Cat. No. A8674) (An et al., 1989). To perform screening with fluorescence activated cell sorting (FACS), treated cells were grown in a buffered YM media, stressed with 20 mM H.sub.2O.sub.2 after 1 day of incubation, supplemented with 20 g/L of sucrose after 3 days of incubation and allowed to grow for an additional 3 days.
[0359] Screening and selection of putatively superior strains using FACS was performed as described in Ukibe et al., 2008. Initially, the BD FACS Aria II flow cytometer, equipped with an ion laser emitting at 488 nm, was used to select putatively superior strains. Before analyses, cells were washed twice with a 10 mM potassium phosphate buffer (pH 7.4) and filtered through a 40 mm nylon mesh and placed into a 5 mL polystyrene 1275 mm tube (BD Cat. No. 352063). Florescence emissions were measured in two channels at wavelengths of 490-550 nm and 665-685 nm. In further screenings, the cells were screened in a BD FACS ARIA III Cell Sorter using a yellow-green laser excited to 561 nm and a blue laser excited to 488 nm. The forward scatter signal (FS), side scatter signal (SC), and fluorescence intensities were measured simultaneously. Fluorescence emission was measured at 670/14 nm and 530/30 and cells with the highest fluorescence were collected in YM sterile medium. Sorted cells were then plated in YM plates and incubated for 7 days at 20 C. In all strategies, colonies with an increased red colour were selected for further analyses.
High Throughput Screening
[0360] Selected colonies were cultivated in 24 deep well plates (Axygen Cat. No. AX-P-DW-10ML-24-C) with 3 mL of YM buffered culture media in each well. The plates were covered with breathable paper (Axygen Cat. No. AX-BF-400-S-1) to allow the exchange of gasses. The plates were incubated in a shaker incubator at 250 rpm and 20 C. for 6 days. The cells were stressed with 20 mM of H.sub.2O.sub.2 at day 1 of incubation and allowed to grow for an additional 2 days before being supplemented with 30 g/L of sucrose and allowed to grow for an additional 3 days.
Culture Media Optimization
[0361] Nutritional requirements were studied in three steps. First, single factor designs were used to test the effect of different nitrogen and carbon sources. A response surface was then used to optimise the significant media components in a screening factorial design. Finally, a feeding profile was designed in a fed-batch culture to maximise AX production.
Single Factor Design Experiments
[0362] The media composition to test nitrogen sources was made of (g/L): magnesium sulphate (1.5), monobasic potassium phosphate (1.5), and sucrose (20). Potassium hydrogen phthalate was used as a buffer (20 g/L). The pH was adjusted to 5.5 with NaOH 2 M. The nitrogen sources tested were (g/L): yeast extract (5), malt extract (5), bactopeptone (5), dried corn steep liquor (5), urea (2.14) and ammonium sulphate (4.71). The media to test different carbon sources was made of (g/L): ammonium sulphate (5), magnesium sulphate (1.5), monobasic potassium phosphate (1.5), yeast extract (3), dried corn steep liquor (5), and malt extract (3). Potassium hydrogen phthalate was used as a buffer (20 g/L). The carbon sources tested were sucrose, glucose, molasses, and glycerol.
Statistical Experimental Design and Surface Response
[0363] An initial screening test was conducted with seven components of the culture media using a factorial design 2.sup.k-p (k=factors=7; p=fractionation=4). The basal media to perform the design was made of (g/L): magnesium sulphate (1.5), calcium chloride (0.8), iron sulphate heptahydrate (0.019), and potassium hydrogen phthalate as a buffer (20). The media was supplemented with trace salts (mg/L): citric acid (15), ZnSO.sub.4.Math.7H.sub.2O (5); CuSO.sub.4.Math.5H.sub.2O (0.75); MnSO.sub.4 (0.60); H.sub.3BO.sub.3 (0.60); Na.sub.2MoO.sub.4-2H.sub.2O (0.60); KI (0.15), and vitamins (mg/L): vitamin B3 (Niacin) (3); vitamin B5 (Pantothenic acid) (4.5); vitamin B1 (Thiamine) (3); vitamin B6 (Pyridoxine) (0.3); vitamin B7 (Biotin) (0.18); p-aminobenzoic acid (1.8). The pH was adjusted to 5.5 with sodium hydroxide 2 M. The factors tested were bactopeptone (Low Level 1 g/L; High Level 3 g/L), malt extract (Low Level 1 g/L; High Level 3 g/L), yeast extract (Low Level 3 g/L; High Level 5 g/L), dried corn steep liquor (Low Level 2 g/L; High Level 5 g/L), potassium phosphate monobasic (KH.sub.2PO.sub.4) (Low Level 1 g/L; High Level 2 g/L), Sucrose (Low Level 20 g/L; High Level 30 g/L), or a vitamin cocktail (Low Level 1X; High Level 2X). Further optimization was performed using a Central Composite Design and Response Surface Methodology.
Model Development for Fed-Batch Design
[0364] The model was first developed as a batch culture and then extrapolated to a fed-batch system. The parameters of the batch model were obtained from fermentations on flask culture using 10, 15, and 25 g/L in an optimised culture media. The model was developed on the following assumptions: [0365] 1. Sucrose is the only limiting carbon source; [0366] 2. There is no nitrogen limitation; [0367] 3. The pH is known and controlled throughout the fermentation at pH=5.5.
Batch Model
[0368] The differential mass balance equations (1) to (6) describe the dynamics of AX production in batch fermentation as follows:
[0369] Eq. (1) represents the growth rate and Eq. (4) its specific rate (). Eq. (2) represents the consumption rate of sucrose and Eq. (5) its specific rate. Eq. (3) represents the carotenoid expression and Eq. (6) its specific production rate that considers growth associated and non-associated production.
Fed-Batch Model
[0370] The batch model was extrapolated to a fed-batch culture to design the feeding profile.
[0371] The fed-batch model is represented as equations (7) to (11) whereby a differential equation to represent volume (V) used to calculate the factor dilution (D) were added to the equations (1) to (3).
[0372] In equation (8), So represents sugar concentration in the feeding solution. Equations (12) and (13) were used to design an exponential feeding profile:
[0373] Where Xo and Vo represent the initial biomass and volume, respectively.
Reliability of the Model
[0374] The coefficient of determination (R.sup.2) was used to determine the reliability of the model. The R.sup.2 was calculated as follows:
Parameter Estimation of the Model
[0375] The model parameters were obtained from batch fermentations at different initial carbon sources. The package SBPDgui of the System Biology Toolbox 2 (SBTOOLBOX2) (Schmidt and Jirstrand, 2006) was used to determine the model parameters.
Instrumented Fermenters
[0376] Laboratory optimization of AX production in X. dendrorhous was performed in a 2 L Biostat A fermenter. The fermenter was configured with 2 six-blade Rushton impellers with a diameter of 5 cm, three baffles, one ring sparger, and ports for acid, base, antifoam, feeding solution, and sampling. The fermenters were equipped with probes and controllers of pH, dO.sub.2, temperature, and antifoam to measure and control these parameters, respectively. Optimal fermenter conditions were as follows: the fermenter was inoculated using a 10% inoculum culture at an A.sub.600 from 5 to 10 (cells growing at the mid-exponential phase). The pH was maintained at 5.5 using 12.5% of Ammonium Hydroxide or 2 M of sulphuric acid. The foam was controlled by adding Antifoam C (Sigma Cat. No. A8011). The temperature was controlled at 20 C. using a heater jacket or chiller. The dissolved oxygen was controlled at 70% of air saturation by using cascade changes in agitation (400-1200 rpm), air flow rate (0.4-5 VVM), or pure oxygen flow rate (0-0.5 VVM).
Culture Medium for Fed-Batch Fermentation
[0377] The following media was used for high cell densities in fed-batch fermentations (BYM). The BYM media was made of (g/L): yeast extract (5), malt extract (5), monobasic potassium phosphate (5), magnesium sulphate (1.5), ammonium sulphate (4), FeSO.sub.4.Math.7H.sub.2O (0.10), CaCl.sub.2) (0.4), sucrose (20). The media was supplemented with trace salts (mg/L): citric acid (225); ZnSO.sub.4.Math.7H.sub.2O (75); CuSO.sub.4.Math.5H.sub.2O (11.25); MnSO.sub.4 (9); H.sub.3BO.sub.3 (9); Na.sub.2MoO.sub.4.Math.2H.sub.2O (9); KI (2.25), and vitamins (mg/L): vitamin B3 (Niacin) (18.99); vitamin B5 (Pantothenic acid) (28.48); vitamin B1 (Thiamine) (18.99); vitamin B6 (Pyridoxine) (1.89); vitamin B7 (Biotin) (1.13); p-aminobenzoic acid (11.39).
Feeding Solution and Feeding Strategy
[0378] The BYM 2X at 500 g/L of sucrose was used for the growth phase (0-3.5 days) of the fed-batch culture. The BYM 2X was made of (g/L): yeast extract (10), malt extract (10), monobasic potassium phosphate (10), FeSO.sub.4.Math.7H.sub.2O (0.20), CaCl.sub.2) (0.8), and sucrose (500). Carbon source and culture medium components were sterilised separately at 121 C. for 15 min. The media was supplemented with trace salts (mg/L): citric acid (345); ZnSO.sub.4.Math.7H.sub.2O (5); CuSO.sub.4.Math.5H.sub.2O (17.25); MnSO.sub.4 (13.8); H.sub.3BO.sub.3 (13.8); Na.sub.2MoO.sub.4.Math.2H.sub.2O (13.8); KI (3.45), and vitamins (mg/L): vitamin B3 (Niacin) (30); vitamin B5 (Pantothenic acid) (45); vitamin B1 (Thiamine) (30); vitamin B6 (Pyridoxine) (3); vitamin B7 (Biotin) (1.8); p-aminobenzoic acid (18). The pH was adjusted to 5.5 with sodium hydroxide 2 M. From the 3.5 to 7 days of cultivation, the feeding solution consisted of sucrose at 800 g/L. The feeding strategy was designed using the kinetic model for a fed-batch culture. The feeding profile consisted of batchfed-batch (exponential feed rate at 0.08 h.sup.1)fed-batch (constant feeding rate at 4.16 mL/h)batch.
Genome Sequencing and Bioinformatics Analyses
DNA-Sequencing
[0379] DNA was extracted using the YeaStar Genomic DNA Kit (Zymoresearch Cat. No. D2002) and quantified using the Nanodrop 1000 (Thermo Scientific) and Qubit dsDNA BR assay kit (Life Technologies Cat. No. Q32850). The DNA quality was determined by running a 1% agarose gel with a DNA gel stain SYBR safe (Life Technologies Cat. No. S33102). The gel was visualised using a ChemiDoc MP system (Bio-Rad). The Illumina platform was used to sequence the genomes of nine strains (wild-type X. dendrorhous CBS 6938 and eight mutant strains). Sequencing was performed using MiSeq V3 600 Cycle 300 PE (Illumina Cat. No. MS-102-3003). Libraries were prepared using the Illumina Nextera XT library preparation kit (Illumina Cat. No. FC-121-2003).
Bioinformatics
[0380] Sequenced genomes were analysed using the following bioinformatics tools. Firstly, FastQC was used to evaluate the quality of the Illumina reads (Andrews, 2010). Trimmomatic was then used to remove poor quality reads (Bolger et al., 2014). Assembly of reads was performed using a reference genome. For this step, Bowtie2 was used to align the reads against the publicly available genome X. dendrorhous CBS 6938 (accession ids in the European Nucleotide Archive: LN483084-LN483350) (Langmead and Salzberg, 2012; Sharma et al., 2015). Then, the Velvet genome assembly algorithm was used to assemble the reads (Zerbino, 2010). To objectively determine genome similarity, the genome-to-genome distance calculator (GGDC 2.0) was used to calculate the genome distance between two genomes (Auch et al., 2010). The TMHMM server 2.0 was used to predict transmembrane helix proteins (Krogh et al., 2001). Variant analyses was performed with GATK by using the recommended best practices for a non-model organism (Auwera et al., 2013; Kryvokhyzha, 2016). Here, BWA-MEM was used to align the Illumina reads against the published genome X. dendrorhous CBS 6938 (Li and Durbin, 2010; Sharma et al., 2015). In further filter analyses, the detected variants, namely SNPs and INDELs, were filtered out if the number of reads harbouring the mutation were below the total reads. BCFtools and Samtools were used to compare and manipulate the VCF files resulting from the variant analyses (Li et al., 2009). SnpEff was used to annotate the variants and SnpSift to filter them (Cingolani et al., 2012). IGV viewer was used for visualization (Thorvaldsdottir et al., 2013).
Results
Mutant Strains with Enhanced Carotenoid Production
[0381] The wild-type X. dendrorhous CBS 6938 was submitted to recursive NTG mutagenic cycles and screening in YM plates until a visible plateau of pink-colour improvement was achieved. After four mutagenic cycles, a pool of the best strains was selected to perform further mutagenic cycles using either UV-light, EMS, or NTG, with different screening methods including fluorescence activated cell sorting, antimycin, (3-ionone, or diphenylamine (
Single Factor Design Experiments
[0382] Different organic and inorganic nitrogen sources were evaluated for growth and production of AX by mutant X. dendrorhous strain MYM0 (Table 2). Single factor statistical analyses gave significant results (p<0.05) for the response variables of growth (A.sub.600) and production (total carotenoids and intracellular carotenoid content (Ypx)). Here, except for malt extract, all nitrogen sources tested had similar growth performances (A.sub.600) with growth from 18.60 to 21.76. Malt extract had the highest intracellular carotenoid content (Ypx) with 3.94, 1.85, 1.09, 1.19, and 1.40-fold improvements compared to urea, ammonium sulphate, yeast extract, bactopeptone, and dried corn steep liquor, respectively. The best performing nitrogen sources in terms of carotenoid production were yeast extract and bactopeptone, followed by ammonium sulphate, dried corn steep liquor, malt extract, and urea. Table 2 shows that urea led to the lowest specific carotenoid production, suggesting that it may be a sub-optimal nitrogen source for carotenoid production in this strain. The carbon sources molasses, glucose, glycerol, and sucrose were also tested for growth and carotenoid production. MYM0 was able to grow and produce carotenoids in all carbon sources tested (Table 3). Here, the observed growth (A.sub.600) was from 19.79 to 27.89, specific production from 3132 g/gDCW to 4778 g/gDCW, and carotenoid production from 36,047 to 53,395 g/L. Except for molasses, all carbon sources had a similar growth performance. Glycerol and molasses led to similar levels of catotenoid production, with an improvement of 1.52-fold compared to glucose and sucrose. Of note is that the lag phase for growing on glycerol was extended for three days compared to six hours for the other carbon sources.
Factorial Design and Surface Response
[0383] Initial screening was conducted with seven components of the culture media by using a factorial design of 2.sup.k-p (k=7; p=4). Tables 5, 6, and 7 show results for the analyses of variance for growth, carotenoid production, and specific yield, respectively. The significant factors were bactopeptone, malt extract, yeast extract, sucrose, and dried corn steep liquor (p<0.05). These factors were further used to perform a Central Composite Design (for the experiments) and Response Surface Methodology for identifying the optimal levels). The effects of malt extract, yeast extract, Sucrose, and dried corn steep liquor were studied at five experimental levels (1.6818, 1, 0, 1, 1.6818) for growth and production. Sucrose, malt extract, and yeast extract stimulated production. In contrast, dried corn steep liquor was observed to be detrimental for carotenoid production. As a result, this media component was removed from further experiments. Experimental results were fitted to a predictive quadratic model and identify the conditions for maximal carotenoid production. Table 8 demonstrates the model was able to predict production with a Coefficient of Variance within 5%.
Fed-Batch Fermentation
[0384] After culture media optimization, production was scaled-up to instrumented fermenters using a non-structure model. This model was validated using kinetic data in a batch mode at 10 g/L and 25 g/L of initial sucrose concentration (
Bioinformatics Analyses
[0385] From the strains screened for production (
Variant Analyses
[0386] The genome sequence and annotation of X. dendrorhous CBS 6938 was used as a reference to call and annotate the variants (Sharma et al., 2015). After filtering the variants using the criteria detailed hereinabove, there were 983, 1009, 1037, 994, 1015, 977, 1067, and 1091 SNPs and 52, 64, 47, 68, 76, 66, 68, and 61 INDELs detected for the strains MYM6_Y2, MYM0_Y11, MYM44_Y14, MB18_Y15, MAMY3_Y16, MB24_Y17, MYM92_Y4, and MAMY6_Y12, respectively. Next, any mutations detected in the re-sequenced X. dendrorhous CBS6938 compared to the published sequence were removed from the newly sequenced mutant strains. Mutations present across all strains were extracted and used for variant analyses (
Conserved Variants
[0387] Table 13 shows the types of mutations detected across the eight sequence mutant strains, and the genomic details location of the mutation in the chromosome, gene name, protein, gene ID, type of mutation, gene length, protein length, effect, and amino acid change. There were 144 non-synonymous missense mutations in coding regions found across all of the newly sequenced mutant strains. From these mutations, 27 in proteins annotated as hypothetical proteins while the remaining were in more specifically annotated proteins.
[0388] Of the mutations in specifically annotated proteins, several were found in subunits of complex proteins. Four SNPs were found in subunits of the gene encoding cytochrome c oxidase: subunit 1, subunit 2, subunit 3. In addition to this cytochrome-related protein, the cytochrome b2 gene encoding protein was also mutated. Five SNPs were found in subunits of the gene encoding to the NADH dehydrogenase protein. Among other mutations in subunits, the ATP synthase subunit 6 gene encoding protein was also mutated. In terms of mutations in genes encoding proteins related to transporters, a small molecule transporter, an ABC transporter, and a sucrose transporter were mutated. Five SNPs in Zn-finger proteins encoding genes were also mutated including C4-type Zn-finger, an uncharacterised MYND Zn-finger, Zn(2)-C6 fungal-type DNA-binding domain gene encoding protein, Zinc finger RING-type, and the related to C2H2 zinc finger protein FLBC. Fatty acid related gene encoding proteins were mutated including the delta 9 fatty acid desaturase, and the acyl-CoA oxidase. From mutations of the TCA cycle, the gene encoding to fumarate reductase was mutated. Mutations were also found in the pantothenate kinase (PanK), the calcium-transporting ATPase, the Snf2 family amino-terminal protein, the 1-aminocyclopropane-1-carboxylate synthase, the cysteine proteinase and the ferredoxin/adrenodoxin reductase encoding genes.
[0389] Notably, high impact mutations included two SNPs leading to premature stop codons in a WD40 repeat-containing protein and a G protein-coupled receptor, rhodopsin-like, respectively. Additionally, a loss of start codon mutation was detected in one protein annotated as a hypothetical protein. Six mutations within 100 bp upstream of a gene were found including cytochrome b, inositol polyphosphate multikinase, components of the ARGR transcription regulatory complex, mRNA (guanine-n7-)-methyltransferase, and glucosyltransferase-Alg8p; two of these types of effect mutations were annotated as hypothetical proteins. Six mutations with the effect Splice Donor and Intron Variant were found. This type of mutation causes the loss of a splicing signal that defines the 3-end of an exon, the consequence being that the whole intron could be retained as the splicing machinery is unable to recognise the splice donor site (Jian et al., 2013). The mutations found with this effect included the predicted E3 ubiquitin ligase, acid phosphatase, predicted Zn-finger protein, palp-domain-containing protein, Zn(2)-C6 fungal-type DNA-binding domain, and uncharacterised conserved protein. Four mutations were found with the effect missense and splice region variant including mercaptopyruvate sulfurtransferase/thiosulfate sulfurtransferase, ATP-NAD kinase, snf2-family ATP dependent chromatin remodelling factor snf21 with G3713A, and arsenical pump-driving ATPase.
[0390] Overall, 25 mutations conserved across the sequenced strains were identified as of particular interest, as set out in Table 14.
DISCUSSION
Strain Improvement
[0391] In this example, mutagenesis was applied using NTG combined with EMS and UV-light, and incorporated screening methods with selective pressure or cell sorting in the last mutagenic cycle, with the intention of producing mutagenized X. dendrorhous capable of enhanced AX production. This methodology resulted in strains capable of greater than 15-fold AX production as compared to the wild-type strain (e.g.,
[0392] The use of antimycin, diphenylamine, or -ionone in our screening methods appeared to assist with the selection of superior strains. Antimycin inhibits the cytochrome P450 enzyme responsible for providing electrons during the oxygenation of the AX molecule by the AX synthase (Bon et al., 1997; Ojima et al., 2006), diphenylamine inhibits the phytoene desaturase enzyme leading to an accumulation of the colourless carotenoid phytoene (Chumpolkulwong et al., 1997), and, p-ionone competes with the p-carotene molecule during its oxygenation by the AX synthase to produce AX (Lewis et al., 1990).
[0393] Cell sorting (FACS) was also used as a screening method to select superior strains. FACS used fluorescence properties of the AX molecule to select strains with an improved ability to produce AX. Additionally, as cells screened with FACS were stressed with H.sub.2O.sub.2, cells were selected for increased tolerance to oxidative stresses which is associated with an improved ability to produce AX (Schroeder and Johnson, 1995).
Culture Media Optimization and Fed-Batch Fermentation
[0394] Classical random mutagenesis produces unique strains with specific phenotypic traits making it challenging to directly extrapolate culture media optimization results from other studies. Therefore, one of the selected strains, MYM0, was subjected to a culture media optimization process.
[0395] Different nitrogen sources were tested to grow X. dendrorhous cells including urea, ammonium sulphate, yeast extract (YE), malt extract (ME), bactopeptone (BP), and dried corn steep liquor (DCSL) (see Table 2). While urea has been reported to be a low-cost and promising nitrogen source to grow and produce AX in X. dendrorhous (An et al., 2001; Fontana et al., 1996), this example identified that urea inhibited carotenogenesis in our selected strain (Table 2). Ammonium sulphate is another low-cost nitrogen source used to grow X. dendrorhous cells (Flores-Cotera et al., 2001; Ni et al., 2007). The example provided here is consistent with these earlier studies, with ammonium sulphate resulting in the highest growth. YE, ME, and BP are part of the YM media used as a routine to grow X. dendrorhous cells. The evaluation of these media components as a sole nitrogen source confirmed its effectiveness to grow and produce AX. Of note is that ME produced the highest carotenoid content in our selected strain suggesting the importance of this media component. BP delivered improved growth and carotenoid production but its high cost that means this nitrogen source is sometimes replaced by other low-cost sources such as urea or ammonium sulphate (Ni et al., 2007).
[0396] Different carbon sources were also tested to grow and produce AX in the selected strain. Table 3 confirms that the selected strains grew in several carbon sources including glucose, sucrose, glycerol, and molasses and can be used to produce high cell densities. The best performing nitrogen and carbon sources were then optimised in a surface response experiment to determine optimal levels to maximise growth and AX production.
[0397] X. dendrorhous is a Crabtree positive yeast (high level of sugars produce fermentative products during aerobic fermentations) which limits the application of batch fermentations at a high concentration of carbon source (Reynders et al., 1997). To overcome this limitation, the optimised media and a nonstructure model were used to design the feeding profile for the fed-batch culture. Notably, after seven days of fermentation, the AX production of X. dendrorhous MYM0 increased 50-fold compared with the wild-type strain.
[0398] The final biomass achieved was above 100 gDCW/L and the carotenoid content was around 1 g/L (
[0399] Luna-Flores et al., 2010 used kinetic models to design the feeding profile of a fed-batch culture but the media used in that study was not optimised, rendering 3-fold less growth than in the example presented here. The superiority of our approach highlights the significance of incorporating culture media optimisation in selected strains before using them in fed-batch fermentations.
[0400] While glycerol has been reported to be an effective carbon source to stimulate AX production in X. dendrorhous (Silva et al., 2012), and despite glycerol supported growth and production being similar to other carbon sources in a flask fermentation (Table 3), when tested in a fed-batch culture during the maturation phase (after day 3.5 of culture), glycerol in fact accumulated suggesting that it is a poor carbon source for the tested strain. This poor performance when using glycerol in fed-batch fermentations may well be associated with the long adaptation phase prior to assimilation of glycerol (Table 3).
[0401] Molasses has previously been tested in X. dendrorhous with two to three times more AX obtained than when using glucose or a synthetic blend of sugars that constitute molasses (Haard, 1988). Our results are consistent with this previous finding with molasses increasing AX production 1.52-fold compared with glucose or sucrose (Table 3) in the tested strain. The stimulation of AX production by molasses suggests it is a promising carbon source to maximise carotenoid production for strains obtained by this approach.
Genome and Variant Analyses
[0402] The genome assembly and filter method (remove contigs below 300 bp and depth below 10X) applied to the selected strains generated genome assembly sizes ranging from 18.55 Mb to 19.11 Mb (Table 4). The genome sizes without filtering the contigs using the mentioned criteria of size and depth resulted in assembly sizes of 19.140.15 for all the genomes.
[0403] The observed genome sizes were similar to the 19.50 Mb genome of the previously sequenced wild-type X. dendrorhous CBS 6938 strain (Sharma et al., 2015). Similarly, the genome size of the re-sequenced X. dendrorhous CBS 6938 was 19.20 Mb. The GC contents in the new strains and re-sequenced wild-type strain were around 48% which were similar to the 47.3% GC content of the publicly available wild-type strain (Table 4) (Sharma et al., 2015). In previous studies with related strains, X. dendrorhous CBS 7918 yielded a 18.7 Mb genome and 47.2% GC content, and X. dendrorhous CRUB 1149 an 18.9 Mb genome and 47.1% GC content (Libkind et al., 2011).
[0404] Genome to genome distance was calculated to objectively calculate the similarity between our selected strains and the wild-type strains (Auch et al., 2010). The genome distance calculated was 0.01 for the re-sequenced X. dendrorhous CBS 6938 and 0.02 for the selected strains (the closer to 0 the more similar the strains in comparison) suggesting that the wild-type strains are more similar between themselves than with our selected strains. This genome comparison confirmed the genome similarity among the X. dendrorhous strains used in this example and those with a genome sequence publicly available.
Genomic Mutations Associated with AX Biosynthesis in X. Dendrorhous
[0405] X. dendrorhous uses the precursor isopentenyl pyrophosphate (IPP) for AX biosynthesis, which is generated via the mevalonate (MVA) pathway, starting from acetyl-CoA. Here, a mutation was identified in the pantothenate kinase encoding gene, which is required in the first reaction of the conenzyme A (CoA) biosynthetic pathway (Table 14). Pantothenate kinase phosphorylates panthothenate to form phophopanthothenate at the expense of a molecule of ATP. This reaction is a limiting step in the biosynthesis of CoA, required by the MVA pathway in the form of acetyl-CoA.
[0406] The MVA pathway uses five enzymes to produce IPP, in which 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is a critical regulator and the enzyme that catalyses the production of MVA (Goldstein and Brown, 1990). Here, a mutation was identified in the gene encoding to the HMGR enzyme (see Table 14). HMGR overexpression has been associated with an improvement of AX in X. dendrorhous indicating that the mutation found in the HMGR gene may influence the AX production increase in our selected strains. For example, the addition of ethanol to cultures of the mutant strains X. dendrorhous P-5-6 and Dp-41 overexpressed 3-fold the HMGR gene which was associated with the increase of AX production on those mutated strains (Gu et al., 1997). Similarly, the overexpression of three MVA synthetic pathway genes, namely acetoacetyl-CoA thiolase, HMG-CoA synthase, and HMGR in X. dendrorhous increased AX production 2.1 fold (Hara et al., 2014).
[0407] Following the IPP synthesis through the MVA pathway, eight IPP molecules are then condensed through prenyltransferases in which IPP isomerase catalyses the isomerization of IPP to dimethylallyl-pyrophosphate (DMAPP), and then both molecules joined, generating geranyl pyrophosphate (GPP) (Kajiwara et al., 1997). The addition of a second molecule of IPP to GPP gives the precursor C-15 sesquiterpene, farnesyl pyrophosphate (FPP), which is converted into geranylgeranyl-pyrophosphate (GGPP) by a further addition of IPP by the GGPP synthase (see Table 14) (Niklitschek et al., 2008). In this example, the new strains presented a mutation in the GGPP synthase encoding gene, which in abundance has been associated with a remarkable carotenoid production in ripening fruit (Sandmann, 1994). Because GGPPs are the building blocks of the carotenogenesis pathway, the mutation in the GGPP synthase gene might positively influence the synthesis of GGPPs and thus the carotenoid production in our selected strains.
Mutations Associated with Carbon Source and Nutrient Assimilation
[0408] This example used sucrose as a carbon source in all screening and selection experiments and efficiently produced high cell densities in a fed-batch culture (
[0409] A mutation identified in a gene encoding a G protein-coupled receptor, rhodopsin-like protein (GPCR) had the effect Stop Gained. GPCR proteins comprise the largest class of membrane proteins in eukaryote genomes with a common denominator of seven-transmembrane domains. Yeast has three different GPCR proteins for pheromone and sugar sensing (Lengger and Jensen, 2020). Glycerol was a carbon source tested in the selected strains to grow and produce AX (Table 3). For glycerol, the lag phase lasted three days before the culture started to grow. In a fed-batch culture, glycerol failed as it accumulated during its feeding. Potentially, this GPCR mutation is negatively influencing the ability of the selected strain to grow under glycerol as a carbon source. Further analyses in the GPCR mutation using the TMHMM server 2.0 revealed that the transmembrane helices of the GPCR protein were not affected as these were found in the first 200 amino acid sequencesthe stop gained was at the position 395/523 (see Table 14 and
[0410] Five mutated genes encoding Zn-finger-type proteins (Table 14), comprising small a protein structural motif characterised by the coordination of one or more zinc ions in order to stabilise the fold, were also identified. These protein types interact with RNA, DNA, or proteins altering their binding specificity for a particular protein. Zn-finger proteins have been associated with the regulation of nitrogen assimilation in Neurospora crassa or Aspergillus nidulans (Fu and Marzluf, 1990), so it is possible that mutations of Zn-finger genes in the selected strain of P. rhodozyma resulted in superior use of ammonium sulphate as compared to urea as a nitrogen source (Table 2).
Mutations Associated with Oxidative Phosphorylation and Stress
[0411] Schroeder et. al., 1995 indicated that AX plays an important role against oxidative stress in X. dendrorhous (Schroeder and Johnson, 1995). This oxidative stress link with AX production is also supported by the evidence that AX production in X. dendrorhous is mainly associated with respiratory or aerobic fermentations rather than anaerobic ones (Luna-Flores et al., 2010). ROS tends to be generated during the respiration phase because of electron overflow in the respiratory chain caused by an imbalance of electron transfer during reduction of the ubiquinone pool and electron transfer occurring downstream in the respiratory chain. AX can quench ROS in a manner analogous to superoxide dismutase in which harmful oxygen molecules are break down and eliminated (Schroeder and Johnson, 1993).
[0412] ROS are produced via the respiratory electron chain and, in this example, mutations in subunits of the electron transport chain components affecting the complexes I, III, IV, and V (Table 14) were identified. Of these mutations, four were found in subunits of the cytochrome c oxidase (CoC) protein. This CoC protein is responsible for carrying the electrons from complex III to complex IV in the electron transport chain, the last step in the electron transport chain. In fact, this complex is inhibited by antimycin or potassium cyanide (KCN), a compound used in our studies as a screening method.
[0413] Evidence suggesting that X. dendrorhous shifted from KCN-sensitive to KCN-insensitive growth in later growth phases (carotenoid production phases) (Schroeder and Johnson, 1993) supports the importance of alternative pathways of oxygen utilization during AX biosynthesis. Another report suggests that mutant strains sensitive to antimycin, can create an imbalance in the flow of electrons during the electron transport chain, increasing the amount of ROS and so improving AX production (An et al., 1989). This overflow of electrons can also increase AX production by the action of AX synthase, an enzyme that belongs to the P450 family enzyme and requires an electron donor (P450 reductase or cytochrome b), to incorporate the oxygen functional groups to the molecule of p-carotene.
[0414] In this example, a mutation of a ferredoxin/adrenodoxin reductase encoding gene (Table 14) was also observed. Adrenodoxin is a cAMP-regulated ferredoxin that transports electrons from NADPH-dependent adrenodoxin reductase to P450 family enzymes (Grinberg et al., 2000). The electron donor capability of ferredoxin/adrenodoxin reductase that suggests a potential role as an electron donor required by AX synthase. Other mutations associated with the electron transport chain included a mutation in the cytochrome b, cytochrome b2 and ATP synthase encoding genes and five mutations in subunits of the NADH dehydrogenase protein (Table 14). These mutations are potentially associated with the improved AX production in the selected strains due to the abundance of oxidative phosphorylation enzymes such as NADH dehydrogenase and ATP synthase, found when X. dendrorhous cells were growing on succinate as a carbon source, and where production of AX was around 2-fold more than when grown on glucose (Martinez-Moya et al., 2015).
[0415] Another mutation potentially associated with increased AX production in the selected strains is in an acyl-CoA oxidase encoding gene (Table 14). This enzyme is associated with the fatty acid metabolism in a reaction involving the oxidation of acyl-CoA to tans-2,3-dehydroacyl-CoA and the reactive oxygen species H.sub.2O.sub.2, which can trigger an increase of AX production to protect the cells from an oxidative stress (Liu and Wu, 2006).
[0416] Another mutation associated with lipid metabolism was observed in a delta 9 fatty acid desaturase, which is reported to have preferences for substrates of C18:1 and C16:1 converting to C18:2 and C16:2 fatty acids (L. Zhang et al., 2020). Notably, the most abundant fatty acids in the X. dendrorhous pathway are linoleate (C18:2), stearic acid (18:0), oleic acid (C18:1), palmitic acid (C16:1), and hexadecanoic acid (16:2) (Sharma et al., 2015). The proportion of fatty acid and its influence to produce AX (Miao et al., 2011) suggests that the mutation in the delta 9 fatty acid desaturase encoding gene may stimulated AX production in our selected strains of X. dendrorhous.
[0417] It is further notable that, in this example, antimycin, -ionone, diphenylamine, or the stressor H.sub.2O.sub.2 were used in the screening methods to select superior strains of X. dendrorhous, which potentially increased selection for strains with the mutations in the electron transport chain to enhance AX production.
Example 2: Metabolomic and Transcriptomic Analysis of a High Astaxanthin Producer Strain of Xanthophyllomyces dendrorhous
[0418] In this example, one of the X. dendrorhous mutant strains developed as per Example 1, and the wild-type as a control, were cultured in chemically defined media and instrumented fermenters, and differential kinetic, metabolomics, and transcriptomics data were obtained. The results obtained in this example suggest that carotenoid production primarily occurred during growth phase.
[0419] During the growth phase, the mutant strain showed positive regulation of central carbon metabolism metabolites associated with glycolysis, the pentose phosphate pathway, the TCA cycle, and amino acid and fatty acid biosynthesis. In the stationary phase, amino acids associated with the TCA cycle increased, but most of the fatty acids and central carbon metabolism metabolites decreased. TCA cycle metabolites such as succinate, fumarate, and a-ketoglutarate were abundant during both growth and stationary phases.
[0420] The overall observed metabolic changes in the central carbon metabolism and abundance of TCA cycle metabolites suggest an enhancement in the electron respiratory chain in the mutant, and in the provision of the electrons required for the AX synthesis by the AX synthase, may be primarily responsible for enhanced AX production. Transcriptomic data correlated with the metabolic data and found a positive regulation of genes associated with the electron respiratory chain.
Materials and Methods
Strains, Media, and Growth Conditions
[0421] The wild-type strain of X. dendrorhous CBS 6938 and the mutant strain X. dendrorhous MYM0, each as described in Example 1, were used in this example. In this example X. dendrorhous MYM0 is hereinafter referred to as X. dendrorhous BPAX-A1. Storage of the strains was as described in Example 1. Chemically defined media for inoculum and fermenters contained (in g/L): glucose (20), (NH.sub.4)2SO.sub.4 (6), KH.sub.2PO.sub.4 (2), FeSO.sub.4.Math.7H.sub.2O (0.019), MgSO.sub.4.Math.7H.sub.2O (0.88), and CaCl-2H.sub.2O (0.2). Potassium hydrogen phthalate 20 was used as a buffer when growing in flasks. The pH was adjusted to 5.5 with NaOH 2M. The media was supplemented with trace salts (mg/L): ZnSO.sub.4.Math.7H.sub.2O (5.01), CuSO.sub.4.Math.5H.sub.2O (0.75), MnSO.sub.4 (0.48), H.sub.3BO.sub.3 (0.6), Na.sub.2MoO.sub.4.Math.2H.sub.2O (0.6), and KI (0.15) and vitamins (mg/L): myo-inositol (60), vitamin B3 (niacin) (3), vitamin B5 (pantothenic Acid) (3), vitamin B1 (thiamine) (3), vitamin B6 (pyridoxine) (3), vitamin B7 (biotin) (0.048), and p-aminobenzoic acid (1.8).
Analytical Techniques
Optical Density (A600)
[0422] OD was measured as for Example 1.
Dried Cell Weight
[0423] Dried cell weight was measured as for Example 1.
Total Carotenoids
[0424] Total carotenoids were assessed as for Example 1.
Hplc Analyses for Astaxanthin and Other Carotenoids
[0425] HPLC analyses for astaxanthin and other carotenoids were performed as for Example 1.
Hplc Analyses for Sugars and Organic Acids
[0426] Supernatants for sugar and organic acid analyses was obtained by centrifugation of 1 mL of fermentation sample at 15,000 rpm for 5 min. Organic acids and carbohydrates were quantified by ion exchange chromatography using an Agilent 1200 HPLC system and an Agilent Hiplex H column (3007.7 mm, PL1170-6830) with a guard column (PL Hi-Plex H 507.7 mm, PL1170-1830). Sugars were monitored using a refractive index detector (Agilent RID, G1362A) set on positive polarity and optical unit temperature of 35 C. while organic acids were monitored at 210 nm (Agilent MWD, G1365B). 30 gL of each sample was injected onto the column using an auto-sampler (Agilent HiP-ALS, G1367B) and the column temperature was kept at 40 C. using a thermostatted Column compartment (Agilent TCC, G1316A). Analytes were eluted isocratically with 5 mM H2SO4 at 0.4 mL/min for 40 min. Chromatograms were integrated using Chromeleon 7.2 software.
Intracellular Metabolite Extraction and Analyses
[0427] The following methods for quenching, extraction, and analyses were adapted from (Canelas et al., 2008, 2009; Martinez-Moya et al., 2015; Luna-Flores et al., 2018; Pan et al., 2020). Cells were quenched in cold methanol 60% and placed in a bath of ethanol/dry-ice. Cells were then centrifuged at 4,500 rpm for 5 min at 20 C. and pellet was washed with cold 60% methanol before to snap-freeze in liquid nitrogen. Cell pellets were kept at 80 C. until further use. The pellet was then dissolved in a mixture 1:1 of chloroform and methanol 50% and submitted to five cycles of 5 min of bead beating using acid washed glass beads (Sig. Cat. No. G1152-100G) and a tissue lyser (Qiagen TissueLyser II); the tubes were cooled down on ice for 5 min before start each cycle.
[0428] To separate polar and non-polar metabolites, the disrupted cells were centrifuged at 15,000 rpm for 15 min in which polar metabolites were in the top layer (methanol 50%) and non-polar metabolites were in the bottom layer (chloroform). The top layer was collected, freeze dried, and the pellet obtained was finally re-suspended in 2% acetonitrile. 5 uM of AZT, 3 ppm of 13-C valine, and 3 ppm of 13-C sorbitol were used as internal standards. LCMS was used to analyse central carbon metabolism using the method described in (Luna-Flores et al., 2018). Briefly, analyses were performed using a Dionex Ultimate 3000 HPLC system coupled to an ABSciex 4000 QTRAP mass spectrometer. Liquid chromatography was performed using a 50 min gradient with 0.3 mL/min flowrate, on a Phenomenex Gemini-NX C18 column (1502 mm, 3 gm, 110 A), with a guard column (SecurityGuard Gemini-NX C18, 42 mm), and column temperature of 55 C. The mobile phases used were: 7.5 mM aqueous tributylamine (Sigma-Aldrich) with pH adjusted to 4.95 (+0.05) using acetic acid (Labscan) for Solvent A, and acetonitrile (Merck) for Solvent B. Samples were kept at 4 C. in the autosampler and 10 gL of various dilutions of samples were injected for analyses. The HPLC was controlled by Chromeleon 6.80 software (Dionex). Mass spectrometry was achieved using a scheduled multiple reaction monitoring (sMRM) method on the negative ionisation mode. Collected data were processed using MultiQuant 2.1 (AB Sciex). The amino acids profile was obtained using the protocol described in (Chen et al., 2020). In brief, Shimadzu LCMS 8050 was used for amino acid analyses. This instrument was equipped with three quadrupoles for mass analysers and collision. Liquid chromatography was performed by injecting 1 uL of sample to a F5 column (Sigma) and eluted in a 25 min gradient using as mobile phase acetonitrile with 0.1% of formic acid at 0.25 mL/min. Oven was set to 40 C. Electrospray ionization was used to ionise the sample. Mass spectrometry was achieved using a scheduled multiple reaction monitoring (sMRM) method on the positive ionisation mode. Amino acid mix was used as standard for identification and quantification (Sig. Cat. No. A9906-1ML). Skyline daily was used to analyse amino acids detected in LC-MS (Adams et al., 2020). The fatty acid profile of yeast biomass was determined using the following procedure. A portion of dried yeast biomass (50 mg) was mixed with 2 mL solvents containing methanol/hydrochloric acid/chloroform (10:1:1, v/v/v). The mixture was heated at 90 C. for 1 h in a sealed glass tube to convert microbial oils to fatty acid methyl esters (FAMEs). Then the mixture was treated through mixing with 0.9% NaCl solution (1 mL). Afterwards, FAMEs were extracted through addition of 0.5 mL hexane, followed by centrifugation. Then, the supernatant hexane phase containing FAMEs were analyzed by an Agilent 6890 Series Gas Chromatography system equipped with a HP 5973 mass spectrometer detector and a HP-5MS capillary column (Agilent J&W 30 m0.25 mm0.25 [im). 1 [J.L of the sample was injected with a split ratio of 10:1. The injection port temperature was 230 C. Initial column temperature was 90 C. and held for 1 min, followed by increasing the column temperature at a rate of 15 C./min until 180 C., 5 C./min to 220 C., 10 C./min until 250 C. and held for 10 min. FAME Mix (Supelco 37 Component, Sigma-Aldrich) was used as standard.
Rna Extraction, Sequencing, and Analyses
[0429] Cells sampled at Phase III were used for RNA extraction and analysis. For this, cells (50 ODs) were quenched in cold methanol 60% and placed in a bath of ethanol/dry-ice. The cells were then centrifuged at 4,500 rpm for 5 min at 20 C. and the pellet was snap-frozen in liquid nitrogen and finally storage at 80 C. until further use. ZymoBiomics DNA/RNA Miniprep Kit (Zymo Research Cat. No. R2002) was used for RNA extraction. For this, the pellets were first submitted to a cryogenic grinding step using a mortar, pestle and liquid nitrogen. To ensure extraction, using indications of the kit, the grinded pellet was submitted to three cycles of five minutes of bead beating using a Qiagen Tissue Lyser II. This grinded extract was then used for RNA extraction following the indications of the kit. Extracted RNA was quantified using a NanoDrop and Qubit 4.0. The library was prepared using the Illumina Stranded mRNA prep kit. The quality of the RNA and library were evaluated by a Fragment Analyser 5200. Finally, the samples were sequenced using the Illumina platform 100 bp Pair End using NovaSeq 6000 and a SP PE100 flow cell. Quality of the reads was evaluated using FASTQC (Andrews, 2010) and Trimmomatic (Bolger et al., 2014) was used to remove bad quality reads. Then, Tophat, Cufflinks, and CuffDiff were used to align the RNA-seq reads against the reference genome X. dendrorhous CBS6938 (Sharma et al., 2015), normalize and annotate the transcripts, and evaluate the differential expression, respectively (Trapnell et al., 2012). The cutoff for significant differentially expressed genes was q<0.05.
Statistical Analyses of Intracellular Metabolomics
[0430] Metabolomics data were normalized and analysed for statistical significance (De Livera et al., 2012). Principal component analyses were used to profile all metabolites (Mendez et al., 2019).
Instrumented Fermenters
[0431] Instrumented fermenters were performed in a 1 L New Brunswick BioFlo/CelliGen 115. The fermenter was configured with one six-blade Rushton impeller with a diameter of 2.5 cm, three baffles, one ring sparger, and ports for acid, base, antifoam, and sampling. The fermenters were equipped with probes and controllers of pH, pO.sub.2, temperature, and antifoam to measure and control these parameters, respectively. Optimal fermenter conditions were the following. The fermenter was inoculated with 10% of cells at A600 of 5 growing at the mid-exponential phase. The pH was controlled at 5.5 using 2 M sodium hydroxide or 2 M of sulphuric acid. The foam was controlled by adding Antifoam C (Sigma Cat. No. A8011). The temperature was controlled at 20 C. using a heater jacket or chiller. The dissolved oxygen was controlled at 70% of air saturation by using cascade changes in agitation (400-1200 rpm), and a constant air flow rate of 1 VVM.
Calculation of Fermentation Parameters
[0432] Specific growth rates (p) was calculated across all the growth phases using the logarithm method. Yield of sugar conversion to biomass (Yxs) was calculated using the total biomass produced over the consumed substrate. The specific consumption rate of glucose (qs) and the specific production rates of carotenoids (qp) and AX (qpax) were computed at all the growth phases by multiplying the specific growth rate by the linear correlations of sugar or carotenoids and AX with biomass. For the stationary phase in which no-growth was observed, the specific rates were calculated using the linear correlations of sugar or carotenoid production with an average of biomass multiplied by its time frame.
Results
Instrumented Fermenters and Kinetic Analyses
[0433] The wild-type X. dendrorhous CBS 6938 and the mutant X. dendrorhous BPAX-A1 (referred to as MYM0 in Example 1) strains were grown for three days in a chemically defined media and sampled for growth and production measurements. Comparatively, as can be seen in Table 9, the wild-type final biomass was 13.600.29 gDCW/L, which represented 35.8% higher than that obtained in the mutant strain. The wild-type sugar to biomass yield (Yxs) was 0.62 g/gDCW being 44% higher than that obtained in the mutant strain. In terms of AX production, the mutant strain presented an improvement of around 11-fold compared to the wild-type strain. The final proportion of AX was around 70% for both strains. In terms of specific rates, as can be seen in Table 10 and
Metabolite Profiling of Wild-Type and Mutant Strains of X. Dendrorhous
[0434]
Comparative Transcriptomics Analysis
[0435] Cells from Phase 3 were used for differential transcriptomic analysis. RNA-sequencing was used to compare the transcriptional profile of the strains. Our analyses identified 6363 transcribed genes, of which 690 were significantly different (q<0.05). From these genes, 211 (132<Log 2 2) were downregulated and 479 (228>Log 2 2) were upregulated (Table 16).
[0436] CED82283), and ATP-Synthase genes (CDZ96150 and CDZ96333) (see Table 17 and
DISCUSSION
[0437] In Example 1, comparative genomics was explored to link phenotype and genotype of the mutant strain X. dendrorhous BPAX-A1 (MYM0). However, metabolic changes associated with improved AX production remained unclear. In this example, to gain metabolic insight, the wild-type and mutant strains were grown in chemically defined media and sampled at four growth phases for kinetic and metabolic comparisons. No substantial lag-phase was observed in either strain, and carotenoid production appeared primarily associated with growth. Principal Component Analysis (PCA) of all metabolites grouped the growth phases between and among the strains under comparison. Growth Phase III was fully isolated in the PCA analysis (see
Comparative Metabolomics
[0438] To study metabolic changes, a system-level characterization was performed, previously shown to be useful (Luna-Flores et al., 2016, 2018). Extracellular and intracellular metabolites were measured across the fermentation time course (
[0439] In this example, metabolites associated with the PPP were more abundant in the wild-type strain than in the mutant strain (
[0440] During the growth phase, the mutant strain showed abundance of metabolites associated with glycolysis, TCA cycle, amino acids, and fatty acids metabolites, but at the stationary phase, except for amino acids, most of these metabolites were more abundant in the wild-type strain. Similarly, metabolites of the TCA cycle namely succinate, fumarate and a-ketoglutarate were more abundant in the mutant strain than the wild-type strain during all the growth phases studied (
[0441] In regard to lipids, linoleic acid, palmitoleic acid, and stearic acid were the most abundant fatty acids in both strains. At Phase IV or stationary phase, the mutant strain presented 1.15-fold more palmitoleic acid, 1.17-fold more steric acid, and 1.41-fold less linoleic acid than the wild-type strain. Similarly to linoleic acid, all the other fatty acids were decreased in the mutant strain suggesting changes in the final fatty acid profile between the strains under study. Also, amino acids associated with the TCA cycle were more abundant in the mutant strain than in the wild-type strain. This Phase IV also matched with a switch in pH control including use of acid instead of base to maintain the pH at the desired level. The production of carotenoid ceased but AX continued increasing mainly due to a change in the composition of the total carotenoids. All collected data at Phase 4 suggest that the mutant strain was consuming lipids and peptides to obtain energy and metabolic precursors to continue producing AX.
Integrating Transcriptomics Respiratory and Energy Metabolism
[0442] For Example 1, a genomic variant analysis was performed in mutant strains including X. dendrorhous BPAX-A1. This genomic analysis found mutations in the electron respiratory chain pathway and metabolomics analysis suggested changes in the TCA cycle associated with the electron respiratory chain. In Example 1, a subset of mutations that were considered of particular interest were identified. Notably, some of these mutated genes were overexpressed based on transcriptomic analysis (see Table 15, Table 16, and Table 17). For example, a mutation in the succinate dehydrogenase or complex II gene (CDZ981393) was identified; this gene was significantly upregulated in the mutant strain (Log 2 2.8, q<0.05). Also, the complex I or NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 (CDZ96154) gene was mutated with two intron variants and this gene was significantly upregulated in transcriptomics (Log 2 4.73, q<0.05). The complex I or the NADH dehydrogenase subunit 4 (CDZ96151) gene had two mutations and was significantly upregulated in transcriptomics (Log 2 4.13, q<0.05). Similarly, cytochrome b gene CED80058 was mutated in the upstream and in the downstream of the gene; these mutations might be responsible for the significantly upregulated gene CED80058 in transcriptomics (Log 2 5.15, q<0.05) (
[0443] IV protein contains two copper catalytic centres (Cua and Cub), copper supplementation has been associated with an increase of AX production in X. dendrorhous (Srinivasan and Avadhani, 2012; Martinez-Cardenas et al., 2018). The ATP synthase subunit 6 gene CDZ96150 had two mutations in the upstream of the gene, and two other mutations in the downstream of the gene. Similarly, the ATP synthase subunit mitochondrial gene CDZ96333 had two mutations in the downstream of the gene. These CDZ96150 and CDZ96333 genes were significantly upregulated in transcriptomics (Log 2 5.25, q<0.05) and (Log 2 4.65, q<0.05), respectively. In X. dendrorhous, AX is utilized by oxidation of P-carotene through the P450 enzyme AX synthase (Ojima et al., 2006). This reaction needs the adjunct activity of the cytochrome P450 reductase or the cytochrome b as an electron donor (Alcaino et al., 2008a). Although no mutation was found in the AX synthase gene (CED83940), this gene was significantly upregulated in transcriptomics (Log 2 2.23, q<0.05).
[0444] Similarly, the cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies gene (CED84998) and the cytochrome P450 CYP4/CYP19/CYP26 subfamilies gene (CDZ98632) were significantly upregulated (Log 2 4.05, q<0.05) and (Log 2 1.45, q<0.05), respectively. Interestingly, the cytochrome P450 CYP2 subfamily (CED85015) was significantly downregulated (Log 2 2.30, q<0.05). Cytochrome P450 reductase (crtR) of X. dendrorhous has been cloned and found to be an essential gene for AX biosynthesis (Alcaino et al., 2008b). That study suggested that only one crtR is required for AX biosynthesis. However, the disruption of that gene in X. dendrorhous was not lethal suggesting the existence of an alternative electron donor such as the cythochrome b5. Here, upregulation of two crtR genes (CED84998 and CDZ98632) and downregulation of another one (CED85015) was observed. No significant overexpression of cytochrome b5 was observed.
[0445] Significant upregulation of the Ferredoxin/adrenodoxin reductase gene (CDZ98521) (Log 2 2.30, q<0.05) was observed. Ferredoxin/adrenodoxin reductase can transport electrons from a FADH2 coenzyme, produced during p-oxidation of lipids by the action of the acyl-CoA dehydrogenase, to a P450 systems of the mitochondria (Hanukoglu, 1992). Linked with this reaction step, here significant upregulation of an acyl-CoA dehydrogenase gene (CED84717) (Log 2 1.36, q<0.05) was observed, which is involved in the initial step of p-oxidation of lipids and production FADH2. This upregulated lipid degradation to provide FADH2 cofactors is potentially associated with the ongoing change in proportion of AX in the mutant strain BPAX-A1 after glucose was depleted and in its change of final lipids profile in which linoleic acid was 1.41-fold less than the wild-type.
[0446] Although not significant, all the other carotenoid-associated production genes (GGPP synthase, phytoene synthase, phytoene dehydrogenase, and lycopene cyclase) were nominally upregulated in transcriptomics in the mutant strain BPAX-A1 (Table 17). Linked to the TCA cycle, the a-ketoglutarate dehydrogenase gene (CED83799) was upregulated in transcriptomics in the mutant strain (Log 2 1.55, q<0.05) and downregulated the isocitrate lyase gene (CED85129)(Log 2 1.24, q<0.05). This suggests that the mutant strain is not using the glyoxylate shunt to deal with cell oxidative stress (Ahn et al., 2016), but the improved amounts of AX produced. Also, the asparagine synthase gene (CED83843) was upregulated in the mutant strain (Log 2 2.11, q<0.05). Asparagine is a TCA cycle derived (from oxaloacetate) amino acid which was more abundant in the mutant strain than in the wild-type strain (
Oxidative Stress Response in X. Dendrorhous
[0447] Carotenoids, including AX, present antioxidant properties that have been associated with survival mechanisms in X. dendrorhous and other microorganisms (Schroeder and Johnson, 1995). Normally, ROS are generated by an overflow of electrons in the electron respiratory chain triggered by an imbalance of electrons transfer during the reduction and oxidation of the ubiquinone pool. AX can quench ROS analogously to the superoxide dismutase. In this example, it was observed that the mutant strain upregulated genes associated with the electron transport chain that in turn triggered mechanisms associated with protection against ROS. First, the AX and total carotenoids accumulation in the mutant strain was significantly higher (p<05) than the ones found in the wild-type strain across all the growth and production phases (
[0448] Second, in yeast, hydrogen peroxide is increased during p-oxidation of lipids in the peroxisome, which can be neutralized by catalases (Yin et al., 2009). It has been reported that X. dendrorhous shows low activity of this enzyme (Schroeder and Johnson, 1995). Here, at the transcriptome level, two catalases genes were significantly upregulated in the mutant strain: the CDZ96425 (Log 2 2.89, q<0.05) and CDZ98863 (Log 2 1.91, q<0.05) genes, respectively. This suggests that the mutant X. dendrorhous strain may use catalases as a mechanism to alleviate oxidative stresses. And third, a report suggests that X. dendrorhous uses an antioxidant core which is modulated by the carotenoid production including monooxygenases, a cytochrome P450 enzyme, phosphoglucomutase, and glyceraldehyde 3-phosphate (Flores-Cotera et al., 2001; Martinez-Moya et al., 2015).
[0449] It is reported that X. dendrorhous showed low levels of superoxide dismutase, or glutathione peroxidase enzymes under inductions with single oxygen and peroxyl radicals (Schroeder and Johnson, 1995). However, in a separate study, at the proteome level, it was identified activity of the superoxide dismutase and some glutathione enzymes when grown on succinate as a carbon source, which increased AX by 2.33-fold (Martinez-Moya et al., 2015). In agreement with that study, here two glutathione-S-transferase genes were significantly upregulated in the mutant strain: CED84930 (Log 2 6.09, q<0.05) and CDZ97957 (Log 2 5.72, q<0.05) (Table 16 and Table 17). It is reported that the glutathione S-transferases counteract the mutagenic effect of aldehyde products of lipid peroxidation (Ames et al., 1993). Generally, glutathione, glutathione enzymes, and superoxide dismutase are used as oxidative stress biomarkers in trials to evaluated the antioxidant effect of certain chemicals or drugs (Ames et al., 1993). Using these markers, AX has shown to be effective to stimulate these oxidative stress mechanisms in rainbow trout (Elia et al., 2019). In addition, the highest overexpressed gene in the mutant strain was the conidiation-specific protein 6 gene (CED85080) (Log 2 9.29, q<0.05). This protein has been associated with survival mechanisms against environmental stresses (Zhang et al., 2016). Overall, the mutant strain showed upregulation of the electron transport chain which might increased ROS triggering some protective oxidative stress mechanisms including higher AX production, upregulation of AX synthase, P450 reductase, and glutathione-related genes.
Lipid Biosynthesis
[0450] The fatty acid pathway in X. dendrorhous has been elucidated (Sharma et al., 2015). The synthesis starts with the acetyl CoA carboxylase and the acyl carrier protein (ACP) for the formation of acetyl-ACP and malonyl-ACP, which is followed by condensations, ketoacyl reduction, a dehydratase reaction, and enoyl reduction all the way to palmityl-CoA are catalyzed by two multi-enzyme complexes FAS1 and FAS2. The FAS1 has functional domains of malony transferase, enoly reductase, hydroxyacyl dehydratase, and malony/palmitoyl transferase and FAS2 has functional groups of ketoacyl reductase, ketoacyl synthase, and phosphopantetheinyl transferase. The additional genes involved in the elongation of C16 to C18 fatty acid by the fatty acid elongase, and the insertion of a delta-9 and a delta-12 double bond by delta 9 fatty acid desaturase, and delta 12 fatty acid desaturase, respectively. From the mitochondrial fatty acid enzymes, palmitic acid can be synthesised by palmitoyl thioesterase from palmytil-ACP. Condensation, ketoacyl reduction, dehydratase, and enoyl-reduction can be also carried out by acetyl-CoA acyltransferase, 2 ketoacyl reductase, enoyl-CoA hydratase, or 3-hydroxyacyl CoA dehydrogenase, respectively.
[0451] In this example, another mutation was found in the delta 9 fatty acid desaturase. A report suggest that this enzyme has preferences for substrates of C18:1 and C16:1 converting to C18:2 and C16:2 fatty acids (L. Zhang et al., 2020). The most abundant fatty acids in the P. rhodozyma pathway are linoleate (C18:2), stearic acid (18:0), oleic acid (C18:1), palmitic acid (C16:1), and hexadecanoic acid (16:2) (Sharma et al., 2015). Although not significant, the delta 9 fatty acid desaturase gene (CED83656) was nominally downregulated in the mutant strain (Log 2 0.53, q>0.05). This suggests that delta 9 fatty acid desaturase might be influencing the fatty acid pathway in the novel strains of P. rhodozyma. A decrease in the fatty acid and ergosterol metabolism in P. rhodozyma increased AX production (Miao et al., 2011). Also, the FAS1 gene (CED83610) was significantly upregulated in the mutant strain (Log 2 1.92, q<0.05). Similarly, the delta-6-desaturase gene (CED83550) was significantly upregulated (Log 2 1.38, q<0.05). This gene is the first step in the degradation of linoleic acid before to be utilised by the microorganism (Horrobin et al., 1993). Overall, these findings provide a possible explanation as to why linoleic acid was more abundant in the wild-type strain than in the mutant strain at the end of the fermentation.
Example 3: Proteomic Analysis of a High Astaxanthin Producer Strain of Xanthophyllomyces dendrorhous
[0452] In this example, proteomic analysis was performed to complement the metabolomic and transcriptomic analysis of Example 2.
Materials and Methods
Strains, Media, and Growth Conditions
[0453] Strains, media, and growth conditions were as for Example 2, above.
Proteomic Extraction, Quantification, Digestion, and SWATH Analyses.
[0454] Samples equivalent to 20-50 A600 units were harvested from the instrumented fermenters at Growth Phase 3 and Growth Phase 4 as described in Example 2. Cells were pelleted at 14000g for 5 min at 4 C. The supernatant was discarded, and the pellet was washed twice with ice-cold water. The washed pellet was then re-suspended in 2 mL of sodium dodecyl sulfate (SDS) lysis buffer and transferred to a tubes containing 0.5 g of acid washed glass beads (Sigma Cat. No. G1152-100G). The tubes were chilled on ice for 5 minutes and then disrupted using five bead-beating cycles of 5 min using a Qiagen Tissue Lyser II. After disruption, the tubes were centrifuged at 14000g for 10 min at 4 C.
[0455] The extracted proteins were quantified using the Pierce BCA Protein Assay Kit (ThermoFisher Cat. No. 23225). The FASP and C18 StageTip protocols were then applied to digest the extracted proteins and desalt the peptides, respectively (Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, 2009). The peptides of digested samples were quantified using the Pierce Quantitative Colorimetric Peptide Kit (ThermoFisher Cat. No. 23275) and used to normalize their concentration before submitting the samples to mass spectrometry (MS) analysis. The sequential window acquisition of all theoretical mass spectra (SWATH) technique was then applied to the peptide samples using the Sciex 5600 QTOF (Yeo et al., 2016).
[0456] To prepare the library, a mixture of all peptide samples (PBQC) was MS analysed in Data Dependent Acquisition mode (DDA). For this, ProteinPilot 5.0.2 was first used to identify proteins using the Paragon method and the published and annotated P. rhodozyma CBS6938 genome using a quality threshold of 1.3 (95%) (Sharma et al., 2015). Skyline was then used to create the spectral library and SWATH mode analysed samples. Differential proteome expression was assessed between the mutant X. dendrorhous BPAX-A1 (referred to as MYM0 in Example 1) and wild-type X. dendrorhous CBS 6938 at Phase 3 and Phase 4.
Results
[0457] Differential protein expression results are set out for Growth Phase 3 in
Example 4: Products Incorporating Astaxanthin
[0458] This example provides details of certain typical formulation for supplementing domestic or companion animals, the formulation including astaxanthin produced as herein described. The formulation may be referred to as NatuAX, although without limitation thereto.
[0459] The formulations are also rich in dietary fibre, vitamins, beta-glucan, and amino acids. An analysis of fatty acid profile for the formulations is provided in
[0460] Formulations for feline, canine, and equine use have been developed. All formulations include astaxanthin and beta-glucans.
[0461] In general, astaxanthin may provide benefits including: [0462] Antioxidant activity for supporting the immune system [0463] Mitochondrial protection against reactive oxygen species [0464] Reduction in cellular damage and lipid peroxidation [0465] Improve response and processing of antigens
[0466] In general, beta-glucans may provide benefits including: [0467] Stimulation of the immune system [0468] Reduction of blood concentration of total cholesterol [0469] Antioxidant properties [0470] Reduction of inflammatory response
[0471] Equine variations comprise polyphenols, which may provide benefits including: [0472] Combat inflammation and the natural aging process (inflamm-aging) [0473] Decrease the amount of non-steroidal anti-inflammatory drugs administered to older horses [0474] Antioxidant activity for reducing oxidative stress and improve immune function [0475] Support muscle recovery in endurance horses
Specifications for the feline, canine, and equine formulations are as follows:
Feline
Component Percentages:
[0476] Astaxanthin: 0.25%=2.5 g/kg [0477] beta-Glucan: 15%=150 g/kg [0478] Carriers: =847.5% g/kg=847.5 g/kg
Minimum and Maximum Recommended Dose Rates:
[0479] Adult cats<5 kg: 1 g/day [0480] Adult cats>5 kg: 2 g/day [0481] Kittens and geriatric cats: 2 g/day
Canine
Component Percentages:
[0482] Astaxanthin: 0.25%=2.5 g/kg [0483] beta-Glucan: 15%=150 g/kg [0484] Carriers: =847.5% g/kg=847.5 g/kg
Minimum and Maximum Recommended Dose Rates:
[0485] Extra small dogs (8 kg)=1 g/day [0486] Small dogs (16 kg): 2 g/day [0487] Medium dogs (24 kg): 3 g/day [0488] Large dogs (32 kg): 4 g/day [0489] Extra large dogs (40 kg): 5 g/day
(Puppies and Geriatric Dogs Require Double the Recommended Dose)
Equine
Component Percentages:
[0490] Astaxanthin: 0.075%=0.75 g/kg [0491] beta-Glucan: 4.22%=42.2 g/kg [0492] Polyphenols: 2.5%=25 g/kg [0493] Carriers: 93.21% g/kg=932.05 g/kg
Minimum and Maximum Recommended Dose Rates:
[0494] 100 g per day orally or mixed in feed
[0495] (Horses in poor condition or commencing training require double the recommended dose for the first 3 weeks)
REFERENCES
[0496] Adams, K. J., Pratt, B., Bose, N., Dubois, L. G., St. John-Williams, L., Perrott, K. M., Ky, K., Kapahi, P., Sharma, V., Maccoss, M. J., Moseley, M. A., Colton, C. A., Maclean, B. X., Schilling, B., Thompson, J. W., 2020. Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics. J. Proteome Res. 19, 1447-1458. doi.org/10.1021/acs.jproteome.9b00640 [0497] Ahn, S., Jung, J., Jang, I. A., Madsen, E. L., Park, W., 2016. Role of glyoxylate shunt in oxidative stress response. J. Biol. Chem. 291, 11928-11938. doi.org/10.1074/jbc.M115.708149 [0498] Alcano, J., Barahona, S., Carmona, M., Lozano, C., Marcoleta, A., Niklitschek, M., Seplveda, D., Baeza, M., Cifuentes, V., 2008a. Cloning of the cytochrome p450 reductase (crtR) gene and its involvement in the astaxanthin biosynthesis of Xanthophyllomyces dendrorhous. BMC Microbiol. 8, 1-13. doi.org/10.1186/1471-2180-8-169 [0499] Alcano, J., Barahona, S., Carmona, M., Lozano, C., Marcoleta, A., Niklitschek, M., Seplveda, D., Baeza, M., Cifuentes, V., 2008b. Cloning of the cytochrome p450 reductase (crtR) gene and its involvement in the astaxanthin biosynthesis of Xanthophyllomyces dendrorhous. BMC Microbiol. 8. doi.org/10.1186/1471-2180-8-169 [0500] Ambati, R. R., Moi, P. S., Ravi, S., Aswathanarayana, R. G., 2014. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applicationsA review. Mar. Drugs 12, 128-152. doi.org/10.3390/md12010128 [0501] Ames, B. N., Shigenaga, M. K., Hagen, T. M., 1993. Oxidants, antioxidants, and the degenerative diseases of aging (cancer/mutation/endogenous DNA adducts/oxygen radicals), Proc. Natl. Acad. Sci. USA. [0502] An, G. H., 2001. Improved growth of the red yeast, Phaffia rhodozyma (Xanthophyllomyces dendrorhous), in the presence of tricarboxylic acid cycle intermediates. Biotechnol. Lett. 23, 1005-1009. doi.org/10.1023/A:1010523800650 [0503] An, G. H., Jang, B. G., Cho, M. H., 2001. Cultivation of the carotenoid-hyperproducing mutant 2A2N of the red yeast Xanthophyllomyces dendrorhous (Phaffia rhodozyma) with molasses. J. Biosci. Bioeng. 92, 121-5. doi.org/10.1263/jbb.92.121 [0504] An, G. H., Schuman, D. B., Johnson, E. A., 1989. Isolation of Phaffia rhodozyma Mutants with Increased Astaxanthin Content. Appl. Environ. Microbiol. 55, 116-24. [0505] Andrews, S., 2010. FastQC: A quality control tool for high throughput sequence data [WWW Document]. Online. URL www.bioinformatics.babraham.ac.uk/projects/fastqc/ [0506] Auch, A. F., Klenk, H.-P., Gker, M., 2010. Standard operating procedure for calculating genome-to-genome distances based on high-scoring segment pairs. Stand. Genomic Sci. 2, 142-8. doi.org/10.4056/sigs.541628 [0507] Auwera, G. A., Carneiro, M. O., Hartl, C., Poplin, R., del Angel, G., Levy-Moonshine, A., Jordan, T., Shakir, K., Roazen, D., Thibault, J., Banks, E., Garimella, K. V., Altshuler, D., Gabriel, S., DePristo, M. A., 2013. From FastQ Data to High-Confidence Variant Calls: The Genome Analysis Toolkit Best Practices Pipeline. Curr. Protoc. Bioinforma. 43, 11.10.1-11.10.33. doi.org/10.1002/0471250953.bi1110s43 [0508] Bergstrom, J. R., Nelssen, J. L., Tokach, M. D., Bergstrom, J. R.; Nelssen, J. L.; Tokach, M. D.; Derouchey, J. M.; Goodband, R. D.; Dritz, S. S., 1968. An evaluation of astaxanthin as a nutraceutical growth promoter An evaluation of astaxanthin as a nutraceutical growth promoter in starter diets for weanling pigs in starter diets for weanling pigs Recommended Citation Recommended Citation. Kansas Agric. Exp. Stn. Res. Reports 0. doi.org/10.4148/2378-5977.6963 [0509] Bolger, A. M., Lohse, M., Usadel, B., 2014. Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114-2120. doi.org/10.1093/bioinformatics/btu170 [0510] Bon, J. A., Leathers, T. D., Jayaswal, R. K., 1997. Isolation of astaxanthin-overproducing mutants of Phaffia rhodozyma. Biotechnol. Lett. 19, 109-112. doi.org/10.1023/A:1018391726206 [0511] Brhl, W. K., Hassloch, K. H., Neuhofen, J. P., Speyer, H. E., 1997. Preparation of astaxanthin. [0512] Calo, P., de Miguel, T., Velazquez, J. B., Villa, T. G., 1995. Mevalonic acid increases trans-astaxanthin and carotenoid biosynthesis in Phaffia rhodozyma. Biotechnol. Lett. 17, 575-578. [0513] Canelas, A. B., Ras, C., ten Pierick, A., van Dam, J. C., Heijnen, J. J., van Gulik, W. M., 2008. Leakage-free rapid quenching technique for yeast metabolomics. Metabolomics 4, 226-239. doi.org/10.1007/s11306-008-0116-4 [0514] Canelas, A. B., Ten Pierick, A., Ras, C., Seifar, R. M., Van Dam, J. C., Van Gulik, W. M., Heijnen, J. J., 2009. Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics. Anal. Chem. 81, 7379-7389. doi.org/10.1021/ac900999t [0515] Cannizzaro, C., Christensen, B., Nielsen, J., Stockar, U. Von, 2004. Metabolic network analysis on Phaffia rhodozyma yeast using 13C-labeled glucose and gas chromatography-mass spectrometry. Metab. Eng. 6, 340-351. doi.org/10.1016/j.ymben.2004.06.001 [0516] Capelli, B., Bagchi, D., Cysewski, G. R., 2014. Synthetic astaxanthin is significantly inferior to algal-based astaxanthin as an antioxidant and may not be suitable as a human nutraceutical supplement. Nutrafoods 2013 124 12, 145-152. doi.org/10.1007/S13749-013-0051-5 [0517] Capelli, B., Talbott, S., Ding, L., 2019. Astaxanthin sources: Suitability for human health and nutrition. Funct. Foods Heal. Dis. 9, 430-445. doi.org/10.31989/ffhd.v9i6.584 [0518] Chen, T., Speight, R., Sadowsky, P., Blanksby, S., 2020. COMPOSITIONAL ANALYSIS OF NEW MICROBIAL FEED SUPPLEMENTS PRODUCED FROM MEAT PROCESSING CO-PRODUCTS. Queensland University of Technology. [0519] Chumpolkulwong, N., Kakizono, T., Nagai, S., Nishio, N., 1997. Increased astaxanthin production by Phaffia rhodozyma mutants isolated as resistant to diphenylamine. J. Ferment. Bioeng. 83, 429-434. doi.org/10.1016/S0922-338X(97)82996-0 [0520] Chun, S. B., Chin, J. E., Bai, S., An, G. H., 1992. Strain improvement of Phaffia rhodozyma by protoplast fusion. FEMS Microbiol. Lett. 93, 221-226. doi.org/10.1016/0378-1097(92)90466-2 [0521] Cingolani, P., Platts, A., Wang, L. L., Coon, M., Nguyen, T., Wang, L., Land, S. J., Lu, X., Ruden, D. M., 2012. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w 1118; iso-2; iso-3. Fly (Austin). 6, 80-92. doi.org/10.4161/fly.19695 [0522] Cruz, J. M., Parajo, J. C., 1998. Improved astaxanthin production by Xanthophyllomyces dendrorhous growing on enzymatic wood hydrolysates containing glucose and cellobiose. Food Chem. 63, 479-484. doi.org/10.1016/S0308-8146(98)00061-2 [0523] De Livera, A. M., Dias, D. A., De Souza, D., Rupasinghe, T., Pyke, J., Tull, D., Roessner, U., McConville, M., Speed, T. P., 2012. Normalizing and integrating metabolomics data. Anal. Chem. 84, 10768-10776. doi.org/10.1021/ac302748b [0524] Dominguez-Bocanegra, A. R., Torres-Munoz, J. A., 2004. Astaxanthin hyperproduction by Phaffia rhodozyma (now Xanthophyllomyces dendrorhous) with raw coconut milk as sole source of energy. Appl. Microbiol. Biotechnol. 66, 249-252. doi.org/10.1007/s00253-004-1686-3 [0525] Elia, A. C., Prearo, M., Josef, A., Dorr, M., Pacini, N., Magara, G., Brizio, P., Gasco, L., Abete, M. C., 2019. Journal of Toxicology and Environmental Health, Part A Current Issues Effects of astaxanthin and canthaxanthin on oxidative stress biomarkers in rainbow trout Effects of astaxanthin and canthaxanthin on oxidative stress biomarkers in rainbow trout. J. Toxicol. Environ. Heal. Part A 82, 760-768. doi.org/10.1080/15287394.2019.1648346 [0526] Flores-Cotera, L. B., Chvez-Cabrera, C., Martinez-Crdenas, A., Snchez, S., Garca-Flores, O. U., 2021. Deciphering the mechanism by which the yeast Phaffia rhodozyma responds adaptively to environmental, nutritional, and genetic cues. J. Ind. Microbiol. Biotechnol. 48. doi.org/10.1093/jimb/kuab048 [0527] Flores-Cotera, L. B., Martin, R., Snchez, S., 2001. Citrate, a possible precursor of astaxanthin in Phaffia rhodozyma: Influence of varying levels of ammonium, phosphate and citrate in a chemically defined medium. Appl. Microbiol. Biotechnol. 55, 341-347. doi.org/10.1007/s002530000498 [0528] Flores-Cotera, L. B., Snchez, S., 2001. Copper but not iron limitation increases astaxanthin production by Phaffia rhodozyma in a chemically defined medium. Biotechnol. Lett. 23, 793-797. doi.org/10.1023/A:1010358517806 [0529] Fomtana, J. D., Guimares, M. F., Martins, N. T., Fontana, C. A., Baron, M., 1996. Culture of the astaxanthinogenic yeast Phaffia rhodozyma in low-cost media. Appl. Biochem. Biotechnol. 57-58, 413-422. doi.org/10.1007/BF02941721 [0530] Fontana, J. D., Chocial, M. B., Baron, M., Guimaraes, M. F., Maraschin, M., Ulhoa, C., Florncio, J. a, Bonfim, T. M., 1997. Astaxanthinogenesis in the yeast Phaffia rhodozyma: optimization of low-cost culture media and yeast cell-wall lysis. Appl. Biochem. Biotechnol. 63-65, 305-14. doi.org/10.1007/BF02920432 [0531] Fontana, J. D., Czeczuga, B., Bonfim, T. M. B., Chociai, M. B., Oliveira, B. H., Guimares, M. F., Baron, M., 1996. Bioproduction of carotenoids: The comparative use of raw sugarcane juice and depolymerized bagasse by Phaffia rhodozyma. Bioresour. Technol. 58, 121-125. doi.org/10.1016/S0960-8524(96)00092-2 [0532] Fu, Y. H., Marzluf, G. A., 1990. nit-2, the major nitrogen regulatory gene of Neurospora crassa, encodes a protein with a putative zinc finger DNA-binding domain. Mol. Cell. Biol. 10, 1056-1065. doi.org/10.1128/mcb.10.3.1056 [0533] Gassel, S., Schewe, H., Schmidt, I., Schrader, J., Sandmann, G., 2013. Multiple improvement of astaxanthin biosynthesis in Xanthophyllomyces dendrorhous by a combination of conventional mutagenesis and metabolic pathway engineering. Biotechnol. Lett. 35, 565-569. doi.org/10.1007/s10529-012-1103-4 [0534] Gil-Hwan, A. N., Schuman, D. B., Johnson, E. A., 1989. Isolation of Phaffia rhodozyma mutants with increased astaxanthin content. Appl. Environ. Microbiol. 55, 116-124. doi.org/10.1128/aem.55.1.116-124.1989 [0535] Goldstein, J. L., Brown, M. S., 1990a. Regulation of the mevalonate pathway. Nature 343, 425-430. doi.org/10.1038/343425a0 [0536] Goldstein, J. L., Brown, M. S., 1990b. Regulation of the mevalonate pathway. Nature. doi.org/10.1038/343425a0 [0537] Grinberg, A. V., Hannemann, F., Schiffler, B., Miller, J., Heinemann, U., Bernhardt, R., 2000. Adrenodoxin: Structure, stability, and electron transfer properties. Proteins Struct. Funct. Genet. 40, 590-612. doi.org/10.1002/1097-0134(20000901)40:4<590::AID-PROT50>3.0.CO;2-P [0538] Gu, W. L., An, G. H., Johnson, E. a, 1997. Ethanol increases carotenoid production in Phaffia rhodozyma. J. Ind. Microbiol. Biotechnol. 19, 114-117. doi.org/10.1038/sj.jim.2900425 [0539] Haard, N. F., 1988. Astaxanthin formation by the yeast Phaffia rhodozyma on molases. Biotechnol. Lett. 10, 609-614. [0540] Hanukoglu, I., 1992. Steroidogenic enzymes: Structure, function, and role in regulation of steroid hormone biosynthesis. J. Steroid Biochem. Mol. Biol. 43, 779-804. doi.org/10.1016/0960-0760(92)90307-5 [0541] Hara, K. Y., Morita, T., Mochizuki, M., Yamamoto, K., Ogino, C., Araki, M., Kondo, A., 2014. Development of a multi-gene expression system in Xanthophyllomyces dendrorhous. Microb. Cell Fact. 13, 175. doi.org/10.1186/s12934-014-0175-3 [0542] Hasan, M., Azhar, M., Nangia, H., Bhatt, P. C., Panda, B. P., 2016. Influence of High Pressure Homogenization, Ultra-Sonication and Supercritical Fluid on Free Astaxanthin Extraction From -Glucanase Treated Phaffia rhodozyma Cells. Prep. Biochem. Biotechnol. 0, 150527100841001. doi.org/10.1080/10826068.2014.995807 [0543] Higashida, K., Nakashimada, Y., Kakizono, T., Nishio, N., 1997. Influence of Oxygen and Glucose on Primary Metabolism and Astaxanthin Production by Phaffia rhodozyma in Batch and Fed-Batch Cultures: Kinetic and Stoichiometric Analysis. Microbiology 63, 4471-4478. [0544] Higuera-Ciapara, I., Flix-Valenzuela, L., Goycoolea, F. M., 2006. Astaxanthin: a review of its chemistry and applications. Crit. Rev. Food Sci. Nutr. 46, 185-96. doi.org/10.1080/10408690590957188 [0545] Honda, T., Takahashi, J., Aichi-Ken, J., Toyama-ken, J., 2007. ASTAXANTHIN-CONTAINING PET FOODS. US 2007/0128310 A1. [0546] Horrobin, D. F., Crawford, M. A., Vergroesen, A. J., Horrobin, D. F., 1993. Fatty acid metabolism in health and disease: The role of -6-desaturase, in: American Journal of Clinical Nutrition. Am J Clin Nutr. doi.org/10.1093/ajcn/57.5.732S [0547] Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, M. M. (2009) Universal sample preparation method for proteome analysis. Nat Methods 6: 377-362. [0548] Jian, X., Boerwinkle, E., Liu, X., 2013. In silico tools for splicing defect prediction: a survey from the viewpoint of end users. doi.org/10.1038/gim.2013.176 [0549] Johnson, E. a., An, G.-H., 1991. Astaxanthin from Microbial Sources. Crit. Rev. Biotechnol. 11, 297-326. doi.org/10.3109/07388559109040622 [0550] Kajiwara, S., Fraser, P. D., Kondo, K., Misawa, N., 1997. Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli. Biochem. J. 324, 421-426. doi.org/10.1042/bj3240421 [0551] Krogh, A., Larsson, B., Von Heijne, G., Sonnhammer, E. L. L., 2001. Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes. J. Mol. Biol. 305, 567-580. doi.org/10.1006/jmbi.2000.4315 [0552] Kryvokhyzha, D., 2016. GATK the best practice for a non-model organism [WWW Document]. URL evodify.com/gatk-in-non-model-organism/ [0553] Langmead, B., Salzberg, S. L., 2012. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357-9. doi.org/10.1038/nmeth.1923 [0554] Lengger, B., Jensen, M. K., 2020. Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes. FEMS Yeast Res. doi.org/10.1093/femsyr/foz087 [0555] Lewis, M. J., Ragot, N., Berlant, M. C., Miranda, M., 1990. Selection of astaxanthin-overproducing mutants of Phaffia rhodozyma with B-ionone. Appl. Environ. Microbiol. 56, 2944-2945. [0556] Li, H., Durbin, R., 2010. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589-595. doi.org/10.1093/bioinfornatics/btp698 [0557] Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., 2009. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-9. doi.org/10.1093/bioinformatics/btp352 [0558] Li, X., Wang, X., Duan, C., Yi, S., Gao, Z., Xiao, C., Agathos, S. N., Wang, G., Li, J., 2020. Biotechnological production of astaxanthin from the microalga Haematococcus pluvialis. Biotechnol. Adv. 43, 107602. doi.org/10.1016/J.BIOTECHADV.2020.107602 [0559] Libkind, D., Moline, M., Van Broock, M., 2011. Production of the UVB-absorbing compound mycosporine-glutaminol-glucoside by Xanthophyllomyces dendrorhous (Phaffia rhodozyma). FEMS Yeast Res. 11, 52-59. doi.org/10.1111/j.1567-1364.2010.00688.x [0560] Liu, X., Osawa, T., 2007. Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer. Biochem. Biophys. Res. Commun. 357, 187-193. doi.org/10.1016/J.BBRC.2007.03.120 [0561] Liu, Y. S., Wu, J. Y., 2006. Hydrogen peroxide-induced astaxanthin biosynthesis and catalase activity in Xanthophyllomyces dendrorhous. Appl. Microbiol. Biotechnol. 73, 663-668. doi.org/10.1007/s00253-006-0501-8 [0562] Luna-Flores, C. H., Palfreyman, R. W., Krmer, J. O., Nielsen, L. K., Marcellin, E., 2016. Improved production of propionic acid using genome shuffling. Biotechnol. J. 1-12. doi.org/10.1002/biot.201600120 [0563] Luna-Flores, C. H., Ramirez-Cordova, J. J., Pelayo-Ortiz, C., Femat, R., Herrera-Lpez, E. J., 2010. Batch and fed-batch modeling of carotenoids production by Xanthophyllomyces dendrorhous using Yucca fillifera date juice as substrate. Biochem. Eng. J. 53, 131-136. doi.org/10.1016/j.bej.2010.10.004 [0564] Luna-Flores, C. H., Stowers, C. C., Cox, B. M., Nielsen, L. K., Marcellin, E., 2018. Linking genotype and phenotype in an economically viable propionic acid biosynthesis process. Biotechnol. Biofuels 11, 224. doi.org/10.1186/s13068-018-1222-9 [0565] Luna-Flores, C. H., Stowers, C. C., Cox, B. M., Nielsen, L. K., Marcellin, E., 2017. Scalable and economical process for propionic acid biosynthesis. Biotechnol. Biofuels Submitted. [0566] Martinez-Crdenas, A., Chvez-Cabrera, C., Vasquez-Bahena, J. M., Flores-Cotera, L. B., 2018. A common mechanism explains the induction of aerobic fermentation and adaptive antioxidant response in Phaffia rhodozyma. Microb. Cell Fact. 17, 53. doi.org/10.1186/s12934-018-0898-7 [0567] Martinez-Moya, P., Niehaus, K., Alcaino, J., Baeza, M., Cifuentes, V., 2015. Proteomic and metabolomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous using different carbon sources. BMC Genomics 16, 1-18. doi.org/10.1186/s12864-015-1484-6 [0568] Mendez, K. M., Pritchard, L., Reinke, S. N., Broadhurst, D. I., 2019. Toward collaborative open data science in metabolomics using Jupyter Notebooks and cloud computing. Metabolomics 15, 1-16. doi.org/10.1007/sI1306-019-1588-0 [0569] Miao, L., Chi, S., Tang, Y., Su, Z., Yin, T., Guan, G., Li, Y., 2011. Astaxanthin biosynthesis is enhanced by high carotenogenic gene expression and decrease of fatty acids and ergosterol in a Phaffia rhodozyma mutant strain. FEMS Yeast Res. 11, 192-201. doi.org/10.1 111/j.1567-1364.2010.00705.x [0570] Miller, G. L., 1959. Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar. Anal. Chem. 31, 426-428. doi.org/10.1021/ac60147a030 [0571] Misawa, N., 2021. Carotenoids: Biosynthetic and Biofunctional Approaches. [0572] Moretti, V. M., Mentasti, T., Bellagamba, F., Luzzana, U., Caprino, F., Turchini, G. M., Giani, I., Valfr, F., 2006. Determination of astaxanthin stereoisomers and colour attributes in flesh of rainbow trout (Oncorhynchus mykiss) as a tool to distinguish the dietary pigmentation source. Food Addit. Contain. 23, 1056-63. doi.org/10.1080/02652030600838399 [0573] Mussagy, C. U., Pereira, J. F. B., Dufoss, L., Raghavan, V., Santos-Ebinuma, V. C., Pessoa, A., 2021. Advances and trends in biotechnological production of natural astaxanthin by Phaffia rhodozyma yeast. Crit. Rev. Food Sci. Nutr. 0, 1-15. doi.org/10.1080/10408398.2021.1968788 [0574] Najafi, N., Ahmadi, A.-R., Hosseini, R., Golkhoo, S., 2011. Gamma irradiation as a useful tool for the isolation of astaxanthin-overproducing mutant strains of Phaffia rhodozyma. Can. J. Microbiol. 57, 730-734. doi.org/10.1139/W11-060 [0575] Ni, H., Chen, Q., Ruan, H., Yang, Y., Li, L., Wu, G., Hu, Y., He, G., 2007. Studies on optimization of nitrogen sources for astaxanthin production by Phaffia rhodozyma. J. Zhejiang Univ. Sci. B 8, 365-70. doi.org/10.1631/jzus.2007.B0365 [0576] Niklitschek, M., Alcaino, J., Barahona, S., Seplveda, D., Lozano, C., Carmona, M., Marcoleta, A., Martinez, C., Lodato, P., Baeza, M., Cifuentes, V., 2008. Genomic organization of the structural genes controlling the astaxanthin biosynthesis pathway of Xanthophyllomyces dendrorhous. Biol. Res. 41, 93-108. doi.org/10.4067/S0716-97602008000100011 [0577] Ojima, K., Breitenbach, J., Visser, H., Setoguchi, Y., Tabata, K., Hoshino, T., Van Den Berg, J., Sandmann, G., 2006. Cloning of the astaxanthin synthase gene from Xanthophyllomyces dendrorhous (Phaffia rhodozyma) and its assignment as a -carotene 3-hydroxylase/4-ketolase. Mol. Genet. Genomics 275, 148-158. doi.org/10.1007/s00438-005-0072-x [0578] Pan, X., Wang, B., Duan, R., Jia, J., Li, J., Xiong, W., Ling, X., Chen, C., Huang, X., Zhang, G., Lu, Y., 2020. Enhancing astaxanthin accumulation in Xanthophyllomyces dendrorhous by a phytohormone: metabolomic and gene expression profiles. Microb. Biotechnol. doi.org/10.1111/1751-7915.13567 [0579] Park, J. S., Kim, H. W., Mathison, B. D., Hayek, M. G., Massimino, S., Reinhart, G. A., Chew, B. P., 2010. Astaxanthin uptake in domestic dogs and cats. Nutr. Metab. 7, 52. doi.org/10.1186/1743-7075-7-52 [0580] Perenlei, G., Tojo, H., Okada, T., Kubota, M., Kadowaki, M., Fujimura, S., 2014. Effect of dietary astaxanthin rich yeast, Phaffia rhodozyma, on meat quality of broiler chickens. Anim. Sci. J. 85, 895-903. doi.org/10.1111/asj.12221 [0581] Reynders, M. B., Rawlings, D. E., Harrison, S. T. L., 1997. Demonstration of the Crabtree effect in Phaffia rhodozyma during continuous and fed-batch cultivation. Biotechnol. Lett. 19, 549-552. doi.org/10.1023/A:1018341421122 [0582] Rodriguez-Siz, M., De La Fuente, J. L., Barredo, J. L., 2010. Xanthophyllomyces dendrorhous for the industrial production of astaxanthin. Appl. Microbiol. Biotechnol. 88, 645-658. doi.org/10.1007/s00253-010-2814-x [0583] Rohmer, M., 1999. The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants. Nat. Prod. Rep. 16, 565-574. doi.org/10.1039/a709175c [0584] Sandmann, G., 1994. Carotenoid biosynthesis in microorganisms and plants. Eur. J. Biochem. 223, 7-24. doi.org/10.1111/j.1432-1033.1994.tb18961.x [0585] Schewe, H., Kreutzer, A., Schmidt, I., Schubert, C., Schrader, J., 2017. High concentrations of biotechnologically produced astaxanthin by lowering pH in a Phaffia rhodozyma bioprocess. Biotechnol. Bioprocess Eng. 22, 319-326. doi.org/10.1007/s12257-016-0349-4 [0586] Schmidt, H., Jirstrand, M., 2006. Systems Biology Toolbox for MATLAB: A computational platform for research in systems biology. Bioinformatics 22, 514-515. doi.org/10.1093/bioinformatics/bti799 [0587] Schmidt, I., Schewe, H., Gassel, S., Jin, C., Buckingham, J., Hmbelin, M., Sandmann, G., Schrader, J., 2011. Biotechnological production of astaxanthin with Phaffia rhodozyma/Xanthophyllomyces dendrorhous. Appl. Microbiol. Biotechnol. doi.org/10.1007/s00253-010-2976-6 [0588] Schneider, R., Brors, B., Massow, M., Weiss, H., 1997. Mitochondrial fatty acid synthesis: A relic of endosymbiontic origin and a specialized means for respiration. FEBS Lett. 407, 249-252. doi.org/10.1016/S0014-5793(97)00360-8 [0589] Schroeder, W. a, Johnson, E. a, 1993. Antioxidant role of carotenoids in Phaffia rhodozyma. J. Gen. Microbiol. 139, 907-912. doi.org/10.1099/00221287-139-5-907 [0590] Schroeder, W. A., Johnson, E. A., 1995. Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma. J. Biol. Chem. 270, 18374-18379. doi.org/10.1074/jbc.270.31.18374 [0591] Sedmak, J. J., Weerasinghe, D. K., Jolly, S. O., 1990. Extraction and quantification of astaxanthin from Phaffia rhodozyma. Biotechnol. Tech. 4, 107-112. [0592] Shah, M. M. R., Liang, Y., Cheng, J. J., Daroch, M., 2016. Astaxanthin-producing green microalga Haematococcus pluvialis: From single cell to high value commercial products. Front. Plant Sci. doi.org/10.3389/fpls.2016.00531 [0593] Sharma, R., Gassel, S., Steiger, S., Xia, X., Bauer, R., Sandmann, G., 2015. The genome of the basal agaricomycete Xanthophyllomyces dendrorhous provides insights into the organization of its acetyl-CoA derived pathways and the evolution of Agaricomycotina 1-13. doi.org/10.1186/s12864-015-1380-0 [0594] Silva, C. M., Borba, T. M., Burkert, C. A. V, Burkert, J. F. M., 2012. Carotenoid production by Phaffia rhodozyma using raw glycerol as an additional carbon source. Int. J. Food Eng. 8. doi.org/10.1515/1556-3758.2843 [0595] Srinivasan, S., Avadhani, N. G., 2012. Cytochrome c oxidase dysfunction in oxidative stress. Free Radic. Biol. Med. doi.org/10.1016/j.freeradbiomed.2012.07.021 [0596] Sun, N., Lee, S., Song, K. Bin, 2004. Characterization of a carotenoid-hyperproducing yeast mutant isolated by low-dose gamma irradiation. Int. J. Food Microbiol. 94, 263-267. doi.org/10.1016/50168-1605(03)00311-8 [0597] Thorvaldsdttir, H., Robinson, J. T., Mesirov, J. P., 2013. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform. 14, 178-92. doi.org/10.1093/bib/bbs017 [0598] Trapnell, C., Roberts, A., Goff, L., Pertea, G., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., Pachter, L., 2012. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat. Protoc. 7, 562-78. doi.org/10.1038/nprot.2012.016 [0599] Ukibe, K., Katsuragi, T., Tani, Y., Takagi, H., 2008. Efficient screening for astaxanthin-overproducing mutants of the yeast Xanthophyllomyces dendrorhous by flow cytometry. FEMS Microbiol. Lett. 286, 241-248. doi.org/10.1111/j.1574-6968.2008.01278.x [0600] Verdoes, J. C., Krubasik, P., Sandmann, G., Van Ooyen, A. J. J., 1999. Isolation and functional characterisation of a novel type of carotenoid biosynthetic gene from Xanthophyllomyces dendrorhous. Mol. Gen. Genet. 262, 453-461. doi.org/10.1007/s004380051105 [0601] Xie, H., Zhou, Y., Hu, J., Chen, Y., Liang, J., 2014. Production of astaxanthin by a mutant strain of Phaffia rhodozyma and optimization of culture conditions using response surface methodology. Ann. Microbiol. 64, 1473-1481. doi.org/10.1007/s13213-013-0790-y [0602] Yeo, K. Y. B., Chrysanthopoulos, P. K., Nouwens, A. S., Marcellin, E., and Schulz, B. L. (2016) High performance targeted mass spectrometry with precision data independent acquisition reveals site-specific glycosylation macroheterogeneity. Anal Biochem 510: 106-113. [0603] Yin, Z., Stead, D., Walker, J., Selway, L., Smith, D. A., Brown, A. J. P., Quinn, J., 2009. A proteomic analysis of the salt, cadmium and peroxide stress responses in Candida albicans and the role of the HogI stress-activated MAPK in regulating the stress-induced proteome. Proteomics 9, 4686-4703. doi.org/10.1002/pmic.200800958 [0604] Zerbino, D. R., 2010. Using the Velvet de novo assembler for short-read sequencing technologies.
[0605] Curr. Protoc. Bioinformatics Chapter 11, Unit 11.5. doi.org/10.1002/0471250953.bi1105s31 [0606] Zhang, C., Chen, X., Too, H. P., 2020. Microbial astaxanthin biosynthesis: recent achievements, challenges, and commercialization outlook. Appl. Microbiol. Biotechnol. doi.org/10.1007/s00253-020-10648-2 [0607] Zhang, L., Chen, W., Yang, S., Zhang, Y., Xu, J., Yang, D., Wu, Z., Liu, T., Cao, J., 2020. Identification and Functional Characterization of a Novel 12 Fatty Acid Desaturase Gene from Haematococcus pluvialis. J. Ocean Univ. China 19, 1362-1370. doi.org/10.1007/s11802-020-4418-0 [0608] Zhang, Y., Navarro, E., Cnovas-Mrquez, J. T., Almagro, L., Chen, H., Chen, Y. Q., Zhang, H., Torres-Martinez, S., Chen, W., Garre, V., 2016. A new regulatory mechanism controlling carotenogenesis in the fungus Mucor circinelloides as a target to generate -carotene over-producing strains by genetic engineering. Microb. Cell Fact. 15. doi.org/10.1186/s12934-016-0493-8
[0609] The disclosure of each patent and scientific document, computer program and algorithm referred to in this specification is incorporated by reference in its entirety.
[0610] Throughout the specification, the aim has been to describe typical aspects and embodiments without limiting the invention as disclosed herein to any one aspect, embodiment, or specific collection of features. It will be appreciated that various changes and modifications may be made relative to the exemplary disclosure provided herein without departing from the present invention.
[0611] In this specification, the use of the terms suitable and suitably, and similar terms, is not to be read as implying that a feature or step is essential, although such features or steps referred to as suitable may well be preferred.
[0612] In this specification, the indefinite articles a and an are not to be read as singular indefinite articles or as otherwise excluding more than one or more than a single subject to which the indefinite article refers. For example, a cell includes one cell, one or more cells, and a plurality of cells.
[0613] In this specification, the terms comprises, comprising, includes, including, and similar terms, are intended to denote the inclusion of a stated integer or integers, but not necessarily the exclusion of another integer or other integers, depending on context. That is, a product, composition, or method, etc., that comprises or includes stated integer(s) need not have those integer(s) solely, and may well have at least some other integers not stated, depending on context.
[0614] In this specification, the terms consisting essentially of and consists essentially of are intended to mean a non-exclusive inclusion only to the extent that, if additional elements are included beyond those elements recited, the additional elements do not materially alter basic and novel characteristics. That is, a composition, apparatus, system, or method that consists essentially of one or more recited elements includes those elements only, or those elements and any additional elements that do not materially alter the basic and novel characteristics of the apparatus, system, or method.
Tables
Table Descriptions
[0615] Table 1. Kinetic model parameters as per Example 1.
[0616] Table 2. Nitrogen sources assessed in relation to growth and carotenoid production as per Example 1.
[0617] Table 3. Carbon sources assessed in relation to growth and carotenoid production as per Example 1.
[0618] Table 4. Genomic characteristics of X. dendrorhous strains (referred to as P. rhodozyma in Table 4) sequenced as per Example 1.
[0619] Tables 5-7. Analyses of variance of the factorial design as per Example 1 to evaluate the effect on carotenoid production of the culture media components: Bactopeptone (BP), Malt Extract (ME), Yeast Extract (YE), Sucrose, Dried Corn Steep Liquor (DCSL), Vitamins Cocktail, and Potassium Phosphate Monobasic (KH.sub.2PO.sub.4).
[0620] Table 8. Coefficients of the quadratic equation and model validation as per Example 1.
[0621] Table 9. Fermentation parameters of wild-type (CBS6938) and mutant (BPAX-A1) X. dendrorhous strains as per Example 2.
[0622] Table 10. Kinetic parameters of fermentation with wild-type (CBS6938) and mutant strains (BPAX-A1) of X. dendrorhous as per Example 2.
[0623] Table 11. Amino acid profile analysis for formulations as described in Example 3.
[0624] Table 12. Variants in re-sequenced X. dendrorhous CBS 6938 and eight mutant X. dendrorhous strains (MAMY3, MAMY6, MB18, MB24, MYM0, MYM6, MYM44, and MYM92) as per Example 1, relative to SEQ ID NOs:12685-12950. V=variation index; S=strain, wherein WT=re-sequenced CBS 6938, M1=MAMY3, M2=MAMY6, M3=MB18, M4=MB24, M5=MYM0, M6=MYM6, M7=MYM44, M8=MYM92); RS=reference scaffold in published genome assembly of Sharma et al. BMC genomics 16.1 (2015): 1-13, corresponding to SEQ ID NOs:12685-12950, wherein the scaffold number is given, i.e. 62 corresponds to scaffold_62 as per the published assemblythe correspondence of SEQ ID NOs:12685-12950 to the reference scaffolds in the published genome assembly will be apparent or readily determinable by the skilled person; RB=reference scaffold base at the variation position; SB=strain base at the variation position; T=type of change of the variation, wherein 1=synonymous, 2=missense, 3=upstream region of a CDS, 4=downstream region of a CDS, 5=stop gained, 6=intergenic; 7=intron variant, 8=splice variant, 9=start lost; CDS=coding sequence reference for affected CDS (if applicable) as per the published genome assembly of Sharma et al. BMC genomic 16.1 (2015): 1-13, corresponding to SEQ ID NOs:12951-19331the correspondence of SEQ ID NOs:12951-19331 to the CDS reference in the published genome assembly will be apparent or readily determinable by the skilled person.
[0625] Table 13. Variations (a subset of those in Table 12) shared across all eight sequenced mutant strains X. dendrorhous strains (MAMY3, MAMY6, MB18, MB24, MYM0, MYM6, MYM44, and MYM92) and not present in re-sequenced X. dendrorhous CBS 6938 as per Example 1, relative to SEQ ID NOs:12685-12950. V, RS, RP, RB, SB, T, and CDS are as per Table 12. GC=gene characterisation; AA change=amino acid change of the variation, as applicable.
[0626] Table 14. Twenty-five selected variations (Z.sub.1 to Z.sub.25; a subset of those in Table 13) considered of particular interest as per Example 1.
[0627] Table 15. Twenty-six selected variations (V.sub.1 to V.sub.26; a subset of those in Table 13) considered of particular interest as per Example 2.
[0628] Table 16. CDS transcripts differentially expressed between BPAX-A1 (MYM0) mutant X. dendrorhous strain and wild-type X. dendrorhous CBS 6938 as per Example 2.
[0629] Table 17. Differential expression analysis between BPAX-A1 (MYM0) mutant X. dendrorhous strain and wild-type X. dendrorhous CBS 6938 for selected CDS transcripts (Ti to T.sub.55) considered of particular interest.
[0630] Table 18. CDS sequences encoding proteins differentially expressed between BPAX-A1 (MYM0) mutant X. dendrorhous strain and wild-type X. dendrorhous CBS 6938 at Growth Phase 3, as per Example 3.
[0631] Table 19. CDS sequences encoding proteins differentially expressed between BPAX-A1 (MYM0) mutant X. dendrorhous strain and wild-type X. dendrorhous CBS 6938 at Growth Phase 4, as per Example 3.
[0632] Table 20. CDS accessions of X. dendrorhous CBS 6938 (as published by Sharma et al. BMC genomics 16.1 (2015): 1-13 and deposited at the European Nucleotide Archive; www.ebi.ac.uk/ena/browser/home) containing variations as set out in Table 14 and Table 15, and corresponding SEQ ID NOs.
Tables 1-20 Follow
TABLE-US-00001 TABLE 1 Parameter Unit Value max h.sup.1 0.12 Ks g/L 2.33 Yxs g/g 0.7 g/gDCW *2000-4000 rho 1 kp g 650,000 g/h 50 ms g/gDCW .Math. h 0.005 *Low Range: Growth Phase; High Range: Production Phase
TABLE-US-00002 TABLE 2 Nitrogen Source A.sub.600 Carotenoids (g/L) Ypx (g/gDCW) Urea 18.6 0.23 10511.63 394.66 1339.23 50.28 Ammonium 21.76 0.12 26186.05 2565.32 2848.84 197.90 Sulphate YE 20.46 0.31 41860.47 1578.66 4850.21 256.59 ME 9.08 0.56 20186.05 920.88 5285.83 569.63 BP 20.42 0.82 38046.51 1578.66 4422.41 360.84 DCSL 18.80 0.46 29860.47 2104.88 3768.083 356.02 YE yeast extract; ME malt extract; BP bactopeptone; DCSL dried corn steep liquor; Ypx yield of carotenoid produced per gram of dried cell weight.
TABLE-US-00003 TABLE 3 Carbon Source A.sub.600 Final pH Carotenoids (ug/L) Ypx (g/g) Molasses 19.79 0.12 5.39 0.01 39906.98 789.32 4778.89 125.5 Glucose 26.00 1.27 5.26 0.01 37348.84 2039.01 3132.13 749.62 Glycerol.sup.1 27.89 6.8 5.11 0.01 53395.35 1183.99 4688 1244.11 Sucrose 26.55 2.12 5.23 0.06 36046.51 2696.87 3217.91 16.40 .sup.1Lag phase extended for three days
TABLE-US-00004 TABLE 4 Genome Size No. of Strain (Mb) contigs % GC N50 P. rhodozyma CBS6938.sup.1 19.50 266 47.31 2,080,000 P. rhodozyma CBS6938_Y8.sup.2 19.05 1239 48.31 39,444 P. rhodozyma MYM6_Y2 19.01 1254 48.51 37,281 P. rhodozyma MYM0_Y11 19.01 1136 48.61 42,199 P. rhodozyma MYM44_Y14 18.92 1722 48.72 23,350 P. rhodozyma MB18_Y15 19.01 1140 48.64 44,235 P. rhodozyma MAMY3_Y16 18.88 1556 48.64 28,341 P. rhodozyma MB24_Y17 19.11 1421 48.73 30,813 P. rhodozyma MYM92_Y4 18.96 1651 48.76 23,938 P. rhodozyma MAMY6_Y12 18.55 1565 48.27 23,723 .sup.1Phaffia rhodozyma CBS 6938 downloaded from ENA: LN483084-LN483350 (Sharma et al., 2015). .sup.2Phaffia rhodozyma CBS 6938 re- sequenced in this study. % GC, guanine-cytosine percentage content.
TABLE-US-00005 TABLE 5 Source DF Adj SS Adj MS F-Value P-Value Model 7 1445027042 206432435 112.30 0.000 Linear 7 1445027042 206432435 112.30 0.000 BP 1 8450514 8450514 4.60 0.064 ME 1 109032450 109032450 59.31 0.000 YE 1 14018929 14018929 7.63 0.025 Sucrose 1 1284305571 1284305571 698.64 0.000 DCSL 1 22287182 22287182 12.12 0.008 Vitamins Cocktail 1 6905895 6905895 3.76 0.089 KH2PO4 1 26501 26501 0.01 0.907 Error 8 14706328 1838291 Total 15 1459733369 R.sup.2 = 98.11%
TABLE-US-00006 TABLE 6 Source DF Adj SS Adj MS F-Value P-Value Model 7 38.3215 5.4745 49.73 0.000 Linear 7 38.3215 5.4745 49.73 0.000 BP 1 0.4390 0.4390 3.99 0.081 ME 1 1.7224 1.7224 15.65 0.004 YE 1 0.0579 0.0579 0.53 0.489 Sucrose 1 35.7573 35.7573 324.85 0.000 DCSL 1 0.1411 0.1411 1.28 0.290 Vitamins Cocktail 1 0.0752 0.0752 0.68 0.432 KH2PO4 1 0.1287 0.1287 1.17 0.311 Error 8 0.8806 0.1101 Total 15 39.2021 R.sup.2 = 97.75%
TABLE-US-00007 TABLE 7 Source DF Adj SS Adj MS F-Value P-Value Model 7 2009531 287076 13.55 0.001 Linear 7 2009531 287076 13.55 0.001 BP 1 151052 151052 7.13 0.028 ME 1 174941 174941 8.26 0.021 YE 1 151802 151802 7.16 0.028 Sucrose 1 1187459 1187459 56.05 0.000 DCSL 1 303517 303517 14.33 0.005 Vitamins Cocktail 1 35727 35727 1.69 0.230 KH2PO4 1 5032 5032 0.24 0.639 Error 8 169496 21187 Total 15 2179026 R.sup.2 = 92.22%
TABLE-US-00008 TABLE 8 initial sucrose Carotenoid Carotenoid concentration production (ug/L) production (ug/L) (g/L) Predicted Calculated 10 35,849 44,418 15 48,217 51,162 25 74,793 73,953 40 118,636 111,860 80 165,546 145,348 Coded Coefficient Value P-Value Constant 91529 0.000 ME 4175 0.447 Sucrose 31769 0.000 DCSL 7620 0.191 YE 2882 0.597 ME*ME 4079 0.696 Sucrose*Sucrose 12521 0.241 DCSL*DCSL 5591 0.579 YE*YE 6335 0.545 ME*Sucrose 3805 0.783 ME*DCSL 5520 0.684 ME*YE 6234 0.653 Sucrose*DCSL 14251 0.302 Sucrose*YE 10433 0.454 DCSL*YE 524 0.969
TABLE-US-00009 TABLE 9 Biomass Carotenoids Astaxanthin Ypx Ypax Yxs Strain (gDCW/L) (g/L) (g/L) (g/gDCW) (g/gDCW) (gDCW/g) BPAX-A1 10.01 0.39 28310 12 21212 19 2832 207 2118 165 0.43 0.02 CBS6938 13.60 0.29 2651 61 1875 29 195 0.5 137 1.7 0.62 0.01 The parameters represent global values of the average of three biological replicates. Ypx Specific carotenoid production yield; Ypax Specific AX production yield; Yxs Biomass to sugar consumption yield. gDCW/L grams of dried cell weight per litre.
TABLE-US-00010 TABLE 10 qp qpax qs Strain (h.sup.1) (g/gDCW .Math. h) (g/gDCW .Math. h) (g/gDCW .Math. h) BPAX-A1-Phase 1 0.11 0.002 80.70 16.39 50.25 4.46 0.13 0.33 BPAX-A1-Phase 2 0.10 0.005 197.37 15.62 67.01 17.93 0.22 0.01 BPAX-A1-Phase 3 0.10 0.004 141.89 27.55 60.58 2.19 0.21 0.03 BPAX-A1-Phase 4 0.0 0.000 83.60 1.15 33.37 7.79 0.0 0.00 CBS6938-Phase 1 0.12 0.002 2.14 0.05 1.27 0.50 0.18 0.03 CBS6938-Phase 2 0.12 0.004 16.97 0.20 3.02 1.41 0.25 0.02 CBS6938-Phase 3 0.10 0.004 16.36 0.27 9.55 2.43 0.19 0.01 CBS6938-Phase 4 0.0 0.000 3.90 0.13 4.03 2.55 0.0 0.00 : Specific growth rate; qp: Specific carotenoids production; qax: Specific astaxanthin production; qs: Specific glucose consumption
TABLE-US-00011 TABLE 11 Amino Acid uM/gDCW SSD Arginine 22.23377 1.296117 Histidine 0.679908 0.115273 Threonine 3.79767 0.511533 Glutamine/Lysine 34.24658 3.448584 Lysine/Glutamine 1.051276 0.149964 Valine 2.577432 0.475985 Methionine 0.266643 0.025636 Isoleucine 0.460132 0.080446 Leucine 0.460132 0.080446 Phenylalanine 0.612914 0.118322 Tryptophan 0.049219 0.006615 L-Tyrosine 0.141318 0.019971 Proline 0.262457 0.039893 Serine 4.693926 0.556659 Aspartic acid 21.66696 1.089912 Glutamic acid 57.78015 6.399202 Glycine 0.699527 0.138553 Asparagine 7.194973 0.968078 Alanine 5.183911 1.019159
TABLE-US-00012 TABLE 12 V S RS RP RB SB T CDS X.sub.1 WT 62 26 T A 4 CDZ96152 X.sub.2 WT 62 27 T C 4 CDZ96152 X.sub.3 WT 62 55 T A 4 CDZ96152 X.sub.4 WT 179 2648 A G 4 CDZ96154 X.sub.5 WT 179 2649 G A 4 CDZ96154 X.sub.6 WT 24 513 T C 3 CDZ96160 X.sub.7 WT 24 520 C G 3 CDZ96160 X.sub.8 WT 24 242334 A T 5 CDZ96235 X.sub.9 WT 33 399 T A 4 CED82002 X.sub.10 WT 33 4019 T C 4 CED82002 X.sub.11 WT 33 370630 A T 6 CED82121- CED82122 X.sub.12 WT 33 374131 A G 6 CED82121- CED82122 X.sub.13 WT 33 374134 A G 6 CED82121- CED82122 X.sub.14 WT 33 374137 A T 6 CED82121- CED82122 X.sub.15 WT 33 374150 A C 6 CED82121- CED82122 X.sub.16 WT 33 375339 A G 6 CED82121- CED82122 X.sub.17 WT 33 375366 T C 6 CED82121- CED82122 X.sub.18 WT 33 385319 A C 2 CED82122 X.sub.19 WT 33 385527 C T 2 CED82122 X.sub.20 WT 33 917545 A G 7 CED82294 X.sub.21 WT 33 917558 G A 7 CED82294 X.sub.22 WT 33 917771 A T 7 CED82294 X.sub.23 WT 33 928726 C T 3 CED82295 X.sub.24 WT 33 936350 T A 3 CED82300 X.sub.25 WT 33 936356 G A 3 CED82300 X.sub.26 WT 33 936571 A G 3 CED82300 X.sub.27 WT 33 936600 G A 3 CED82300 X.sub.28 WT 33 936667 A G 3 CED82300 X.sub.29 WT 33 1538001 G A 3 CED82483 X.sub.30 WT 33 1544767 A C 6 CED82485- CED82486 X.sub.31 WT 48 563 C T 6 X.sub.32 WT 48 565 T C 6 X.sub.33 WT 48 576 G A 6 X.sub.34 WT 48 580 T A 6 X.sub.35 WT 48 720 A G 6 X.sub.36 WT 52 516267 C T 3 CED82823 X.sub.37 WT 52 1313179 A G 3 CED83105 X.sub.38 WT 52 1506995 T C 2 CED83177 X.sub.39 WT 52 1874150 G T 3 CED83305 X.sub.40 WT 52 2575090 A G 3 CED83525 X.sub.41 WT 54 4815 G A 1 CDZ96384 X.sub.42 WT 54 4816 A T 2 CDZ96384 X.sub.43 WT 54 4817 G C 2 CDZ96384 X.sub.44 WT 54 4821 G A 1 CDZ96384 X.sub.45 WT 54 274617 A T 3 CDZ96471 X.sub.46 WT 54 316790 T G 4 CDZ96487 X.sub.47 WT 54 468399 T A 3 CDZ96530 X.sub.48 WT 54 616268 A G 3 CDZ96581 X.sub.49 WT 58 93 T C 6 X.sub.50 WT 69 82710 G A 3 CED83554 X.sub.51 WT 69 1084824 G A 3 CED83891 X.sub.52 WT 69 1084835 C T 3 CED83891 X.sub.53 WT 69 1084848 A G 3 CED83891 X.sub.54 WT 69 1084866 A G 3 CED83891 X.sub.55 WT 69 1084931 C T 3 CED83891 X.sub.56 WT 69 1109785 C T 3 CED83899 X.sub.57 WT 69 1109813 A G 3 CED83899 X.sub.58 WT 69 1109818 A G 3 CED83899 X.sub.59 WT 69 1109819 T A 3 CED83899 X.sub.60 WT 69 1109823 T C 3 CED83899 X.sub.61 WT 69 1109830 A G 3 CED83899 X.sub.62 WT 69 1109831 C A 3 CED83899 X.sub.63 WT 69 1109835 A G 3 CED83899 X.sub.64 WT 69 1257466 A G 2 CED83949 X.sub.65 WT 69 2089848 A G 4 CED84232 X.sub.66 WT 69 2089870 C T 4 CED84232 X.sub.67 WT 69 2089876 C A 4 CED84232 X.sub.68 WT 69 2099452 C G 4 CED84233 X.sub.69 WT 72 93 T C 6 X.sub.70 WT 77 18912 A G 2 CDZ96635 X.sub.71 WT 77 34978 G T 3 CDZ96642 X.sub.72 WT 77 39665 G C 2 CDZ96646 X.sub.73 WT 77 39842 G A 8 CDZ96646 X.sub.74 WT 78 263674 A G 3 CED84438 X.sub.75 WT 78 263828 T C 3 CED84438 X.sub.76 WT 78 263896 T C 3 CED84438 X.sub.77 WT 78 280587 G A 2 CED84440 X.sub.78 WT 78 280603 A G 1 CED84440 X.sub.79 WT 78 281454 C A 3 CED84441 X.sub.80 WT 78 298141 C G 3 CED84443 X.sub.81 WT 78 301815 T C 3 CED84443 X.sub.82 WT 78 302700 A G 2 CED84443 X.sub.83 WT 78 333312 A G 3 CED84452 X.sub.84 WT 78 661166 G C 2 CED84562 X.sub.85 WT 78 1143063 A G 3 CED84728 X.sub.86 WT 78 1742796 G A 3 CED84926 X.sub.87 WT 79 161 T C 3 CDZ96674 X.sub.88 WT 79 687842 T C 2 CDZ96908 X.sub.89 WT 79 735053 T C 3 CDZ96928 X.sub.90 WT 79 748083 G T 3 CDZ96929 X.sub.91 WT 79 759403 C T 3 CDZ96931 X.sub.92 WT 79 759659 G A 2 CDZ96931 X.sub.93 WT 79 760430 T C 2 CDZ96932 X.sub.94 WT 79 760541 A G 2 CDZ96932 X.sub.95 WT 79 760891 A G 2 CDZ96932 X.sub.96 WT 79 760988 G T 2 CDZ96932 X.sub.97 WT 79 761056 T C 3 CDZ96932 X.sub.98 WT 79 768537 A G 4 CDZ96933 X.sub.99 WT 79 786064 A G 3 CDZ96934 X.sub.100 WT 79 830852 T A 2 CDZ96950 X.sub.101 WT 79 1287496 C T 1 CDZ97107 X.sub.102 WT 79 2339881 C G 3 CDZ97460 X.sub.103 WT 79 2340326 G A 3 CDZ97462 X.sub.104 WT 79 2340636 T C 3 CDZ97462 X.sub.105 WT 81 210 G T 6 X.sub.106 WT 85 521 C T 6 X.sub.107 WT 85 522 A G 6 X.sub.108 WT 105 130 T A 2 CDZ97474 X.sub.109 WT 105 429 C T 4 CDZ97474 X.sub.110 WT 121 784 A G 6 X.sub.111 WT 121 1269 A T 6 X.sub.112 WT 121 1402 C G 6 X.sub.113 WT 138 123 G T 6 X.sub.114 WT 138 651 T A 6 X.sub.115 WT 138 657 A C 6 X.sub.116 WT 149 1163 T C 8 CDZ97597 X.sub.117 WT 149 2074 T G 3 CDZ97598 X.sub.118 WT 159 106 A C 6 X.sub.119 WT 162 68192 C G 2 CDZ97625 X.sub.120 WT 162 70405 A G 1 CDZ97625 X.sub.121 WT 162 308369 T C 1 CDZ97702 X.sub.122 WT 162 311666 A G 4 CDZ97702 X.sub.123 WT 162 320785 G C 4 CDZ97703 X.sub.124 WT 162 320786 T G 4 CDZ97703 X.sub.125 WT 162 321460 C G 4 CDZ97703 X.sub.126 WT 162 321463 A C 4 CDZ97703 X.sub.127 WT 162 322591 G A 4 CDZ97703 X.sub.128 WT 162 323448 T G 2 CDZ97703 X.sub.129 WT 162 323451 T G 2 CDZ97703 X.sub.130 WT 162 323735 A G 1 CDZ97703 X.sub.131 WT 162 324114 T C 2 CDZ97703 X.sub.132 WT 162 324139 C T 2 CDZ97703 X.sub.133 WT 162 324568 A G 2 CDZ97703 X.sub.134 WT 162 492101 G A 3 CDZ97764 X.sub.135 WT 162 622253 A C 1 CDZ97809 X.sub.136 WT 162 738675 G A 3 CDZ97842 X.sub.137 WT 162 738686 C T 3 CDZ97842 X.sub.138 WT 189 69196 T A 3 CDZ97980 X.sub.139 WT 189 194647 A G 3 CDZ98020 X.sub.140 WT 189 194665 A G 3 CDZ98020 X.sub.141 WT 191 342 A G 3 CDZ98107 X.sub.142 WT 191 347 C T 3 CDZ98107 X.sub.143 WT 191 427 C T 3 CDZ98107 X.sub.144 WT 191 451 C T 3 CDZ98107 X.sub.145 WT 191 487 A G 3 CDZ98107 X.sub.146 WT 198 202 C A 6 X.sub.147 WT 198 203 G A 6 X.sub.148 WT 206 406 G A 6 X.sub.149 WT 220 116 C G 6 X.sub.150 WT 223 93 G A 4 CDZ98118 X.sub.151 WT 223 102 A G 4 CDZ98118 X.sub.152 WT 223 133 A G 4 CDZ98118 X.sub.153 WT 223 150 T C 4 CDZ98118 X.sub.154 WT 223 155 A C 4 CDZ98118 X.sub.155 WT 223 158 T C 4 CDZ98118 X.sub.156 WT 223 160 C T 4 CDZ98118 X.sub.157 WT 223 175 G A 4 CDZ98118 X.sub.158 WT 223 177 A G 4 CDZ98118 X.sub.159 WT 223 188 A G 4 CDZ98118 X.sub.160 WT 223 192 C A 4 CDZ98118 X.sub.161 WT 223 194 T C 4 CDZ98118 X.sub.162 WT 223 195 T G 4 CDZ98118 X.sub.163 WT 223 197 T C 4 CDZ98118 X.sub.164 WT 229 225 G C 6 X.sub.165 WT 235 3161 A G 6 X.sub.166 WT 249 206 G A 4 CED84929 X.sub.167 WT 249 29505 T G 3 CED84937 X.sub.168 WT 249 41573 G A 3 CED84940 X.sub.169 WT 249 107121 A G 3 CED84966 X.sub.170 WT 249 501510 T C 3 CED85093 X.sub.171 WT 249 969333 G T 3 CED85238 X.sub.172 WT 249 1195367 G A 3 CED85307 X.sub.173 WT 249 1498029 T C 3 CED85415 X.sub.174 WT 249 1498823 T C 2 CED85414 X.sub.175 WT 249 1498829 C T 2 CED85414 X.sub.176 WT 249 1499008 A G 3 CED85415 X.sub.177 WT 249 1502631 G T 2 CED85416 X.sub.178 WT 249 1502641 T A 2 CED85416 X.sub.179 WT 249 1502819 T G 1 CED85416 X.sub.180 WT 249 1505138 G A 3 CED85416 X.sub.181 WT 249 1505634 T G 3 CED85416 X.sub.182 WT 249 1518591 T A 3 CED85419 X.sub.183 WT 249 1519431 A G 3 CED85419 X.sub.184 WT 249 1653615 T G 2 CED85457 X.sub.185 WT 249 1653962 C T 4 CED85458 X.sub.186 WT 249 1679374 A G 3 CED85461 X.sub.187 WT 249 1679375 A T 3 CED85461 X.sub.188 WT 249 1780551 A G 3 CED85493 X.sub.189 WT 249 1780569 A G 3 CED85493 X.sub.190 WT 249 1801965 G A 3 CED85501 X.sub.191 WT 249 2255547 G C 3 CED85640 X.sub.192 WT 258 166 A G 6 X.sub.193 WT 258 576 A G 6 X.sub.194 WT 258 1139 A T 6 X.sub.195 WT 262 4049 G A 1 CDZ98330 X.sub.196 WT 262 136093 A T 1 CDZ98374 X.sub.197 WT 262 539428 G A 3 CDZ98514 X.sub.198 WT 262 539452 A G 3 CDZ98514 X.sub.199 WT 262 539470 A G 3 CDZ98514 X.sub.200 WT 262 628911 G C 3 CDZ98543 X.sub.201 WT 262 638804 G C 3 CDZ98544 X.sub.202 WT 262 638986 C G 3 CDZ98544 X.sub.203 WT 262 641218 G C 4 CDZ98544 X.sub.204 WT 262 653920 A G 4 CDZ98545 X.sub.205 WT 262 655754 A T 4 CDZ98545 X.sub.206 WT 262 655757 T C 4 CDZ98545 X.sub.207 WT 262 941629 C T 1 CDZ98638 X.sub.208 WT 262 1329643 C T 3 CDZ98760 X.sub.209 WT 262 1678838 C A 2 CDZ98874 X.sub.210 WT 262 1716385 G A 3 CDZ98887 X.sub.211 WT 267 93 G A 6 X.sub.212 WT 267 94 A G 6 X.sub.213 WT 267 133 T C 6 X.sub.214 WT 267 134 C T 6 X.sub.215 WT 267 201 T C 6 X.sub.216 WT 267 208 T C 6 X.sub.217 WT 267 233 A G 6 X.sub.218 WT 267 234 A C 6 X.sub.219 WT 267 237 A G 6 X.sub.220 WT 267 254 G T 6 X.sub.221 WT 267 256 A G 6 X.sub.222 WT 267 257 T C 6 X.sub.223 M1 22 1643 C T 2 CED80056 X.sub.224 M1 22 2524 G A 4 CED80056 X.sub.225 M1 28 236 G A 3 CDZ96150 X.sub.226 M1 28 377 G A 3 CDZ96150 X.sub.227 M1 28 1506 C T 2 CDZ96150 X.sub.228 M1 28 1677 C T 4 CDZ96150 X.sub.229 M1 43 464 G A 2 CDZ96151 X.sub.230 M1 43 753 C T 2 CDZ96151 X.sub.231 M1 43 757 G A 1 CDZ96151 X.sub.232 M1 43 1527 C T 3 CDZ96151 X.sub.233 M1 43 1748 G A 3 CDZ96151 X.sub.234 M1 43 1928 C T 3 CDZ96151 X.sub.235 M1 62 26 T A 4 CDZ96152 X.sub.236 M1 62 27 T C 4 CDZ96152 X.sub.237 M1 62 55 T A 4 CDZ96152 X.sub.238 M1 62 403 C T 1 CDZ96152 X.sub.239 M1 62 875 G A 2 CDZ96152 X.sub.240 M1 102 339 C T 4 CDZ96153 X.sub.241 M1 102 951 G A 4 CDZ96153 X.sub.242 M1 102 1042 G A 4 CDZ96153 X.sub.243 M1 102 2334 G A 2 CDZ96153 X.sub.244 M1 102 2590 C T 2 CDZ96153 X.sub.245 M1 102 3427 C T 3 CDZ96153 X.sub.246 M1 176 358 G A 3 CED80058 X.sub.247 M1 176 1872 G A 4 CED80058 X.sub.248 M1 176 1980 G A 4 CED80058 X.sub.249 M1 179 93 A G 3 CDZ96154 X.sub.250 M1 179 96 G A 3 CDZ96154 X.sub.251 M1 179 1525 G A 7 CDZ96154 X.sub.252 M1 179 1780 C T 7 CDZ96154 X.sub.253 M1 188 815 C T 2 CED80060 X.sub.254 M1 188 1174 C T 4 CED80060 X.sub.255 M1 188 2163 G A 4 CED80060 X.sub.256 M1 188 2170 G A 4 CED80060 X.sub.257 M1 247 102 G A 4 CED80061 X.sub.258 M1 247 989 C T 2 CED80061 X.sub.259 M1 247 1053 G A 2 CED80061 X.sub.260 M1 7 160 T C 6 X.sub.261 M1 8 1110 C T 6 X.sub.262 M1 11 154 A C 6 X.sub.263 M1 11 158 C T 6 X.sub.264 M1 13 131 G C 3 CDZ96158 X.sub.265 M1 15 134 G A 6 X.sub.266 M1 15 135 T C 6 X.sub.267 M1 15 139 G C 6 X.sub.268 M1 15 148 G C 6 X.sub.269 M1 15 149 A G 6 X.sub.270 M1 15 165 G T 6 X.sub.271 M1 15 184 C T 6 X.sub.272 M1 15 205 C G 6 X.sub.273 M1 15 214 G C 6 X.sub.274 M1 15 248 G A 6 X.sub.275 M1 15 249 C G 6 X.sub.276 M1 15 252 C T 6 X.sub.277 M1 15 254 A G 6 X.sub.278 M1 15 256 T C 6 X.sub.279 M1 15 327 T G 6 X.sub.280 M1 24 513 T C 3 CDZ96160 X.sub.281 M1 24 520 C G 3 CDZ96160 X.sub.282 M1 24 5850 C T 2 CDZ96160 X.sub.283 M1 24 68660 C T 3 CDZ96181 X.sub.284 M1 24 118860 C T 2 CDZ96200 X.sub.285 M1 24 168850 C T 1 CDZ96214 X.sub.286 M1 24 180340 G A 3 CDZ96216 X.sub.287 M1 24 197593 C T 2 CDZ96224 X.sub.288 M1 24 266697 G A 1 CDZ96242 X.sub.289 M1 24 278319 G A 3 CDZ96245 X.sub.290 M1 24 289183 T C 3 CDZ96250 X.sub.291 M1 24 307114 G A 2 CDZ96255 X.sub.292 M1 24 340663 T C 3 CDZ96265 X.sub.293 M1 24 340866 G A 3 CDZ96265 X.sub.294 M1 24 363770 C T 2 CDZ96275 X.sub.295 M1 24 382911 C T 2 CDZ96282 X.sub.296 M1 24 400418 C T 2 CDZ96287 X.sub.297 M1 24 420108 G A 3 CDZ96291 X.sub.298 M1 24 474698 G A 2 CDZ96308 X.sub.299 M1 26 245 G A 6 X.sub.300 M1 27 445 C T 6 X.sub.301 M1 27 1012 A C 6 X.sub.302 M1 27 1013 T A 6 X.sub.303 M1 32 158 C T 3 CDZ96332 X.sub.304 M1 32 215 C T 3 CDZ96332 X.sub.305 M1 32 2438 C T 3 CDZ96332 X.sub.306 M1 32 2734 C T 1 CDZ96332 X.sub.307 M1 32 2821 C T 7 CDZ96332 X.sub.308 M1 32 3067 C T 2 CDZ96332 X.sub.309 M1 32 3506 C T 4 CDZ96332 X.sub.310 M1 32 3562 G A 4 CDZ96332 X.sub.311 M1 33 399 T A 4 CED82002 X.sub.312 M1 33 24784 C T 2 CED82008 X.sub.313 M1 33 45488 C T 3 CED82012 X.sub.314 M1 33 64676 G A 3 CED82019 X.sub.315 M1 33 79913 G A 1 CED82024 X.sub.316 M1 33 105276 G A 2 CED82036 X.sub.317 M1 33 109397 G A 2 CED82038 X.sub.318 M1 33 219700 C T 2 CED82074 X.sub.319 M1 33 236149 C T 2 CED82078 X.sub.320 M1 33 257786 C T 1 CED82084 X.sub.321 M1 33 260027 G A 3 CED82084 X.sub.322 M1 33 274627 G A 8 CED82091 X.sub.323 M1 33 276128 C T 2 CED82092 X.sub.324 M1 33 283808 C T 2 CED82093 X.sub.325 M1 33 304408 C T 4 CED82099 X.sub.326 M1 33 311532 G A 3 CED82101 X.sub.327 M1 33 312032 G A 3 CED82101 X.sub.328 M1 33 317713 G A 1 CED82104 X.sub.329 M1 33 318242 G A 3 CED82105 X.sub.330 M1 33 325745 C T 2 CED82108 X.sub.331 M1 33 327840 C T 1 CED82108 X.sub.332 M1 33 341890 G A 2 CED82113 X.sub.333 M1 33 348487 C T 2 CED82115 X.sub.334 M1 33 371277 G A 6 CED82121- CED82122 X.sub.335 M1 33 374131 A G 6 CED82121- CED82122 X.sub.336 M1 33 374134 A G 6 CED82121- CED82122 X.sub.337 M1 33 374137 A T 6 CED82121- CED82122 X.sub.338 M1 33 374150 A C 6 CED82121- CED82122 X.sub.339 M1 33 375339 A G 6 CED82121- CED82122 X.sub.340 M1 33 375366 T C 6 CED82121- CED82122 X.sub.341 M1 33 382577 C T 3 CED82122 X.sub.342 M1 33 383212 G A 3 CED82122 X.sub.343 M1 33 385139 G C 2 CED82122 X.sub.344 M1 33 385155 T C 2 CED82122 X.sub.345 M1 33 385319 A C 2 CED82122 X.sub.346 M1 33 448815 G A 2 CED82144 X.sub.347 M1 33 453975 C T 2 CED82147 X.sub.348 M1 33 455451 C T 3 CED82146 X.sub.349 M1 33 509127 C T 3 CED82166 X.sub.350 M1 33 626521 C T 3 CED82203 X.sub.351 M1 33 639242 G A 2 CED82208 X.sub.352 M1 33 699423 C T 1 CED82227 X.sub.353 M1 33 774105 G A 2 CED82248 X.sub.354 M1 33 792965 G A 1 CED82256 X.sub.355 M1 33 816048 C T 3 CED82262 X.sub.356 M1 33 822184 G A 3 CED82264 X.sub.357 M1 33 917771 A T 7 CED82294 X.sub.358 M1 33 933316 C T 3 CED82299 X.sub.359 M1 33 936350 T A 3 CED82300 X.sub.360 M1 33 936356 G A 3 CED82300 X.sub.361 M1 33 936571 A G 3 CED82300 X.sub.362 M1 33 936600 G A 3 CED82300 X.sub.363 M1 33 936667 A G 3 CED82300 X.sub.364 M1 33 938992 C T 3 CED82300 X.sub.365 M1 33 1043825 C T 2 CED82333 X.sub.366 M1 33 1049699 G A 3 CED82334 X.sub.367 M1 33 1057631 G T 8 CED82339 X.sub.368 M1 33 1082006 G A 1 CED82348 X.sub.369 M1 33 1087834 G A 3 CED82350 X.sub.370 M1 33 1127676 G A 3 CED82358 X.sub.371 M1 33 1137501 G A 2 CED82362 X.sub.372 M1 33 1138444 C T 3 CED82363 X.sub.373 M1 33 1165914 G A 2 CED82372 X.sub.374 M1 33 1169025 C T 2 CED82372 X.sub.375 M1 33 1191727 C T 2 CED82379 X.sub.376 M1 33 1324395 G A 3 CED82417 X.sub.377 M1 33 1339376 C T 2 CED82424 X.sub.378 M1 33 1367015 C T 2 CED82432 X.sub.379 M1 33 1442014 G A 2 CED82456 X.sub.380 M1 33 1467702 C T 1 CED82463 X.sub.381 M1 33 1470375 C T 8 CED82465 X.sub.382 M1 33 1489288 G A 1 CED82471 X.sub.383 M1 33 1499347 G A 3 CED82472 X.sub.384 M1 33 1515148 G A 2 CED82478 X.sub.385 M1 33 1515369 G A 3 CED82478 X.sub.386 M1 33 1515652 C T 3 CED82478 X.sub.387 M1 33 1544767 A C 6 CED82486 CED82485- X.sub.388 M1 33 1544951 C G 6 CED82486 CED82485- X.sub.389 M1 33 1572498 C T 8 CED82491 X.sub.390 M1 33 1587443 C T 3 CED82497 X.sub.391 M1 33 1596242 C T 3 CED82498 X.sub.392 M1 33 1638726 G A 3 CED82513 X.sub.393 M1 33 1642659 G A 2 CED82515 X.sub.394 M1 33 1652749 C T 3 CED82516 X.sub.395 M1 33 1666106 C T 8 CED82522 X.sub.396 M1 33 1682149 C T 1 CED82526 X.sub.397 M1 33 1700000 G A 2 CED82534 X.sub.398 M1 33 1795298 G A 1 CED82562 X.sub.399 M1 33 1841263 G A 2 CED82576 X.sub.400 M1 33 1860278 G A 3 CED82582 X.sub.401 M1 33 1861675 C T 2 CED82583 X.sub.402 M1 33 1862200 G A 3 CED82582 X.sub.403 M1 33 1881896 T C 3 CED82588 X.sub.404 M1 33 1887401 C T 1 CED82591 X.sub.405 M1 33 1888706 C T 8 CED82592 X.sub.406 M1 33 1914838 C T 8 CED82602 X.sub.407 M1 33 1938614 G A 2 CED82612 X.sub.408 M1 33 1959142 G A 8 CED82619 X.sub.409 M1 33 2008504 C A 1 CED82635 X.sub.410 M1 33 2010230 C T 2 CED82636 X.sub.411 M1 33 2034962 G A 2 CED82645 X.sub.412 M1 33 2044014 G A 3 CED82647 X.sub.413 M1 33 2050847 G A 3 CED82651 X.sub.414 M1 36 320 G A 6 X.sub.415 M1 36 1056 G A 6 X.sub.416 M1 36 1295 C T 6 X.sub.417 M1 36 1461 A T 6 X.sub.418 M1 42 804 C T 4 CDZ96333 X.sub.419 M1 42 1559 G A 4 CDZ96333 X.sub.420 M1 48 405 G A 6 X.sub.421 M1 48 563 C T 6 X.sub.422 M1 48 565 T C 6 X.sub.423 M1 48 576 G A 6 X.sub.424 M1 48 580 T A 6 X.sub.425 M1 50 145 G A 6 X.sub.426 M1 52 140940 T C 4 CED82705 X.sub.427 M1 52 144382 C T 3 CED82709 X.sub.428 M1 52 150382 C T 1 CED82712 X.sub.429 M1 52 151974 C T 2 CED82712 X.sub.430 M1 52 183986 C T 8 CED82722 X.sub.431 M1 52 207354 C T 8 CED82730 X.sub.432 M1 52 284733 G A 1 CED82747 X.sub.433 M1 52 316848 C T 2 CED82758 X.sub.434 M1 52 346628 G A 2 CED82769 X.sub.435 M1 52 360279 C T 3 CED82772 X.sub.436 M1 52 390095 G A 3 CED82784 X.sub.437 M1 52 395374 G A 2 CED82786 X.sub.438 M1 52 398723 C T 3 CED82786 X.sub.439 M1 52 398728 C T 3 CED82786 X.sub.440 M1 52 516267 C T 3 CED82823 X.sub.441 M1 52 552099 G A 2 CED82837 X.sub.442 M1 52 552173 G A 1 CED82837 X.sub.443 M1 52 571124 G A 2 CED82845 X.sub.444 M1 52 595806 C T 1 CED82851 X.sub.445 M1 52 631479 C T 1 CED82860 X.sub.446 M1 52 746548 G A 1 CED82907 X.sub.447 M1 52 758326 C T 2 CED82912 X.sub.448 M1 52 817452 T A 2 CED82928 X.sub.449 M1 52 840755 C T 1 CED82935 X.sub.450 M1 52 842352 C T 3 CED82934 X.sub.451 M1 52 849671 G A 1 CED82940 X.sub.452 M1 52 928854 C T 2 CED82971 X.sub.453 M1 52 938650 G A 3 CED82973 X.sub.454 M1 52 967316 A T 2 CED82984 X.sub.455 M1 52 967701 T A 3 CED82983 X.sub.456 M1 52 970142 T C 3 CED82985 X.sub.457 M1 52 978727 C T 3 CED82988 X.sub.458 M1 52 1003899 G A 2 CED83001 X.sub.459 M1 52 1010006 C T 2 CED83002 X.sub.460 M1 52 1029498 G A 1 CED83007 X.sub.461 M1 52 1043011 C T 1 CED83012 X.sub.462 M1 52 1067895 C T 1 CED83020 X.sub.463 M1 52 1158103 C T 3 CED83051 X.sub.464 M1 52 1207168 C T 2 CED83065 X.sub.465 M1 52 1219894 C T 3 CED83071 X.sub.466 M1 52 1290031 C T 3 CED83096 X.sub.467 M1 52 1291646 C T 2 CED83098 X.sub.468 M1 52 1363357 G A 3 CED83122 X.sub.469 M1 52 1363405 C T 1 CED83123 X.sub.470 M1 52 1379155 G A 2 CED83128 X.sub.471 M1 52 1389320 G A 3 CED83130 X.sub.472 M1 52 1399439 G A 2 CED83134 X.sub.473 M1 52 1474315 G A 2 CED83164 X.sub.474 M1 52 1474412 G A 3 CED83166 X.sub.475 M1 52 1481345 G A 3 CED83165 X.sub.476 M1 52 1520883 C T 3 CED83179 X.sub.477 M1 52 1526796 G A 2 CED83181 X.sub.478 M1 52 1583655 C T 2 CED83206 X.sub.479 M1 52 1621166 C T 2 CED83219 X.sub.480 M1 52 1639254 C T 1 CED83227 X.sub.481 M1 52 1708900 A G 3 CED83249 X.sub.482 M1 52 1715136 C T 8 CED83250 X.sub.483 M1 52 1715899 C T 2 CED83250 X.sub.484 M1 52 1716210 C T 3 CED83250 X.sub.485 M1 52 1760440 G A 2 CED83266 X.sub.486 M1 52 1785354 T C 3 CED83272 X.sub.487 M1 52 1788070 G A 4 CED83273 X.sub.488 M1 52 1793370 G A 3 CED83275 X.sub.489 M1 52 1807309 G A 3 CED83283 X.sub.490 M1 52 1809897 G A 3 CED83285 X.sub.491 M1 52 1861665 C T 2 CED83301 X.sub.492 M1 52 1861681 G A 2 CED83301 X.sub.493 M1 52 1871310 C T 2 CED83304 X.sub.491 M1 52 1874150 G T 3 CED83305 X.sub.495 M1 52 1893352 G A 2 CED83313 X.sub.496 M1 52 1963875 G A 3 CED83335 X.sub.497 M1 52 1987096 G A 4 CED83341 X.sub.498 M1 52 1995167 G A 3 CED83342 X.sub.499 M1 52 2029893 G A 3 CED83351 X.sub.500 M1 52 2041781 C T 8 CED83355 X.sub.501 M1 52 2047954 G A 2 CED83358 X.sub.502 M1 52 2048018 G A 2 CED83358 X.sub.503 M1 52 2050245 G A 3 CED83359 X.sub.504 M1 52 2071127 C T 3 CED83365 X.sub.505 M1 52 2081390 G A 1 CED83367 X.sub.506 M1 52 2093148 C T 3 CED83368 X.sub.507 M1 52 2120665 C T 4 CED83376 X.sub.508 M1 52 2136885 A G 1 CED83382 X.sub.509 M1 52 2158892 C T 3 CED83392 X.sub.510 M1 52 2162878 G A 2 CED83392 X.sub.511 M1 52 2178340 G A 8 CED83397 X.sub.512 M1 52 2265219 C T 2 CED83425 X.sub.513 M1 52 2266378 C T 3 CED83423 X.sub.514 M1 52 2308421 T C 3 CED83439 X.sub.515 M1 52 2327266 C T 3 CED83445 X.sub.516 M1 52 2330881 G A 4 CED83447 X.sub.517 M1 52 2364315 G A 4 CED83455 X.sub.518 M1 52 2400778 C T 4 CED83463 X.sub.519 M1 52 2415283 C T 2 CED83469 X.sub.520 M1 52 2469433 C T 3 CED83486 X.sub.521 M1 52 2531584 C T 2 CED83507 X.sub.522 M1 52 2566106 C T 3 CED83520 X.sub.523 M1 52 2575090 A G 3 CED83525 X.sub.524 M1 53 26291 G A 2 CDZ96348 X.sub.525 M1 54 4815 G A 1 CDZ96384 X.sub.526 M1 54 4816 A T 2 CDZ96384 X.sub.527 M1 54 4817 G C 2 2CDZ96384 X.sub.528 M1 54 4821 G A 1 CDZ96384 X.sub.529 M1 54 72235 G A 2 CDZ96406 X.sub.530 M1 54 87947 G A 3 CDZ96410 X.sub.531 M1 54 106086 G A 3 CDZ96416 X.sub.532 M1 54 119439 C T 3 CDZ96420 X.sub.533 M1 54 157787 T C 1 CDZ96435 X.sub.534 M1 54 194230 G A 2 CDZ96446 X.sub.535 M1 54 202467 C T 1 CDZ96448 X.sub.536 M1 54 206494 G A 2 CDZ96450 X.sub.537 M1 54 254295 C T 2 CDZ96465 X.sub.538 M1 54 274617 A T 3 CDZ96471 X.sub.539 M1 54 357149 G A 1 CDZ96496 X.sub.540 M1 54 359671 G A 2 CDZ96496 X.sub.541 M1 54 370320 G A 2 CDZ96499 X.sub.542 M1 54 391223 A G 2 CDZ96509 X.sub.543 M1 54 410031 C A 1 CDZ96514 X.sub.544 M1 54 427542 C T 2 CDZ96520 X.sub.545 M1 54 431851 C T 3 CDZ96520 X.sub.546 M1 54 437080 G A 3 CDZ96522 X.sub.547 M1 54 478527 C T 2 CDZ96537 X.sub.548 M1 54 564688 C T 2 CDZ96566 X.sub.549 M1 54 576174 G A 2 CDZ96569 X.sub.550 M1 54 583996 G A 3 CDZ96570 X.sub.551 M1 54 616268 A G 3 CDZ96581 X.sub.552 M1 54 647579 C T 2 CDZ96590 X.sub.553 M1 54 667019 C T 4 CDZ96594 X.sub.554 M1 54 667042 C T 8 CDZ96595 X.sub.555 M1 54 733193 T C 9 CDZ96619 X.sub.556 M1 54 743396 G A 1 CDZ96621 X.sub.557 M1 58 93 T C 6 X.sub.558 M1 67 111 G A 6 X.sub.559 M1 69 29006 G A 3 CED83534 X.sub.560 M1 69 34392 G A 2 CED83536 X.sub.561 M1 69 99248 C T 2 CED83559 X.sub.562 M1 69 107920 C T 1 CED83561 X.sub.563 M1 69 201005 G A 3 CED83595 X.sub.564 M1 69 293602 G A 3 CED83626 X.sub.565 M1 69 305997 C T 2 CED83631 X.sub.566 M1 69 371916 C T 2 CED83653 X.sub.567 M1 69 415659 C T 2 CED83665 X.sub.568 M1 69 461021 C T 2 CED83680 X.sub.569 M1 69 461986 G A 1 CED83680 X.sub.570 M1 69 472563 C T 3 CED83681 X.sub.571 M1 69 482073 G T 3 CED83685 X.sub.572 M1 69 556138 C T 3 CED83710 X.sub.573 M1 69 585845 G A 2 CED83722 X.sub.574 M1 69 627928 C T 1 CED83740 X.sub.575 M1 69 631511 G A 2 CED83742 X.sub.576 M1 69 637299 T C 2 CED83744 X.sub.577 M1 69 675579 G A 3 CED83760 X.sub.578 M1 69 676581 G A 2 CED83760 X.sub.579 M1 69 676853 G A 3 CED83759 X.sub.580 M1 69 678406 C T 3 CED83759 X.sub.581 M1 69 757546 C A 2 CED83788 X.sub.582 M1 69 828676 C T 2 CED83805 X.sub.583 M1 69 857539 C T 3 CED83814 X.sub.584 M1 69 865820 C T 2 CED83814 X.sub.585 M1 69 869706 G A 8 CED83815 X.sub.586 M1 69 892199 G A 1 CED83822 X.sub.587 M1 69 894462 C T 3 CED83821 X.sub.588 M1 69 898044 C T 1 CED83823 X.sub.589 M1 69 962369 G A 3 CED83845 X.sub.590 M1 69 971219 C T 3 CED83847 X.sub.591 M1 69 988364 G A 2 CED83857 X.sub.592 M1 69 989781 G A 2 CED83858 X.sub.593 M1 69 1042212 G A 2 CED83875 X.sub.594 M1 69 1080578 G A 2 CED83890 X.sub.595 M1 69 1084824 G A 3 CED83891 X.sub.596 M1 69 1084835 C T 3 CED83891 X.sub.597 M1 69 1084848 A G 3 CED83891 X.sub.598 M1 69 1084866 A G 3 CED83891 X.sub.599 M1 69 1084931 C T 3 CED83891 X.sub.600 M1 69 1102164 C T 2 CED83897 X.sub.601 M1 69 1105560 C T 2 CED83899 X.sub.602 M1 69 1109785 C T 2 CED83899 X.sub.603 M1 69 1109813 A G 3 CED83899 X.sub.604 M1 69 1109818 A G 3 CED83899 X.sub.605 M1 69 1109819 T A 3 CED83899 X.sub.606 M1 69 1109823 T C 3 CED83899 X.sub.607 M1 69 1109830 A G 3 CED83899 X.sub.608 M1 69 1109831 C A 3 CED83899 X.sub.609 M1 69 1109835 A G 3 CED83899 X.sub.610 M1 69 1115486 C T 2 CED83902 X.sub.611 M1 69 1153118 G A 2 CED83915 X.sub.612 M1 69 1215253 G A 1 CED83936 X.sub.613 M1 69 1218409 G A 3 CED83936 X.sub.614 M1 69 1260087 G A 3 CED83949 X.sub.615 M1 69 1279557 G A 2 CED83959 X.sub.616 M1 69 1342909 G A 3 CED83975 X.sub.617 M1 69 1356844 C T 8 CED83982 X.sub.618 M1 69 1372486 C T 3 CED83987 X.sub.619 M1 69 1377243 C T 3 CED83989 X.sub.620 M1 69 1396045 G A 2 CED83994 X.sub.621 M1 69 1411237 C T 1 CED84001 X.sub.622 M1 69 1411421 C T 3 CED83999 X.sub.623 M1 69 1530586 C T 3 CED84038 X.sub.624 M1 69 1590302 G A 1 CED84059 X.sub.625 M1 69 1617492 A G 2 CED84068 X.sub.626 M1 69 1652288 C T 3 CED84077 X.sub.627 M1 69 1674261 C T 1 CED84084 X.sub.628 M1 69 1678475 C T 2 CED84085 X.sub.629 M1 69 1687394 G A 1 CED84087 X.sub.630 M1 69 1688555 C T 1 CED84088 X.sub.631 M1 69 1701017 G A 2 CED84094 X.sub.632 M1 69 1714728 G A 3 CED84097 X.sub.633 M1 69 1750423 C T 1 CED84111 X.sub.634 M1 69 1788929 G A 2 CED84124 X.sub.635 M1 69 1790823 C T 2 CED84125 X.sub.636 M1 69 1792597 C T 2 CED84126 X.sub.637 M1 69 1799816 C T 8 CED84128 X.sub.638 M1 69 1800584 G A 3 CED84129 X.sub.639 M1 69 1854739 G A 3 CED84145 X.sub.640 M1 69 1855951 C T 3 CED84145 X.sub.641 M1 69 1871563 G A 2 CED84153 X.sub.642 M1 69 1878663 C T 3 CED84154 X.sub.643 M1 69 1924621 C T 3 CED84172 X.sub.644 M1 69 1949938 G A 3 CED84182 X.sub.645 M1 69 1967529 C T 1 CED84189 X.sub.646 M1 69 1968848 A G 3 CED84189 X.sub.647 M1 69 2001469 C T 3 CED84197 X.sub.648 M1 69 2009058 G A 8 CED84201 X.sub.649 M1 69 2031440 G A 2 CED84210 X.sub.650 M1 69 2099452 C G 4 CED84233 X.sub.651 M1 69 2099556 C T 4 CED84233 X.sub.652 M1 69 2099559 A T 4 CED84233 X.sub.653 M1 69 2160207 C T 1 CED84255 X.sub.654 M1 69 2219444 G A 2 CED84271 X.sub.655 M1 69 2226317 C T 2 CED84272 X.sub.656 M1 69 2231926 G A 2 CED84274 X.sub.657 M1 69 2237950 C T 2 CED84276 X.sub.658 M1 69 2263333 G A 2 CED84285 X.sub.659 M1 69 2275703 G A 2 CED84290 X.sub.660 M1 69 2320079 T A 3 CED84303 X.sub.661 M1 69 2402826 C T 2 CED84333 X.sub.662 M1 69 2421550 C T 2 CED84338 X.sub.663 M1 69 2438727 C T 3 CED84343 X.sub.664 M1 69 2483433 G A 3 CED84352 X.sub.665 M1 72 93 T C 6 X.sub.666 M1 72 584 G A 6 X.sub.667 M1 72 856 C T 6 X.sub.668 M1 72 1163 C T 6 X.sub.669 M1 73 928 C T 4 CDZ96628 X.sub.670 M1 77 18912 A G 2 CDZ96635 X.sub.671 M1 77 39842 G A 8 CDZ96646 X.sub.672 M1 77 47151 C T 2 CDZ96648 X.sub.673 M1 77 84022 G A 8 CDZ96659 X.sub.674 M1 77 116691 G A 3 CDZ96671 X.sub.675 M1 78 6333 G A 8 CED84360 X.sub.676 M1 78 15591 C T 3 CED84363 X.sub.677 M1 78 26915 C T 3 CED84366 X.sub.678 M1 78 35200 G A 2 CED84371 X.sub.679 M1 78 100169 G A 2 CED84388 X.sub.680 M1 78 158434 G A 2 CED84406 X.sub.681 M1 78 158534 G A 2 CED84406 X.sub.682 M1 78 191358 G A 3 CED84414 X.sub.683 M1 78 200234 C T 2 CED84420 X.sub.684 M1 78 238854 C T 3 CED84430 X.sub.685 M1 78 262614 A C 2 CED84438 X.sub.686 M1 78 263828 T C 3 CED84438 X.sub.687 M1 78 263896 T C 3 CED84438 X.sub.688 M1 78 281454 C A 3 CED84441 X.sub.689 M1 78 292068 C T 1 CED84442 X.sub.690 M1 78 298141 C G 3 CED84443 X.sub.691 M1 78 299166 G A 3 CED84443 X.sub.692 M1 78 299644 G A 3 CED84443 X.sub.693 M1 78 302700 A G 2 CED84443 X.sub.694 M1 78 311586 C T 2 CED84447 X.sub.695 M1 78 333312 A G 3 CED84452 X.sub.696 M1 78 376706 C T 3 CED84464 X.sub.697 M1 78 386356 C T 2 CED84472 X.sub.698 M1 78 439640 C T 2 CED84487 X.sub.699 M1 78 480244 C T 1 CED84502 X.sub.700 M1 78 487303 C T 3 CED84505 X.sub.701 M1 78 611362 C T 2 CED84546 X.sub.702 M1 78 626958 C A 4 CED84549 X.sub.703 M1 78 666005 C T 3 CED84562 X.sub.704 M1 78 706821 A G 3 CED84578 X.sub.705 M1 78 708376 C T 2 CED84580 X.sub.706 M1 78 710966 G A 2 CED84581 X.sub.707 M1 78 726983 G A 2 CED84587 X.sub.708 M1 78 763771 G A 3 CED84600 X.sub.709 M1 78 774252 G A 2 CED84602 X.sub.710 M1 78 811274 G A 2 CED84614 X.sub.711 M1 78 895505 C T 2 CED84642 X.sub.712 M1 78 918865 C T 1 CED84651 X.sub.713 M1 78 952815 G A 2 CED84662 X.sub.714 M1 78 952860 G A 2 CED84662 X.sub.715 M1 78 976799 C T 3 CED84672 X.sub.716 M1 78 1023381 G A 2 CED84688 X.sub.717 M1 78 1066463 C T 2 CED84704 X.sub.718 M1 78 1095322 C T 2 CED84715 X.sub.719 M1 78 1100041 G A 3 CED84715 X.sub.720 M1 78 1112587 C T 2 CED84722 X.sub.721 M1 78 1115511 G A 1 CED84723 X.sub.722 M1 78 1142438 G A 2 CED84729 X.sub.723 M1 78 1216573 C T 1 CED84752 X.sub.724 M1 78 1266077 G A 2 CED84770 X.sub.725 M1 78 1302286 C T 3 CED84782 X.sub.726 M1 78 1315312 C T 3 CED84786 X.sub.727 M1 78 1317124 G A 3 CED84787 X.sub.728 M1 78 1322274 G A 1 CED84790 X.sub.729 M1 78 1324423 T C 2 CED84791 X.sub.730 M1 78 1344640 C T 3 CED84795 X.sub.731 M1 78 1397982 G A 3 CED84818 X.sub.732 M1 78 1426722 C T 2 CED84829 X.sub.733 M1 78 1495995 C T 1 CED84852 X.sub.734 M1 78 1520586 C T 1 CED84855 X.sub.735 M1 78 1563246 C T 3 CED84865 X.sub.736 M1 78 1568326 C T 2 CED84868 X.sub.737 M1 78 1642170 G A 3 CED84889 X.sub.738 M1 78 1660408 G A 2 CED84897 X.sub.739 M1 78 1730707 C T 3 CED84922 X.sub.740 M1 78 1742796 G A 3 CED84926 X.sub.741 M1 78 1745162 C T 4 CED84927 X.sub.742 M1 79 65 G A 3 CDZ96674 X.sub.743 M1 79 133 A G 3 CDZ96674 X.sub.744 M1 79 3698 C G 4 CDZ96674 X.sub.745 M1 79 20544 A G 2 CDZ96675 X.sub.746 M1 79 57804 G A 2 CDZ96687 X.sub.747 M1 79 64133 C T 3 CDZ96688 X.sub.748 M1 79 64658 C T 3 CDZ96688 X.sub.749 M1 79 65402 C T 3 CDZ96688 X.sub.750 M1 79 132683 C T 2 CDZ96713 X.sub.751 M1 79 171814 C T 3 CDZ96727 X.sub.752 M1 79 307021 C T 3 CDZ96777 X.sub.753 M1 79 346823 G A 2 CDZ96789 X.sub.754 M1 79 378247 C T 2 CDZ96800 X.sub.755 M1 79 409085 C T 8 CDZ96810 X.sub.756 M1 79 412661 G A 2 CDZ96811 X.sub.757 M1 79 492523 C T 3 CDZ96842 X.sub.758 M1 79 508274 C T 8 CDZ96848 X.sub.759 M1 79 575411 C T 3 CDZ96868 X.sub.760 M1 79 579674 G A 1 CDZ96871 X.sub.761 M1 79 617057 C T 2 CDZ96882 X.sub.762 M1 79 679140 C T 2 CDZ96904 X.sub.763 M1 79 696174 G A 4 CDZ96911 X.sub.764 M1 79 710422 G A 2 CDZ96916 X.sub.765 M1 79 735053 T C 2 CDZ96928 X.sub.766 M1 79 749596 G A 4 CDZ96930 X.sub.767 M1 79 759403 C T 3 CDZ96931 X.sub.768 M1 79 759659 G A 2 CDZ96931 X.sub.769 M1 79 760458 G T 1 CDZ96932 X.sub.770 M1 79 760541 A G 2 CDZ96932 X.sub.771 M1 79 760891 A G 2 CDZ96932 X.sub.772 M1 79 760904 T C 2 CDZ96932 X.sub.773 M1 79 761056 T C 3 CDZ96932 X.sub.774 M1 79 768537 A G 4 CDZ96933 X.sub.775 M1 79 776112 A G 4 CDZ96934 X.sub.776 M1 79 786064 A G 3 CDZ96934 X.sub.777 M1 79 798799 C T 1 CDZ96939 X.sub.778 M1 79 914302 C T 3 CDZ96977 X.sub.779 M1 79 940003 C T 2 CDZ96991 X.sub.780 M1 79 962607 G A 3 CDZ96997 X.sub.781 M1 79 1000786 A G 1 CDZ97007 X.sub.782 M1 79 1002991 G A 1 CDZ97008 X.sub.783 M1 79 1044652 G A 1 CDZ97023 X.sub.784 M1 79 1056822 G T 3 CDZ97025 X.sub.785 M1 79 1069426 C T 2 CDZ97032 X.sub.786 M1 79 1075960 G A 8 CDZ97034 X.sub.787 M1 79 1086267 G A 2 CDZ97038 X.sub.788 M1 79 1123288 C T 2 CDZ97049 X.sub.789 M1 79 1140763 G A 3 CDZ97053 X.sub.790 M1 79 1191202 G A 3 CDZ97070 X.sub.791 M1 79 1229129 G A 2 CDZ97086 X.sub.792 M1 79 1231740 C T 2 CDZ97087 X.sub.793 M1 79 1265502 C T 1 CDZ97100 X.sub.794 M1 79 1284476 C T 1 CDZ97106 X.sub.795 M1 79 1318034 C T 1 CDZ97117 X.sub.796 M1 79 1336766 C T 4 CDZ97121 X.sub.797 M1 79 1344403 C T 2 CDZ97124 X.sub.798 M1 79 1367232 C T 5 CDZ97129 X.sub.799 M1 79 1387800 G A 3 CDZ97135 X.sub.800 M1 79 1410287 C T 1 CDZ97145 X.sub.801 M1 79 1410481 G A 1 CDZ97145 X.sub.802 M1 79 1423385 C T 1 CDZ97150 X.sub.803 M1 79 1430954 G A 2 CDZ97152 X.sub.804 M1 79 1471094 C T 3 CDZ97163 X.sub.805 M1 79 1540205 C T 2 CDZ97186 X.sub.806 M1 79 1564902 C T 1 CDZ97195 X.sub.807 M1 79 1624415 G A 1 CDZ97217 X.sub.808 M1 79 1674448 G A 4 CDZ97228 X.sub.809 M1 79 1732022 G A 3 CDZ97245 X.sub.810 M1 79 1797660 C T 3 CDZ97265 X.sub.811 M1 79 1797676 G A 3 CDZ97265 X.sub.812 M1 79 1842448 G A 2 CDZ97282 X.sub.813 M1 79 1854359 G A 3 CDZ97285 X.sub.814 M1 79 1855037 A G 3 CDZ97285 X.sub.815 M1 79 1859220 A G 1 CDZ97291 X.sub.816 M1 79 1883004 A G 1 CDZ97298 X.sub.817 M1 79 1883021 C A 2 CDZ97298 X.sub.818 M1 79 1930688 G A 3 CDZ97315 X.sub.819 M1 79 1934434 G A 3 CDZ97316 X.sub.820 M1 79 1977783 G A 3 CDZ97330 X.sub.821 M1 79 1990424 G A 2 CDZ97334 X.sub.822 M1 79 2013304 G A 2 CDZ97344 X.sub.823 M1 79 2013361 C T 8 CDZ97344 X.sub.824 M1 79 2045917 C T 3 CDZ97355 X.sub.825 M1 79 2052320 C T 2 CDZ97361 X.sub.826 M1 79 2073260 G T 3 CDZ97366 X.sub.827 M1 79 2089423 C T 2 CDZ97372 X.sub.828 M1 79 2113064 G A 3 CDZ97381 X.sub.829 M1 79 2121041 G A 3 CDZ97380 X.sub.830 M1 79 2152573 C T 2 CDZ97392 X.sub.831 M1 79 2169813 C T 3 CDZ97396 X.sub.832 M1 79 2172085 C T 3 CDZ97397 X.sub.833 M1 79 2179936 G A 1 CDZ97402 X.sub.834 M1 79 2187306 C T 3 CDZ97404 X.sub.835 M1 79 2188410 G A 2 CDZ97405 X.sub.836 M1 79 2220254 C T 3 CDZ97414 X.sub.837 M1 79 2268540 C T 1 CDZ97435 X.sub.838 M1 79 2271652 G C 2 CDZ97437 X.sub.839 M1 79 2294761 G A 8 CDZ97444 X.sub.840 M1 79 2320060 G A 2 CDZ97454 X.sub.841 M1 79 2339881 C G 3 CDZ97460 X.sub.842 M1 79 2340326 G A 3 CDZ97462 X.sub.843 M1 85 462 G A 6 X.sub.844 M1 85 463 G G 6 X.sub.845 M1 85 467 A T 6 X.sub.846 M1 85 512 A G 6 X.sub.847 M1 85 516 G A 6 X.sub.848 M1 85 521 C T 6 X.sub.849 M1 85 522 A G 6 X.sub.850 M1 86 230 A G 6 X.sub.851 M1 88 119 C T 3 CDZ97464 X.sub.852 M1 88 196 G A 3 CDZ97464 X.sub.853 M1 88 898 C T 4 CDZ97464 X.sub.854 M1 99 245 G A 6 X.sub.855 M1 105 258 A G 2 CDZ97474 X.sub.856 M1 105 429 C T 4 CDZ97474 X.sub.857 M1 106 278 A G 6 X.sub.858 M1 109 396 T C 6 X.sub.859 M1 115 361 G A 6 X.sub.860 M1 118 396 C T 2 CDZ97478 X.sub.861 M1 118 870 G A 4 CDZ97478 X.sub.862 M1 118 1491 G A 4 CDZ97478 X.sub.863 M1 124 72117 G A 2 CDZ97501 X.sub.864 M1 124 72760 G A 1 CDZ97501 X.sub.865 M1 124 94611 G A 1 CDZ97507 X.sub.866 M1 124 156052 G A 2 CDZ97524 X.sub.867 M1 124 171458 G T 1 CDZ97530 X.sub.868 M1 124 179336 C T 1 CDZ97533 X.sub.869 M1 124 207992 C T 3 CDZ97541 X.sub.870 M1 124 222249 C T 1 CDZ97547 X.sub.871 M1 125 35864 T C 3 CDZ97573 X.sub.872 M1 129 299 G A 3 CDZ97577 X.sub.873 M1 129 433 G A 3 CDZ97577 X.sub.874 M1 129 856 G A 2 CDZ97577 X.sub.875 M1 129 1013 C T 1 CDZ97577 X.sub.876 M1 130 674 C T 4 CDZ97578 X.sub.877 M1 138 123 G T 6 X.sub.878 M1 141 15764 C T 2 CDZ97587 X.sub.879 M1 141 25126 C T 2 CDZ97591 X.sub.880 M1 149 1663 A G 3 CDZ97598 X.sub.881 M1 149 2074 T G 3 CDZ97598 X.sub.882 M1 149 2453 C T 3 CDZ97598 X.sub.883 M1 159 106 A C 6 X.sub.884 M1 162 47699 G A 2 CDZ97619 X.sub.885 M1 162 70405 A G 1 CDZ97625 X.sub.886 M1 162 148101 G A 3 CDZ97648 X.sub.887 M1 162 207179 C T 8 CDZ97668 X.sub.888 M1 162 209584 C T 3 CDZ97670 X.sub.889 M1 162 223407 C T 2 CDZ97674 X.sub.890 M1 162 227242 G A 3 CDZ97674 X.sub.891 M1 162 233092 C T 3 CDZ97676 X.sub.892 M1 162 291566 G A 4 CDZ97695 X.sub.893 M1 162 308369 T C 1 CDZ97702 X.sub.894 M1 162 318857 G A 4 CDZ97703 X.sub.895 M1 162 320785 G C 4 CDZ97703 X.sub.896 M1 162 320786 T G 4 CDZ97703 X.sub.897 M1 162 321460 C G 4 CDZ97703 X.sub.898 M1 162 321463 A C 4 CDZ97703 X.sub.899 M1 162 322591 G A 4 CDZ97703 X.sub.900 M1 162 323448 T G 2 CDZ97703 X.sub.901 M1 162 323451 T G 2 CDZ97703 X.sub.902 M1 162 323480 T C 1 CDZ97703 X.sub.903 M1 162 323735 A G 1 CDZ97703 X.sub.904 M1 162 324114 T C 2 CDZ97703 X.sub.905 M1 162 324139 C T 2 CDZ97703 X.sub.906 M1 162 324568 A G 2 CDZ97703 X.sub.907 M1 162 360320 G A 2 CDZ97714 X.sub.908 M1 162 398165 C T 1 CDZ97730 X.sub.909 M1 162 414579 C T 8 CDZ97737 X.sub.910 M1 162 424391 C T 3 CDZ97740 X.sub.911 M1 162 444123 T C 2 CDZ97748 X.sub.912 M1 162 467207 C T 3 CDZ97755 X.sub.913 M1 162 491906 G A 3 CDZ97764 X.sub.914 M1 162 492101 G A 3 CDZ97764 X.sub.915 M1 162 501886 C T 8 CDZ97769 X.sub.916 M1 162 507949 G A 2 CDZ97771 X.sub.917 M1 162 632311 G A 2 CDZ97814 X.sub.918 M1 162 633321 G A 2 CDZ97814 X.sub.919 M1 162 633633 G A 1 CDZ97814 X.sub.920 M1 162 638083 C T 1 CDZ97814 X.sub.921 M1 162 640005 C T 2 CDZ97815 X.sub.922 M1 162 674192 C T 1 CDZ97824 X.sub.923 M1 162 691535 C T 2 CDZ97828 X.sub.924 M1 162 738675 G A 3 CDZ97842 X.sub.925 M1 162 738686 C T 3 CDZ97842 X.sub.926 M1 162 792386 G A 3 CDZ97863 X.sub.927 M1 162 808830 G A 3 CDZ97869 X.sub.928 M1 162 871911 C T 8 CDZ97890 X.sub.929 M1 185 2337 C T 8 CDZ97958 X.sub.930 M1 189 32 G A 3 CDZ97960 X.sub.931 M1 189 1306 C T 3 CDZ97961 X.sub.932 M1 189 64473 G A 2 CDZ97979 X.sub.933 M1 189 126573 G A 3 CDZ97996 X.sub.934 M1 189 127356 G A 3 CDZ97996 X.sub.935 M1 189 194647 A G 3 CDZ98020 X.sub.936 M1 189 194665 A G 3 CDZ98020 X.sub.937 M1 189 212649 C T 2 CDZ98028 X.sub.938 M1 189 303106 G A 2 CDZ98057 X.sub.939 M1 189 323680 C T 2 CDZ98063 X.sub.940 M1 189 332957 G A 3 CDZ98065 X.sub.941 M1 189 371247 G A 5 CDZ98078 X.sub.942 M1 189 394551 C T 2 CDZ98085 X.sub.943 M1 189 452298 G A 2 CDZ98106 X.sub.944 M1 191 342 A G 3 CDZ98107 X.sub.945 M1 191 347 C T 3 CDZ98107 X.sub.946 M1 191 427 C T 3 CDZ98107 X.sub.947 M1 191 451 C T 3 CDZ98107 X.sub.948 M1 191 487 A G 3 CDZ98107 X.sub.949 M1 197 624 C T 3 CDZ98111 X.sub.950 M1 198 202 C A 6 X.sub.951 M1 198 203 G A 6 X.sub.952 M1 198 238 C T 6 X.sub.953 M1 198 265 C T 6 X.sub.954 M1 199 688 C T 6 X.sub.955 M1 199 911 C T 6 X.sub.956 M1 199 971 C T 6 X.sub.957 M1 199 1218 C T 6 X.sub.958 M1 202 171 C T 6 X.sub.959 M1 205 360 C T 3 CDZ98112 X.sub.960 M1 205 981 C T 4 CDZ98112 X.sub.961 M1 206 406 G A 6 X.sub.962 M1 208 117 G A 6 X.sub.963 M1 208 476 G A 6 X.sub.964 M1 208 616 G A 6 X.sub.965 M1 208 935 G A 6 X.sub.966 M1 209 312 C T 8 CDZ98113 X.sub.967 M1 220 116 C G 6 X.sub.968 M1 223 93 G A 4 CDZ98118 X.sub.969 M1 223 102 A G 4 CDZ98118 X.sub.970 M1 223 133 A G 4 CDZ98118 X.sub.971 M1 223 150 T C 4 CDZ98118 X.sub.972 M1 223 155 A C 4 CDZ98118 X.sub.973 M1 223 158 T C 4 CDZ98118 X.sub.974 M1 223 160 C T 4 CDZ98118 X.sub.975 M1 223 175 G A 4 CDZ98118 X.sub.976 M1 223 177 A G 4 CDZ98118 X.sub.977 M1 224 27 T A 6 X.sub.978 M1 225 317 C T 6 X.sub.979 M1 227 202 G A 6 X.sub.980 M1 232 340 G A 3 CDZ98119 X.sub.981 M1 232 1379 C T 1 CDZ98119 X.sub.982 M1 232 1521 C T 2 CDZ98119 X.sub.983 M1 232 1662 G A 2 CDZ98119 X.sub.984 M1 232 1761 C T 2 CDZ98119 X.sub.985 M1 232 2027 C T 4 CDZ98119 X.sub.986 M1 232 3060 C T 2 CDZ98120 X.sub.987 M1 232 3284 C T 4 CDZ98119 X.sub.988 M1 232 4437 G A 2 CDZ98121 X.sub.989 M1 232 4561 C T 3 CDZ98120 X.sub.990 M1 242 7334 C T 2 CDZ98125 X.sub.991 M1 242 41710 G A 3 CDZ98131 X.sub.992 M1 242 50262 G A 8 CDZ98135 X.sub.993 M1 242 88037 G A 2 CDZ98147 X.sub.994 M1 242 106805 G A 3 CDZ98152 X.sub.995 M1 242 107587 G A 4 CDZ98153 X.sub.996 M1 242 119446 T C 1 CDZ98156 X.sub.997 M1 242 149113 C T 2 CDZ98165 X.sub.998 M1 242 150461 C T 3 CDZ98164 X.sub.999 M1 242 168689 G A 1 CDZ98172 X.sub.1000 M1 242 213986 G A 8 CDZ98185 X.sub.1001 M1 242 227271 C T 3 CDZ98191 X.sub.1002 M1 242 233088 G A 2 CDZ98193 X.sub.1003 M1 242 254710 A G 9 CDZ98200 X.sub.1004 M1 242 309675 G A 2 CDZ98216 X.sub.1005 M1 242 310353 G A 2 CDZ98216 X.sub.1006 M1 242 357209 G A 1 CDZ98233 X.sub.1007 M1 242 404132 G A 3 CDZ98248 X.sub.1008 M1 242 405825 G A 3 CDZ98250 X.sub.1009 M1 242 412676 G A 3 CDZ98249 X.sub.1010 M1 242 439891 T A 2 CDZ98259 X.sub.1011 M1 242 472562 C T 3 CDZ98266 X.sub.1012 M1 242 485936 G A 4 CDZ98270 X.sub.1013 M1 242 492389 G A 2 CDZ98274 X.sub.1014 M1 242 514780 C T 2 CDZ98282 X.sub.1015 M1 242 542663 G A 3 CDZ98290 X.sub.1016 M1 242 545031 G A 3 CDZ98293 X.sub.1017 M1 242 559999 G A 2 CDZ98297 X.sub.1018 M1 242 577367 G A 3 CDZ98302 X.sub.1019 M1 242 602456 G A 2 CDZ98308 X.sub.1020 M1 242 602531 G A 2 CDZ98308 X.sub.1021 M1 242 604704 C T 2 CDZ98309 X.sub.1022 M1 249 206 G A 4 CED84929 X.sub.1023 M1 249 7968 A T 3 CED84930 X.sub.1024 M1 249 42295 C T 2 CED84942 X.sub.1025 M1 249 72016 C T 3 CED84950 X.sub.1026 M1 249 142920 G A 1 CED84978 X.sub.1027 M1 249 157550 C T 8 CED84983 X.sub.1028 M1 249 159819 C T 1 CED84984 X.sub.1029 M1 249 191304 C T 2 CED84988 X.sub.1030 M1 249 269707 G A 2 CED85013 X.sub.1031 M1 249 272075 C T 8 CED85013 X.sub.1032 M1 249 289154 C T 2 CED85018 X.sub.1033 M1 249 305975 G A 2 CED85023 X.sub.1034 M1 249 342990 G A 2 CED85036 X.sub.1035 M1 249 371535 G A 2 CED85048 X.sub.1036 M1 249 377814 G A 3 CED85051 X.sub.1037 M1 249 485782 C T 3 CED85089 X.sub.1038 M1 249 487588 G A 2 CED85090 X.sub.1039 M1 249 500195 C T 8 CED85093 X.sub.1040 M1 249 501310 C T 3 CED85093 X.sub.1041 M1 249 501510 T C 3 CED85093 X.sub.1042 M1 249 509901 C T 1 CED85096 X.sub.1043 M1 249 532943 A G 3 CED85099 X.sub.1044 M1 249 565916 C T 4 CED85113 X.sub.1045 M1 249 568518 C T 2 CED85115 X.sub.1046 M1 249 574798 C T 1 CED85117 X.sub.1047 M1 249 598579 C T 2 CED85125 X.sub.1048 M1 249 637944 G A 1 CED85135 X.sub.1049 M1 249 654772 C T 4 CED85141 X.sub.1050 M1 249 660408 G A 2 CED85144 X.sub.1051 M1 249 715551 G A 3 CED85163 X.sub.1052 M1 249 772481 G A 3 CED85180 X.sub.1053 M1 249 854220 G A 2 CED85201 X.sub.1054 M1 249 871689 G A 5 CED85204 X.sub.1055 M1 249 889853 G A 1 CED85211 X.sub.1056 M1 249 911274 C T 2 CED85218 X.sub.1057 M1 249 927876 C T 4 CED85222 X.sub.1058 M1 249 932606 C T 3 CED85223 X.sub.1059 M1 249 945434 C T 3 CED85227 X.sub.1060 M1 249 945727 C T 3 CED85227 X.sub.1061 M1 249 969333 G T 3 CED85238 X.sub.1062 M1 249 977170 C T 2 CED85242 X.sub.1063 M1 249 989520 C T 3 CED85243 X.sub.1064 M1 249 1014098 C T 2 CED85252 X.sub.1065 M1 249 1014926 C T 2 CED85252 X.sub.1066 M1 249 1021827 C T 2 CED85254 X.sub.1067 M1 249 1050123 C T 2 CED85262 X.sub.1068 M1 249 1076166 C T 1 CED85270 X.sub.1069 M1 249 1114790 G A 1 CED85283 X.sub.1070 M1 249 1127638 C T 2 CED85286 X.sub.1071 M1 249 1144309 G A 3 CED85291 X.sub.1072 M1 249 1155955 C T 3 CED85297 X.sub.1073 M1 249 1176977 G A 1 CED85303 X.sub.1074 M1 249 1195367 G A 3 CED85307 X.sub.1075 M1 249 1213338 C T 3 CED85314 X.sub.1076 M1 249 1230068 C T 2 CED85319 X.sub.1077 M1 249 1286733 G A 3 CED85336 X.sub.1078 M1 249 1299472 C T 1 CED85343 X.sub.1079 M1 249 1331428 G A 3 CED85352 X.sub.1080 M1 249 1350079 G A 2 CED85357 X.sub.1081 M1 249 1359399 G A 1 CED85360 X.sub.1082 M1 249 1391183 C T 2 CED85372 X.sub.1083 M1 249 1452855 C T 2 CED85396 X.sub.1084 M1 249 1452994 C T 3 CED85394 X.sub.1085 M1 249 1471661 C T 1 CED85402 X.sub.1086 M1 249 1486828 G A 1 CED85411 X.sub.1087 M1 249 1486831 T C 1 CED85411 X.sub.1088 M1 249 1498029 T C 3 CED85415 X.sub.1089 M1 249 1498823 T C 2 CED85414 X.sub.1090 M1 249 1498829 C T 2 CED85414 X.sub.1091 M1 249 1499741 G A 2 CED85415 X.sub.1092 M1 249 1502631 G T 2 CED85416 X.sub.1093 M1 249 1502641 T A 2 CED85416 X.sub.1094 M1 249 1502819 T G 1 CED85416 X.sub.1095 M1 249 1505138 G A 3 CED85416 X.sub.1096 M1 249 1518591 T A 3 CED85419 X.sub.1097 M1 249 1519431 A G 3 CED85419 X.sub.1098 M1 249 1520169 C T 1 CED85420 X.sub.1099 M1 249 1567124 G A 3 CED85432 X.sub.1100 M1 249 1599907 C T 3 CED85444 X.sub.1101 M1 249 1619036 G A 2 CED85450 X.sub.1102 M1 249 1653615 T G 2 CED85457 X.sub.1103 M1 249 1653962 C T 4 CED85458 X.sub.1104 M1 249 1666185 C T 3 CED85460 X.sub.1105 M1 249 1726421 G A 2 CED85476 X.sub.1106 M1 249 1726777 C T 3 CED85474 X.sub.1107 M1 249 1729264 C T 1 CED85476 X.sub.1108 M1 249 1741408 C T 1 CED85480 X.sub.1109 M1 249 1760715 C T 3 CED85489 X.sub.1110 M1 249 1780551 A G 3 CED85493 X.sub.1111 M1 249 1780569 A G 3 CED85493 X.sub.1112 M1 249 1786050 C T 3 CED85496 X.sub.1113 M1 249 1801965 G A 3 CED85501 X.sub.1114 M1 249 1803575 C T 2 CED85502 X.sub.1115 M1 249 1804835 G A 2 CED85502 X.sub.1116 M1 249 1834426 G A 2 CED85511 X.sub.1117 M1 249 1862072 C T 1 CED85520 X.sub.1118 M1 249 1880762 G A 1 CED85525 X.sub.1119 M1 249 1944026 G A 1 CED85545 X.sub.1120 M1 249 1963639 G T 2 CED85550 X.sub.1121 M1 249 1981230 G A 3 CED85557 X.sub.1122 M1 249 1988505 C T 3 CED85560 X.sub.1123 M1 249 2010712 G A 3 CED85564 X.sub.1124 M1 249 2015272 G A 2 CED85567 X.sub.1125 M1 249 2027477 G A 1 CED85573 X.sub.1126 M1 249 2032298 C T 2 CED85575 X.sub.1127 M1 249 2063221 G A 2 CED85586 X.sub.1128 M1 249 2080239 G A 3 CED85590 X.sub.1129 M1 249 2110956 C T 1 CED85603 X.sub.1130 M1 249 2124517 C T 2 CED85607 X.sub.1131 M1 249 2183695 G A 2 CED85623 X.sub.1132 M1 249 2198205 G A 8 CED85628 X.sub.1133 M1 249 2223626 G A 1 CED85633 X.sub.1134 M1 249 2255547 G C 3 CED85640 X.sub.1135 M1 251 874 G A 6 X.sub.1136 M1 252 512 C T 6 X.sub.1137 M1 252 524 C T 6 X.sub.1138 M1 258 267 G A 6 X.sub.1139 M1 258 1139 A T 6 X.sub.1140 M1 259 91 G C 6 X.sub.1141 M1 260 156 G A 6 X.sub.1142 M1 262 4049 G A 1 CDZ98330 X.sub.1143 M1 262 20959 G A 1 CDZ98336 X.sub.1144 M1 262 30347 G A 2 CDZ98338 X.sub.1145 M1 262 30359 G A 2 CDZ98338 X.sub.1146 M1 262 63941 G A 3 CDZ98349 X.sub.1147 M1 262 81226 G A 2 CDZ98358 X.sub.1148 M1 262 96076 C T 8 CDZ98364 X.sub.1149 M1 262 130174 C T 3 CDZ98372 X.sub.1150 M1 262 148151 C T 3 CDZ98375 X.sub.1151 M1 262 148199 G A 2 CDZ98376 X.sub.1152 M1 262 164438 G A 2 CDZ98383 X.sub.1153 M1 262 191816 C T 2 CDZ98393 X.sub.1154 M1 262 201531 G A 8 CDZ98396 X.sub.1155 M1 262 221937 C T 3 CDZ98403 X.sub.1156 M1 262 225924 G A 3 CDZ98404 X.sub.1157 M1 262 242371 C T 3 CDZ98411 X.sub.1158 M1 262 250756 A G 3 CDZ98412 X.sub.1159 M1 262 319302 G A 1 CDZ98436 X.sub.1160 M1 262 350852 C T 8 CDZ98449 X.sub.1161 M1 262 359947 A G 1 CDZ98451 X.sub.1162 M1 262 366171 G A 3 CDZ98452 X.sub.1163 M1 262 380519 C T 4 CDZ98457 X.sub.1164 M1 262 383215 C T 8 CDZ98459 X.sub.1165 M1 262 390030 C T 2 CDZ98460 X.sub.1166 M1 262 397539 G A 3 CDZ98463 X.sub.1167 M1 262 420102 G A 2 CDZ98468 X.sub.1168 M1 262 444331 G A 2 CDZ98477 X.sub.1169 M1 262 446956 C T 2 CDZ98477 X.sub.1170 M1 262 451669 C T 3 CDZ98478 X.sub.1171 M1 262 498239 C T 8 CDZ98496 X.sub.1172 M1 262 503840 G A 2 CDZ98499 X.sub.1173 M1 262 525946 C T 2 CDZ98509 X.sub.1174 M1 262 539452 A G 3 CDZ98514 X.sub.1175 M1 262 539470 A G 3 CDZ98514 X.sub.1176 M1 262 552414 C T 1 CDZ98518 X.sub.1177 M1 262 557280 G A 2 CDZ98518 X.sub.1178 M1 262 560713 G A 8 CDZ98519 X.sub.1179 M1 262 562795 C T 2 CDZ98521 X.sub.1180 M1 262 567591 G A 2 CDZ98524 X.sub.1181 M1 262 567801 G A 2 CDZ98524 X.sub.1182 M1 262 573667 C T 2 CDZ98526 X.sub.1183 M1 262 618198 G A 3 CDZ98538 X.sub.1184 M1 262 627705 C T 3 CDZ98542 X.sub.1185 M1 262 638804 G C 3 CDZ98544 X.sub.1186 M1 262 639962 A G 4 CDZ98544 X.sub.1187 M1 262 640066 A G 4 CDZ98544 X.sub.1188 M1 262 653920 A G 4 CDZ98545 X.sub.1189 M1 262 656031 C A 4 CDZ98545 X.sub.1190 M1 262 668764 C T 3 CDZ98545 X.sub.1191 M1 262 670988 C T 2 CDZ98547 X.sub.1192 M1 262 691577 C T 2 CDZ98551 X.sub.1193 M1 262 707203 C T 2 CDZ98556 X.sub.1194 M1 262 751209 C T 2 CDZ98572 X.sub.1195 M1 262 771330 G A 2 CDZ98578 X.sub.1196 M1 262 822734 G A 2 CDZ98597 X.sub.1197 M1 262 831789 C T 1 CDZ98601 X.sub.1198 M1 262 835874 C T 3 CDZ98601 X.sub.1199 M1 262 856616 G A 8 CDZ98612 X.sub.1200 M1 262 865999 G A 3 CDZ98613 X.sub.1201 M1 262 971713 G A 3 CDZ98649 X.sub.1202 M1 262 1076581 G A 3 CDZ98679 X.sub.1203 M1 262 1140198 C T 2 CDZ98701 X.sub.1204 M1 262 1209662 G A 2 CDZ98723 X.sub.1205 M1 262 1225705 C T 2 CDZ98730 X.sub.1206 M1 262 1226072 C T 2 CDZ98730 X.sub.1207 M1 262 1229407 G A 3 CDZ98732 X.sub.1208 M1 262 1233054 G A 1 CDZ98733 X.sub.1209 M1 262 1262331 C T 3 CDZ98740 X.sub.1210 M1 262 1277604 G A 1 CDZ98747 X.sub.1211 M1 262 1284428 G A 1 CDZ98748 X.sub.1212 M1 262 1305361 G A 3 CDZ98753 X.sub.1213 M1 262 1329643 C T 3 CDZ98760 X.sub.1214 M1 262 1332176 C T 2 CDZ98761 X.sub.1215 M1 262 1349561 G A 2 CDZ98766 X.sub.1216 M1 262 1351116 A G 1 CDZ98766 X.sub.1217 M1 262 1367361 C T 2 CDZ98772 X.sub.1218 M1 262 1408928 G A 3 CDZ98786 X.sub.1219 M1 262 1424293 G A 2 CDZ98791 X.sub.1220 M1 26 1455677 G A 5 CDZ98804 X.sub.1221 M1 262 1546246 C T 3 CDZ98833 X.sub.1222 M1 262 1549845 C T 2 CDZ98837 X.sub.1223 M1 262 1550311 C T 3 CDZ98836 X.sub.1224 M1 262 1550456 C T 1 CDZ98837 X.sub.1225 M1 262 1615052 G T 2 CDZ98855 X.sub.1226 M1 262 1615762 G A 2 CDZ98855 X.sub.1227 M1 262 1684375 G A 2 CDZ98876 X.sub.1228 M1 262 1692423 T C 3 CDZ98877 X.sub.1229 M1 262 1694625 C T 3 CDZ98878 X.sub.1230 M1 262 1695377 C T 3 CDZ98878 X.sub.1231 M1 262 1709112 G A 3 CDZ98884 X.sub.1232 M1 262 1711527 G A 1 CDZ98886 X.sub.1233 M1 262 1712334 G A 2 CDZ98886 X.sub.1234 M1 262 1713238 G A 4 CDZ98885 X.sub.1235 M1 262 1716385 G A 3 CDZ98887 X.sub.1236 M1 266 85 C T 6 X.sub.1237 M1 266 252 C T 6 X.sub.1238 M2 22 1643 C T 2 CED80056 X.sub.1239 M2 22 2524 G A 4 CED80056 X.sub.1240 M2 28 236 G A 3 CDZ96150 X.sub.1241 M2 28 377 G A 3 CDZ96150 X.sub.1242 M2 28 1506 C T 2 CDZ96150 X.sub.1243 M2 28 1677 C T 4 CDZ96150 X.sub.1244 M2 43 464 G A 2 CDZ96151 X.sub.1245 M2 43 753 C T 2 CDZ96151 X.sub.1246 M2 43 757 G A 1 CDZ96151 X.sub.1247 M2 43 1527 C T 3 CDZ96151 X.sub.1248 M2 43 1748 G A 3 CDZ96151 X.sub.1249 M2 43 1928 C T 3 CDZ96151 X.sub.1250 M2 62 26 T A 4 CDZ96152 X.sub.1251 M2 62 27 T C 4 CDZ96152 X.sub.1252 M2 62 55 T A 4 CDZ96152 X.sub.1253 M2 62 403 C T 1 CDZ96152 X.sub.1254 M2 62 875 G A 2 CDZ96152 X.sub.1255 M2 102 339 C T 4 CDZ96153 X.sub.1256 M2 102 951 G A 4 CDZ96153 X.sub.1257 M2 102 1042 G A 4 CDZ96153 X.sub.1258 M2 102 2334 G A 2 CDZ96153 X.sub.1259 M2 102 2590 C T 2 CDZ96153 X.sub.1260 M2 102 3427 C T 3 CDZ96153 X.sub.1261 M2 176 358 G A 3 CED80058 X.sub.1262 M2 176 1872 G A 4 CED80058 X.sub.1263 M2 176 1980 G A 4 CED80058 X.sub.1264 M2 176 2335 A G 4 CED80058 X.sub.1265 M2 176 2349 G A 4 CED80058 X.sub.1266 M2 179 1525 G A 7 CDZ96154 X.sub.1267 M2 179 1780 C T 7 CDZ96154 X.sub.1268 M2 188 815 C T 2 CED80060 X.sub.1269 M2 188 1174 C T 4 CED80060 X.sub.1270 M2 188 2163 G A 4 CED80060 X.sub.1271 M2 188 2170 G A 4 CED80060 X.sub.1272 M2 247 102 G A 4 CED80061 X.sub.1273 M2 247 989 C T 2 CED80061 X.sub.1274 M2 247 1053 G A 2 CED80061 X.sub.1275 M2 3 142 C T 6 X.sub.1276 M2 7 160 T C 6 X.sub.1277 M2 8 1110 C T 6 X.sub.1278 M2 11 154 A C 6 X.sub.1279 M2 11 158 C T 6 X.sub.1280 M2 15 28 C G 6 X.sub.1281 M2 24 513 T C 3 CDZ96160 X.sub.1282 M2 24 520 C G 3 CDZ96160 X.sub.1283 M2 24 5850 C T 2 CDZ96160 X.sub.1284 M2 24 85162 G A 2 CDZ96190 X.sub.1285 M2 24 169574 C T 3 CDZ96213 X.sub.1286 M2 24 180340 G A 3 CDZ96216 X.sub.1287 M2 24 197593 C T 2 CDZ96224 X.sub.1288 M2 24 236940 G A 3 CDZ96232 X.sub.1289 M2 24 266697 G A 1 CDZ96242 X.sub.1290 M2 24 278319 G A 3 CDZ96245 X.sub.1291 M2 24 307114 G A 2 CDZ96255 X.sub.1292 M2 24 340663 T C 3 CDZ96265 X.sub.1293 M2 24 363770 C T 2 CDZ96275 X.sub.1294 M2 24 420108 G A 3 CDZ96291 X.sub.1295 M2 24 470687 G A 3 CDZ96308 X.sub.1296 M2 24 473232 A G 2 CDZ96308 X.sub.1297 M2 24 491396 C T 3 CDZ96313 X.sub.1298 M2 27 445 C T 6 X.sub.1299 M2 27 1012 A C 6 X.sub.1300 M2 27 1013 T A 6 X.sub.1301 M2 32 158 C T 3 CDZ96332 X.sub.1302 M2 32 215 C T 3 CDZ96332 X.sub.1303 M2 32 2438 C T 3 CDZ96332 X.sub.1304 M2 32 2734 C T 1 CDZ96332 X.sub.1305 M2 32 2821 C T 7 CDZ96332 X.sub.1306 M2 32 3067 C T 2 CDZ96332 X.sub.1307 M2 32 3506 C T 4 CDZ96332 X.sub.1308 M2 32 3562 G A 4 CDZ96332 X.sub.1309 M2 33 399 T A 4 CED82002 X.sub.1310 M2 33 24784 C T 2 CED82008 X.sub.1311 M2 33 45488 C T 3 CED82012 X.sub.1312 M2 33 79913 G A 1 CED82024 X.sub.1313 M2 33 109397 G A 2 CED82038 X.sub.1314 M2 33 109494 G A 2 CED82038 X.sub.1315 M2 33 182417 G A 3 CED82062 X.sub.1316 M2 33 192563 C T 2 CED82066 X.sub.1317 M2 33 257786 C T 1 CED82084 X.sub.1318 M2 33 260027 G A 3 CED82084 X.sub.1319 M2 33 274627 G A 8 CED82091 X.sub.1320 M2 33 283808 C T 2 CED82093 X.sub.1321 M2 33 311532 G A 3 CED82101 X.sub.1322 M2 33 318242 G A 3 CED82105 X.sub.1323 M2 33 325745 C T 2 CED82108 X.sub.1324 M2 33 327840 C T 1 CED82108 X.sub.1325 M2 33 341890 G A 2 CED82113 X.sub.1326 M2 33 374131 A G 6 CED82121- CED82122 X.sub.1327 M2 33 374134 A G 6 CED82121- CED82122 X.sub.1328 M2 33 374137 A T 6 CED82121- CED82122 X.sub.1329 M2 33 374141 C T 6 CED82121- CED82122 X.sub.1330 M2 33 374150 A C 6 CED82121- CED82122 X.sub.1331 M2 33 375339 A G 6 CED82121- CED82122 X.sub.1332 M2 33 375366 T C 6 CED82121- CED82122 X.sub.1333 M2 33 382804 G A 3 CED82122 X.sub.1334 M2 33 385139 G C 2 CED82122 X.sub.1335 M2 33 385319 A C 2 CED82122 X.sub.1336 M2 33 386225 G A 3 CED82124 X.sub.1337 M2 33 397625 C T 3 CED82125 X.sub.1338 M2 33 448815 G A 2 CED82144 X.sub.1339 M2 33 453975 C T 2 CED82147 X.sub.1340 M2 33 455451 C T 3 CED82146 X.sub.1341 M2 33 509127 C T 3 CED82166 X.sub.1342 M2 33 543070 C T 3 CED82179 X.sub.1343 M2 33 606302 G T 5 CED82200 X.sub.1344 M2 33 643436 G A 3 CED82208 X.sub.1345 M2 33 652012 G A 2 CED82212 X.sub.1346 M2 33 690180 C T 1 CED82224 X.sub.1347 M2 33 693516 C T 2 CED82225 X.sub.1348 M2 33 699423 C T 1 CED82227 X.sub.1349 M2 33 774105 G A 2 CED82248 X.sub.1350 M2 33 790955 C T 3 CED82253 X.sub.1351 M2 33 812031 G T 2 CED82262 X.sub.1352 M2 33 816048 C T 3 CED82262 X.sub.1353 M2 33 822243 C T 2 CED82267 X.sub.1354 M2 33 850373 G A 1 CED82278 X.sub.1355 M2 33 929585 T C 1 CED82297 X.sub.1356 M2 33 936350 T A 3 CED82300 X.sub.1357 M2 33 936356 G A 3 CED82300 X.sub.1358 M2 33 936571 A G 3 CED82300 X.sub.1359 M2 33 936600 G A 3 CED82300 X.sub.1360 M2 33 982324 C T 4 CED82312 X.sub.1361 M2 33 983105 G A 3 CED82315 X.sub.1362 M2 33 995886 G A 1 CED82318 X.sub.1363 M2 33 1049699 G A 3 CED82334 X.sub.1364 M2 33 1061503 C A 2 CED82340 X.sub.1365 M2 33 1086609 G A 1 CED82349 X.sub.1366 M2 33 1087773 G A 2 CED82349 X.sub.1367 M2 33 1087834 G A 3 CED82350 X.sub.1368 M2 33 1122362 C T 2 CED82358 X.sub.1369 M2 33 1126814 G A 2 CED82358 X.sub.1370 M2 33 1137501 G A 2 CED82362 X.sub.1371 M2 33 1138444 C T 3 CED82363 X.sub.1372 M2 33 1151553 C T 2 CED82367 X.sub.1373 M2 33 1165914 G A 2 CED82372 X.sub.1374 M2 33 1191727 C T 2 CED82379 X.sub.1375 M2 33 1277762 G A 1 CED82402 X.sub.1376 M2 33 1311181 G A 3 CED82413 X.sub.1377 M2 33 1318841 C T 3 CED82414 X.sub.1378 M2 33 1324395 G A 3 CED82417 X.sub.1379 M2 33 1333932 G A 3 CED82421 X.sub.1380 M2 33 1339376 C T 2 CED82424 X.sub.1381 M2 33 1399499 C T 3 CED82444 X.sub.1382 M2 33 1399524 C T 3 CED82444 X.sub.1383 M2 33 1468155 G A 2 CED82464 X.sub.1384 M2 33 1480984 G A 3 CED82466 X.sub.1385 M2 33 1499347 G A 3 CED82472 X.sub.1386 M2 33 1502644 G A 2 CED82474 X.sub.1387 M2 33 1515369 G A 3 CED82478 X.sub.1388 M2 33 1544767 A C 6 CED82485- CED82486 X.sub.1389 M2 33 1544951 C G 6 CED82485- CED82486 X.sub.1390 M2 33 1572498 C T 8 CED82491 X.sub.1391 M2 33 1587443 C T 3 CED82497 X.sub.1392 M2 33 1596242 C T 3 CED82498 X.sub.1393 M2 33 1638726 G A 3 CED82513 X.sub.1394 M2 33 1642659 G A 2 CED82515 X.sub.1395 M2 33 1666039 G A 3 CED82521 X.sub.1396 M2 33 1698181 G A 3 CED82531 X.sub.1397 M2 33 1700000 G A 2 CED82534 X.sub.1398 M2 33 1714108 G A 1 CED82537 X.sub.1399 M2 33 1714997 G A 2 CED82538 X.sub.1400 M2 33 1838447 G A 4 CED82575 X.sub.1401 M2 33 1848935 C T 1 CED82579 X.sub.1402 M2 33 1860278 G A 3 CED82582 X.sub.1403 M2 33 1861675 C T 2 CED82583 X.sub.1404 M2 33 1887401 C T 1 CED82591 X.sub.1405 M2 33 1938614 G A 2 CED82612 X.sub.1406 M2 33 1959142 G A 8 CED82619 X.sub.1407 M2 33 2010230 C T 2 CED82636 X.sub.1408 M2 33 2013946 C A 2 CED82637 X.sub.1409 M2 33 2014235 C T 2 CED82637 X.sub.1410 M2 33 2033881 C T 1 CED82645 X.sub.1411 M2 33 2054662 G A 1 CED82654 X.sub.1412 M2 36 320 G A 6 X.sub.1413 M2 36 1056 G A 6 X.sub.1414 M2 36 1295 C T 6 X.sub.1415 M2 36 1461 A T 6 X.sub.1416 M2 42 804 C T 4 CDZ96333 X.sub.1417 M2 42 1559 G A 4 CDZ96333 X.sub.1418 M2 48 563 C T 6 X.sub.1419 M2 48 565 T C 6 X.sub.1420 M2 48 576 G A 6 X.sub.1421 M2 48 580 T A 6 K.sub.1422 M2 48 720 A G 6 X.sub.1423 M2 50 145 G A 6 X.sub.1424 M2 52 3042 A G 3 CED82664 X.sub.1425 M2 52 63859 C T 2 CED82686 X.sub.1426 M2 52 144382 C T 3 CED82709 X.sub.1427 M2 52 151974 C T 2 CED82712 X.sub.1428 M2 52 164586 C T 2 CED82716 X.sub.1429 M2 52 183986 C T 8 CED82722 X.sub.1430 M2 52 203253 A G 3 CED82730 X.sub.1431 M2 52 207354 C T 8 CED82730 X.sub.1432 M2 52 214949 C G 3 CED82731 X.sub.1433 M2 52 223289 A G 6 CED82732- CED82733 X.sub.1434 M2 52 241012 A G 3 CED82734 X.sub.1435 M2 52 268499 G A 4 CED82740 X.sub.1436 M2 52 284733 G A 1 CED82747 X.sub.1437 M2 52 316848 C T 2 CED82758 X.sub.1438 M2 52 344346 G A 3 CED82767 X.sub.1439 M2 52 358601 G A 3 CED82772 X.sub.1440 M2 52 360279 C T 3 CED82772 X.sub.1441 M2 52 390095 G A 3 CED82784 X.sub.1442 M2 52 395374 G A 2 CED82786 X.sub.1443 M2 52 398723 C T 3 CED82786 X.sub.1444 M2 52 398728 C T 3 CED82786 X.sub.1445 M2 52 516267 C T 3 CED82823 X.sub.1446 M2 52 552099 G A 2 CED82837 X.sub.1447 M2 52 552173 G A 1 CED82837 X.sub.1448 M2 52 571124 G A 2 CED82845 X.sub.1449 M2 52 629532 A T 3 CED82860 X.sub.1450 M2 52 679670 G A 3 CED82877 X.sub.1451 M2 52 700204 G A 8 CED82888 X.sub.1452 M2 52 725138 C T 5 CED82899 X.sub.1453 M2 52 746548 G A 1 CED82907 X.sub.1454 M2 52 749772 G A 1 CED82908 X.sub.1455 M2 52 758326 C T 2 CED82912 X.sub.1456 M2 52 817452 T A 2 CED82928 X.sub.1457 M2 52 818592 A G 3 CED82929 X.sub.1458 M2 52 837237 C T 2 CED82934 X.sub.1459 M2 52 840755 C T 1 CED82935 X.sub.1460 M2 52 849671 G A 1 CED82940 X.sub.1461 M2 52 861376 C T 8 CED82946 X.sub.1462 M2 52 868578 C T 2 CED82948 X.sub.1463 M2 52 870083 G A 2 CED82949 X.sub.1464 M2 52 890412 C T 3 CED82956 X.sub.1465 M2 52 928854 C T 2 CED82971 X.sub.1466 M2 52 938650 G A 3 CED82973 X.sub.1467 M2 52 967316 A T 2 CED82984 X.sub.1468 M2 52 967701 T A 3 CED82983 X.sub.1469 M2 52 1003899 G A 2 CED83001 X.sub.1470 M2 52 1029498 G A 1 CED83007 X.sub.1471 M2 52 1043011 C T 1 CED83012 X.sub.1472 M2 52 1067895 C T 1 CED83020 X.sub.1473 M2 52 1093730 C T 3 CED83025 X.sub.1474 M2 52 1151398 G A 3 CED83046 X.sub.1475 M2 52 1158103 C T 3 CED83051 X.sub.1476 M2 52 1219894 C T 3 CED83071 X.sub.1477 M2 52 1290031 C T 3 CED83096 X.sub.1478 M2 52 1292343 G A 1 CED83098 X.sub.1479 M2 52 1336560 G A 2 CED83113 X.sub.1480 M2 52 1363357 G A 3 CED83122 X.sub.1481 M2 52 1363405 C T 1 CED83123 X.sub.1482 M2 52 1365822 C T 1 CED83124 X.sub.1483 M2 52 1372536 G T 2 CED83125 X.sub.1484 M2 52 1379155 G A 2 CED83128 X.sub.1485 M2 52 1381652 C T 1 CED83129 X.sub.1486 M2 52 1392238 C T 3 CED83130 X.sub.1487 M2 52 1399439 G A 2 CED83134 X.sub.1488 M2 52 1465985 G A 3 CED83159 X.sub.1489 M2 52 1509004 G A 2 CED83177 X.sub.1490 M2 52 1526796 G A 2 CED83181 X.sub.1491 M2 52 1562633 C T 2 CED83195 X.sub.1492 M2 52 1583655 C T 2 CED83206 X.sub.1493 M2 52 1688685 C T 2 CED83243 X.sub.1494 M2 52 1708900 A G 3 CED83249 X.sub.1495 M2 52 1708985 C T 8 CED83248 X.sub.1496 M2 52 1715136 C T 8 CED83250 X.sub.1497 M2 52 1716210 C T 3 CED83250 X.sub.1498 M2 52 1760440 G A 2 CED83266 X.sub.1499 M2 52 1793370 G A 3 CED83275 X.sub.1500 M2 52 1796780 G A 3 CED83279 X.sub.1501 M2 52 1807309 G A 3 CED83283 X.sub.1502 M2 52 1809897 G A 3 CED83285 X.sub.1503 M2 52 1826635 G A 1 CED83289 X.sub.1504 M2 52 1833707 C A 3 CED83292 X.sub.1505 M2 52 1871310 C T 2 CED83304 X.sub.1506 M2 52 1874150 G T 3 CED83305 X.sub.1507 M2 52 1888989 C T 2 CED83312 X.sub.1508 M2 52 1893352 G A 2 CED83313 X.sub.1509 M2 52 1915927 G A 3 CED83315 X.sub.1510 M2 52 1956479 C T 3 CED83330 X.sub.1511 M2 52 1963875 G A 3 CED83335 X.sub.1512 M2 52 1968215 A G 1 CED83335 X.sub.1513 M2 52 1987096 G A 4 CED83341 X.sub.1514 M2 52 2029893 G A 3 CED83351 X.sub.1515 M2 52 2041781 C T 8 CED83355 X.sub.1516 M2 52 2050245 G A 3 CED83359 X.sub.1517 M2 52 2081390 G A 1 CED83367 X.sub.1518 M2 52 2120665 C T 4 CED83376 X.sub.1519 M2 52 2136885 A G 1 CED83382 X.sub.1520 M2 52 2162878 G A 2 CED83392 X.sub.1521 M2 52 2207855 G A 1 CED83406 X.sub.1522 M2 52 2258192 C T 2 CED83422 X.sub.1523 M2 52 2265219 C T 2 CED83425 X.sub.1524 M2 52 2266378 C T 3 CED83423 X.sub.1525 M2 52 2298758 G A 8 CED83435 X.sub.1526 M2 52 2308404 G T 3 CED83439 X.sub.1527 M2 52 2308421 T C 3 CED83439 X.sub.1528 M2 52 2327266 C T 3 CED83445 X.sub.1529 M2 52 2341484 C T 3 CED83451 X.sub.1530 M2 52 2373120 C T 2 CED83456 X.sub.1531 M2 52 2400778 C T 4 CED83463 X.sub.1532 M2 52 2443575 G A 2 CED83476 X.sub.1533 M2 52 2543220 C T 3 CED83509 X.sub.1534 M2 53 18836 T A 3 CDZ96344 X.sub.1535 M2 53 26291 G A 2 CDZ96348 X.sub.1536 M2 54 4815 G A 1 CDZ96384 X.sub.1537 M2 54 4816 A T 2 CDZ96384 X.sub.1538 M2 54 4817 G C 2 CDZ96384 X.sub.1539 M2 54 4821 G A 1 CDZ96384 X.sub.1540 M2 54 31207 G A 2 CDZ96392 X.sub.1541 M2 54 87947 G A 3 CDZ96410 X.sub.1542 M2 54 93810 G A 2 CDZ96414 X.sub.1543 M2 54 106086 G A 3 CDZ96416 X.sub.1544 M2 54 129380 C T 2 CDZ96423 X.sub.1545 M2 54 194230 G A 2 CDZ96446 X.sub.1546 M2 54 202467 C T 1 CDZ96448 X.sub.1547 M2 54 206494 G A 2 CDZ96450 X.sub.1548 M2 54 207737 C T 1 CDZ96450 X.sub.1549 M2 54 237973 C T 8 CDZ96461 X.sub.1550 M2 54 240326 G A 1 CDZ96462 X.sub.1551 M2 54 245840 G A 3 CDZ96464 X.sub.1552 M2 54 254295 C T 2 CDZ96465 X.sub.1553 M2 54 274617 A T 3 CDZ96471 X.sub.1554 M2 54 354688 C T 3 CDZ96493 X.sub.1555 M2 54 359671 G A 2 CDZ96496 X.sub.1556 M2 54 370320 G A 2 CDZ96499 X.sub.1557 M2 54 391223 A G 2 CDZ96509 X.sub.1558 M2 54 427542 C T 2 CDZ96520 X.sub.1559 M2 54 431851 C T 3 CDZ96520 X.sub.1560 M2 54 478527 C T 2 CDZ96537 X.sub.1561 M2 54 509857 G A 1 CDZ96544 X.sub.1562 M2 54 555986 G A 2 CDZ96563 X.sub.1563 M2 54 583996 G A 3 CDZ96570 X.sub.1564 M2 54 616268 A G 3 CDZ96581 X.sub.1565 M2 54 733193 T C 9 CDZ96619 X.sub.1566 M2 54 743396 G A 1 CDZ96621 X.sub.1567 M2 58 93 T C 6 X.sub.1568 M2 64 2113 G A 4 CDZ96626 X.sub.1569 M2 67 111 G A 6 X.sub.1570 M2 69 19892 A C 3 CED83533 X.sub.1571 M2 69 19893 G A 3 CED83533 X.sub.1572 M2 69 19917 T G 3 CED83533 X.sub.1573 M2 69 19920 T C 3 CED83533 X.sub.1574 M2 69 19926 A G 3 CED83533 X.sub.1575 M2 69 29006 G A 3 CED83534 X.sub.1576 M2 69 29188 C T 3 CED83534 X.sub.1577 M2 69 50642 C T 8 CED83543 X.sub.1578 M2 69 61047 C T 2 CED83547 X.sub.1579 M2 69 82710 G A 3 CED83554 X.sub.1580 M2 69 84820 G A 1 CED83555 X.sub.1581 M2 69 103317 C T 2 CED83559 X.sub.1582 M2 69 107920 C T 1 CED83561 X.sub.1583 M2 69 179873 C T 3 CED83585 X.sub.1584 M2 69 196810 G A 2 CED83594 X.sub.1585 M2 69 201005 G A 3 CED83595 X.sub.1586 M2 69 258091 G A 2 CED83614 X.sub.1587 M2 69 305997 C T 2 CED83631 X.sub.1588 M2 69 314003 C T 1 CED83634 X.sub.1589 M2 69 371916 C T 2 CED83653 X.sub.1590 M2 69 384418 G A 2 CED83656 X.sub.1591 M2 69 415659 C T 2 CED83665 X.sub.1592 M2 69 461986 G A 1 CED83680 X.sub.1593 M2 69 467686 C T 2 CED83681 X.sub.1594 M2 69 472563 C T 3 CED83681 X.sub.1595 M2 69 534495 C T 2 CED83704 X.sub.1596 M2 69 534506 C A 2 CED83704 X.sub.1597 M2 69 556138 C T 3 CED83710 X.sub.1598 M2 69 560348 G A 1 CED83713 X.sub.1599 M2 69 585845 G A 2 CED83722 X.sub.1600 M2 69 631511 G A 2 CED83742 X.sub.1601 M2 69 637299 T C 2 CED83744 X.sub.1602 M2 69 675579 G A 3 CED83760 X.sub.1603 M2 69 676581 G A 2 CED83760 X.sub.1604 M2 69 676853 G A 3 CED83759 X.sub.1605 M2 69 678406 C T 3 CED83759 X.sub.1606 M2 69 681141 G A 2 CED83762 X.sub.1607 M2 69 682770 C T 2 CED83763 X.sub.1608 M2 69 703602 C T 2 CED83770 X.sub.1609 M2 69 741255 C T 1 CED83781 X.sub.1610 M2 69 743019 C T 1 CED83782 X.sub.1611 M2 69 744021 C T 3 CED83780 X.sub.1612 M2 69 786726 C T 2 CED83794 X.sub.1613 M2 69 833538 A T 4 CED83805 X.sub.1614 M2 69 833558 C T 4 CED83805 X.sub.1615 M2 69 865820 C T 2 CED83814 X.sub.1616 M2 69 869706 G A 8 CED83815 X.sub.1617 M2 69 870338 G A 2 CED83815 X.sub.1618 M2 69 892199 G A 1 CED83822 X.sub.1619 M2 69 894019 G A 3 CED83821 X.sub.1620 M2 69 894462 C T 3 CED83821 X.sub.1621 M2 69 900223 G C 1 CED83824 X.sub.1622 M2 69 949982 C T 2 CED83842 X.sub.1623 M2 69 971219 C T 3 CED83847 X.sub.1624 M2 69 988364 G A 2 CED83857 X.sub.1625 M2 69 1042212 G A 2 CED83875 X.sub.1626 M2 69 1054397 C T 3 CED83879 X.sub.1627 M2 69 1080212 C T 3 CED83889 X.sub.1628 M2 69 1084824 G A 3 CED83891 X.sub.1629 M2 69 1084835 C T 3 CED83891 X.sub.1630 M2 69 1084848 A G 3 CED83891 X.sub.1631 M2 69 1084866 A G 3 CED83891 X.sub.1632 M2 69 1084931 C T 3 CED83891 X.sub.1633 M2 69 1089068 G A 2 CED83893 X.sub.1634 M2 69 1102164 C T 2 CED83897 X.sub.1635 M2 69 1105560 C T 2 CED83899 X.sub.1636 M2 69 1109785 C T 3 CED83899 X.sub.1637 M2 69 1109813 A G 3 CED83899 X.sub.1638 M2 69 1109818 A G 3 CED83899 X.sub.1639 M2 69 1109819 T A 3 CED83899 X.sub.1640 M2 69 1109823 T C 3 CED83899 X.sub.1641 M2 69 1109830 A G 3 CED83899 X.sub.1642 M2 69 1109831 C A 3 CED83899 X.sub.1643 M2 69 1109835 A G 3 CED83899 X.sub.1644 M2 69 1111789 C T 3 CED83899 X.sub.1645 M2 69 1115486 C T 2 CED83902 X.sub.1646 M2 69 1153118 G A 2 CED83915 X.sub.1647 M2 69 1161041 A G 1 CED83918 X.sub.1648 M2 69 1179032 G A 1 CED83923 X.sub.1649 M2 69 1199155 C T 8 CED83929 X.sub.1650 M2 69 1212727 G A 4 CED83933 X.sub.1651 M2 69 1218409 G A 3 CED83936 X.sub.1652 M2 69 1260087 G A 3 CED83949 X.sub.1653 M2 69 1327216 C A 5 CED83970 X.sub.1654 M2 69 1342909 G A 3 CED83975 X.sub.1655 M2 69 1411237 C T 1 CED84001 X.sub.1656 M2 69 1411421 C T 3 CED83999 X.sub.1657 M2 69 1430120 C T 2 CED84006 X.sub.1658 M2 69 1530586 C T 3 CED84038 X.sub.1659 M2 69 1590302 G A 1 CED84059 X.sub.1660 M2 69 1652288 C T 3 CED84077 X.sub.1661 M2 69 1674261 C T 1 CED84084 X.sub.1662 M2 69 1688555 C T 1 CED84088 X.sub.1663 M2 69 1706650 G A 8 CED84095 X.sub.1664 M2 69 1714728 G A 3 CED84097 X.sub.1665 M2 69 1735172 G A 2 CED84108 X.sub.1666 M2 69 1790823 C T 2 CED84125 X.sub.1667 M2 69 1792597 C T 2 CED84126 X.sub.1668 M2 69 1800584 G A 3 CED84129 X.sub.1669 M2 69 1803813 G A 3 CED84128 X.sub.1670 M2 69 1842064 C T 3 CED84140 X.sub.1671 M2 69 1854739 G A 3 CED84145 X.sub.1672 M2 69 1878663 C T 3 CED84154 X.sub.1673 M2 69 1924621 C T 3 CED84172 X.sub.1674 M2 69 1950597 C T 3 CED84182 X.sub.1675 M2 69 1957485 C T 2 CED84187 X.sub.1676 M2 69 1967529 C T 1 CED84189 X.sub.1677 M2 69 1968848 A G 3 CED84189 X.sub.1678 M2 69 2001469 C T 3 CED84197 X.sub.1679 M2 69 2009058 G A 8 CED84201 X.sub.1680 M2 69 2156050 C T 3 CED84252 X.sub.1681 M2 69 2160207 C T 1 CED84255 X.sub.1682 M2 69 2219444 G A 2 CED84271 X.sub.1683 M2 69 2226317 C T 2 CED84272 X.sub.1684 M2 69 2237950 C T 2 CED84276 X.sub.1685 M2 69 2255001 G A 2 CED84282 X.sub.1686 M2 69 2264484 G A 4 CED84284 X.sub.1687 M2 69 2275703 G A 2 CED84290 X.sub.1688 M2 69 2283903 G A 2 CED84293 X.sub.1689 M2 69 2348437 C T 2 CED84315 X.sub.1690 M2 69 2366082 C T 1 CED84318 X.sub.1691 M2 69 2368149 G A 2 CED84320 X.sub.1692 M2 69 2438727 C T 3 CED84343 X.sub.1693 M2 69 2439763 A G 3 CED84343 X.sub.1694 M2 69 2483433 G A 3 CED84352 X.sub.1695 M2 70 22 T C 6 A.sub.1696 M2 72 93 T C 6 X.sub.1697 M2 72 584 G A 6 X.sub.1698 M2 72 856 C T 6 X.sub.1699 M2 72 1163 C T 6 X.sub.1700 M2 73 174 C T 3 CDZ96628 X.sub.1701 M2 77 18912 A G 2 CDZ96635 X.sub.1702 M2 77 34978 G T 3 CDZ96642 X.sub.1703 M2 77 39665 G C 2 CDZ96646 X.sub.1704 M2 77 39842 G A 8 CDZ96646 X.sub.1705 M2 77 49497 G A 3 CDZ96648 X.sub.1706 M2 77 84022 G A 8 CDZ96659 X.sub.1707 M2 78 1865 C T 3 CED84359 X.sub.1708 M2 78 6333 G A 8 CED84360 X.sub.1709 M2 78 16110 C T 3 CED84363 X.sub.1710 M2 78 21716 C T 4 CED84364 X.sub.1711 M2 78 26915 C T 3 CED84366 X.sub.1712 M2 78 66886 G A 2 CED84381 X.sub.1713 M2 78 89958 C T 3 CED84387 X.sub.1714 M2 78 127873 G A 3 CED84395 X.sub.1715 M2 78 158434 G A 2 CED84406 X.sub.1716 M2 78 238854 C T 3 CED84430 X.sub.1717 M2 78 258716 A G 2 CED84437 X.sub.1718 M2 78 263828 T C 3 CED84438 X.sub.1719 M2 78 263896 T C 3 CED84438 X.sub.1720 M2 78 281454 C A 3 CED84441 X.sub.1721 M2 78 298141 C G 3 CED84443 X.sub.1722 M2 78 299644 G A 3 CED84443 X.sub.1723 M2 78 301815 T C 3 CED84443 X.sub.1724 M2 78 302816 T C 8 CED84443 X.sub.1725 M2 78 311576 G T 1 CED84447 X.sub.1726 M2 78 328831 C A 1 CED84450 X.sub.1727 M2 78 333312 A G m CED84452 X.sub.1728 M2 78 402094 T A 1 CED84476 X.sub.1729 M2 78 404944 G A 3 CED84475 X.sub.1730 M2 78 424723 A G 2 CED84482 X.sub.1731 M2 78 444292 C T 2 CED84490 X.sub.1732 M2 78 492399 C T 3 CED84504 X.sub.1733 M2 78 534530 C T 1 CED84520 X.sub.1734 M2 78 619735 T C 3 CED84547 X.sub.1735 M2 78 626958 C A 4 CED84549 X.sub.1736 M2 78 636848 C T 3 CED84551 X.sub.1737 M2 78 646777 C T 2 CED84556 X.sub.1738 M2 78 658932 G A 1 CED84561 X.sub.1739 M2 78 666005 C T 3 CED84562 X.sub.1740 M2 78 708376 C T 2 CED84580 X.sub.1741 M2 78 720093 G A 4 CED84583 X.sub.1742 M2 78 763771 G A 3 CED84600 X.sub.1743 M2 78 774252 G A 2 CED84602 X.sub.1744 M2 78 814066 T C 3 CED84613 X.sub.1745 M2 78 875825 C T 3 CED84633 X.sub.1746 M2 78 952815 G A 2 CED84662 X.sub.1747 M2 78 952860 G A 2 CED84662 X.sub.1748 M2 78 1023381 G A 2 CED84688 X.sub.1749 M2 78 1032138 G A 3 CED84693 X.sub.1750 M2 78 1066463 C T 2 CED84704 X.sub.1751 M2 78 1111002 G A 2 CED84721 X.sub.1752 M2 78 1115511 G A 1 CED84723 X.sub.1753 M2 78 1118856 C T 2 CED84724 X.sub.1754 M2 78 1142438 G A 2 CED84729 X.sub.1755 M2 78 1213556 G A 2 CED84752 X.sub.1756 M2 78 1216573 C T 1 CED84752 X.sub.1757 M2 78 1302286 C T 3 CED84782 X.sub.1758 M2 78 1315918 C T 3 CED84786 X.sub.1759 M2 78 1317124 G A 3 CED84787 X.sub.1760 M2 78 1344640 C T 3 CED84795 X.sub.1761 M2 78 1394095 T C 3 CED84815 X.sub.1762 M2 78 1426722 C T 2 CED84829 X.sub.1763 M2 78 1493542 C T 2 CED84851 X.sub.1764 M2 78 1495995 C T 1 CED84852 X.sub.1765 M2 78 1532973 G A 2 CED84857 X.sub.1766 M2 78 1568326 C T 2 CED84868 X.sub.1767 M2 78 1621099 C A 3 CED84883 X.sub.1768 M2 78 1642170 G A 3 CED84889 X.sub.1769 M2 78 1660408 G A 2 CED84897 X.sub.1770 M2 78 1694684 C T 2 CED84912 X.sub.1771 M2 78 1705462 G A 1 CED84915 X.sub.1772 M2 78 1721661 G A 3 CED84921 X.sub.1773 M2 78 1742796 G A 3 CED84926 X.sub.1774 M2 79 426 T C 1 CDZ96674 X.sub.1775 M2 79 473 T C 2 CDZ96674 X.sub.1776 M2 79 474 C T 1 CDZ96674 X.sub.1777 M2 79 47085 G A 3 CDZ96684 X.sub.1778 M2 79 57804 G A 2 CDZ96687 X.sub.1779 M2 79 64658 C T 3 CDZ96688 X.sub.1780 M2 79 65402 C T 3 CDZ96688 X.sub.1781 M2 79 86234 T C 3 CDZ96695 X.sub.1782 M2 79 132683 C T 2 CDZ96713 X.sub.1783 M2 79 147578 G A 2 CDZ96719 X.sub.1784 M2 79 168708 C T 8 CDZ96727 X.sub.1785 M2 79 171814 C T 3 CDZ96727 X.sub.1786 M2 79 243722 C T 1 CDZ96755 X.sub.1787 M2 79 281783 C T 2 CDZ96768 X.sub.1788 M2 79 296092 G A 1 CDZ96772 X.sub.1789 M2 79 307021 C T 3 CDZ96777 X.sub.1790 M2 79 318883 G A 3 CDZ96779 X.sub.1791 M2 79 346823 G A 2 CDZ96789 X.sub.1792 M2 79 406184 G A 3 CDZ96808 X.sub.1793 M2 79 412057 T C 1 CDZ96811 X.sub.1794 M2 79 412661 G A 2 CDZ96811 X.sub.1795 M2 79 430749 T C 3 CDZ96815 X.sub.1796 M2 79 480327 A C 2 CDZ96837 X.sub.1797 M2 79 492523 C T 3 CDZ96842 X.sub.1798 M2 79 573293 C T 3 CDZ96868 X.sub.1799 M2 79 575411 C T 3 CDZ96868 X.sub.1800 M2 79 579674 G A 1 CDZ96871 X.sub.1801 M2 79 617057 C T 2 CDZ96882 X.sub.1802 M2 79 679140 C T 2 CDZ96904 X.sub.1803 M2 79 686946 C T 3 CDZ96907 X.sub.1804 M2 79 696174 G A 4 CDZ96911 X.sub.1805 M2 79 702824 G A 3 CDZ96914 X.sub.1806 M2 79 702827 C T 3 CDZ96914 X.sub.1807 M2 79 735053 T C 3 CDZ96928 X.sub.1808 M2 79 747717 A G 3 CDZ96929 X.sub.1809 M2 79 758025 G A 3 CDZ96931 X.sub.1810 M2 79 759403 C T 3 CDZ96931 X.sub.1811 M2 79 759589 G A 4 CDZ96932 X.sub.1812 M2 79 759659 G A 2 CDZ96931 X.sub.1813 M2 79 760005 A G 4 CDZ96932 X.sub.1814 M2 79 760430 T C 2 CDZ96932 X.sub.1815 M2 79 760458 G T 1 CDZ96932 X.sub.1816 M2 79 760541 A G 2 CDZ96932 X.sub.1817 M2 79 760891 A G 2 CDZ96932 X.sub.1818 M2 79 760904 T C 2 CDZ96932 X.sub.1819 M2 79 760988 G T 2 CDZ96932 X.sub.1820 M2 79 761056 T C 3 CDZ96932 X.sub.1821 M2 79 761339 T G 3 CDZ96932 X.sub.1822 M2 79 761352 T A 3 CDZ96932 X.sub.1823 M2 79 761355 T C 3 CDZ96932 X.sub.1824 M2 79 768537 A G 4 CDZ96933 X.sub.1825 M2 79 776112 A G 4 CDZ96934 X.sub.1826 M2 79 776150 G A 4 CDZ96934 X.sub.1827 M2 79 780012 T C 4 CDZ96934 X.sub.1828 M2 79 786064 A G 3 CDZ96934 X.sub.1829 M2 79 798799 C T 1 CDZ96939 X.sub.1830 M2 79 914302 C T 3 CDZ96977 X.sub.1831 M2 79 922582 G A 1 CDZ96983 X.sub.1832 M2 79 933234 G A 3 CDZ96987 X.sub.1833 M2 79 973493 C T 4 CDZ97000 X.sub.1834 M2 79 995732 G A 1 CDZ97006 X.sub.1835 M2 79 1000786 A G 1 CDZ97007 X.sub.1836 M2 79 1021855 G A 3 CDZ97016 X.sub.1837 M2 79 1044652 G A 1 CDZ97023 X.sub.1838 M2 79 1052968 C T 3 CDZ97024 X.sub.1839 M2 79 1107695 C T 2 CDZ97046 X.sub.1840 M2 79 1123288 C T 2 CDZ97049 X.sub.1841 M2 79 1140763 G A 3 CDZ97053 X.sub.1842 M2 79 1149291 G A 3 CDZ97056 X.sub.1843 M2 79 1151678 C T 1 CDZ97060 X.sub.1844 M2 79 1209208 G A 3 CDZ97077 X.sub.1845 M2 79 1229129 G A 2 CDZ97086 X.sub.1846 M2 79 1231740 C T 2 CDZ97087 X.sub.1847 M2 79 1286163 T C 3 CDZ97106 X.sub.1848 M2 79 1287496 C T 1 CDZ97107 X.sub.1849 M2 79 1302166 G A 3 CDZ97112 X.sub.1850 M2 79 1318034 C T 1 CDZ97117 X.sub.1851 M2 79 1336766 C T 4 CDZ97121 X.sub.1852 M2 79 1387800 G A 3 CDZ97135 X.sub.1853 M2 79 1394034 G A 1 CDZ97137 X.sub.1854 M2 79 1430954 G A 2 CDZ97152 X.sub.1855 M2 79 1447480 G A 2 CDZ97156 X.sub.1856 M2 79 1471094 C T 3 CDZ97163 X.sub.1857 M2 79 1472351 C T 2 CDZ97165 X.sub.1858 M2 79 1540205 C T 2 CDZ97186 X.sub.1859 M2 79 1570526 C T 2 CDZ97198 X.sub.1860 M2 79 1624415 G A 1 CDZ97217 X.sub.1861 M2 79 1674448 G A 4 CDZ97228 X.sub.1862 M2 79 1694516 C T 3 CDZ97233 X.sub.1863 M2 79 1724009 G A 2 CDZ97243 X.sub.1864 M2 79 1788096 G A 2 CDZ97262 X.sub.1865 M2 79 1797660 C T 3 CDZ97265 X.sub.1866 M2 79 1797676 G A 3 CDZ97265 X.sub.1867 M2 79 1842448 G A 2 CDZ97282 X.sub.1868 M2 79 1842834 G A 2 CDZ97282 X.sub.1869 M2 79 1855037 A G 3 CDZ97285 X.sub.1870 M2 79 1855421 G A 3 CDZ97285 X.sub.1871 M2 79 1859220 A G 1 CDZ97291 X.sub.1872 M2 79 1869889 C T 3 CDZ97293 X.sub.1873 M2 79 1912360 G A 2 CDZ97307 X.sub.1874 M2 79 1977783 G A 3 CDZ97330 X.sub.1875 M2 79 2001789 C T 2 CDZ97339 X.sub.1876 M2 79 2002072 C T 1 CDZ97339 X.sub.1877 M2 79 2013361 C T 8 CDZ97344 X.sub.1878 M2 79 2024243 G A 2 CDZ97349 X.sub.1879 M2 79 2027861 C T 8 CDZ97350 X.sub.1880 M2 79 2066016 C T 1 CDZ97366 X.sub.1881 M2 79 2115870 G A 1 CDZ97380 X.sub.1882 M2 79 2121041 G A 3 CDZ97380 X.sub.1883 M2 79 2152573 C T 2 CDZ97392 X.sub.1884 M2 79 2187306 C T 3 CDZ97404 X.sub.1885 M2 79 2188410 G A 2 CDZ97405 X.sub.1886 M2 79 2268540 C T 1 CDZ97435 X.sub.1887 M2 79 2293228 C G 3 CDZ97442 X.sub.1888 M2 79 2317043 G A 1 CDZ97452 X.sub.1889 M2 79 2320060 G A 2 CDZ97454 X.sub.1890 M2 79 2323713 C T 2 CDZ97455 X.sub.1891 M2 79 2339881 C G 3 CDZ97460 X.sub.1892 M2 79 2340326 G A 3 CDZ97462 X.sub.1893 M2 79 2340636 T C 3 CDZ97462 X.sub.1894 M2 85 421 G A 6 X.sub.1895 M2 85 425 C T 6 X.sub.1896 M2 85 462 G A 6 X.sub.1897 M2 85 463 A G 6 X.sub.1898 M2 85 467 A T 6 X.sub.1899 M2 85 512 A G 6 X.sub.1900 M2 85 516 G A 6 X.sub.1901 M2 85 521 C T 6 X.sub.1902 M2 85 522 A G 6 X.sub.1903 M2 88 119 C T 3 CDZ97464 X.sub.1904 M2 88 196 G A 3 CDZ97464 X.sub.1905 M2 88 898 C T 4 CDZ97464 X.sub.1906 M2 99 245 G A 6 X.sub.1907 M2 103 768 C T 6 X.sub.1908 M2 106 278 A G 6 X.sub.1909 M2 109 396 T C 6 X.sub.1910 M2 115 361 G A 6 X.sub.1911 M2 118 396 C T 2 CDZ97478 X.sub.1912 M2 118 870 G A 4 CDZ97478 X.sub.1913 M2 118 1491 G A 4 CDZ97478 X.sub.1914 M2 121 907 T C 6 X.sub.1915 M2 121 1010 G A 6 X.sub.1916 M2 124 35211 G A 2 CDZ97488 X.sub.1917 M2 124 72117 G A 2 CDZ97501 X.sub.1918 M2 124 72760 G A 1 CDZ97501 X.sub.1919 M2 124 94611 G A 1 CDZ97507 X.sub.1920 M2 124 96777 C T 2 CDZ97508 X.sub.1921 M2 124 138045 C T 4 CDZ97519 X.sub.1922 M2 124 156052 G A 2 CDZ97524 X.sub.1923 M2 124 206541 G A 2 CDZ97541 X.sub.1924 M2 124 222249 C T 1 CDZ97547 X.sub.1925 M2 125 35864 T C 3 CDZ97573 X.sub.1926 M2 129 299 G A 3 CDZ97577 X.sub.1927 M2 129 433 G A 3 CDZ97577 X.sub.1928 M2 129 856 G A 2 CDZ97577 X.sub.1929 M2 129 1013 C T 1 CDZ97577 X.sub.1930 M2 130 674 C T 4 CDZ97578 X.sub.1931 M2 141 15764 C T 2 CDZ97587 X.sub.1932 M2 145 296 A G 6 X.sub.1933 M2 145 704 T G 6 X.sub.1934 M2 149 1663 A G 3 CDZ97598 X.sub.1935 M2 149 2074 T G 3 CDZ97598 X.sub.1936 M2 159 106 A C 6 X.sub.1937 M2 162 70405 A G 1 CDZ97625 X.sub.1938 M2 162 96194 G A 3 CDZ97631 X.sub.1939 M2 162 143415 G T 3 CDZ97647 X.sub.1940 M2 162 223407 C T 2 CDZ97674 X.sub.1941 M2 162 238126 C T 3 CDZ97680 X.sub.1942 M2 162 308369 T C 1 CDZ97702 X.sub.1943 M2 162 321070 C T 4 CDZ97703 X.sub.1944 M2 162 321073 A G 4 CDZ97703 X.sub.1945 M2 162 321460 C G 4 CDZ97703 X.sub.1946 M2 162 321463 A C 4 CDZ97703 X.sub.1947 M2 162 322591 G A 4 CDZ97703 X.sub.1948 M2 162 323473 C T 2 CDZ97703 X.sub.1949 M2 162 323480 T C 1 CDZ97703 X.sub.1950 M2 162 323735 A G 1 CDZ97703 X.sub.1951 M2 162 324114 T C 2 CDZ97703 X.sub.1952 M2 162 324139 C T 2 CDZ97703 X.sub.1953 M2 162 324568 A G 2 CDZ97703 X.sub.1954 M2 162 351016 C T 2 CDZ97711 X.sub.1955 M2 162 360320 G A 2 CDZ97714 X.sub.1956 M2 162 361986 T C 3 CDZ97714 X.sub.1957 M2 162 398165 C T 1 CDZ97730 X.sub.1958 M2 162 408274 C T 1 CDZ97733 X.sub.1959 M2 162 414579 C T 8 CDZ97737 X.sub.1960 M2 162 423180 C T 1 CDZ97740 X.sub.1961 M2 162 424391 C T 3 CDZ97740 X.sub.1962 M2 162 444123 T C 2 CDZ97748 X.sub.1963 M2 162 453998 G T 1 CDZ97751 X.sub.1964 M2 162 467207 C T 3 CDZ97755 X.sub.1965 M2 162 469139 G A 3 CDZ97757 X.sub.1966 M2 162 476928 C T 1 CDZ97760 X.sub.1967 M2 162 480722 G A 2 CDZ97761 X.sub.1968 M2 162 481093 G A 2 CDZ97761 X.sub.1969 M2 162 487433 G A 2 CDZ97763 X.sub.1970 M2 162 491906 G A 3 CDZ97764 X.sub.1971 M2 162 492101 G A 3 CDZ97764 X.sub.1972 M2 162 501886 C T 8 CDZ97769 X.sub.1973 M2 162 541612 G A 2 CDZ97784 X.sub.1974 M2 162 618658 C T 2 CDZ97808 X.sub.1975 M2 162 632311 G A 2 CDZ97814 X.sub.1976 M2 162 633321 G A 2 CDZ97814 X.sub.1977 M2 162 633633 G A 1 CDZ97814 X.sub.1978 M2 162 640005 C T 2 CDZ97815 X.sub.1979 M2 162 680645 G A 8 CDZ97826 X.sub.1980 M2 162 696331 T A 3 CDZ97828 X.sub.1981 M2 162 703725 G A 2 CDZ97831 X.sub.1982 M2 162 738675 G A 3 CDZ97842 X.sub.1983 M2 162 738686 C T 3 CDZ97842 X.sub.1984 M2 162 801198 C T 3 CDZ97864 X.sub.1985 M2 162 808830 G A 3 CDZ97869 X.sub.1986 M2 162 825209 G A 2 CDZ97877 X.sub.1987 M2 162 871911 C T 8 CDZ97890 X.sub.1988 M2 162 914850 C T 3 CDZ97904 X.sub.1989 M2 162 971882 G A 2 CDZ97924 X.sub.1990 M2 164 58 C T 6 X.sub.1991 M2 164 62 C T 6 X.sub.1992 M2 175 385 A C 6 X.sub.1993 M2 185 758 C T 4 CDZ97958 X.sub.1994 M2 189 1306 C T 3 CDZ97961 X.sub.1995 M2 189 58121 G A 3 CDZ97976 X.sub.1996 M2 189 88726 C T 1 CDZ97985 X.sub.1997 M2 189 108326 C T 3 CDZ97991 X.sub.1998 M2 189 126573 G A 3 CDZ97996 X.sub.1999 M2 189 142919 G T 4 CDZ98002 X.sub.2000 M2 189 194647 A G 3 CDZ98020 X.sub.2001 M2 189 194665 A G 3 CDZ98020 X.sub.2002 M2 189 212408 G A 2 CDZ98028 X.sub.2003 M2 189 257670 C T 1 CDZ98041 X.sub.2004 M2 189 274346 C T 3 CDZ98046 X.sub.2005 M2 189 298487 C T 1 CDZ98056 X.sub.2006 M2 189 323680 C T 2 CDZ98063 X.sub.2007 M2 189 328678 G T 3 CDZ98063 X.sub.2008 M2 189 332957 G A 3 CDZ98065 X.sub.2009 M2 189 371247 G A 5 CDZ98078 X.sub.2010 M2 189 400292 T C 3 CDZ98086 X.sub.2011 M2 191 342 A G 3 CDZ98107 X.sub.2012 M2 191 347 C T 3 CDZ98107 X.sub.2013 M2 191 427 C T 3 CDZ98107 X.sub.2014 M2 191 451 C T 3 CDZ98107 X.sub.2015 M2 191 487 A G 3 CDZ98107 X.sub.2016 M2 197 624 C T 3 CDZ98111 X.sub.2017 M2 198 202 C A 6 X.sub.2018 M2 198 203 G A 6 X.sub.2019 M2 198 238 C T 6 X.sub.2020 M2 198 265 C T 6 X.sub.2021 M2 198 452 G A 6 X.sub.2022 M2 199 688 C T 6 X.sub.2023 M2 199 911 C T 6 X.sub.2024 M2 199 971 C T 6 X.sub.2025 M2 199 1218 C T 6 X.sub.2026 M2 202 171 C T 6 X.sub.2027 M2 205 360 C T 3 CDZ98112 X.sub.2028 M2 205 981 C T 4 CDZ98112 X.sub.2029 M2 208 117 G A 6 X.sub.2030 M2 208 476 G A 6 X.sub.2031 M2 208 616 G A 6 X.sub.2032 M2 208 935 G A 6 X.sub.2033 M2 209 312 C T 8 CDZ98113 X.sub.2034 M2 223 93 G A 4 CDZ98118 X.sub.2035 M2 223 102 A G 4 CDZ98118 X.sub.2036 M2 223 133 A G 4 CDZ98118 X.sub.2037 M2 223 150 T C 4 CDZ98118 X.sub.2038 M2 223 155 A C 4 CDZ98118 X.sub.2039 M2 223 158 T C 4 CDZ98118 X.sub.2040 M2 223 160 C T 4 CDZ98118 X.sub.2041 M2 223 175 G A 4 CDZ98118 X.sub.2042 M2 223 177 A G 4 CDZ98118 X.sub.2043 M2 223 188 A G 4 CDZ98118 X.sub.2044 M2 223 192 C A 4 CDZ98118 X.sub.2045 M2 223 194 T C 4 CDZ98118 X.sub.2046 M2 223 195 T G 4 CDZ98118 X.sub.2047 M2 223 197 T C 4 CDZ98118 X.sub.2048 M2 223 202 G C 4 CDZ98118 X.sub.2049 M2 223 205 C T 4 CDZ98118 X.sub.2050 M2 223 360 C T 2 CDZ98118 X.sub.2051 M2 223 506 A G 7 CDZ98118 X.sub.2052 M2 223 519 T C 7 CDZ98118 X.sub.2053 M2 224 27 T A 6 X.sub.2054 M2 224 126 T C 6 X.sub.2055 M2 224 130 A 6 X.sub.2056 M2 225 317 C T 6 X.sub.2057 M2 227 202 G A 6 X.sub.2058 M2 229 225 G C 6 X.sub.2059 M2 232 340 G A 3 CDZ98119 X.sub.2060 M2 232 1379 C T 1 CDZ98119 X.sub.2061 M2 232 1521 C T 2 CDZ98119 X.sub.2062 M2 232 1662 G A 2 CDZ98119 X.sub.2063 M2 232 1761 C T 2 CDZ98119 X.sub.2064 M2 232 2027 C T 4 CDZ98119 X.sub.2065 M2 232 3060 C T 2 CDZ98120 X.sub.2066 M2 232 3284 C T 4 CDZ98119 X.sub.2067 M2 232 4437 G A 2 CDZ98121 X.sub.2068 M2 232 4561 C T 3 CDZ98120 X.sub.2069 M2 237 210 T C 6 X.sub.2070 M2 242 7334 C T 2 CDZ98125 X.sub.2071 M2 242 41710 G A 3 CDZ98131 X.sub.2072 M2 242 50262 G A 8 CDZ98135 X.sub.2073 M2 242 88037 G A 2 CDZ98147 X.sub.2074 M2 242 106805 G A 3 CDZ98152 X.sub.2075 M2 242 107587 G A 4 CDZ98153 X.sub.2076 M2 242 147104 G A 2 CDZ98164 X.sub.2077 M2 24 155049 C T 1 CDZ98168 X.sub.2078 M2 242 179344 A T 3 CDZ98173 X.sub.2079 M2 242 189498 G A 3 CDZ98176 X.sub.2080 M2 242 194983 C T 8 CDZ98179 X.sub.2081 M2 242 213399 C T 2 CDZ98185 X.sub.2082 M2 242 213986 G A 8 CDZ98185 X.sub.2083 M2 242 220015 G A 2 CDZ98187 X.sub.2084 M2 242 227271 C T 3 CDZ98191 X.sub.2085 M2 242 233088 G A 2 CDZ98193 X.sub.2086 M2 242 309675 G A 2 CDZ98216 X.sub.2087 M2 242 310353 G A 2 CDZ98216 X.sub.2088 M2 242 404132 G A 3 CDZ98248 X.sub.2089 M2 242 405825 G A 3 CDZ98250 X.sub.2090 M2 242 412676 G A 3 CDZ98249 X.sub.2091 M2 242 485936 G A 4 CDZ98270 X.sub.2092 M2 242 492389 G A 2 CDZ98274 X.sub.2093 M2 242 514780 C T 2 CDZ98282 X.sub.2094 M2 242 542663 G A 3 CDZ98290 X.sub.2095 M2 242 559999 G A 2 CDZ98297 X.sub.2096 M2 242 577367 G A 3 CDZ98302 X.sub.2097 M2 242 602456 G A 2 CDZ98308 X.sub.2098 M2 242 602531 G A 2 CDZ98308 X.sub.2099 M2 242 604704 C T 2 CDZ98309 X.sub.2100 M2 246 329 C G 2 CDZ98328 X.sub.2101 M2 246 331 T C 1 CDZ98328 X.sub.2102 M2 249 2757 C T CED84929 X.sub.2103 M2 249 2763 A T
CED84929 X.sub.2104 M2 249 42295 C T
CED84942 X.sub.2105 M2 249 72016 C T
CED84950 X.sub.2106 M2 249 104500 C T
CED84966 X.sub.2107 M2 249 110060 C T
CED84968 X.sub.2108 M2 249 142920 G A
CED84978 X.sub.2109 M2 249 157550 C T
CED84983 X.sub.2110 M2 249 191304 C T
CED84988 X.sub.2111 M2 249 239775 G A
CED85004 X.sub.2112 M2 249 272075 C T
CED85013 X.sub.2113 M2 249 289154 C T
CED85018 X.sub.2114 M2 249 294161 G A
CED85018 X.sub.2115 M2 249 294853 C T
CED85019 X.sub.2116 M2 249 305975 G A
CED85023 X.sub.2117 M2 249 326271 C T
CED85029 X.sub.2118 M2 249 376065 A G
CED85052 X.sub.2119 M2 249 381260 C T
CED85054 X.sub.2120 M2 249 390024 G A
CED85059 X.sub.2121 M2 249 412062 T C
CED85064 X.sub.2122 M2 249 469645 G A
CED85087 X.sub.2123 M2 249 485782 C T
CED85089 X.sub.2124 M2 249 487588 G A
CED85090 X.sub.2125 M2 249 500195 C T
CED85093 X.sub.2126 M2 249 501310 C T
CED85093 X.sub.2127 M2 249 501510 T C
CED85093 X.sub.2128 M2 249 532943 A G
CED85099 X.sub.2129 M2 249 561512 C A
CED85112 X.sub.2130 M2 249 561605 C T
CED85112 X.sub.2131 M2 249 568518 C T
CED85115 X.sub.2132 M2 249 598579 C T
CED85125 X.sub.2133 M2 249 626627 G A
CED85132 X.sub.2134 M2 249 637944 G A
CED85135 X.sub.2135 M2 249 657434 C T
CED85143 X.sub.2136 M2 249 660408 G A
CED85144 X.sub.2137 M2 249 662251 A T
CED85144 X.sub.2138 M2 249 746655 C T
CED85172 X.sub.2139 M2 249 772481 G A
CED85180 X.sub.2140 M2 249 849958 C T
CED85201 X.sub.2141 M2 249 854220 G A
CED85201 X.sub.2142 M2 249 911274 C T
CED85218 X.sub.2143 M2 249 927876 C T
CED85222 X.sub.2144 M2 249 932606 C T
CED85223 X.sub.2145 M2 249 945434 C T
CED85227 X.sub.2146 M2 249 945727 C T
CED85227 X.sub.2147 M2 249 969333 G T
CED85238 X.sub.2148 M2 249 972975 G A
CED85240 X.sub.2149 M2 249 977170 C T
CED85242 X.sub.2150 M2 249 989520 C T
CED85243 X.sub.2151 M2 249 1014098 C T
CED85252 X.sub.2152 M2 249 1050123 C T
CED85262 X.sub.2153 M2 249 1062282 G A
CED85266 X.sub.2154 M2 249 1063615 C T
CED85265 X.sub.2155 M2 249 1064359 C T
CED85265 X.sub.2156 M2 249 1067266 G A
CED85267 X.sub.2157 M2 249 1072127 C T
CED85268 X.sub.2158 M2 249 1076166 C T
CED85270 X.sub.2159 M2 249 1144309 G A
CED85291 X.sub.2160 M2 249 1176977 G A
CED85303 X.sub.2161 M2 249 1195367 G A
CED85307 X.sub.2162 M2 249 1203953 G A
CED85311 X.sub.2163 M2 249 1230068 C T
CED85319 X.sub.2164 M2 249 1234239 C T
CED85319 X.sub.2165 M2 249 1263893 C T
CED85327 X.sub.2166 M2 249 1286733 G A
CED85336 X.sub.2167 M2 249 1299472 C T
CED85343 X.sub.2168 M2 249 1305184 G A
CED85345 X.sub.2169 M2 249 1359399 G A
CED85360 X.sub.2170 M2 249 1457529 G A
CED85398 X.sub.2171 M2 249 1473930 C T
CED85404 X.sub.2172 M2 249 1473937 G A
CED85404 X.sub.2173 M2 249 1475200 G A
CED85404 X.sub.2174 M2 249 1475590 G A
CED85404 X.sub.2175 M2 249 1486325 G A
CED85409 X.sub.2176 M2 249 1498029 T C
CED85415 X.sub.2177 M2 249 1502631 G T
CED85416 X.sub.2178 M2 249 1502641 T A
CED85416 X.sub.2179 M2 249 1502819 T G
CED85416 X.sub.2180 M2 249 1505138 G A
CED85416 X.sub.2181 M2 249 1505634 T G
CED85416 X.sub.2182 M2 249 1507424 C T
CED85418 X.sub.2183 M2 249 1519431 A G
CED85419 X.sub.2184 M2 249 1520089 C T
CED85420 X.sub.2185 M2 249 1520565 C A
CED85420 X.sub.2186 M2 249 1520566 C T
CED85420 X.sub.2187 M2 249 1531574 C T
CED85423 X.sub.2188 M2 249 1555472 C T
CED85428 X.sub.2189 M2 249 1567124 G A
CED85432 X.sub.2190 M2 249 1619036 G A
CED85450 X.sub.2191 M2 249 1623151 G A
CED85451 X.sub.2192 M2 249 1653615 T G
CED85457 X.sub.2193 M2 249 1653962 C T
CED85458 X.sub.2194 M2 249 1679109 T A
CED85461 X.sub.2195 M2 249 1726777 C T
CED85474 X.sub.2196 M2 249 1734722 G A
CED85477 X.sub.2197 M2 249 1737431 C T
CED85478 X.sub.2198 M2 249 1780551 A G
CED85493 X.sub.2199 M2 249 1780569 A G
CED85493 X.sub.2200 M2 249 1801965 G A
CED85501 X.sub.2201 M2 249 1803575 C T
CED85502 X.sub.2202 M2 249 1804835 G A
CED85502 X.sub.2203 M2 249 1835770 G A
CED85509 X.sub.2204 M2 249 1862072 C T
CED85520 X.sub.2205 M2 249 1880762 G A
CED85525 X.sub.2206 M2 249 1902250 G T
CED85535 X.sub.2207 M2 249 1915336 C T
CED85537 X.sub.2208 M2 249 1944026 G A
CED85545 X.sub.2209 M2 249 1951259 G A
CED85547 X.sub.2210 M2 249 1988505 C T
CED85560 X.sub.2211 M2 249 2015272 G A
CED85567 X.sub.2212 M2 249 2027477 G A
CED85573 X.sub.2213 M2 249 2032298 C T
CED85575 X.sub.2214 M2 249 2054064 C T
CED85583 X.sub.2215 M2 249 2082550 A G
CED85591 X.sub.2216 M2 249 2110956 C T
CED85603 X.sub.2217 M2 249 2131353 C T
CED85609 X.sub.2218 M2 249 2147501 C T
CED85612 X.sub.2219 M2 249 2198205 G A
CED85628 X.sub.2220 M2 249 2223626 G A
CED85633 X.sub.2221 M2 249 2254072 G A
CED85640 X.sub.2222 M2 249 2255547 G C
CED85640 X.sub.2223 M2 251 1135 G A
X.sub.2224 M2 252 512 C T
X.sub.2225 M2 252 524 C T
X.sub.2226 M2 258 166 A G
X.sub.2227 M2 258 1139 A T
X.sub.2228 M2 258 1394 G A
X.sub.2229 M2 259 91 G C
X.sub.2230 M2 260 156 G A
X.sub.2231 M2 262 4049 G A
CDZ98330 X.sub.2232 M2 262 12289 C T
CDZ98333 X.sub.2233 M2 262 16863 C T
CDZ98334 X.sub.2234 M2 262 20959 G A
CDZ98336 X.sub.2235 M2 262 30347 G A
CDZ98338 X.sub.2236 M2 262 30359 G A
CDZ98338 X.sub.2237 M2 262 63941 G A
CDZ98349 X.sub.2238 M2 262 108865 C T
CDZ98369 X.sub.2239 M2 262 143387 C T
CDZ98375 X.sub.2240 M2 262 148151 C T
CDZ98375 X.sub.2241 M2 262 148199 G A
CDZ98376 X.sub.2242 M2 262 164438 G A
CDZ98383 X.sub.2243 M2 262 201531 G A
CDZ98396 X.sub.2244 M2 262 236880 G A
CDZ98406 X.sub.2245 M2 262 242371 C T
CDZ98411 X.sub.2246 M2 262 252708 G A
CDZ98414 X.sub.2247 M2 262 319302 G A
CDZ98436 X.sub.2248 M2 262 345538 C T
CDZ98448 X.sub.2249 M2 262 350852 C T
CDZ98449 X.sub.2250 M2 262 380519 C T
CDZ98457 X.sub.2251 M2 262 397539 G A
CDZ98463 X.sub.2252 M2 262 414403 C T
CDZ98467 X.sub.2253 M2 262 420102 G A
CDZ98468 X.sub.2254 M2 262 444331 G A
CDZ98477 X.sub.2255 M2 262 446956 C T
CDZ98477 X.sub.2256 M2 262 510643 G A
CDZ98502 X.sub.2257 M2 262 525946 C T
CDZ98509 X.sub.2258 M2 262 539428 G A
CDZ98514 X.sub.2259 M2 262 539452 A G
CDZ98514 X.sub.2260 M2 262 539470 A G
CDZ98514 X.sub.2261 M2 262 539588 A G
CDZ98514 X.sub.2262 M2 262 552414 C T
CDZ98518 X.sub.2263 M2 262 557280 G A
CDZ98518 X.sub.2264 M2 262 560713 G A
CDZ98519 X.sub.2265 M2 262 562795 C T
CDZ98521 X.sub.2266 M2 262 567591 G A
CDZ98524 X.sub.2267 M2 262 567801 G A
CDZ98524 X.sub.2268 M2 262 618198 G A
CDZ98538 X.sub.2269 M2 262 638804 G C
CDZ98544 X.sub.2270 M2 262 638986 C G
CDZ98544 X.sub.2271 M2 262 639006 C T
CDZ98544 X.sub.2272 M2 262 639962 A G
CDZ98544 X.sub.2273 M2 262 640066 A G
CDZ98544 X.sub.2274 M2 262 655754 A T
CDZ98545 X.sub.2275 M2 262 655757 T C
CDZ98545 X.sub.2276 M2 262 656031 C A
CDZ98545 X.sub.2277 M2 262 656323 C G
CDZ98545 X.sub.2278 M2 262 668764 C T
CDZ98545 X.sub.2279 M2 262 691577 C T
CDZ98551 X.sub.2280 M2 262 729852 G A
CDZ98564 X.sub.2281 M2 262 751209 C T
CDZ98572 X.sub.2282 M2 262 801626 G A
CDZ98589 X.sub.2283 M2 262 822734 G A
CDZ98597 X.sub.2284 M2 262 825723 A G
CDZ98598 X.sub.2285 M2 262 835874 C T
CDZ98601 X.sub.2286 M2 262 856616 G A
CDZ98612 X.sub.2287 M2 262 865999 G A
CDZ98613 X.sub.2288 M2 262 882258 G A
CDZ98619 X.sub.2289 M2 262 971713 G A
CDZ98649 X.sub.2290 M2 262 976074 C T
CDZ98650 X.sub.2291 M2 262 1011054 G A
CDZ98659 X.sub.2292 M2 262 1044256 G A
CDZ98669 X.sub.2293 M2 262 1051389 C T
CDZ98670 X.sub.2294 M2 262 1209662 G A
CDZ98723 X.sub.2295 M2 262 1225705 C T
CDZ98730 X.sub.2296 M2 262 1226072 C T
CDZ98730 X.sub.2297 M2 262 1229407 G A
CDZ98732 X.sub.2298 M2 262 1277604 G A
CDZ98747 X.sub.2299 M2 262 1284428 G A
CDZ98748 X.sub.2300 M2 262 1305361 G A
CDZ98753 X.sub.2301 M2 262 1329643 C T
CDZ98760 X.sub.2302 M2 262 1332176 C T
CDZ98761 X.sub.2303 M2 262 1339924 C T
CDZ98763 X.sub.2304 M2 262 1351116 A G
CDZ98766 X.sub.2305 M2 262 1367361 C T
CDZ98772 X.sub.2306 M2 262 1408928 G A
CDZ98786 X.sub.2307 M2 262 1424293 G A
CDZ98791 X.sub.2308 M2 262 1455677 G A
CDZ98804 X.sub.2309 M2 262 1546246 C T
CDZ98833 X.sub.2310 M2 262 1550311 C T
CDZ98836 X.sub.2311 M2 262 1550456 C T
CDZ98837 X.sub.2312 M2 262 1615762 G A
CDZ98855 X.sub.2313 M2 262 1677620 G A
CDZ98873 X.sub.2314 M2 262 1694625 C T
CDZ98878 X.sub.2315 M2 262 1700623 A T
CDZ98883 X.sub.2316 M2 262 1716385 G A
CDZ98887 X.sub.2317 M2 266 85 C T
X.sub.2318 M2 266 252 C T
X.sub.2319 M2 267 93 G A
X.sub.2320 M2 267 94 A G
X.sub.2321 M2 267 133 T C
X.sub.2322 M2 267 134 C T
X.sub.2323 M2 267 201 T C
X.sub.2324 M2 267 208 T C
X.sub.2325 M2 267 237 T G
X.sub.2326 M2 267 254 G T
X.sub.2327 M2 267 256 A G
X.sub.2328 M2 267 257 T C
X.sub.2329 M3 22 1643 C T
CED80056 X.sub.2330 M3 22 2524 G A
CED80056 X.sub.2331 M3 28 236 G A
CDZ96150 X.sub.2332 M3 28 377 G A
CDZ96150 X.sub.2333 M3 28 1506 C T
CDZ96150 X.sub.2334 M3 28 1677 C T
CDZ96150 X.sub.2335 M3 43 464 G A
CDZ96151 X.sub.2336 M3 43 753 C T
CDZ96151 X.sub.2337 M3 43 757 G A
CDZ96151 X.sub.2338 M3 43 1527 C T
CDZ96151 X.sub.2339 M3 43 1748 G A
CDZ96151 X.sub.2340 M3 43 1928 C T
CDZ96151 X.sub.2341 M3 62 26 T A
CDZ96152 X.sub.2342 M3 62 27 T C
CDZ96152 X.sub.2343 M3 62 55 T A
CDZ96152 X.sub.2344 M3 62 403 C T
CDZ96152 X.sub.2345 M3 62 875 G A
CDZ96152 X.sub.2346 M3 102 339 C T
CDZ96153 X.sub.2347 M3 102 951 G A
CDZ96153 X.sub.2348 M3 102 1042 G A
CDZ96153 X.sub.2349 M3 102 2334 G A
CDZ96153 X.sub.2350 M3 102 2590 C T
CDZ96153 X.sub.2351 M3 102 3427 C T
CDZ96153 X.sub.2352 M3 176 358 G A
CED80058 X.sub.2353 M3 176 1872 G A
CED80058 X.sub.2354 M3 176 1980 G A
CED80058 X.sub.2355 M3 179 93 A G
CDZ96154 X.sub.2356 M3 179 96 G A
CDZ96154 X.sub.2357 M3 179 1525 G A
CDZ96154 X.sub.2358 M3 179 1780 C T
CDZ96154 X.sub.2359 M3 188 815 C T
CED80060 X.sub.2360 M3 188 1174 C T
CED80060 X.sub.2361 M3 188 2163 G A
CED80060 X.sub.2362 M3 188 2170 G A
CED80060 X.sub.2363 M3 188 2250 C T
CED80060 X.sub.2364 M3 247 102 G A
CED80061 X.sub.2365 M3 247 989 C T
CED80061 X.sub.2366 M3 247 1053 G A
CED80061 X.sub.2367 M3 4 781 G A
X.sub.2368 M3 7 160 T C
X.sub.2369 M3 8 1110 C T
X.sub.2370 M3 11 154 A C
X.sub.2371 M3 11 158 C T
X.sub.2372 M3 13 559 C T
CDZ96158 X.sub.2373 M3 15 183 C T
X.sub.2374 M3 24 513 T C
CDZ96160 X.sub.2375 M3 24 520 C G
CDZ96160 X.sub.2376 M3 24 5850 C T
CDZ96160 X.sub.2377 M3 24 169574 C T
CDZ96213 X.sub.2378 M3 24 172698 G A
CDZ96215 X.sub.2379 M3 24 180340 G A
CDZ96216 X.sub.2380 M3 24 216696 C T
CDZ96228 X.sub.2381 M3 24 266697 G A
CDZ96242 X.sub.2382 M3 24 307114 G A
CDZ96255 X.sub.2383 M3 24 340626 C T
CDZ96265 X.sub.2384 M3 24 340663 T C
CDZ96265 X.sub.2385 M3 24 400418 C T
CDZ96287 X.sub.2385 M3 24 420108 G A
CDZ96291 X.sub.2387 M3 25 622 G A
X.sub.2388 M3 27 445 C T
X.sub.2389 M3 27 1012 A C
X.sub.2390 M3 27 1013 T A
X.sub.2391 M3 32 158 C T
CDZ96332 X.sub.2392 M3 32 215 C T
CDZ96332 X.sub.2393 M3 32 2438 C T
CDZ96332 X.sub.2394 M3 32 2734 C T
CDZ96332 X.sub.2395 M3 32 2821 C T
CDZ96332 X.sub.2396 M3 32 3067 C T
CDZ96332 X.sub.2397 M3 32 3506 C T
CDZ96332 X.sub.2398 M3 32 3562 G A
CDZ96332 X.sub.2399 M3 33 399 T A
CED82002 X.sub.2400 M3 33 45488 C T
CED82012 X.sub.2401 M3 33 79913 G A
CED82024 X.sub.2402 M3 33 109397 G A
CED82038 X.sub.2403 M3 33 129733 G A
CED82045 X.sub.2404 M3 33 257786 C T
CED82084 X.sub.2405 M3 33 260027 G A
CED82084 X.sub.2406 M3 33 274627 G A
CED82091 X.sub.2407 M3 33 283808 C T
CED82093 X.sub.2408 M3 33 326016 T C
CED82108 X.sub.2409 M3 33 327840 C T
CED82108 X.sub.2410 M3 33 341890 G A
CED82113 X.sub.2411 M3 33 370630 A T
CED82121- CED82122 X.sub.2412 M3 33 371277 G A
CED82121- CED82122 X.sub.2413 M3 33 374131 A G
CED82121- CED82122 X.sub.2414 M3 33 374134 A G
CED82121- CED82122 X.sub.2415 M3 33 374137 A T
CED82121- CED82122 X.sub.2416 M3 33 374150 A C
CED82121- CED82122 X.sub.2417 M3 33 375339 A G
CED82121- CED82122 X.sub.2418 M3 33 375366 T C
CED82121- CED82122 X.sub.2419 M3 33 382577 C T
CED82122 X.sub.2420 M3 33 385319 A C
CED82122 X.sub.2421 M3 33 385527 C T
CED82122 X.sub.2422 M3 33 428329 G A
CED82136 X.sub.2423 M3 33 448815 G A
CED82144 X.sub.2424 M3 33 455451 C T
CED82146 X.sub.2425 M3 33 505339 C T
CED82165 X.sub.2426 M3 33 509127 C T
CED82166 X.sub.2427 M3 33 556726 C T
CED82183 X.sub.2428 M3 33 626521 C T
CED82203 X.sub.2429 M3 33 628247 C T
CED82205 X.sub.2430 M3 33 639242 G A
CED82208 X.sub.2431 M3 33 643436 G A
CED82208 X.sub.2432 M3 33 699423 C T
CED82227 X.sub.2433 M3 33 715901 C T
CED82231 X.sub.2434 M3 33 729705 C T
CED82234 X.sub.2435 M3 33 792965 G A
CED82256 X.sub.2436 M3 33 829825 C T
CED82271 X.sub.2437 M3 33 917771 A T
CED82294 X.sub.2438 M3 33 928554 A T
CED82297 X.sub.2439 M3 33 936350 T A
CED82300 X.sub.2440 M3 33 936356 G A
CED82300 X.sub.2441 M3 33 936571 A G
CED82300 X.sub.2442 M3 33 936600 G A
CED82300 X.sub.2443 M3 33 936697 A G
CED82300 X.sub.2444 M3 33 944373 G A
CED82301 X.sub.2445 M3 33 995886 G A
CED82318 X.sub.2446 M3 33 1049699 G A
CED82334 X.sub.2447 M3 33 1051104 G A
CED82334 X.sub.2448 M3 33 1086609 G A
CED82349 X.sub.2449 M3 33 1138444 C T
CED82363 X.sub.2450 M3 33 1165914 G A
CED82372 X.sub.2451 M3 33 1191727 C T
CED82379 X.sub.2452 M3 33 1246468 C T
CED82392 X.sub.2453 M3 33 1311181 G A
CED82413 X.sub.2454 M3 33 1324395 G A
CED82417 X.sub.2455 M3 33 1333932 G A
CED82421 X.sub.2456 M3 33 1339376 C T
CED82424 X.sub.2457 M3 33 1396438 C T
CED82442 X.sub.2458 M3 33 1467702 C T
CED82463 X.sub.2459 M3 33 1468155 G A
CED82464 X.sub.2460 M3 33 1474577 G A
CED82466 X.sub.2461 M3 33 1480984 G A
CED82466 X.sub.2462 M3 33 1499347 G A
CED82472 X.sub.2463 M3 33 1537493 C A
CED82485 X.sub.2464 M3 33 1544767 A C
CED82485- CED82486 X.sub.2465 M3 33 1544951 C G
CED82485- CED82486 X.sub.2466 M3 33 1572498 C T
CED82491 X.sub.2467 M3 33 1587443 C T
CED82497 X.sub.2468 M3 33 1596242 C T
CED82498 X.sub.2469 M3 33 1628197 G A
CED82510 X.sub.2470 M3 33 1628812 C T
CED82510 X.sub.2471 M3 33 1638726 G A
CED82513 X.sub.2472 M3 33 1642659 G A
CED82515 X.sub.2473 M3 33 1666039 G A
CED82521 X.sub.2474 M3 33 1682149 C T
CED82526 X.sub.2475 M3 33 1689192 C T
CED82529 X.sub.2476 M3 33 1700000 G A
CED82534 X.sub.2477 M3 33 1723348 C T
CED82539 X.sub.2478 M3 33 1728730 G A
CED82541 X.sub.2479 M3 33 1740595 C T
CED82545 X.sub.2480 M3 33 1780044 G A
CED82555 X.sub.2481 M3 33 1819902 C T
CED82571 X.sub.2482 M3 33 1823362 C T
CED82571 X.sub.2483 M3 33 1826223 G A
CED82573 X.sub.2484 M3 33 1841263 G A
CED82576 X.sub.2485 M3 33 1848935 C T
CED82579 X.sub.2486 M3 33 1861019 G A
CED82583 X.sub.2487 M3 33 1881896 T C
CED82588 X.sub.2488 M3 33 1886315 G A
CED82591 X.sub.2489 M3 33 1887401 C T
CED82591 X.sub.2490 M3 33 1888706 C T
CED82592 X.sub.2491 M3 33 1939670 C T
CED82612 X.sub.2492 M3 33 1950090 G A
CED82614 X.sub.2493 M3 33 1959142 G A
CED82619 X.sub.2494 M3 33 1975079 G A
CED82625 X.sub.2495 M3 33 2010230 C T
CED82636 X.sub.2496 M3 33 2014477 C T
CED82637 X.sub.2497 M3 33 2044014 G A
CED82647 X.sub.2498 M3 33 2050847 G A
CED82651 X.sub.2499 M3 36 320 G A
X.sub.2500 M3 36 1056 G A
X.sub.2501 M3 36 1295 C T
X.sub.2502 M3 36 1461 A T
X.sub.2503 M3 42 804 C T
CDZ96333 X.sub.2504 M3 42 1559 G A
CDZ96333 X.sub.2505 M3 48 563 C T
X.sub.2506 M3 48 565 T C
X.sub.2507 M3 48 576 G A
X.sub.2508 M3 48 580 T A
X.sub.2509 M3 50 145 G A
X.sub.2510 M3 52 3042 A G
CED82664 X.sub.2511 M3 52 63772 C T
CED82686 X.sub.2512 M3 52 63859 C T
CED82686 X.sub.2513 M3 52 123705 C T
CED82700 X.sub.2514 M3 52 128353 G A
CED82702 X.sub.2515 M3 52 144382 C T
CED82709 X.sub.2516 M3 52 151974 C T
CED82712 X.sub.2517 M3 52 183986 C T
CED82722 X.sub.2518 M3 52 207354 C T
CED82730 X.sub.2519 M3 52 211602 G A
CED82730 X.sub.2520 M3 52 223289 A G
CED82732- CED82733 X.sub.2521 M3 52 240075 G C
CED82734 X.sub.2522 M3 52 244305 G A
CED82734 X.sub.2523 M3 52 284733 G A
CED82747 X.sub.2524 M3 52 390095 G A
CED82784 X.sub.2525 M3 52 395374 G A
CED82786 X.sub.2526 M3 52 398723 C T
CED82786 X.sub.2527 M3 52 398728 C T
CED82786 X.sub.2528 M3 52 422792 C T
CED82794 X.sub.2529 M3 52 516267 C T
CED82823 X.sub.2530 M3 52 542542 C T
CED82833 X.sub.2531 M3 52 548788 G A
CED82835 X.sub.2532 M3 52 552099 G A
CED82837 X.sub.2533 M3 52 552173 G A
CED82837 X.sub.2534 M3 52 571124 G A
CED82845 X.sub.2535 M3 52 631479 C T
CED82860 X.sub.2536 M3 52 638622 G A
CED82862 X.sub.2537 M3 52 725138 C T
CED82899 X.sub.2538 M3 52 737403 G A
CED82903 X.sub.2539 M3 52 737419 G A
CED82903 X.sub.2540 M3 52 809156 C T
CED82928 X.sub.2541 M3 52 817452 T A
CED82928 X.sub.2542 M3 52 826846 G A
CED82931 X.sub.2543 M3 52 840755 C T
CED82935 X.sub.2544 M3 52 849671 G A
CED82940 X.sub.2545 M3 52 890412 C T
CED82956 X.sub.2546 M3 52 938650 G A
CED82973 X.sub.2547 M3 52 967316 A T
CED82984 X.sub.2548 M3 52 967701 T A
CED82983 X.sub.2549 M3 52 1001035 G A
CED82999 X.sub.2550 M3 52 1001299 C T
CED82998 X.sub.2551 M3 52 1003899 G A
CED83001 X.sub.2552 M3 52 1004724 G A
CED83001 X.sub.2553 M3 52 1029498 G A
CED83007 X.sub.2554 M3 52 1043011 C T
CED83012 X.sub.2555 M3 52 1067895 C T
CED83020 X.sub.2556 M3 52 1151398 G A
CED83046 X.sub.2557 M3 52 1158103 C T
CED83051 X.sub.2558 M3 52 1163067 G A
CED83051 X.sub.2559 M3 52 1219894 C T
CED83071 X.sub.2560 M3 52 1247924 C T
CED83081 X.sub.2561 M3 52 1291646 C T
CED83098 X.sub.2562 M3 52 1363357 G A
CED83122 X.sub.2563 M3 52 1363405 C T
CED83123 X.sub.2564 M3 52 1389320 G A
CED83130 X.sub.2565 M3 52 1399439 G A
CED83134 X.sub.2566 M3 52 1458571 C T
CED83158 X.sub.2567 M3 52 1474412 G A
CED83166 X.sub.2568 M3 52 1475408 C T
CED83166 X.sub.2569 M3 52 1509004 G A
CED83177 X.sub.2570 M3 52 1526796 G A
CED83181 X.sub.2571 M3 52 1570053 C T
CED83200 X.sub.2572 M3 52 1583655 C T
CED83206 X.sub.2573 M3 52 1688685 C T
CED83243 X.sub.2574 M3 52 1708900 A G
CED83249 X.sub.2575 M3 52 1708985 C T
CED83248 X.sub.2576 M3 52 1715136 C T
CED83250 X.sub.2577 M3 52 1716210 C T
CED83250 X.sub.2578 M3 52 1760440 G A
CED83266 X.sub.2579 M3 52 1793370 G A
CED83275 X.sub.2580 M3 52 1807309 G A
CED83283 X.sub.2581 M3 52 1871310 C T
CED83304 X.sub.2582 M3 52 1874150 G T
CED83305 X.sub.2583 M3 52 1874531 C T
CED83306 X.sub.2584 M3 52 1893352 G A
CED83313 X.sub.2585 M3 52 1987096 G A
CED83341 X.sub.2586 M3 52 1995167 G A
CED83342 X.sub.2587 M3 52 2041781 C T
CED83355 X.sub.2588 M3 52 2048018 G A
CED83358 X.sub.2589 M3 52 2050245 G A
CED83359 X.sub.2590 M3 52 2081390 G A
CED83367 X.sub.2591 M3 52 2093251 C T
CED83368 X.sub.2592 M3 52 2120665 C T
CED83376 X.sub.2593 M3 52 2136885 A G
CED83382 X.sub.2594 M3 52 2162878 G A
CED83392 X.sub.2595 M3 52 2178340 G A
CED83397 X.sub.2596 M3 52 2258192 C T
CED83422 X.sub.2597 M3 52 2265219 C T
CED83425 X.sub.2598 M3 52 2266378 C T
CED83423 X.sub.2599 M3 52 2266753 C T
CED83426 X.sub.2600 M3 52 2327266 C T
CED83445 X.sub.2601 M3 52 2338728 G A
CED83451 X.sub.2602 M3 52 2341484 C T
CED83451 X.sub.2603 M3 52 2364315 G A
CED83455 X.sub.2604 M3 52 2367582 G A
CED83455 X.sub.2605 M3 52 2373120 C T
CED83456 X.sub.2606 M3 52 2373426 G A
CED83456 X.sub.2607 M3 52 2373448 C T
CED83456 X.sub.2608 M3 52 2400778 C T
CED83463 X.sub.2609 M3 52 2488746 G A
CED83493 X.sub.2610 M3 52 2531584 C T
CED83507 X.sub.2611 M3 52 2543220 C T
CED83509 X.sub.2612 M3 53 26291 G A
CDZ96348 X.sub.2613 M3 53 55702 C T
CDZ96359 X.sub.2614 M3 53 69664 C T
CDZ96363 X.sub.2615 M3 53 110192 C T
CDZ96376 X.sub.2616 M3 54 4815 G A
CDZ96384 X.sub.2617 M3 54 4816 A T
CDZ96384 X.sub.2618 M3 54 4817 G C
CDZ96384 X.sub.2619 M3 54 4821 G A
CDZ96384 X.sub.2620 M3 54 16963 C T
CDZ96386 X.sub.2621 M3 54 60769 G A
CDZ96403 X.sub.2622 M3 54 72235 G A
CDZ96406 X.sub.2623 M3 54 87947 G A
CDZ96410 X.sub.2624 M3 54 106086 G A
CDZ96416 X.sub.2625 M3 54 114442 G A
CDZ96419 X.sub.2626 M3 54 119439 C T
CDZ96420 X.sub.2627 M3 54 142211 A G
CDZ96426 X.sub.2628 M3 54 194230 G A
CDZ96446 X.sub.2629 M3 54 202467 C T
CDZ96448 X.sub.2630 M3 54 206494 G A
CDZ96450 X.sub.2631 M3 54 222860 G A
CDZ96456 X.sub.2632 M3 54 258379 G A
CDZ96465 X.sub.2633 M3 54 274617 A T
CDZ96471 X.sub.2634 M3 54 296381 G A
CDZ96481 X.sub.2635 M3 54 316790 T G
CDZ96487 X.sub.2636 M3 54 357141 G A
CDZ96496 X.sub.2637 M3 54 370320 G A
CDZ96499 X.sub.2638 M3 54 391223 A G
CDZ96509 X.sub.2639 M3 54 402099 G A
CDZ96511 X.sub.2640 M3 54 404968 C T
CDZ96513 X.sub.2641 M3 54 407871 T A
CDZ96515 X.sub.2642 M3 54 413765 G A
CDZ96516 X.sub.2643 M3 54 427542 C T
CDZ96520 X.sub.2644 M3 54 431851 C T
CDZ96520 X.sub.2645 M3 54 478527 C T
CDZ96537 X.sub.2646 M3 54 509857 G A
CDZ96544 X.sub.2647 M3 54 537282 T C
CDZ96557 X.sub.2648 M3 54 576174 G A
CDZ96569 X.sub.2649 M3 54 616268 A G
CDZ96581 X.sub.2650 M3 54 647579 C T
CDZ96590 X.sub.2651 M3 54 733193 T C
CDZ96619 X.sub.2652 M3 54 743396 G A
CDZ96621 X.sub.2653 M3 54 746707 G A
CDZ96623 X.sub.2654 M3 58 93 T C
X.sub.2655 M3 64 2756 A C
CDZ96626 X.sub.2656 M3 64 2767 G A
CDZ96626 X.sub.2657 M3 64 2770 C T
CDZ96626 X.sub.2658 M3 64 2783 C T
CDZ96626 X.sub.2659 M3 67 111 G A
X.sub.2660 M3 69 29006 G A
CED83534 X.sub.2661 M3 69 52428 G A
CED83541 X.sub.2662 M3 69 82710 G A
CED83554 X.sub.2663 M3 69 107920 C T
CED83561 X.sub.2664 M3 69 148757 C T
CED83575 X.sub.2665 M3 69 201005 G A
CED83595 X.sub.2666 M3 69 201961 G A
CED83597 X.sub.2667 M3 69 258091 G A
CED83614 X.sub.2668 M3 69 314003 C T
CED83634 X.sub.2669 M3 69 371916 C T
CED83653 X.sub.2670 M3 69 384418 G A
CED83656 X.sub.2671 M3 69 415659 C T
CED83665 X.sub.2672 M3 69 431248 G A
CED83671 X.sub.2673 M3 69 461986 G A
CED83680 X.sub.2674 M3 69 585845 G A
CED83722 X.sub.2675 M3 69 631511 G A
CED83742 X.sub.2676 M3 69 637299 T C
CED83744 X.sub.2677 M3 69 638135 G A
CED83744 X.sub.2678 M3 69 675579 G A
CED83760 X.sub.2679 M3 69 676581 G A
CED83760 X.sub.2680 M3 69 676853 G A
CED83759 X.sub.2681 M3 69 678406 C T
CED83759 X.sub.2682 M3 69 777063 G A
CED83792 X.sub.2683 M3 69 803358 G A
CED83798 X.sub.2684 M3 69 865820 C T
CED83814 X.sub.2685 M3 69 869706 G A
CED83815 X.sub.2686 M3 69 870338 G A
CED83815 X.sub.2687 M3 69 892199 G A
CED83822 X.sub.2688 M3 69 894462 C T
CED83821 X.sub.2689 M3 69 898044 C T
CED83823 X.sub.2690 M3 69 949982 C T
CED83842 X.sub.2691 M3 69 971219 C T
CED83847 X.sub.2692 M3 69 988364 G A
CED83857 X.sub.2693 M3 69 989781 G A
CED83858 X.sub.2694 M3 69 1021695 G A
CED83868 X.sub.2695 M3 69 1042212 G A
CED83875 X.sub.2696 M3 69 1054397 C T
CED83879 X.sub.2697 M3 69 1084824 G A
CED83891 X.sub.2698 M3 69 1084835 C T
CED83891 X.sub.2699 M3 69 1084848 A G
CED83891 X.sub.2700 M3 69 1084866 A G
CED83891 X.sub.2701 M3 69 1084931 C T
CED83891 X.sub.2702 M3 69 1102164 C T
CED83897 X.sub.2703 M3 69 1109785 C T
CED83899 X.sub.2704 M3 69 1109813 A G
CED83899 X.sub.2705 M3 69 1109818 A G
CED83899 X.sub.2706 M3 69 1109819 T A
CED83899 X.sub.2707 M3 69 1109823 T C
CED83899 X.sub.2708 M3 69 1109830 A G
CED83899 X.sub.2709 M3 69 1109831 C A
CED83899 X.sub.2710 M3 69 1109835 A G
CED83899 X.sub.2711 M3 69 1192333 G A
CED83928 X.sub.2712 M3 69 1199155 C T
CED83929 X.sub.2713 M3 69 1218409 G A
CED83936 X.sub.2714 M3 69 1260087 G A
CED83949 X.sub.2715 M3 69 1342909 G A
CED83975 X.sub.2716 M3 69 1411237 C T
CED84001 X.sub.2717 M3 69 1411421 C T
CED83999 X.sub.2718 M3 69 1421240 C T
CED84004 X.sub.2719 M3 69 1430120 C T
CED84006 X.sub.2720 M3 69 1529637 C T
CED84038 X.sub.2721 M3 69 1590302 G A
CED84059 X.sub.2722 M3 69 1601173 C T
CED84062 X.sub.2723 M3 69 1652288 C T
CED84077 X.sub.2724 M3 69 1674261 C T
CED84084 X.sub.2725 M3 69 1688555 C T
CED84088 X.sub.2726 M3 69 1694047 C T
CED84089 X.sub.2727 M3 69 1714728 G A
CED84097 X.sub.2728 M3 69 1735172 G A
CED84108 X.sub.2729 M3 69 1784836 C T
CED84123 X.sub.2730 M3 69 1790823 C T
CED84125 X.sub.2731 M3 69 1792597 C T
CED84126 X.sub.2732 M3 69 1799816 C T
CED84128 X.sub.2733 M3 69 1800584 G A
CED84129 X.sub.2734 M3 69 1842064 C T
CED84140 X.sub.2735 M3 69 1854739 G A
CED84145 X.sub.2736 M3 69 1905120 C T
CED84166 X.sub.2737 M3 69 1924621 C T
CED84172 X.sub.2738 M3 69 1957485 C T
CED84187 X.sub.2739 M3 69 1967529 C T
CED84189 X.sub.2740 M3 69 1968848 A G
CED84189 X.sub.2741 M3 69 2001469 C T
CED84197 X.sub.2742 M3 69 2071540 C T
CED84226 X.sub.2743 M3 69 2156050 C T
CED84252 X.sub.2744 M3 69 2160207 C T
CED84255 X.sub.2745 M3 69 2165708 G A
CED84257 X.sub.2746 M3 69 2235113 C T
CED84274 X.sub.2747 M3 69 2260222 C T
CED84282 X.sub.2748 M3 69 2275703 G A
CED84290 X.sub.2749 M3 69 2421550 C T
CED84338 X.sub.2750 M3 69 2438727 C T
CED84343 X.sub.2751 M3 69 2483433 G A
CED84352 X.sub.2752 M3 72 93 T C
X.sub.2753 M3 72 584 G A
X.sub.2754 M3 72 856 C T
X.sub.2755 M3 72 1163 C T
X.sub.2756 M3 73 928 C T
CDZ96628 X.sub.2757 M3 75 451 C A
CDZ96630 X.sub.2758 M3 75 461 T C
CDZ96630 X.sub.2759 M3 77 7804 T A
CDZ96631 X.sub.2760 M3 77 18912 A G
CDZ96635 X.sub.2761 M3 77 34275 A G
CDZ96644 X.sub.2762 M3 77 34978 G T
CDZ96642 X.sub.2763 M3 77 37340 A G
CDZ96645 X.sub.2764 M3 77 39842 G A
CDZ96646 X.sub.2765 M3 77 65419 G A
CDZ96655 X.sub.2766 M3 77 84022 G A
CDZ96659 X.sub.2767 M3 78 1865 C T
CED84359 X.sub.2768 M3 78 6333 G A
CED84360 X.sub.2769 M3 78 26915 C T
CED84366 X.sub.2770 M3 78 89958 C T
CED84387 X.sub.2771 M3 78 158534 G A
CED84406 X.sub.2772 M3 78 203274 G A
CED84420 X.sub.2773 M3 78 238854 C T
CED84430 X.sub.2774 M3 78 262639 C T
CED84438 X.sub.2775 M3 78 262683 G A
CED84438 X.sub.2776 M3 78 263828 T C
CED84438 X.sub.2777 M3 78 263896 T C
CED84438 X.sub.2778 M3 78 281454 C A
CED84441 X.sub.2779 M3 78 292139 A T
CED84442 X.sub.2780 M3 78 298141 C G
CED84443 X.sub.2781 M3 78 299166 G A
CED84443 X.sub.2782 M3 78 299644 G A
CED84443 X.sub.2783 M3 78 333312 A G
CED84452 X.sub.2784 M3 78 386356 C T
CED84472 X.sub.2785 M3 78 415432 G A
CED84479 X.sub.2786 M3 78 439640 C T
CED84487 X.sub.2787 M3 78 440606 C T
CED84487 X.sub.2788 M3 78 506703 G A
CED84508 X.sub.2789 M3 78 587686 G A
CED84539 X.sub.2790 M3 78 715700 G A
CED84582 X.sub.2791 M3 78 718885 C T
CED84584 X.sub.2792 M3 78 720093 G A
CED84583 X.sub.2793 M3 78 763771 G A
CED84600 X.sub.2794 M3 78 774252 G A
CED84602 X.sub.2795 M3 78 875825 C T
CED84633 X.sub.2796 M3 78 918865 C T
CED84651 X.sub.2797 M3 78 939705 G A
CED84658 X.sub.2798 M3 78 952815 G A
CED84662 X.sub.2799 M3 78 952860 G A
CED84662 X.sub.2800 M3 78 976680 C T
CED84672 X.sub.2801 M3 78 976799 C T
CED84672 X.sub.2802 M3 78 1023381 G A
CED84688 X.sub.2803 M3 78 1067609 G A
CED84705 X.sub.2804 M3 78 1086537 C T
CED84713 X.sub.2805 M3 78 1108918 C T
CED84721 X.sub.2806 M3 78 1111002 G A
CED84721 X.sub.2807 M3 78 1115511 G A
CED84723 X.sub.2808 M3 78 1155093 C T
CED84732 X.sub.2809 M3 78 1213556 G A
CED84752 X.sub.2810 M3 78 1216573 C T
CED84752 X.sub.2811 M3 78 1247678 C T
CED84761 X.sub.2812 M3 78 1278982 C T
CED84773 X.sub.2813 M3 78 1300968 C T
CED84783 X.sub.2814 M3 78 1302286 C T
CED84782 X.sub.2815 M3 78 1315648 C T
CED84788 X.sub.2816 M3 78 1317124 G A
CED84787 X.sub.2817 M3 78 1344640 C T
CED84795 X.sub.2818 M3 78 1356873 C T
CED84800 X.sub.2819 M3 78 1376517 G A
CED84810 X.sub.2820 M3 78 1397982 G A
CED84818 X.sub.2821 M3 78 1406981 C T
CED84821 X.sub.2822 M3 78 1426722 C T
CED84829 X.sub.2823 M3 78 1475803 G A
CED84845 X.sub.2824 M3 78 1493542 C T
CED84851 X.sub.2825 M3 78 1568326 C T
CED84868 X.sub.2826 M3 78 1627007 G A
CED84885 X.sub.2827 M3 78 1642170 G A
CED84889 X.sub.2828 M3 78 1660408 G A
CED84897 X.sub.2829 M3 78 1674126 G A
CED84904 X.sub.2830 M3 78 1694684 C T
CED84912 X.sub.2831 M3 78 1721661 G A
CED84921 X.sub.2832 M3 78 1742796 G A
CED84926 X.sub.2833 M3 79 65 G A
CDZ96674 X.sub.2834 M3 79 133 A G
CDZ96674 X.sub.2835 M3 79 161 T C
CDZ96674 X.sub.2836 M3 79 36113 C T
CDZ96682 X.sub.2837 M3 79 57804 G A
CDZ96687 X.sub.2838 M3 79 64658 C T
CDZ96688 X.sub.2839 M3 79 71637 C T
CDZ96691 X.sub.2840 M3 79 132683 C T
CDZ96713 X.sub.2841 M3 79 168570 C T
CDZ96727 X.sub.2842 M3 79 255486 C T
CDZ96758 X.sub.2843 M3 79 307021 C T
CDZ96777 X.sub.2844 M3 79 324145 C T
CDZ96781 X.sub.2845 M3 79 345646 G A
CDZ96789 X.sub.2846 M3 79 346823 G A
CDZ96789 X.sub.2847 M3 79 394300 C T
CDZ96804 X.sub.2848 M3 79 409085 C T
CDZ96810 X.sub.2849 M3 79 492523 C T
CDZ96842 X.sub.2850 M3 79 509666 C T
CDZ96848 X.sub.2851 M3 79 575411 C T
CDZ96868 X.sub.2852 M3 79 579674 G A
CDZ96871 X.sub.2853 M3 79 604739 G A
CDZ96879 X.sub.2854 M3 79 617057 C T
CDZ96882 X.sub.2855 M3 79 679140 C T
CDZ96904 X.sub.2856 M3 79 686946 C T
CDZ96907 X.sub.2857 M3 79 696174 G A
CDZ96911 X.sub.2858 M3 79 735053 T C
CDZ96928 X.sub.2859 M3 79 747717 A G
CDZ96929 X.sub.2860 M3 79 748083 G T
CDZ96929 X.sub.2861 M3 79 758025 G A
CDZ96931 X.sub.2862 M3 79 758078 T C
CDZ96931 X.sub.2863 M3 79 759195 T A
CDZ96931 X.sub.2864 M3 79 759403 C T
CDZ96931 X.sub.2865 M3 79 759659 G A
CDZ96931 X.sub.2866 M3 79 760430 T C
CDZ96932 X.sub.2867 M3 79 760458 G T
CDZ96932 X.sub.2868 M3 79 760541 A G
CDZ96932 X.sub.2869 M3 79 760891 A G
CDZ96932 X.sub.2870 M3 79 760904 T C
CDZ96932 X.sub.2871 M3 79 761056 T C
CDZ96932 X.sub.2872 M3 79 768537 A G
CDZ96933 X.sub.2873 M3 79 771663 T G
CDZ96933 X.sub.2874 M3 79 786064 A G
CDZ96934 X.sub.2875 M3 79 798799 C T
CDZ96939 X.sub.2876 M3 79 864204 C T
CDZ96959 X.sub.2877 M3 79 874161 G A
CDZ96965 X.sub.2878 M3 79 933234 G A
CDZ96987 X.sub.2879 M3 79 940003 C T
CDZ96991 X.sub.2880 M3 79 1000786 A G
CDZ97007 X.sub.2881 M3 79 1044652 G A
CDZ97023 X.sub.2882 M3 79 1069426 C T
CDZ97032 X.sub.2883 M3 79 1082233 G A
CDZ97037 X.sub.2884 M3 79 1118598 C T
CDZ97048 X.sub.2885 M3 79 1123288 C T
CDZ97049 X.sub.2886 M3 79 1140763 G A
CDZ97053 X.sub.2887 M3 79 1149291 G A
CDZ97056 X.sub.2888 M3 79 1211985 G A
CDZ97077 X.sub.2889 M3 79 1229129 G A
CDZ97086 X.sub.2890 M3 79 1231740 C T
CDZ97087 X.sub.2891 M3 79 1265502 C T
CDZ97100 X.sub.2892 M3 79 1279548 G A
CDZ97105 X.sub.2893 M3 79 1318034 C T
CDZ97117 X.sub.2894 M3 79 1336766 C T
CDZ97121 X.sub.2895 M3 79 1371491 C T
CDZ97129 X.sub.2896 M3 79 1394034 G A
CDZ97137 X.sub.2897 M3 79 1410287 C T
CDZ97145 X.sub.2898 M3 79 1410481 G A
CDZ97145 X.sub.2899 M3 79 1430954 G A
CDZ97152 X.sub.2900 M3 79 1540205 C T
CDZ97186 X.sub.2901 M3 79 1556423 C T
CDZ97191 X.sub.2902 M3 79 1624415 G A
CDZ97217 X.sub.2903 M3 79 1651212 C T
CDZ97224 X.sub.2904 M3 79 1674448 G A
CDZ97228 X.sub.2905 M3 79 1788096 G A
CDZ97262 X.sub.2906 M3 79 1791482 G A
CDZ97263 X.sub.2907 M3 79 1797660 C T
CDZ97265 X.sub.2908 M3 79 1797676 G A
CDZ97265 X.sub.2909 M3 79 1809211 C T
CDZ97268 X.sub.2910 M3 79 1842448 G A
CDZ97282 X.sub.2911 M3 79 1842834 G A
CDZ97282 X.sub.2912 M3 79 1850295 G A
CDZ97285 X.sub.2913 M3 79 1855037 A G
CDZ97285 X.sub.2914 M3 79 1859220 A G
CDZ97291 X.sub.2915 M3 79 1877329 G A
CDZ97295 X.sub.2916 M3 79 1930688 G A
CDZ97315 X.sub.2917 M3 79 1990424 G A
CDZ97334 X.sub.2918 M3 79 2013361 C T
CDZ97344 X.sub.2919 M3 79 2066016 C T
CDZ97366 X.sub.2920 M3 79 2115870 G A
CDZ97380 X.sub.2921 M3 79 2121041 G A
CDZ97380 X.sub.2922 M3 79 2152573 C T
CDZ97392 X.sub.2923 M3 79 2172085 C T
CDZ97397 X.sub.2924 M3 79 2179936 G A
CDZ97402 X.sub.2925 M3 79 2188410 G A
CDZ97405 X.sub.2926 M3 79 2268540 C T
CDZ97435 X.sub.2927 M3 79 2315869 A C
CDZ97452 X.sub.2928 M3 79 2323713 C T
CDZ97455 X.sub.2929 M3 79 2339881 C G
CDZ97460 X.sub.2930 M3 79 2340326 G A
CDZ97462 X.sub.2931 M3 85 421 G A
X.sub.2932 M3 85 425 C T
X.sub.2933 M3 85 462 G A
X.sub.2934 M3 85 463 A G
X.sub.2935 M3 85 467 A T
X.sub.2936 M3 85 512 A G
X.sub.2937 M3 85 516 G A
X.sub.2938 M3 85 521 C T
X.sub.2939 M3 85 522 A G
X.sub.2940 M3 86 230 A G
X.sub.2941 M3 88 119 C T
CDZ97464 X.sub.2942 M3 88 196 G A
CDZ97464 X.sub.2943 M3 88 898 C T
CDZ97464 X.sub.2944 M3 99 245 G A
X.sub.2945 M3 103 768 C T
X.sub.2946 M3 106 278 A G
X.sub.2947 M3 109 396 T C
X.sub.2948 M3 118 396 C T
CDZ97478 X.sub.2949 M3 118 870 G A
CDZ97478 X.sub.2950 M3 118 1491 G A
CDZ97478 X.sub.2951 M3 121 907 T C
X.sub.2952 M3 121 1402 C G
X.sub.2953 M3 124 69730 G A
CDZ97501 X.sub.2954 M3 124 72117 G A
CDZ97501 X.sub.2955 M3 124 72760 G A
CDZ97501 X.sub.2956 M3 124 80266 C T
CDZ97504 X.sub.2957 M3 124 94611 G A
CDZ97507 X.sub.2958 M3 124 156052 G A
CDZ97524 X.sub.2959 M3 124 194455 C T
CDZ97538 X.sub.2960 M3 124 222249 C T
CDZ97547 X.sub.2961 M3 125 35864 T C
CDZ97573 X.sub.2962 M3 129 299 G A
CDZ97577 X.sub.2963 M3 129 433 G A
CDZ97577 X.sub.2964 M3 129 856 G A
CDZ97577 X.sub.2965 M3 129 1013 C T
CDZ97577 X.sub.2966 M3 130 674 C T
CDZ97578 X.sub.2967 M3 141 5649 C T
CDZ97582 X.sub.2968 M3 141 10162 G A
CDZ97582 X.sub.2969 M3 141 15764 C T
CDZ97587 X.sub.2970 M3 141 17894 G A
CDZ97587 X.sub.2971 M3 141 29260 G A
CDZ97594 X.sub.2972 M3 149 2074 T G
CDZ97598 X.sub.2973 M3 149 2453 C T
CDZ97598 X.sub.2974 M3 159 106 A C
X.sub.2975 M3 162 70025 C T
CDZ97625 X.sub.2976 M3 162 70405 A G
CDZ97625 X.sub.2977 M3 162 93443 G A
CDZ97631 X.sub.2978 M3 162 96194 G A
CDZ97631 X.sub.2979 M3 162 223407 C T
CDZ97674 X.sub.2980 M3 162 227242 G A
CDZ97674 X.sub.2981 M3 162 230526 C T
CDZ97676 X.sub.2982 M3 162 291566 G A
CDZ97695 X.sub.2983 M3 162 308369 T C
CDZ97702 X.sub.2984 M3 162 321070 C T
CDZ97703 X.sub.2985 M3 162 321073 A G
CDZ97703 X.sub.2986 M3 162 321460 C G
CDZ97703 X.sub.2987 M3 162 321463 A C
CDZ97703 X.sub.2988 M3 162 322591 G A
CDZ97703 X.sub.2989 M3 162 323448 T G
CDZ97703 X.sub.2990 M3 162 323451 T G
CDZ97703 X.sub.2991 M3 162 323480 T C
CDZ97703 X.sub.2992 M3 162 323735 A G
CDZ97703 X.sub.2993 M3 162 324114 T C
CDZ97703 X.sub.2994 M3 162 324139 C T
CDZ97703 X.sub.2995 M3 162 324568 A G
CDZ97703 X.sub.2996 M3 162 341717 G A
CDZ97707 X.sub.2997 M3 162 351016 C T
CDZ97711 X.sub.2998 M3 162 360320 G A
CDZ97714 X.sub.2999 M3 162 423180 C T
CDZ97740 X.sub.3000 M3 162 424391 C T
CDZ97740 X.sub.3001 M3 162 444123 T C
CDZ97748 X.sub.3002 M3 162 456498 C T
CDZ97752 X.sub.3003 M3 162 467207 C T
CDZ97755 X.sub.3004 M3 162 476928 C T
CDZ97760 X.sub.3005 M3 162 491906 G A
CDZ97764 X.sub.3006 M3 162 492078 G A
CDZ97764 X.sub.3007 M3 162 492101 G A
CDZ97764 X.sub.3008 M3 162 501886 C T
CDZ97769 X.sub.3009 M3 162 632311 G A
CDZ97814 X.sub.3010 M3 162 633321 G A
CDZ97814 X.sub.3011 M3 162 633633 G A
CDZ97814 X.sub.3012 M3 162 640005 C T
CDZ97815 X.sub.3013 M3 162 645194 G A
CDZ97815 X.sub.3014 M3 162 674192 C T
CDZ97824 X.sub.3015 M3 162 738675 G A
CDZ97842 X.sub.3016 M3 162 738686 C T
CDZ97842 X.sub.3017 M3 162 792386 G A
CDZ97863 X.sub.3018 M3 162 801198 C T
CDZ97864 X.sub.3019 M3 162 808830 G A
CDZ97869 X.sub.3020 M3 162 848369 G A
CDZ97884 X.sub.3021 M3 162 871911 C T
CDZ97890 X.sub.3022 M3 162 885927 C T
CDZ97896 X.sub.3023 M3 162 966019 C T
CDZ97923 X.sub.3024 M3 162 972973 G A
CDZ97925 X.sub.3025 M3 175 385 A C
X.sub.3026 M3 189 32 G A
CDZ97960 X.sub.3027 M3 189 108326 C T
CDZ97991 X.sub.3028 M3 189 126573 G A
CDZ97996 X.sub.3029 M3 189 127854 C T
CDZ97998 X.sub.3030 M3 189 174918 G A
CDZ98015 X.sub.3031 M3 189 194647 A G
CDZ98020 X.sub.3032 M3 189 194665 A G
CDZ98020 X.sub.3033 M3 189 298487 C T
CDZ98056 X.sub.3034 M3 189 323680 C T
CDZ98063 X.sub.3035 M3 189 371247 G A
CDZ98078 X.sub.3036 M3 189 394551 C T
CDZ98085 X.sub.3037 M3 189 452298 G A
CDZ98106 X.sub.3038 M3 191 342 A G
CDZ98107 X.sub.3039 M3 191 347 C T
CDZ98107 X.sub.3040 M3 191 427 C T
CDZ98107 X.sub.3041 M3 191 451 C T
CDZ98107 X.sub.3042 M3 191 487 A G
CDZ98107 X.sub.3043 M3 197 624 C T
CDZ98111 X.sub.3044 M3 198 202 C A
X.sub.3045 M3 198 203 G A
X.sub.3046 M3 198 238 C T
X.sub.3047 M3 198 265 C T
X.sub.3048 M3 199 688 C T
X.sub.3049 M3 199 911 C T
X.sub.3050 M3 199 971 C T
X.sub.3051 M3 199 1218 C T
X.sub.3052 M3 202 171 C T
X.sub.3053 M3 205 360 C T
CDZ98112 X.sub.3054 M3 205 981 C T
CDZ98112 X.sub.3055 M3 208 117 G A
X.sub.3056 M3 208 476 G A
X.sub.3057 M3 208 616 G A
X.sub.3058 M3 208 935 G A
X.sub.3059 M3 209 312 C T
CDZ98113 X.sub.3060 M3 223 93 G A
CDZ98118 X.sub.3061 M3 223 102 A G
CDZ98118 X.sub.3062 M3 223 133 A G
CDZ98118 X.sub.3063 M3 223 150 T C
CDZ98118 X.sub.3064 M3 223 155 A C
CDZ98118 X.sub.3065 M3 223 158 T C
CDZ98118 X.sub.3066 M3 223 160 C T
CDZ98118 X.sub.3067 M3 223 175 G A
CDZ98118 X.sub.3068 M3 223 177 A G
CDZ98118 X.sub.3069 M3 223 188 A G
CDZ98118 X.sub.3070 M3 223 192 C A
CDZ98118 X.sub.3071 M3 223 194 T C
CDZ98118 X.sub.3072 M3 223 195 T G
CDZ98118 X.sub.3073 M3 223 197 T C
CDZ98118 X.sub.3074 M3 223 202 G C
CDZ98118 X.sub.3075 M3 223 205 C T
CDZ98118 X.sub.3076 M3 223 291 C A
CDZ98118 X.sub.3077 M3 223 360 C T
CDZ98118 X.sub.3078 M3 225 317 C T
X.sub.3079 M3 227 202 G A
X.sub.3080 M3 229 225 G C
X.sub.3081 M3 232 340 G A
CDZ98119 X.sub.3082 M3 232 1379 C T
CDZ98119 X.sub.3083 M3 232 1521 C T
CDZ98119 X.sub.3084 M3 232 1662 G A
CDZ98119 X.sub.3085 M3 232 1761 C T
CDZ98119 X.sub.3086 M3 232 2027 C T
CDZ98119 X.sub.3087 M3 232 3060 C T
CDZ98120 X.sub.3088 M3 232 3284 C T
CDZ98119 X.sub.3089 M3 232 4437 G A
CDZ98121 X.sub.3090 M3 232 4561 C T
CDZ98120 X.sub.3091 M3 242 7334 C T
CDZ98125 X.sub.3092 M3 242 41710 G A
CDZ98131 X.sub.3093 M3 242 50262 G A
CDZ98135 X.sub.3094 M3 242 107587 G A
CDZ98153 X.sub.3095 M3 242 125424 C T
CDZ98159 X.sub.3096 M3 242 150461 C T
CDZ98164 X.sub.3097 M3 242 168689 G A
CDZ98172 X.sub.3098 M3 242 189498 G A
CDZ98176 X.sub.3099 M3 242 194983 C T
CDZ98179 X.sub.3100 M3 242 213986 G A
CDZ98185 X.sub.3101 M3 242 219778 C T
CDZ98187 X.sub.3102 M3 242 220015 G A
CDZ98187 X.sub.3103 M3 242 227271 C T
CDZ98191 X.sub.3104 M3 242 233088 G A
CDZ98193 X.sub.3105 M3 242 233141 G A
CDZ98193 X.sub.3106 M3 242 310353 G A
CDZ98216 X.sub.3107 M3 242 342570 C T
CDZ98229 X.sub.3108 M3 242 363677 G A
CDZ98233 X.sub.3109 M3 242 376713 G A
CDZ98238 X.sub.3110 M3 242 404132 G A
CDZ98248 X.sub.3111 M3 242 412676 G A
CDZ98249 X.sub.3112 M3 242 437941 G A
CDZ98258 X.sub.3113 M3 242 472562 C T
CDZ98266 X.sub.3114 M3 242 485936 G A
CDZ98270 X.sub.3115 M3 242 492389 G A
CDZ98274 X.sub.3116 M3 242 514780 C T
CDZ98282 X.sub.3117 M3 242 542663 G A
CDZ98290 X.sub.3118 M3 242 559999 G A
CDZ98297 X.sub.3119 M3 242 570416 G A
CDZ98299 X.sub.3120 M3 242 577367 G A
CDZ98302 X.sub.3121 M3 242 602456 G A
CDZ98308 X.sub.3122 M3 242 602531 G A
CDZ98308 X.sub.3123 M3 242 604704 C T
CDZ98309 X.sub.3124 M3 242 641669 G A
CDZ98323 X.sub.3125 M3 242 649715 G A
CDZ98326 X.sub.3126 M3 246 329 C G
CDZ98328 X.sub.3127 M3 246 331 T C
CDZ98328 X.sub.3128 M3 249 2757 C T
CED84929 X.sub.3129 M3 249 2763 A T
CED84929 X.sub.3130 M3 249 5307 C T
CED84929 X.sub.3131 M3 249 72016 C T
CED84950 X.sub.3132 M3 249 123789 C T
CED84972 X.sub.3133 M3 249 157550 C T
CED84983 X.sub.3134 M3 249 191304 C T
CED84988 X.sub.3135 M3 249 253494 C T
CED85008 X.sub.3136 M3 249 272075 C T
CED85013 X.sub.3137 M3 249 289154 C T
CED85018 X.sub.3138 M3 249 294161 G A
CED85018 X.sub.3139 M3 249 294853 C T
CED85019 X.sub.3140 M3 249 305975 G A
CED85023 X.sub.3141 M3 249 326271 C T
CED85029 X.sub.3142 M3 249 342990 G A
CED85036 X.sub.3143 M3 249 445429 G A
CED85075 X.sub.3144 M3 249 469645 G A
CED85087 X.sub.3145 M3 249 476060 A G
CED85088 X.sub.3146 M3 249 485782 C T
CED85089 X.sub.3147 M3 249 487588 G A
CED85090 X.sub.3148 M3 249 500195 C T
CED85093 X.sub.3149 M3 249 501310 C T
CED85093 X.sub.3150 M3 249 501510 T C
CED85093 X.sub.3151 M3 249 532943 A G
CED85099 X.sub.3152 M3 249 565916 C T
CED85113 X.sub.3153 M3 249 571922 C T
CED85115 X.sub.3154 M3 249 576070 G A
CED85118 X.sub.3155 M3 249 598579 C T
CED85125 X.sub.3156 M3 249 634793 A G
CED85133 X.sub.3157 M3 249 637944 G A
CED85135 X.sub.3158 M3 249 660408 G A
CED85144 X.sub.3159 M3 249 854220 G A
CED85201 X.sub.3160 M3 249 889853 G A
CED85211 X.sub.3161 M3 249 911274 C T
CED85218 X.sub.3162 M3 249 932606 C T
CED85223 X.sub.3163 M3 249 934305 G A
CED85225 X.sub.3164 M3 249 935435 C T
CED85225 X.sub.3165 M3 249 945434 C T
CED85227 X.sub.3166 M3 249 945727 C T
CED85227 X.sub.3167 M3 249 969333 G T
CED85238 X.sub.3168 M3 249 972975 G A
CED85240 X.sub.3169 M3 249 977170 C T
CED85242 X.sub.3170 M3 249 989520 C T
CED85243 X.sub.3171 M3 249 1014098 C T
CED85252 X.sub.3172 M3 249 1088841 T C
CED85274 X.sub.3173 M3 249 1116964 G A
CED85283 X.sub.3174 M3 249 1144309 G A
CED85291 X.sub.3175 M3 249 1155955 C T
CED85297 X.sub.3176 M3 249 1176977 G A
CED85303 X.sub.3177 M3 249 1195367 G A
CED85307 X.sub.3178 M3 249 1209489 C T
CED85313 X.sub.3179 M3 249 1230068 C T
CED85319 X.sub.3180 M3 249 1286733 G A
CED85336 X.sub.3181 M3 249 1299472 C T
CED85343 X.sub.3182 M3 249 1310059 C T
CED85346 X.sub.3183 M3 249 1473930 C T
CED85404 X.sub.3184 M3 249 1473937 G A
CED85404 X.sub.3185 M3 249 1486325 G A
CED85409 X.sub.3186 M3 249 1498029 T C
CED85415 X.sub.3187 M3 249 1498884 T C
CED85414 X.sub.3188 M3 249 1499008 A G
CED85415 X.sub.3189 M3 249 1502631 G T
CED85416 X.sub.3190 M3 249 1502641 T A
CED85416 X.sub.3191 M3 249 1502819 T G
CED85416 X.sub.3192 M3 249 1505138 G A
CED85416 X.sub.3193 M3 249 1505634 T G
CED85416 X.sub.3194 M3 249 1519431 A G
CED85419 X.sub.3195 M3 249 1523260 C T
CED85419 X.sub.3196 M3 249 1599907 C T
CED85444 X.sub.3197 M3 249 1619036 G A
CED85450 X.sub.3198 M3 249 1623151 G A
CED85451 X.sub.3199 M3 249 1653615 T G
CED85457 X.sub.3200 M3 249 1653962 C T
CED85458 X.sub.3201 M3 249 1666185 C T
CED85460 X.sub.3202 M3 249 1726777 C T
CED85474 X.sub.3203 M3 249 1760715 C T
CED85489 X.sub.3204 M3 249 1769706 A G
CED85490 X.sub.3205 M3 249 1780551 A G
CED85493 X.sub.3206 M3 249 1780569 A G
CED85493 X.sub.3207 M3 249 1801965 G A
CED85501 X.sub.3208 M3 249 1803575 C T
CED85502 X.sub.3209 M3 249 1804835 G A
CED85502 X.sub.3210 M3 249 1880762 G A
CED85525 X.sub.3211 M3 249 1944026 G A
CED85545 X.sub.3212 M3 249 1981230 G A
CED85557 X.sub.3213 M3 249 1988505 C T
CED85560 X.sub.3214 M3 249 2015272 G A
CED85567 X.sub.3215 M3 249 2027477 G A
CED85573 X.sub.3216 M3 249 2047401 C T
CED85581 X.sub.3217 M3 249 2110956 C T
CED85603 X.sub.3218 M3 249 2163304 G A
CED85618 X.sub.3219 M3 249 2167664 G A
CED85620 X.sub.3220 M3 249 2178506 G A
CED85622 X.sub.3221 M3 249 2183695 G A
CED85623 X.sub.3222 M3 249 2198205 G A
CED85628 X.sub.3223 M3 249 2223626 G A
CED85633 X.sub.3224 M3 249 2255547 G C
CED85640 X.sub.3225 M3 25 1089 T C
X.sub.3226 M3 252 512 C T
X.sub.3227 M3 252 524 C T
X.sub.3228 M3 258 836 A G
X.sub.3229 M3 258 1139 A T
X.sub.3230 M3 260 156 G A
X.sub.3231 M3 262 4049 G A
CDZ98330 X.sub.3232 M3 262 12289 C T
CDZ98333 X.sub.3233 M3 262 30347 G A
CDZ98338 X.sub.3234 M3 262 30359 G A
CDZ98338 X.sub.3235 M3 262 81226 G A
CDZ98358 X.sub.3236 M3 262 108865 C T
CDZ98369 X.sub.3237 M3 262 143387 C T
CDZ98375 X.sub.3238 M3 262 148151 C T
CDZ98375 X.sub.3239 M3 262 153091 G A
CDZ98377 X.sub.3240 M3 262 164438 G A
CDZ98383 X.sub.3241 M3 262 201531 G A
CDZ98396 X.sub.3242 M3 262 221937 C T
CDZ98403 X.sub.3243 M3 262 309128 C T
CDZ98434 X.sub.3244 M3 262 319302 G A
CDZ98436 X.sub.3245 M3 262 351354 G A
CDZ98450 X.sub.3246 M3 262 380519 C T
CDZ98457 X.sub.3247 M3 262 383215 C T
CDZ98459 X.sub.3248 M3 262 397539 G A
CDZ98463 X.sub.3249 M3 262 414403 C T
CDZ98467 X.sub.3250 M3 262 420102 G A
CDZ98468 X.sub.3251 M3 262 444331 G A
CDZ98477 X.sub.3252 M3 262 446956 C T
CDZ98477 X.sub.2253 M3 262 451669 C T
CDZ98478 X.sub.3254 M3 262 531136 G A
CDZ98510 X.sub.3255 M3 262 539452 A G
CDZ98514 X.sub.3256 M3 262 557280 G A
CDZ98518 X.sub.3257 M3 262 560713 G A
CDZ98519 X.sub.3258 M3 262 562795 C T
CDZ98521 X.sub.3259 M3 262 567591 G A
CDZ98524 X.sub.3260 M3 262 567801 G A
CDZ98524 X.sub.3261 M3 262 573667 C T
CDZ98526 X.sub.3262 M3 262 607661 G A
CDZ98533 X.sub.3263 M3 262 618198 G A
CDZ98538 X.sub.3264 M3 262 627573 T C
CDZ98542 X.sub.3265 M3 262 638804 G C
CDZ98544 X.sub.3266 M3 262 638986 C G
CDZ98544 X.sub.3267 M3 262 639006 C T
CDZ98544 X.sub.3268 M3 262 639869 G C
CDZ98544 X.sub.3269 M3 262 639962 A G
CDZ98544 X.sub.3270 M3 262 640066 A G
CDZ98544 X.sub.3271 M3 262 653920 A G
CDZ98545 X.sub.3272 M3 262 655754 A T
CDZ98545 X.sub.3273 M3 262 655757 T C
CDZ98545 X.sub.3274 M3 262 656031 C A
CDZ98545 X.sub.3275 M3 262 656323 C G
CDZ98545 X.sub.3276 M3 262 668764 C T
CDZ98545 X.sub.3277 M3 262 691577 C T
CDZ98551 X.sub.3278 M3 262 714374 A C
CDZ98557 X.sub.3279 M3 262 714377 A G
CDZ98557 X.sub.3280 M3 262 771330 G A
CDZ98578 X.sub.3281 M3 262 801626 G A
CDZ98589 X.sub.3282 M3 262 822734 G A
CDZ98597 X.sub.3283 M3 262 835874 C T
CDZ98601 X.sub.3284 M3 262 865999 G A
CDZ98613 X.sub.3285 M3 262 971713 G A
CDZ98649 X.sub.3286 M3 262 1016286 C T
CDZ98661 X.sub.3287 M3 262 1044256 G A
CDZ98669 X.sub.3288 M3 262 1051389 C T
CDZ98670 X.sub.3289 M3 262 1060326 C T
CDZ98672 X.sub.3290 M3 262 1107286 C T
CDZ98689 X.sub.3291 M3 262 1140198 C T
CDZ98701 X.sub.3292 M3 262 1204782 G A
CDZ98722 X.sub.3293 M3 262 1209662 G A
CDZ98723 X.sub.3294 M3 262 1226072 C T
CDZ98730 X.sub.3295 M3 262 1233054 G A
CDZ98733 X.sub.3296 M3 262 1237021 C T
CDZ98735 X.sub.3297 M3 262 1277604 G A
CDZ98747 X.sub.3298 M3 262 1305361 G A
CDZ98753 X.sub.3299 M3 262 1329643 C T
CDZ98760 X.sub.3300 M3 262 1332176 C T
CDZ98761 X.sub.3301 M3 262 1349561 G A
CDZ98766 X.sub.3302 M3 262 1351116 A G
CDZ98766 X.sub.3303 M3 262 1415479 C T
CDZ98789 X.sub.3304 M3 262 1416604 C T
CDZ98788 X.sub.3305 M3 262 1424293 G A
CDZ98791 X.sub.3306 M3 262 1455677 G A
CDZ98804 X.sub.3307 M3 262 1458863 C T
CDZ98807 X.sub.3308 M3 262 1549966 C G
CDZ98834 X.sub.3309 M3 262 1550311 C T
CDZ98836 X.sub.3310 M3 262 1550456 C T
CDZ98837 X.sub.3311 M3 262 1558074 G A
CDZ98840 X.sub.3312 M3 262 1615762 G A
CDZ98855 X.sub.3313 M3 262 1694625 C T
CDZ98878 X.sub.3314 M3 262 1706076 G A
CDZ98885 X.sub.3315 M3 262 1709112 G A
CDZ98884 X.sub.3316 M3 262 1711527 G A
CDZ98886 X.sub.3317 M3 262 1716385 G A
CDZ98887 X.sub.3318 M3 262 1717611 C T
CDZ98888 X.sub.3319 M3 266 85 C T
X.sub.3320 M3 266 252 C T
X.sub.3321 M3 267 133 T C
X.sub.3322 M3 267 134 C T
X.sub.3323 M4 22 1643 C T
CED80056 X.sub.3324 M4 22 2524 G A
CED80056 X.sub.3325 M4 28 236 G A
CDZ96150 X.sub.3326 M4 28 377 G A
CDZ96150 X.sub.3327 M4 28 1506 C T
CDZ96150 X.sub.3328 M4 28 1677 C T
CDZ96150 X.sub.3329 M4 43 464 G A
CDZ96151 X.sub.3330 M4 43 753 C T
CDZ96151 X.sub.3331 M4 43 757 G A
CDZ96151 X.sub.3332 M4 43 1527 C T
CDZ96151 X.sub.3333 M4 43 1748 G A
CDZ96151 X.sub.3334 M4 43 1928 C T
CDZ96151 X.sub.3335 M4 62 26 T A
CDZ96152 X.sub.3336 M4 62 27 T C
CDZ96152 X.sub.3337 M4 62 55 T A
CDZ96152 X.sub.3338 M4 62 403 C T
CDZ96152 X.sub.3339 M4 62 875 G A
CDZ96152 X.sub.3340 M4 102 339 C T
CDZ96153 X.sub.3341 M4 102 951 G A
CDZ96153 X.sub.3342 M4 102 1042 G A
CDZ96153 X.sub.3343 M4 102 2334 G A
CDZ96153 X.sub.3344 M4 102 2590 C T
CDZ96153 X.sub.3345 M4 102 3427 C T
CDZ96153 X.sub.3346 M4 176 358 G A
CED80058 X.sub.3347 M4 176 1872 G A
CED80058 X.sub.3348 M4 176 1980 G A
CED80058 X.sub.3349 M4 176 2335 A G
CED80058 X.sub.3350 M4 176 2349 G A
CED80058 X.sub.3351 M4 179 1525 G A
CDZ96154 X.sub.3352 M4 179 1780 C T
CDZ96154 X.sub.3353 M4 188 815 C T
CED80060 X.sub.3354 M4 188 1174 C T
CED80060 X.sub.3355 M4 188 2163 G A
CED80060 X.sub.3356 M4 188 2170 G A
CED80060 X.sub.3357 M4 247 102 G A
CED80061 X.sub.3358 M4 247 989 C T
CED80061 X.sub.3359 M4 247 1053 G A
CED80061 X.sub.3360 M4 3 142 C T
X.sub.3361 M4 7 160 T C
X.sub.3362 M4 8 1110 C T
X.sub.3363 M4 11 154 A C
X.sub.3364 M4 11 158 C T
X.sub.3365 M4 15 28 C G
X.sub.3366 M4 24 513 T C
CDZ96160 X.sub.3367 M4 24 520 C G
CDZ96160 X.sub.3368 M4 24 5850 C T
CDZ96160 X.sub.3369 M4 24 180340 G A
CDZ96216 X.sub.3370 M4 24 216696 C T
CDZ96228 X.sub.3371 M4 24 266697 G A
CDZ96242 X.sub.3372 M4 24 307114 G A
CDZ96255 X.sub.3373 M4 24 340663 T C
CDZ96265 X.sub.3374 M4 24 420108 G A
CDZ96291 X.sub.3375 M4 24 422035 G A
CDZ96291 X.sub.3376 M4 24 470687 G A
CDZ96308 X.sub.3377 M4 27 445 C T
X.sub.3378 M4 27 1012 A C
X.sub.3379 M4 27 1013 T A
X.sub.3380 M4 32 158 C T
CDZ96332 X.sub.3381 M4 32 215 C T
CDZ96332 X.sub.3382 M4 32 2438 C T
CDZ96332 X.sub.3383 M4 32 2734 C T
CDZ96332 X.sub.3384 M4 32 2821 C T
CDZ96332 X.sub.3385 M4 32 3067 C T
CDZ96332 X.sub.3386 M4 32 3506 C T
CDZ96332 X.sub.3387 M4 32 3562 G A
CDZ96332 X.sub.3388 M4 33 399 T A
CED82002 X.sub.3389 M4 33 20227 G A
CED82006 X.sub.3390 M4 33 45488 C T
CED82012 X.sub.3391 M4 33 79913 G A
CED82024 X.sub.3392 M4 33 109397 G A
CED82038 X.sub.3393 M4 33 109494 G A
CED82038 X.sub.3394 M4 33 129733 G A
CED82045 X.sub.3395 M4 33 226363 G A
CED82075 X.sub.3396 M4 33 257786 C T
CED82084 X.sub.3397 M4 33 260027 G A
CED82084 X.sub.3398 M4 33 274627 G A
CED82091 X.sub.3399 M4 33 283808 C T
CED82093 X.sub.3400 M4 33 327840 C T
CED82108 X.sub.3401 M4 33 341890 G A
CED82113 X.sub.3402 M4 33 370630 A T
CED82121- CED82122 X.sub.3403 M4 33 372141 A C
CED82121- CED82122 X.sub.3404 M4 33 374131 A G
CED82121- CED82122 X.sub.3405 M4 33 374134 A G
CED82121- CED82122 X.sub.3406 M4 33 374137 A T
CED82121- CED82122 X.sub.3407 M4 33 374150 A C
CED82121- CED82122 X.sub.3408 M4 33 375339 A G
CED82121- CED82122 X.sub.3409 M4 33 375366 T C
CED82121- CED82122 X.sub.3410 M4 33 382577 C T
CED82122 X.sub.3411 M4 33 382832 G T
CED82122 X.sub.3412 M4 33 383212 G A
CED82122 X.sub.3413 M4 33 385319 A C
CED82122 X.sub.3414 M4 33 385527 C T
CED82122 X.sub.3415 M4 33 386225 G A
CED82124 X.sub.3416 M4 33 448815 G A
CED82144 X.sub.3417 M4 33 455451 C T
CED82146 X.sub.3418 M4 33 509127 C T
CED82166 X.sub.3419 M4 33 543070 C T
CED82179 X.sub.3420 M4 33 556726 C T
CED82183 X.sub.3421 M4 33 570390 G A
CED82188 X.sub.3422 M4 33 639242 G A
CED82208 X.sub.3423 M4 33 682740 C T
CED82220 X.sub.3424 M4 33 699423 C T
CED82227 X.sub.3425 M4 33 800536 G A
CED82259 X.sub.3426 M4 33 829825 C T
CED82271 X.sub.3427 M4 33 850373 G A
CED82278 X.sub.3428 M4 33 917771 A T
CED82294 X.sub.3429 M4 33 929585 T C
CED82297 X.sub.3430 M4 33 936571 A G
CED82300 X.sub.3431 M4 33 936600 G A
CED82300 X.sub.3432 M4 33 936667 A G
CED82300 X.sub.3433 M4 33 936697 A G
CED82300 X.sub.3434 M4 33 971503 C T
CED82307 X.sub.3435 M4 33 995886 G A
CED82318 X.sub.3436 M4 33 1005225 C T
CED82323 X.sub.3437 M4 33 1049699 G A
CED82334 X.sub.3438 M4 33 1053098 G C
CED82337 X.sub.3439 M4 33 1087773 G A
CED82349 X.sub.3440 M4 33 1138444 C T
CED82363 X.sub.3441 M4 33 1151553 C T
CED82367 X.sub.3442 M4 33 1165914 G A
CED82372 X.sub.3443 M4 33 1191727 C T
CED82379 X.sub.3444 M4 33 1291620 C T
CED82406 X.sub.3445 M4 33 1311181 G A
CED82413 X.sub.3446 M4 33 1316789 C T
CED82415 X.sub.3447 M4 33 1324395 G A
CED82417 X.sub.3448 M4 33 1339376 C T
CED82424 X.sub.3449 M4 33 1349009 C T
CED82427 X.sub.3450 M4 33 1411059 C T
CED82446 X.sub.3451 M4 33 1431038 G A
CED82451 X.sub.3452 M4 33 1470375 C T
CED82465 X.sub.3453 M4 33 1473759 G T
CED82464 X.sub.3454 M4 33 1499347 G A
CED82472 X.sub.3455 M4 33 1544767 A C
CED82485- CED82486 X.sub.3456 M4 33 1585699 C T
CED82497 X.sub.3457 M4 33 1587443 C T
CED82497 X.sub.3458 M4 33 1596242 C T
CED82498 X.sub.3459 M4 33 1638726 G A
CED82513 X.sub.3460 M4 33 1642659 G A
CED82515 X.sub.3461 M4 33 1652749 C T
CED82516 X.sub.3462 M4 33 1669434 G A
CED82524 X.sub.3463 M4 33 1700000 G A
CED82534 X.sub.3464 M4 33 1728730 G A
CED82541 X.sub.3465 M4 33 1740595 C T
CED82545 X.sub.3466 M4 33 1752414 G A
CED82547 X.sub.3467 M4 33 1823362 C T
CED82571 X.sub.3468 M4 33 1824401 C T
CED82572 X.sub.3469 M4 33 1860278 G A
CED82582 X.sub.3470 M4 33 1861675 C T
CED82583 X.sub.3471 M4 33 1862200 G A
CED82582 X.sub.3472 M4 33 1887401 C T
CED82591 X.sub.3473 M4 33 1889585 G A
CED82592 X.sub.3474 M4 33 1908405 G A
CED82599 X.sub.3475 M4 33 1938614 G A
CED82612 X.sub.3476 M4 33 1939670 C T
CED82612 X.sub.3477 M4 33 1967112 C T
CED82622 X.sub.3478 M4 33 2010230 C T
CED82636 X.sub.3479 M4 33 2050847 G A
CED82651 X.sub.3480 M4 36 320 G A
X.sub.3481 M4 36 1056 G A
X.sub.3482 M4 36 1295 C T
X.sub.3483 M4 36 1461 A T
X.sub.3484 M4 40 495 C G
X.sub.3485 M4 42 804 C T
CDZ96333 X.sub.3486 M4 42 1559 G A
CDZ96333 X.sub.3487 M4 48 563 C T
X.sub.3488 M4 48 565 T C
X.sub.3489 M4 48 576 G A
X.sub.3490 M4 48 580 T A
X.sub.3491 M4 50 145 G A
X.sub.3492 M4 52 6285 C T
CED82665 X.sub.3493 M4 52 136058 G A
CED82705 X.sub.3494 M4 52 144382 C T
CED82709 X.sub.3495 M4 52 145060 G A
CED82708 X.sub.3496 M4 52 151974 C T
CED82712 X.sub.3497 M4 52 183986 C T
CED82722 X.sub.3498 M4 52 203253 A G
CED82730 X.sub.3499 M4 52 207354 C T
CED82730 X.sub.3500 M4 52 223283 C G
CED82732- CED82733 X.sub.3501 M4 52 239773 C T
CED82734 X.sub.3502 M4 52 243203 G A
CED82733 X.sub.3503 M4 52 244305 G A
CED82734 X.sub.3504 M4 52 284733 G A
CED82747 X.sub.3505 M4 52 390095 G A
CED82784 X.sub.3506 M4 52 390988 C T
CED82785 X.sub.3507 M4 52 395374 G A
CED82786 X.sub.3508 M4 52 398723 C T
CED82786 X.sub.3509 M4 52 398728 C T
CED82786 X.sub.3510 M4 52 487472 C T
CED82814 X.sub.3511 M4 52 516267 C T
CED82823 X.sub.3512 M4 52 552099 G A
CED82837 X.sub.3513 M4 52 552173 G A
CED82837 X.sub.3514 M4 52 571124 G A
CED82845 X.sub.3515 M4 52 627827 C T
CED82860 X.sub.3516 M4 52 638622 G A
CED82862 X.sub.3517 M4 52 679670 G A
CED82877 X.sub.3518 M4 52 730557 G T
CED82899 X.sub.3519 M4 52 750413 G A
CED82908 X.sub.3520 M4 52 817452 T A
CED82928 X.sub.3521 M4 52 840755 C T
CED82935 X.sub.3522 M4 52 842352 C T
CED82934 X.sub.3523 M4 52 848043 A G
CED82937 X.sub.3524 M4 52 849671 G A
CED82940 X.sub.3525 M4 52 861376 C T
CED82946 X.sub.3526 M4 52 911438 G A
CED82964 X.sub.3527 M4 52 928854 C T
CED82971 X.sub.3528 M4 52 938650 G A
CED82973 X.sub.3529 M4 52 967316 A T
CED82984 X.sub.3530 M4 52 967701 T A
CED82983 X.sub.3531 M4 52 977048 G A
CED82990 X.sub.3532 M4 52 1003899 G A
CED83001 X.sub.3533 M4 52 1004724 G A
CED83001 X.sub.3534 M4 52 1029498 G A
CED83007 X.sub.3535 M4 52 1043011 C T
CED83012 X.sub.3536 M4 52 1049304 C T
CED83013 X.sub.3537 M4 52 1067895 C T
CED83020 X.sub.3538 M4 52 1157819 T A
CED83049 X.sub.3539 M4 52 1158103 C T
CED83051 X.sub.3540 M4 52 1214927 C T
CED83068 X.sub.3541 M4 52 1219894 C T
CED83071 X.sub.3542 M4 52 1227910 G A
CED83074 X.sub.3543 M4 52 1297876 G A
CED83099 X.sub.3544 M4 52 1336560 G A
CED83113 X.sub.3545 M4 52 1356590 C T
CED83120 X.sub.3546 M4 52 1363357 G A
CED83122 X.sub.3547 M4 52 1363405 C T
CED83123 X.sub.3548 M4 52 1373998 C T
CED83125 X.sub.3549 M4 52 1379155 G A
CED83128 X.sub.3550 M4 52 1381652 C T
CED83129 X.sub.3551 M4 52 1399439 G A
CED83134 X.sub.3552 M4 52 1409725 G A
CED83139 X.sub.3553 M4 52 1474412 G A
CED83166 X.sub.3554 M4 52 1509004 G A
CED83177 X.sub.3555 M4 52 1526796 G A
CED83181 X.sub.3556 M4 52 1540879 C T
CED83186 X.sub.3557 M4 52 1546812 G A
CED83188 X.sub.3558 M4 52 1570053 C T
CED83200 X.sub.3559 M4 52 1583655 C T
CED83206 X.sub.3560 M4 52 1590982 C T
CED83207 X.sub.3561 M4 52 1708900 A G
CED83249 X.sub.3562 M4 52 1715136 C T
CED83250 X.sub.3563 M4 52 1716210 C T
CED83250 X.sub.3564 M4 52 1750963 C T
CED83263 X.sub.3565 M4 52 1760440 G A
CED83266 X.sub.3566 M4 52 1765533 G A
CED83268 X.sub.3567 M4 52 1787135 C T
CED83275 X.sub.3568 M4 52 1788070 G A
CED83273 X.sub.3569 M4 52 1789922 G A
CED83276 X.sub.3570 M4 52 1793370 G A
CED83275 X.sub.3571 M4 52 1807309 G A
CED83283 X.sub.3572 M4 52 1809897 G A
CED83285 X.sub.3573 M4 52 1871310 C T
CED83304 X.sub.3574 M4 52 1874150 G T
CED83305 X.sub.3575 M4 52 1893352 G A
CED83313 X.sub.3576 M4 52 1938393 C T
CED83322 X.sub.3577 M4 52 1963875 G A
CED83335 X.sub.3578 M4 52 1987096 G A
CED83341 X.sub.3579 M4 52 1995167 G A
CED83342 X.sub.3580 M4 52 2041781 C T
CED83355 X.sub.3581 M4 52 2050245 G A
CED83359 X.sub.3582 M4 52 2081390 G A
CED83367 X.sub.3583 M4 52 2093251 C T
CED83368 X.sub.3584 M4 52 2120665 C T
CED83376 X.sub.3585 M4 52 2136885 A G
CED83382 X.sub.3586 M4 52 2162878 G A
CED83392 X.sub.3587 M4 52 2192445 G A
CED83400 X.sub.3588 M4 52 2211680 G A
CED83407 X.sub.3589 M4 52 2222126 C T
CED83410 X.sub.3590 M4 52 2229000 G A
CED83410 X.sub.3591 M4 52 2265219 C T
CED83425 X.sub.3592 M4 52 2266378 C T
CED83423 X.sub.3593 M4 52 2279651 G A
CED83430 X.sub.3591 M4 52 2308421 T C
CED83439 X.sub.3595 M4 52 2327266 C T
CED83445 X.sub.3596 M4 52 2364315 G A
CED83455 X.sub.3597 M4 52 2374740 C T
CED83456 X.sub.3598 M4 52 2400778 C T
CED83463 X.sub.3599 M4 52 2443575 G A
CED83476 X.sub.3600 M4 52 2531584 C T
CED83507 X.sub.3601 M4 52 2575090 A G
CED83525 X.sub.3602 M4 53 26291 G A
CDZ96348 X.sub.3603 M4 53 55702 C T
CDZ96359 X.sub.3604 M4 53 69664 C T
CDZ96363 X.sub.3605 M4 54 4150 A G
CDZ96383 X.sub.3606 M4 54 4815 G A
CDZ96384 X.sub.3607 M4 54 4816 A T
CDZ96384 X.sub.3608 M4 54 4817 G C
CDZ96384 X.sub.3609 M4 54 4821 G A
CDZ96384 X.sub.3610 M4 54 16963 C T
CDZ96386 X.sub.3611 M4 54 60769 G A
CDZ96403 X.sub.3612 M4 54 87716 G A
CDZ96410 X.sub.3613 M4 54 106086 G A
CDZ96416 X.sub.3614 M4 54 114442 G A
CDZ96419 X.sub.3615 M4 54 136832 C T
CDZ96425 X.sub.3616 M4 54 194230 G A
CDZ96446 X.sub.3617 M4 54 195804 G A
CDZ96447 X.sub.3618 M4 54 202467 C T
CDZ96448 X.sub.3619 M4 54 206494 G A
CDZ96450 X.sub.3620 M4 54 274617 A T
CDZ96471 X.sub.3621 M4 54 278479 C T
CDZ96474 X.sub.3622 M4 54 285008 C T
CDZ96475 X.sub.3623 M4 54 370320 G A
CDZ96499 X.sub.3624 M4 54 383172 C T
CDZ96506 X.sub.3625 M4 54 391223 A G
CDZ96509 X.sub.3626 M4 54 427542 C T
CDZ96520 X.sub.3627 M4 54 478527 C T
CDZ96537 X.sub.3628 M4 54 537282 T C
CDZ96557 X.sub.3629 M4 54 564688 C T
CDZ96566 X.sub.3630 M4 54 565396 T C
CDZ96567 X.sub.3631 M4 54 583996 G A
CDZ96570 X.sub.3632 M4 54 616268 A G
CDZ96581 X.sub.3633 M4 54 619019 G A
CDZ96580 X.sub.3634 M4 54 733193 T C
CDZ96619 X.sub.3635 M4 54 742842 C T
CDZ96621 X.sub.3636 M4 54 743396 G A
CDZ96621 X.sub.3637 M4 54 746707 G A
CDZ96623 X.sub.3638 M4 58 93 T C
X.sub.3639 M4 64 2756 A C
CDZ96626 X.sub.3640 M4 67 111 G A
X.sub.3641 M4 69 29006 G A
CED83534 X.sub.3642 M4 69 48869 G A
CED83542 X.sub.3643 M4 69 50642 C T
CED83543 X.sub.3644 M4 69 52428 G A
CED83541 X.sub.3645 M4 69 70304 C T
CED83551 X.sub.3646 M4 69 89393 G A
CED83556 X.sub.3647 M4 69 107920 C T
CED83561 X.sub.3648 M4 69 201005 G A
CED83595 X.sub.3649 M4 69 293602 G A
CED83626 X.sub.3650 M4 69 384418 G A
CED83656 X.sub.3651 M4 69 415659 C T
CED83665 X.sub.3652 M4 69 431248 G A
CED83671 X.sub.3653 M4 69 441238 C G
CED83674 X.sub.3654 M4 69 455639 G A
CED83677 X.sub.3655 M4 69 461986 G A
CED83680 X.sub.3656 M4 69 472563 C T
CED83681 X.sub.3657 M4 69 473113 G A
CED83684 X.sub.3658 M4 69 482073 G T
CED83685 X.sub.3659 M4 69 585845 G A
CED83722 X.sub.3660 M4 69 631511 G A
CED83742 X.sub.3661 M4 69 637299 T C
CED83744 X.sub.3662 M4 69 675579 G A
CED83760 X.sub.3663 M4 69 676581 G A
CED83760 X.sub.3664 M4 69 676853 G A
CED83759 X.sub.3665 M4 69 678406 C T
CED83759 X.sub.3666 M4 69 682770 C T
CED83763 X.sub.3667 M4 69 803358 G A
CED83798 X.sub.3668 M4 69 865820 C T
CED83814 X.sub.3669 M4 69 869706 G A
CED83815 X.sub.3670 M4 69 892199 G A
CED83822 X.sub.3671 M4 69 894462 C T
CED83821 X.sub.3672 M4 69 949982 C T
CED83842 X.sub.3673 M4 69 971219 C T
CED83847 X.sub.3674 M4 69 988364 G A
CED83857 X.sub.3675 M4 69 1038140 G A
CED83874 X.sub.3676 M4 69 1042212 G A
CED83875 X.sub.3677 M4 69 1080212 C T
CED83889 X.sub.3678 M4 69 1084824 G A
CED83891 X.sub.3679 M4 69 1084835 C T
CED83891 X.sub.3680 M4 69 1084848 A G
CED83891 X.sub.3681 M4 69 1084866 A G
CED83891 X.sub.3682 M4 69 1084931 C T
CED83891 X.sub.3683 M4 69 1102164 C T
CED83897 X.sub.3684 M4 69 1109785 C T
CED83899 X.sub.3685 M4 69 1109813 A G
CED83899 X.sub.3686 M4 69 1109818 A G
CED83899 X.sub.3687 M4 69 1109819 T A
CED83899 X.sub.3688 M4 69 1109823 T C
CED83899 X.sub.3689 M4 69 1109830 A G
CED83899 X.sub.3690 M4 69 1109831 C A
CED83899 X.sub.3691 M4 69 1109835 A G
CED83899 X.sub.3692 M4 69 1110489 T A
CED83899 X.sub.3693 M4 69 1110507 A T
CED83899 X.sub.3694 M4 69 1110521 A C
CED83899 X.sub.3695 M4 69 1115486 C T
CED83902 X.sub.3696 M4 69 1152012 g A
CED83915 X.sub.3697 M4 69 1161041 A G
CED83918 X.sub.3698 M4 69 1205454 C T
CED83932 X.sub.3699 M4 69 1218409 G A
CED83936 X.sub.3700 M4 69 1245509 C T
CED83943 X.sub.3701 M4 69 1260087 G A
CED83949 X.sub.3702 M4 69 1342909 G A
CED83975 X.sub.3703 M4 69 1356844 C t
CED83982 X.sub.3704 M4 69 1372486 C T
CED83987 X.sub.3705 M4 69 1379683 C T
CED83991 X.sub.3706 M4 69 1411237 C T
CED84001 X.sub.3707 M4 69 1411421 C T
CED83999 X.sub.3708 M4 69 1421240 C T
CED84004 X.sub.3709 M4 69 1430120 C T
CED84006 X.sub.3710 M4 69 1485040 G A
CED84023 X.sub.3711 M4 69 1493453 C T
CED84026 X.sub.3712 M4 69 1590302 G A
CED84059 X.sub.3713 M4 69 1601173 c T
CED84062 X.sub.3714 M4 69 1636638 C T
CED84073 X.sub.3715 M4 69 1652288 C T
CED84077 X.sub.3716 M4 69 1674261 C T
CED84084 X.sub.3717 M4 69 1688555 C T
CED84088 X.sub.3718 M4 69 1694047 C T
CED84089 X.sub.3719 M4 69 1714728 G A
CED84097 X.sub.3720 M4 69 1790823 C T
CED84125 X.sub.3721 m4 69 1792597 C T
CED84126 X.sub.3722 M4 69 1800584 G A
CED84129 X.sub.3723 M4 69 1853510 T C
CED84145 X.sub.3724 M4 69 1854739 G A
CED84145 X.sub.3725 M4 69 1924621 C T
CED84172 X.sub.3726 M4 69 1967529 C T
CED84189 X.sub.3727 M4 69 1968848 A G
CED84189 X.sub.3728 M4 69 2001469 C T
CED84197 X.sub.3729 M4 69 2009058 G A
CED84201 X.sub.3730 M4 69 2031440 G A
CED84210 X.sub.3731 M4 69 2038266 G A
CED84211 X.sub.3732 M4 69 2099556 C T
CED84233 X.sub.3733 M4 69 2099559 A T
CED84233 X.sub.3734 M4 69 2113590 G A
CED84237 X.sub.3735 M4 69 2156050 C T
CED84252 X.sub.3736 M4 69 2160207 C T
CED84255 X.sub.3737 M4 69 2219444 G A
CED84271 X.sub.3738 M4 69 2226113 C T
CED84272 X.sub.3739 M4 69 2226317 C T
CED84272 X.sub.3740 M4 69 2260222 C T
CED84282 X.sub.3741 M4 69 2275703 G A
CED84290 X.sub.3742 M4 69 2402826 C T
CED84333 X.sub.3743 M4 69 2438727 C T
CED84343 X.sub.3744 M4 69 2440765 C A
CED84343 X.sub.3745 M4 69 2448630 C T
CED84344 X.sub.3746 M4 69 2483433 G A
CED84352 X.sub.3747 M4 72 93 T C
X.sub.3748 M4 72 584 G A
X.sub.3749 M4 72 856 C T
X.sub.3750 M4 72 1163 C T
X.sub.3751 M4 77 18912 A G
CDZ96635 X.sub.3752 M4 77 34978 G T
CDZ96642 X.sub.3753 M4 77 39842 G A
CDZ96646 X.sub.3754 M4 77 65419 G A
CDZ96655 X.sub.3755 M4 77 84022 G A
CDZ96659 X.sub.3756 M4 78 1865 C T
CED84359 X.sub.3757 M4 78 6333 G A
CED84360 X.sub.3758 M4 78 21716 C T
CED84364 X.sub.3759 M4 78 89958 C T
CED84387 X.sub.3760 M4 78 158534 G A
CED84406 X.sub.3761 M4 78 191358 G A
CED84414 X.sub.3762 M4 78 233543 T C
CED84431 X.sub.3763 M4 78 238854 C T
CED84430 X.sub.3764 M4 78 263828 T C
CED84438 X.sub.3765 M4 78 281454 C A
CED84441 X.sub.3766 M4 78 298141 C G
CED84443 X.sub.3767 M4 78 299644 G A
CED84443 X.sub.3768 M4 78 301815 T C
CED84443 X.sub.3769 M4 78 302700 A G
CED84443 X.sub.3770 M4 78 333312 A G
CED84452 X.sub.3771 M4 78 415432 G A
CED84479 X.sub.3772 M4 78 444292 C T
CED84490 X.sub.3773 M4 78 462728 G A
CED84497 X.sub.3774 M4 78 506703 G A
CED84508 X.sub.3775 M4 78 626958 C A
CED84549 X.sub.3776 M4 78 631891 C T
CED84551 X.sub.3777 M4 78 658932 G A
CED84561 X.sub.3778 M4 78 708376 C T
CED84580 X.sub.3779 M4 78 715700 G A
CED84582 X.sub.3780 M4 78 763771 G A
CED84600 X.sub.3781 M4 78 774252 G A
CED84602 X.sub.3782 M4 78 875825 C T
CED84633 X.sub.3783 M4 78 895505 C T
CED84642 X.sub.3784 M4 78 904287 G A
CED84646 X.sub.3785 M4 78 905457 A G
CED84645 X.sub.3786 M4 78 952815 G A
CED84662 X.sub.3787 M4 78 952860 G A
CED84662 X.sub.3788 M4 78 1023381 G A
CED84688 X.sub.3789 M4 78 1067609 G A
CED84705 X.sub.3790 M4 78 1086537 C T
CED84713 X.sub.3791 M4 78 1095322 C T
CED84715 X.sub.3792 M4 78 1111002 G A
CED84721 X.sub.3793 M4 78 1115511 G A
CED84723 X.sub.3794 M4 78 1118856 C T
CED84724 X.sub.3795 M4 78 1199323 C T
CED84746 X.sub.3796 M4 78 1213556 G A
CED84752 X.sub.3797 M4 78 1216573 C T
CED84752 X.sub.3798 M4 78 1247678 C T
CED84761 X.sub.3799 M4 78 1302286 C T
CED84782 X.sub.3800 M4 78 1315648 C T
CED84788 X.sub.3801 M4 78 1317124 G A
CED84787 X.sub.3802 M4 78 1344640 C T
CED84795 X.sub.3803 M4 78 1360288 G A
CED84802 X.sub.3804 M4 78 1382780 G A
CED84812 X.sub.3805 M4 78 1397982 G A
CED84818 X.sub.3806 M4 78 1410781 G A
CED84825 X.sub.3807 M4 78 1426722 C T
CED84829 X.sub.3808 M4 78 1475803 G A
CED84845 X.sub.3809 M4 78 1532973 G A
CED84857 X.sub.3810 M4 78 1563246 C T
CED84865 X.sub.3811 M4 78 1568326 C T
CED84868 X.sub.3812 M4 78 1578844 G A
CED84871 X.sub.3813 M4 78 1609850 C T
CED84880 X.sub.3814 M4 78 1642170 G A
CED84889 X.sub.3815 M4 78 1660408 G A
CED84897 X.sub.3816 M4 78 1673601 C T
CED84903 X.sub.3817 M4 78 1709344 G A
CED84917 X.sub.3818 M4 78 1742796 G A
CED84926 X.sub.3819 M4 79 65 G A
CDZ96674 X.sub.3820 M4 79 6477 T C
CDZ96674- CDZ96675 X.sub.3821 M4 79 57804 G A
CDZ96687 X.sub.3822 M4 79 64658 C T
CDZ96688 X.sub.3823 M4 79 65402 C T
CDZ96688 X.sub.3824 M4 79 132683 C T
CDZ96713 X.sub.3825 M4 79 147578 G A
CDZ96719 X.sub.3826 M4 79 255780 G A
CDZ96757 X.sub.3827 M4 79 281783 C T
CDZ96768 X.sub.3828 M4 79 307021 C T
CDZ96777 X.sub.3829 M4 79 345646 G A
CDZ96789 X.sub.3830 M4 79 346823 G A
CDZ96789 X.sub.3831 M4 79 368176 G A
CDZ96795 X.sub.3832 M4 79 406184 G A
CDZ96808 X.sub.3833 M4 79 412057 T C
CDZ96811 X.sub.3834 M4 79 412661 G A
CDZ96811 X.sub.3835 M4 79 492523 C T
CDZ96842 X.sub.3836 M4 79 526910 C T
CDZ96854 X.sub.3837 M4 79 552798 C T
CDZ96861 X.sub.3838 M4 79 573293 C T
CDZ96868 X.sub.3839 M4 79 575411 C T
CDZ96868 X.sub.3840 M4 79 579674 G A
CDZ96871 X.sub.3841 M4 79 611702 C T
CDZ96881 X.sub.3842 M4 79 617057 C T
CDZ96882 X.sub.3843 M4 79 679140 C T
CDZ96904 X.sub.3844 M4 79 696174 G A
CDZ96911 X.sub.3845 M4 79 735053 T C
CDZ96928 X.sub.3846 M4 79 748083 G T
CDZ96929 X.sub.3847 M4 79 758025 G A
CDZ96931 X.sub.3848 M4 79 759403 C T
CDZ96931 X.sub.3849 M4 79 759589 G A
CDZ96932 X.sub.3850 M4 79 759659 G A
CDZ96931 X.sub.3851 M4 79 760430 T C
CDZ96932 X.sub.3852 M4 79 760458 G T
CDZ96932 X.sub.3853 M4 79 760541 A G
CDZ96932 X.sub.3854 M4 79 760891 A G
CDZ96932 X.sub.3855 M4 79 760988 G T
CDZ96932 X.sub.3856 M4 79 761056 T C
CDZ96932 X.sub.3857 M4 79 761210 T C
CDZ96932 X.sub.3858 M4 79 768537 A G
CDZ96933 X.sub.3859 M4 79 786064 A G
CDZ96934 X.sub.3860 M4 79 798799 C T
CDZ96939 X.sub.3861 M4 79 830724 C G
CDZ96950 X.sub.3862 M4 79 874161 G A
CDZ96965 X.sub.3863 M4 79 907000 C T
CDZ96976 X.sub.3864 M4 79 908162 G A
CDZ96976 X.sub.3865 M4 79 914302 C T
CDZ96977 X.sub.3866 M4 79 920544 C T
CDZ96982 X.sub.3867 M4 79 922582 G A
CDZ96983 X.sub.3868 M4 79 933234 G A
CDZ96987 X.sub.3869 M4 79 940003 C T
CDZ96991 X.sub.3970 M4 79 962607 G A
CDZ96997 X.sub.3871 M4 79 973493 C T
CDZ97000 X.sub.3872 M4 79 1000786 A G
CDZ97007 X.sub.3873 M4 79 1021855 G A
CDZ97016 X.sub.3874 M4 79 1082233 G A
CDZ97037 X.sub.3875 M4 79 1107695 C T
CDZ97046 X.sub.3876 M4 79 1117040 C T
CDZ97047 X.sub.3877 M4 79 1118598 C T
CDZ97048 X.sub.3878 M4 79 1123288 C T
CDZ97049 X.sub.3879 M4 79 1140763 G A
CDZ97053 X.sub.3880 M4 79 1151678 C T
CDZ97060 X.sub.3881 M4 79 1176587 T A
CDZ97066 X.sub.3882 M4 79 1229129 G A
CDZ97086 X.sub.3883 M4 79 1231740 C T
CDZ97087 X.sub.3884 M4 79 1286778 T C
CDZ97106 X.sub.3885 M4 79 1302166 G A
CDZ97112 X.sub.3886 M4 79 1318034 C T
CDZ97117 X.sub.3887 M4 79 1336766 C T
CDZ97121 X.sub.3888 M4 79 1344403 C T
CDZ97124 X.sub.3889 M4 79 1430954 G A
CDZ97152 X.sub.3890 M4 79 1447480 G A
CDZ97156 X.sub.3891 M4 79 1472351 C T
CDZ97165 X.sub.3892 M4 79 1540205 C T
CDZ97186 X.sub.3893 M4 79 1624415 G A
CDZ97217 X.sub.3894 M4 79 1674448 G A
CDZ97228 X.sub.3895 M4 79 1677774 C T
CDZ97229 X.sub.3896 M4 79 1696776 G A
CDZ97234 X.sub.3897 M4 79 1788096 G A
CDZ97262 X.sub.3898 M4 79 1791482 G A
CDZ97263 X.sub.3899 M4 79 1797660 C T
CDZ97265 X.sub.3900 M4 79 1797676 G A
CDZ97265 X.sub.3901 M4 79 1819746 C T
CDZ97273 X.sub.3902 M4 79 1842448 G A
CDZ97282 X.sub.3903 M4 79 1855037 A G
CDZ97285 X.sub.3904 M4 79 1859220 A G
CDZ97291 X.sub.3905 M4 79 1877329 G A
CDZ97295 X.sub.3906 M4 79 1883004 A G
CDZ97298 X.sub.3907 M4 79 1883021 C A
CDZ97298 X.sub.3908 M4 79 1883115 T C
CDZ97298 X.sub.3909 M4 79 1912360 G A
CDZ97307 X.sub.3910 M4 79 1934434 G A
CDZ97316 X.sub.3911 M4 79 2013304 G A
CDZ97344 X.sub.3912 M4 79 2013361 C T
CDZ97344 X.sub.3913 M4 79 2115870 G A
CDZ97380 X.sub.3914 M4 79 2121041 G A
CDZ97380 X.sub.3915 M4 79 2152573 C T
CDZ97392 X.sub.3916 M4 79 2182096 G A
CDZ97403 X.sub.3917 M4 79 2188410 G A
CDZ97405 X.sub.3918 M4 79 2220254 C T
CDZ97414 X.sub.3919 M4 79 2268540 C T
CDZ97435 X.sub.3920 M4 79 2315869 A C
CDZ97452 X.sub.3921 M4 79 2339881 C G
CDZ97460 X.sub.3922 M4 79 2340326 G A
CDZ97462 X.sub.3923 M4 79 2340636 T C
CDZ97462 X.sub.3924 M4 85 512 A G
X.sub.3925 M4 85 516 G A
X.sub.3926 M4 85 521 C T
X.sub.3927 M4 85 522 A G
X.sub.3928 M4 88 119 C T
CDZ97464 X.sub.3929 M4 88 196 G A
CDZ97464 X.sub.3930 M4 88 898 C T
CDZ97464 X.sub.3931 M4 99 245 G A
X.sub.3932 M4 105 258 A G
CDZ97474 X.sub.3933 M4 105 429 C T
CDZ97474 X.sub.3934 M4 109 396 T C
X.sub.3935 M4 118 396 C T
CDZ97478 X.sub.3936 M4 118 870 G A
CDZ97478 X.sub.3937 M4 118 1491 G A
CDZ97478 X.sub.3938 M4 121 452 G A
X.sub.3939 M4 121 907 T C
X.sub.3940 M4 124 65147 C T
CDZ97499 X.sub.3941 M4 124 72117 G A
CDZ97501 X.sub.3942 M4 124 72760 G A
CDZ97501 X.sub.3943 M4 124 76965 A T
CDZ97503 X.sub.3944 M4 124 94611 G A
CDZ97507 X.sub.3945 M4 124 111749 G A
CDZ97512 X.sub.3946 M4 124 156052 G A
CDZ97524 X.sub.3947 M4 124 166988 C T
CDZ97527 X.sub.3948 M4 124 206541 G A
CDZ97541 X.sub.3949 M4 124 207992 C T
CDZ97541 X.sub.3950 M4 124 222249 C T
CDZ97547 X.sub.3951 M4 125 16379 G A
CDZ97565 X.sub.3952 M4 125 35864 T C
CDZ97573 X.sub.3953 M4 127 1558 T C
X.sub.3954 M4 129 299 G A
CDZ97577 X.sub.3955 M4 129 433 G A
CDZ97577 X.sub.3956 M4 129 856 G A
CDZ97577 X.sub.3957 M4 129 1013 C T
CDZ97577 X.sub.3958 M4 130 67 C T
CDZ97578 X.sub.3959 M4 141 15764 C T
CDZ97587 X.sub.3960 M4 149 1663 A G
CDZ97598 X.sub.3961 M4 149 2074 T G
CDZ97598 X.sub.3962 M4 149 2453 C T
CDZ97598 X.sub.3963 M4 159 106 A C
X.sub.3964 M4 162 47699 G A
CDZ97619 X.sub.3965 M4 162 68192 C G
CDZ97625 X.sub.3966 M4 162 70405 A G
CDZ97625 X.sub.3967 M4 162 91190 C T
CDZ97631 X.sub.3968 M4 162 96194 G A
CDZ97631 X.sub.3969 M4 162 112967 C T
CDZ97638 X.sub.3970 M4 162 117736 G A
CDZ97639 X.sub.3971 M4 162 223407 C T
CDZ97674 X.sub.3972 M4 162 231146 C T
CDZ97676 X.sub.3973 M4 162 233092 C T
CDZ97676 X.sub.3974 M4 162 238126 C T
CDZ97680 X.sub.3975 M4 162 243753 G A
CDZ97680 X.sub.3976 M4 162 308369 T C
CDZ97702 X.sub.3977 M4 162 320701 G A
CDZ97703 X.sub.3978 M4 162 321460 C G
CDZ97703 X.sub.3979 M4 162 321463 A C
CDZ97703 X.sub.3980 M4 162 322591 G A
CDZ97703 X.sub.3981 M4 162 323448 T G
CDZ97703 X.sub.3982 M4 162 323451 T G
CDZ97703 X.sub.3983 M4 162 324114 T C
CDZ97703 X.sub.3984 M4 162 324139 C T
CDZ97703 X.sub.3985 M4 162 324568 A G
CDZ97703 X.sub.3986 M4 162 351016 C T
CDZ97711 X.sub.3987 M4 162 360320 G A
CDZ97714 X.sub.3988 M4 162 398165 C T
CDZ97730 X.sub.3989 M4 162 408274 C T
CDZ97733 X.sub.3990 M4 162 424391 C T
CDZ97740 X.sub.3991 M4 162 444123 T C
CDZ97748 X.sub.3992 M4 162 453186 G A
CDZ97750 X.sub.3993 M4 162 456498 C T
CDZ97752 X.sub.3994 M4 162 467207 C T
CDZ97755 X.sub.3995 M4 162 476267 C T
CDZ97760 X.sub.3996 M4 162 480722 G A
CDZ97761 X.sub.3997 M4 162 491906 G A
CDZ97764 X.sub.3998 M4 162 492101 G A
CDZ97764 X.sub.3999 M4 162 501886 C T
CDZ97769 X.sub.4000 M4 162 618658 C T
CDZ97808 X.sub.4001 M4 162 631700 G A
CDZ97811 X.sub.4002 M4 162 632311 G A
CDZ97814 X.sub.4003 M4 162 633321 G A
CDZ97814 X.sub.4004 M4 162 633633 G A
CDZ97814 X.sub.4005 M4 162 640005 C T
CDZ97815 X.sub.4006 M4 162 645194 G A
CDZ97815 X.sub.4007 M4 162 690472 C T
CDZ97827 X.sub.4008 M4 162 738479 G A
CDZ97842 X.sub.4009 M4 162 738675 G A
CDZ97842 X.sub.4010 M4 162 738686 C T
CDZ97842 X.sub.4011 M4 162 808830 G A
CDZ97869 X.sub.4012 M4 162 825209 G A
CDZ97877 X.sub.4013 M4 162 841825 A G
CDZ97882 X.sub.4014 M4 162 871911 C T
CDZ97890 X.sub.4015 M4 162 967098 A G
CDZ97922 X.sub.4016 M4 162 972973 G A
CDZ97925 X.sub.4017 M4 163 727 A G
X.sub.4018 M4 169 1056 C T
X.sub.4019 M4 189 12794 C T
CDZ97963 X.sub.4020 M4 189 126573 G A
CDZ97996 X.sub.4021 M4 189 127854 C T
CDZ97998 X.sub.4022 M4 189 194647 A G
CDZ98020 X.sub.4023 M4 189 194665 A G
CDZ98020 X.sub.4024 M4 189 211865 C T
CDZ98028 X.sub.4025 M4 189 260617 A T
CDZ98041 X.sub.4026 M4 189 300343 C T
CDZ98056 X.sub.4027 M4 189 303106 G A
CDZ98057 X.sub.4028 M4 189 323680 C T
CDZ98063 X.sub.4029 M4 189 344057 C T
CDZ98068 X.sub.4030 M4 189 371247 G A
CDZ98078 X.sub.4031 M4 189 452298 G A
CDZ98106 X.sub.4032 M4 191 342 A G
CDZ98107 X.sub.4033 M4 191 347 C T
CDZ98107 X.sub.4034 M4 191 427 C T
CDZ98107 X.sub.4035 M4 191 451 C T
CDZ98107 X.sub.4036 M4 191 487 A G
CDZ98107 X.sub.4037 M4 197 624 C T
CDZ98111 X.sub.4038 M4 198 202 C A
X.sub.4039 M4 198 203 G A
X.sub.4040 M4 198 238 C T
X.sub.4041 M4 198 265 C T
X.sub.4042 M4 198 452 G A
X.sub.4043 M4 199 688 C T
X.sub.4044 M4 199 911 C T
X.sub.4045 M4 199 971 C T
X.sub.4046 M4 199 1218 C T
X.sub.4047 M4 202 171 C T
X.sub.4048 M4 205 360 C T
CDZ98112 X.sub.4049 M4 205 981 C T
CDZ98112 X.sub.4050 M4 206 406 G A
X.sub.4051 M4 208 117 G A
X.sub.4052 M4 208 476 G A
X.sub.4053 M4 208 616 G A
X.sub.4054 M4 208 935 G A
X.sub.4055 M4 209 312 C T
CDZ98113 X.sub.4056 M4 214 197 C G
CDZ98116 X.sub.4057 M4 220 116 C G
X.sub.4058 M4 223 93 G A
CDZ98118 X.sub.4059 M4 223 102 A G
CDZ98118 X.sub.4060 M4 223 133 A G
CDZ98118 X.sub.4061 M4 223 150 T C
CDZ98118 X.sub.4062 M4 223 155 A C
CDZ98118 X.sub.4063 M4 223 158 T C
CDZ98118 X.sub.4064 M4 223 160 C T
CDZ98118 X.sub.4065 M4 223 175 G A
CDZ98118 X.sub.4066 M4 223 177 A G
CDZ98118 X.sub.4067 M4 223 188 A G
CDZ98118 X.sub.4068 M4 223 192 C A
CDZ98118 X.sub.4069 M4 223 194 T C
CDZ98118 X.sub.4070 M4 223 195 T G
CDZ98118 X.sub.4071 M4 223 197 T C
CDZ98118 X.sub.4072 M4 223 202 G C
CDZ98118 X.sub.4073 M4 223 205 C T
CDZ98118 X.sub.4074 M4 224 27 T A
X.sub.4075 M4 225 317 C T
X.sub.4076 M4 227 202 G A
X.sub.4077 M4 232 340 G A
CDZ98119 X.sub.4078 M4 232 1379 C T
CDZ98119 X.sub.4079 M4 232 1521 C T
CDZ98119 X.sub.4080 M4 232 1662 G A
CDZ98119 X.sub.4081 M4 232 1761 C T
CDZ98119 X.sub.4082 M4 232 2027 C T
CDZ98119 X.sub.4083 M4 232 3060 C T
CDZ98120 X.sub.4084 M4 232 3284 C T
CDZ98119 X.sub.4085 M4 232 4437 G A
CDZ98121 X.sub.4086 M4 232 4561 C T
CDZ98120 X.sub.4087 M4 242 7334 C T
CDZ98125 X.sub.4088 M4 242 41710 G A
CDZ98131 X.sub.4089 M4 242 50262 G A
CDZ98135 X.sub.4090 M4 242 107587 G A
CDZ98153 X.sub.4091 M4 242 213399 C T
CDZ98185 X.sub.4092 M4 242 213986 G A
CDZ98185 X.sub.4093 M4 242 227271 C T
CDZ98191 X.sub.4094 M4 242 233088 G A
CDZ98193 X.sub.4095 M4 242 310353 G A
CDZ98216 X.sub.4096 M4 242 357209 G A
CDZ98233 X.sub.4097 M4 242 404132 G A
CDZ98248 X.sub.4098 M4 242 412676 G A
CDZ98249 X.sub.4099 M4 242 437941 G A
CDZ98258 X.sub.4100 M4 242 454709 C T
CDZ98263 X.sub.4101 M4 242 485936 G A
CDZ98270 X.sub.4102 M4 242 492389 G A
CDZ98274 X.sub.4103 M4 242 514780 C T
CDZ98282 X.sub.4104 M4 242 528340 G A
CDZ98288 X.sub.4105 M4 242 542663 G A
CDZ98290 X.sub.4106 M4 242 559999 G A
CDZ98297 X.sub.4107 M4 242 577367 G A
CDZ98302 X.sub.4108 M4 242 602456 G A
CDZ98308 X.sub.4109 M4 242 602531 G A
CDZ98308 X.sub.4110 M4 242 604704 C T
CDZ98309 X.sub.4111 M4 242 641669 G A
CDZ98323 X.sub.4112 M4 248 99 A G
X.sub.4113 M4 249 42295 C T
CED84942 X.sub.4114 M4 249 72016 C T
CED84950 X.sub.4115 M4 249 157550 C T
CED84983 X.sub.4116 M4 249 191304 C T
CED84988 X.sub.4117 M4 249 253494 C T
CED85008 X.sub.4118 M4 249 272075 C T
CED85013 X.sub.4119 M4 249 305975 G A
CED85023 X.sub.4120 M4 249 311154 G A
CED85025 X.sub.4121 M4 249 342990 G A
CED85036 X.sub.4122 M4 249 370636 T C
CED85048 X.sub.4123 M4 249 371535 G A
CED85048 X.sub.4124 M4 249 377814 G A
CED85051 X.sub.4125 M4 249 445429 G A
CED85075 X.sub.4126 M4 249 469645 G A
CED85087 X.sub.4127 M4 249 485782 C T
CED85089 X.sub.4128 M4 249 501310 C T
CED85093 X.sub.4129 M4 249 501510 T C
CED85093 X.sub.4130 M4 249 506067 A G
CED85094 X.sub.4131 M4 249 532943 A G
CED85099 X.sub.4132 M4 249 571922 C T
CED85115 X.sub.4133 M4 249 576070 G A
CED85118 X.sub.4134 M4 249 598579 C T
CED85125 X.sub.4135 M4 249 627104 C T
CED85133 X.sub.4136 M4 249 637944 G A
CED85135 X.sub.4137 M4 249 660408 G A
CED85144 X.sub.4138 M4 249 709267 C T
CED85162 X.sub.4139 M4 249 746655 C T
CED85172 X.sub.4140 M4 249 854220 G A
CED85201 X.sub.4141 M4 249 886063 G A
CED85208 X.sub.4142 M4 249 911274 C T
CED85218 X.sub.4143 M4 249 932606 C T
CED85223 X.sub.4144 M4 249 945434 C T
CED85227 X.sub.4145 M4 249 945727 C T
CED85227 X.sub.4146 M4 249 969333 G T
CED85238 X.sub.4147 M4 249 972975 G A
CED85240 X.sub.4148 M4 249 977170 C T
CED85242 X.sub.4149 M4 249 989520 C T
CED85243 X.sub.4150 M4 249 1003476 G A
CED85249 X.sub.4151 M4 249 1014098 C T
CED85252 X.sub.4152 M4 249 1062282 G A
CED85266 X.sub.4153 M4 249 1064359 C T
CED85265 X.sub.4154 M4 249 1076333 G A
CED85270 X.sub.4155 M4 249 1088841 T C
CED85274 X.sub.4156 M4 249 1127638 C T
CED85286 X.sub.4157 M4 249 1143228 C T
CED85292 X.sub.4158 M4 249 1144309 G A
CED85291 X.sub.4159 M4 249 1176977 G A
CED85303 X.sub.4160 M4 24 1195367 G A
CED85307 X.sub.4161 M4 24 1223330 C T
CED85317 X.sub.4162 M4 249 1230068 C T
CED85319 X.sub.4163 M4 249 1279596 C T
CED85335 X.sub.4164 M4 249 1299472 C T
CED85343 X.sub.4165 M4 249 1498029 T C
CED85415 X.sub.4166 M4 249 1498823 T C
CED85414 X.sub.4167 M4 249 1498829 C T
CED85414 X.sub.4168 M4 249 1499004 T C
CED85415 X.sub.4169 M4 249 1499008 A G
CED85415 X.sub.4170 M4 249 1502631 G T
CED85416 X.sub.4171 M4 249 1502641 T A
CED85416 X.sub.4172 M4 249 1502819 T G
CED85416 X.sub.4173 M4 249 1505138 G A
CED85416 X.sub.4174 M4 249 1518591 T A
CED85419 X.sub.4175 M4 249 1519431 A G
CED85419 X.sub.4176 M4 249 1535511 G A
CED85423 X.sub.4177 M4 249 1619036 G A
CED85450 X.sub.4178 M4 249 1621516 G A
CED85451 X.sub.4179 M4 249 1623151 G A
CED85451 X.sub.4180 M4 249 1653615 T G
CED85457 X.sub.4181 M4 249 1653962 C T
CED85458 X.sub.4182 M4 249 1666185 C T
CED85460 X.sub.4183 M4 249 1691321 G A
CED85467 X.sub.4184 M4 249 1726777 C T
CED85474 X.sub.4185 M4 249 1730645 C T
CED85477 X.sub.4186 M4 249 1734722 G A
CED85477 X.sub.4187 M4 249 1741408 C T
CED85480 X.sub.4188 M4 249 1780551 A G
CED85493 X.sub.4189 M4 249 1780569 A G
CED85493 X.sub.4190 M4 249 1801965 G A
CED85501 X.sub.4191 M4 249 1803575 C T
CED85502 X.sub.4192 M4 249 1803790 G A
CED85502 X.sub.4193 M4 249 1880762 G A
CED85525 X.sub.4194 M4 249 1915336 C T
CED85537 X.sub.4195 M4 249 1944026 G A
CED85545 X.sub.4196 M4 249 1977554 G A
CED85556 X.sub.4197 M4 249 1981230 G A
CED85557 X.sub.4198 M4 249 1988505 C T
CED85560 X.sub.4199 M4 249 2010712 G A
CED85564 X.sub.4200 M4 249 2015272 G A
CED85567 X.sub.4201 M4 249 2027477 G A
CED85573 X.sub.4202 M4 249 2063221 G A
CED85586 X.sub.4203 M4 249 2110956 C T
CED85603 X.sub.4204 M4 249 2124517 C T
CED85607 X.sub.4205 M4 249 2178506 G A
CED85622 X.sub.4206 M4 249 2198205 G A
CED85628 X.sub.4207 M4 249 2198412 G A
CED85628 X.sub.4208 M4 249 2223626 G A
CED85633 X.sub.4209 M4 249 2254072 G A
CED85640 X.sub.4210 M4 249 2255547 G C
CED85640 X.sub.4211 M4 251 1089 T C
X.sub.4212 M4 251 1135 G A
X.sub.4213 M4 252 512 C T
X.sub.4214 M4 252 524 C T
X.sub.4215 M4 258 1139 A T
X.sub.4216 M4 260 156 G A
X.sub.4217 M4 262 4049 G A
CDZ98330 X.sub.4218 M4 262 16863 C T
CDZ98334 X.sub.4219 M4 262 30347 G A
CDZ98338 X.sub.4220 M4 262 30359 G A
CDZ98338 X.sub.4221 M4 262 81226 G A
CDZ98358 X.sub.4222 M4 262 108865 C T
CDZ98369 X.sub.4223 M4 262 109833 C T
CDZ98369 X.sub.4224 M4 262 134217 G A
CDZ98371 X.sub.4225 M4 262 148151 C T
CDZ98375 X.sub.4226 M4 262 164438 G A
CDZ98383 X.sub.4227 M4 262 175142 G A
CDZ98388 X.sub.4228 M4 262 201531 G A
CDZ98396 X.sub.4229 M4 262 221937 C T
CDZ98403 X.sub.4230 M4 262 286191 C T
CDZ98425 X.sub.4231 M4 262 286196 T A
CDZ98425 X.sub.4232 M4 262 319302 G A
CDZ98436 X.sub.4233 M4 262 380519 C T
CDZ98457 X.sub.4234 M4 262 383215 C T
CDZ98459 X.sub.4235 M4 262 392930 C T
CDZ98461 X.sub.4236 M4 262 397539 G A
CDZ98463 X.sub.4237 M4 262 414403 C T
CDZ98467 X.sub.4238 M4 262 420102 G A
CDZ98468 X.sub.4239 M4 262 444331 G A
CDZ98477 X.sub.4240 M4 262 446956 C T
CDZ98477 X.sub.4241 M4 262 539428 G A
CDZ98514 X.sub.4242 M4 262 539452 A G
CDZ98514 X.sub.4243 M4 262 539470 A G
CDZ98514 X.sub.4244 M4 262 557280 G A
CDZ98518 X.sub.4245 M4 262 560713 G A
CDZ98519 X.sub.4246 M4 262 562795 C T
CDZ98521 X.sub.4247 M4 262 567591 G A
CDZ98524 X.sub.4248 M4 262 567801 G A
CDZ98524 X.sub.4249 M4 262 573667 C T
CDZ98526 X.sub.4250 M4 262 618198 G A
CDZ98538 X.sub.4251 M4 262 638804 G C
CDZ98544 X.sub.4252 M4 262 639869 G C
CDZ98544 X.sub.4253 M4 262 639962 A G
CDZ98544 X.sub.4254 M4 262 653920 A G
CDZ98545 X.sub.4255 M4 262 655754 A T
CDZ98545 X.sub.4256 M4 262 655757 T C
CDZ98545 X.sub.4257 M4 262 656031 C A
CDZ98545 X.sub.4258 M4 262 668764 C T
CDZ98545 X.sub.4259 M4 262 673556 G A
CDZ98548 X.sub.4260 M4 262 691577 C T
CDZ98551 X.sub.4261 M4 262 822734 G A
CDZ98597 X.sub.4262 M4 262 835874 C T
CDZ98601 X.sub.4263 M4 262 865999 G A
CDZ98613 X.sub.4264 M4 262 969192 G A
CDZ98649 X.sub.4265 M4 262 971713 G A
CDZ98649 X.sub.4266 M4 262 1011054 G A
CDZ98659 X.sub.4267 M4 262 1051389 C T
CDZ98670 X.sub.4268 M4 262 1060326 C T
CDZ98672 X.sub.4269 M4 262 1076581 G A
CDZ98679 X.sub.4270 M4 262 1140198 C T
CDZ98701 X.sub.4271 M4 262 1169777 G A
CDZ98710 X.sub.4272 M4 262 1209662 G A
CDZ98723 X.sub.4273 M4 262 1226072 C T
CDZ98730 X.sub.4274 M4 262 1248058 C T
CDZ98737 X.sub.4275 M4 262 1257961 C T
CDZ98739 X.sub.4276 M4 262 1277604 G A
CDZ98747 X.sub.4277 M4 262 1305361 G A
CDZ98753 X.sub.4278 M4 262 1329643 C T
CDZ98760 X.sub.4279 M4 262 1350321 G A
CDZ98766 X.sub.4280 M4 262 1351116 A G
CDZ98766 X.sub.4281 M4 262 1415479 C T
CDZ98789 X.sub.4282 M4 262 1424293 G A
CDZ98791 X.sub.4283 M4 262 1455677 G A
CDZ98804 X.sub.4284 M4 262 1458863 C T
CDZ98807 X.sub.4285 M4 262 1550311 C T
CDZ98836 X.sub.4286 M4 262 1550456 C T
CDZ98837 X.sub.4287 M4 262 1577316 G A
CDZ98844 X.sub.4288 M4 262 1615762 G A
CDZ98855 X.sub.4289 M4 262 1677620 G A
CDZ98873 X.sub.4290 M4 262 1694625 C T
CDZ98878 X.sub.4291 M4 262 1711527 G A
CDZ98886 X.sub.4292 M4 262 1716385 G A
CDZ98887 X.sub.4293 M4 266 85 C T
X.sub.4294 M4 266 252 C T
X.sub.4295 M4 267 133 T C
X.sub.4296 M4 267 134 c T
X.sub.4297 M4 267 254 G T
X.sub.4298 M4 267 256 A G
X.sub.4299 M4 267 257 T C
X.sub.4300 M5 22 1643 C T
CED80056 X.sub.4301 M5 22 2524 G A
CED80056 X.sub.4302 M5 28 236 G A
CDZ96150 X.sub.4303 M5 28 377 G A
CDZ96150 X.sub.4304 M5 28 1506 C T
CDZ96150 X.sub.4305 M5 28 1677 C T
CDZ96150 X.sub.4306 M5 43 464 G A
CDZ96151 X.sub.4307 M5 43 753 C T
CDZ96151 X.sub.4308 M5 43 757 G A
CDZ96151 X.sub.4309 M5 43 1527 C T
CDZ96151 X.sub.4310 M5 43 1748 G A
CDZ96151 X.sub.4311 M5 43 1928 C T
CDZ96151 X.sub.4312 M5 62 26 T A
CDZ96152 X.sub.4313 M5 62 27 T C
CDZ96152 X.sub.4314 M5 62 55 T A
CDZ96152 X.sub.4315 M5 62 403 C T
CDZ96152 X.sub.4316 M5 62 875 G A
CDZ96152 X.sub.4317 M5 102 339 C T
CDZ96153 X.sub.4318 M5 102 951 G A
CDZ96153 X.sub.4319 M5 102 1042 G A
CDZ96153 X.sub.4320 M5 102 2334 G A
CDZ96153 X.sub.4321 M5 102 2590 C T
CDZ96153 X.sub.4322 M5 102 3427 C T
CDZ96153 X.sub.4323 M5 176 358 G A
CED80058 X.sub.4324 M5 176 1872 G A
CED80058 X.sub.4325 M5 176 1980 G A
CED80058 X.sub.4326 M5 179 1525 G A
CDZ96154 X.sub.4327 M5 179 1780 C T
CDZ96154 X.sub.4328 M5 179 2472 G A
CDZ96154 X.sub.4329 M5 179 2476 C T
CDZ96154 X.sub.4330 M5 188 815 C T
CED80060 X.sub.4331 M5 188 1174 C T
CED80060 X.sub.4332 M5 188 2163 G A
CED80060 X.sub.4333 M5 188 2170 G A
CED80060 X.sub.4334 M5 247 102 G A
CED80061 X.sub.4335 M5 247 989 C T
CED80061 X.sub.4336 M5 247 1053 G A
CED80061 X.sub.4337 M5 7 160 T C
X.sub.4338 M5 8 1110 C T
X.sub.4339 M5 11 154 A C
X.sub.4340 M5 11 158 C T
X.sub.4341 M5 15 28 C G
X.sub.4342 M5 24 513 T C
CDZ96160 X.sub.4343 M3 24 520 C G
CDZ96160 X.sub.4344 M5 24 5850 C T
CDZ96160 X.sub.4345 M5 24 29899 C T
CDZ96169 X.sub.4346 M5 24 169574 C T
CDZ96213 X.sub.4347 M5 24 172698 G A
CDZ96215 X.sub.4348 M5 24 180340 G A
CDZ96216 X.sub.4349 M5 24 266697 G A
CDZ96242 X.sub.4350 M5 24 307114 G A
CDZ96255 X.sub.4351 M5 24 334227 T A
CDZ96263 X.sub.4352 M5 24 335171 C T
CDZ96265 X.sub.4353 M5 24 340663 T C
CDZ96265 X.sub.4354 M5 24 400418 C T
CDZ96287 X.sub.4355 M5 24 420108 G A
CDZ96291 X.sub.4356 M5 27 445 C T
X.sub.4357 M5 27 1012 A C
X.sub.4358 M5 27 1013 T A
X.sub.4359 M5 32 158 C T
CDZ96332 X.sub.4360 M5 32 215 C T
CDZ96332 X.sub.4361 M5 32 2438 C T
CDZ96332 X.sub.4362 M5 32 2734 C T
CDZ96332 X.sub.4363 M5 32 2821 C T
CDZ96332 X.sub.4364 M5 32 3067 C T
CDZ96332 X.sub.4365 M5 32 3506 C T
CDZ96332 X.sub.4366 M5 32 3562 G A
CDZ96332 X.sub.4367 M5 33 399 T A
CED82002 X.sub.4368 M5 33 20227 G A
CED82006 X.sub.4369 M5 33 45488 C T
CED82012 X.sub.4370 M5 33 64676 G A
CED82019 X.sub.4371 M5 33 79913 G A
CED82024 X.sub.4372 M5 33 105276 G A
CED82036 X.sub.4373 M5 33 109397 G A
CED82038 X.sub.4374 M5 33 129884 G A
CED82045 X.sub.4375 M5 33 198050 C T
CED82067 X.sub.4376 M5 33 205554 C T
CED82069 X.sub.4377 M5 33 223703 G A
CED82075 X.sub.4378 M5 33 236149 C T
CED82078 X.sub.4379 M5 33 257786 C T
CED82084 X.sub.4380 M5 33 260027 G A
CED82084 X.sub.4381 M5 33 274627 G A
CED82091 X.sub.4382 M5 33 283808 C T
CED82093 X.sub.4383 M5 33 304408 C T
CED82099 X.sub.4384 M5 33 317713 G A
CED82104 X.sub.4385 M5 33 326016 T C
CED82108 X.sub.4386 M5 33 327840 C T
CED82108 X.sub.4387 M5 33 341890 G A
CED82113 X.sub.4388 M5 33 371277 G A
CED82121- CED82122 X.sub.4389 M5 33 374131 A G
CED82121- CED82122 X.sub.4390 M5 33 374134 A G
CED82121- CED82122 X.sub.4391 M5 33 374137 A T
CED82121- CED82122 X.sub.4392 M5 33 374150 A G
CED82121- CED82122 X.sub.4393 M5 33 374340 A G
CED82121- CED82122 X.sub.4394 M5 33 375339 A G
CED82121- CED82122 X.sub.4395 M5 33 375366 T C
CED82121- CED82122 X.sub.4396 M5 33 382577 C T
CED82122 X.sub.4397 M5 33 383212 G A
CED82122 X.sub.4398 M5 33 383308 C T
CED82122 X.sub.4399 M5 33 385319 A C
CED82122 X.sub.4400 M5 33 412908 A G
CED82131 X.sub.4401 M5 33 428329 G A
CED82136 X.sub.4402 M5 33 448815 G A
CED82144 X.sub.4403 M5 33 453975 C T
CED82147 X.sub.4404 M5 33 455451 C T
CED82146 X.sub.4405 M5 33 505339 C T
CED82165 X.sub.4406 M5 33 509127 C T
CED82166 X.sub.4407 M5 33 570390 G A
CED82188 X.sub.4408 M5 33 626521 C T
CED82203 X.sub.4409 M5 33 639242 G A
CED82208 X.sub.4410 M5 33 643436 G A
CED82208 X.sub.4411 M5 33 693516 C T
CED82225 X.sub.4412 M5 33 699423 C T
CED82227 X.sub.4413 M5 33 729705 C T
CED82234 X.sub.4414 M5 33 794549 C T
CED82254 X.sub.4415 M5 33 800536 G A
CED82259 X.sub.4416 M5 33 829825 C T
CED82271 X.sub.4417 M5 33 850373 G A
CED82278 X.sub.4418 M5 33 911146 G C
CED82293 X.sub.4419 M5 33 917545 A G
CED82294 X.sub.4420 M5 33 917558 G A
CED82294 X.sub.4421 M5 33 917586 T A
CED82294 X.sub.4422 M5 33 917771 A T
CED82294 X.sub.4423 M5 33 936350 T A
CED82300 X.sub.4424 M5 33 936571 A G
CED82300 X.sub.4425 M5 33 936600 G A
CED82300 X.sub.4426 M5 33 995886 G A
CED82318 X.sub.4427 M5 33 1038506 C T
CED82330 X.sub.4428 M5 33 1049699 G A
CED82334 X.sub.4429 M5 33 1138444 C T
CED82363 X.sub.4430 M5 33 1165914 G A
CED82372 X.sub.4431 M5 33 1169025 C T
CED82372 X.sub.4432 M5 33 1169999 G A
CED82372 X.sub.4433 M5 33 1183030 T C
CED82377 X.sub.4434 M5 33 1190451 G A
CED82378 X.sub.4435 M5 33 1191727 C T
CED82379 X.sub.4436 M5 33 1246468 C T
CED82392 X.sub.4437 M5 33 1248614 C T
CED82393 X.sub.4438 M5 33 1311181 G A
CED82413 X.sub.4439 M5 33 1316789 C T
CED82415 X.sub.4440 M5 33 1324395 G A
CED82417 X.sub.4441 M5 33 1333932 G A
CED82421 X.sub.4442 M5 33 1339376 C T
CED82424 X.sub.4443 M5 33 1396438 C T
CED82442 X.sub.4444 M5 33 1406738 G A
CED82444 X.sub.4445 M5 33 1411059 C T
CED82446 X.sub.4446 M5 33 1499347 G A
CED82472 X.sub.4447 M5 33 1502644 G A
CED82474 X.sub.4448 M5 33 1515148 G A
CED82478 X.sub.4449 M5 33 1515369 G A
CED82478 X.sub.4450 M5 33 1535309 C A
CED82484 X.sub.4451 M5 33 1535314 T G
CED82484 X.sub.4452 M5 33 1535316 G C
CED82484 X.sub.4453 M5 33 1535434 A T
CED82483 X.sub.4454 M5 33 1537493 C A
CED82485 X.sub.4455 M5 33 1537824 C T
CED82483 X.sub.4456 M5 33 1537835 G A
CED82483 X.sub.4457 M5 33 1544767 A C
CED82485- CED82486 X.sub.4458 M5 33 1544951 C G
CED82485- CED82486 X.sub.4459 M5 33 1572498 C T
CED82491 X.sub.4460 M5 33 1587443 C T
CED82497 X.sub.4461 M5 33 1596242 C T
CED82498 X.sub.4462 M5 33 1628812 C T
CED82510 X.sub.4463 M5 33 1638726 G A
CED82513 X.sub.4464 M5 33 1642659 G A
CED82515 X.sub.4465 M5 33 1666039 G A
CED82521 X.sub.4466 M5 33 1682149 C T
CED82526 X.sub.4467 M5 33 1689192 C T
CED82529 X.sub.4468 M5 33 1700000 G A
CED82534 X.sub.4469 M5 33 1714108 G A
CED82537 X.sub.4470 M5 33 1723348 C T
CED82539 X.sub.4471 M5 33 1767636 C T
CED82552 X.sub.4472 M5 33 1823362 C T
CED82571 X.sub.4473 M5 33 1848935 C T
CED82579 X.sub.4474 M5 33 1860991 G A
CED82583 X.sub.4475 M5 33 1861675 C T
CED82583 X.sub.4476 M5 33 1881896 T C
CED82588 X.sub.4477 M5 33 1887401 C T
CED82591 X.sub.4478 M5 33 1888706 C T
CED82592 X.sub.4479 M5 33 1938614 G A
CED82612 X.sub.4480 M5 33 1959142 G A
CED82619 X.sub.4481 M5 33 1975079 G A
CED82625 X.sub.4482 M5 33 2010230 C T
CED82636 X.sub.4483 M5 33 2014235 C T
CED82637 X.sub.4484 M5 33 2044014 G A
CED82647 X.sub.4485 M5 33 2046185 C T
CED82650 X.sub.4486 M5 33 2050847 G A
CED82651 X.sub.4487 M5 36 320 G A
X.sub.4488 M5 36 1056 G A
X.sub.4489 M5 36 1295 C T
X.sub.4490 M5 36 1461 A T
X.sub.4491 M5 42 804 C T
CDZ96333 X.sub.4492 M5 42 1559 G A
CDZ96333 X.sub.4493 M5 45 289 G A
X.sub.4494 M5 48 405 G A
X.sub.4495 M5 48 563 C T
X.sub.4496 M5 48 565 T C
X.sub.4497 M5 48 576 G A
X.sub.4498 M5 48 580 T A
X.sub.4499 M5 48 720 A G
X.sub.4500 M5 50 145 G A
X.sub.4501 M5 52 3470 G C
CED82664 X.sub.4502 M5 52 6285 C T
CED82665 X.sub.4503 M5 52 63859 C T
CED82686 X.sub.4504 M5 52 144382 C T
CED82709 X.sub.4505 M5 52 150382 C T
CED82712 X.sub.4506 M5 52 151974 C T
CED82712 X.sub.4507 M5 52 183986 C T
CED82722 X.sub.4508 M5 52 203253 A G
CED82730 X.sub.4509 M5 52 207354 C T
CED82730 X.sub.4510 M5 52 240075 G C
CED82734 X.sub.4511 M5 52 241012 A G
CED82734 X.sub.4512 M5 52 284733 G A
CED82747 X.sub.4513 M5 52 390095 G A
CED82784 X.sub.4514 M5 52 395374 G A
CED82786 X.sub.4515 M5 52 398723 C T
CED82786 X.sub.4516 M5 52 398728 C T
CED82786 X.sub.4517 M5 52 487472 C T
CED82814 X.sub.4518 M5 52 516267 C T
CED82823 X.sub.4519 M5 52 552099 G A
CED82837 X.sub.4520 M5 52 552173 G A
CED82837 X.sub.4521 M5 52 631479 C T
CED82860 X.sub.4522 M5 52 638622 G A
CED82862 X.sub.4523 M5 52 692048 C T
CED82884 X.sub.4524 M5 52 700204 G A
CED82888 X.sub.4525 M5 52 783981 C T
CED82919 X.sub.4526 M5 52 809156 C T
CED82928 X.sub.4527 M5 52 817452 T A
CED82928 X.sub.4528 M5 52 840755 C T
CED82935 X.sub.4529 M5 52 842352 C T
CED82934 X.sub.4530 M5 52 849671 G A
CED82940 X.sub.4531 M5 52 861376 C T
CED82946 X.sub.4532 M5 52 938650 G A
CED82973 X.sub.4533 M5 52 967316 A T
CED82984 X.sub.4534 M5 52 967701 T A
CED82983 X.sub.4535 M5 52 978727 C T
CED82988 X.sub.4536 M5 52 1003899 G A
CED83001 X.sub.4537 M5 52 1021202 C T
CED83005 X.sub.4538 M5 52 1029498 G A
CED83007 X.sub.4539 M5 52 1043011 C T
CED83012 X.sub.4540 M5 52 1067895 C T
CED83020 X.sub.4541 M5 52 1151398 G A
CED83046 X.sub.4542 M5 52 1158103 C T
CED83051 X.sub.4543 M5 52 1214927 C T
CED83068 X.sub.4544 M5 52 1219894 C T
CED83071 X.sub.4545 M5 52 1255291 G A
CED83086 X.sub.4546 M5 52 1350463 C T
CED83118 X.sub.4547 M5 52 1358630 C T
CED83119 X.sub.4548 M5 52 1363357 G A
CED83122 X.sub.4549 M5 52 1363405 C T
CED83123 X.sub.4550 M5 52 1365822 C T
CED83124 X.sub.4551 M5 52 1389320 G A
CED83130 X.sub.4552 M5 52 1399439 G A
CED83134 X.sub.4553 M5 52 1409725 G A
CED83139 X.sub.4554 M5 52 1458571 C T
CED83158 X.sub.4555 M5 52 1465985 G A
CED83159 X.sub.4556 M5 52 1474315 G A
CED83164 X.sub.4557 M5 52 1474412 G A
CED83166 X.sub.4558 M5 52 1526796 G A
CED83181 X.sub.4559 M5 52 1540879 C T
CED83186 X.sub.4560 M5 52 1546812 G A
CED83188 X.sub.4561 M5 52 1570053 C T
CED83200 X.sub.4562 M5 52 1583655 C T
CED83206 X.sub.4563 M5 52 1621166 C T
CED83219 X.sub.4564 M5 52 1665003 A G
CED83235 X.sub.4565 M5 52 1688685 C T
CED83243 X.sub.4566 M5 52 1708900 A G
CED83249 X.sub.4567 M5 52 1716210 C T
CED83250 X.sub.4568 M5 52 1765533 G A
CED83268 X.sub.4569 M5 52 1793370 G A
CED83275 X.sub.4570 M5 52 1796780 G A
CED83279 X.sub.4571 M5 52 1807309 G A
CED83283 X.sub.4572 M5 52 1871310 C T
CED83304 X.sub.4573 M5 52 1874150 G T
CED83305 X.sub.4574 M5 52 1893352 G A
CED83313 X.sub.4575 M5 52 1915927 G A
CED83315 X.sub.4576 M5 52 1938393 C T
CED83322 X.sub.4577 M5 52 1969873 C T
CED83333 X.sub.4578 M5 52 1987096 G A
CED83341 X.sub.4579 M5 52 1995167 G A
CED83342 X.sub.4580 M5 52 2029893 G A
CED83351 X.sub.4581 M5 52 2041781 C T
CED83355 X.sub.4582 M5 52 2048018 G A
CED83358 X.sub.4583 M5 52 2050245 G A
CED83359 X.sub.4584 M5 52 2071127 C T
CED83365 X.sub.4585 M5 52 2081390 G A
CED83367 X.sub.4586 M5 52 2093148 C T
CED83368 X.sub.4587 M5 52 2093251 C T
CED83368 X.sub.4588 M5 52 2102269 C T
CED83371 X.sub.4589 M5 52 2120665 C T
CED83376 X.sub.4590 M5 52 2136885 A G
CED83382 X.sub.4591 M5 52 2162878 G A
CED83392 X.sub.4592 M5 52 2211680 G A
CED83407 X.sub.4593 M5 52 2229000 G A
CED83410 X.sub.4594 M5 52 2248910 G A
CED83417 X.sub.4595 M5 52 2258192 C T
CED83422 X.sub.4596 M5 52 2265219 C T
CED83425 X.sub.4597 M5 52 2266378 C T
CED83423 X.sub.4598 M5 52 2296638 G A
CED83432 X.sub.4599 M5 52 2327266 C T
CED83445 X.sub.4600 M5 52 2364315 G A
CED83455 X.sub.4601 M5 52 2373120 C T
CED83456 X.sub.4602 M5 52 2400778 C T
CED83463 X.sub.4603 M5 52 2415283 C T
CED83469 X.sub.4604 M5 52 2421337 G A
CED83471 X.sub.4605 M5 52 2482102 G A
CED83491 X.sub.4606 M5 52 2543220 C T
CED83509 X.sub.4607 M5 53 26291 G A
CDZ96348 X.sub.4608 M5 53 55702 C T
CDZ96359 X.sub.4609 M5 54 4815 G A
CDZ96384 X.sub.4610 M5 54 4816 A T
CDZ96384 X.sub.4611 M5 54 4817 G C
CDZ96384 X.sub.4612 M5 54 4821 G A
CDZ96384 X.sub.4613 M5 54 16963 C T
CDZ96386 X.sub.4614 M5 54 83852 G A
CDZ96409 X.sub.4615 M5 54 93810 G A
CDZ96414 X.sub.4616 M5 54 106086 G A
CDZ96416 X.sub.4617 M5 54 194230 G A
CDZ96446 X.sub.4618 M5 54 202467 C T
CDZ96448 X.sub.4619 M5 54 206494 G A
CDZ96450 X.sub.4620 M5 54 207737 C T
CDZ96450 X.sub.4621 M5 54 245840 G A
CDZ96464 X.sub.4622 M5 54 274617 A T
CDZ96471 X.sub.4623 M5 54 278479 C T
CDZ96474 X.sub.4624 M5 54 290948 C T
CDZ96479 X.sub.4625 M5 54 317033 C A
CDZ96487 X.sub.4626 M5 54 354688 C T
CDZ96493 X.sub.4627 M5 54 357141 G A
CDZ96496 X.sub.4628 M5 54 370320 G A
CDZ96499 X.sub.4629 M5 54 383172 C T
CDZ96506 X.sub.4630 M5 54 391223 A G
CDZ96509 X.sub.4631 M5 54 402099 G A
CDZ96511 X.sub.4632 M5 54 413765 G A
CDZ96516 X.sub.4633 M5 54 427542 C T
CDZ96520 X.sub.4634 M5 54 431851 C T
CDZ96520 X.sub.4635 M5 54 437080 G A
CDZ96522 X.sub.4636 M5 54 478527 C T
CDZ96537 X.sub.4637 M5 54 555986 G A
CDZ96563 X.sub.4638 M5 54 564688 C T
CDZ96566 X.sub.4639 M5 54 616268 A G
CDZ96581 X.sub.4640 M5 54 619019 G A
CDZ96580 X.sub.4641 M5 54 648472 G A
CDZ96590 X.sub.4642 M5 54 709210 G A
CDZ96613 X.sub.4643 M5 54 733193 T C
CDZ96619 X.sub.4644 M5 54 743396 G A
CDZ96621 X.sub.4645 M5 58 93 T C
X.sub.4646 M5 64 2756 A C
CDZ96626 X.sub.4647 M5 64 2767 G A
CDZ96626 X.sub.4648 M5 64 2770 C T
CDZ96626 X.sub.4649 M5 64 2783 C T
CDZ96626 X.sub.4650 M5 67 111 G A
X.sub.4651 M5 69 20845 C T
CED83532 X.sub.4652 M5 69 29006 G A
CED83534 X.sub.4653 M5 69 48869 G A
CED83542 X.sub.4654 M5 69 52428 G A
CED83541 X.sub.4655 M5 69 82710 G A
CED83554 X.sub.4656 M5 69 84820 G A
CED83555 X.sub.4657 M5 69 97985 G A
CED83559 X.sub.4658 M5 69 107920 C T
CED83561 X.sub.4659 M5 69 173697 G A
CED83585 X.sub.4660 M5 69 179873 C T
CED83585 X.sub.4661 M5 69 201005 G A
CED83595 X.sub.4662 M5 69 201292 G A
CED83595 X.sub.4663 M5 69 293602 G A
CED83626 X.sub.4664 M5 69 305997 C T
CED83631 X.sub.4665 M5 69 384418 G A
CED83656 X.sub.4666 M5 69 415659 C T
CED83665 X.sub.4667 M5 69 461021 C T
CED83680 X.sub.4668 M5 69 461986 G A
CED83680 X.sub.4669 M5 69 467686 C T
CED83681 X.sub.4670 M5 69 566212 G A
CED83713 X.sub.4671 M5 69 585845 G A
CED83722 X.sub.4672 M5 69 599390 G A
CED83728 X.sub.4673 M5 69 631511 G A
CED83742 X.sub.4674 M5 69 637299 T C
CED83744 X.sub.4675 M5 69 675579 G A
CED83760 X.sub.4676 M5 69 676581 G A
CED83760 X.sub.4677 M5 69 676853 G A
CED83759 X.sub.4678 M5 69 678406 C T
CED83759 X.sub.4679 M5 69 682770 C T
CED83763 X.sub.4680 M5 69 703602 C T
CED83770 X.sub.4681 M5 69 741255 C T
CED83781 X.sub.4682 M5 69 781048 C T
CED83793 X.sub.4683 M5 69 865820 C T
CED83814 X.sub.4684 M5 69 869706 G A
CED83815 X.sub.4685 M5 69 872470 G A
CED83815 X.sub.4686 M5 69 892199 G A
CED83822 X.sub.4687 M5 69 894019 G A
CED83821 X.sub.4688 M5 69 894462 C T
CED83821 X.sub.4689 M5 69 898044 C T
CED83823 X.sub.4690 M3 69 949982 C T
CED83842 X.sub.4691 M5 69 971219 C T
CED83847 X.sub.4692 M5 69 988364 G A
CED83857 X.sub.4693 M5 69 1001408 G A
CED83859 X.sub.4594 M5 69 1021196 G A
CED83867 X.sub.4695 M5 69 1084824 G A
CED83891 X.sub.4696 M5 69 1084835 C T
CED83891 X.sub.4697 M5 69 1084848 A G
CED83891 X.sub.4698 M5 69 1084866 A G
CED83891 X.sub.4699 M5 69 1084931 C T
CED83891 X.sub.4700 M5 69 1102164 C T
CED83897 X.sub.4701 M5 69 1105560 C T
CED83899 X.sub.4702 M5 69 1109785 C T
CED83899 X.sub.4703 M5 69 1109813 A G
CED83899 X.sub.4704 M5 69 1109818 A G
CED83899 X.sub.4705 M5 69 1109819 T A
CED83899 X.sub.4706 M5 69 1109823 T C
CED83899 X.sub.4707 M5 69 1109830 A G
CED83899 X.sub.4708 M5 69 1109831 C A
CED83899 X.sub.4709 M5 69 1109835 A G
CED83899 X.sub.4710 M5 69 1153118 G A
CED83915 X.sub.4711 M5 69 1161041 A G
CED83918 X.sub.4712 M5 69 1179032 G A
CED83923 X.sub.4713 M5 69 1215253 G A
CED83936 X.sub.4714 M5 69 1218409 G A
CED83936 X.sub.4715 M5 69 1260087 G A
CED83949 X.sub.4716 M5 69 1342909 G A
CED83975 X.sub.4717 M5 69 1372486 C T
CED83987 X.sub.4718 M5 69 1396045 G A
CED83994 X.sub.4719 M5 69 1400546 G A
CED83995 X.sub.4720 M5 69 1411237 C T
CED84001 X.sub.4721 M5 69 1411421 C T
CED83999 X.sub.4722 M5 69 1492842 C T
CED84026 X.sub.4723 M5 69 1539964 C T
CED84041 X.sub.4724 M5 69 1568637 G A
CED84053 X.sub.4725 M5 69 1590302 G A
CED84059 X.sub.4726 M5 69 1652288 C T
CED84077 X.sub.4727 M5 69 1674261 C T
CED84084 X.sub.4728 M5 69 1687394 G A
CED84087 X.sub.4729 M5 69 1688555 C T
CED84088 X.sub.4730 M5 69 1701017 G A
CED84094 X.sub.4731 M5 69 1714728 G A
CED84097 X.sub.4732 M5 69 1715549 G A
CED84101 X.sub.4733 M5 69 1720116 G A
CED84102 X.sub.4734 M5 69 1720246 C T
CED84101 X.sub.4735 M5 69 1741179 C T
CED84109 X.sub.4736 M5 69 1790823 C T
CED84125 X.sub.4737 M5 69 1792597 C T
CED84126 X.sub.4738 M5 69 1800584 G A
CED84129 X.sub.4739 M5 69 1803813 G A
CED84128 X.sub.4740 M5 69 1854739 G A
CED84145 X.sub.4741 M5 69 1924621 C T
CED84172 X.sub.4742 M5 69 1967529 C T
CED84189 X.sub.4743 M5 69 1968848 A G
CED84189 X.sub.4744 M5 69 1975946 G A
CED84193 X.sub.4745 M5 69 1978129 C G
CED84193 X.sub.4746 M5 69 2001469 C T
CED84197 X.sub.4747 M5 69 2151569 C T
CED84251 X.sub.4745 M5 69 2160207 C T
CED84255 X.sub.4749 M5 69 2226113 C T
CED84272 X.sub.4750 M5 69 2231926 G A
CED84274 X.sub.4751 M5 69 2240834 C T
CED84277 X.sub.4752 M5 69 2255001 G A
CED84282 X.sub.4753 M5 69 2260222 C T
CED84282 X.sub.4754 M5 69 2325544 C T
CED84307 X.sub.4755 M5 69 2438727 C T
CED84343 X.sub.4756 M5 69 2443210 T A
CED84345 X.sub.4757 M5 69 2483433 G A
CED84352 X.sub.4758 M5 70 22 T C
X.sub.4759 M5 72 93 T C
X.sub.4760 M5 72 584 G A
X.sub.4761 M5 72 856 C T
X.sub.4762 M5 72 1163 C T
X.sub.4763 M5 77 34978 G T
CDZ96642 X.sub.4764 M5 77 39842 G A
CDZ96646 X.sub.4765 M5 77 47151 C T
CDZ96648 X.sub.4766 M5 77 65419 G A
CDZ96655 X.sub.4767 M5 77 84022 G A
CDZ96659 X.sub.4768 M5 78 1865 C T
CED84359 X.sub.4769 M5 78 6333 G A
CED84360 X.sub.4770 M5 78 35200 G A
CED84371 X.sub.4771 M5 78 155757 C T
CED84404 X.sub.4772 M5 78 238854 C T
CED84430 X.sub.4773 M5 78 262683 G A
CED84438 X.sub.4774 M5 78 263828 T C
CED84438 X.sub.4775 M5 78 276239 T A
CED84440 X.sub.4776 M5 78 276361 T C
CED84440 X.sub.4777 M5 78 276362 C T
CED84440 X.sub.4778 M5 78 281454 C A
CED84441 X.sub.4779 M5 78 298141 C G
CED84443 X.sub.4780 M5 78 299644 G A
CED84443 X.sub.4781 M5 78 301815 T C
CED84443 X.sub.4782 M5 78 302700 A G
CED84443 X.sub.4783 M5 78 333312 A G
CED84452 X.sub.4784 M5 78 368561 G A
CED84462 X.sub.4785 M5 78 386356 C T
CED84472 X.sub.4786 M5 78 404988 G A
CED84475 X.sub.4787 M5 78 415432 G A
CED84479 X.sub.4788 M5 78 440606 C T
CED84487 X.sub.4789 M5 78 444292 C T
CED84490 X.sub.4790 M5 78 480848 C T
CED84500 X.sub.4791 M5 78 506703 G A
CED84508 X.sub.4792 M5 78 611362 C T
CED84546 X.sub.4793 M5 78 666005 C T
CED84562 X.sub.4794 M5 78 708376 C T
CED84580 X.sub.4795 M5 78 763771 G A
CED84600 X.sub.4796 M5 78 774252 G A
CED84602 X.sub.4797 M5 78 811274 G A
CED84614 X.sub.4798 M5 78 895505 C T
CED84642 X.sub.4799 M5 78 904287 G A
CED84646 X.sub.4800 M5 78 952815 G A
CED84662 X.sub.4801 M5 78 952860 G A
CED84662 X.sub.4802 M5 78 988551 G A
CED84675 X.sub.4803 M5 78 1023381 G A
CED84688 X.sub.4804 M5 78 1108918 C T
CED84721 X.sub.4805 M5 78 1115511 G A
CED84723 X.sub.4806 M5 78 1216573 C T
CED84752 X.sub.4807 M5 78 1247678 C T
CED84761 X.sub.4808 M5 78 1266077 G A
CED84770 X.sub.4809 M5 78 1302286 C T
CED84782 X.sub.4810 M5 78 1316520 T C
CED84788 X.sub.4811 M5 78 1317124 G A
CED84787 X.sub.4812 M5 78 1344640 C T
CED84795 X.sub.4813 M5 78 1360288 G A
CED84802 X.sub.4814 M5 78 1406981 C T
CED84821 X.sub.4815 M5 78 1410781 G A
CED84825 X.sub.4816 M5 78 1426722 C T
CED84829 X.sub.4817 M5 78 1475803 G A
CED84845 X.sub.4818 M5 78 1495995 C T
CED84852 X.sub.4819 M5 78 1498179 G A
CED84852 X.sub.4820 M5 78 1568326 C T
CED84868 X.sub.4821 M5 78 1607916 C T
CED84878 X.sub.4822 M5 78 1642170 G A
CED84889 X.sub.4823 M5 78 1660408 G A
CED84897 X.sub.4824 M5 78 1694684 C T
CED84912 X.sub.4825 M5 78 1742796 G A
CED84926 X.sub.4826 M5 79 65 G A
CDZ96674 X.sub.4827 M5 79 3779 G A
CDZ96674 X.sub.4828 M5 79 41271 C T
CDZ96684 X.sub.4829 M5 79 47085 G A
CDZ96684 X.sub.4830 M5 79 57804 G A
CDZ96687 X.sub.4831 M5 79 71637 C T
CDZ96691 X.sub.4832 M5 79 132683 C T
CDZ96713 X.sub.4833 M5 79 171814 C T
CDZ96727 X.sub.4834 M5 79 241350 C T
CDZ96753 X.sub.4835 M5 79 281783 C T
CDZ96768 X.sub.4836 M5 79 307021 C T
CDZ96777 X.sub.4837 M5 79 324145 C T
CDZ96781 X.sub.4838 M5 79 346823 G A
CDZ96789 X.sub.4839 M5 79 368176 G A
CDZ96795 X.sub.4840 M5 79 369258 G A
CDZ96793 X.sub.4841 M5 79 489676 G A
CDZ96839 X.sub.4842 M5 79 492523 C T
CDZ96842 X.sub.4843 M5 79 575411 C T
CDZ96868 X.sub.4844 M5 79 579674 G A
CDZ96871 X.sub.4845 M5 79 604739 G A
CDZ96879 X.sub.4846 M5 79 611702 C T
CDZ96881 X.sub.4847 M5 79 617057 C T
CDZ96882 X.sub.4848 M5 79 679140 C T
CDZ96904 X.sub.4849 M5 79 691309 C T
CDZ96911 X.sub.4850 M5 79 696174 G A
CDZ96911 X.sub.4851 M5 79 735053 T C
CDZ96928 X.sub.4852 M5 79 747717 A G
CDZ96929 X.sub.4853 M5 79 749595 A C
CDZ96930 X.sub.4854 M5 79 759403 C T
CDZ96931 X.sub.4855 M5 79 759513 G A
CDZ96931 X.sub.4856 M5 79 759589 G A
CDZ96932 X.sub.4857 M5 79 759659 G A
CDZ96931 X.sub.4858 M5 79 760430 T C
CDZ96932 X.sub.4859 M5 79 760541 A G
CDZ96932 X.sub.4860 M5 79 760891 A G
CDZ96932 X.sub.4861 M5 79 760988 G T
CDZ96932 X.sub.4862 M5 79 761056 T C
CDZ96932 X.sub.4863 M5 79 768537 A G
CDZ96933 X.sub.4864 M5 79 771663 T G
CDZ96933 X.sub.4865 M5 79 776112 A G
CDZ96934 X.sub.4866 M5 79 780012 T C
CDZ96934 X.sub.4867 M5 79 786064 A G
CDZ96934 X.sub.4868 M5 79 798799 C T
CDZ96939 X.sub.4869 M5 79 827202 G A
CDZ96946 X.sub.4870 M5 79 907000 C T
CDZ96976 X.sub.4871 M5 79 914302 C T
CDZ96977 X.sub.4872 M5 79 928047 G A
CDZ96986 X.sub.4873 M5 79 933234 G A
CDZ96987 X.sub.4874 M5 79 959497 C T
CDZ96997 X.sub.4875 M5 79 1000786 A G
CDZ97007 X.sub.4876 M5 79 1045859 C T
CDZ97023 X.sub.4877 M5 79 1052968 C T
CDZ97024 X.sub.4878 M5 79 1081745 C T
CDZ97037 X.sub.4879 M5 79 1086267 G A
CDZ97038 X.sub.4880 M5 79 1117040 C T
CDZ97047 X.sub.4881 M5 79 1123288 C T
CDZ97049 X.sub.4882 M5 79 1140763 G A
CDZ97053 X.sub.4883 M5 79 1209208 G A
CDZ97077 X.sub.4884 M5 79 1229129 G A
CDZ97086 X.sub.4885 M5 79 1231740 C T
CDZ97087 X.sub.4886 M5 79 1254757 G A
CDZ97095 X.sub.4887 M5 79 1284476 C T
CDZ97106 X.sub.4888 M5 79 1318034 C T
CDZ97117 X.sub.4889 M5 79 1336766 C T
CDZ97121 X.sub.4890 M5 79 1367232 C T
CDZ97129 X.sub.4891 M5 79 1394034 G A
CDZ97137 X.sub.4892 M5 79 1414969 G A
CDZ97147 X.sub.4893 M5 79 1430954 G A
CDZ97152 X.sub.4894 M5 79 1447480 G A
CDZ97156 X.sub.4895 M5 79 1517815 C T
CDZ97180 X.sub.4896 M5 79 1533781 C T
CDZ97185 X.sub.4897 M5 79 1540205 C T
CDZ97186 X.sub.4898 M5 79 1624415 G A
CDZ97217 X.sub.4899 M5 79 1633005 A T
CDZ97217 X.sub.4900 M5 79 1658469 C T
CDZ97227 X.sub.4901 M5 79 1674448 G A
CDZ97228 X.sub.4902 M5 79 1694516 C T
CDZ97233 X.sub.4903 M5 79 1696776 G A
CDZ97234 X.sub.4904 M5 79 1704321 G A
CDZ97235 X.sub.4905 M5 79 1797660 C T
CDZ97265 X.sub.4906 M5 79 1797676 G A
CDZ97265 X.sub.4907 M5 79 1809211 C T
CDZ97268 X.sub.4908 M5 79 1819746 C T
CDZ97273 X.sub.4909 M5 79 1842448 G A
CDZ97282 X.sub.4910 M5 79 1850295 G A
CDZ97285 X.sub.4911 M5 79 1854359 G A
CDZ97285 X.sub.4912 M5 79 1855037 A G
CDZ97285 X.sub.4913 M5 79 1859220 A G
CDZ97291 X.sub.4914 M5 79 1864111 C T
CDZ97291 X.sub.4915 M5 79 1912360 G A
CDZ97307 X.sub.4916 M5 79 1930688 G A
CDZ97315 X.sub.4917 M5 79 2013361 C T
CDZ97344 X.sub.4918 M5 79 2027861 C T
CDZ97350 X.sub.4919 M5 79 2089423 C T
CDZ97372 X.sub.4920 M5 79 2115870 G A
CDZ97380 X.sub.4921 M5 79 2116476 C T
CDZ97380 X.sub.4922 M5 79 2121041 G A
CDZ97380 X.sub.4923 M5 79 2152573 C T
CDZ97392 X.sub.4924 M5 79 2159433 G T
CDZ97394 X.sub.4925 M5 79 2188410 G A
CDZ97405 X.sub.4926 M5 79 2268540 C T
CDZ97435 X.sub.4927 M5 79 2271463 G A
CDZ97437 X.sub.4928 M5 79 2294761 G A
CDZ97444 X.sub.4929 M5 79 2315869 A C
CDZ97452 X.sub.4930 M5 79 2317043 G A
CDZ97452 X.sub.4931 M5 79 2323713 C T
CDZ97455 X.sub.4932 M5 79 2339881 C G
CDZ97460 X.sub.4933 M5 79 2340326 G A
CDZ97462 X.sub.4934 M5 79 2340636 T C
CDZ97462 X.sub.4935 M5 85 462 G A
X.sub.4936 M5 85 463 A G
X.sub.4937 M5 85 467 A T
X.sub.4938 M5 85 512 A G
X.sub.4939 M5 85 516 G A
X.sub.4940 M5 85 521 C T
X.sub.4941 M5 85 522 A G
X.sub.4942 M5 86 230 A G
X.sub.4943 M5 88 119 C T
CDZ97464 X.sub.4944 M5 88 196 G A
CDZ97464 X.sub.4945 M5 88 898 C A
CDZ97464 X.sub.4946 M5 93 1037 A C
X.sub.4947 M5 99 245 G A
X.sub.4948 M5 103 768 C T
X.sub.4949 M5 105 258 A G
CDZ97474 X.sub.4950 M5 109 396 T C
X.sub.4951 M5 118 396 C T
CDZ97478 X.sub.4952 M5 118 870 G A
CDZ97478 X.sub.4953 M5 118 1491 G A
CDZ97478 X.sub.4954 M5 124 45141 G A
CDZ97491 X.sub.4955 M5 124 72117 G A
CDZ97501 X.sub.4956 M5 124 72760 G A
CDZ97501 X.sub.4957 M5 124 94611 G A
CDZ97507 X.sub.4958 M5 124 111749 G A
CDZ97512 X.sub.4959 M5 124 156052 G A
CDZ97524 X.sub.4960 M5 124 207992 C T
CDZ97541 X.sub.4961 M5 124 222249 C T
CDZ97547 X.sub.4962 M5 124 253872 C T
CDZ97553 X.sub.4963 M5 125 9173 C T
CDZ97563 X.sub.4964 M5 125 35864 T C
CDZ97573 X.sub.4965 M5 129 299 G A
CDZ97577 X.sub.4966 M5 129 433 G A
CDZ97577 X.sub.4967 M5 129 856 G A
CDZ97577 X.sub.4968 M5 129 1013 C T
CDZ97577 X.sub.4969 M5 130 674 C T
CDZ97578 X.sub.4970 M5 138 123 G T
X.sub.4971 M5 141 10162 G A
CDZ97582 X.sub.4972 M5 141 15764 C T
CDZ97587 X.sub.4973 M5 149 2074 T G
CDZ97598 X.sub.4974 M5 149 2453 C T
CDZ97598 X.sub.4975 M5 159 106 A C
X.sub.4976 M5 162 70025 C T
CDZ97625 X.sub.4977 M5 162 70405 A G
CDZ97625 X.sub.4978 M5 162 93443 G A
CDZ97631 X.sub.4979 M5 162 96194 G A
CDZ97631 X.sub.4980 M5 162 117736 G A
CDZ97639 X.sub.4981 M5 162 199495 G A
CDZ97664 X.sub.4982 M5 162 214099 G A
CDZ97671 X.sub.4983 M5 162 218351 G A
CDZ97671 X.sub.4984 M5 162 223407 C T
CDZ97674 X.sub.4985 M5 162 308369 T C
CDZ97702 X.sub.4986 M5 162 311666 A G
CDZ97702 X.sub.4987 M5 162 311707 C G
CDZ97702 X.sub.4988 M5 162 321070 C T
CDZ97703 X.sub.4989 M5 162 321073 A G
CDZ97703 X.sub.4990 M5 162 321460 C G
CDZ97703 X.sub.4991 M5 162 321463 A C
CDZ97703 X.sub.4992 M5 162 322591 G A
CDZ97703 X.sub.4993 M5 162 323448 T G
CDZ97703 X.sub.4994 M5 162 323735 A G
CDZ97703 X.sub.4995 M5 162 324114 T C
CDZ97703 X.sub.4996 M5 162 324139 C T
CDZ97703 X.sub.4997 M5 162 324568 A G
CDZ97703 X.sub.4998 M5 162 360320 G A
CDZ97714 X.sub.4999 M5 162 398165 C T
CDZ97730 X.sub.5000 M5 162 423180 C T
CDZ97740 X.sub.5001 M5 162 424391 C T
CDZ97740 X.sub.5002 M5 162 444123 T C
CDZ97748 X.sub.5003 M5 162 467207 C T
CDZ97755 X.sub.5004 M5 162 480722 G A
CDZ97761 X.sub.5005 M5 162 487433 G A
CDZ97763 X.sub.5006 M5 162 491906 G A
CDZ97764 X.sub.5007 M5 162 492101 G A
CDZ97764 X.sub.5008 M5 162 501886 C T
CDZ97769 X.sub.5009 M5 162 631700 G A
CDZ97811 X.sub.5010 M5 162 632311 G A
CDZ97814 X.sub.5011 M5 162 633321 G A
CDZ97814 X.sub.5012 M5 162 633633 G A
CDZ97814 X.sub.5013 M5 162 640005 C T
CDZ97815 X.sub.5014 M5 162 721840 G A
CDZ97838 X.sub.5015 M5 162 738675 G A
CDZ97842 X.sub.5016 M5 162 738686 C T
CDZ97842 X.sub.5017 M5 162 808830 G A
CDZ97869 X.sub.5018 M5 162 825209 G A
CDZ97877 X.sub.5019 M5 162 871911 C T
CDZ97890 X.sub.5020 M5 162 914850 C T
CDZ97904 X.sub.5021 M5 162 952036 T A
CDZ97918 X.sub.5022 M5 185 21 C T
CDZ97957 X.sub.5023 M5 189 96257 C T
CDZ97987 X.sub.5024 M5 189 126573 G A
CDZ97996 X.sub.5025 M5 189 127356 G A
CDZ97996 X.sub.5026 M5 189 149091 G A
CDZ98004 X.sub.5027 M5 189 194647 A G
CDZ98020 X.sub.5028 M5 189 194665 A G
CDZ98020 X.sub.5029 M5 189 298487 C T
CDZ98056 X.sub.5030 M5 189 323680 C T
CDZ98063 X.sub.5031 M5 189 371247 G A
CDZ98078 X.sub.5032 M5 189 452298 G A
CDZ98106 X.sub.5033 M5 191 342 A G
CDZ98107 X.sub.5034 M5 191 347 C T
CDZ98107 X.sub.5035 M5 191 427 C T
CDZ98107 X.sub.5036 M5 191 451 C T
CDZ98107 X.sub.5037 M5 191 487 A G
CDZ98107 X.sub.5038 M5 197 624 C T
CDZ98111 X.sub.5039 M5 198 202 C A
X.sub.5040 M5 198 203 G A
X.sub.5041 M5 198 238 C T
X.sub.5042 M5 198 265 C T
X.sub.5043 M5 199 688 C T
X.sub.5044 M5 199 911 C T
X.sub.5045 M5 199 971 C T
X.sub.5046 M5 199 1218 C T
X.sub.5047 M5 202 171 C T
X.sub.5048 M5 205 360 C T
CDZ98112 X.sub.5049 M5 205 981 C T
CDZ98112 X.sub.5050 M5 207 406 G A
X.sub.5051 M5 208 117 G A
X.sub.5052 M5 208 476 G A
X.sub.5053 M5 208 616 G A
X.sub.5054 M5 208 935 G A
X.sub.5055 M5 209 312 C T
CDZ98113 X.sub.5056 M5 214 197 C G
CDZ98116 X.sub.5057 M5 223 93 G A
CDZ98118 X.sub.5058 M5 223 102 A G
CDZ98118 X.sub.5059 M5 223 133 A G
CDZ98118 X.sub.5060 M5 223 150 T C
CDZ98118 X.sub.5061 M5 223 155 A C
CDZ98118 X.sub.5062 M5 223 158 T C
CDZ98118 X.sub.5063 M5 223 160 C T
CDZ98118 X.sub.5064 M5 223 175 G A
CDZ98118 X.sub.5065 M5 223 177 A G
CDZ98118 X.sub.5066 M5 223 291 C A
CDZ98118 X.sub.5067 M5 225 317 C T
X.sub.5068 M5 227 202 G A
X.sub.5069 M5 232 340 G A
CDZ98119 X.sub.5070 M5 232 1379 C T
CDZ98119 X.sub.5071 M5 232 1521 C T
CDZ98119 X.sub.5072 M5 232 1662 G A
CDZ98119 X.sub.5073 M5 232 1761 C T
CDZ98119 X.sub.5074 M5 232 2027 C T
CDZ98119 X.sub.5075 M5 232 3060 C T
CDZ98120 X.sub.5076 M5 232 3284 C T
CDZ98119 X.sub.5077 M5 232 4437 G A
CDZ98121 X.sub.5078 M5 232 4561 C T
CDZ98120 X.sub.5079 M5 242 7334 C T
CDZ98125 X.sub.5080 M5 242 41710 G A
CDZ98131 X.sub.5081 M5 242 50262 G A
CDZ98135 X.sub.5082 M5 242 88037 G A
CDZ98147 X.sub.5083 M5 242 107587 G A
CDZ98153 X.sub.5084 M5 242 168689 G A
CDZ98172 X.sub.5085 M5 242 194983 C T
CDZ98179 X.sub.5086 M5 242 213399 C T
CDZ98185 X.sub.5087 M5 242 213986 G A
CDZ98185 X.sub.5088 M5 242 227271 C T
CDZ98191 X.sub.5089 M5 242 233088 G A
CDZ98193 X.sub.5090 M5 242 233141 G A
CDZ98193 X.sub.5091 M5 242 310353 G A
CDZ98216 X.sub.5092 M5 242 363677 G A
CDZ98233 X.sub.5093 M5 242 376713 G A
CDZ98238 X.sub.5094 M5 242 379812 C T
CDZ98238 X.sub.5095 M5 242 404132 G A
CDZ98248 X.sub.5096 M5 242 405825 G A
CDZ98250 X.sub.5097 M5 242 412676 G A
CDZ98249 X.sub.5098 M5 242 432104 C T
CDZ98255 X.sub.5099 M5 242 485936 G A
CDZ98270 X.sub.5100 M5 242 492389 G A
CDZ98274 X.sub.5101 M5 242 514780 C T
CDZ98282 X.sub.5102 M5 242 542663 G A
CDZ98290 X.sub.5103 M5 242 559999 G A
CDZ98297 X.sub.5104 M5 242 602456 G A
CDZ98308 X.sub.5105 M5 242 602531 G A
CDZ98308 X.sub.5106 M5 242 604704 C T
CDZ98309 X.sub.5107 M5 246 329 C G
CDZ98328 X.sub.5108 M5 246 331 T C
CDZ98328 X.sub.5109 M5 249 206 G A
CED84929 X.sub.5110 M5 249 72016 C T
CED84950 X.sub.5111 M5 249 110060 C T
CED84968 X.sub.5112 M5 249 123789 C T
CED84972 X.sub.5113 M5 249 142920 G A
CED84978 X.sub.5114 M5 249 157550 C T
CED84983 X.sub.5115 M5 249 191304 C T
CED84988 X.sub.5116 M5 249 238318 C T
CED85003 X.sub.5117 M5 249 253494 C T
CED85008 X.sub.5118 M5 249 269707 G A
CED85013 X.sub.5119 M5 249 272075 C T
CED85013 X.sub.5120 M5 249 305975 G A
CED85023 X.sub.5121 M5 249 420458 C T
CED85069 X.sub.5122 M5 249 436175 G A
CED85073 X.sub.5123 M5 249 445429 G A
CED85075 X.sub.5124 M5 249 476060 A G
CED85088 X.sub.5125 M5 249 485782 C T
CED85089 X.sub.5126 M5 249 501310 C T
CED85093 X.sub.5127 M5 249 501510 T C
CED85093 X.sub.5128 M5 249 506067 A G
CED85094 X.sub.5129 M5 249 532943 A G
CED85099 X.sub.5130 M5 249 571922 C T
CED85115 X.sub.5131 M5 249 598579 C T
CED85125 X.sub.5132 M5 249 626627 G A
CED85132 X.sub.5133 M5 249 637944 G A
CED85135 X.sub.5134 M5 249 660408 G A
CED85144 X.sub.5135 M5 249 715551 G A
CED85163 X.sub.5136 M5 249 842136 C T
CED85198 X.sub.5137 M5 249 849958 C T
CED85201 X.sub.5138 M5 249 854220 G A
CED85201 X.sub.5139 M5 249 886063 G A
CED85208 X.sub.5140 M5 249 911274 C T
CED85218 X.sub.5141 M5 249 926107 C T
CED85222 X.sub.5142 M5 249 932606 C T
CED85223 X.sub.5143 M5 249 945434 C T
CED85227 X.sub.5144 M5 249 945727 C T
CED85227 X.sub.5145 M5 249 969333 G T
CED85238 X.sub.5146 M5 249 977170 C T
CED85242 X.sub.5147 M5 249 989520 C T
CED85243 X.sub.5148 M5 249 1014098 C T
CED85252 X.sub.5149 M5 249 1014926 C T
CED85252 X.sub.5150 M5 249 1063615 C T
CED85265 X.sub.5151 M5 249 1089152 G A
CED85274 X.sub.5152 M5 249 1144309 G A
CED85291 X.sub.5153 M5 249 1176977 G A
CED85303 X.sub.5154 M5 249 1195367 G A
CED85307 X.sub.5155 M5 249 1203953 G A
CED85311 X.sub.5156 M5 249 1209489 C T
CED85313 X.sub.5157 M5 249 1230068 C T
CED85319 X.sub.5158 M5 249 1234239 C T
CED85319 X.sub.5159 M5 249 1286733 G A
CED85336 X.sub.5160 M5 249 1299472 C T
CED85343 X.sub.5161 M5 249 1310059 C T
CED85346 X.sub.5162 M5 249 1331428 G A
CED85352 X.sub.5163 M5 249 1391343 G A
CED85372 X.sub.5164 M5 249 1393971 G A
CED85373 X.sub.5165 M5 249 1437896 G A
CED85389 X.sub.5166 M5 249 1437902 G A
CED85389 X.sub.5167 M5 249 1457529 G A
CED85398 X.sub.5168 M5 249 1471661 C T
CED85402 X.sub.5169 M5 249 1475590 G A
CED85404 X.sub.5170 M5 249 1498029 T C
CED85415 X.sub.5171 M5 249 1498823 T C
CED85414 X.sub.5172 M5 249 1498829 C T
CED85414 X.sub.5173 M5 249 1499741 G A
CED85415 X.sub.5174 M5 249 1502631 G T
CED85416 X.sub.5175 M5 249 1502641 T A
CED85416 X.sub.5176 M5 249 1502819 T G
CED85416 X.sub.5177 M5 249 1505634 T G
CED85416 X.sub.5178 M5 24 1518591 T A
CED85419 X.sub.5179 M5 249 1519431 A G
CED85419 X.sub.5180 M5 249 1520420 G C
CED85420 X.sub.5181 M5 249 1531574 C T
CED85423 X.sub.5182 M5 249 1599907 C T
CED85444 X.sub.5183 M5 249 1619036 G A
CED85450 X.sub.5184 M5 249 1636931 G A
CED85455 X.sub.5185 M5 249 1653615 T G
CED85457 X.sub.5186 M5 249 1653962 C T
CED85458 X.sub.5187 M5 249 1655479 C T
CED85458 X.sub.5188 M5 249 1666185 C T
CED85460 X.sub.5189 M5 249 1691139 G T
CED85467 X.sub.5190 M5 249 1726777 C T
CED85474 X.sub.5191 M5 249 1766819 C T
CED85490 X.sub.5192 M5 249 1780551 A G
CED85493 X.sub.5193 M5 249 1780569 A G
CED85493 X.sub.5194 M5 249 1801965 G A
CED85501 X.sub.5195 M5 249 1803575 C T
CED85502 X.sub.5196 M5 249 1823713 A G
CED85506 X.sub.5197 M5 249 1862072 C T
CED85520 X.sub.5198 M5 249 1880762 G A
CED85525 X.sub.5199 M5 249 1944026 G A
CED85545 X.sub.5200 M5 249 1951259 G A
CED85547 X.sub.5201 M5 249 1988505 C T
CED85560 X.sub.5202 M5 249 2015272 G A
CED85567 X.sub.5203 M5 249 2021262 G A
CED85569 X.sub.5204 M5 249 2027477 G A
CED85573 X.sub.5205 M5 249 2054064 C T
CED85583 X.sub.5206 M5 249 2110956 C T
CED85603 X.sub.5207 M5 249 2124517 C T
CED85607 X.sub.5208 M5 249 2167664 G A
CED85620 X.sub.5209 M5 249 2178506 G A
CED85622 X.sub.5210 M5 249 2183695 G A
CED85623 X.sub.5211 M5 249 2198205 G A
CED85628 X.sub.5212 M5 249 2223626 G A
CED85633 X.sub.5213 M5 249 2254072 G A
CED85640 X.sub.5214 M5 249 2255547 G C
CED85640 X.sub.5215 M5 252 512 C T
X.sub.5216 M5 252 524 C T
X.sub.5217 M5 258 576 A G
X.sub.5218 M5 258 676 T C
X.sub.5219 M5 258 1139 A T
X.sub.5220 M5 258 1394 G A
X.sub.5221 M5 260 156 G A
X.sub.5222 M5 262 4049 G A
CDZ98330 X.sub.5223 M5 262 30347 G A
CDZ98338 X.sub.5224 M5 262 30359 G A
CDZ98338 X.sub.5225 M5 262 63941 G A
CDZ98349 X.sub.5226 M5 262 134217 G A
CDZ98371 X.sub.5227 M5 262 139442 C T
CDZ98375 X.sub.5228 M5 262 144566 G A
CDZ98375 X.sub.5229 M5 262 148151 C T
CDZ98375 X.sub.5230 M5 262 148199 G A
CDZ98376 X.sub.5231 M5 262 164438 G A
CDZ98383 X.sub.5232 M5 262 201531 G A
CDZ98396 X.sub.5233 M5 262 252708 G A
CDZ98414 X.sub.5234 M5 262 286191 C T
CDZ98425 X.sub.5235 M5 262 319302 G A
CDZ98436 X.sub.5236 M5 262 350852 C T
CDZ98449 X.sub.5237 M5 262 351354 G A
CDZ98450 X.sub.5238 M5 262 366171 G A
CDZ98452 X.sub.5239 M5 262 380519 C T
CDZ98457 X.sub.5240 M5 262 397539 G A
CDZ98463 X.sub.5241 M5 262 414403 C T
CDZ98467 X.sub.5242 M5 262 415802 C T
CDZ98467 X.sub.5243 M5 262 420102 G A
CDZ98468 X.sub.5244 M5 262 446956 C T
CDZ98477 X.sub.5245 M5 262 457461 T A
CDZ98483 X.sub.5246 M5 262 510643 G A
CDZ98502 X.sub.5247 M5 262 539428 G A
CDZ98514 X.sub.5248 M5 262 539452 A G
CDZ98514 X.sub.5249 M5 262 539470 A G
CDZ98514 X.sub.5250 M5 262 552414 C T
CDZ98518 X.sub.5251 M5 262 557280 G A
CDZ98518 X.sub.5252 M5 262 560713 G A
CDZ98519 X.sub.5253 M5 262 562795 C T
CDZ98521 X.sub.5254 M5 262 567591 G A
CDZ98524 X.sub.5255 M5 262 567801 G A
CDZ98524 X.sub.5256 M5 262 607661 G A
CDZ98533 X.sub.5257 M5 262 618198 G A
CDZ98538 X.sub.5258 M5 262 638804 G C
CDZ98544 X.sub.5259 M5 262 639869 G C
CDZ98544 X.sub.5260 M5 262 639962 A G
CDZ98544 X.sub.5261 M5 262 653920 A G
CDZ98545 X.sub.5262 M5 262 655754 A T
CDZ98545 X.sub.5263 M5 262 655757 T C
CDZ98545 X.sub.5264 M5 262 656323 C G
CDZ98545 X.sub.5265 M5 262 668764 C T
CDZ98545 X.sub.5266 M5 262 673556 G A
CDZ98548 X.sub.5267 M5 262 691577 C T
CDZ98551 X.sub.5268 M5 262 733603 C T
CDZ98566 X.sub.5269 M5 262 751209 C T
CDZ98572 X.sub.5270 M5 262 801565 G A
CDZ98589 X.sub.5271 M5 262 822734 G A
CDZ98597 X.sub.5272 M5 262 825723 A G
CDZ98598 X.sub.5273 M5 262 831789 C T
CDZ98601 X.sub.5274 M5 262 835874 C T
CDZ98601 X.sub.5275 M5 262 865999 G A
CDZ98613 X.sub.5276 M5 262 923390 C T
CDZ98633 X.sub.5277 M5 262 971713 G A
CDZ98649 X.sub.5278 M5 262 976074 C T
CDZ98650 X.sub.5279 M5 262 978252 T C
CDZ98651 X.sub.5280 M5 262 1044256 G A
CDZ98669 X.sub.5281 M5 262 1209662 G A
CDZ98723 X.sub.5282 M5 262 1226072 C T
CDZ98730 X.sub.5283 M5 262 1277604 G A
CDZ98747 X.sub.5284 M5 262 1305361 G A
CDZ98753 X.sub.5285 M5 262 1329643 C T
CDZ98760 X.sub.5286 M5 262 1351116 A G
CDZ98766 X.sub.5287 M5 262 1415479 C T
CDZ98789 X.sub.5288 M5 262 1424293 G A
CDZ98791 X.sub.5289 M5 262 1455677 G A
CDZ98804 X.sub.5290 M5 262 1458863 C T
CDZ98807 X.sub.5291 M5 262 1549845 C T
CDZ98837 X.sub.5292 M5 262 1550311 C T
CDZ98836 X.sub.5293 M5 262 1550456 C T
CDZ98837 X.sub.5294 M5 262 1558074 G A
CDZ98840 X.sub.5295 M5 262 1592640 C T
CDZ98849 X.sub.5296 M5 262 1615762 G A
CDZ98855 X.sub.5297 M5 262 1677620 G A
CDZ98873 X.sub.5298 M5 262 1694625 C T
CDZ98878 X.sub.5299 M5 262 1695377 C T
CDZ98878 X.sub.5300 M5 262 1706076 G A
CDZ98885 X.sub.5301 M5 262 1709988 G A
CDZ98884 X.sub.5302 M5 262 1712334 G A
CDZ98886 X.sub.5303 M5 262 1716385 G A
CDZ98887 X.sub.5304 M5 266 252 C T
X.sub.5305 M5 267 93 G A
X.sub.5306 M5 267 94 A G
X.sub.5307 M5 267 133 T C
X.sub.5308 M5 267 134 C T
X.sub.5309 M6 22 1643 C T
CED80056 X.sub.5310 M6 22 2524 G A
CED80056 X.sub.5311 M6 28 236 G A
CDZ96150 X.sub.5312 M6 28 377 G A
CDZ96150 X.sub.5313 M6 28 1506 C T
CDZ96150 X.sub.5314 M6 28 1677 C T
CDZ96150 X.sub.5315 M6 43 464 G A
CDZ96151 X.sub.5316 M6 43 753 C T
CDZ96151 X.sub.5317 M6 4 757 G A
CDZ96151 X.sub.5318 M6 43 1527 C T
CDZ96151 X.sub.5319 M6 43 1748 G A
CDZ96151 X.sub.5320 M6 43 1928 C T
CDZ96151 X.sub.5321 M6 62 26 T A
CDZ96152 X.sub.5322 M6 62 27 T C
CDZ96152 X.sub.5323 M6 62 55 T A
CDZ96152 X.sub.5324 M6 62 403 C T
CDZ96152 X.sub.5325 M6 62 875 G A
CDZ96152 X.sub.5326 M6 102 339 C T
CDZ96153 X.sub.5327 M6 102 951 G A
CDZ96153 X.sub.5328 M6 102 1042 G A
CDZ96153 X.sub.5329 M6 102 2334 G A
CDZ96153 X.sub.5330 M6 102 2590 C T
CDZ96153 X.sub.5331 M6 102 3427 C T
CDZ96153 X.sub.5332 M6 176 358 G A
CED80058 X.sub.5333 M6 176 1872 G A
CED80058 X.sub.5334 M6 176 1980 G A
CED80058 X.sub.5335 M6 176 2335 A G
CED80058 X.sub.5336 M6 176 2349 G A
CED80058 X.sub.5337 M6 179 9 A G
CDZ96154 X.sub.5338 M6 179 96 G A
CDZ96154 X.sub.5339 M6 179 1525 G A
CDZ96154 X.sub.5340 M6 179 1780 C T
CDZ96154 X.sub.5341 M6 188 815 C T
CED80060 X.sub.5342 M6 188 1174 C T
CED80060 X.sub.5343 M6 188 2163 G A
CED80060 X.sub.5344 M6 188 2170 G A
CED80060 X.sub.5345 M6 247 102 G A
CED80061 X.sub.5346 M6 247 989 C T
CED80061 X.sub.5347 M6 247 1053 G a
CED80061 X.sub.5348 M6 7 160 T C
X.sub.5349 M6 8 1110 C T
X.sub.5350 M6 11 154 A C
X.sub.5351 M6 11 158 C T
X.sub.5352 M6 15 28 C G
X.sub.5353 M6 24 5850 C T
CDZ96160 X.sub.5354 M6 24 68660 C T
CDZ96181 X.sub.5355 M6 24 118860 C T
CDZ96200 X.sub.5356 M6 24 180340 G A
CDZ96216 X.sub.5357 M6 24 266697 G A
CDZ96242 X.sub.5358 M6 24 307114 G A
CDZ96255 X.sub.5359 M6 24 320852 A T
CDZ96259 X.sub.5360 M6 24 335171 C T
CDZ96265 X.sub.5361 M6 24 340663 T C
CDZ96265 X.sub.5362 M6 24 349340 C T
CDZ96270 X.sub.5363 M6 24 363770 C T
CDZ96275 X.sub.5364 M6 24 420108 G A
CDZ96291 X.sub.5365 M6 24 470687 G A
CDZ96308 X.sub.5366 M6 24 474698 G A
CDZ96308 X.sub.5367 M6 26 245 G A
X.sub.5368 M6 27 445 C T
X.sub.5369 M6 27 1012 A C
X.sub.5370 M6 27 1013 T A
X.sub.5371 M6 32 158 C T
CDZ96332 X.sub.5372 M6 32 215 C T
CDZ96332 X.sub.5373 M6 32 2438 C T
CDZ96332 X.sub.5374 M6 32 2734 C T
CDZ96332 X.sub.5375 M6 32 2821 C T
CDZ96332 X.sub.5376 M6 32 3067 C T
CDZ96332 X.sub.5377 M6 32 3506 C T
CDZ96332 X.sub.5378 M6 32 3562 G A
CDZ96332 X.sub.5379 M6 33 399 T A
CED82002 X.sub.5380 M6 33 45488 C T
CED82012 X.sub.5381 M6 33 79913 G A
CED82024 X.sub.5382 M6 33 105276 G A
CED82036 X.sub.5383 M6 33 109397 G A
CED82038 X.sub.5384 M6 33 192563 C T
CED82066 X.sub.5385 M6 33 198050 C T
CED82067 X.sub.5386 M6 33 205554 C T
CED82069 X.sub.5387 M6 33 215436 C T
CED82071 X.sub.5388 M6 33 223703 G A
CED82075 X.sub.5389 M6 33 226363 G A
CED82075 X.sub.5390 M6 33 257786 C T
CED82084 X.sub.5391 M6 33 260027 G A
CED82084 X.sub.5392 M6 33 274627 G A
CED82091 X.sub.5393 M6 33 283808 C T
CED82093 X.sub.5394 M6 33 304408 C T
CED82099 X.sub.5395 M6 33 311532 G A
CED82101 X.sub.5396 M6 33 312032 G A
CED82101 X.sub.5397 M6 33 318242 G A
CED82105 X.sub.5398 M6 33 326016 T C
CED82108 X.sub.5399 M6 33 327840 C T
CED82108 X.sub.5400 M6 33 341890 G A
CED82113 X.sub.5401 M6 33 374131 A G
CED82121- CED82122 X.sub.5402 M6 33 374134 A G
CED82121- CED82122 X.sub.5403 M6 33 374137 A T
CED82121- CED82122 X.sub.5404 M6 33 374150 A C
CED82121- CED82122 X.sub.5405 M6 33 382577 C T
CED82122 X.sub.5406 M6 33 385155 T C
CED82122 X.sub.5407 M6 33 385319 A C
CED82122 X.sub.5408 M6 33 385527 C T
CED82122 X.sub.5409 M6 33 397625 C T
CED82125 X.sub.5410 M6 33 448815 G A
CED82144 X.sub.5411 M6 33 455451 C T
CED82146 X.sub.5412 M6 33 509127 C T
CED82166 X.sub.5413 M6 33 556726 C T
CED82183 X.sub.5414 M6 33 639242 G A
CED82208 X.sub.5415 M6 33 652012 G A
CED82212 X.sub.5416 M6 33 699423 C T
CED82227 X.sub.5417 M6 33 729705 C T
CED82234 X.sub.5418 M6 33 774105 G A
CED82248 X.sub.5419 M6 33 792965 G A
CED82256 X.sub.5420 M6 33 816048 C T
CED82262 X.sub.5421 M6 33 917771 A T
CED82294 X.sub.5422 M6 33 928554 A T
CED82297 X.sub.5423 M6 33 936350 T A
CED82300 X.sub.5424 M6 33 936356 G A
CED82300 X.sub.5425 M6 33 936571 A G
CED82300 X.sub.5426 M6 33 936600 G A
CED82300 X.sub.5427 M6 33 938992 C T
CED82300 X.sub.5428 M6 33 983105 G A
CED82315 X.sub.5429 M6 33 1043825 C T
CED82333 X.sub.5430 M6 33 1049699 G A
CED82334 X.sub.5431 M6 33 1126411 A G
CED82358 X.sub.5432 M6 33 1127676 G A
CED82358 X.sub.5433 M6 33 1138444 C T
CED82363 X.sub.5434 M6 33 1165914 G A
CED82372 X.sub.5435 M6 33 1169999 G A
CED82372 X.sub.5436 M6 33 1191727 C T
CED82379 X.sub.5437 M6 33 1205966 G A
CED82382 X.sub.5438 M6 33 1246468 C T
CED82392 X.sub.5439 M6 33 1277762 G A
CED82402 X.sub.5440 M6 33 1311181 G A
CED82413 X.sub.5441 M6 33 1324395 G A
CED82417 X.sub.5442 M6 33 1333932 G A
CED82421 X.sub.5443 M6 33 1339376 C T
CED82424 X.sub.5444 M6 33 1396438 C T
CED82442 X.sub.5445 M6 33 1399499 C T
CED82444 X.sub.5446 M6 33 1406738 G A
CED82444 X.sub.5447 M6 33 1431034 G A
CED82451 X.sub.5448 M6 33 1470375 C T
CED82465 X.sub.5449 M6 33 1499347 G A
CED82472 X.sub.5450 M6 33 1502644 G A
CED82474 X.sub.5451 M6 33 1544767 A C
CED82485- CED82486 X.sub.5452 M6 33 1587443 C T
CED82497 X.sub.5453 M6 33 1596242 C T
CED82498 X.sub.5454 M6 33 1638726 G A
CED82513 X.sub.5455 M6 33 1642659 G A
CED82515 X.sub.5456 M6 33 1666106 C T
CED82522 X.sub.5457 M6 33 1682149 C T
CED82526 X.sub.5458 M6 33 1700000 G A
CED82534 X.sub.5459 M6 33 1739035 G A
CED82544 X.sub.5460 M6 33 1767636 C T
CED82552 X.sub.5461 M6 33 1778220 C A
CED82556 X.sub.5462 M6 33 1780044 G A
CED82555 X.sub.5463 M6 33 1823362 C T
CED82571 X.sub.5464 M6 33 1862200 G A
CED82582 X.sub.5465 M6 33 1887401 C T
CED82591 X.sub.5466 M6 33 1888706 C T
CED82592 X.sub.5467 M6 33 1889585 G A
CED82592 X.sub.6468 M6 33 1964763 G A
CED82621 X.sub.5469 M6 33 1975079 G A
CED82625 X.sub.5470 M6 33 2010230 C T
CED82636 X.sub.5471 M6 33 2054662 G A
CED82654 X.sub.5472 M6 36 320 G A
X.sub.5473 M6 36 1056 G A
X.sub.5474 M6 36 1295 C T
X.sub.5475 M6 36 1461 A T
X.sub.5476 M6 42 804 C T
CDZ96333 X.sub.5477 M6 42 1559 G A
CDZ96333 X.sub.5478 M6 48 563 C T
X.sub.5479 M6 48 565 T C
X.sub.5480 M6 48 576 G A
X.sub.5481 M6 48 580 T A
X.sub.5482 M6 50 145 G A
X.sub.5483 M6 52 17234 A T
CED82668 X.sub.5484 M6 52 128353 G A
CED82702 X.sub.5485 M6 52 144382 C T
CED82709 X.sub.5486 M6 52 145060 G A
CED82708 X.sub.5487 M6 52 150382 C T
CED82712 X.sub.5488 M6 52 151974 C T
CED82712 X.sub.5489 M6 52 183986 C T
CED82722 X.sub.5490 M6 52 203253 A G
CED82730 X.sub.5491 M6 52 207354 C T
CED82730 X.sub.5492 M6 52 244305 G A
CED82734 X.sub.5493 M6 52 284733 G A
CED82747 X.sub.5494 M6 52 316848 C T
CED82758 X.sub.5495 M6 52 321045 C T
CED82760 X.sub.5496 M6 52 346628 G A
CED82769 X.sub.5497 M6 52 390095 G A
CED82784 X.sub.5498 M6 52 390988 C T
CED82785 X.sub.5499 M6 52 395374 G A
CED82786 X.sub.5500 M6 52 398723 C T
CED82786 X.sub.5501 M6 52 398728 C T
CED82786 X.sub.5502 M6 52 516267 C T
CED82823 X.sub.5503 M6 52 548788 G A
CED82835 X.sub.5504 M6 52 552099 G A
CED82837 X.sub.5505 M6 52 552173 G A
CED82837 X.sub.5506 M6 52 595806 C T
CED82851 X.sub.5507 M6 52 631479 C T
CED82860 X.sub.5508 M6 52 692048 C T
CED82884 X.sub.5509 M6 52 737403 G A
CED82903 X.sub.5510 M6 52 737419 G A
CED82903 X.sub.5511 M6 52 817452 T A
CED82928 X.sub.5512 M6 52 819924 C T
CED82929 X.sub.5513 M6 52 840755 C T
CED82935 X.sub.5514 M6 52 849671 G A
CED82940 X.sub.5515 M6 52 861376 C T
CED82946 X.sub.5516 M6 52 938650 G A
CED82973 X.sub.5517 M6 52 967316 A T
CED82984 X.sub.5518 M6 52 967701 T A
CED82983 X.sub.5519 M6 52 977048 G A
CED82990 X.sub.5520 M6 52 1003899 G A
CED83001 X.sub.5521 M6 52 1010006 C T
CED83002 X.sub.5522 M6 52 1020804 G A
CED83005 X.sub.5523 M6 52 1021202 C T
CED83005 X.sub.5524 M6 52 1029498 G A
CED83007 X.sub.5525 M6 52 1043011 C T
CED83012 X.sub.5526 M6 52 1067895 C T
CED83020 X.sub.5527 M6 52 1158103 C T
CED83051 X.sub.5528 M6 52 1219894 C T
CED83071 X.sub.5529 M6 52 1363357 G A
CED83122 X.sub.5530 M6 52 1363405 C T
CED83123 X.sub.5531 M6 52 1379155 G A
CED83128 X.sub.5532 M6 52 1389320 G A
CED83130 X.sub.5533 M6 52 1392238 C T
CED83130 X.sub.5534 M6 52 1399439 G A
CED83134 X.sub.5535 M6 52 1481345 G A
CED83165 X.sub.5536 M6 52 1526796 G A
CED83181 X.sub.5537 M6 52 1583655 C T
CED83206 X.sub.5538 M6 52 1590982 C T
CED83207 X.sub.5539 M6 52 1665003 A G
CED83235 X.sub.5540 M6 52 1708900 A G
CED83249 X.sub.5541 M6 52 1715136 C T
CED83250 X.sub.5542 M6 52 1716210 C T
CED83250 X.sub.5543 M6 52 1760440 G A
CED83266 X.sub.5544 M6 52 1793370 G A
CED83275 X.sub.5545 M6 52 1796780 G A
CED83279 X.sub.5546 M6 52 1807309 G A
CED83283 X.sub.5547 M6 52 1861665 C T
CED83301 X.sub.5548 M6 52 1861681 G A
CED83301 X.sub.5549 M6 52 1871310 C T
CED83304 X.sub.5550 M6 52 1874150 G T
CED83305 X.sub.5551 M6 52 1893352 G A
CED83313 X.sub.5552 M6 52 1963875 G A
CED83335 X.sub.5553 M6 52 1987096 G A
CED83341 X.sub.5554 M6 52 2041781 C T
CED83355 X.sub.5555 M6 52 2047954 G A
CED83358 X.sub.5556 M6 52 2048018 G A
CED83358 X.sub.5557 M6 52 2050245 G A
CED83359 X.sub.5558 M6 52 2081390 G A
CED83367 X.sub.5559 M6 52 2120665 C T
CED83376 X.sub.5560 M6 52 2136885 A G
CED83382 X.sub.5561 M6 52 2162878 G A
CED83392 X.sub.5562 M6 52 2222126 C T
CED83410 X.sub.5563 M6 52 2264881 G A
CED83424 X.sub.5564 M6 52 2265219 C T
CED83425 X.sub.5565 M6 52 2266378 C T
CED83423 X.sub.5566 M6 52 2296638 G A
CED83432 X.sub.5567 M6 52 2327266 C T
CED83445 X.sub.5568 M6 52 2330881 G A
CED83447 X.sub.5569 M6 52 2355303 G A
CED83453 X.sub.5570 M6 52 2373120 C T
CED83456 X.sub.5571 M6 52 2400778 C T
CED83463 X.sub.5572 M6 52 2415283 C T
CED83469 X.sub.5573 M6 52 2443575 G A
CED83476 X.sub.5574 M6 52 2575090 A G
CED83525 X.sub.5575 M6 53 26291 G A
CDZ96348 X.sub.5576 M6 53 55702 C T
CDZ96359 X.sub.5577 M6 54 4815 G A
CDZ96384 X.sub.5578 M6 54 4816 A T
CDZ96384 X.sub.5579 M6 54 4817 G C
CDZ96384 X.sub.5580 M6 54 4821 G A
CDZ96384 X.sub.5581 M6 54 60769 G A
CDZ96403 X.sub.5582 M6 54 87947 G A
CDZ96410 X.sub.5583 M6 54 106086 G T
CDZ96416 X.sub.5584 M6 54 114442 G A
CDZ96419 X.sub.5585 M6 54 119439 C T
CDZ96420 X.sub.5586 M6 54 194230 G A
CDZ96446 X.sub.5587 M6 54 195804 G A
CDZ96447 X.sub.5588 M6 54 202467 C T
CDZ96448 X.sub.5589 M6 54 206494 G A
CDZ96450 X.sub.5590 M6 54 207267 G A
CDZ96450 X.sub.5591 M6 54 233698 G A
CDZ96457 X.sub.5592 M6 54 240326 G A
CDZ96462 X.sub.5593 M6 54 258379 G A
CDZ96465 X.sub.5594 M6 54 274617 A T
CDZ96471 X.sub.5595 M6 54 316790 T G
CDZ96487 X.sub.5596 M6 54 357149 G A
CDZ96496 X.sub.5597 M6 54 370320 G A
CDZ96499 X.sub.5598 M6 54 391223 A G
CDZ96509 X.sub.5599 M6 54 402099 G A
CDZ96511 X.sub.5600 M6 54 427542 C T
CDZ96520 X.sub.5601 M6 54 478527 C T
CDZ96537 X.sub.5602 M6 54 564688 C T
CDZ96566 X.sub.5603 M6 54 733193 T C
CDZ96619 X.sub.5604 M6 54 743396 G A
CDZ96621 X.sub.5605 M6 58 93 T C
X.sub.5606 M6 64 2756 A C
CDZ96626 X.sub.5607 M6 64 2767 G A
CDZ96626 X.sub.5608 M6 64 2770 C T
CDZ96626 X.sub.5609 M6 64 2783 C T
CDZ96626 X.sub.5610 M6 64 5037 G A
CDZ96626 X.sub.5611 M6 67 111 G A
X.sub.5612 M6 67 176 C T
X.sub.5613 M6 69 29006 G A
CED83534 X.sub.5614 M6 69 70304 C T
CED83551 X.sub.5615 M6 69 84820 G A
CED83555 X.sub.5616 M6 69 89393 G A
CED83556 X.sub.5617 M6 69 97985 G A
CED83559 X.sub.5618 M6 69 107920 C T
CED83561 X.sub.5619 M6 69 123084 C T
CED83563 X.sub.5620 M6 69 201005 G A
CED83595 X.sub.5621 M6 69 205541 G A
CED83597 X.sub.5622 M6 69 258091 G A
CED83614 X.sub.5623 M6 69 293602 G A
CED83626 X.sub.5624 M6 69 384418 G A
CED83656 X.sub.5625 M6 69 415659 C T
CED83665 X.sub.5626 M6 69 431248 G A
CED83671 X.sub.5627 M6 69 461986 G A
CED83680 X.sub.5628 M6 69 473113 G A
CED83684 X.sub.5629 M6 69 482073 G T
CED83685 X.sub.5630 M6 69 483131 G A
CED83687 X.sub.5631 M6 69 555744 G A
CED83711 X.sub.5632 M6 69 556138 C T
CED83710 X.sub.5633 M6 69 585845 G A
CED83722 X.sub.5634 M6 69 614468 T C
CED83733 X.sub.5635 M6 69 631511 G A
CED83742 X.sub.5636 M6 69 637299 T C
CED83744 X.sub.5637 M6 69 675579 G A
CED83760 X.sub.5638 M6 69 676581 G A
CED83760 X.sub.5639 M6 69 676853 G A
CED83759 X.sub.5640 M6 69 678406 C T
CED83759 X.sub.5641 M6 69 681141 G A
CED83762 X.sub.5642 M6 69 682770 C T
CED83763 X.sub.5643 M6 69 743019 C T
CED83782 X.sub.5644 M6 69 786726 C T
CED83794 X.sub.5645 M6 69 840268 C T
CED83808 X.sub.5646 M6 69 865820 C T
CED83814 X.sub.5647 M6 69 869706 G A
CED83815 X.sub.5648 M6 69 872470 G A
CED83815 X.sub.5649 M6 69 892199 G A
CED83822 X.sub.5650 M6 69 894019 G A
CED83821 X.sub.5651 M6 69 894462 C T
CED83821 X.sub.5652 M6 69 949982 C T
CED83842 X.sub.5653 M6 69 971219 C T
CED83847 X.sub.5654 M6 69 988364 G A
CED83857 X.sub.5655 M6 69 1065858 G A
CED83881 X.sub.5656 M6 69 1084824 G A
CED83891 X.sub.5657 M6 69 1084835 C T
CED83891 X.sub.5658 M6 69 1084848 A G
CED83891 X.sub.5659 M6 69 1084866 A G
CED83891 X.sub.5660 M6 69 1084931 C T
CED83891 X.sub.5661 M6 69 1102164 C T
CED83897 X.sub.5662 M6 69 1109785 C T
CED83899 X.sub.5663 M6 69 1109813 A G
CED83899 X.sub.3664 M6 69 1109818 A G
CED83899 X.sub.5665 M6 69 1109819 T A
CED83899 X.sub.5666 M6 69 1109823 T C
CED83899 X.sub.5667 M6 69 1109830 A G
CED83899 X.sub.5668 M6 69 1109831 C A
CED83899 X.sub.5669 M6 69 1109835 A G
CED83899 X.sub.5670 M6 69 1110546 T A
CED83899 X.sub.5671 M6 69 1111789 C T
CED83899 X.sub.5672 M6 69 1152012 G A
CED83915 X.sub.5673 M6 69 1179032 G A
CED83923 X.sub.5674 M6 69 1192333 G A
CED83928 X.sub.5675 M6 69 1205454 C T
CED83932 X.sub.5676 M6 69 1212727 G A
CED83933 X.sub.5677 M6 69 1218409 G A
CED83936 X.sub.5678 M6 69 1260087 G A
CED83949 X.sub.5679 M6 69 1342909 G A
CED83975 X.sub.5680 M6 69 1372486 C T
CED83987 X.sub.5681 M6 69 1377243 C T
CED83989 X.sub.5682 M6 69 1396045 G A
CED83994 X.sub.5683 M6 69 1411237 C T
CED84001 X.sub.5684 M6 69 1411421 C T
CED83999 X.sub.5685 M6 69 1412234 G A
CED83999 X.sub.5686 M6 69 1416914 G A
CED84002 X.sub.5687 M6 69 1421240 C T
CED84004 X.sub.5688 M6 69 1493453 C T
CED84026 X.sub.5689 M6 69 1577606 C T
CED84055 X.sub.5690 M6 69 1590302 G A
CED84059 X.sub.5691 M6 69 1642484 C T
CED84076 X.sub.5692 M6 69 1652288 C T
CED84077 X.sub.5693 M6 69 1674261 C T
CED84084 X.sub.5694 M6 69 1688555 C T
CED84088 X.sub.5695 M6 69 1694047 C T
CED84089 X.sub.5696 M6 69 1706650 G A
CED84095 X.sub.5697 M6 69 1714728 G A
CED84097 X.sub.5698 M6 69 1720246 C T
CED84101 X.sub.5699 M6 69 1790823 C T
CED84125 X.sub.5700 M6 69 1792597 C T
CED84126 X.sub.5701 M6 69 1800584 G A
CED84129 X.sub.5702 M6 69 1803813 G A
CED84128 X.sub.5703 M6 69 1854739 G A
CED84145 X.sub.5704 M6 69 1924621 C T
CED84172 X.sub.5705 M6 69 1960423 G A
CED84188 X.sub.5706 M6 69 1967529 C T
CED84189 X.sub.5707 M6 69 1968848 A G
CED84189 X.sub.5708 M6 69 1978129 C G
CED84193 X.sub.5709 M6 69 1978321 A G
CED84193 X.sub.5710 M6 69 2001469 C T
CED84197 X.sub.5711 M6 69 2089848 A G
CED84232 X.sub.5712 M6 69 2089870 C T
CED84232 X.sub.5713 M6 69 2089876 C A
CED84232 X.sub.5714 M6 69 2099165 C T
CED84233 X.sub.5715 M6 69 2099418 C T
CED84233 X.sub.5716 M6 69 2099421 A T
CED84233 X.sub.5717 M6 69 2099423 G T
CED84233 X.sub.5718 M6 69 2099452 C G
CED84233 X.sub.5719 M6 69 2101188 T C
CED84234 X.sub.5720 M6 69 2160207 C T
CED84255 X.sub.5721 M6 69 2180564 C T
CED84264 X.sub.5722 M6 69 2226113 C T
CED84272 X.sub.5723 M6 69 2231926 G A
CED84274 X.sub.5724 M6 69 2260222 C T
CED84282 X.sub.5725 M6 69 2438727 C T
CED84343 X.sub.5726 M6 69 2483433 G A
CED84352 X.sub.5727 M6 70 22 T C
X.sub.5728 M6 72 93 T C
X.sub.5729 M6 72 584 G A
X.sub.5730 M6 72 856 C T
X.sub.5731 M6 72 1163 C T
X.sub.5732 M6 77 34978 G T
CDZ96642 X.sub.5733 M6 77 39842 G A
CDZ96646 X.sub.5734 M6 77 84022 G A
CDZ96659 X.sub.5735 M6 78 1865 C T
CED84359 X.sub.5736 M6 78 6333 G A
CED84360 X.sub.5737 M6 78 89958 C T
CED84387 X.sub.5738 M6 78 100169 G A
CED84388 X.sub.5739 M6 78 109325 G A
CED84390 X.sub.5740 M6 78 127873 G A
CED84395 X.sub.5741 M6 78 139788 C A
CED84399 X.sub.5742 M6 78 238854 C T
CED84430 X.sub.5743 M6 78 263828 T C
CED84438 X.sub.5744 M6 78 276353 T C
CED84440 X.sub.5745 M6 78 276361 T C
CED84440 X.sub.5746 M6 78 276362 C T
CED84440 X.sub.5747 M6 78 281454 C A
CED84441 X.sub.5748 M6 78 292068 C T
CED84442 X.sub.5749 M6 78 292139 A T
CED84442 X.sub.5750 M6 78 298141 C G
CED84443 X.sub.5751 M6 78 299166 G A
CED84443 X.sub.5752 M6 78 299644 G A
CED84443 X.sub.5753 M6 78 302257 G A
CED84443 X.sub.5754 M6 78 311586 C T
CED84447 X.sub.5755 M6 78 404944 G A
CED84475 X.sub.5756 M6 78 404988 G A
CED84475 X.sub.5757 M6 78 487303 C T
CED84505 X.sub.5758 M6 78 517862 G A
CED84513 X.sub.5759 M6 78 611362 C T
CED84546 X.sub.5760 M6 78 646777 C T
CED84556 X.sub.5761 M6 78 653177 C T
CED84559 X.sub.5762 M6 78 658932 G A
CED84561 X.sub.5763 M6 78 708376 C T
CED84580 X.sub.5764 M6 78 763771 G A
CED84600 X.sub.5765 M6 78 774252 G A
CED84602 X.sub.5766 M6 78 853752 G A
CED84625 X.sub.5767 M6 78 952815 G A
CED84662 X.sub.5768 M6 78 952860 G A
CED84662 X.sub.5769 M6 78 976799 C T
CED84672 X.sub.5770 M6 78 988551 G A
CED84675 X.sub.5771 M6 78 1023381 G A
CED84688 X.sub.5772 M6 78 1086537 C T
CED84713 X.sub.5773 M6 78 1098373 G A
CED84716 X.sub.5774 M6 78 1112587 C T
CED84722 X.sub.5775 M6 78 1115511 G A
CED84723 X.sub.5776 M6 78 1155093 C T
CED84732 X.sub.5777 M6 78 1216573 C T
CED84752 X.sub.5778 M6 78 1266077 G A
CED84770 X.sub.5779 M6 78 1302286 C T
CED84782 X.sub.5780 M6 78 1317124 G A
CED84787 X.sub.5781 M6 78 1322274 G A
CED84790 X.sub.5782 M6 78 1344640 C T
CED84795 X.sub.5783 M6 78 1345792 G A
CED84797 X.sub.5784 M6 78 1406981 C T
CED84821 X.sub.5785 M6 78 1426722 C T
CED84829 X.sub.5786 M6 78 1463555 G A
CED84840 X.sub.5787 M6 78 1498179 G A
CED84852 X.sub.5788 M6 78 1520586 C T
CED84855 X.sub.5789 M6 78 1532973 G A
CED84857 X.sub.5790 M6 78 1549787 C T
CED84861 X.sub.5791 M6 78 1563246 C T
CED84865 X.sub.5792 M6 78 1568326 C T
CED84868 X.sub.5793 M6 78 1609850 C T
CED84880 X.sub.5794 M6 78 1642170 G A
CED84889 X.sub.5795 M6 78 1658512 G A
CED84896 X.sub.5796 M6 78 1660408 G A
CED84897 X.sub.5797 M6 78 1673601 C T
CED84903 X.sub.5798 M6 78 1705462 G A
CED84915 X.sub.5799 M6 78 1742796 G A
CED84926 X.sub.5800 M6 78 1745145 A G
CED84927 X.sub.5801 M6 78 1745162 C T
CED84927 X.sub.5802 M6 79 65 G A
CDZ96674 X.sub.5803 M6 79 6477 T C
CDZ96674- CDZ96675 X.sub.5804 M6 79 57804 G A
CDZ96687 X.sub.5805 M6 79 64133 C T
CDZ96688 X.sub.5806 M6 79 80215 C T
CDZ96695 X.sub.5807 M6 79 132683 C T
CDZ96713 X.sub.5808 M6 79 147578 G A
CDZ96719 X.sub.5809 M6 79 171814 C T
CDZ96727 X.sub.5810 M6 79 307021 C T
CDZ96777 X.sub.5811 M6 79 316481 C T
CDZ96779 X.sub.5812 M6 79 318883 G A
CDZ96779 X.sub.5813 M6 79 332458 G A
CDZ96785 X.sub.5814 M6 79 346823 G A
CDZ96789 X.sub.5815 M6 79 378247 C T
CDZ96800 X.sub.5816 M6 79 483118 T A
CDZ96836 X.sub.5817 M6 79 492523 C T
CDZ96842 X.sub.5818 M6 79 509666 C T
CDZ96848 X.sub.5819 M6 79 526910 C T
CDZ96854 X.sub.5820 M6 79 575411 C T
CDZ96868 X.sub.5821 M6 79 579674 G A
CDZ96871 X.sub.5822 M6 79 617057 C T
CDZ96882 X.sub.5823 M6 79 679140 C T
CDZ96904 X.sub.5824 M6 79 687842 T C
CDZ96908 X.sub.5825 M6 79 696174 G A
CDZ96911 X.sub.5826 M6 79 735053 T C
CDZ96928 X.sub.5827 M6 79 748083 G T
CDZ96929 X.sub.5828 M6 79 749308 A G
CDZ96930 X.sub.5829 M6 79 759195 T A
CDZ96931 X.sub.5830 M6 79 759403 C T
CDZ96931 X.sub.5831 M6 79 759589 G A
CDZ96932 X.sub.5832 M6 79 759659 G A
CDZ96931 X.sub.5833 M6 79 760430 T C
CDZ96932 X.sub.5834 M6 79 760891 A G
CDZ96932 X.sub.5835 M6 79 760988 G T
CDZ96932 X.sub.5836 M6 79 761056 T C
CDZ96932 X.sub.5837 M6 79 768537 A G
CDZ96933 X.sub.5838 M6 79 776301 C A
CDZ96934 X.sub.5839 M6 79 776304 G T
CDZ96934 X.sub.5840 M6 79 786064 A G
CDZ96934 X.sub.5841 M6 79 798799 C T
CDZ96939 X.sub.5842 M6 79 844705 T C
CDZ96954 X.sub.5843 M6 79 907000 C T
CDZ96976 X.sub.5844 M6 79 933234 G A
CDZ96987 X.sub.5845 M6 79 973493 C T
CDZ97000 X.sub.5846 M6 79 1000786 A G
CDZ97007 X.sub.5847 M6 79 1021855 G A
CDZ97016 X.sub.5848 M6 79 1044652 G A
CDZ97023 X.sub.5849 M6 79 1075960 G A
CDZ97034 X.sub.5850 M6 79 1107695 C T
CDZ97046 X.sub.5851 M6 79 1117040 C T
CDZ97047 X.sub.5852 M6 79 1123288 C T
CDZ97049 X.sub.5853 M6 79 1140763 G A
CDZ97053 X.sub.5854 M6 79 1167374 C T
CDZ97065 X.sub.5855 M6 79 1191202 G A
CDZ97070 X.sub.5856 M6 79 1211985 G A
CDZ97077 X.sub.5857 M6 79 1229129 G A
CDZ97086 X.sub.5858 M6 79 1231740 C T
CDZ97087 X.sub.5859 M6 79 1234552 G A
CDZ97087 X.sub.5860 M6 79 1318034 C T
CDZ97117 X.sub.5861 M6 79 1336766 C T
CDZ97121 X.sub.5862 M6 79 1344338 G A
CDZ97124 X.sub.5863 M6 79 1387800 G A
CDZ97135 X.sub.5864 M6 79 1394931 A T
CDZ97136 X.sub.5865 M6 79 1430954 G A
CDZ97152 X.sub.5866 M6 79 1472351 C T
CDZ97165 X.sub.5867 M6 79 1533781 C T
CDZ97185 X.sub.5868 M6 79 1540205 C T
CDZ97186 X.sub.5869 M6 79 1624415 G A
CDZ97217 X.sub.5870 M6 79 1658469 C T
CDZ97227 X.sub.5871 M6 79 1674448 G A
CDZ97228 X.sub.5872 M6 79 1704321 G A
CDZ97235 X.sub.5873 M6 79 1772244 G A
CDZ97258 X.sub.5874 M6 79 1797660 C T
CDZ97265 X.sub.5875 M6 79 1797676 G A
CDZ97265 X.sub.5876 M6 79 1842448 G A
CDZ97282 X.sub.5877 M6 79 1855037 A G
CDZ97285 X.sub.5878 M6 79 1859220 A G
CDZ97291 X.sub.5879 M6 79 1877329 G A
CDZ97295 X.sub.5880 M6 79 1912360 G A
CDZ97307 X.sub.5881 M6 79 1930688 G A
CDZ97315 X.sub.5882 M6 79 1938626 A C
CDZ97318 X.sub.5883 M6 79 2013361 C T
CDZ97344 X.sub.5884 M6 79 2052320 C T
CDZ97361 X.sub.5885 M6 79 2055184 G A
CDZ97361 X.sub.5886 M6 79 2113064 G A
CDZ97381 X.sub.5887 M6 79 2116476 C T
CDZ97380 X.sub.5888 M6 79 2121041 G A
CDZ97380 X.sub.5889 M6 79 2152573 C T
CDZ97392 X.sub.5890 M6 79 2188410 G A
CDZ97405 X.sub.5891 M6 79 2268540 C T
CDZ97435 X.sub.5892 M6 79 2304361 G A
CDZ97450 X.sub.5893 M6 79 2315869 A C
CDZ97452 X.sub.5894 M6 79 2323713 C T
CDZ97455 X.sub.5895 M6 79 2339881 C G
CDZ97460 X.sub.5896 M6 79 2340326 G A
CDZ97462 X.sub.5897 M6 81 210 G T
X.sub.5898 M6 85 512 A G
X.sub.5899 M6 85 516 G A
X.sub.5900 M6 85 521 C T
X.sub.5901 M6 85 522 A G
X.sub.5902 M6 88 119 C T
CDZ97464 X.sub.5903 M6 88 196 G A
CDZ97464 X.sub.5904 M6 88 898 C T
CDZ97464 X.sub.5905 M6 99 245 G A
X.sub.5906 M6 105 130 T A
CDZ97474 X.sub.5907 M6 107 278 A G
X.sub.5908 M6 109 396 T C
X.sub.5909 M6 113 264 T C
X.sub.5910 M6 118 396 C T
CDZ97478 X.sub.5911 M6 118 870 G A
CDZ97478 X.sub.5912 M6 118 1491 G A
CDZ97478 X.sub.5913 M6 121 318 A T
X.sub.5914 M6 121 1269 A T
X.sub.5915 M6 124 35211 G A
CDZ97488 X.sub.5916 M6 124 69730 G A
CDZ97501 X.sub.5917 M6 124 72117 G A
CDZ97501 X.sub.5918 M6 124 72760 G A
CDZ97501 X.sub.5919 M6 124 80266 C T
CDZ97504 X.sub.5920 M6 124 94611 G A
CDZ97507 X.sub.5921 M6 124 96777 C T
CDZ97508 X.sub.5922 M6 124 156052 G A
CDZ97524 X.sub.5923 M6 124 179336 C T
CDZ97533 X.sub.5924 M6 124 206541 G A
CDZ97541 X.sub.5925 M6 124 222249 C T
CDZ97547 X.sub.5926 M6 125 16379 G A
CDZ97565 X.sub.5927 M6 125 20772 G A
CDZ97566 X.sub.5928 M6 125 35864 T C
CDZ97573 X.sub.5929 M6 129 299 G A
CDZ97577 X.sub.5930 M6 129 433 G A
CDZ97577 X.sub.5931 M6 129 856 G A
CDZ97577 X.sub.5932 M6 129 1013 C T
CDZ97577 X.sub.5933 M6 130 674 C T
CDZ97578 X.sub.5934 M6 138 123 G T
X.sub.5935 M6 141 5649 C T
CDZ97582 X.sub.5936 M6 141 14167 G A
CDZ97586 X.sub.5937 M6 141 15764 C T
CDZ97587 X.sub.5938 M6 141 29260 G A
CDZ97594 X.sub.5939 M6 145 296 A G
X.sub.5040 M6 149 1663 A G
CDZ97598 X.sub.5941 M6 149 2076 T G
CDZ97598 X.sub.5942 M6 149 2453 C T
CDZ97598 X.sub.5943 M6 159 106 A C
X.sub.5944 M6 162 47699 G A
CDZ97619 X.sub.5945 M6 162 70405 A G
CDZ97625 X.sub.5946 M6 162 209584 C T
CDZ97670 X.sub.5947 M6 162 214099 G A
CDZ97671 X.sub.5948 M6 162 218351 G A
CDZ97671 X.sub.5949 M6 162 223407 C T
CDZ97674 X.sub.5950 M6 162 308369 T C
CDZ97702 X.sub.5951 M6 162 320785 G C
CDZ97703 X.sub.5952 M6 162 320786 T G
CDZ97703 X.sub.5953 M6 162 321070 C T
CDZ97703 X.sub.5954 M6 162 321073 A G
CDZ97703 X.sub.5955 M6 162 321460 C G
CDZ97703 X.sub.5956 M6 162 321463 A C
CDZ97703 X.sub.5957 M6 162 323651 T C
CDZ97703 X.sub.5958 M6 162 323735 A G
CDZ97703 X.sub.5959 M6 162 324114 T C
CDZ97703 X.sub.5960 M6 162 324139 C T
CDZ97703 X.sub.5961 M6 162 324568 A G
CDZ97703 X.sub.5962 M6 162 360320 G A
CDZ97714 X.sub.5963 M6 162 387700 C T
CDZ97725 X.sub.5964 M6 162 408274 C T
CDZ97733 X.sub.5965 M6 162 423180 C T
CDZ97740 X.sub.5966 M6 162 424391 C T
CDZ97740 X.sub.5967 M6 162 444123 T C
CDZ97748 X.sub.5968 M6 162 467207 C T
CDZ97755 X.sub.5969 M6 162 476267 C T
CDZ97760 X.sub.5970 M6 162 481093 G A
CDZ97761 X.sub.5971 M6 162 491906 G A
CDZ97764 X.sub.5972 M6 162 492101 G A
CDZ97764 X.sub.5973 M6 162 501886 C T
CDZ97769 X.sub.5974 M6 162 507949 G A
CDZ97771 X.sub.5975 M6 162 521996 G C
CDZ97777 X.sub.5976 M6 162 618658 C T
CDZ97808 X.sub.5977 M6 162 632311 G A
CDZ97814 X.sub.5978 M6 162 633321 G A
CDZ97814 X.sub.5979 M6 162 633633 G A
CDZ97814 X.sub.5980 M6 162 638083 C T
CDZ97814 X.sub.5981 M6 162 640005 C T
CDZ97815 X.sub.5982 M6 162 680645 G A
CDZ97826 X.sub.5983 M6 162 716116 C T
CDZ97836 X.sub.5984 M6 162 738479 G A
CDZ97842 X.sub.5985 M6 162 738675 G A
CDZ97842 X.sub.5986 M6 162 738686 C T
CDZ97842 X.sub.5987 M6 162 808830 G A
CDZ97869 X.sub.5988 M6 162 825209 G A
CDZ97877 X.sub.5989 M6 162 871911 C T
CDZ97890 X.sub.5990 M6 162 914850 C T
CDZ97904 X.sub.5991 M6 162 972973 G A
CDZ97925 X.sub.5992 M6 163 225 G A
X.sub.5993 M6 163 727 A G
X.sub.5994 M6 175 120 G C
X.sub.5995 M6 185 21 C T
CDZ97957 X.sub.5996 M6 189 1306 C T
CDZ97961 X.sub.5997 M6 189 64473 G A
CDZ97979 X.sub.5998 M6 189 126573 G A
CDZ97996 X.sub.5999 M6 189 194647 A G
CDZ98020 X.sub.6000 M6 189 194665 A G
CDZ98020 X.sub.6001 M6 189 211865 C T
CDZ98028 X.sub.6002 M6 189 212649 C T
CDZ98028 X.sub.6003 M6 189 323680 C T
CDZ98063 X.sub.6004 M6 189 344057 C T
CDZ98068 X.sub.6005 M6 189 371247 G A
CDZ98078 X.sub.6006 M6 189 394551 C T
CDZ98085 X.sub.6007 M6 191 342 A G
CDZ98107 X.sub.6008 M6 191 347 C T
CDZ98107 X.sub.6009 M6 191 427 C T
CDZ98107 X.sub.6010 M6 191 451 C T
CDZ98107 X.sub.6011 M6 191 487 A G
CDZ98107 X.sub.6012 M6 197 624 C T
CDZ98111 X.sub.6013 M6 198 202 C A
X.sub.6014 M6 198 203 G A
X.sub.6015 M6 198 238 C T
X.sub.6016 M6 198 265 C T
X.sub.6017 M6 199 688 C T
X.sub.6018 M6 199 911 C T
X.sub.6019 M6 199 971 C T
X.sub.6020 M6 199 1218 C T
X.sub.6021 M6 202 171 C T
X.sub.6022 M6 205 360 C T
CDZ98112 X.sub.6023 M6 205 981 C T
CDZ98112 X.sub.6024 M6 206 406 G A
X.sub.6025 M6 208 117 G A
X.sub.6026 M6 208 476 G A
X.sub.6027 M6 208 616 G A
X.sub.6028 M6 208 935 G A
X.sub.6029 M6 209 312 C T
CDZ98113 X.sub.6030 M6 223 93 G A
CDZ98118 X.sub.6031 M6 223 102 A G
CDZ98118 X.sub.6032 M6 223 133 A G
CDZ98118 X.sub.6033 M6 223 150 T C
CDZ98118 X.sub.6034 M6 223 155 A C
CDZ98118 X.sub.6035 M6 223 158 T C
CDZ98118 X.sub.6036 M6 223 160 C T
CDZ98118 X.sub.6037 M6 223 175 G A
CDZ98118 X.sub.6038 M6 223 177 A G
CDZ98118 X.sub.6039 M6 223 188 A G
CDZ98118 X.sub.6040 M6 223 192 C A
CDZ98118 X.sub.6041 M6 223 194 T C
CDZ98118 X.sub.6042 M6 223 195 T G
CDZ98118 X.sub.6043 M6 223 197 T C
CDZ98118 X.sub.6044 M6 223 202 G C
CDZ98118 X.sub.6045 M6 225 317 C T
X.sub.6046 M6 227 202 G A
X.sub.6047 M6 232 340 G A
CDZ98119 X.sub.6048 M6 232 1379 C T
CDZ98119 X.sub.6049 M6 232 1521 C T
CDZ98119 X.sub.6050 M6 232 1662 G A
CDZ98119 X.sub.6051 M6 232 1761 C T
CDZ98119 X.sub.6052 M6 232 2027 C T
CDZ98119 X.sub.6053 M6 232 3060 C T
CDZ98120 X.sub.6054 M6 232 3284 C T
CDZ98119 X.sub.6055 M6 232 4437 G A
CDZ98121 X.sub.6056 M6 232 4561 C T
CDZ98120 X.sub.6057 M6 242 7334 C T
CDZ98125 X.sub.6058 M6 242 41710 G A
CDZ98131 X.sub.6059 M6 242 50262 G A
CDZ98135 X.sub.6060 M6 242 84132 G A
CDZ98146 X.sub.6061 M6 242 88037 G A
CDZ98147 X.sub.6062 M6 242 107587 G A
CDZ98153 X.sub.6063 M6 242 112244 G A
CDZ98154 X.sub.6064 M6 242 149113 C T
CDZ98165 X.sub.6065 M6 242 213986 G A
CDZ98185 X.sub.6066 M6 242 227271 C T
CDZ98191 X.sub.6067 M6 242 233088 G A
CDZ98193 X.sub.6068 M6 242 233141 G A
CDZ98193 X.sub.6069 M6 242 310353 G A
CDZ98216 X.sub.6070 M6 242 342570 C T
CDZ98229 X.sub.6071 M6 242 357209 G A
CDZ98233 X.sub.6072 M6 242 374897 G A
CDZ98238 X.sub.6073 M6 242 376713 G A
CDZ98238 X.sub.6074 M6 242 379812 C T
CDZ98238 X.sub.6075 M6 242 404132 G A
CDZ98248 X.sub.6076 M6 242 405825 G A
CDZ98250 X.sub.6077 M6 242 412676 G A
CDZ98249 X.sub.6078 M6 242 437941 G A
CDZ98258 X.sub.6079 M6 242 454709 C T
CDZ98263 X.sub.6080 M6 242 485936 G A
CDZ98270 X.sub.6081 M6 242 492389 G A
CDZ98274 X.sub.6082 M6 242 514780 C T
CDZ98282 X.sub.6083 M6 242 528340 G A
CDZ98288 X.sub.6084 M6 242 530144 G A
CDZ98288 X.sub.6085 M6 242 542663 G A
CDZ98290 X.sub.6086 M6 242 548679 C T
CDZ98292 X.sub.6087 M6 242 559999 G A
CDZ98297 X.sub.6088 M6 242 602456 G A
CDZ98308 X.sub.6089 M6 242 602531 G A
CDZ98308 X.sub.6090 M6 242 604704 C T
CDZ98309 X.sub.6091 M6 242 628488 G A
CDZ98317 X.sub.6092 M6 248 99 A G
X.sub.6093 M6 249 206 G A
CED84929 X.sub.6094 M6 249 5307 C T
CED84929 X.sub.6095 M6 249 52397 G A
CED84947 X.sub.6096 M6 249 72016 C T
CED84950 X.sub.6097 M6 249 157550 C T
CED84983 X.sub.6098 M6 249 191304 C T
CED84988 X.sub.6099 M6 249 231983 C T
CED85003 X.sub.6100 M6 249 238318 C T
CED85003 X.sub.6101 M6 249 239775 G A
CED85004 X.sub.6102 M6 249 253494 C T
CED85008 X.sub.6103 M6 249 272075 C T
CED85013 X.sub.6104 M6 249 294853 C T
CED85019 X.sub.6105 M6 249 305975 G A
CED85023 X.sub.6106 M6 249 342990 G A
CED85036 X.sub.6107 M6 249 371117 G A
CED85047 X.sub.6108 M6 249 371535 G A
CED85048 X.sub.6109 M6 249 377814 G A
CED85051 X.sub.6110 M6 249 436175 G A
CED85073 X.sub.6111 M6 249 485782 C T
CED85089 X.sub.6112 M6 249 500195 C T
CED85093 X.sub.6113 M6 249 501310 C T
CED85093 X.sub.6114 M6 249 501510 T C
CED85093 X.sub.6115 M6 249 532943 A G
CED85099 X.sub.6116 M6 249 598579 C T
CED85125 X.sub.6117 M6 249 627104 C T
CED85133 X.sub.6118 M6 249 637944 G A
CED85135 X.sub.6119 M6 249 654772 C T
CED85141 X.sub.6120 M6 249 660408 G A
CED85144 X.sub.6121 M6 249 665383 G A
CED85144 X.sub.6122 M6 249 709695 G T
CED85164 X.sub.6123 M6 249 743970 G A
CED85171 X.sub.6124 M6 249 751427 G A
CED85174 X.sub.6125 M6 249 794731 C T
CED85186 X.sub.6126 M6 249 803215 C T
CED85186 X.sub.6127 M6 249 854220 G A
CED85201 X.sub.6128 M6 249 886063 G A
CED85208 X.sub.6129 M6 249 911274 C T
CED85218 X.sub.6130 M6 249 932606 C T
CED85223 X.sub.6131 M6 249 934305 G A
CED85225 X.sub.6132 M6 249 945434 C T
CED85227 X.sub.6133 M6 249 945727 C T
CED85227 X.sub.6134 M6 249 969333 G T
CED85238 X.sub.6135 M6 249 977170 C T
CED85242 X.sub.6136 M6 249 989520 C T
CED85243 X.sub.6137 M6 249 1014098 C T
CED85252 X.sub.6138 M6 249 1014926 C T
CED85252 X.sub.6139 M6 249 1050123 C T
CED85262 X.sub.6140 M6 249 1076166 C T
CED85270 X.sub.6141 M6 249 1076333 G T
CED85270 X.sub.6142 M6 249 1088841 T C
CED85274 X.sub.6143 M6 249 1127638 C T
CED85286 X.sub.6144 M6 249 1144309 G A
CED85291 X.sub.6145 M6 249 1176977 G A
CED85303 X.sub.6146 M6 249 1195367 G A
CED85307 X.sub.6147 M6 249 1230068 C T
CED85319 X.sub.6148 M6 249 1234239 C T
CED85319 X.sub.6149 M6 249 1245242 G A
CED85322 X.sub.6150 M6 249 1263893 C T
CED85327 X.sub.6151 M6 249 1299472 C T
CED85343 X.sub.6152 M6 249 1305184 G A
CED85345 X.sub.6153 M6 249 1331428 G A
CED85352 X.sub.6154 M6 249 1457529 G A
CED85398 X.sub.6155 M6 249 1475590 G A
CED85404 X.sub.6156 M6 249 1498029 T C
CED85415 X.sub.6157 M6 249 1498823 T C
CED85414 X.sub.6158 M6 249 1498829 C T
CED85414 X.sub.6159 M6 249 1502631 G T
CED85416 X.sub.6160 M6 249 1502641 T A
CED85416 X.sub.6161 M6 249 1505138 G A
CED85416 X.sub.6162 M6 249 1505634 T G
CED85416 X.sub.6163 M6 249 1518591 T A
CED85419 X.sub.6164 M6 249 1519431 A G
CED85419 X.sub.6165 M6 249 1520073 T C
CED85420 X.sub.6166 M6 249 1520089 C T
CED85420 X.sub.6167 M6 249 1520169 C T
CED85420 X.sub.6168 M6 249 1520420 G C
CED85420 X.sub.6169 M6 249 1531574 C T
CED85423 X.sub.6170 M6 249 1535511 G A
CED85423 X.sub.6171 M6 249 1567124 G A
CED85432 X.sub.6172 M6 249 1585540 T C
CED85439 X.sub.6173 M6 249 1599907 C T
CED85444 X.sub.6174 M6 249 1619036 G A
CED85450 X.sub.6175 M6 249 1636931 G A
CED85455 X.sub.6176 M6 249 1653615 T G
CED85457 X.sub.6177 M6 249 1653962 C T
CED85458 X.sub.6178 M6 249 1666185 C T
CED85460 X.sub.6179 M6 249 1726777 C T
CED85474 X.sub.6180 M6 249 1729264 C T
CED85476 X.sub.6181 M6 249 1732115 G A
CED85476 X.sub.6182 M6 249 1734722 G A
CED85477 X.sub.6183 M6 249 1768844 C T
CED85489 X.sub.6184 M6 249 1780551 A G
CED85493 X.sub.6185 M6 249 1780569 A G
CED85493 X.sub.6186 M6 249 1782994 G A
CED85493 X.sub.6187 M6 249 1801965 G A
CED85501 X.sub.6188 M6 249 1803575 C T
CED85502 X.sub.6189 M6 249 1804835 G A
CED85502 X.sub.6190 M6 249 1880762 G A
CED85525 X.sub.6191 M6 249 1944026 G A
CED85545 X.sub.6192 M6 249 1988505 C T
CED85560 X.sub.6193 M6 249 2015272 G A
CED85567 X.sub.6194 M6 249 2027477 G A
CED85573 X.sub.6195 M6 249 2047401 C T
CED85581 X.sub.6196 M6 249 2054064 C T
CED85583 X.sub.6197 M6 249 2063221 G A
CED85586 X.sub.6198 M6 249 2110956 C T
CED85603 X.sub.6199 M6 249 2131353 C T
CED85609 X.sub.6200 M6 249 2163304 G A
CED85618 X.sub.6201 M6 249 2198205 G A
CED85628 X.sub.6202 M6 249 2223626 G A
CED85633 X.sub.6203 M6 249 2255547 G C
CED85640 X.sub.6204 M6 252 512 C T
X.sub.6205 M6 252 524 C T
X.sub.6206 M6 258 836 A G
X.sub.6207 M6 258 907 A G
X.sub.6208 M6 258 1139 A T
X.sub.6209 M6 259 91 G C
X.sub.6210 M6 260 156 G A
X.sub.6211 M6 262 4049 G A
CDZ98330 X.sub.6212 M6 262 12289 C T
CDZ98333 X.sub.6213 M6 262 30347 G A
CDZ98338 X.sub.6214 M6 262 30359 G A
CDZ98338 X.sub.6215 M6 262 39621 C T
CDZ98342 X.sub.6216 M6 262 81226 G A
CDZ98358 X.sub.6217 M6 262 109833 C T
CDZ98369 X.sub.6218 M6 262 139442 C T
CDZ98375 X.sub.6219 M6 262 148151 C T
CDZ98375 X.sub.6220 M6 262 164438 G A
CDZ98383 X.sub.6221 M6 262 175142 G A
CDZ98388 X.sub.6222 M6 262 201531 G A
CDZ98396 X.sub.6223 M6 262 242371 C T
CDZ98411 X.sub.6224 M6 262 314812 T C
CDZ98435 X.sub.6225 M6 262 319302 G A
CDZ98436 X.sub.6226 M6 262 345538 C T
CDZ98448 X.sub.6227 M6 262 373766 C T
CDZ98456 X.sub.6228 M6 262 380519 C T
CDZ98457 X.sub.6229 M6 262 397539 G A
CDZ98463 X.sub.6230 M6 262 420102 G A
CDZ98468 X.sub.6231 M6 262 446956 C T
CDZ98477 X.sub.6232 M6 262 471054 C T
CDZ98487 X.sub.6233 M6 262 498239 C T
CDZ98496 X.sub.6234 M6 262 503840 G A
CDZ98499 X.sub.6235 M6 262 510643 G A
CDZ98502 X.sub.6236 M6 262 539428 G A
CDZ98514 X.sub.6237 M6 262 539452 A G
CDZ98514 X.sub.6238 M6 262 539470 A G
CDZ98514 X.sub.6239 M6 262 539588 A G
CDZ98514 X.sub.6240 M6 262 552414 C T
CDZ98518 X.sub.6241 M6 262 557280 G A
CDZ98518 X.sub.6242 M6 262 560713 G A
CDZ98519 X.sub.6243 M6 262 562795 C T
CDZ98521 X.sub.6244 M6 262 567591 G A
CDZ98524 X.sub.6245 M6 262 567801 G A
CDZ98524 X.sub.6246 M6 262 618198 G A
CDZ98538 X.sub.6247 M6 262 639962 A G
CDZ98544 X.sub.6248 M6 262 653920 A G
CDZ98545 X.sub.6249 M6 262 656031 C A
CDZ98545 X.sub.6250 M6 262 668764 C T
CDZ98545 X.sub.6251 M6 262 691577 C T
CDZ98551 X.sub.6252 M6 262 722911 C A
CDZ98562 X.sub.6253 M6 262 751209 C T
CDZ98572 X.sub.6254 M6 262 759042 A T
CDZ98575 X.sub.6255 M6 262 822734 G A
CDZ98597 X.sub.6256 M6 262 835874 C T
CDZ98601 X.sub.6257 M6 262 865999 G A
CDZ98613 X.sub.6258 M6 262 950365 A T
CDZ98640 X.sub.6259 M6 262 971713 G A
CDZ98649 X.sub.6260 M6 262 1016286 C T
CDZ98661 X.sub.6261 M6 262 1021485 C T
CDZ98663 X.sub.6262 M6 262 1076581 G A
CDZ98679 X.sub.6263 M6 262 1080137 G A
CDZ98679 X.sub.6264 M6 262 1209662 G A
CDZ98723 X.sub.6265 M6 262 1226072 C T
CDZ98730 X.sub.6266 M6 262 1237021 C T
CDZ98735 X.sub.6267 M6 262 1277604 G A
CDZ98747 X.sub.6268 M6 262 1305361 G A
CDZ98753 X.sub.6269 M6 262 1329643 C T
CDZ98760 X.sub.6270 M6 262 1349561 G A
CDZ98766 X.sub.6271 M6 262 1351116 A G
CDZ98766 X.sub.6272 M6 262 1408928 G A
CDZ98786 X.sub.6273 M6 262 1424293 G A
CDZ98791 X.sub.6274 M6 262 1455677 G A
CDZ98804 X.sub.6275 M6 262 1505836 G A
CDZ98823 X.sub.6276 M6 262 1546246 C T
CDZ98833 X.sub.6277 M6 262 1549845 C T
CDZ98837 X.sub.6278 M6 262 1550311 C T
CDZ98836 X.sub.6279 M6 262 1550456 C T
CDZ98837 X.sub.6280 M6 262 1558074 G A
CDZ98840 X.sub.6281 M6 262 1577316 G A
CDZ98844 X.sub.6282 M6 262 1615762 G A
CDZ98855 X.sub.6283 M6 262 1694625 C T
CDZ98878 X.sub.6284 M6 262 1706076 G A
CDZ98885 X.sub.6285 M6 262 1709112 G A
CDZ98884 X.sub.6286 M6 262 1711527 G A
CDZ98886 X.sub.6287 M6 262 1716385 G A
CDZ98887 X.sub.6288 M6 265 272 A G
CDZ98889 X.sub.6289 M6 266 252 C T
X.sub.6290 M6 267 133 T C
X.sub.6291 M6 267 134 C T
X.sub.6292 M7 22 1643 C T
CED80056 X.sub.6293 M7 22 2524 G A
CED80056 X.sub.6294 M7 28 236 G A
CDZ96150 X.sub.6295 M7 28 377 G A
CDZ96150 X.sub.6296 M7 28 1506 C T
CDZ96150 X.sub.6297 M7 28 1677 C T
CDZ96150 X.sub.6298 M7 43 464 G A
CDZ96151 X.sub.6299 M7 43 753 C T
CDZ96151 X.sub.6300 M7 43 757 G A
CDZ96151 X.sub.6301 M7 43 1527 C T
CDZ96151 X.sub.6302 M7 43 1748 G A
CDZ96151 X.sub.6303 M7 43 1928 C T
CDZ96151 X.sub.6304 M7 55 1405 C T
CED80057 X.sub.6305 M7 62 26 T A
CDZ96152 X.sub.6306 M7 62 27 T C
CDZ96152 X.sub.6307 M7 62 55 T A
CDZ96152 X.sub.6308 M7 62 403 C T
CDZ96152 X.sub.6309 M7 62 669 C T
CDZ96152 X.sub.6310 M7 62 875 G A
CDZ96152 X.sub.6311 M7 102 339 C T
CDZ96153 X.sub.6312 M7 102 951 G A
CDZ96153 X.sub.6313 M7 102 1042 G A
CDZ96153 X.sub.6314 M7 102 2334 G A
CDZ96153 X.sub.6315 M7 102 2590 C T
CDZ96153 X.sub.6316 M7 102 3427 C T
CDZ96153 X.sub.6317 M7 176 358 G A
CED80058 X.sub.6318 M7 176 1872 G A
CED80058 X.sub.6319 M7 176 1980 G A
CED80058 X.sub.6320 M7 176 2335 A G
CED80058 X.sub.6321 M7 176 2349 G A
CED80058 X.sub.6322 M7 179 93 A G
CDZ96154 X.sub.6323 M7 179 96 G A
CDZ96154 X.sub.6324 M7 179 1177 G A
CDZ96154 X.sub.6325 M7 179 1525 G A
CDZ96154 X.sub.6326 M7 179 1739 G A
CDZ96154 X.sub.6327 M7 179 1780 C T
CDZ96154 X.sub.6328 M7 179 2324 G A
CDZ96154 X.sub.6329 M7 188 815 C T
CED80060 X.sub.6330 M7 188 1174 C T
CED80060 X.sub.6331 M7 188 2163 G A
CED80060 X.sub.6332 M7 188 2170 G A
CED80060 X.sub.6333 M7 247 102 G A
CED80061 X.sub.6334 M7 247 989 C T
CED80061 X.sub.6335 M7 247 1053 G A
CED80061 X.sub.6336 M7 247 1454 C T
CED80061 X.sub.6337 M7 4 781 G A
X.sub.6338 M7 7 160 T C
X.sub.6339 M7 8 1110 C T
X.sub.6340 M7 11 154 A C
X.sub.6341 M7 11 158 C T
X.sub.6342 M7 15 28 C G
X.sub.6343 M7 15 462 C T
X.sub.6344 M7 15 464 C A
X.sub.6345 M7 15 465 C T
X.sub.6346 M7 24 513 T C
CDZ96160 X.sub.6347 M7 24 520 C G
CDZ96160 X.sub.6348 M7 24 5850 C T
CDZ96160 X.sub.6349 M7 24 168850 C T
CDZ96214 X.sub.6350 M7 24 172698 G A
CDZ96215 X.sub.6351 M7 24 180340 G A
CDZ96216 X.sub.6352 M7 24 197593 C T
CDZ96224 X.sub.6353 M7 24 266697 G A
CDZ96242 X.sub.6354 M7 24 307114 G A
CDZ96255 X.sub.6355 M7 24 340663 T C
CDZ96265 X.sub.6356 M7 24 349340 C T
CDZ96270 X.sub.6357 M7 24 349352 G A
CDZ96270 X.sub.6358 M7 24 363770 C T
CDZ96275 X.sub.6359 M7 24 382911 C T
CDZ96282 X.sub.6360 M7 24 400418 C T
CDZ96287 X.sub.6361 M7 24 420108 G A
CDZ96291 X.sub.6362 M7 24 470687 G A
CDZ96308 X.sub.6363 M7 24 474698 G A
CDZ96308 X.sub.6364 M7 24 476097 C T
CDZ96309 X.sub.6365 M7 24 488439 G T
CDZ96315 X.sub.6366 M7 24 513701 G C
CDZ96326 X.sub.6367 M7 27 445 C T
X.sub.6368 M7 27 1012 A C
X.sub.6369 M7 27 1013 T A
X.sub.6370 M7 32 158 C T
CDZ96332 X.sub.6371 M7 32 215 C T
CDZ96332 X.sub.6372 M7 32 2438 C T
CDZ96332 X.sub.6373 M7 32 2734 C T
CDZ96332 X.sub.6374 M7 32 2821 C T
CDZ96332 X.sub.6375 M7 32 3067 C T
CDZ96332 X.sub.6376 M7 32 3500 C T
CDZ96332 X.sub.6377 M7 32 3562 G A
CDZ96332 X.sub.6378 M7 33 399 T A
CED82002 X.sub.6379 M7 33 20227 G A
CED82006 X.sub.6380 M7 33 24784 C T
CED82008 X.sub.6381 M7 33 45488 C T
CED82012 X.sub.6382 M7 33 79913 G A
CED82024 X.sub.6383 M7 33 105276 G A
CED82036 X.sub.6384 M7 33 109397 G A
CED82038 X.sub.6385 M7 33 129884 G A
CED82045 X.sub.6386 M7 33 165059 C T
CED82056 X.sub.6387 M7 33 192563 C T
CED82066 X.sub.6388 M7 33 215436 C T
CED82071 X.sub.6389 M7 33 223703 G A
CED82075 X.sub.6390 M7 33 257786 C T
CED82084 X.sub.6391 M7 33 260027 G A
CED82084 X.sub.6392 M7 33 274627 G A
CED82091 X.sub.6393 M7 33 283808 C T
CED82093 X.sub.6394 M7 33 317713 G A
CED82104 X.sub.6395 M7 33 327840 C T
CED82108 X.sub.6396 M7 33 341890 G A
CED82113 X.sub.6397 M7 33 374131 A G
CED82121- CED82122 X.sub.6398 M7 33 374134 A G
CED82121- CED82122 X.sub.6399 M7 33 374137 A T
CED82121- CED82122 X.sub.6400 M7 33 374141 C T
CED82121- CED82122 X.sub.6401 M7 33 374150 A C
CED82121- CED82122 X.sub.6402 M7 33 375339 A G
CED82121- CED82122 X.sub.6403 M7 33 375366 T C
CED82121- CED82122 X.sub.6404 M7 33 382577 C T
CED82122 X.sub.6405 M7 33 382832 G T
CED82122 X.sub.6406 M7 33 385319 A C
CED82122 X.sub.6407 M7 33 385527 C T
CED82122 X.sub.6408 M7 33 386225 G A
CED82124 X.sub.6409 M7 33 388969 G T
CED82124 X.sub.6410 M7 33 432188 G A
CED82137 X.sub.6411 M7 33 448815 G A
CED82144 X.sub.6412 M7 33 453975 C T
CED82147 X.sub.6413 M7 33 455451 C T
CED82146 X.sub.6414 M7 33 481361 G A
CED82157 X.sub.6415 M7 33 505339 C T
CED82165 X.sub.6416 M7 33 509127 C T
CED82166 X.sub.6417 M7 33 626521 C T
CED82203 X.sub.6418 M7 33 690180 C T
CED82224 X.sub.6419 M7 33 693516 C T
CED82225 X.sub.6420 M7 33 699423 C T
CED82227 X.sub.6421 M7 33 704096 T A
CED82227 X.sub.6422 M7 33 704097 T C
CED82227 X.sub.6423 M7 33 715901 C T
CED82231 X.sub.6424 M7 33 729705 C T
CED82234 X.sub.6425 M7 33 794549 C T
CED82254 X.sub.6426 M7 33 800536 G A
CED82259 X.sub.6427 M7 33 822184 G A
CED82264 X.sub.6428 M7 33 829825 C T
CED82271 X.sub.6429 M7 33 917545 A G
CED82294 X.sub.6430 M7 33 917558 G A
CED82294 X.sub.6431 M7 33 928726 C T
CED82295 X.sub.6432 M7 33 933316 C T
CED82299 X.sub.6433 M7 33 936350 T A
CED82300 X.sub.6434 M7 33 936356 G A
CED82300 X.sub.6435 M7 33 936571 A G
CED82300 X.sub.6436 M7 33 936600 G A
CED82300 X.sub.6437 M7 33 938992 C T
CED82300 X.sub.6438 M7 33 971503 C T
CED82307 X.sub.6439 M7 33 995886 G A
CED82318 X.sub.6440 M7 33 1038506 C T
CED82330 X.sub.6441 M7 33 1049699 G A
CED82334 X.sub.6442 M7 33 1088320 C T
CED82349 X.sub.6443 M7 33 1122362 C T
CED82358 X.sub.6444 M7 33 1126814 G A
CED82358 X.sub.6445 M7 33 1138444 C T
CED82363 X.sub.6446 M7 33 1165914 G A
CED82372 X.sub.6447 M7 33 1191727 C T
CED82379 X.sub.6448 M7 33 1291620 C T
CED82406 X.sub.6449 M7 33 1324395 G A
CED82417 X.sub.6450 M7 33 1339376 C T
CED82424 X.sub.6451 M7 33 1367015 C T
CED82432 X.sub.6452 M7 33 1396438 C T
CED82442 X.sub.6453 M7 33 1460436 C T
CED82462 X.sub.6454 M7 33 1467702 C T
CED82463 X.sub.6455 M7 33 1470375 C T
CED82465 X.sub.6456 M7 33 1499347 G A
CED82472 X.sub.6457 M7 33 1502644 G A
CED82474 X.sub.6458 M7 33 1515369 G A
CED82478 X.sub.6459 M7 33 1535434 A T
CED82483 X.sub.6460 M7 33 1538001 G A
CED82483 X.sub.6461 M7 33 1544767 A C
CED82485- CED82486 X.sub.6462 M7 33 1544951 C G
CED82485- CED82486 X.sub.6463 M7 33 1585699 C T
CED82497 X.sub.6464 M7 33 1587443 C T
CED82497 X.sub.6465 M7 33 1596242 C T
CED82498 X.sub.6466 M7 33 1628197 G A
CED82510 X.sub.6467 M7 33 1638726 G A
CED82513 X.sub.6468 M7 33 1642659 G A
CED82515 X.sub.6469 M7 33 1666106 C T
CED82522 X.sub.6470 M7 33 1675912 C T
CED82525 X.sub.6471 M7 33 1700000 G A
CED82534 X.sub.6472 M7 33 1714997 G A
CED82538 X.sub.6473 M7 33 1752414 G A
CED82547 X.sub.6474 M7 33 1767636 C T
CED82552 X.sub.6475 M7 33 1780044 G A
CED82555 X.sub.6476 M7 33 1826223 G A
CED82573 X.sub.6477 M7 33 1841263 G A
CED82576 X.sub.6478 M7 33 1860991 G A
CED82583 X.sub.6479 M7 33 1862200 G A
CED82582 X.sub.6480 M7 33 1887401 C T
CED82591 X.sub.6481 M7 33 1938614 G A
CED82612 X.sub.6482 M7 33 1950090 G A
CED82614 X.sub.6483 M7 33 1967112 C T
CED82622 X.sub.6484 M7 33 1975079 G A
CED82625 X.sub.6485 M7 33 2010230 C T
CED82636 X.sub.6486 M7 33 2014235 C T
CED82637 X.sub.6487 M7 33 2033881 C T
CED82645 X.sub.6488 M7 33 2054662 G A
CED82654 X.sub.6489 M7 36 320 G A
X.sub.6490 M7 36 1056 G A
X.sub.6491 M7 36 1295 C T
X.sub.6492 M7 36 1461 A T
X.sub.6493 M7 42 804 C T
CDZ96333 X.sub.6494 M7 42 1559 G A
CDZ96333 X.sub.6495 M7 49 400 C T
X.sub.6496 M7 50 145 G A
X.sub.6497 M7 52 3042 A G
CED82664 X.sub.6498 M7 52 63859 C T
CED82686 X.sub.6499 M7 52 144382 C T
CED82709 X.sub.6500 M7 52 145060 G A
CED82708 X.sub.6501 M7 52 151974 C T
CED82712 X.sub.6502 M7 52 183986 C T
CED82722 X.sub.6503 M7 52 187553 C T
CED82724 X.sub.6504 M7 52 203253 A G
CED82730 X.sub.6505 M7 52 207354 C T
CED82730 X.sub.6506 M7 52 239820 A T
CED82734 X.sub.6507 M7 52 239821 A G
CED82734 X.sub.6508 M7 52 239825 T C
CED82734 X.sub.6509 M7 52 239827 A G
CED82734 X.sub.6510 M7 52 240075 G C
CED82734 X.sub.6511 M7 52 240241 T C
CED82734 X.sub.6512 M7 52 240245 A C
CED82734 X.sub.6513 M7 52 244305 G A
CED82734 X.sub.6514 M7 52 268499 G A
CED82740 X.sub.6515 M7 52 284733 G A
CED82747 X.sub.6516 M7 52 346628 G A
CED82769 X.sub.6517 M7 52 390095 G A
CED82784 X.sub.6518 M7 52 390988 C T
CED82785 X.sub.6519 M7 52 395374 G A
CED82786 X.sub.6520 M7 52 398723 C T
CED82786 X.sub.6521 M7 52 398728 C T
CED82786 X.sub.6522 M7 52 487472 C T
CED82814 X.sub.6523 M7 52 516267 C T
CED82823 X.sub.6524 M7 52 532992 G A
CED82831 X.sub.6525 M7 52 548788 G A
CED82835 X.sub.6526 M7 52 552099 G A
CED82837 X.sub.6527 M7 52 552173 G A
CED82837 X.sub.6528 M7 52 595806 C T
CED82851 X.sub.6529 M7 52 631479 C T
CED82860 X.sub.6530 M7 52 638622 G A
CED82862 X.sub.6531 M7 52 679670 G A
CED82877 X.sub.6532 MZ 52 737419 G A
CED82903 X.sub.6533 M7 52 817452 T A
CED82928 X.sub.6534 M7 52 840755 C T
CED82935 X.sub.6535 M7 52 849671 G A
CED82940 X.sub.6536 M7 52 868578 C T
CED82948 X.sub.6537 M7 52 870083 G A
CED82949 X.sub.6538 M7 52 938650 G A
CED82973 X.sub.6539 M7 52 967316 A T
CED82984 X.sub.6540 M7 52 967701 T A
CED82983 X.sub.6541 M7 52 1003899 G A
CED83001 X.sub.6542 M7 52 1004724 G A
CED83001 X.sub.6543 M7 52 1010006 C T
CED83002 X.sub.6544 M7 52 1029498 G A
CED83007 X.sub.6545 M7 52 1043011 C T
CED83012 X.sub.6546 M7 52 1067895 C T
CED83020 X.sub.6547 M7 52 1151398 G A
CED83046 X.sub.6548 M7 52 1158103 C T
CED83051 X.sub.6549 M7 52 1219894 C T
CED83071 X.sub.6550 M7 52 1227910 G A
CED83074 X.sub.6551 M7 52 1240590 A T
CED83078 X.sub.6552 M7 52 1292343 G A
CED83098 X.sub.6553 M7 52 1328337 T A
CED83112 X.sub.6554 M7 52 1363357 G A
CED83122 X.sub.6555 M7 52 1363405 C T
CED83123 X.sub.6556 M7 52 1373998 C T
CED83125 X.sub.6557 M7 52 1381652 C T
CED83129 X.sub.6558 M7 52 1389320 G A
CED83130 X.sub.6559 M7 52 1392238 C T
CED83130 X.sub.6560 M7 52 1399439 G A
CED83134 X.sub.6561 M7 52 1474315 G A
CED83164 X.sub.6562 M7 52 1475408 C T
CED83166 X.sub.6563 M7 52 1481345 G A
CED83165 X.sub.6564 M7 52 1509004 G A
CED83177 X.sub.6565 M7 52 1520883 C T
CED83179 X.sub.6566 M7 52 1526796 G A
CED83181 X.sub.6567 M7 52 1562633 C T
CED83195 X.sub.6568 M7 52 1583655 C T
CED83206 X.sub.6569 M7 52 1639254 C T
CED83227 X.sub.6570 M7 52 1650115 C T
CED83229 X.sub.6571 M7 52 1662924 G A
CED83236 X.sub.6572 M7 52 1708900 A G
CED83249 X.sub.6573 M7 52 1716210 C T
CED83250 X.sub.6574 M7 52 1793370 G A
CED83275 X.sub.6575 M7 52 1807309 G A
CED83283 X.sub.6576 M7 52 1826635 G A
CED83289 X.sub.6577 M7 52 1864608 G A
CED83303 X.sub.6578 M7 52 1871310 C T
CED83304 X.sub.6579 M7 52 1874150 G T
CED83305 X.sub.6580 M7 52 1874531 C T
CED83306 X.sub.6581 M7 52 1888989 C T
CED83312 X.sub.6582 M7 52 1893352 G A
CED83313 X.sub.6583 M7 52 1915927 G A
CED83315 X.sub.6584 M7 52 1938393 C T
CED83322 X.sub.6585 M7 52 1968215 A G
CED83335 X.sub.6586 M7 52 1969873 C T
CED83333 X.sub.6587 M7 52 1987096 G A
CED83341 X.sub.6588 M7 52 1995167 G A
CED83342 X.sub.6589 M7 52 2041781 C T
CED83355 X.sub.6590 M7 52 2050245 G A
CED83359 X.sub.6591 M7 52 2081390 G A
CED83367 X.sub.6592 M7 52 2093148 C T
CED83368 X.sub.6593 M7 52 2120665 C T
CED83376 X.sub.6594 M7 52 2136885 A G
CED83382 X.sub.6595 M7 52 2162878 G A
CED83392 X.sub.6596 M7 52 2171271 C T
CED83395 X.sub.6597 M7 52 2258192 C T
CED83422 X.sub.6598 M7 52 2265219 C T
CED83425 X.sub.6599 M7 52 2266378 C T
CED83423 X.sub.6600 M7 52 2308421 T C
CED83439 X.sub.6601 M7 52 2327266 C T
CED83445 X.sub.6602 M7 52 2338728 G A
CED83451 X.sub.6603 M7 52 2367582 G A
CED83455 X.sub.6604 M7 52 2373120 C T
CED83456 X.sub.6605 M7 52 2373426 G A
CED83456 X.sub.6606 M7 52 2373448 C T
CED83456 X.sub.6607 M7 52 2400778 C T
CED83463 X.sub.6608 M7 52 2531584 C T
1CED83507 X.sub.6609 M7 52 2543220 C T
CED83509 X.sub.6610 M7 52 2574904 G T
CED83525 X.sub.6611 M7 52 2575090 A G
CED83525 X.sub.6612 M7 53 26291 G A
CDZ96348 X.sub.6613 M7 53 69664 C T
CDZ96363 X.sub.6614 M7 53 89575 C T
CDZ96369 X.sub.6615 M7 53 104248 G A
CDZ96376 X.sub.6616 M7 53 110192 C T
CDZ96376 X.sub.6617 M7 54 4815 G A
CDZ96384 X.sub.6618 M7 54 4816 A T
CDZ96384 X.sub.6619 M7 54 4817 G C
CDZ96384 X.sub.6620 M7 54 4821 G A
CDZ96384 X.sub.6621 M7 54 16963 C T
CDZ96386 X.sub.6622 M7 54 30229 T C
CDZ96390 X.sub.6623 M7 54 31207 G A
CDZ96392 X.sub.6624 M7 54 87947 G A
CDZ96410 X.sub.6625 M7 54 95921 C T
CDZ96413 X.sub.6626 M7 54 106086 G A
CDZ96416 X.sub.6627 M7 54 119439 C T
CDZ96420 X.sub.6628 M7 54 119791 C T
CDZ96419 X.sub.6629 M7 54 167759 A T
CDZ96438 X.sub.6630 M7 54 194230 G A
CDZ96446 X.sub.6631 M7 54 195804 G A
CDZ96447 X.sub.6632 M7 54 202467 C T
CDZ96448 X.sub.6633 M7 54 206494 G A
CDZ96450 X.sub.6634 M7 54 207267 G A
CDZ96450 X.sub.6635 M7 54 274617 A T
CDZ96471 X.sub.6636 M7 54 278479 C T
CDZ96474 X.sub.6637 M7 54 316790 T G
CDZ96487 X.sub.6638 M7 54 337228 G A
CDZ96488 X.sub.6639 M7 54 357149 G A
CDZ96496 X.sub.6640 M7 54 370320 G A
CDZ96499 X.sub.6641 M7 54 383172 C T
CDZ96506 X.sub.6642 M7 54 391223 A G
CDZ96509 X.sub.6643 M7 54 404968 C T
CDZ96513 X.sub.6644 M7 54 427542 C T
CDZ96520 X.sub.6645 M7 54 431404 C T
CDZ96520 X.sub.6646 M7 54 431851 C T
CDZ96520 X.sub.6647 M7 54 477453 C T
CDZ96537 X.sub.6648 M7 54 478527 C T
CDZ96537 X.sub.6649 M7 54 509857 G A
CDZ96544 X.sub.6650 M7 54 515478 A G
CDZ96546 X.sub.6651 M7 54 555986 G A
CDZ96563 X.sub.6652 M7 54 616268 A G
CDZ96581 X.sub.6653 M7 54 648472 G A
CDZ96590 X.sub.6654 M7 54 686223 C T
CDZ96602 X.sub.6655 M7 54 699570 G A
CDZ96609 X.sub.6656 M7 54 733193 T C
CDZ96619 X.sub.6657 M7 54 743396 G A
CDZ96621 X.sub.6658 M7 58 93 T C
X.sub.6659 M7 64 5037 G A
CDZ96626 X.sub.6660 M7 67 111 G A
X.sub.6661 M7 69 29006 G A
CED83534 X.sub.6662 M7 69 50642 C T
CED83543 X.sub.6663 M7 69 55826 G A
CED83545 X.sub.6664 M7 69 82710 G A
CED83554 X.sub.6665 M7 69 84820 G A
CED83555 X.sub.6666 M7 69 107920 C T
CED83561 X.sub.6667 M7 69 123084 C T
CED83563 X.sub.6668 M7 69 148757 C T
CED83575 X.sub.6669 M7 69 201005 G A
CED83595 X.sub.6670 M7 69 228938 C T
CED83603 X.sub.6671 M7 69 305997 C T
CED83631 X.sub.6672 M7 69 314003 C T
CED83634 X.sub.6673 M7 69 384418 G A
CED83656 X.sub.6674 M7 69 386371 C T
CED83657 X.sub.6675 M7 69 415659 C T
CED83665 X.sub.6676 M7 69 455639 G A
CED83677 X.sub.6677 M7 69 461021 C T
CED83680 X.sub.6678 M7 69 461986 G A
CED83680 X.sub.6679 M7 69 467686 C T
CED83681 X.sub.6680 M7 69 473113 G A
CED83684 X.sub.6681 M7 69 534495 C T
CED83704 X.sub.6682 M7 69 560348 G A
CED83713 X.sub.6688 M7 69 585845 G A
CED83722 X.sub.6684 M7 69 627928 C T
CED83740 X.sub.6685 M7 69 631511 G A
CED83742 X.sub.6686 M7 69 637299 T C
CED83744 X.sub.6687 M7 69 675579 G A
CED83760 X.sub.6688 M7 69 676581 G A
CED83760 X.sub.6689 M7 69 676853 G A
CED83759 X.sub.6690 M7 69 678406 C T
CED83759 X.sub.6691 M7 69 707651 G A
CED83771 X.sub.6692 M7 69 743019 C T
CED83782 X.sub.6693 M7 69 744021 C T
CED83780 X.sub.6694 M7 69 828676 C T
CED83805 X.sub.6695 M7 69 840268 C T
CED83808 X.sub.6696 M7 69 843668 G A
CED83809 X.sub.6697 M7 69 853384 C T
CED83809 X.sub.6698 M7 69 865820 C T
CED83814 X.sub.6699 M7 69 869706 G A
CED83815 X.sub.6700 M7 69 892199 G A
CED83822 X.sub.6701 M7 69 894462 C T
CED83821 X.sub.6702 M7 69 930700 C T
CED83835 X.sub.6703 M7 69 931399 T A
CED83835 X.sub.6704 M7 69 971219 C T
CED83847 X.sub.6705 M7 69 988364 G A
CED83857 X.sub.6706 M7 69 989781 G A
CED83858 X.sub.6707 M7 69 994927 C T
CED83859 X.sub.6708 M7 69 1017805 G A
CED83865 X.sub.6709 M7 69 1021695 G A
CED83868 X.sub.6710 M7 69 1042212 G A
CED83875 X.sub.6711 M7 69 1072756 G A
CED83886 X.sub.6712 M7 69 1080578 G A
CED83890 X.sub.6713 M7 69 1084824 G A
CED83891 X.sub.6714 M7 69 1084835 C T
CED83891 X.sub.6715 M7 69 1084848 A G
CED83891 X.sub.6716 M7 69 1084866 A G
CED83891 X.sub.6717 M7 69 1084931 C T
CED83891 X.sub.6718 M7 69 1102164 C T
CED83897 X.sub.6719 M7 69 1109785 C T
CED83899 X.sub.6720 M7 69 1109813 A G
CED83899 X.sub.6721 M7 69 1109818 A G
CED83899 X.sub.6722 M7 69 1109819 T A
CED83899 X.sub.6723 M7 69 1109823 T C
CED83899 X.sub.6724 M7 69 1109830 A G
CED83899 X.sub.6725 M7 69 1109831 C A
CED83899 X.sub.6726 M7 69 1109835 A G
CED83899 X.sub.6727 M7 69 1110547 A G
CED83899 X.sub.6728 M7 69 1110548 T C
CED83899 X.sub.6729 M7 69 1115486 C T
CED83902 X.sub.6730 M7 69 1152012 G A
CED83915 X.sub.6731 M7 69 1199155 C T
CED83929 X.sub.6732 M7 69 1205454 C T
CED83932 X.sub.6733 M7 69 1212727 G A
CED83933 X.sub.6734 M7 69 1218409 G A
CED83936 X.sub.6735 M7 69 1237631 T C
CED83942 X.sub.6736 M7 69 1260087 G A
CED83949 X.sub.6737 M7 69 1279557 G A
CED83959 X.sub.6738 M7 69 1285126 A G
CED83961 X.sub.6739 M7 69 1342909 G A
CED83975 X.sub.6740 M7 69 1372486 C T
CED83987 X.sub.6741 M7 69 1400546 G A
CED83995 X.sub.6742 M7 69 1411237 C T
CED84001 X.sub.6743 M7 69 1411421 C T
CED83999 X.sub.6744 M7 69 1423154 G A
CED84004 X.sub.6745 M7 69 1519151 C T
CED84034 X.sub.6746 M7 69 1521875 C T
CED84035 X.sub.6747 M7 69 1526612 T C
CED84036 X.sub.6748 M7 69 1530586 C T
CED84038 X.sub.6749 M7 69 1590302 G A
CED84059 X.sub.6750 M7 69 1642484 C T
CED84076 X.sub.6751 M7 69 1652288 C T
CED84077 X.sub.6752 M7 69 1674261 C T
CED84084 X.sub.6753 M7 69 1688555 C T
CED84088 X.sub.6754 M7 69 1714728 G A
CED84097 X.sub.6755 M7 69 1720116 G A
CED84102 X.sub.6756 M7 69 1771849 C T
CED84116 X.sub.6757 M7 69 1788929 G A
CED84124 X.sub.6758 M7 69 1790823 C T
CED84125 X.sub.6759 M7 69 1792597 C T
CED84126 X.sub.6760 M7 69 1800584 G A
CED84129 X.sub.6761 M7 69 1854739 G A
CED84145 X.sub.6762 M7 69 1878663 C T
CED84154 X.sub.6763 M7 69 1924621 C T
CED84172 X.sub.6764 M7 69 1957485 C T
CED84187 X.sub.6765 M7 69 1967529 C T
CED84189 X.sub.6766 M7 69 1968848 A G
CED84189 X.sub.6767 M7 69 1975946 G A
CED84193 X.sub.6768 M7 69 2001469 C T
CED84197 X.sub.6769 M7 69 2048332 C T
CED84217 X.sub.6770 M7 69 2075336 C T
CED84226 X.sub.6771 M7 69 2099418 C T
CED84233 X.sub.6772 M7 69 2113590 G A
CED84237 X.sub.6773 M7 69 2127656 T A
CED84242 X.sub.6774 M7 69 2160207 C T
CED84255 X.sub.6775 M7 69 2180564 C T
CED84264 X.sub.6776 M7 69 2226317 C T
CED84272 X.sub.6777 M7 69 2231926 G A
CED84274 X.sub.6778 M7 69 2240834 C T
CED84277 X.sub.6779 M7 69 2255001 G A
CED84282 X.sub.6780 M7 69 2283903 G A
CED84293 X.sub.6781 M7 69 2325544 C T
CED84307 X.sub.6782 M7 69 2438727 C T
CED84343 X.sub.6783 M7 69 2448630 C T
CED84344 X.sub.6784 M7 69 2481008 G A
CED84352 X.sub.6785 M7 69 2483433 G A
CED84352 X.sub.6786 M7 72 93 T C
X.sub.6787 M7 72 584 G A
X.sub.6788 M7 72 856 C T
X.sub.6789 M7 72 1163 C T
X.sub.6790 M7 77 18912 A G
CDZ96635 X.sub.6791 M7 77 26888 G A
CDZ96641 X.sub.6792 M7 77 34978 G T
CDZ96642 X.sub.6793 M7 77 39842 G A
CDZ96646 X.sub.6794 M7 77 84022 G A
CDZ96659 X.sub.6795 M7 77 105644 G A
CDZ96669 X.sub.6796 M7 78 6333 G A
CED84360 X.sub.6797 M7 78 26915 C T
CED84366 X.sub.6798 M7 78 35200 G A
CED84371 X.sub.6799 M7 78 66886 G A
CED84381 X.sub.6800 M7 78 158534 G A
CED84406 X.sub.6801 M7 78 238854 C T
CED84430 X.sub.6802 M7 78 263896 T C
CED84438 X.sub.6803 M7 78 281454 C A
CED84441 X.sub.6804 M7 78 292068 C T
CED84442 X.sub.6805 M7 78 298141 C G
CED84443 X.sub.6806 M7 78 299166 G A
CED84443 X.sub.6807 M7 78 299644 G A
CED84443 X.sub.6808 M7 78 302700 A G
CED84443 X.sub.6809 M7 78 302816 T C
CED84443 X.sub.6810 M7 78 304799 A C
CED84444 X.sub.6811 M7 78 333312 A G
CED84452 X.sub.6812 M7 78 386356 C T
CED84472 X.sub.6813 M7 78 444292 C T
CED84490 X.sub.6814 M7 78 480244 C T
CED84502 X.sub.6815 M7 78 492399 C T
CED84504 X.sub.6816 M7 78 626958 C A
CED84549 X.sub.6817 M7 78 658932 G A
CED84561 X.sub.6818 M7 78 666005 C T
CED84562 X.sub.6819 M7 78 710966 G A
CED84581 X.sub.6820 M7 78 715700 G A
CED84582 X.sub.6821 M7 78 718885 C T
CED84584 X.sub.6822 M7 78 763771 G A
CED84600 X.sub.6823 M7 78 774252 G A
CED84602 X.sub.6824 M7 78 853752 G A
CED84625 X.sub.6825 M7 78 895505 C T
CED84642 X.sub.6826 M7 78 928773 C T
CED84653 X.sub.6827 M7 78 939705 G A
CED84658 X.sub.6828 M7 78 952815 G A
CED84662 X.sub.6829 M7 78 952860 G A
CED84662 X.sub.6830 M7 78 976680 C T
CED84672 X.sub.6831 M7 78 976799 C T
CED84672 X.sub.6832 M7 78 1023381 G A
CED84688 X.sub.6833 M7 78 1029603 A T
CED84689 X.sub.6834 M7 78 1039555 C T
CED84695 X.sub.6835 M7 78 1077392 T C
CED84708 X.sub.6836 M7 78 1086537 C T
CED84713 X.sub.6837 M7 78 1111002 G A
CED84721 X.sub.6838 M7 78 1115511 G A
CED84723 X.sub.6839 M7 78 1199558 G A
CED84746 X.sub.6840 M7 78 1216573 C T
CED84752 X.sub.6841 M7 78 1289816 C T
CED84778 X.sub.6842 M7 78 1302286 C T
CED84782 X.sub.6843 M7 78 1315648 C T
CED84788 X.sub.6844 M7 78 1317124 G A
CED84787 X.sub.6845 M7 78 1320778 G A
CED84790 X.sub.6846 M7 78 1344640 C T
CED84795 X.sub.6847 M7 78 1426722 C T
CED84829 X.sub.6848 M7 78 1493542 C T
CED84851 X.sub.6849 M7 78 1532973 G A
CED84857 X.sub.6850 M7 78 1549659 G A
CED84862 X.sub.6851 M7 78 1568326 C T
CED84868 X.sub.6852 M7 78 1642170 G A
CED84889 X.sub.6853 M7 78 1658512 G A
CED84896 X.sub.6854 M7 78 1660408 G A
CED84897 X.sub.6855 M7 78 1674126 G A
CED84904 X.sub.6856 M7 78 1694684 C T
CED84912 X.sub.6857 M7 78 1721661 G A
CED84921 X.sub.6058 M7 78 1742796 G A
CED84926 X.sub.6859 M7 79 65 G A
CDZ96674 X.sub.6860 M7 79 133 A G
CDZ96674 X.sub.6861 M7 79 41271 C T
CDZ96684 X.sub.6862 M7 79 57804 G A
CDZ96687 X.sub.6863 M7 79 64658 C T
CDZ96688 X.sub.6864 M7 79 132683 C T
CDZ96713 X.sub.6865 M7 79 168708 C T
CDZ96727 X.sub.6866 M7 79 241350 C T
CDZ96753 X.sub.6867 M7 79 255780 G A
CDZ96757 X.sub.6868 M7 79 273231 G A
CDZ96764 X.sub.6869 M7 79 296092 G A
CDZ96772 X.sub.6870 M7 79 307021 C T
CDZ96777 X.sub.6871 M7 79 324145 C T
CDZ96781 X.sub.6872 M7 79 332458 G A
CDZ96785 X.sub.6873 M7 79 345646 G A
CDZ96789 X.sub.6874 M7 79 346823 G A
CDZ96789 X.sub.6875 M7 79 369258 G A
CDZ96793 X.sub.6876 M7 79 406184 G A
CDZ96808 X.sub.6877 M7 79 451849 G A
CDZ96827 X.sub.6878 M7 79 478890 C T
CDZ96834 X.sub.6879 M7 79 492523 C T
CDZ96842 X.sub.6880 M7 79 570874 C T
CDZ96867 X.sub.6881 M7 79 575411 C T
CDZ96868 X.sub.6882 M7 79 579674 G A
CDZ96871 X.sub.6883 M7 79 617057 C T
CDZ96882 X.sub.6884 M7 79 679140 C T
CDZ96904 X.sub.6885 M7 79 696174 G A
CDZ96911 X.sub.6886 M7 79 735053 T C
CDZ96928 X.sub.6887 M7 79 747717 A G
CDZ96929 X.sub.6888 M7 79 748083 G T
CDZ96929 X.sub.6889 M7 79 749595 A C
CDZ96930 X.sub.6890 M7 79 759195 T A
CDZ96931 X.sub.6891 M7 79 759403 C T
CDZ96931 X.sub.6892 M7 79 759589 G A
CDZ96932 X.sub.6893 M7 79 759659 G A
CDZ96931 X.sub.6894 M7 79 760458 G T
CDZ96932 X.sub.6895 M7 79 760891 A G
CDZ96932 X.sub.6896 M7 79 761056 T C
CDZ96932 X.sub.6897 M7 79 768537 A G
CDZ96933 X.sub.6898 M7 79 776112 A G
CDZ96934 X.sub.6899 M7 79 776150 G A
CDZ96934 X.sub.6900 M7 79 798799 C T
CDZ96939 X.sub.6901 M7 79 827202 G A
CDZ96946 X.sub.6902 M7 79 853944 T A
CDZ96957 X.sub.6903 M7 79 864204 C T
CDZ96959 X.sub.6904 M7 79 874161 G A
CDZ96965 X.sub.6905 M7 79 928047 G A
CDZ96986 X.sub.6906 M7 79 959497 C T
CDZ96997 X.sub.6907 M7 79 984226 C T
CDZ97004 X.sub.6908 M7 79 990910 C T
CDZ97004 X.sub.6909 M7 79 1000786 A G
CDZ97007 X.sub.6910 M7 79 1061879 G A
CDZ97030 X.sub.6911 M7 79 1069426 C T
CDZ97032 X.sub.6912 M7 79 1082233 G A
CDZ97037 X.sub.6913 M7 79 1117040 C T
CDZ97047 X.sub.6914 M7 79 1123288 C T
CDZ97049 X.sub.6915 M7 79 1140763 G A
CDZ97053 X.sub.6916 M7 79 1167374 C T
CDZ97065 X.sub.6917 M7 79 1229129 G A
CDZ97086 X.sub.6918 M7 79 1231740 C T
CDZ97087 X.sub.6919 M7 79 1279548 G A
CDZ97105 X.sub.6920 M7 79 1287496 C T
CDZ97107 X.sub.6921 M7 79 1318034 C T
CDZ97117 X.sub.6922 M7 79 1336766 C T
CDZ97121 X.sub.6923 M7 79 1344403 C T
CDZ97124 X.sub.6924 M7 79 1367232 C T
CDZ97129 X.sub.6925 M7 79 1430954 G A
CDZ97152 X.sub.6926 M7 79 1540205 C T
CDZ97186 X.sub.6927 M7 79 1541574 G A
CDZ97186 X.sub.6928 M7 79 1556423 C T
CDZ97191 X.sub.6929 M7 79 1624415 G A
CDZ97217 X.sub.6930 M7 79 1658469 C T
CDZ97227 X.sub.6931 M7 79 1674448 G A
CDZ97228 X.sub.6932 M7 79 1708225 C T
CDZ97238 X.sub.6933 M7 79 1797660 C T
CDZ97265 X.sub.6934 M7 79 1797676 G A
CDZ97265 X.sub.6935 M7 79 1842448 G A
CDZ97282 X.sub.6936 M7 79 1855037 A G
CDZ97285 X.sub.6937 M7 79 1859220 A G
CDZ97291 X.sub.6938 M7 79 1977783 G A
CDZ97330 X.sub.6939 M7 79 2013361 C T
CDZ97344 X.sub.6940 M7 79 2027861 C T
CDZ97350 X.sub.6941 M7 79 2055184 G A
CDZ97361 X.sub.6942 M7 79 2121041 G A
CDZ97380 X.sub.6943 M7 79 2152573 C T
CDZ97392 X.sub.6944 M7 79 2172085 C T
CDZ97397 X.sub.6945 M7 79 2188410 G A
CDZ97405 X.sub.6946 M7 79 2268540 C T
CDZ97435 X.sub.6947 M7 79 2339881 C G
CDZ97460 X.sub.6948 M7 79 2340326 G A
CDZ97462 X.sub.6949 M7 79 2340636 T C
CDZ97462 X.sub.6950 M7 85 512 A G
X.sub.6951 M7 85 516 G A
X.sub.6952 M7 85 521 C T
X.sub.6953 M7 85 522 A G
X.sub.6954 M7 88 119 C T
CDZ97464 X.sub.6955 M7 88 196 G A
CDZ97464 X.sub.6956 M7 88 898 C T
CDZ97464 X.sub.6957 M7 99 245 G A
X.sub.6958 M7 109 396 T C
X.sub.6959 M7 118 396 C T
CDZ97478 X.sub.6960 M7 118 870 G A
CDZ97478 X.sub.6961 M7 118 1491 G A
CDZ97478 X.sub.6962 M7 121 1402 C G
X.sub.6963 M7 124 72117 G A
CDZ97501 X.sub.6964 M7 124 72760 G A
CDZ97501 X.sub.6965 M7 124 94611 G A
CDZ97507 X.sub.6966 M7 124 138045 C T
CDZ97519 X.sub.6967 M7 124 156052 G A
CDZ97524 X.sub.6968 M7 124 166988 C T
CDZ97527 X.sub.6969 M7 124 179336 C T
CDZ97533 X.sub.6970 M7 124 222249 C T
CDZ97547 X.sub.6971 M7 125 35864 T C
CDZ97573 X.sub.6972 M7 129 299 G A
CDZ97577 X.sub.6973 M7 129 433 G A
CDZ97577 X.sub.6974 M7 129 856 G A
CDZ97577 X.sub.6975 M7 129 1013 C T
CDZ97577 X.sub.6976 M7 130 674 C T
CDZ97578 X.sub.6977 M7 138 123 G T
X.sub.6978 M7 141 10162 G A
CDZ97582 X.sub.6979 M7 141 14167 G A
CDZ97586 X.sub.6980 M7 141 15764 C T
CDZ97587 X.sub.6981 M7 141 17894 G A
CDZ97587 X.sub.6982 M7 145 296 A G
X.sub.6983 M7 147 335 C T
X.sub.6984 M7 149 2074 T G
CDZ97598 X.sub.6985 M7 149 2453 C T
CDZ97598 X.sub.6986 M7 159 106 A C
X.sub.6987 M7 162 70025 C T
CDZ97625 X.sub.6988 M7 162 70405 A G
CDZ97625 X.sub.6989 M7 162 91190 C T
CDZ97631 X.sub.6990 M7 162 117736 G A
CDZ97639 X.sub.6991 M7 162 118358 T C
CDZ97641 X.sub.6992 M7 162 207179 C T
CDZ97668 X.sub.6993 M7 162 207236 G A
CDZ97666 X.sub.6994 M7 162 223407 C T
CDZ97674 X.sub.6995 M7 162 230526 C T
CDZ97676 X.sub.6996 M7 162 231146 C T
CDZ97676 X.sub.6997 M7 162 233092 C T
CDZ97676 X.sub.6998 M7 162 243753 G A
CDZ97680 X.sub.6999 M7 162 268123 G A
CDZ97688 X.sub.7000 M7 162 291566 G A
CDZ97695 X.sub.7001 M7 162 308369 T C
CDZ97702 X.sub.7002 M7 162 309562 A G
CDZ97702 X.sub.7003 M7 162 321070 C T
CDZ97703 X.sub.7004 M7 162 321073 A G
CDZ97703 X.sub.7005 M7 162 321460 C G
CDZ97703 X.sub.2006 M7 162 321463 A C
CDZ97703 X.sub.7007 M7 162 321975 T G
CDZ97703 X.sub.7008 M7 162 322591 G A
CDZ97703 X.sub.7009 M7 162 323480 T C
CDZ97703 X.sub.7010 M7 162 324114 T C
CDZ97703 X.sub.7011 M7 162 324139 C T
CDZ97703 X.sub.7012 M7 162 324568 A G
CDZ97703 X.sub.7013 M7 162 360320 G A
CDZ97714 X.sub.7014 M7 162 408274 C T
CDZ97733 X.sub.7015 M7 162 424391 C T
CDZ97740 X.sub.7016 M7 162 444123 T C
CDZ97748 X.sub.7017 M7 162 467207 C T
CDZ97755 X.sub.7018 M7 162 476928 C T
CDZ97760 X.sub.7019 M7 162 491906 G A
CDZ97764 X.sub.7020 M7 162 492101 G A
CDZ97764 X.sub.7021 M7 162 501886 C T
CDZ97769 X.sub.7022 M7 162 581141 C A
CDZ97795 X.sub.7023 M7 162 632311 G A
CDZ97814 X.sub.7024 M7 162 633321 G A
CDZ97814 X.sub.7025 M7 162 633633 G A
CDZ97814 X.sub.7026 M7 162 640005 C T
CDZ97815 X.sub.7027 M7 162 680645 G A
CDZ97826 X.sub.7028 M7 162 721840 G A
CDZ97838 X.sub.7029 M7 162 738675 G A
CDZ97842 X.sub.7030 M7 162 738686 C T
CDZ97842 X.sub.7031 M7 162 801198 C T
CDZ97864 X.sub.7032 M7 162 808830 G A
CDZ97869 X.sub.7033 M7 162 871911 C T
CDZ97890 X.sub.7034 M7 162 946623 C T
CDZ97916 X.sub.7035 M7 162 971882 G A
CDZ97924 X.sub.7036 M7 163 225 G A
X.sub.7037 M7 169 1056 C T
X.sub.7038 M7 189 126573 G A
CDZ97996 X.sub.7039 M7 189 127356 G A
CDZ97996 X.sub.7040 M7 189 174918 G A
CDZ98015 X.sub.7041 M7 189 194647 A G
CDZ98020 X.sub.7042 M7 189 194665 A G
CDZ98020 X.sub.7043 M7 189 211865 C T
CDZ98028 X.sub.7044 M7 189 212408 G A
CDZ98028 X.sub.7045 M7 189 212649 C T
CDZ98028 X.sub.7046 M7 189 273599 C A
CDZ98048 X.sub.7047 M7 189 323680 C T
CDZ98063 X.sub.7048 M7 189 332957 G A
CDZ98065 X.sub.7049 M7 189 371247 G A
CDZ98078 X.sub.7050 M7 191 342 A G
CDZ98107 X.sub.7051 M7 191 347 C T
CDZ98107 X.sub.7052 M7 191 427 C T
CDZ98107 X.sub.7053 M7 191 451 C T
CDZ98107 X.sub.7054 M7 191 487 A G
CDZ98107 X.sub.7055 M7 197 624 C T
CDZ98111 X.sub.7056 M7 198 202 C A
X.sub.7057 M7 198 203 G A
X.sub.7058 M7 198 238 C T
X.sub.7059 M7 198 265 C T
X.sub.7060 M7 199 688 C T
X.sub.7061 M7 199 911 C T
X.sub.7062 M7 199 971 C T
X.sub.7063 M7 199 1218 C T
X.sub.7064 M7 202 171 C T
X.sub.7065 M7 202 221 C T
X.sub.7066 M7 205 360 C T
CDZ98112 X.sub.7067 M7 205 981 C T
CDZ98112 X.sub.7068 M7 206 400 G A
X.sub.7069 M7 208 117 G A
X.sub.7070 M7 208 476 G A
X.sub.7071 M7 208 616 G A
X.sub.7072 M7 208 935 G A
X.sub.7073 M7 209 312 C T
CDZ98113 X.sub.7074 M7 223 93 G A
CDZ98118 X.sub.7075 M7 223 102 A G
CDZ98118 X.sub.7076 M7 223 133 A G
CDZ98118 X.sub.7077 M7 223 150 T C
CDZ98118 X.sub.7078 M7 223 155 A C
CDZ98118 X.sub.7079 M7 223 158 T C
CDZ98118 X.sub.7080 M7 223 160 C T
CDZ98118 X.sub.7081 M7 223 175 G A
CDZ98118 X.sub.7082 M7 223 177 A G
CDZ98118 X.sub.7083 M7 223 188 A G
CDZ98118 X.sub.7084 M7 223 192 C A
CDZ98118 X.sub.7085 M7 223 194 T C
CDZ98118 X.sub.7086 M7 223 195 T G
CDZ98118 X.sub.7087 M7 223 197 T C
CDZ98118 X.sub.7088 M7 223 202 G C
CDZ98118 X.sub.7089 M7 223 205 C T
CDZ98118 X.sub.7090 M7 225 317 C T
X.sub.7091 M7 227 202 G A
X.sub.7092 M7 232 340 G A
CDZ98119 X.sub.7093 M7 232 415 G A
CDZ98119 X.sub.7094 M7 232 1379 C T
CDZ98119 X.sub.7095 M7 232 1521 C T
CDZ98119 X.sub.7096 M7 232 1662 G A
CDZ98119 X.sub.7097 M7 232 1761 C T
CDZ98119 X.sub.7098 M7 232 2027 C T
CDZ98119 X.sub.7099 M7 232 2028 C T
CDZ98119 X.sub.7100 M7 232 3060 C T
CDZ98120 X.sub.7101 M7 232 3284 C T
CDZ98119 X.sub.7102 M7 232 4437 G A
CDZ98121 X.sub.7103 M7 232 4561 C T
CDZ98120 X.sub.7104 M7 242 7334 C T
CDZ98125 X.sub.7105 M7 242 41710 G A
CDZ98131 X.sub.7106 M7 242 50262 G A
CDZ98135 X.sub.7107 M7 242 84132 G A
CDZ98146 X.sub.7108 M7 242 88037 G A
CDZ98147 X.sub.7109 M7 242 106805 G A
CDZ98152 X.sub.7110 M7 242 107587 G A
CDZ98153 X.sub.7111 M7 242 125424 C T
CDZ98159 X.sub.7112 M7 242 168689 G A
CDZ98172 X.sub.7113 M7 242 213986 G A
CDZ98185 X.sub.7114 M7 242 227271 C T
CDZ98191 X.sub.7115 M7 242 233088 G A
CDZ98193 X.sub.7116 M7 242 310353 G A
CDZ98216 X.sub.7117 M7 242 374897 G A
CDZ98238 X.sub.7118 M7 242 404132 G A
CDZ98248 X.sub.7119 M7 242 412676 G A
CDZ98249 X.sub.7120 M7 242 454709 C T
CDZ98263 X.sub.7121 M7 242 472562 C T
CDZ98266 X.sub.7122 M7 242 485936 G A
CDZ98270 X.sub.7123 M7 242 492389 G A
CDZ98274 X.sub.7124 M7 242 514780 C T
CDZ98282 X.sub.7125 M7 242 528340 G A
CDZ98288 X.sub.7126 M7 242 542663 G A
CDZ98290 X.sub.7127 M7 242 559999 G A
CDZ98297 X.sub.7128 M7 242 602456 G A
CDZ98308 X.sub.7129 M7 242 602531 G A
CDZ98308 X.sub.7130 M7 242 603042 G A
CDZ98308 X.sub.7131 M7 242 604704 C T
CDZ98309 X.sub.7132 M7 242 628488 G A
CDZ98317 X.sub.7133 M7 242 641669 G A
CDZ98323 X.sub.7134 M7 249 206 G A
CED84929 X.sub.7135 M7 249 42295 C T
CED84942 X.sub.7136 M7 249 52397 G A
CED84947 X.sub.7137 M7 249 72016 C T
CED84950 X.sub.7138 M7 249 141163 A G
CED84977 X.sub.7139 M7 249 157550 C T
CED84983 X.sub.7140 M7 249 191304 C T
CED84988 X.sub.7141 M7 249 269707 G A
CED85013 X.sub.7142 M7 249 272075 C T
CED85013 X.sub.7143 M7 249 285231 C T
CED85015 X.sub.7144 M7 249 289154 C T
CED85018 X.sub.7145 M7 249 305975 G A
CED85023 X.sub.7146 M7 249 342990 G A
CED85036 X.sub.7147 M7 249 377814 G A
CED85051 X.sub.7148 M7 249 390024 G A
CED85059 X.sub.7149 M7 249 434431 G A
CED85072 X.sub.7150 M7 249 485782 C T
CED85089 X.sub.7151 M7 249 488584 G A
CED85091 X.sub.7152 M7 249 501310 C T
CED85093 X.sub.7153 M7 249 506067 A G
CED85094 X.sub.7154 M7 249 509901 C T
CED85096 X.sub.7155 M7 249 532943 A G
CED85099 X.sub.7156 M7 249 574798 C T
CED85117 X.sub.7157 M7 249 598579 C T
CED85125 X.sub.7158 M7 249 626627 G A
CED85132 X.sub.7159 M7 249 637944 G A
CED85135 X.sub.7160 M7 249 660408 G A
CED85144 X.sub.7161 M7 249 665383 G A
CED85144 X.sub.7162 M7 249 683254 T C
CED85153 X.sub.7163 M7 249 728713 T C
CED85167 X.sub.7164 M7 249 746655 C T
CED85172 X.sub.7165 M7 249 751427 G A
CED85174 X.sub.7166 M7 249 803215 C T
CED85186 X.sub.7167 M7 249 823733 C T
CED85193 X.sub.7168 M7 249 854220 G A
CED85201 X.sub.7169 M7 249 911274 C T
CED85218 X.sub.7170 M7 249 932606 C T
CED85223 X.sub.7171 M7 249 945434 C T
CED85227 X.sub.7172 M7 249 945727 C T
CED85227 X.sub.7173 M7 249 953534 A T
CED85229 X.sub.7174 M7 249 969333 G T
CED85238 X.sub.7175 M7 249 977170 C T
CED85242 X.sub.7176 M7 249 989520 C T
CED85243 X.sub.7177 M7 249 1014098 C T
CED85252 X.sub.7178 M7 249 1058697 C T
CED85263 X.sub.7179 M7 249 1075522 G A
CED85270 X.sub.7180 M7 249 1114790 G A
CED85283 X.sub.7181 M7 249 1144309 G A
CED85291 X.sub.7182 M7 249 1176977 G A
CED85303 X.sub.7183 M7 249 1195367 G A
CED85307 X.sub.7184 M7 249 1209489 C T
CED85313 X.sub.7185 M7 249 1230068 C T
CED85319 X.sub.7186 M7 249 1245242 G A
CED85322 X.sub.7187 M7 249 1299472 C T
CED85343 X.sub.7188 M7 249 1305184 G A
CED85345 X.sub.7189 M7 249 1350079 G A
CED85357 X.sub.7190 M7 249 1391343 G A
CED85372 X.sub.7191 M7 249 1452855 C T
CED85396 X.sub.7192 M7 249 1486813 A C
CED85411 X.sub.7193 M7 249 1486828 G A
CED85411 X.sub.7194 M7 249 1486831 T C
CED85411 X.sub.7195 M7 249 1498029 T C
CED85415 X.sub.7196 M7 249 1498823 T C
CED85414 X.sub.7197 M7 249 1498829 C T
CED85414 X.sub.7198 M7 249 1499357 T G
CED85415 X.sub.7199 M7 249 1499741 G A
CED85415 X.sub.7200 M7 249 1502631 G T
CED85416 X.sub.7201 M7 249 1502641 T A
CED85416 X.sub.7202 M7 249 1502819 T G
CED85416 X.sub.7203 M7 249 1505138 G A
CED85416 X.sub.7204 M7 249 1518591 T A
CED85419 X.sub.7205 M7 249 1519431 A G
CED85419 X.sub.7206 M7 249 1553019 G A
CED85427 X.sub.7207 M7 249 1599808 C T
CED85444 X.sub.7208 M7 249 1599907 C T
CED85444 X.sub.7209 M7 249 1619036 G A
CED85450 X.sub.7210 M7 249 1621516 G A
CED85451 X.sub.7211 M7 249 1623151 G A
CED85451 X.sub.7212 M7 249 1636931 G A
CED85455 X.sub.7213 M7 249 1643086 T A
CED85456 X.sub.7214 M7 249 1653615 T G
CED85457 X.sub.7215 M7 249 1662746 A T
CED85459 X.sub.7216 M7 249 1666185 C T
CED85460 X.sub.7217 M7 249 1679615 G A
CED85461 X.sub.7218 M7 249 1726777 C T
CED85474 X.sub.7219 M7 249 1737431 C T
CED85478 X.sub.7220 M7 249 1741408 C T
CED85480 X.sub.7221 M7 249 1760715 C T
CED85489 X.sub.7222 M7 249 1768844 C T
CED85489 X.sub.7223 M7 249 1780551 A G
CED85493 X.sub.7224 M7 249 1780569 A G
CED85493 X.sub.7225 M7 249 1786050 C T
CED85496 X.sub.7226 M7 249 1803575 C T
CED85502 X.sub.7227 M7 249 1862072 C T
CED85520 X.sub.7228 M7 249 1880762 G A
CED85525 X.sub.7229 M7 249 1944026 G A
CED85545 X.sub.7230 M7 249 1969421 G A
CED85550 X.sub.7231 M7 249 1988505 C T
CED85560 X.sub.7232 M7 249 2010712 G A
CED85564 X.sub.7233 M7 249 2015272 G A
CED85567 X.sub.7234 M7 249 2027477 G A
CED85573 X.sub.7235 M7 249 2054064 C T
CED85583 X.sub.7236 M7 249 2063467 G A
CED85586 X.sub.7237 M7 249 2080239 G A
CED85590 X.sub.7238 M7 249 2110956 C T
CED85603 X.sub.7239 M7 249 2124517 C T
CED85607 X.sub.7240 M7 249 2131353 C T
CED85609 X.sub.7241 M7 249 2167664 G A
CED85620 X.sub.7242 M7 249 2178506 G A
CED85622 X.sub.7243 M7 249 2183695 G A
CED85623 X.sub.7244 M7 249 2198205 G A
CED85628 X.sub.7245 M7 249 2223626 G A
CED85633 X.sub.7246 M7 249 2255547 G C
CED85640 X.sub.7247 M7 252 512 C T
X.sub.7248 M7 252 524 C T
X.sub.7249 M7 258 267 G A
X.sub.7250 M7 258 1139 A T
X.sub.7251 M7 259 91 G C
X.sub.7252 M7 260 156 G A
X.sub.7253 M7 262 4049 G A
CDZ98330 X.sub.7254 M7 262 12289 C T
CDZ98333 X.sub.7255 M7 262 16863 C T
CDZ98334 X.sub.7256 M7 262 30347 G A
CDZ98338 X.sub.7257 M7 262 30359 G A
CDZ98338 X.sub.7258 M7 262 39621 C T
CDZ98342 X.sub.7259 M7 262 96076 C T
CDZ98364 X.sub.7260 M7 262 138889 C T
CDZ98375 X.sub.7261 M7 262 143387 C T
CDZ98375 X.sub.7262 M7 262 144566 G A
CDZ98375 X.sub.7263 M7 262 148151 C T
CDZ98375 X.sub.7264 M7 262 164438 G A
CDZ98383 X.sub.7265 M7 262 201531 G A
CDZ98396 X.sub.7266 M7 262 250756 A G
CDZ98412 X.sub.7267 M7 262 252708 G A
CDZ98414 X.sub.7268 M7 262 319302 G A
CDZ98436 X.sub.7269 M7 262 345538 C T
CDZ98448 X.sub.7270 M7 262 380519 C T
CDZ98457 X.sub.7271 M7 262 383215 C T
CDZ98459 X.sub.7272 M7 262 392930 C T
CDZ98461 X.sub.7273 M7 262 397539 G A
CDZ98463 X.sub.7274 M7 262 410688 C T
CDZ98466 X.sub.7275 M7 262 415802 C T
CDZ98467 X.sub.7276 M7 262 420102 G A
CDZ98468 X.sub.7277 M7 262 444331 G A
CDZ98477 X.sub.7278 M7 262 446956 C T
CDZ98477 X.sub.7279 M7 262 460607 C A
CDZ98482 X.sub.7280 M7 262 503840 G A
CDZ98499 X.sub.7281 M7 262 539428 G A
CDZ98514 X.sub.7282 M7 262 539452 A G
CDZ98514 X.sub.7283 M7 262 539470 A G
CDZ98514 X.sub.7284 M7 262 557280 G A
CDZ98518 X.sub.7285 M7 262 560713 G A
CDZ98519 X.sub.7286 M7 262 562795 C T
CDZ98521 X.sub.7287 M7 262 567591 G A
CDZ98524 X.sub.7288 M7 262 567801 G A
CDZ98524 X.sub.7289 M7 262 577776 C T
CDZ98526 X.sub.7290 M7 262 607661 G A
CDZ98533 X.sub.7291 M7 262 618198 G A
CDZ98538 X.sub.7292 M7 262 639869 G C
CDZ98544 X.sub.7293 M7 262 639962 A G
CDZ98544 X.sub.7294 M7 262 640066 A G
CDZ98544 X.sub.7295 M7 262 640111 A G
CDZ98544 X.sub.7296 M7 262 644677 C T
CDZ98544- CDZ98545 X.sub.7297 M7 262 647379 A G
CDZ98544- CDZ98545 X.sub.7298 M7 262 647388 T C
CDZ98544- CDZ98545 X.sub.7299 M7 262 647393 G A
CDZ98544- CDZ98545 X.sub.7300 M7 262 647394 A G
CDZ98544- CDZ98545 X.sub.7301 M7 262 647430 C T
CDZ98544- CDZ98545 X.sub.7302 M7 262 647433 A G
CDZ98544- CDZ98545 X.sub.7303 M7 262 653920 A G
CDZ98545 X.sub.7304 M7 262 656031 C A
CDZ98545 X.sub.7305 M7 262 656323 C G
CDZ98545 X.sub.7306 M7 262 668764 C T
CDZ98545 X.sub.7307 M7 262 669984 C T
CDZ98547 X.sub.7308 M7 262 691577 C T
CDZ98551 X.sub.7309 M7 262 759057 C A
CDZ98575 X.sub.7310 M7 262 759058 A C
CDZ98575 X.sub.7311 M7 262 801565 G A
CDZ98589 X.sub.7312 M7 262 822734 G A
CDZ98597 X.sub.7313 M7 262 835874 C T
CDZ98601 X.sub.7314 M7 262 856616 G A
CDZ98612 X.sub.7315 M7 262 865999 G A
CDZ98613 X.sub.7316 M7 262 882258 G A
CDZ98619 X.sub.7317 M7 262 971713 G A
CDZ98649 X.sub.7318 M7 262 1008174 C T
CDZ98659 X.sub.7319 M7 262 1021485 C T
CDZ98663 X.sub.7320 M7 262 1080137 G A
CDZ98679 X.sub.7321 M7 262 1120617 G A
CDZ98696 X.sub.7322 M7 262 1204782 G A
CDZ98722 X.sub.7323 M7 262 1209662 G A
CDZ98723 X.sub.7324 M7 262 1226072 C T
CDZ98730 X.sub.7325 M7 262 1229407 G A
CDZ98732 X.sub.7326 M7 262 1277604 G A
CDZ98747 X.sub.7327 M7 262 1305361 G A
CDZ98753 X.sub.7328 M7 262 1329643 C T
CDZ98760 X.sub.7329 M7 262 1332176 C T
CDZ98761 X.sub.7330 M7 262 1349561 G A
CDZ98766 X.sub.7331 M7 262 1351116 A G
CDZ98766 X.sub.7332 M7 262 1367361 C T
CDZ98772 X.sub.7333 M7 262 1408928 G A
CDZ98786 X.sub.7334 M7 262 1416604 C T
CDZ98788 X.sub.7335 M7 262 1424293 G A
CDZ98791 X.sub.7336 M7 262 1455677 G A
CDZ98804 X.sub.7337 M7 262 1458863 C T
CDZ98807 X.sub.7338 M7 262 1550311 C T
CDZ98836 X.sub.7339 M7 262 1550456 C T
CDZ98837 X.sub.7340 M7 262 1615762 G A
CDZ98855 X.sub.7341 M7 262 1677620 G A
CDZ98873 X.sub.7342 M7 262 1694625 C T
CDZ98878 X.sub.7343 M7 262 1704629 T C
CDZ98883 X.sub.7344 M7 262 1706076 G A
CDZ98885 X.sub.7345 M7 262 1709988 G A
CDZ98884 X.sub.7346 M7 262 1711527 G A
CDZ98886 X.sub.7347 M7 262 1716385 G A
CDZ98887 X.sub.7348 M7 266 252 C T
X.sub.7349 M7 267 93 G A
X.sub.7350 M7 267 94 A G
X.sub.7351 M7 267 133 T C
X.sub.7352 M7 267 134 C T
X.sub.7353 M7 267 201 T C
X.sub.7354 M7 267 208 T C
X.sub.7355 M7 267 234 T C
X.sub.7356 M7 267 254 G T
X.sub.7357 M7 267 256 A G
X.sub.7358 M7 267 257 T C
X.sub.7359 M8 22 1643 C T
CED80056 X.sub.7360 M8 22 2524 G A
CED80056 X.sub.7361 M8 28 236 G A
CDZ96150 X.sub.7362 M8 28 377 G A
CDZ96150 X.sub.7363 M8 28 1506995 C T
CDZ96150 X.sub.7364 M8 28 1677 C T
CDZ96150 X.sub.7365 M8 43 464 G A
CDZ96151 X.sub.7366 M8 43 753 C T
CDZ96151 X.sub.7367 M8 43 757 G A
CDZ96151 X.sub.7368 M8 43 1527 C T
CDZ96151 X.sub.7369 M8 43 1748 G A
CDZ96151 X.sub.7370 M8 43 1928 C T
CDZ96151 X.sub.7371 M8 62 26 T A
CDZ96152 X.sub.7372 M8 62 27 T C
CDZ96152 X.sub.7373 M8 62 55 T A
CDZ96152 X.sub.7374 M8 62 403 C T
CDZ96152 X.sub.7375 M8 62 875 G A
CDZ96152 X.sub.7376 M8 102 339 C T
CDZ96153 X.sub.7377 M8 102 951 G A
CDZ96153 X.sub.7378 M8 102 1042 G A
CDZ96153 X.sub.7379 M8 102 2334 G A
CDZ96153 X.sub.7380 M8 102 2590 C T
CDZ96153 X.sub.7381 M8 102 3427 C T
CDZ96153 X.sub.7382 M8 176 358 G A
CED80058 X.sub.7383 M8 176 1872 G A
CED80058 X.sub.7384 M8 176 1980 G A
CED80058 X.sub.7385 M8 179 1525 G A
CDZ96154 X.sub.7386 M8 179 1780 C T
CDZ96154 X.sub.7387 M8 179 2472 G A
CDZ96154 X.sub.7388 M8 179 2476 C T
CDZ96154 X.sub.7389 M8 188 815 C T
CED80060 X.sub.7390 M8 188 1174 C T
CED80060 X.sub.7391 M8 188 2163 G A
CED80060 X.sub.7392 M8 188 2170 G A
CED80060 X.sub.7393 M8 247 102 G A
CED80061 X.sub.7394 M8 247 989 C T
CED80061 X.sub.7395 M8 247 1053 G A
CED80061 X.sub.7396 M8 3 142 C T
X.sub.7397 M8 7 160 T C
X.sub.7398 M8 8 1110 C T
X.sub.7399 M8 11 154 A C
X.sub.7400 M8 11 158 C T
X.sub.7401 M8 15 28 C G
X.sub.7402 M8 15 214 G C
X.sub.7403 M8 15 419 A G
X.sub.7404 M8 15 421 G T
X.sub.7405 M8 15 422 G T
X.sub.7406 M8 15 424 G C
X.sub.7407 M8 15 431 G C
X.sub.7408 M8 15 433 C A
X.sub.7409 M8 15 434 C A
X.sub.7410 M8 15 462 C T
X.sub.7411 M8 15 464 C A
X.sub.7412 M8 15 465 C T
X.sub.7413 M8 24 513 T C
CDZ96160 X.sub.7414 M8 24 520 C G
CDZ96160 X.sub.7415 M8 24 5850 C T
CDZ96160 X.sub.7416 M8 24 118860 C T
CDZ96200 X.sub.7417 M8 24 180340 G A
CDZ96216 X.sub.7418 M8 24 266697 G A
CDZ96242 X.sub.7419 M8 24 307114 G A
CDZ96255 X.sub.7420 M8 24 335171 C T
CDZ96265 X.sub.7421 M8 24 340663 T C
CDZ96265 X.sub.7422 M8 24 349340 C T
CDZ96270 X.sub.7423 M8 24 349352 G A
CDZ96270 X.sub.7424 M8 24 363770 C T
CDZ96275 X.sub.7425 M8 24 420108 G A
CDZ96291 X.sub.7426 M8 24 422035 G A
CDZ96291 X.sub.7427 M8 24 484490 C T
CDZ96313 X.sub.7428 M8 27 445 C T
X.sub.7429 M8 27 1012 A C
X.sub.7430 M8 27 1013 T A
X.sub.7431 M8 32 158 C T
CDZ96332 X.sub.7432 M8 32 215 C T
CDZ96332 X.sub.7433 M8 32 2438 C T
CDZ96332 X.sub.7434 M8 32 2734 C T
CDZ96332 X.sub.7435 M8 32 2821 C T
CDZ96332 X.sub.7436 M8 32 3067 C T
CDZ96332 X.sub.7437 M8 32 3506 C T
CDZ96332 X.sub.7438 M8 32 3562 G A
CDZ96332 X.sub.7439 M8 33 399 T A
CED82002 X.sub.7440 M8 33 24784 C T
CED82008 X.sub.7441 M8 33 45488 C T
CED82012 X.sub.7442 M8 33 64676 G A
CED82019 X.sub.7443 M8 33 79913 G A
CED82024 X.sub.7444 M8 33 109397 G A
CED82038 X.sub.7445 M8 33 182417 G A
CED82062 X.sub.7446 M8 33 198050 C T
CED82067 X.sub.7447 M8 33 257786 C T
CED82084 X.sub.7448 M8 33 260027 G A
CED82084 X.sub.7449 M8 33 274627 G A
CED82091 X.sub.7450 M8 33 276128 C T
CED82092 X.sub.7451 M8 33 283808 C T
CED82093 X.sub.7452 M8 33 318242 G A
CED82105 X.sub.7453 M8 33 326016 T C
CED82108 X.sub.7454 M8 33 327840 C T
CED82108 X.sub.7455 M8 33 341890 G A
CED82113 X.sub.7456 M8 33 374131 A G
CED82121- CED82122 X.sub.7457 M8 33 374134 A G
CED82121- CED82122 X.sub.7458 M8 33 374137 A T
CED82121- CED82122 X.sub.7459 M8 33 374150 A C
CED82121- CED82122 X.sub.7460 M8 33 375339 A G
CED82121- CED82122 X.sub.7461 M8 33 375366 T C
CED82121- CED82122 X.sub.7462 M8 33 385139 G C
CED82122 X.sub.7463 M8 33 385155 T C
CED82122 X.sub.7464 M8 33 385319 A C
CED82122 X.sub.7465 M8 33 385527 C T
CED82122 X.sub.7466 M8 33 386116 G C
CED82124 X.sub.7467 M8 33 428329 G A
CED82136 X.sub.7468 M8 33 448815 G A
CED82144 X.sub.7469 M8 33 453975 C T
CED82147 X.sub.7470 M8 33 455451 C T
CED82146 X.sub.7471 M8 33 476006 A G
CED82153 X.sub.7472 M8 33 481361 G A
CED82157 X.sub.7473 M8 33 509127 C T
CED82166 X.sub.7474 M8 33 628247 C T
CED82205 X.sub.7475 M8 33 639242 G A
CED82208 X.sub.7476 M8 33 652012 G A
CED82212 X.sub.7477 M8 33 699423 C T
CED82227 X.sub.7478 M8 33 715901 C T
CED82231 X.sub.7479 M8 33 729705 C T
CED82234 X.sub.7480 M8 33 750883 T C
CED82240 X.sub.7481 M8 33 816048 C T
CED82262 X.sub.7482 M8 33 822184 G A
CED82264 X.sub.7483 M8 33 829825 C T
CED82271 X.sub.7484 M8 33 917771 A T
CED82294 X.sub.7485 M8 33 936571 A G
CED82300 X.sub.7486 M8 33 936600 G A
CED82300 X.sub.7487 M8 33 936667 A G
CED82300 X.sub.7488 M8 33 938634 A G
CED82300 X.sub.7489 M8 33 947993 T A
CED82302 X.sub.7490 M8 33 972701 C T
CED82309 X.sub.7491 M8 33 1049699 G A
CED82334 X.sub.7492 M8 33 1087834 G A
CED82350 X.sub.7493 M8 33 1088320 C T
CED82349 X.sub.7494 M8 33 1127676 G A
CED82358 X.sub.7495 M8 33 1138444 C T
CED82363 X.sub.7496 M8 33 1165914 G A
CED82372 X.sub.7497 M8 33 1191727 C T
CED82379 X.sub.7498 M8 33 1311181 G A
CED82413 X.sub.7499 M8 33 1316789 C T
CED82415 X.sub.7500 M8 33 1324395 G A
CED82417 X.sub.7501 M8 33 1339376 C T
CED82424 X.sub.7502 M8 33 1349009 C T
CED82427 X.sub.7503 M8 33 1367015 C T
CED82432 X.sub.7504 M8 33 1411059 C T
CED82446 X.sub.7505 M8 33 1460436 C T
CED82462 X.sub.7506 M8 33 1499347 G A
CED82472 X.sub.7507 M8 33 1507482 A G
CED82477 X.sub.7508 M8 33 1514686 C T
CED82478 X.sub.7509 M8 33 1515148 G A
CED82478 X.sub.7510 M8 33 1537835 G A
CED82483 X.sub.7511 M8 33 1544767 A C
CED82485- CED82486 X.sub.7512 M8 33 1585699 C T
CED82497 X.sub.7513 M8 33 1587443 C T
CED82497 X.sub.7514 M8 33 1596242 C T
CED82498 X.sub.7515 M8 33 1638726 G A
CED82513 X.sub.7516 M8 33 1642659 G A
CED82515 X.sub.7517 M8 33 1651969 A T
CED82517 X.sub.7518 M8 33 1689192 C T
CED82529 X.sub.7519 M8 33 1700000 G A
CED82534 X.sub.7520 M8 33 1716261 C T
CED82538 X.sub.7521 M8 33 1728730 G A
CED82541 X.sub.7522 M8 33 1740595 C T
CED82545 X.sub.7523 M8 33 1745517 C T
CED82546 X.sub.7524 M8 33 1780044 G A
CED82555 X.sub.7525 M8 33 1838447 G A
CED82575 X.sub.7526 M8 33 1841263 G A
CED82576 X.sub.7527 M8 33 1848935 C T
CED82579 X.sub.7528 M8 33 1860991 G A
CED82583 X.sub.7529 M8 33 1887401 C T
CED82591 X.sub.7530 M8 33 1905896 G A
CED82599 X.sub.7531 M8 33 1959142 G A
CED82619 X.sub.7532 M8 33 1967112 C T
CED82622 X.sub.7533 M8 33 2010230 C T
CED82636 X.sub.7534 M8 33 2034962 G A
CED82645 X.sub.7535 M8 33 2046185 C T
CED82650 X.sub.7536 M8 36 320 G A
X.sub.7537 M8 36 1056 G A
X.sub.7538 M8 36 1295 C T
X.sub.7539 M8 36 1461 A T
X.sub.7540 M8 42 804 C T
CDZ96333 X.sub.7541 M8 42 1559 G A
CDZ96333 X.sub.7542 M8 48 563 C T
X.sub.7543 M8 48 565 T C
X.sub.7544 M8 48 576 G A
X.sub.7545 M8 48 580 T A
X.sub.7546 M8 48 720 A G
X.sub.7547 M8 50 145 G A
X.sub.7548 M8 52 123705 C T
CED82700 X.sub.7549 M8 52 144382 C T
CED82709 X.sub.7550 M8 52 145060 G A
CED82708 X.sub.7551 M8 52 151974 C T
CED82712 X.sub.7552 M8 52 183986 C T
CED82722 X.sub.7553 M8 52 207354 C T
CED82730 X.sub.7554 M8 52 240241 T C
CED82734 X.sub.7555 M8 52 243203 G A
CED82733 X.sub.7556 M8 52 244305 G A
CED82734 X.sub.7557 M8 52 284733 G A
CED82747 X.sub.7558 M8 52 344346 G A
CED82767 X.sub.7559 M8 52 358601 G A
CED82772 X.sub.7560 M8 52 360279 C T
CED82772 X.sub.7561 M8 52 390095 G A
CED82784 X.sub.7562 M8 52 390988 C T
CED82785 X.sub.7563 M8 52 395374 G A
CED82786 X.sub.7564 M8 52 398723 C T
CED82786 X.sub.7565 M8 52 398728 C T
CED82786 X.sub.7566 M8 52 473123 G A
CED82810 X.sub.7567 M8 52 487472 C T
CED82814 X.sub.7568 M8 52 516267 C T
CED82823 X.sub.7569 M8 52 542542 C T
CED82833 X.sub.7570 M8 52 552099 G A
CED82837 X.sub.7571 M8 52 552173 G A
CED82837 X.sub.7572 M8 52 553027 G A
CED82837 X.sub.7573 M8 52 557092 C T
CED82840 X.sub.7574 M8 52 631479 C T
CED82860 X.sub.7575 M8 52 697002 C T
CED82888 X.sub.7576 M8 52 700204 G A
CED82888 X.sub.7577 M8 52 710492 C T
CED82891 X.sub.7578 M8 52 725138 C T
CED82899 X.sub.7579 M8 52 741861 G A
CED82905 X.sub.7580 M8 52 746548 G A
CED82907 X.sub.7581 M8 52 783981 C T
CED82919 X.sub.7582 M8 52 817452 T A
CED82928 X.sub.7583 M8 52 819924 C T
CED82929 X.sub.7584 M8 52 840755 C T
CED82935 X.sub.7585 M8 52 849671 G A
CED82940 X.sub.7586 M8 52 928854 C T
CED82971 X.sub.7587 M8 52 938650 G A
CED82973 X.sub.7588 M8 52 967316 A T
CED82984 X.sub.7589 M8 52 967701 T A
CED82983 X.sub.7590 M8 52 1003899 G A
CED83001 X.sub.7591 M8 52 1009554 C T
CED83003 X.sub.7592 M8 52 1010007 C T
CED83002 X.sub.7593 M8 52 1020804 G A
CED83005 X.sub.7594 M8 52 1021202 C T
CED83005 X.sub.7595 M8 52 1029498 G A
CED83007 X.sub.7596 M8 52 1043011 C T
CED83012 X.sub.7597 M8 52 1067895 C T
CED83020 X.sub.7598 M8 52 1158103 C T
CED83051 X.sub.7599 M8 52 1163067 G A
CED83051 X.sub.7600 M8 52 1227910 G A
CED83074 X.sub.7601 M8 52 1297876 G A
CED83099 X.sub.7602 M8 52 1336560 G A
CED83113 X.sub.7603 M8 52 1350463 C T
CED83118 X.sub.7604 M8 52 1356590 C T
CED83120 X.sub.7605 M8 52 1362217 C T
CED83122 X.sub.7606 M8 52 1363357 G A
CED83122 X.sub.7607 M8 52 1363405 C T
CED83123 X.sub.7608 M8 52 1365822 C T
CED83124 X.sub.7609 M8 52 1392238 C T
CED83130 X.sub.7610 M8 52 1399439 G A
CED83134 X.sub.7611 M8 52 1458571 C T
CED83158 X.sub.7612 M8 52 1475408 C T
CED83166 X.sub.7613 M8 52 1525824 G T
CED83180 X.sub.7614 M8 52 1526796 G A
CED83181 X.sub.7615 M8 52 1540879 C T
CED83186 X.sub.7616 M8 52 1583655 C T
CED83206 X.sub.7617 M8 52 1621166 C T
CED83219 X.sub.7618 M8 52 1700952 G A
CED83246 X.sub.7619 M8 52 1708900 A G
CED83249 X.sub.7620 M8 52 1715136 C T
CED83250 X.sub.7621 M8 52 1715899 C T
CED83250 X.sub.7622 M8 52 1716210 C T
CED83250 X.sub.7623 M8 52 1760440 G A
CED83266 X.sub.7624 M8 52 1765533 G A
CED83268 X.sub.7625 M8 52 1787135 C T
CED83275 X.sub.7626 M8 52 1793370 G A
CED83275 X.sub.7627 M8 52 1796780 G A
CED83279 X.sub.7628 M8 52 1807309 G A
CED83283 X.sub.7629 M8 52 1864608 G A
CED83303 X.sub.7630 M8 52 1871310 C T
CED83304 X.sub.7631 M8 52 1874150 G T
CED83305 X.sub.7632 M8 52 1874531 C T
CED83306 X.sub.7633 M8 52 1888989 C T
CED83312 X.sub.7634 M8 52 1892615 C T
CED83313 X.sub.7635 M8 52 1915927 G A
CED83315 X.sub.7636 M8 52 1938393 C T
CED83322 X.sub.7637 M8 52 1956479 C T
CED83330 X.sub.7638 M8 52 1987096 G A
CED83341 X.sub.7639 M8 52 2041781 C T
CED83355 X.sub.7640 M8 52 2047954 G A
CED83358 X.sub.7641 M8 52 2050245 G A
CED83359 X.sub.7642 M8 52 2071127 C T
CED83365 X.sub.7643 M8 52 2081390 G A
CED83367 X.sub.7644 M8 52 2093148 C T
CED83368 X.sub.7645 M8 52 2093251 C T
CED83368 X.sub.7646 M8 52 2120665 C T
CED83376 X.sub.7647 M8 52 2136885 A G
CED83382 X.sub.7648 M8 52 2162878 G A
CED83392 X.sub.7649 M8 52 2171271 C T
CED83395 X.sub.7650 M8 52 2258192 C T
CED83422 X.sub.7651 M8 52 2265219 C T
CED83425 X.sub.7652 M8 52 2266378 C T
CED83423 X.sub.7653 M8 52 2296638 G A
CED83432 X.sub.7654 M8 52 2308421 T C
CED83439 X.sub.7655 M8 52 2327266 C T
CED83445 X.sub.7656 M8 52 2400778 C T
CED83463 X.sub.7657 M8 52 2531584 C T
CED83507 X.sub.7658 M8 52 2543220 C T
CED83509 X.sub.7659 M8 52 2549953 A G
CED83516 X.sub.7660 M8 52 2566106 C T
CED83520 X.sub.7661 M8 52 2575090 A G
CED83525 X.sub.7662 M8 53 26291 G A
CDZ96348 X.sub.7663 M8 54 4815 G A
CDZ96384 X.sub.7664 M8 54 4816 A T
CDZ96384 X.sub.7665 M8 54 4817 G C
CDZ96384 X.sub.7666 M8 54 4821 G A
CDZ96384 X.sub.7667 M8 54 16963 C T
CDZ96386 X.sub.7668 M8 54 72235 G A
CDZ96406 X.sub.7669 M8 54 106086 G A
CDZ96416 X.sub.7670 M8 54 119439 C T
CDZ96420 X.sub.7671 M8 54 129380 C T
CDZ96423 X.sub.7672 M8 54 164317 A T
CDZ96437 X.sub.7673 M8 54 194230 G A
CDZ96446 X.sub.7674 M8 54 195804 G A
CDZ96447 X.sub.7675 M8 54 202467 C T
CDZ96448 X.sub.7676 M8 54 206494 G A
CDZ96450 X.sub.7677 M8 54 207267 G A
CDZ96450 X.sub.7678 M8 54 207737 C T
CDZ96450 X.sub.7679 M8 54 245840 G A
CDZ96464 X.sub.7680 M8 54 274617 A T
CDZ96471 X.sub.7681 M8 54 278479 C T
CDZ96474 X.sub.7682 M8 54 303553 T C
CDZ96484 X.sub.7683 M8 54 357141 G A
CDZ96496 X.sub.7684 M8 54 370320 G A
CDZ96499 X.sub.7685 M8 54 391223 A G
CDZ96509 X.sub.7686 M8 54 395454 G A
CDZ96509 X.sub.7687 M8 54 413765 G A
CDZ96516 X.sub.7688 M8 54 427542 C T
CDZ96520 X.sub.7689 M8 54 431404 C T
CDZ96520 X.sub.7690 M8 54 478527 C T
CDZ96537 X.sub.7691 M8 54 537282 T C
CDZ96557 X.sub.7692 M8 54 583996 G A
CDZ96570 X.sub.7693 M8 54 616268 A G
CDZ96581 X.sub.7694 M8 54 631489 G A
CDZ96585 X.sub.7695 M8 54 733193 T C
CDZ96619 X.sub.7696 M8 54 743396 G A
CDZ96621 X.sub.7697 M8 58 93 T C
X.sub.7698 M8 64 2113 G A
CDZ96626 X.sub.7699 M8 65 124 C T
CDZ96627 X.sub.7700 M8 67 111 G A
X.sub.7701 M8 67 176 C T
X.sub.7702 M8 69 19892 T C
CED83533 X.sub.7703 M8 69 19893 G A
CED83533 X.sub.7704 M8 69 20845 C T
CED83532 X.sub.7705 M8 69 29006 G A
CED83534 X.sub.7706 M8 69 48869 G A
CED83542 X.sub.7707 M8 69 52428 G A
CED83541 X.sub.7708 M8 69 55826 G A
CED83545 X.sub.7709 M8 69 82710 G A
CED83554 X.sub.7710 M8 69 107920 C T
CED83561 X.sub.7711 M8 69 148757 C T
CED83575 X.sub.7712 M8 69 179873 C T
CED83585 X.sub.7713 M8 69 196810 G A
CED83594 X.sub.7714 M8 69 201005 G A
CED83595 X.sub.7715 M8 69 201292 G A
CED83595 X.sub.7716 M8 69 312480 A G
CED83633 X.sub.7717 M8 69 371916 C T
CED83653 X.sub.7718 M8 69 384418 G A
CED83656 X.sub.7719 M8 69 386371 C T
CED83657 X.sub.7720 M8 69 415659 C T
CED83665 X.sub.7721 M8 69 431248 G A
CED83671 X.sub.7722 M8 69 461986 G A
CED83680 X.sub.7723 M8 69 523701 C T
CED83701 X.sub.7724 M8 69 534495 C T
CED83704 X.sub.7725 M8 69 585845 G A
CED83722 X.sub.7726 M8 69 631511 G A
CED83742 X.sub.7727 M8 69 637299 T C
CED83744 X.sub.7728 M8 69 638135 G A
CED83744 X.sub.7729 M8 69 675579 G A
CED83760 X.sub.7730 M8 69 676581 G A
CED83760 X.sub.7731 M8 69 676853 G A
CED83759 X.sub.7732 M8 69 678406 C T
CED83759 X.sub.7733 M8 69 682770 C T
CED83763 X.sub.7734 M8 69 741255 C T
CED83781 X.sub.7735 M8 69 761819 C T
CED83789 X.sub.7736 M8 69 777063 G A
CED83792 X.sub.7737 M8 69 859081 C T
CED83813 X.sub.7738 M8 69 865820 C T
CED83814 X.sub.7739 M8 69 869706 G A
CED83815 X.sub.7740 M8 69 892199 G A
CED83822 X.sub.7741 M8 69 894019 G A
CED83821 X.sub.7742 M8 69 894462 C T
CED83821 X.sub.7743 M8 69 930700 C T
CED83835 X.sub.7744 M8 69 971219 C T
CED83847 X.sub.7745 M8 69 988364 G A
CED83857 X.sub.7746 M8 69 989781 G A
CED83858 X.sub.7747 M8 69 994927 C T
CED83859 X.sub.7748 M8 69 1017805 G A
CED83865 X.sub.7749 M8 69 1038140 G A
CED83874 X.sub.7750 M8 69 1072756 G A
CED83886 X.sub.7751 M8 69 1084824 G A
CED83891 X.sub.7752 M8 69 1084835 C T
CED83891 X.sub.7753 M8 69 1084848 A G
CED83891 X.sub.7754 M8 69 1084866 A G
CED83891 X.sub.7755 M8 69 1084931 C T
CED83891 X.sub.7756 M8 69 1102164 C T
CED83897 X.sub.7757 M8 69 1109785 C T
CED83899 X.sub.7758 M8 69 1109813 A G
CED83899 X.sub.7759 M8 69 1109818 A G
CED83899 X.sub.7760 M8 69 1109819 T A
CED83899 X.sub.7761 M8 69 1109823 T C
CED83899 X.sub.7762 M8 69 1109830 A G
CED83899 X.sub.7763 M8 69 1109831 C A
CED83899 X.sub.7764 M8 69 1109835 A G
CED83899 X.sub.7765 M8 69 1143597 C G
CED83911 X.sub.7766 M8 69 1153118 G A
CED83915 X.sub.7767 M8 69 1199155 C T
CED83929 X.sub.7768 M8 69 1218409 G A
CED83936 X.sub.7769 M8 69 1228996 G A
CED83939 X.sub.7770 M8 69 1229023 G A
CED83939 X.sub.7771 M8 69 1245509 C T
CED83943 X.sub.7772 M8 69 1255967 C T
CED83949 X.sub.7773 M8 69 1260087 G A
CED83949 X.sub.7774 M8 69 1285491 T C
CED83961 X.sub.7775 M8 69 1326247 G A
CED83969 X.sub.7776 M8 69 1342909 G A
CED83975 X.sub.7777 M8 69 1372486 C T
CED83987 X.sub.7778 M8 69 1411237 C T
CED84001 X.sub.7779 M8 69 1411421 C T
CED83999 X.sub.7780 M8 69 1412234 G A
CED83999 X.sub.7781 M8 69 1433913 C T
CED84007 X.sub.7782 M8 69 1485040 G A
CED84023 X.sub.7783 M8 69 1529637 C T
CED84038 X.sub.7784 M8 69 1539964 C T
CED84041 X.sub.7785 M8 69 1590302 G A
CED84059 X.sub.7786 M8 69 1601173 C T
CED84062 X.sub.7787 M8 69 1652288 C T
CED84077 X.sub.7788 M8 69 1674261 C T
CED84084 X.sub.7789 M8 69 1678475 C T
CED84085 X.sub.7790 M8 69 1687066 A G
CED84088 X.sub.7791 M8 69 1687394 G A
CED84087 X.sub.7792 M8 69 1688555 C T
CED84088 X.sub.7793 M8 69 1688570 C T
CED84088 X.sub.7794 M8 69 1714728 G A
CED84097 X.sub.7795 M8 69 1735172 G A
CED84108 X.sub.7796 M8 69 1740723 T C
CED84109 X.sub.7797 M8 69 1771849 C T
CED84116 X.sub.7798 M8 69 1784836 C T
CED84123 X.sub.7799 M8 69 1792597 C T
CED84126 X.sub.7800 M8 69 1800584 G A
CED84129 X.sub.7801 M8 69 1854739 G A
CED84145 X.sub.7802 M8 69 1855951 C T
CED84145 X.sub.7803 M8 69 1871563 G A
CED84153 X.sub.7804 M8 69 1924621 C T
CED84172 X.sub.7805 M8 69 1967529 C T
CED84189 X.sub.7806 M8 69 1968848 A G
CED84189 X.sub.7807 M8 69 2001469 C T
CED84197 X.sub.7808 M8 69 2089848 A G
CED84232 X.sub.7809 M8 69 2089870 C T
CED84232 X.sub.7810 M8 69 2089876 C A
CED84232 X.sub.7811 M8 69 2156050 C T
CED84252 X.sub.7812 M8 69 2160207 C T
CED84255 X.sub.7813 M8 69 2213959 C T
CED84269 X.sub.7814 M8 69 2240834 C T
CED84277 X.sub.7815 M8 69 2245069 G A
CED84279 X.sub.7816 M8 69 2264484 G A
CED84284 X.sub.7817 M8 69 2283903 G A
CED84293 X.sub.7818 M8 69 2366082 C T
CED84318 X.sub.7819 M8 69 2438727 C T
CED84343 X.sub.7820 M8 69 2483433 G A
CED84352 X.sub.7821 M8 72 93 T C
X.sub.7822 M8 72 584 G A
X.sub.7823 M8 72 856 C T
X.sub.7824 M8 72 1163 C T
X.sub.7825 M8 73 730 C A
CDZ96628 X.sub.7826 M8 77 18912 A G
CDZ96635 X.sub.7827 M8 77 34978 G T
CDZ96642 X.sub.7828 M8 77 39842 G A
CDZ96646 X.sub.7829 M8 77 84022 G A
CDZ96659 X.sub.7830 M8 77 116691 G A
CDZ96671 X.sub.7831 M8 78 1865 C T
CED84359 X.sub.7832 M8 78 6333 G A
CED84360 X.sub.7833 M8 78 21716 C T
CED84364 X.sub.7834 M8 78 35200 G A
CED84371 X.sub.7835 M8 78 109325 G A
CED84390 X.sub.7836 M8 78 127873 G A
CED84395 X.sub.7837 M8 78 158434 G A
CED84406 X.sub.7838 M8 78 158534 G A
CED84406 X.sub.7839 M8 78 200234 C T
CED84420 X.sub.7840 M8 78 238854 C T
CED84430 X.sub.7841 M8 78 262614 A C
CED84438 X.sub.7842 M8 78 262683 G A
CED84438 X.sub.7843 M8 78 263826 C T
CED84438 X.sub.7844 M8 78 263828 T C
CED84438 X.sub.7845 M8 78 281454 C A
CED84441 X.sub.7846 M8 78 292068 C T
CED84442 X.sub.7847 M8 78 292139 A T
CED84442 X.sub.7848 M8 78 292243 G A
CED84442 X.sub.7849 M8 78 298141 C G
CED84443 X.sub.7850 M8 78 299644 G A
CED84443 X.sub.7851 M8 78 301815 T C
CED84443 X.sub.7852 M8 78 304799 A C
CED84444 X.sub.7853 M8 78 311586 C T
CED84447 X.sub.7854 M8 78 333312 A G
CED84452 X.sub.7855 M8 78 368785 G A
CED84464 X.sub.7856 M8 78 403167 G A
CED84476 X.sub.7857 M8 78 404944 G A
CED84475 X.sub.7858 M8 78 439640 C T
CED84487 X.sub.7859 M8 78 462728 G A
CED84497 X.sub.7860 M8 78 480848 C T
CED84500 X.sub.7861 M8 78 506703 G A
CED84508 X.sub.7862 M8 78 534530 C T
CED84520 X.sub.7863 M8 78 611362 C T
CED84546 X.sub.7864 M8 78 626958 C A
CED84549 X.sub.7865 M8 78 631891 C T
CED84551 X.sub.7866 M8 78 726983 G A
CED84587 X.sub.7867 M8 78 763771 G A
CED84600 X.sub.7868 M8 78 774252 G A
CED84602 X.sub.7869 M8 78 847242 G T
CED84624 X.sub.7870 M8 78 905457 A G
CED84645 X.sub.7871 M8 78 952815 G A
CED84662 X.sub.7872 M8 78 952860 G A
CED84662 X.sub.7873 M8 78 1023381 G A
CED84688 X.sub.7874 M8 78 1086537 C T
CED84713 X.sub.7875 M8 78 1095322 C T
CED84715 X.sub.7876 M8 78 1112587 C T
CED84722 X.sub.7877 M8 78 1115511 G A
CED84723 X.sub.7878 M8 78 1199323 C T
CED84746 X.sub.7879 M8 78 1216573 C T
CED84752 X.sub.7880 M8 78 1247678 C T
CED84761 X.sub.7881 M8 78 1278982 C T
CED84773 X.sub.7882 M8 78 1302286 C T
CED84782 X.sub.7883 M8 78 1317124 G A
CED84787 X.sub.7884 M8 78 1344640 C T
CED84795 X.sub.7885 M8 78 1356873 C T
CED84800 X.sub.7886 M8 78 1376517 G A
CED84810 X.sub.7887 M8 78 1406981 C T
CED84821 X.sub.7888 M8 78 1426722 C T
CED84829 X.sub.7889 M8 78 1475803 G A
CED84845 X.sub.7890 M8 78 1495995 C T
CED84852 X.sub.7891 M8 78 1498179 G A
CED84852 X.sub.7892 M8 78 1520586 C T
CED84855 X.sub.7893 M8 78 1549659 G A
CED84862 X.sub.7894 M8 78 1568326 C T
CED84868 X.sub.7895 M8 78 1578844 G A
CED84871 X.sub.7896 M8 78 1642170 G A
CED84889 X.sub.7897 M8 78 1660408 G A
CED84897 X.sub.7898 M8 78 1694684 C T
CED84912 X.sub.7899 M8 78 1742796 G A
CED84926 X.sub.7900 M8 79 161 T C
CDZ96674 X.sub.7901 M8 79 6477 T C
CDZ96674- CDZ96675 X.sub.7902 M8 79 37870 T C
CDZ96683 X.sub.7903 M8 79 47085 G A
CDZ96684 X.sub.7904 M8 79 57804 G A
CDZ96687 X.sub.7905 M8 79 64658 C T
CDZ96688 X.sub.7906 M8 79 132683 C T
CDZ96713 X.sub.7907 M8 79 168570 C T
CDZ96727 X.sub.7908 M8 79 255486 C T
CDZ96758 X.sub.7909 M8 79 255780 G A
CDZ96757 X.sub.7910 M8 79 307021 C T
CDZ96777 X.sub.7911 M8 79 318883 G A
CDZ96779 X.sub.7912 M8 79 346823 G A
CDZ96789 X.sub.7913 M8 79 406184 G A
CDZ96808 X.sub.7914 M8 79 409085 C T
CDZ96810 X.sub.7915 M8 79 484404 C T
CDZ96840 X.sub.7916 M8 79 492523 C T
CDZ96842 X.sub.7917 M8 79 526910 C T
CDZ96854 X.sub.7918 M8 79 552798 C T
CDZ96861 X.sub.7919 M8 79 570874 C T
CDZ96867 X.sub.7920 M8 79 575411 C T
CDZ96868 X.sub.7921 M8 79 579674 G A
CDZ96871 X.sub.7922 M8 79 617057 C T
CDZ96882 X.sub.7923 M8 79 679140 C T
CDZ96904 X.sub.7924 M8 79 683546 T C
CDZ96904 X.sub.7925 M8 79 683550 A G
CDZ96904 X.sub.7926 M8 79 691309 C T
CDZ96911 X.sub.7927 M8 79 696174 G A
CDZ96911 X.sub.7928 M8 79 710422 G A
CDZ96916 X.sub.7929 M8 79 735053 T C
CDZ96928 X.sub.7930 M8 79 758025 G A
CDZ96931 X.sub.7931 M8 79 758078 T C
CDZ96931 X.sub.7932 M8 79 759403 C T
CDZ96931 X.sub.7933 M8 79 759589 G A
CDZ96932 X.sub.7934 M8 79 759659 G A
CDZ96931 X.sub.7935 M8 79 760430 T C
CDZ96932 X.sub.7936 M8 79 760541 A G
CDZ96932 X.sub.7937 M8 79 760891 A G
CDZ96932 X.sub.7938 M8 79 760904 T C
CDZ96932 X.sub.7939 M8 79 760988 G T
CDZ96932 X.sub.7940 M8 79 761056 T C
CDZ96932 X.sub.7941 M8 79 761210 T C
CDZ96932 X.sub.7942 M8 79 768537 A G
CDZ96933 X.sub.7943 M8 79 776112 A G
CDZ96934 X.sub.7944 M8 79 776301 C A
CDZ96934 X.sub.7945 M8 79 776304 G T
CDZ96934 X.sub.7946 M8 79 780012 T C
CDZ96934 X.sub.7947 M8 79 786064 A G
CDZ96934 X.sub.7948 M8 79 798799 C T
CDZ96939 X.sub.7949 M8 79 973493 C T
CDZ97000 X.sub.7950 M8 79 993074 C T
CDZ97006 X.sub.7951 M8 79 1073437 C A
CDZ97033 X.sub.7952 M8 79 1123288 C T
CDZ97049 X.sub.7953 M8 79 1140763 G A
CDZ97053 X.sub.7954 M8 79 1209208 G A
CDZ97077 X.sub.7955 M8 79 1211985 G A
CDZ97077 X.sub.7956 M8 79 1229129 G A
CDZ97086 X.sub.7957 M8 79 1231740 C T
CDZ97087 X.sub.7958 M8 79 1254757 G A
CDZ97095 X.sub.7959 M8 79 1318034 C T
CDZ97117 X.sub.7960 M8 79 1336766 C T
CDZ97121 X.sub.7961 M8 79 1344338 G A
CDZ97124 X.sub.7962 M8 79 1371491 C T
CDZ97129 X.sub.7963 M8 79 1430954 G A
CDZ97152 X.sub.7964 M8 79 1494219 T A
CDZ97172 X.sub.7965 M8 79 1540205 C T
CDZ97186 X.sub.7966 M8 79 1541574 G A
CDZ97186 X.sub.7967 M8 79 1624415 G A
CDZ97217 X.sub.7968 M8 79 1658469 C T
CDZ97227 X.sub.7969 M8 79 1674448 G A
CDZ97228 X.sub.7970 M8 79 1694516 C T
CDZ97233 X.sub.7971 M8 79 1696776 G A
CDZ97234 X.sub.7972 M8 79 1738540 A T
CDZ97247 X.sub.7973 M8 79 1772244 G A
CDZ97258 X.sub.7974 M8 79 1788096 G A
CDZ97262 X.sub.7975 M8 79 1791482 G A
CDZ97263 X.sub.7976 M8 79 1797660 C T
CDZ97265 X.sub.7977 M8 79 1797676 G A
CDZ97265 X.sub.7978 M8 79 1809211 C T
CDZ97268 X.sub.7979 M8 79 1842448 G A
CDZ97282 X.sub.7980 M8 79 1855037 A G
CDZ97285 X.sub.7981 M8 79 1859220 A G
CDZ97291 X.sub.7982 M8 79 1863178 A T
CDZ97292 X.sub.7983 M8 79 1930688 G A
CDZ97315 X.sub.7984 M8 79 2001789 C T
CDZ97339 X.sub.7985 M8 79 2002072 C T
CDZ97339 X.sub.7986 M8 79 2013361 C T
CDZ97344 X.sub.7987 M8 79 2113064 G A
CDZ97381 X.sub.7988 M8 79 2115870 G A
CDZ97380 X.sub.7989 M8 79 2121041 G A
CDZ97380 X.sub.7990 M8 79 2152573 C T
CDZ97392 X.sub.7991 M8 79 2172085 C T
CDZ97397 X.sub.7992 M8 79 2182096 G A
CDZ97403 X.sub.7993 M8 79 2188410 G A
CDZ97405 X.sub.7994 M8 79 2220254 C T
CDZ97414 X.sub.7995 M8 79 2268540 C T
CDZ97435 X.sub.7996 M8 79 2304361 G A
CDZ97450 X.sub.7997 M8 79 2317043 G A
CDZ97452 X.sub.7998 M8 79 2339881 C G
CDZ97460 X.sub.7999 M8 79 2340326 G A
CDZ97462 X.sub.8000 M8 85 462 G A
X.sub.8001 M8 85 463 A G
X.sub.8002 M8 85 467 A T
X.sub.8003 M8 85 512 A G
X.sub.8004 M8 85 516 G A
X.sub.8005 M8 85 521 C T
X.sub.8006 M8 85 522 A G
X.sub.8007 M8 88 119 C T
CDZ97464 X.sub.8008 M8 88 196 G A
CDZ97464 X.sub.8009 M8 88 898 C T
CDZ97464 X.sub.8010 M8 99 245 G A
X.sub.8011 M8 105 429 C T
CDZ97474 X.sub.8012 M8 109 396 T C
X.sub.8013 M8 113 411 G A
X.sub.8014 M8 118 396 C T
CDZ97478 X.sub.8015 M8 118 870 G A
CDZ97478 X.sub.8016 M8 118 1491 G A
CDZ97478 X.sub.8017 M8 121 318 A T
X.sub.8018 M8 124 72117 G A
CDZ97501 X.sub.8019 M8 124 72760 G A
CDZ97501 X.sub.8020 M8 124 94611 G A
CDZ97507 X.sub.8021 M8 124 156052 G A
CDZ97524 X.sub.8022 M8 124 166988 C T
CDZ97527 X.sub.8023 M8 124 207992 C T
CDZ97541 X.sub.8024 M8 124 222249 C T
CDZ97547 X.sub.8025 M8 125 35864 T C
CDZ97573 X.sub.8026 M8 126 104 C T
X.sub.8027 M8 129 299 G A
CDZ97577 X.sub.8028 M8 129 433 G A
CDZ97577 X.sub.8029 M8 129 856 G A
CDZ97577 X.sub.8030 M8 129 1013 C T
CDZ97577 X.sub.8031 M8 130 674 C T
CDZ97578 X.sub.8032 M8 141 5931 G A
CDZ97582 X.sub.8033 M8 141 15764 C T
CDZ97587 X.sub.8034 M8 141 17894 G A
CDZ97587 X.sub.8035 M8 141 25126 C T
CDZ97591 X.sub.8036 M8 149 1663 A G
CDZ97598 X.sub.8037 M8 149 2074 T G
CDZ97598 X.sub.8038 M8 152 141 G A
X.sub.8039 M8 159 106 A C
X.sub.8040 M8 162 70025 C T
CDZ97625 X.sub.8041 M8 162 70405 A G
CDZ97625 X.sub.8042 M8 162 93443 G A
CDZ97631 X.sub.8043 M8 162 199495 G A
CDZ97664 X.sub.8044 M8 162 207179 C T
CDZ97668 X.sub.8045 M8 162 207236 G A
CDZ97666 X.sub.8046 M8 162 223407 C T
CDZ97674 X.sub.8047 M8 162 233092 C T
CDZ97676 X.sub.8048 M8 162 268123 G A
CDZ97688 X.sub.8049 M8 162 291566 G A
CDZ97695 X.sub.8050 M8 162 304976 A G
CDZ97701 X.sub.8051 M8 162 308369 T C
CDZ97702 X.sub.8052 M8 162 321460 C G
CDZ97703 X.sub.8053 M8 162 321463 A C
CDZ97703 X.sub.8054 M8 162 322591 G A
CDZ97703 X.sub.8055 M8 162 324114 T C
CDZ97703 X.sub.8056 M8 162 324139 C T
CDZ97703 X.sub.8057 M8 16 324568 A G
CDZ97703 X.sub.8058 M8 162 324604 G A
CDZ97703 X.sub.8059 M8 162 351016 C T
CDZ97711 X.sub.8060 M8 162 360320 G A
CDZ97714 X.sub.8061 M8 162 424391 C T
CDZ97740 X.sub.8062 M8 162 444123 T C
CDZ97748 X.sub.8063 M8 162 457645 G A
CDZ97752 X.sub.8064 M8 162 467207 C T
CDZ97755 X.sub.8065 M8 162 476267 C T
CDZ97760 X.sub.8066 M8 162 491906 G A
CDZ97764 X.sub.8067 M8 162 492101 G A
CDZ97764 X.sub.8068 M8 162 501886 C T
CDZ97769 X.sub.8069 M8 162 541612 G A
CDZ97784 X.sub.8070 M8 162 632311 G A
CDZ97814 X.sub.8071 M8 162 633321 G A
CDZ97814 X.sub.8072 M8 162 633633 G A
CDZ97814 X.sub.8073 M8 162 638083 C T
CDZ97814 X.sub.8074 M8 162 640005 C T
CDZ97815 X.sub.8075 M8 162 674192 C T
CDZ97824 X.sub.8076 M8 162 680645 G A
CDZ97826 X.sub.8077 M8 162 738675 G A
CDZ97842 X.sub.8078 M8 162 738686 C T
CDZ97842 X.sub.8079 M8 162 808830 G A
CDZ97869 X.sub.8080 M8 162 861370 G T
CDZ97889 X.sub.8081 M8 162 871911 C T
CDZ97890 X.sub.8082 M8 162 914850 C T
CDZ97904 X.sub.8083 M8 162 966019 C T
CDZ97923 X.sub.8084 M8 162 972973 G A
CDZ97925 X.sub.8085 M8 162 997234 C T
CDZ97933 X.sub.8086 M8 175 385 A C
X.sub.8087 M8 185 758 C T
CDZ97958 X.sub.8088 M8 189 1306 C T
CDZ97961 X.sub.8089 M8 189 126573 G A
CDZ97996 X.sub.8090 M8 189 127356 G A
CDZ97996 X.sub.8091 M8 189 149091 G A
CDZ98004 X.sub.8092 M8 189 174918 G A
CDZ98015 X.sub.8093 M8 189 194647 A G
CDZ98020 X.sub.8094 M8 189 194665 A G
CDZ98020 X.sub.8095 M8 189 212649 C T
CDZ98028 X.sub.8096 M8 189 257670 C T
CDZ98041 X.sub.8097 M8 189 300343 C T
CDZ98056 X.sub.8098 M8 189 323680 C T
CDZ98063 X.sub.8099 M8 189 332957 G A
CDZ98065 X.sub.8100 M8 189 371247 G A
CDZ98078 X.sub.8101 M8 191 342 A G
CDZ98107 X.sub.8102 M8 191 347 C T
CDZ98107 X.sub.8103 M8 191 427 C T
CDZ98107 X.sub.8104 M8 191 451 C T
CDZ98107 X.sub.8105 M8 191 487 A G
CDZ98107 X.sub.8106 M8 197 624 C T
CDZ98111 X.sub.8107 M8 198 202 C A
X.sub.8108 M8 198 203 G A
X.sub.8109 M8 198 238 C T
X.sub.8110 M8 198 265 C T
X.sub.8111 M8 199 688 C T
X.sub.8112 M8 199 911 C T
X.sub.8113 M8 199 971 C T
X.sub.8114 M8 199 1218 C T
X.sub.8115 M8 202 171 C T
X.sub.8116 M8 205 360 C T
CDZ98112 X.sub.8117 M8 205 981 C T
CDZ98112 X.sub.8118 M8 208 117 G A
X.sub.8119 M8 208 476 G A
X.sub.8120 M8 208 616 G A
X.sub.8121 M8 208 935 G A
X.sub.8122 M8 209 312 C T
CDZ98113 X.sub.8123 M8 21 197 C G
CDZ98116 X.sub.8124 M8 223 93 G A
CDZ98118 X.sub.8125 M8 223 102 A G
CDZ98118 X.sub.8126 M8 223 133 A G
CDZ98118 X.sub.8127 M8 223 150 T C
CDZ98118 X.sub.8128 M8 223 155 A C
CDZ98118 X.sub.8129 M8 223 158 T C
CDZ98118 X.sub.8130 M8 223 160 C T
CDZ98118 X.sub.8131 M8 223 175 G A
CDZ98118 X.sub.8132 M8 223 177 A G
CDZ98118 X.sub.8133 M8 22 291 C A
CDZ98118 X.sub.8134 M8 225 317 C T
X.sub.8135 M8 227 202 G A
X.sub.8136 M8 232 340 G A
CDZ98119 X.sub.8137 M8 232 1379 C T
CDZ98119 X.sub.8138 M8 232 1521 C T
CDZ98119 X.sub.8139 M8 232 1662 G A
CDZ98119 X.sub.8140 M8 232 1761 C T
CDZ98119 X.sub.8141 M8 232 2027 C T
CDZ98119 X.sub.8142 M8 232 3060 C T
CDZ98120 X.sub.8143 M8 232 3284 C T
CDZ98119 X.sub.8144 M8 232 4437 G A
CDZ98121 X.sub.8145 M8 232 4561 C T
CDZ98120 X.sub.8146 M8 242 7334 C T
CDZ98125 X.sub.8147 M8 242 41710 G A
CDZ98131 X.sub.8148 M8 242 50262 G A
CDZ98135 X.sub.8149 M8 242 57480 C T
CDZ98137 X.sub.8150 M8 242 88037 G A
CDZ98147 X.sub.8151 M8 242 107587 G A
CDZ98153 X.sub.8152 M8 242 112244 G A
CDZ98154 X.sub.8153 M8 242 147104 G A
CDZ98164 X.sub.8154 M8 242 155049 C T
CDZ98168 X.sub.8155 M8 242 168689 G A
CDZ98172 X.sub.8156 M8 242 194983 C T
CDZ98179 X.sub.8157 M8 242 213986 G A
CDZ98185 X.sub.8158 M8 242 219778 C T
CDZ98187 X.sub.8159 M8 242 227271 C T
CDZ98191 X.sub.8160 M8 242 233088 G A
CDZ98193 X.sub.8161 M8 242 263218 G T
CDZ98201 X.sub.8162 M8 242 263678 G T
CDZ98202 X.sub.8163 M8 242 310353 G A
CDZ98216 X.sub.8164 M8 242 376713 G A
CDZ98238 X.sub.8165 M8 242 404132 G A
CDZ98248 X.sub.8166 M8 242 405825 G A
CDZ98250 X.sub.8167 M8 242 412676 G A
CDZ98249 X.sub.8168 M8 242 437941 G A
CDZ98258 X.sub.8169 M8 242 485936 G A
CDZ98270 X.sub.8170 M8 242 492389 G A
CDZ98274 X.sub.8171 M8 242 499956 A G
CDZ98276 X.sub.8172 M8 242 514780 C T
CDZ98282 X.sub.8173 M8 242 542663 G A
CDZ98290 X.sub.8174 M8 242 559999 G A
CDZ98297 X.sub.8175 M8 242 602456 G A
CDZ98308 X.sub.8176 M8 242 602531 G A
CDZ98308 X.sub.8177 M8 242 604704 C T
CDZ98309 X.sub.8178 M8 242 630157 C T
CDZ98319 X.sub.8179 M8 249 5307 C T
CED84929 X.sub.8180 M8 249 17416 A G
CED84933 X.sub.8181 M8 249 72016 C T
CED84950 X.sub.8182 M8 249 137338 G A
CED84976 X.sub.8183 M8 249 157550 C T
CED84983 X.sub.8184 M8 249 171600 G A
CED84986 X.sub.8185 M8 249 191304 C T
CED84988 X.sub.8186 M8 249 212696 G A
CED84994 X.sub.8187 M8 249 253494 C T
CED85008 X.sub.8188 M8 249 272075 C T
CED85013 X.sub.8189 M8 249 285231 C T
CED85015 X.sub.8190 M8 249 294161 G A
CED85018 X.sub.8191 M8 249 305975 G A
CED85023 X.sub.8192 M8 249 311154 G A
CED85025 X.sub.8193 M8 249 359266 C T
CED85041 X.sub.8194 M8 249 371535 G A
CED85048 X.sub.8195 M8 249 377814 G A
CED85051 X.sub.8196 M8 249 420458 C T
CED85069 X.sub.8197 M8 249 485782 C T
CED85089 X.sub.8198 M8 249 500195 C T
CED85093 X.sub.8199 M8 249 501310 C T
CED85093 X.sub.8200 M8 249 501510 T C
CED85093 X.sub.8201 M8 249 509901 C T
CED85096 X.sub.8202 M8 249 532943 A G
CED85099 X.sub.8203 M8 249 576070 G A
CED85118 X.sub.8204 M8 249 598579 C T
CED85125 X.sub.8205 M8 249 626627 G A
CED85132 X.sub.8206 M8 249 637944 G A
CED85135 X.sub.8207 M8 249 660408 G A
CED85144 X.sub.8208 M8 249 715551 G A
CED85163 X.sub.8209 M8 249 751427 G A
CED85174 X.sub.8210 M8 249 803215 C T
CED85186 X.sub.8211 M8 249 805141 T A
CED85187 X.sub.8212 M8 249 854220 G A
CED85201 X.sub.8213 M8 249 871689 G A
CED85204 X.sub.8214 M8 249 889853 G A
CED85211 X.sub.8215 M8 249 911274 C T
CED85218 X.sub.8216 M8 249 927876 C T
CED85222 X.sub.8217 M8 249 932606 C T
CED85223 X.sub.8218 M8 249 934305 G A
CED85225 X.sub.8219 M8 249 935435 C T
CED85225 X.sub.8220 M8 249 945434 C T
CED85227 X.sub.8221 M8 249 945727 C T
CED85227 X.sub.8222 M8 249 969333 G T
CED85238 X.sub.8223 M8 249 977170 C T
CED85242 X.sub.8224 M8 249 983120 T A
CED85242 X.sub.8225 M8 249 989520 C T
CED85243 X.sub.8226 M8 249 1014098 C T
CED85252 X.sub.8227 M8 249 1021827 C T
CED85254 X.sub.8228 M8 249 1050123 C T
CED85262 X.sub.8229 M8 249 1062282 G A
CED85266 X.sub.8230 M8 249 1067266 G A
CED85267 X.sub.8231 M8 249 1075522 G A
CED85270 X.sub.8232 M8 249 1076333 G A
CED85270 X.sub.8233 M8 249 1089152 G A
CED85274 X.sub.8234 M8 249 1108583 A G
CED85281 X.sub.8235 M8 249 1114790 G A
CED85283 X.sub.8236 M8 249 1143228 C T
CED85292 X.sub.8237 M8 249 1144309 G A
CED85291 X.sub.8238 M8 249 1176977 G A
CED85303 X.sub.8239 M8 249 1195367 G A
CED85307 X.sub.8240 M8 249 1230068 C T
CED85319 X.sub.8241 M8 249 1299472 C T
CED85343 X.sub.8242 M8 249 1359399 G A
CED85360 X.sub.8243 M8 249 1391343 G A
CED85372 X.sub.8244 M8 249 1393971 G A
CED85373 X.sub.8245 M8 249 1457529 G A
CED85398 X.sub.8246 M8 249 1473400 C T
CED85404 X.sub.8247 M8 249 1475200 G A
CED85404 X.sub.8248 M8 249 1486325 G A
CED85409 X.sub.8249 M8 249 1498029 T C
CED85415 X.sub.8250 M8 249 1502631 G T
CED85416 X.sub.8251 M8 249 1502641 T A
CED85416 X.sub.8252 M8 249 1502819 T G
CED85416 X.sub.8253 M8 249 1505138 G A
CED85416 X.sub.8254 M8 249 1505634 T G
CED85416 X.sub.8255 M8 249 1519431 A G
CED85419 X.sub.8256 M8 249 1555472 C T
CED85428 X.sub.8257 M8 249 1619036 G A
CED85450 X.sub.8258 M8 249 1621516 G A
CED85451 X.sub.8259 M8 249 1623151 G A
CED85451 X.sub.8260 M8 249 1653615 T G
CED85457 X.sub.8261 M8 249 1653962 C T
CED85458 X.sub.8262 M8 249 1655479 C T
CED85458 X.sub.8263 M8 249 1666185 C T
CED85460 X.sub.8264 M8 249 1679615 G A
CED85461 X.sub.8265 M8 249 1726777 C T
CED85474 X.sub.8266 M8 249 1737431 C T
CED85478 X.sub.8267 M8 249 1780551 A G
CED85493 X.sub.8268 M8 249 1780569 A G
CED85493 X.sub.8269 M8 249 1782582 G T
CED85493 X.sub.8270 M8 249 1786050 C T
CED85496 X.sub.8271 M8 249 1801965 G A
CED85501 X.sub.8272 M8 249 1803575 C T
CED85502 X.sub.8273 M8 249 1803790 G A
CED85502 X.sub.8274 M8 249 1804835 G A
CED85502 X.sub.8275 M8 249 1834426 G A
CED85511 X.sub.8276 M8 249 1880762 G A
CED85525 X.sub.8277 M8 249 1944026 G A
CED85545 X.sub.8278 M8 249 1988505 C T
CED85560 X.sub.8279 M8 249 2010712 G A
CED85564 X.sub.8280 M8 249 2015272 G A
CED85567 X.sub.8281 M8 249 2027477 G A
CED85573 X.sub.8282 M8 249 2063467 G A
CED85586 X.sub.8283 M8 249 2110956 C T
CED85603 X.sub.8284 M8 249 2163304 G A
CED85618 X.sub.8285 M8 249 2170103 C T
CED85620 X.sub.8286 M8 249 2198205 G A
CED85628 X.sub.8287 M8 249 2223626 G A
CED85633 X.sub.8288 M8 249 2255547 G C
CED85640 X.sub.8289 M8 252 512 C T
X.sub.8290 M8 252 524 C T
X.sub.8291 M8 258 576 A G
X.sub.8292 M8 258 1139 A T
X.sub.8293 M8 260 156 G A
X.sub.8294 M8 262 4049 G A
CDZ98330 X.sub.8295 M8 262 30347 G A
CDZ98338 X.sub.8296 M8 262 30359 G A
CDZ98338 X.sub.8297 M8 262 39621 C T
CDZ98342 X.sub.8298 M8 262 109833 C T
CDZ98369 X.sub.8299 M8 262 130174 C T
CDZ98372 X.sub.8300 M8 262 138889 C T
CDZ98375 X.sub.8301 M8 262 144566 G A
CDZ98375 X.sub.8302 M8 262 148151 C T
CDZ98375 X.sub.8303 M8 262 164438 G A
CDZ98383 X.sub.8304 M8 262 191816 C T
CDZ98393 X.sub.8305 M8 262 201531 G A
CDZ98396 X.sub.8306 M8 262 226006 C A
CDZ98404 X.sub.8307 M8 262 233570 G A
CDZ98407 X.sub.8308 M8 262 252305 G A
CDZ98412 X.sub.8309 M8 262 319302 G A
CDZ98436 X.sub.8310 M8 262 327677 C T
CDZ98440 X.sub.8311 M8 262 366171 G A
CDZ98452 X.sub.8312 M8 262 373766 C T
CDZ98456 X.sub.8313 M8 262 380519 C T
CDZ98457 X.sub.8314 M8 262 390030 C T
CDZ98460 X.sub.8315 M8 262 397539 G A
CDZ98463 X.sub.8316 M8 262 410688 C T
CDZ98466 X.sub.8317 M8 262 418834 C T
CDZ98468 X.sub.8318 M8 262 420102 G A
CDZ98468 X.sub.8319 M8 262 446956 C T
CDZ98477 X.sub.8320 M8 262 471054 C T
CDZ98487 X.sub.8321 M8 262 498239 C T
CDZ98496 X.sub.8322 M8 262 539428 G A
CDZ98514 X.sub.8323 M8 262 539452 A G
CDZ98514 X.sub.8324 M8 262 539470 A G
CDZ98514 X.sub.8325 M8 262 539588 A G
CDZ98514 X.sub.8326 M8 262 552414 C T
CDZ98518 X.sub.8327 M8 262 557280 G A
CDZ98518 X.sub.8328 M8 262 560713 G A
CDZ98519 X.sub.8329 M8 262 562795 C T
CDZ98521 X.sub.8330 M8 262 567591 G A
CDZ98524 X.sub.8331 M8 262 567801 G A
CDZ98524 X.sub.8332 M8 262 618198 G A
CDZ98538 X.sub.8333 M8 262 627573 T C
CDZ98542 X.sub.8334 M8 262 627705 C T
CDZ98542 X.sub.8335 M8 262 628911 G C
CDZ98543 X.sub.8336 M8 262 632409 A T
CDZ98543 X.sub.8337 M8 262 632450 T G
CDZ98543 X.sub.8338 M8 262 632476 T C
CDZ98543 X.sub.8339 M8 262 638804 G C
CDZ98544 X.sub.8340 M8 262 638833 G T
CDZ98544 X.sub.8341 M8 262 639962 A G
CDZ98544 X.sub.8342 M8 262 640066 A G
CDZ98544 X.sub.8343 M8 262 644395 A G
CDZ98544 X.sub.8344 M8 262 653920 A G
CDZ98545 X.sub.8345 M8 262 655754 A T
CDZ98545 X.sub.8346 M8 262 655757 T C
CDZ98545 X.sub.8347 M8 262 656323 C G
CDZ98545 X.sub.8348 M8 262 666563 G A
CDZ98545 X.sub.8349 M8 262 668764 C T
CDZ98545 X.sub.8350 M8 262 669984 C T
CDZ98547 X.sub.8351 M8 262 691577 C T
CDZ98551 X.sub.8352 M8 262 771330 G A
CDZ98578 X.sub.8353 M8 262 801565 G A
CDZ98589 X.sub.8354 M8 262 822734 G A
CDZ98597 X.sub.8355 M8 262 825723 A G
CDZ98598 X.sub.8356 M8 262 835874 C T
CDZ98601 X.sub.8357 M8 262 865999 G A
CDZ98613 X.sub.8358 M8 262 886842 C T
CDZ98621 X.sub.8359 M8 262 971713 G A
CDZ98649 X.sub.8360 M8 262 1011054 G A
CDZ98659 X.sub.8361 M8 262 1051389 C T
CDZ98670 X.sub.8362 M8 262 1076581 G A
CDZ98679 X.sub.8363 M8 262 1107286 C T
CDZ98689 X.sub.8364 M8 262 1140198 C T
CDZ98701 X.sub.8365 M8 262 1152058 C A
CDZ98703 X.sub.8366 M8 262 1209662 G A
CDZ98723 X.sub.8367 M8 262 1226072 C T
CDZ98730 X.sub.8368 M8 262 1237021 C T
CDZ98735 X.sub.8369 M8 262 1257961 C T
CDZ98739 X.sub.8370 M8 262 1277604 G A
CDZ98747 X.sub.8371 M8 262 1284428 G A
CDZ98748 X.sub.8372 M8 262 1305361 G A
CDZ98753 X.sub.8373 M8 262 1329643 C T
CDZ98760 X.sub.8374 M8 262 1351116 A G
CDZ98766 X.sub.8375 M8 262 1415479 C T
CDZ98789 X.sub.8376 M8 262 1424293 G A
CDZ98791 X.sub.8377 M8 262 1455677 G A
CDZ98804 X.sub.8378 M8 262 1458863 C T
CDZ98807 X.sub.8379 M8 262 1550311 C T
CDZ98836 X.sub.8380 M8 262 1550456 C T
CDZ98837 X.sub.8381 M8 262 1615762 G A
CDZ98855 X.sub.8382 M8 262 1677620 G A
CDZ98873 X.sub.8383 M8 262 1684375 G A
CDZ98876 X.sub.8384 M8 262 1694625 C T
CDZ98878 X.sub.8385 M8 262 1712334 G A
CDZ98886 X.sub.8386 M8 262 1716385 G A
CDZ98887 X.sub.8387 M8 262 1717611 C T
CDZ98888 X.sub.8388 M8 266 85 C T
X.sub.8389 M8 266 252 C T
X.sub.8390 M8 267 93 G A
X.sub.8391 M8 267 94 A G
X.sub.8392 M8 267 133 T C
X.sub.8393 M8 267 134 C T
X.sub.8394 M8 267 201 T C
X.sub.8395 M8 267 208 T C
indicates data missing or illegible when filed
TABLE-US-00013 TABLE 13 V RS RP RB SB T GC CDS AA Change Y.sub.1 22 1643 C T 2 cytochrome c oxidase subunit 1 CED80056 p.Leu366Phe Y.sub.2 22 2524 G A 4 cytochrome c oxidase subunit 1 CED80056 Y.sub.3 28 236 G A 3 atp synthase subunit 6 CDZ96150 Y.sub.4 28 377 G A 3 atp synthase subunit 6 CDZ96150 Y.sub.5 28 1506 C T 2 atp synthase subunit 6 CDZ96150 p.Ala227Val Y.sub.6 28 1677 C T 4 atp synthase subunit 6 CDZ96150 Y.sub.7 43 464 G A 2 nadh dehydrogenase subunit 4 CDZ96151 p.Thr147Ile Y.sub.8 43 753 C T 2 nadh dehydrogenase subunit 4 CDZ96151 p.Val51Ile Y.sub.9 43 1527 C T 3 nadh dehydrogenase subunit 4 CDZ96151 Y.sub.10 43 1748 G A 3 nadh dehydrogenase subunit 4 CDZ96151 Y.sub.11 43 1928 C T 3 nadh dehydrogenase subunit 4 CDZ96151 Y.sub.12 62 875 G A 2 cytochrome c oxidase subunit 2 CDZ96152 p.Thr110Ile Y.sub.13 102 339 C T 4 NADH dehydrogenase subunits 2, 5, and related proteins CDZ96153 Y.sub.14 102 951 G A 4 NADH dehydrogenase subunits 2, 5, and related proteins CDZ96153 Y.sub.15 102 1042 G A 4 NADH dehydrogenase subunits 2, 5, and related proteins CDZ96153 Y.sub.16 102 2334 G A 2 NADH dehydrogenase subunits 2, 5, and related proteins CDZ96153 p.Ser181Phe Y.sub.17 102 2590 C T 2 NADH dehydrogenase subunits 2, 5, and related proteins CDZ96153 p.Ala96Thr Y.sub.18 102 3427 C T 3 NADH dehydrogenase subunits 2, 5, and related proteins CDZ96153 Y.sub.19 176 358 G A 3 cytochrome b CED80058 Y.sub.20 176 1872 G A 4 cytochrome b CED80058 Y.sub.21 176 1980 G A 4 cytochrome b CED80058 Y.sub.22 179 1525 G A 7 NADH CDZ96154 Y.sub.23 179 1780 C T 7 NADH CDZ96154 Y.sub.24 188 815 C T 2 nadh dehydrogenase subunit 6 CED80060 p.Ala79Val Y.sub.25 188 1174 C T 4 nadh dehydrogenase subunit 6 CED80060 Y.sub.26 188 2163 G A 4 nadh dehydrogenase subunit 6 CED80060 Y.sub.27 188 2170 G A 4 nadh dehydrogenase subunit 6 CED80060 Y.sub.28 247 102 G A 4 cytochrome c oxidase subunit 3 CED80061 Y.sub.29 247 989 C T 2 cytochrome c oxidase subunit 3 CED80061 p.Gly104Glu Y.sub.30 247 1053 G A 2 cytochrome c oxidase subunit 3 CED80061 p.Leu83Phe Y.sub.31 7 160 T C 6 Y.sub.32 8 1110 C T 6 Y.sub.33 11 154 A C 6 Y.sub.34 11 158 C T 6 Y.sub.35 15 28 C G 6 Y.sub.36 24 5850 C T 2 hypothetical protein CDZ96160 p.Leu85Phe Y.sub.37 24 180340 G A 3 V-SNARE CDZ96216 Y.sub.38 24 307114 G A 2 DNA polymerase zeta, catalytic subunit CDZ96255 p.Gly717Glu Y.sub.39 24 340663 T C 3 mRNA splicing factor CDZ96265 Y.sub.40 24 420108 G A 3 Ubiquitin-conjugating enzyme E2-binding protein CDZ96291 Y.sub.41 27 445 C T 6 Y.sub.42 27 1012 A C 6 Y.sub.43 27 1013 T A 6 Y.sub.44 32 158 C T 3 hypothetical protein CDZ96332 Y.sub.45 32 215 C T 3 hypothetical protein CDZ96332 Y.sub.46 32 2438 C T 3 hypothetical protein CDZ96332 Y.sub.47 32 2821 C T 7 hypothetical protein CDZ96332 Y.sub.48 32 3067 C T 2 hypothetical protein CDZ96332 p.Ser105Phe Y.sub.49 32 3506 C T 4 hypothetical protein CDZ96332 Y.sub.50 32 3562 G A 4 hypothetical protein CDZ96332 Y.sub.51 33 45488 C T 3 transcription coactivator CED82012 Y.sub.52 33 109397 G A 2 phosphoenolpyruvate carboxykinase CED82038 p.Thr326Ile Y.sub.53 33 260027 G A 3 hypothetical protein CED82084 Y.sub.54 33 274627 G A 8 Mercaptopyruvate sulfurtransferase/thiosulfate CED82091 p.Ala256Thr sulfurtransferase Y.sub.55 33 283808 C T 2 HLH transcription factor EBF/Olf-1 and related CED82093 p.Gly36Asp DNA binding proteins Y.sub.56 33 341890 G A 2 Peptidase S9, prolyl oligopeptidase, catalytic domain CED82113 p.Pro656Ser Y.sub.57 33 448815 G A 2 cap1-related protein CED82144 p.Val460Ile Y.sub.58 33 453975 C T 2 C4-type Zn-finger protein CED82147 p.Asp703Asn Y.sub.59 33 455451 C T 3 hypothetical protein CED82146 Y.sub.60 33 509127 C T 3 Endonuclease MUS81 CED82166 Y.sub.61 33 693516 C T 2 p-loop containing nucleoside triphosphate CED82225 p.Leu417Phe hydrolase protein Y.sub.62 33 1049699 G A 3 Inorganic phosphate transporter CED82334 Y.sub.63 33 1138444 C T 3 Nuclear AAA ATPase (VCP subfamily) CED82363 Y.sub.64 33 1165914 G A 2 leucine-trna ligase CED82372 p.Ser992Phe Y.sub.65 33 1191727 C T 2 xanthine uracil permease CED82379 p.Ser617Asn Y.sub.66 33 1324395 G A 3 Basic-leucine zipper domain CED82417 Y.sub.67 33 1339376 C T 2 DNA-binding centromere protein B (CENP-B) CED82424 p.Thr69Met Y.sub.68 33 1499347 G A 3 Dimeric dihydrodiol dehydrogenase CED82472 Y.sub.69 33 1502644 G A 2 pre-mrna splicing factor prp1 CED82474 p.Pro248Ser Y.sub.70 33 1515369 G A 3 hypothetical protein CED82478 Y.sub.71 33 1544951 C G 6 hypothetical protein CED82485 Y.sub.72 33 1587443 C T 3 atp-dependent clp protease proteolytic subunit CED82497 Y.sub.73 33 1596242 C T 3 myosin 5 CED82498 Y.sub.74 33 1638726 G A 3 hypothetical protein CED82513 Y.sub.75 33 1642659 G A 2 Uncharacterized MYND Zn-finger protein CED82515 p.Ala199Thr Y.sub.76 33 1700000 G A 2 hypothetical protein CED82534 p.Pro888Ser Y.sub.77 33 1938614 G A 2 Splicing factor 3b, subunit 2 CED82612 p.His486Tyr Y.sub.78 33 2010230 C T 2 OCH1 CED82636 p.Thr257Ile Y.sub.79 33 2014235 C T 2 Putative phosphoinositide phosphatase CED82637 p.Val106Ile Y.sub.80 36 320 G A 6 Y.sub.81 36 1056 G A 6 Y.sub.82 36 1295 C T 6 Y.sub.83 36 1461 A T 6 Y.sub.84 42 804 C T 4 atp synthase subunit mitochondrial CDZ96333 Y.sub.85 42 1559 G A 4 atp synthase subunit mitochondrial CDZ96333 Y.sub.86 50 145 G A 6 Y.sub.87 52 63859 C T 2 kinase-like protein CED82686 p.Pro363Ser Y.sub.88 52 144382 C T 3 hypothetical protein CED82709 Y.sub.89 52 151974 C T 2 Predicted small molecule transporter CED82712 p.Gly179Glu Y.sub.90 52 203253 A G 3 B-block binding subunit of TFIIIC CED82730 Y.sub.91 52 207354 C T 8 B-block binding subunit of TFIIIC CED82730 Y.sub.92 52 390095 G A 3 pre-mrna-splicing factor clf1 CED82784 Y.sub.93 52 395374 G A 2 transcriptional regulator CED82786 p.Pro371Ser Y.sub.94 52 398723 C T 3 transcriptional regulator CED82786 Y.sub.95 52 398728 C T 3 transcriptional regulator CED82786 Y.sub.96 52 552099 G A 2 Zuotin and related molecular chaperones (DnaJ CED82837 p.Val134Ile superfamily), contains DNA-binding domains Y.sub.97 52 817452 T A 2 atypical pikk frap protein kinase CED82928 p.His270Leu Y.sub.98 52 938650 G A 3 hypothetical protein CED82973 Y.sub.99 52 967316 A T 2 1,4-alpha-glucan branching enzyme/starch CED82984 p.Glu582Val branching enzyme II Y.sub.100 52 967701 T A 3 cyclin-dependent kinase regulatory subunit CED82983 Y.sub.101 52 1003899 G A 2 heat shock protein 60 ame CED83001 p.Gly126Asp Y.sub.102 52 1151398 G A 3 FOG CED83046 Y.sub.103 52 1158103 C T 3 Density-regulated protein related to translation CED83051 initiation factor 1 (elF-1/SUI1) Y.sub.104 52 1219894 C T 3 probable cdc12-septin CED83071 Y.sub.105 52 1363357 G A 3 mrg-domain-containing protein CED83122 Y.sub.106 52 1399439 G A 2 mitochondrial cytochrome b2- CED83134 p.Arg244Gln Y.sub.107 52 1526796 G A 2 eukaryotic translation initiation factor 2 subunit alpha CED83181 p.Gly134Glu Y.sub.108 52 1583655 C T 2 Predicted Zn-finger protein CED83206 p.Pro285Leu Y.sub.109 52 1708900 A G 3 dna mismatch repair protein CED83249 Y.sub.110 52 1716210 C T 3 atpase CED83250 Y.sub.111 52 1793370 G A 3 RNA polymerase II, subunit POLR2C/RPB3 CED83275 Y.sub.112 52 1807309 G A 3 Protein of unknown function DUF1264 CED83283 Y.sub.113 52 1871310 C T 2 Uncharacterized conserved protein CED83304 p.Ala574Val Y.sub.114 52 1893352 G A 2 atp-dependent metallopeptidase hfl CED83313 p.Pro375Leu Y.sub.115 52 1915927 G A 3 hypothetical protein CED83315 Y.sub.116 52 1987096 G A 4 Sexual differentiation process protein ISP4 CED83341 Y.sub.117 52 2050245 G A 3 Extracellular protein SEL-1 and related proteins CED83359 Y.sub.118 52 2120665 C T 4 hypothetical protein CED83376 Y.sub.119 52 2162878 G A 2 Nucleic acid-binding, OB-fold CED83392 p.Asp942Asn Y.sub.120 52 2258192 C T 2 hypothetical protein CED83422 p.Pro126Ser Y.sub.121 52 2265219 C T 2 hypothetical protein CED83425 p.Glu74Lys Y.sub.122 52 2266378 C T 3 dead-domain-containing protein CED83423 Y.sub.123 52 2327266 C T 3 60s ribosomal protein I21 CED83445 Y.sub.124 52 2373120 C T 2 Protein phosphatase, regulatory subunit CED83456 p.Gly789Glu PPP1R3C/D Y.sub.125 52 2400778 C T 4 atp-dependent rna helicase dhx8 CED83463 Y.sub.126 52 2543220 C T 3 Protein of unknown function DUF3468 CED83509 Y.sub.127 53 26291 G A 2 Uncharacterised protein family UPF0390 CDZ96348 p.Ser75Asn Y.sub.128 54 106086 G A 3 FOG CDZ96416 Y.sub.129 54 194230 G A 2 RmlC-like jelly roll fold CDZ96446 p.Pro179Ser Y.sub.130 54 206494 G A 2 white collar 1 protein CDZ96450 p.Asp88Asn Y.sub.131 54 370320 G A 2 UV radiation resistance associated protein CDZ96499 p.Thr57Ile Y.sub.132 54 391223 A G 2 SAP family cell cycle dependent phosphatase- CDZ96509 p.Asp477Gly associated protein Y.sub.133 54 427542 C T 2 Exosomal 3-5 exoribonuclease complex, subunit CDZ96520 p.Ser51Asn Rrp44/Dis3 Y.sub.134 54 431851 C T 3 Exosomal 3-5 exoribonuclease complex, subunit CDZ96520 Rrp44/Dis3 Y.sub.135 54 478527 C T 2 abc transporter CDZ96537 p.Val1423Ile Y.sub.136 54 555986 G A 2 hypothetical protein CDZ96563 p.Pro8Ser Y.sub.137 54 733193 T C start_lost hypothetical protein CDZ96619 p.Met1? Y.sub.138 67 111 G A 6 Y.sub.139 69 29006 G A 3 hypothetical protein CED83534 Y.sub.140 69 201005 G A 3 hypothetical protein CED83595 Y.sub.141 69 305997 C T 2 Peptidase M28 CED83631 p.Leu341Phe Y.sub.142 69 384418 G A 2 Delta 9 fatty acid desaturase CED83656 p.Ala149Thr Y.sub.143 69 415659 C T 2 microtubule binding protein CED83665 p.Asp305Asn Y.sub.144 69 467686 C T 2 dna replication factor large subunit CED83681 p.Asp244Asn Y.sub.145 69 585845 G A 2 beta and beta-prime subunits of dna dependent CED83722 p.Gly1099Ser rna-polymerase Y.sub.146 69 631511 G A 2 aspartate-semialdehyde dehydrogenase CED83742 p.Ala15Thr Y.sub.147 69 637299 T C 2 hypothetical protein CED83744 p.Thr41Ala Y.sub.148 69 675579 G A 3 hypothetical protein CED83760 Y.sub.149 69 676581 G A 2 hypothetical protein CED83760 p.Ala2Thr Y.sub.150 69 676853 G A 3 Metalloexopeptidases CED83759 Y.sub.151 69 678406 C T 3 Metalloexopeptidases CED83759 Y.sub.152 69 865820 C T 2 acyl-oxidase CED83814 p.Leu1253Phe Y.sub.153 69 869706 G A 8 Predicted E3 ubiquitin ligase CED83815 Y.sub.154 69 894462 C T 3 TPR repeat-containing protein CED83821 Y.sub.155 69 971219 C T 3 probable peroxisomal half abc transporter CED83847 Y.sub.156 69 988364 G A 2 hypothetical protein CED83857 p.Gly911Glu Y.sub.157 69 1102164 C T 2 nucleosome assembly protein CED83897 p.Glu89Lys Y.sub.158 69 1218409 G A 3 FOG CED83936 Y.sub.159 69 1260087 G A 3 mRNA cleavage and polyadenylation factor II CED83949 complex, subunit CFT2 (CPSF subunit) Y.sub.160 69 1342909 G A 3 Inositol polyphosphate multikinase, component CED83975 of the ARGR transcription regulatory complex Y.sub.161 69 1411421 C T 3 hypothetical protein CED83999 Y.sub.162 69 1652288 C T 3 atp-dependent rna helicase dbp5 CED84077 Y.sub.163 69 1714728 G A 3 hypothetical protein CED84097 Y.sub.164 69 1790823 C T 2 Protein of unknown function DUF1183, TMEM66 CED84125 p.Ala253Val Y.sub.165 69 1792597 C T 2 SMAD/FHA domain CED84126 p.Ala258Val Y.sub.166 69 1800584 G A 3 Uncharacterized conserved protein CED84129 Y.sub.167 69 1854739 G A 3 RNA polymerase II transcription CED84145 initiation/nucleotide excision repair factor TFIIH, subunit TFB2 Y.sub.168 69 1924621 C T 3 hypothetical protein CED84172 Y.sub.169 69 1968848 A G 3 Immunoglobulin-like fold CED84189 Y.sub.170 69 2001469 C T 3 pre-mrna splicing factor CED84197 Y.sub.171 69 2255001 G A 2 hypothetical protein CED84282 p.Ala239Val Y.sub.172 69 2438727 C T 3 g-protein alpha-subunit CED84343 Y.sub.173 69 2483433 G A 3 F-box protein containing LRR CED84352 Y.sub.174 72 584 G A 6 Y.sub.175 72 856 C T 6 Y.sub.176 72 1163 C T 6 Y.sub.177 77 84022 G A 8 DRIM (Down-regulated in metastasis)-like proteins CDZ96659 Y.sub.178 78 6333 G A 8 acid phosphatase CED84360 Y.sub.179 78 238854 C T 3 Extracellular matrix glycoprotein Laminin CED84430 subunits alpha and gamma Y.sub.180 78 299644 G A 3 hypothetical protein CED84443 Y.sub.181 78 444292 C T 2 gtp-binding protein ypt1 CED84490 p.Ala156Val Y.sub.182 78 666005 C T 3 Protein involved in DNA repair CED84562 Y.sub.183 78 763771 G A 3 mrna (guanine-n7-)-methyltransferase CED84600 Y.sub.184 78 774252 G A 2 ataxia telangiectasia mutated CED84602 p.Val2842Ile Y.sub.185 78 952815 G A 2 Ornithine decarboxylase antizyme CED84662 p.Gly246Glu Y.sub.186 78 952860 G A 2 Ornithine decarboxylase antizyme CED84662 p.Gly261Glu Y.sub.187 78 1023381 G A 2 Aldo/keto reductase family proteins CED84688 p.Val43Ile Y.sub.188 78 1302286 C T 3 Spermidine/spermine synthases family CED84782 Y.sub.189 78 1317124 G A 3 hypothetical protein CED84787 Y.sub.190 78 1344640 C T 3 Predicted membrane protein CED84795 Y.sub.191 78 1426722 C T 2 high-affinity cell membrane calcium channel CED84829 p.Val866Ile Y.sub.192 78 1568326 C T 2 WD40/YVTN repeat-like-containing domain CED84868 p.Val1033Ile Y.sub.193 78 1642170 G A 3 hypothetical protein CED84889 Y.sub.194 78 1660408 G A 2 golgi apparatus membrane protein tvp23 CED84897 p.Thr539Ile Y.sub.195 78 1694684 C T 2 Conserved hypothetical protein CHP02453 CED84912 p.Asp239Asn Y.sub.196 79 57804 G A 2 AAA-type ATPase CDZ96687 p.Glu1838Lys Y.sub.197 79 132683 C T 2 Immunoglobulin-like fold CDZ96713 p.Ser156Asn Y.sub.198 79 307021 C T 3 HSP20-like chaperone CDZ96777 Y.sub.199 79 346823 G A 2 Pantothenate kinase PanK and related proteins CDZ96789 p.Gly590Arg Y.sub.200 79 492523 C T 3 hypothetical protein CDZ96842 Y.sub.201 79 575411 C T 3 Mediator complex, subunit Med4 CDZ96868 Y.sub.202 79 617057 C T 2 M13 family peptidase CDZ96882 p.Gly670Asp Y.sub.203 79 679140 C T 2 ca-transporting atpase CDZ96904 p.Met334Ile Y.sub.204 79 696174 G A 4 CDZ96911 Y.sub.205 79 747717 A G 3 Predicted histone tail methylase containing CDZ96929 SET domain Y.sub.206 79 759589 G A 4 FOG CDZ96932 Y.sub.207 79 776112 A G 4 ribonuclease iii CDZ96934 Y.sub.208 79 1123288 C T 2 Zinc finger, RING-type CDZ97049 p.Thr364Ile Y.sub.209 79 1140763 G A 3 40s ribosomal protein s15 CDZ97053 Y.sub.210 79 1229129 G A 2 nuclear export receptor crm1 CDZ97086 p.Leu253Phe Y.sub.211 79 1231740 C T 2 voltage-gated chloride channel CDZ97087 p.Arg715His Y.sub.212 79 1336766 C T 4 phosphatidylinositol 4-kinase CDZ97121 Y.sub.213 79 1430954 G A 2 hypothetical protein CDZ97152 p.Pro1037Ser Y.sub.214 79 1540205 C T 2 Geranylgeranyl pyrophosphate synthase CDZ97186 p.Met237Ile Y.sub.215 79 1674448 G A 4 Membrane coat complex Retromer, CDZ97228 subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Y.sub.216 79 1797660 C T 3 Iron permease FTR1 CDZ97265 Y.sub.217 79 1797676 G A 3 Iron permease FTR1 CDZ97265 Y.sub.218 79 1842448 G A 2 t-complex protein alpha subunit (tcp-1-alpha) CDZ97282 p.Ser212Asn Y.sub.219 79 1855037 A G 3 hypothetical protein CDZ97285 Y.sub.220 79 2013361 C T 8 Predicted membrane protein CDZ97344 Y.sub.221 79 2027861 C T 8 Predicted short chain-type dehydrogenase CDZ97350 Y.sub.222 79 2121041 G A 3 Polyadenylation factor I complex, subunit, CDZ97380 Yth1 (CPSF subunit) Y.sub.223 79 2152573 C T 2 Predicted lipase CDZ97392 p.Gly230Asp Y.sub.224 79 2188410 G A 2 RNA polymerase III, subunit C34 CDZ97405 p.Glu121Lys Y.sub.225 85 512 A G 6 Y.sub.226 85 516 G A 6 Y.sub.227 88 119 C T 3 hypothetical protein CDZ97464 Y.sub.228 88 196 G A 3 hypothetical protein CDZ97464 Y.sub.229 88 898 C T 4 hypothetical protein CDZ97464 Y.sub.230 99 245 G A 6 Y.sub.231 109 396 T C 6 Y.sub.232 118 396 C T 2 hypothetical protein CDZ97478 p.Pro41Ser Y.sub.233 118 870 G A 4 hypothetical protein CDZ97478 Y.sub.234 118 1491 G A 4 hypothetical protein CDZ97478 Y.sub.235 124 72117 G A 2 p-loop containing nucleoside triphosphate CDZ97501 p.Gly510Asp hydrolase protein Y.sub.236 124 156052 G A 2 cytoplasm protein CDZ97524 p.Ala504Thr Y.sub.237 125 35864 T C 3 Plant ascorbate peroxidase CDZ97573 Y.sub.238 129 299 G A 3 hypothetical protein CDZ97577 Y.sub.239 129 433 G A 3 hypothetical protein CDZ97577 Y.sub.240 129 856 G A 2 hypothetical protein CDZ97577 p.Gly103Glu Y.sub.241 130 674 C T 4 hypothetical protein CDZ97578 Y.sub.242 141 15764 C T 2 lysine-trna ligase CDZ97587 p.Gly589Asp Y.sub.243 162 223407 C T 2 Protein of unknown function DUF2419 CDZ97674 p.Gly204Glu Y.sub.244 162 321070 C T 4 retrotransposon ty1-copia subclass CDZ97703 Y.sub.245 162 321073 A G 4 retrotransposon ty1-copia subclass CDZ97703 Y.sub.246 162 360320 G A 2 mRNA splicing factor CDZ97714 p.Ala393Val Y.sub.247 162 424391 C T 3 gtp-binding protein CDZ97740 Y.sub.248 162 444123 T C 2 ring finger protein CDZ97748 p.Asp157Gly Y.sub.249 162 467207 C T 3 cytochrome b5 CDZ97755 Y.sub.250 162 491906 G A 3 hypothetical protein CDZ97764 Y.sub.251 162 501886 C T 8 Tetraspanin/Peripherin CDZ97769 Y.sub.252 162 632311 G A 2 snf2 family amino-terminal protein CDZ97814 p.Gly88Asp Y.sub.253 162 633321 G A 2 snf2 family amino-terminal protein CDZ97814 p.Gly304Ser Y.sub.254 162 640005 C T 2 arginyl-trna synthetase CDZ97815 p.Arg318Lys Y.sub.255 162 808830 G A 3 dihydropteroate synthase CDZ97869 Y.sub.256 162 871911 C T 8 Predicted Zn-finger protein CDZ97890 Y.sub.257 189 126573 G A 3 START-like domain CDZ97996 Y.sub.258 189 323680 C T 2 hypothetical protein CDZ98063 p.Ala390Thr Y.sub.259 189 371247 G A 5 WD40 repeat-containing protein CDZ98078 p.Arg144* Y.sub.260 197 624 C T 3 hypothetical protein CDZ98111 Y.sub.261 198 238 C T 6 Y.sub.262 198 265 C T 6 Y.sub.263 199 688 C T 6 Y.sub.264 199 911 C T 6 Y.sub.265 199 971 C T 6 Y.sub.266 199 1218 C T 6 Y.sub.267 202 171 C T 6 Y.sub.268 205 360 C T 3 hypothetical protein CDZ98112 Y.sub.269 205 981 C T 4 hypothetical protein CDZ98112 Y.sub.270 208 117 G A 6 Y.sub.271 208 476 G A 6 Y.sub.272 208 616 G A 6 Y.sub.273 208 935 G A 6 Y.sub.274 209 312 C T 8 hypothetical protein CDZ98113 Y.sub.275 225 317 C T 6 Y.sub.276 227 202 G A 6 Y.sub.277 232 340 G A 3 hypothetical protein CDZ98119 Y.sub.278 232 1521 C T 2 hypothetical protein CDZ98119 p.Pro84Leu Y.sub.279 232 1662 G A 2 hypothetical protein CDZ98119 p.Ser131Asn Y.sub.280 232 1761 C T 2 hypothetical protein CDZ98119 p.Ser140Phe Y.sub.281 232 2027 C T 4 hypothetical protein CDZ98119 Y.sub.282 232 3060 C T 2 hypothetical protein CDZ98120 p.Gly115Glu Y.sub.283 232 3284 C T 4 hypothetical protein CDZ98119 Y.sub.284 232 4437 G A 2 hypothetical protein CDZ98121 p.Ser21Phe Y.sub.285 232 4561 C T 3 hypothetical protein CDZ98120 Y.sub.286 242 7334 C T 2 alanine-trna ligase CDZ98125 p.Asp781Asn Y.sub.287 242 41710 G A 3 Protein kinase essential for the initiation of CDZ98131 DNA replication Y.sub.288 242 50262 G A 8 palp-domain-containing protein CDZ98135 Y.sub.289 242 88037 G A 2 hypothetical protein CDZ98147 p.Leu39Phe Y.sub.290 242 107587 G A 4 arginase deacetylase CDZ98153 Y.sub.291 242 213986 G A 8 atp-nad kinase CDZ98185 p.Asp654Asn Y.sub.292 242 227271 C T 3 hypothetical protein CDZ98191 Y.sub.293 242 233088 G A 2 fumarate reductase CDZ98193 p.Gly11Glu Y.sub.294 242 310353 G A 2 hypothetical protein CDZ98216 p.Ser76Phe Y.sub.295 242 404132 G A 3 hypothetical protein CDZ98248 Y.sub.296 242 412676 G A 3 peptidase c1b bleomycin hydrolase CDZ98249 Y.sub.297 242 485936 G A 4 Cytochrome c oxidase, subunit IV/COX5b CDZ98270 Y.sub.298 242 492389 G A 2 1-aminocyclopropane-1-carboxylate CDZ98274 p.Glu201Lys synthase, and related proteins Y.sub.299 242 514780 C T 2 endosomal p24a protein CDZ98282 p.Val585Met Y.sub.300 242 542663 G A 3 Sirtuin 4 and related class Il sirtuins (SIR2 family) CDZ98290 Y.sub.301 242 559999 G A 2 Protein-tyrosine/Dual specificity phosphatase CDZ98297 p.Glu29Lys Y.sub.302 242 602456 G A 2 calcineurin responsive transcription factor prz1 CDZ98308 p.Asp190Asn Y.sub.303 242 602531 G A 2 calcineurin responsive transcription factor prz1 CDZ98308 p.Ala215Thr Y.sub.304 242 604704 C T 2 hypothetical protein CDZ98309 p.Pro155Leu Y.sub.305 249 72016 C T 3 hypothetical protein CED84950 Y.sub.306 249 157550 C T 8 acyl-n-acyltransferase CED84983 Y.sub.307 249 191304 C T 2 Maintenance of telomere capping protein 1, Mtc1 CED84988 p.Gly64Ser Y.sub.308 249 272075 C T 8 beta-1,6-N-acetylglucosaminyltransferase, CED85013 contains WSC domain Y.sub.309 249 305975 G A 2 Zn(2)-C6 fungal-type DNA-binding domain CED85023 p.Val135Ile Y.sub.310 249 485782 C T 3 Nuclear pore complex, Nup155 component CED85089 (D Nup154, sc Nup157/Nup170) Y.sub.311 249 501310 C T 3 hypothetical protein CED85093 Y.sub.312 249 532943 A G 3 Zn(2)-C6 fungal-type DNA-binding domain CED85099 Y.sub.313 249 598579 C T 2 hypothetical protein CED85125 p.Val310Ile Y.sub.314 249 626627 G A 2 hypothetical protein CED85132 p.Asp723Asn Y.sub.315 249 660408 G A 2 Zn(2)-C6 fungal-type DNA-binding domain CED85144 p.Pro300Ser Y.sub.316 249 854220 G A 2 E3 ubiquitin protein ligase CED85201 p.Leu266Phe Y.sub.317 249 911274 C T 2 Putative transmembrane protein CED85218 p.Thr1003Ile Y.sub.318 249 932606 C T 3 hypothetical protein CED85223 Y.sub.319 249 945434 C T 3 Major facilitator superfamily domain, CED85227 general substrate transporter Y.sub.320 249 945727 C T 3 Major facilitator superfamily domain, CED85227 general substrate transporter Y.sub.321 249 977170 C T 2 protein kinase CED85242 p.Thr32Ile Y.sub.322 249 989520 C T 3 Glucosyltransferase-Alg8p CED85243 Y.sub.323 249 1014098 C T 2 Golgi-associated protein/Nedd4 WW CED85252 p.Val612Ile domain-binding protein Y.sub.324 249 1144309 G A 3 Origin recognition complex, subunit 1, and CED85291 related proteins Y.sub.325 249 1230068 C T 2 cysteine proteinase CED85319 p.Ala803Thr Y.sub.326 249 1619036 G A 2 related to c2h2 zinc finger protein flbc CED85450 p.Asp967Asn Y.sub.327 249 1726777 C T 3 C-14 reductase CED85474 Y.sub.328 249 1803575 C T 2 Hydroxymethylglutaryl-CoA reductase CED85502 p.Pro144Ser Y.sub.329 249 1988505 C T 3 Zn(2)-C6 fungal-type DNA-binding domain CED85560 Y.sub.330 249 2015272 G A 2 RNA polymerase II transcription CED85567 p.Arg120Lys initiation/nucleotide excision repair factor TFIIH, subunit TFB4 Y.sub.331 249 2198205 G A 8 Zn(2)-C6 fungal-type DNA-binding domain CED85628 Y.sub.332 252 512 C T 6 Y.sub.333 252 524 C T 6 Y.sub.334 260 156 G A 6 Y.sub.335 262 30347 G A 2 Microfibrillar-associated protein MFAP1 CDZ98338 p.Glu44Lys Y.sub.336 262 30359 G A 2 Microfibrillar-associated protein MFAP1 CDZ98338 p.Gly48Arg Y.sub.337 262 148151 C T 3 Tetratricopeptide-like helical CDZ98375 Y.sub.338 262 164438 G A 2 hypothetical protein CDZ98383 p.Gly276Glu Y.sub.339 262 201531 G A 8 snf2-family atp dependent chromatin CDZ98396 p.Arg1238Gln remodeling factor snf21 Y.sub.340 262 252708 G A 8 arsenical pump-driving atpase CDZ98414 p.Gly39Asp Y.sub.341 262 380519 C T 4 guanylate kinase CDZ98457 Y.sub.342 262 397539 G A 3 fatty acid-2 hydroxylase CDZ98463 Y.sub.343 262 420102 G A 2 Sucrose transporter and related proteins CDZ98468 p.Thr146Ile Y.sub.344 262 446956 C T 2 RNA polymerase I termination factor, Myb CDZ98477 p.Ala859Val superfamily Y.sub.345 262 557280 G A 2 Uncharacterized conserved protein CDZ98518 p.Gly2213Arg Y.sub.346 262 560713 G A 8 Uncharacterized conserved protein CDZ98519 Y.sub.347 262 562795 C T 2 Ferredoxin/adrenodoxin reductase CDZ98521 p.Gly327Asp Y.sub.348 262 567591 G A 2 wd40 repeat-like protein CDZ98524 p.Pro364Ser Y.sub.349 262 567801 G A 2 wd40 repeat-like protein CDZ98524 p.Pro294Ser Y.sub.350 262 618198 G A 3 Hsp90 co-chaperone CNS1 (contains TPR repeats) CDZ98538 Y.sub.351 262 639962 A G 4 hypothetical protein CDZ98544 Y.sub.352 262 656323 C G 4 RhoGEF GTPase CDZ98545 Y.sub.353 262 668764 C T 3 RhoGEF GTPase CDZ98545 Y.sub.354 262 691577 C T 2 Protein involved in vacuole import and degradation CDZ98551 p.Gly28Arg Y.sub.355 262 822734 G A 2 hypothetical protein CDZ98597 p.Gly184Asp Y.sub.356 262 835874 C T 3 FOG CDZ98601 Y.sub.357 262 865999 G A 3 Mitochondrial Fe2 transporter MMT1 and CDZ98613 related transporters (cation diffusion facilitator superfamily) Y.sub.358 262 971713 G A 3 Glycoside hydrolase, superfamily CDZ98649 Y.sub.359 262 1209662 G A 2 CLASP N-terminal domain CDZ98723 p.Leu48Phe Y.sub.360 262 1226072 C T 2 hypothetical protein CDZ98730 p.Ala131Val Y.sub.361 262 1305361 G A 3 Extracellular matrix glycoprotein Laminin CDZ98753 subunits alpha and gamma Y.sub.362 262 1424293 G A 2 Pinin/SDK/MemA protein CDZ98791 p.Leu131Phe Y.sub.363 262 1455677 G A 5 G protein-coupled receptor, rhodopsin-like CDZ98804 p.Trp395* Y.sub.364 262 1550311 C T 3 Uncharacterized conserved protein CDZ98836 Y.sub.365 262 1615762 G A 2 histone deacetylase clr6 CDZ98855 p.Gly615Glu Y.sub.366 262 1677620 G A 3 Methylase CDZ98873 Y.sub.367 262 1694625 C T 3 RAB proteins geranylgeranyltransferase CDZ98878 component A (RAB escort protein) Y.sub.368 266 252 C T 6
TABLE-US-00014 TABLE 14 Var- Refer- ia- Reference Reference ence Strain Amino Acid tion Scaffold Position Base Base Change Type Impact Gene Classification CDS Change Z.sub.1 Scaffold_262 562795 C T missense_variant MODERATE Ferredoxin/ CDZ98521 p.Gly327Asp adrenodoxin reductase Z.sub.2 Scaffold_52 1399439 G A missense_variant MODERATE Mitochondrial CED83134 p.Arg244Gln cytochrome b2- Z.sub.3 Scaffold_176 358 G A upstream_gene_variant MODIFIER Cytochrome b CED80058 Z.sub.4 Scaffold_22 1643 C T missense_variant MODERATE Cytochrome c oxidase CED80056 p.Leu366Phe subunit 1 Z.sub.5 Scaffold_28 1506 C T missense_variant MODERATE ATP synthase subunit CDZ96150 p.Ala227Val 6 Z.sub.6 Scaffold_43 464 G A missense_variant MODERATE NADH dehydrogenase CDZ96151 p.Thr147Ile subunit 4 Z.sub.7 Scaffold_43 753 C T missense_variant MODERATE NADH dehydrogenase CDZ96151 p.Val51Ile subunit 4 Z.sub.8 Scaffold_62 875 G A missense_variant MODERATE Cytochrome c oxidase CDZ96152 p.Thr110Ile subunit 2 Z.sub.9 Scaffold_102 2334 G A missense_variant MODERATE NADH dehydrogenase CDZ96153 p.Ser181Phe subunits 2, 5, and related proteins Z.sub.10 Scaffold_102 2590 C T missense_variant MODERATE NADH dehydrogenase CDZ96153 p.Ala96Thr subunits 2, 5, and related proteins Z.sub.11 Scaffold_188 815 C T missense_variant MODERATE NADH dehydrogenase CED80060 p.Ala79Val subunit 6 Z.sub.12 Scaffold_247 989 C T missense_variant MODERATE Cytochrome c oxidase CED80061 p.Gly104Glu subunit 3 Z.sub.13 Scaffold_247 1053 G A missense_variant MODERATE Cytochrome c oxidase CED80061 p.Leu83Phe subunit 3 Z.sub.14 Scaffold_52 1399439 G A missense_variant MODERATE Mitochondrial CED83134 p.Arg244Gln cytochrome b2- Z.sub.15 Scaffold_69 384418 G A missense_variant MODERATE Delta 9 fatty acid CED83656 p.Ala149Thr desaturase Z.sub.16 Scaffold_69 865820 C T missense_variant MODERATE Acyl-CoA-oxidase CED83814 p.Leu1253Phe Z.sub.17 Scaffold_79 346823 G A missense_variant MODERATE Pantothenate kinase CDZ96789 p.Gly590Arg PanK and related proteins Z.sub.18 Scaffold_79 1540205 C T missense_variant MODERATE Geranylgeranyl CDZ97186 p.Met237Ile pyrophosphate synthase Z.sub.19 Scaffold_242 233088 G A missense_variant MODERATE fumarate reductase CDZ98193 p.Gly11Glu Z.sub.20 Scaffold_262 420102 G A missense_variant MODERATE Sucrose transporter CDZ98468 p.Thr146Ile and related proteins Z.sub.21 Scaffold_262 562795 C T missense_variant MODERATE Ferredoxin/ CDZ98521 p.Gly327Asp adrenodoxin reductase Z.sub.22 Scaffold_176 358 G A upstream_gene_variant MODIFIER Cytochrome b CED80058 Z.sub.23 Scaffold_32 2438 C T upstream_gene_variant MODIFIER hypothetical protein CDZ96332 Z.sub.24 Scaffold_69 1342909 G A upstream_gene_variant MODIFIER Inositol polyphosphate CED83975 multikinase, component of the ARGR transcription regulatory complex Z.sub.25 Scaffold_262 1455677 G A stop_gained HIGH G protein-coupled CDZ98804 p.Trp395* receptor, rhodopsin- like
TABLE-US-00015 TABLE 15 RS RP Change T GC CDS V.sub.1 Scaffold_262 562795 c.980G > A missense_variant Ferredoxin/adrenodoxin reductase CDZ98521 Scaffold_79 1540205 c.711G > A missense_variant Geranylgeranyl pyrophosphate CDZ97186 synthase Scaffold_242 233088 c.32G > A missense_variant Succinate dehydrogenase CDZ98193 Scaffold_32 2438 c.-9C > T upstream_gene_variant hypothetical protein CDZ96332 Scaffold_176 358 c.-91G > A upstream_gene_variant cytochrome b CED80058 Scaffold_176 1872 c.*923G > A downstream_gene_variant cytochrome b CED80058 Scaffold_176 1980 c.*1031G > A downstream_gene_variant cytochrome b CED80058 Scaffold_179 1525 c.516-188G > A intron_variant NADH:ubiquinone/plastoquinone CDZ96154 oxidoreductase, chain 3 Scaffold_179 1780 c.556 + 27C > T intron_variant NADH:ubiquinone/plastoquinone CDZ96154 oxidoreductase, chain 3 Scaffold_22 1643 c.1096C > T missense_variant cytochrome c oxidase subunit 1 CED80056 Scaffold_22 2524 c.*244G > A downstream_gene_variant cytochrome c oxidase subunit 1 CED80056 Scaffold_62 875 c.329C > T missense_variant cytochrome c oxidase subunit 2 CDZ96152 Scaffold_247 102 c.*598C > T downstream_gene_variant cytochrome c oxidase subunit 3 CED80061 Scaffold_247 989 c.311G > A missense_variant cytochrome c oxidase subunit 3 CED80061 Scaffold_28 236 c.-513G > A upstream_gene_variant atp synthase subunit 6 CDZ96150 Scaffold_28 377 c.-372G > A upstream_gene_variant atp synthase subunit 6 CDZ96150 Scaffold_28 1506 c.680C > T missense_variant atp synthase subunit 6 CDZ96150 Scaffold_28 1677 c.*89C > T downstream_gene_variant atp synthase subunit 6 CDZ96150 Scaffold_42 804 c.*2C > T downstream_gene_variant atp synthase subunit mitochondrial CDZ96333 Scaffold_42 1559 c.*757G > A downstream_gene_variant atp synthase subunit mitochondrial CDZ96333 Scaffold_43 464 c.440C > T missense_variant nadh dehydrogenase subunit 4 CDZ96151 Scaffold_43 753 c.151G > A missense_variant nadh dehydrogenase subunit 4 CDZ96151 Scaffold_43 1527 c.-6246 > A upstream_gene_variant nadb dehydrogenase subunit 4 CDZ96151 Scaffold_43 1748 c.-845C > T upstream_gene_variant nadh dehydrogenase subunit 4 CDZ96151 Scaffold_43 1928 c.-1025G > A upstream_gene_variant nadh dehydrogenase subunit 4 CDZ96151 V.sub.26 Scaffold_247 1053 c.247C > T missense_variant cytochrome c oxidase subunit 3 CED80061
TABLE-US-00016 TABLE 16 log2 (fold CDS Genomic locus change) q value Uniprot ID CED85080 Scaffold_249:455827-456255 9.2956 0.00107 Uniprot/SPTREMBL:A0A0F7SWN7 CDZ98286 Scaffold_242:525123-525779 6.86206 0.00107 Uniprot/SPTREMBL:A0A0F7SHB1 CED84930 Scaffold_249:6618-7695 6.68973 0.00107 Uniprot/SPTREMBL:A0A0F7SWF7 CDZ96332 Scaffold_32:2446-3134 6.52032 0.00107 Uniprot/SPTREMBL:A0A0F7SH35 CED82392 Scaffold_33:1246311-1246833 6.42503 0.00107 Uniprot/SPTREMBL:A0A0F7SJX8 CED82668 Scaffold_52:13001-13910 6.33106 0.00107 Uniprot/SPTREMBL:A0A0F7SRH2 CDZ97516 Scaffold_124:123781-126151 6.23645 0.00107 Uniprot/SPTREMBL:A0A0F7SFE4 CDZ98118 Scaffold_223:211-788 6.11075 0.03259 Uniprot/SPTREMBL:A0A0F7SKA6 CDZ97577 Scaffold_129:458-1082 6.09922 0.0043 Uniprot/SPTREMBL:A0A0F7SKU8 CED85432 Scaffold_249:1559276-1562689 6.02212 0.00107 Uniprot/SPTREMBL:A0A0F7STB7 CDZ96153 Scaffold_102:1486-3157 6.01467 0.00107 Uniprot/SPTREMBL:A0A0F7SF89 CDZ96711 Scaffold_79:125953-127385 5.94901 0.00107 Uniprot/SPTREMBL:A0A0F7SEF7 CED80057 Scaffold_55:626-1151 5.84552 0.0043 Uniprot/SPTREMBL:A0A0F7SIU3 CDZ96413 Scaffold_54:92765-93283 5.60714 0.00107 Uniprot/SPTREMBL:A0A0F7SFN7 CED80056 Scaffold_22:403-2280 5.57479 0.00107 Uniprot/SPTREMBL:A0A0F7SKT4 CDZ98119 Scaffold_232:1114-1783 5.55736 0.00107 Uniprot/SPTREMBL:A0A0F7SKZ2 CED82658 Scaffold_33:2068732-2071114 5.41561 0.00107 Uniprot/SPTREMBL:A0A0F7SRG4 CDZ97957 Scaffold_185:365-1651 5.40013 0.00107 Uniprot/SPTREMBL:A0A0F7SLT0 CED80059 Scaffold_176:1042-1615 5.32443 0.00107 Uniprot/SPTREMBL:A0A0F7SMU1 CDZ96152 Scaffold_62:372-1203 5.30334 0.00107 Uniprot/SPTREMBL:A0A0F7SGI5 CDZ96150 Scaffold_28:748-1588 5.25135 0.00107 Uniprot/SPTREMBL:A0A0F7SEE8 CDZ97807 Scaffold_162:611422-614937 5.25097 0.00107 Uniprot/SPTREMBL:A0A0F7SLF3 CED85517 Scaffold_249:1853363-1853729 5.20577 0.00107 Uniprot/SPTREMBL:A0A0F7STM0 CED80058 Scaffold_176:448-949 5.15189 0.00107 Uniprot/SPTREMBL:A0A0F7SPC4 CED85164 Scaffold_249:714476-715290 5.07079 0.00107 Uniprot/SPTREMBL:A0A0F7SWM1 CED80061 Scaffold_247:699-1383 5.01115 0.00107 Uniprot/SPTREMBL:A0A0F7SKU0 CED80060 Scaffold_188:484-1047 4.99248 0.00107 Uniprot/SPTREMBL:A0A0F7SN33 CDZ96865 Scaffold_79:565627-566760 4.86279 0.00107 Uniprot/SPTREMBL:A0A0F7SF95 CDZ96908 Scaffold_79:687220-687896 4.79852 0.00107 Uniprot/SPTREMBL:A0A0F7SGN7 CDZ96154 Scaffold_179:741-2193 4.72875 0.0043 Uniprot/SPTREMBL:A0A0F7SFY0 CDZ96333 Scaffold_42:183-802 4.64957 0.00107 Uniprot/SPTREMBL:A0A0F7SFK3 CED83979 Scaffold_69:1348663-1349659 4.6261 0.00107 Uniprot/SPTREMBL:A0A0F7STJ2 CED83252 Scaffold_52:1717622-1718044 4.60829 0.00107 Uniprot/SPTREMBL:A0A0F7SMG2 CDZ96608 Scaffold_54:697264-699076 4.57217 0.00107 Uniprot/SPTREMBL:A0A0F7SFX6 CED83097 Scaffold_52:1287383-1290100 4.53939 0.00107 Uniprot/SPTREMBL:A0A0F7SM09 CED84673 Scaffold_78:975769-976045 4.39949 0.00107 Uniprot/SPTREMBL:A0A0F7SX11 CED83815 Scaffold_69:866921-870931 4.33088 0.00107 Uniprot/SPTREMBL:A0A0F7STE4 CED84179 Scaffold_69:1939122-1939368 4.33055 0.00879 Uniprot/SPTREMBL:A0A0F7SU00 CDZ98103 Scaffold_189:441479-441882 4.29543 0.00107 Uniprot/SPTREMBL:A0A0F7SK73 CED84804 Scaffold_78:1364982-1365369 4.25633 0.00107 Uniprot/SPTREMBL:A0A0F7SVT2 CDZ96624 Scaffold_54:747460-747837 4.25212 0.00107 Uniprot/SPTREMBL:A0A0F7SGZ8 CED82344 Scaffold_33:1072903-1074335 4.23726 0.00107 Uniprot/SPTREMBL:A0A0F7SNU8 CDZ96883 Scaffold_79:620425-621230 4.23607 0.00283 Uniprot/SPTREMBL:A0A0F7SGL4 CDZ97379 Scaffold_79:2108930-2109657 4.19032 0.00107 Uniprot/SPTREMBL:A0A0F7SJ70 CDZ98774 Scaffold_262:1369422-1370696 4.17583 0.00107 Uniprot/SPTREMBL:A0A0F7SMU0 CDZ96507 Scaffold_54:383723-384889 4.13638 0.01841 Uniprot/SPTREMBL:A0A0F7SHK0 CDZ98452 Scaffold_262:363391-365724 4.1355 0.00107 Uniprot/SPTREMBL:A0A0F7SMX1 CDZ96151 Scaffold_43:7-903 4.12896 0.00107 Uniprot/SPTREMBL:A0A0F7SE37 CDZ97452 Scaffold_79:2315499-2317423 4.1242 0.00107 Uniprot/SPTREMBL:A0A0F7SKJ4 CED84998 Scaffold_249:216807-219954 4.04803 0.00107 Uniprot/SPTREMBL:A0A0F7SXS0 CED84637 Scaffold_78:884903-885167 3.95039 0.00107 Uniprot/SPTREMBL:A0A0F7SQY4 CDZ97448 Scaffold_79:2302089-2304040 3.94041 0.00107 Uniprot/SPTREMBL:A0A0F7SIB1 CED82193 Scaffold_33:587555-588509 3.91561 0.00107 Uniprot/SPTREMBL:A0A0F7SQ04 CED82352 Scaffold_33:1097639-1100022 3.88483 0.00107 Uniprot/SPTREMBL:A0A0F7SJU9 CDZ96740 Scaffold_79:209909-212506 3.85991 0.00107 Uniprot/SPTREMBL:A0A0F7SF48 CED84786 Scaffold_78:1308664-1311311 3.84158 0.00107 Uniprot/SPTREMBL:A0A0F7STE6 CDZ96633 Scaffold_77:13254-14404 3.73031 0.00107 Uniprot/SPTREMBL:A0A0F7SG10 CED84404 Scaffold_78:150939-152226 3.6789 0.00107 Uniprot/SPTREMBL:A0A0F7SUN7 CDZ97797 Scaffold_162:579804-580834 3.66705 0.00283 Uniprot/SPTREMBL:A0A0F7SLE9 CDZ96601 Scaffold_54:679325-679595 3.62342 0.00107 Uniprot/SPTREMBL:A0A0F7SEC7 CDZ96647 Scaffold_77:41123-42029 3.61574 0.00107 Uniprot/SPTREMBL:A0A0F7SI01 CDZ98284 Scaffold_242:519765-520056 3.58807 0.00107 Uniprot/SPTREMBL:A0A0F7SLM1 CDZ96434 Scaffold_54:155782-156484 3.56523 0.00107 Uniprot/SPTREMBL:A0A0F7SGI3 CED84299 Scaffold_69:2304680-2305552 3.54505 0.00107 Uniprot/SPTREMBL:A0A0F7SUE9 CDZ96748 Scaffold_79:228516-229974 3.54221 0.00107 Uniprot/SPTREMBL:A0A0F7SGA0 CDZ97723 Scaffold_162:378790-379092 3.53675 0.00107 Uniprot/SPTREMBL:A0A0F7SJ97 CED84714 Scaffold_78:1088351-1090512 3.52201 0.01647 Uniprot/SPTREMBL:A0A0F7SVC6 CED85389 Scaffold_249:1437652-1438024 3.48785 0.00635 Uniprot/SPTREMBL:A0A0F7SXD3 CDZ96731 Scaffold_79:178450-181319 3.46595 0.00107 Uniprot/SPTREMBL:A0A0F7SEG4 CDZ97605 Scaffold_162:65-848 3.46476 0.02837 Uniprot/SPTREMBL:A0A0F7SGW0 CDZ96885 Scaffold_79:627282-627758 3.4451 0.00107 Uniprot/SPTREMBL:A0A0F7SFA1 CED82665 Scaffold_52:6245-6725 3.42717 0.00107 Uniprot/SPTREMBL:A0A0F7SQ81 CED82464 Scaffold_33:1468151-1469956 3.40784 0.00572 Uniprot/SPTREMBL:A0A0F7SP15 CED83623 Scaffold_69:281336-282359 3.39893 0.00107 Uniprot/SPTREMBL:A0A0F7SUF7 CDZ97986 Scaffold_189:92376-93295 3.39563 0.00763 Uniprot/SPTREMBL:A0A0F7SGH5 CED84525 Scaffold_78:546343-546634 3.39311 0.04003 Uniprot/SPTREMBL:A0A0F7SVG1 CED83140 Scaffold_52:1417194-1418401 3.36574 0.00107 Uniprot/SPTREMBL:A0A0F7SRK1 CDZ97423 Scaffold_79:2235980-2237243 3.33272 0.04038 Uniprot/SPTREMBL:A0A0F7SI94 CED83508 Scaffold_52:2532580-2533462 3.2865 0.00107 Uniprot/SPTREMBL:A0A0F7SU56 CDZ96639 Scaffold_77:25331-25763 3.27732 0.00107 Uniprot/SPTREMBL:A0A0F7SH10 CED82131 Scaffold_33:407214-418268 3.23793 0.002 Uniprot/SPTREMBL:A0A0F7SL25 CDZ97778 Scaffold_162:523968-524442 3.23551 0.00107 Uniprot/SPTREMBL:A0A0F7SJE9 CDZ97625 Scaffold_162:67635-70853 3.23462 0.00107 Uniprot/SPTREMBL:A0A0F7SGX3 CED83795 Scaffold_69:789151-792032 3.19812 0.00107 Uniprot/SPTREMBL:A0A0F7STA1 CED83831 Scaffold_69:919459-919771 3.18779 0.00107 Uniprot/SPTREMBL:A0A0F7SR09 CED84215 Scaffold_69:2041512-2041896 3.18206 0.00107 Uniprot/SPTREMBL:A0A0F7SUD7 CDZ97534 Scaffold_124:183269-184916 3.17103 0.00107 Uniprot/SPTREMBL:A0A0F7SJL0 CDZ96425 Scaffold_54:135835-138404 3.1657 0.00572 Uniprot/SPTREMBL:A0A0F7SEQ8 CDZ96691 Scaffold_79:68284-68653 3.14581 0.00107 Uniprot/SPTREMBL:A0A0F7SEF0 CDZ96227 Scaffold_24:209321-215733 3.10759 0.00107 Uniprot/SPTREMBL:A0A0F7SGW6 CDZ97639 Scaffold_162:112120-113343 3.09923 0.00107 Uniprot/SPTREMBL:A0A0F7SJT0 CED85588 Scaffold_249:2066996-2068681 3.09682 0.002 Uniprot/SPTREMBL:A0A0F7SZ44 CED82973 Scaffold_52:935660-938515 3.08913 0.03157 Uniprot/SPTREMBL:A0A0F7SSD6 CED85285 Scaffold_249:1122388-1123094 3.0859 0.02777 Uniprot/SPTREMBL:A0A0F7SXA0 CDZ96723 Scaffold_79:158597-160262 3.05802 0.00107 Uniprot/SPTREMBL:A0A0F7SG83 CED85248 Scaffold_249:999627-1000271 3.04686 0.00818 Uniprot/SPTREMBL:A0A0F7SYB5 CED84711 Scaffold_78:1081064-1082458 3.03732 0.00107 Uniprot/SPTREMBL:A0A0F7ST85 CED84955 Scaffold_249:76786-77647 3.03601 0.002 Uniprot/SPTREMBL:A0A0F7SWH0 CDZ96974 Scaffold_79:897858-899128 3.01336 0.00107 Uniprot/SPTREMBL:A0A0F7SI66 CED82598 Scaffold_33:1903939-1904188 3.00633 0.00697 Uniprot/SPTREMBL:A0A0F7SRB7 CDZ97694 Scaffold_162:285211-285769 2.98783 0.00107 Uniprot/SPTREMBL:A0A0F7SK35 CDZ97736 Scaffold_162:413045-414204 2.98331 0.00107 Uniprot/SPTREMBL:A0A0F7SFV1 CDZ96625 Scaffold_63:96-1049 2.97684 0.026 Uniprot/SPTREMBL:A0A0F7SEZ4 CDZ97068 Scaffold_79:1181236-1182652 2.93609 0.00107 Uniprot/SPTREMBL:A0A0F7SH49 CDZ97420 Scaffold_79:2229810-2232473 2.93301 0.0139 Uniprot/SPTREMBL:A0A0F7SG73 CED85140 Scaffold_249:646783-648424 2.92845 0.00635 Uniprot/SPTREMBL:A0A0F7SWV9 CDZ97946 Scaffold_162:1032808-1037153 2.91654 0.00107 Uniprot/SPTREMBL:A0A0F7SGD0 CDZ98244 Scaffold_242:394144-394730 2.91373 0.00763 Uniprot/SPTREMBL:A0A0F7SLI0 CED83041 Scaffold_52:1131882-1133579 2.91355 0.00107 Uniprot/SPTREMBL:A0A0F7SNP9 CED85485 Scaffold_249:1757631-1758380 2.9125 0.03701 Uniprot/SPTREMBL:A0A0F7SY71 CDZ96603 Scaffold_54:684615-686836 2.86775 0.00107 Uniprot/SPTREMBL:A0A0F7SFX2 CED85448 Scaffold_249:1609292-1610258 2.86226 0.01647 Uniprot/SPTREMBL:A0A0F7SYS0 CDZ96340 Scaffold_53:5356-7165 2.86174 0.00107 Uniprot/SPTREMBL:A0A0F7SEM7 CDZ97752 Scaffold_162:456053-456784 2.8593 0.01003 Uniprot/SPTREMBL:A0A0F7SLC8 CDZ96938 Scaffold_79:794992-795565 2.85559 0.00107 Uniprot/SPTREMBL:A0A0F7SGR2 CED84750 Scaffold_78:1210728-1211551 2.84262 0.01157 Uniprot/SPTREMBL:A0A0F7SVW4 CED84654 Scaffold_78:929313-930567 2.83588 0.0421 Uniprot/SPTREMBL:A0A0F7SV72 CED84929 Scaffold_249:1542-2672 2.82389 0.03333 Uniprot/SPTREMBL:A0A0F7SW16 CED85266 Scaffold_249:1061106-1062657 2.81591 0.03435 Uniprot/SPTREMBL:A0A0F7SUQ5 CED83544 Scaffold_69:53167-54761 2.81175 0.02802 Uniprot/SPTREMBL:A0A0F7SSD9 CED83430 Scaffold_52:2282025-2284655 2.81037 0.00107 Uniprot/SPTREMBL:A0A0F7SSA2 CDZ97896 Scaffold_162:885528-888251 2.8087 0.00107 Uniprot/SPTREMBL:A0A0F7SG99 CDZ98193 Scaffold_242:233056-236702 2.80059 0.00107 Uniprot/SPTREMBL:A0A0F7SKM1 CDZ96546 Scaffold_54:514464-515814 2.79309 0.01003 Uniprot/SPTREMBL:A0A0F7SEB6 CED82513 Scaffold_33:1637082-1638403 2.78715 0.04003 Uniprot/SPTREMBL:A0A0F7SR22 CDZ98764 Scaffold_262:1341690-1344148 2.77661 0.00107 Uniprot/SPTREMBL:A0A0F7SMT3 CED83907 Scaffold_69:1129431-1131705 2.76752 0.01794 Uniprot/SPTREMBL:A0A0F7SP83 CED82580 Scaffold_33:1852517-1855025 2.76238 0.00107 Uniprot/SPTREMBL:A0A0F7SQ15 CED83518 Scaffold_52:2553963-2555767 2.743 0.03229 Uniprot/SPTREMBL:A0A0F7SU60 CDZ97921 Scaffold_162:964515-965232 2.71423 0.00107 Uniprot/SPTREMBL:A0A0F7SGB4 CED85536 Scaffold_249:1908367-1911501 2.71336 0.00107 Uniprot/SPTREMBL:A0A0F7SVG2 CDZ97601 Scaffold_155:195-516 2.70857 0.03157 Uniprot/SPTREMBL:A0A0F7SFL1 CDZ96325 Scaffold_24:506034-507436 2.69145 0.00283 Uniprot/SPTREMBL:A0A0F7SEM4 CDZ97097 Scaffold_79:1257573-1259549 2.67196 0.04565 Uniprot/SPTREMBL:A0A0F7SJC9 CED85390 Scaffold_249:1438192-1439158 2.66706 0.03435 Uniprot/SPTREMBL:A0A0F7SXN7 CED85516 Scaffold_249:1850199-1853329 2.65919 0.00107 Uniprot/SPTREMBL:A0A0F7SVE4 CED83983 Scaffold_69:1358613-1359556 2.64233 0.00107 Uniprot/SPTREMBL:A0A0F7SVK0 CDZ98301 Scaffold_242:578537-580259 2.63598 0.00107 Uniprot/SPTREMBL:A0A0F7SHC5 CED84180 Scaffold_69:1939424-1940850 2.63185 0.02306 Uniprot/SPTREMBL:A0A0F7SUC0 CED85339 Scaffold_249:1288096-1288987 2.63024 0.00879 Uniprot/SPTREMBL:A0A0F7SXB4 CED83447 Scaffold_52:2325373-2326346 2.60976 0.00635 Uniprot/SPTREMBL:A0A0F7SN08 CDZ98703 Scaffold_262:1147976-1153160 2.60584 0.00572 Uniprot/SPTREMBL:A0A0F7SM10 CED83390 Scaffold_52:2154690-2155940 2.57361 0.00107 Uniprot/SPTREMBL:A0A0F7SS86 CED85564 Scaffold_249:2007538-2009056 2.56166 0.00107 Uniprot/SPTREMBL:A0A0F7SXT5 CED85596 Scaffold_249:2088847-2090119 2.55839 0.02962 Uniprot/SPTREMBL:A0A0F7SVL0 CDZ96960 Scaffold_79:859494-860819 2.55825 0.02443 Uniprot/SPTREMBL:A0A0F7SFD1 CED83901 Scaffold_69:1112099-1112693 2.55723 0.00107 Uniprot/SPTREMBL:A0A0F7SR75 CDZ96968 Scaffold_79:880554-881657 2.55571 0.00107 Uniprot/SPTREMBL:A0A0F7SGU9 CDZ97756 Scaffold_162:463549-466940 2.55281 0.00107 Uniprot/SPTREMBL:A0A0F7SFY6 CED84981 Scaffold_249:153000-155119 2.54954 0.00635 Uniprot/SPTREMBL:A0A0F7SU30 CDZ96256 Scaffold_24:312616-313991 2.54133 0.00107 Uniprot/SPTREMBL:A0A0F7SE58 CED84768 Scaffold_78:1260836-1261396 2.53828 0.00107 Uniprot/SPTREMBL:A0A0F7SX63 CDZ97720 Scaffold_162:372745-373132 2.53182 0.00107 Uniprot/SPTREMBL:A0A0F7SH84 CDZ96462 Scaffold_54:239487-240962 2.52853 0.03333 Uniprot/SPTREMBL:A0A0F7SHG2 CDZ96308 Scaffold_24:471561-474813 2.51609 0.03435 Uniprot/SPTREMBL:A0A0F7SFJ8 CDZ96398 Scaffold_54:48224-49552 2.51507 0.00107 Uniprot/SPTREMBL:A0A0F7SFM9 CED84125 Scaffold_69:1789791-1791079 2.51267 0.00107 Uniprot/SPTREMBL:A0A0F7SUA0 CED82597 Scaffold_33:1901063-1903830 2.51046 0.00107 Uniprot/SPTREMBL:A0A0F7SKE3 CDZ96812 Scaffold_79:415347-415957 2.50562 0.00358 Uniprot/SPTREMBL:A0A0F7SIN5 CED85214 Scaffold_249:894511-897801 2.4834 0.00107 Uniprot/SPTREMBL:A0A0F7SWT8 CED83935 Scaffold_69:1212340-1212580 2.44459 0.00879 Uniprot/SPTREMBL:A0A0F7STN4 CDZ96565 Scaffold_54:557265-562538 2.44098 0.00107 Uniprot/SPTREMBL:A0A0F7SEY2 CDZ96800 Scaffold_79:377379-378952 2.43835 0.03632 Uniprot/SPTREMBL:A0A0F7SF69 CDZ97029 Scaffold_79:1059984-1060272 2.43064 0.02802 Uniprot/SPTREMBL:A0A0F7SI95 CDZ97443 Scaffold_79:2290162-2292224 2.41806 0.02473 Uniprot/SPTREMBL:A0A0F7SIA8 CED83766 Scaffold_69:691513-694257 2.41186 0.00358 Uniprot/SPTREMBL:A0A0F7SQQ1 CDZ97945 Scaffold_162:1031822-1032537 2.40755 0.02802 Uniprot/SPTREMBL:A0A0F7SHT1 CDZ96911 Scaffold_79:690843-693362 2.38478 0.00107 Uniprot/SPTREMBL:A0A0F7SEN6 CDZ98503 Scaffold_262:516975-517254 2.38051 0.00358 Uniprot/SPTREMBL:A0A0F7SLD8 CED84099 Scaffold_69:1712578-1712954 2.37587 0.00107 Uniprot/SPTREMBL:A0A0F7STV4 CDZ97312 Scaffold_79:1919826-1920493 2.37313 0.00107 Uniprot/SPTREMBL:A0A0F7SK29 CED82663 Scaffold_33:2085699-2086479 2.36106 0.00107 Uniprot/SPTREMBL:A0A0F7SRG7 CED84677 Scaffold_78:988591-991029 2.35953 0.00107 Uniprot/SPTREMBL:A0A0F7SR25 CED83843 Scaffold_69:952349-955303 2.35584 0.00818 Uniprot/SPTREMBL:A0A0F7SV82 CED82395 Scaffold_33:1255820-1258390 2.35553 0.00107 Uniprot/SPTREMBL:A0A0F7SPH8 CED85400 Scaffold_249:1464663-1466595 2.35205 0.00107 Uniprot/SPTREMBL:A0A0F7SXS5 CED82482 Scaffold_33:1524955-1525327 2.33456 0.00107 Uniprot/SPTREMBL:A0A0F7SK45 CED82114 Scaffold_33:344547-346439 2.33295 0.00107 Uniprot/SPTREMBL:A0A0F7SN68 CDZ96998 Scaffold_79:961487-962221 2.33028 0.00283 Uniprot/SPTREMBL:A0A0F7SH05 CDZ96634 Scaffold_77:15676-16842 2.32402 0.00107 Uniprot/SPTREMBL:A0A0F7SH06 CDZ98558 Scaffold_262:709808-712125 2.31029 0.00107 Uniprot/SPTREMBL:A0A0F7SLI7 CED85083 Scaffold_249:460456-461478 2.30642 0.02919 Uniprot/SPTREMBL:A0A0F7SXY0 CDZ96978 Scaffold_79:911819-914066 2.2979 0.03435 Uniprot/SPTREMBL:A0A0F7SGV8 CDZ97884 Scaffold_162:847559-849948 2.28895 0.02473 Uniprot/SPTREMBL:A0A0F7SKD6 CED83769 Scaffold_69:699438-701924 2.28794 0.00107 Uniprot/SPTREMBL:A0A0F7SSZ9 CED85326 Scaffold_249:1257258-1258493 2.2837 0.00107 Uniprot/SPTREMBL:A0A0F7SUY7 CDZ96782 Scaffold_79:323429-325820 2.27037 0.00107 Uniprot/SPTREMBL:A0A0F7SIK6 CDZ97481 Scaffold_124:7774-13138 2.25897 0.0043 Uniprot/SPTREMBL:A0A0F7SFC7 CED85048 Scaffold_249:370221-371540 2.25614 0.00697 Uniprot/SPTREMBL:A0A0F7SXU8 CED85332 Scaffold_249:1271082-1271657 2.24969 0.02351 Uniprot/SPTREMBL:A0A0F7ST43 CED82842 Scaffold_52:560142-562537 2.24235 0.04884 Uniprot/SPTREMBL:A0A0F7SL74 CDZ96732 Scaffold_79:181587-183236 2.23715 0.00107 Uniprot/SPTREMBL:A0A0F7SIG1 CED83940 Scaffold_69:1230023-1233189 2.23141 0.00572 Uniprot/SPTREMBL:Q3HR17 CDZ98646 Scaffold_262:962599-964005 2.22002 0.00107 Uniprot/SPTREMBL:A0A0F7SI49 CED84596 Scaffold_78:751045-752053 2.21506 0.00107 Uniprot/SPTREMBL:A0A0F7ST01 CED84309 Scaffold_69:2328564-2329971 2.18139 0.00818 Uniprot/SPTREMBL:A0A0F7SUF6 CED85421 Scaffold_249:1522642-1523545 2.1799 0.00107 Uniprot/SPTREMBL:A0A0F7SV61 CDZ96632 Scaffold_77:12435-12783 2.17855 0.02637 Uniprot/SPTREMBL:A0A0F7SHY4 CED82055 Scaffold_33:159801-160443 2.16592 0.00107 Uniprot/SPTREMBL:A0A0F7SN80 CED84932 Scaffold_249:11741-12335 2.15937 0.00107 Uniprot/SPTREMBL:A0A0F7SRU4 CED83176 Scaffold_52:1503852-1505330 2.15895 0.00107 Uniprot/SPTREMBL:A0A0F7SP03 CED85184 Scaffold_249:785518-789209 2.15362 0.00107 Uniprot/SPTREMBL:A0A0F7SWN9 CED83158 Scaffold_52:1456975-1458575 2.15067 0.01101 Uniprot/SPTREMBL:A0A0F7SSX2 CED84360 Scaffold_78:4618-6613 2.14217 0.00107 Uniprot/SPTREMBL:A0A0F7SV22 CDZ96606 Scaffold_54:691857-692139 2.13837 0.03188 Uniprot/SPTREMBL:A0A0F7SEC8 CDZ98281 Scaffold_242:511970-514140 2.12939 0.03362 Uniprot/SPTREMBL:A0A0F7SHA8 CED83450 Scaffold_52:2332008-2335986 2.12535 0.00107 Uniprot/SPTREMBL:A0A0F7SSD2 CDZ96255 Scaffold_24:304621-312364 2.12075 0.00107 Uniprot/SPTREMBL:A0A0F7SEK2 CED84965 Scaffold_249:100476-100977 2.12015 0.02687 Uniprot/SPTREMBL:A0A0F7SWH8 CED83977 Scaffold_69:1344500-1346015 2.11941 0.03518 Uniprot/SPTREMBL:A0A0F7SPB1 CDZ96598 Scaffold_54:674693-675994 2.11801 0.002 Uniprot/SPTREMBL:A0A0F7SFW9 CED85198 Scaffold_249:838732-840721 2.11044 0.0431 Uniprot/SPTREMBL:A0A0F7SY45 CDZ98037 Scaffold_189:240085-243335 2.1099 0.0367 Uniprot/SPTREMBL:A0A0F7SM63 CED84166 Scaffold_69:1902914-1907183 2.10358 0.00107 Uniprot/SPTREMBL:A0A0F7SRS9 CDZ96253 Scaffold_24:294036-295659 2.09696 0.00107 Uniprot/SPTREMBL:A0A0F7SFH1 CDZ96587 Scaffold_54:635972-638782 2.07411 0.00283 Uniprot/SPTREMBL:A0A0F7SHU1 CDZ97406 Scaffold_79:2190879-2192026 2.06531 0.01217 Uniprot/SPTREMBL:A0A0F7SF75 CED82118 Scaffold_33:355172-355794 2.06453 0.00107 Uniprot/SPTREMBL:A0A0F7SPR7 CED84712 Scaffold_78:1082888-1085081 2.04606 0.00107 Uniprot/SPTREMBL:A0A0F7SR59 CED83235 Scaffold_52:1658608-1660253 2.03709 0.02837 Uniprot/SPTREMBL:A0A0F7SRX7 CDZ96808 Scaffold_79:402194-403759 2.01274 0.00107 Uniprot/SPTREMBL:A0A0F7SGF8 CED84189 Scaffold_69:1965278-1968656 2.00903 0.00107 Uniprot/SPTREMBL:A0A0F7SU09 CDZ96972 Scaffold_79:892224-894290 2.00813 0.00107 Uniprot/SPTREMBL:A0A0F7SJ16 CDZ98157 Scaffold_242:119690-120995 2.00799 0.01157 Uniprot/SPTREMBL:A0A0F7SMG5 CED85202 Scaffold_249:856230-864330 2.00782 0.00107 Uniprot/SPTREMBL:A0A0F7SSN3 CDZ97710 Scaffold_162:350139-350415 2.00424 0.00697 Uniprot/SPTREMBL:A0A0F7SH77 CED82504 Scaffold_33:1607291-1608419 2.0026 0.00107 Uniprot/SPTREMBL:A0A0F7SP52 CDZ98740 Scaffold_262:1258470-1261686 2.00231 0.00107 Uniprot/SPTREMBL:A0A0F7SK26 CDZ98359 Scaffold_262:82976-84729 1.99765 0.01794 Uniprot/SPTREMBL:A0A0F7SLU2 CED84345 Scaffold_69:2445860-2450055 1.99755 0.00107 Uniprot/SPTREMBL:A0A0F7SV09 CDZ96501 Scaffold_54:372224-373353 1.99602 0.00635 Uniprot/SPTREMBL:A0A0F7SEA7 CED84559 Scaffold_78:652640-653728 1.99303 0.00107 Uniprot/SPTREMBL:A0A0F7SUY8 CED82642 Scaffold_33:2021875-2023953 1.98413 0.00107 Uniprot/SPTREMBL:A0A0F7SKH3 CED82491 Scaffold_33:1571741-1572704 1.96965 0.00107 Uniprot/SPTREMBL:A0A0F7SM44 CDZ98294 Scaffold_242:549453-552382 1.96744 0.01332 Uniprot/SPTREMBL:A0A0F7SLM8 CDZ96892 Scaffold_79:643491-645980 1.96608 0.00107 Uniprot/SPTREMBL:A0A0F7SIU6 CED82781 Scaffold_52:377187-379075 1.96467 0.03632 Uniprot/SPTREMBL:A0A0F7SMZ9 CED84469 Scaffold_78:379871-381445 1.96299 0.0161 Uniprot/SPTREMBL:A0A0F7SUT6 CED83869 Scaffold_69:1022462-1022876 1.9615 0.02177 Uniprot/SPTREMBL:A0A0F7STC4 CDZ98639 Scaffold_262:942397-945182 1.96071 0.00697 Uniprot/SPTREMBL:A0A0F7SMC3 CED82294 Scaffold_33:915824-923046 1.95891 0.00107 Uniprot/SPTREMBL:A0A0F7SNM9 CDZ98287 Scaffold_242:526295-527209 1.95446 0.01694 Uniprot/SPTREMBL:A0A0F7SMN1 CDZ98041 Scaffold_189:257441-258978 1.95439 0.00358 Uniprot/SPTREMBL:A0A0F7SGM4 CDZ96788 Scaffold_79:341612-343354 1.95437 0.03157 Uniprot/SPTREMBL:A0A0F7SGC5 CDZ97716 Scaffold_162:364590-367041 1.95203 0.00107 Uniprot/SPTREMBL:A0A0F7SFU3 CED83610 Scaffold_69:242322-244080 1.92797 0.00107 Uniprot/SPTREMBL:A0A0F7SST7 CDZ96286 Scaffold_24:397274-398963 1.92503 0.00107 Uniprot/SPTREMBL:A0A0F7SE64 CED84538 Scaffold_78:578277-581045 1.90782 0.03932 Uniprot/SPTREMBL:A0A0F7SWS5 CED84356 Scaffold_69:2490030-2490654 1.90252 0.00107 Uniprot/SPTREMBL:A0A0F7SS99 CED85504 Scaffold_249:1810396-1812070 1.90035 0.00358 Uniprot/SPTREMBL:A0A0F7SXP5 CED82460 Scaffold_33:1453523-1455238 1.89525 0.00107 Uniprot/SPTREMBL:A0A0F7SPP5 CED82775 Scaffold_52:362164-364734 1.89452 0.00283 Uniprot/SPTREMBL:A0A0F7SQD0 CED83321 Scaffold_52:1931031-1933041 1.88777 0.002 Uniprot/SPTREMBL:A0A0F7SPI4 CDZ96906 Scaffold_79:681395-683346 1.88628 0.01694 Uniprot/SPTREMBL:A0A0F7SEN4 CED84096 Scaffold_69:1707265-1708032 1.88125 0.0161 Uniprot/SPTREMBL:A0A0F7SRN0 CED85628 Scaffold_249:2197535-2201856 1.8811 0.00107 Uniprot/SPTREMBL:A0A0F7SZ68 CED82156 Scaffold_33:478691-480487 1.88089 0.0043 Uniprot/SPTREMBL:A0A0F7SL33 CDZ96504 Scaffold_54:378291-378717 1.88061 0.00283 Uniprot/SPTREMBL:A0A0F7SGP6 CED85328 Scaffold_249:1262299-1263857 1.87508 0.0043 Uniprot/SPTREMBL:A0A0F7SYK9 CED83818 Scaffold_69:877698-879991 1.86052 0.00107 Uniprot/SPTREMBL:A0A0F7SV21 CDZ97194 Scaffold_79:1560834-1562423 1.84772 0.0043 Uniprot/SPTREMBL:A0A0F7SIN2 CDZ98812 Scaffold_262:1476547-1477648 1.84706 0.00697 Uniprot/SPTREMBL:A0A0F7SP59 CDZ97787 Scaffold_162:549563-550935 1.83915 0.00107 Uniprot/SPTREMBL:A0A0F7SLE1 CDZ98454 Scaffold_262:367663-368762 1.83557 0.04815 Uniprot/SPTREMBL:A0A0F7SLZ5 CED83570 Scaffold_69:136793-137232 1.83385 0.00763 Uniprot/SPTREMBL:A0A0F7SSP1 CDZ98779 Scaffold_262:1387128-1388066 1.83114 0.02143 Uniprot/SPTREMBL:A0A0F7SMW1 CED82892 Scaffold_52:712686-713696 1.82093 0.002 Uniprot/SPTREMBL:A0A0F7SLA9 CDZ98620 Scaffold_262:884277-885713 1.82088 0.00107 Uniprot/SPTREMBL:A0A0F7SJJ9 CED84456 Scaffold_78:343882-347639 1.80468 0.00107 Uniprot/SPTREMBL:A0A0F7SSL8 CED85327 Scaffold_249:1258917-1262061 1.79428 0.00107 Uniprot/SPTREMBL:A0A0F7ST41 CED83941 Scaffold_69:1233633-1235992 1.7932 0.00107 Uniprot/SPTREMBL:A0A0F7SRB6 CED82524 Scaffold_33:1668538-1669641 1.79313 0.04455 Uniprot/SPTREMBL:A0A0F7SP69 CED85282 Scaffold_249:1112034-1112403 1.79149 0.00107 Uniprot/SPTREMBL:A0A0F7SSW3 CED84172 Scaffold_69:1923729-1924227 1.7889 0.01101 Uniprot/SPTREMBL:A0A0F7SPM4 CDZ96439 Scaffold_54:171347-173858 1.78847 0.00107 Uniprot/SPTREMBL:A0A0F7SGI8 CDZ96760 Scaffold_79:261484-264763 1.78807 0.0043 Uniprot/SPTREMBL:A0A0F7SF56 CDZ97680 Scaffold_162:241932-249389 1.78266 0.00107 Uniprot/SPTREMBL:A0A0F7SH15 CED83749 Scaffold_69:647207-648008 1.7682 0.00763 Uniprot/SPTREMBL:A0A0F7SSY3 CED84996 Scaffold_249:211362-212285 1.76735 0.01647 Uniprot/SPTREMBL:A0A0F7SU50 CDZ97494 Scaffold_124:53255-54125 1.76701 0.01332 Uniprot/SPTREMBL:A0A0F7SJH9 CDZ98520 Scaffold_262:561685-561949 1.76251 0.03739 Uniprot/SPTREMBL:A0A0F7SJA9 CED82328 Scaffold_33:1021691-1022108 1.76246 0.00107 Uniprot/SPTREMBL:A0A0F7SQL5 CDZ97939 Scaffold_162:1013551-1014587 1.75145 0.002 Uniprot/SPTREMBL:A0A0F7SKJ1 CDZ96930 Scaffold_79:746360-747555 1.75114 0.00572 Uniprot/SPTREMBL:A0A0F7SFC1 CED82946 Scaffold_52:860371-866416 1.74633 0.00283 Uniprot/SPTREMBL:A0A0F7SNI9 CED83711 Scaffold_69:554013-556123 1.74598 0.00107 Uniprot/SPTREMBL:A0A0F7SQJ8 CED82123 Scaffold_33:388987-389410 1.74366 0.01053 Uniprot/SPTREMBL:A0A0F7SPS1 CED82360 Scaffold_33:1130243-1130913 1.73312 0.00107 Uniprot/SPTREMBL:A0A0F7SPF3 CDZ97779 Scaffold_162:525829-527237 1.733 0.01694 Uniprot/SPTREMBL:A0A0F7SK88 CED85569 Scaffold_249:2019949-2021723 1.72317 0.01945 Uniprot/SPTREMBL:A0A0F7SXT8 CED83436 Scaffold_52:2300030-2305206 1.71845 0.0431 Uniprot/SPTREMBL:A0A0F7SPX5 CDZ98665 Scaffold_262:1028338-1030601 1.71812 0.00358 Uniprot/SPTREMBL:A0A0F7SJN5 CED85020 Scaffold_249:296664-298545 1.71623 0.01157 Uniprot/SPTREMBL:A0A0F7SWL0 CED84604 Scaffold_78:779180-781208 1.71439 0.00107 Uniprot/SPTREMBL:A0A0F7SV30 CED82780 Scaffold_52:376708-377149 1.70936 0.02871 Uniprot/SPTREMBL:A0A0F7SQD4 CDZ97281 Scaffold_79:1836628-1840608 1.69661 0.00107 Uniprot/SPTREMBL:A0A0F7SF24 CED83439 Scaffold_52:2309892-2311510 1.69193 0.02637 Uniprot/SPTREMBL:A0A0F7SS19 CED82079 Scaffold_33:239200-241650 1.69016 0.002 Uniprot/SPTREMBL:A0A0F7SN39 CDZ98224 Scaffold_242:327901-329763 1.68977 0.04003 Uniprot/SPTREMBL:A0A0F7SLH2 CED82722 Scaffold_52:182117-184588 1.68822 0.00107 Uniprot/SPTREMBL:A0A0F7SKP4 CDZ97375 Scaffold_79:2093793-2097753 1.68491 0.02103 Uniprot/SPTREMBL:A0A0F7SG41 CDZ97123 Scaffold_79:1339460-1339748 1.67557 0.00879 Uniprot/SPTREMBL:A0A0F7SH81 CED84572 Scaffold_78:691147-691673 1.6727 0.03932 Uniprot/SPTREMBL:A0A0F7SQS5 CDZ97512 Scaffold_124:111983-114421 1.65771 0.00283 Uniprot/SPTREMBL:A0A0F7SKN5 CED85019 Scaffold_249:294296-296444 1.65616 0.00283 Uniprot/SPTREMBL:A0A0F7SW64 CED82324 Scaffold_33:1008644-1009307 1.65351 0.04494 Uniprot/SPTREMBL:A0A0F7SNU0 CED82508 Scaffold_33:1616764-1620298 1.65261 0.02995 Uniprot/SPTREMBL:A0A0F7SR17 CDZ97693 Scaffold_162:282885-284685 1.6427 0.04565 Uniprot/SPTREMBL:A0A0F7SJ63 CED82289 Scaffold_33:901370-903029 1.64196 0.02177 Uniprot/SPTREMBL:A0A0F7SNM3 CED83145 Scaffold_52:1426474-1427363 1.63568 0.00501 Uniprot/SPTREMBL:A0A0F7SRK6 CED85454 Scaffold_249:1633248-1635799 1.63511 0.01053 Uniprot/SPTREMBL:A0A0F7SXI7 CED82385 Scaffold_33:1213652-1214862 1.63026 0.00107 Uniprot/SPTREMBL:A0A0F7SPH1 CED85322 Scaffold_249:1240882-1244102 1.62685 0.00107 Uniprot/SPTREMBL:A0A0F7ST39 CED84535 Scaffold_78:571126-573958 1.62373 0.00107 Uniprot/SPTREMBL:A0A0F7SVH0 CED84214 Scaffold_69:2039858-2041252 1.61855 0.00283 Uniprot/SPTREMBL:A0A0F7SU34 CDZ98683 Scaffold_262:1084236-1085358 1.61606 0.03299 Uniprot/SPTREMBL:A0A0F7SLR4 CDZ96646 Scaffold_77:37852-39974 1.61544 0.0412 Uniprot/SPTREMBL:A0A0F7SED6 CDZ97655 Scaffold_162:169391-171313 1.61044 0.00107 Uniprot/SPTREMBL:A0A0F7SGZ1 CED82435 Scaffold_33:1375657-1376321 1.60294 0.03362 Uniprot/SPTREMBL:A0A0F7SPL1 CDZ96353 Scaffold_53:39630-41165 1.60113 0.01332 Uniprot/SPTREMBL:A0A0F7SFK7 CED85316 Scaffold_249:1219985-1222284 1.5994 0.00107 Uniprot/SPTREMBL:A0A0F7SUY1 CED85551 Scaffold_249:1966372-1966880 1.5983 0.02306 Uniprot/SPTREMBL:A0A0F7SVH5 CED82905 Scaffold_52:739430-741872 1.5972 0.00283 Uniprot/SPTREMBL:A0A0F7SQX4 CED82119 Scaffold_33:356446-357504 1.59584 0.02777 Uniprot/SPTREMBL:A0A0F7SN74 CDZ97090 Scaffold_79:1242177-1243818 1.58623 0.00358 Uniprot/SPTREMBL:A0A0F7SFM3 CDZ98290 Scaffold_242:536964-539211 1.58604 0.00107 Uniprot/SPTREMBL:A0A0F7SIT5 CDZ97832 Scaffold_162:704190-706731 1.58336 0.02802 Uniprot/SPTREMBL:A0A0F7SLG7 CED85078 Scaffold_249:452193-453817 1.58042 0.00572 Uniprot/SPTREMBL:A0A0F7SXX7 CDZ97342 Scaffold_79:2008848-2011495 1.57743 0.00358 Uniprot/SPTREMBL:A0A0F7SKA1 CDZ98442 Scaffold_262:332477-334363 1.57599 0.00107 Uniprot/SPTREMBL:A0A0F7SMW0 CDZ98586 Scaffold_262:790738-792475 1.57232 0.036 Uniprot/SPTREMBL:A0A0F7SHZ1 CDZ96795 Scaffold_79:367786-368691 1.57118 0.00107 Uniprot/SPTREMBL:A0A0F7SF68 CED84312 Scaffold_69:2335968-2339524 1.56304 0.00107 Uniprot/SPTREMBL:A0A0F7SQ38 CED85566 Scaffold_249:2010817-2014453 1.56205 0.00818 Uniprot/SPTREMBL:A0A0F7SVJ0 CDZ96533 Scaffold_54:469308-470639 1.54987 0.00107 Uniprot/SPTREMBL:A0A0F7SFT7 CED83799 Scaffold_69:806596-808829 1.54674 0.01555 Uniprot/SPTREMBL:A0A0F7ST65 CDZ97301 Scaffold_79:1895673-1899713 1.54005 0.00107 Uniprot/SPTREMBL:A0A0F7SF28 CDZ98863 Scaffold_262:1643499-1645000 1.53807 0.015 Uniprot/SPTREMBL:A0A0F7SMR4 CDZ97626 Scaffold_162:72630-75282 1.53645 0.02871 Uniprot/SPTREMBL:A0A0F7SFM5 CED85634 Scaffold_249:2227699-2228797 1.53581 0.00107 Uniprot/SPTREMBL:A0A0F7SXX2 CED85324 Scaffold_249:1248991-1251887 1.53192 0.02802 Uniprot/SPTREMBL:A0A0F7SXA4 CED82417 Scaffold_33:1319300-1322122 1.53133 0.04244 Uniprot/SPTREMBL:A0A0F7SJZ6 CDZ97678 Scaffold_162:232784-241715 1.52463 0.0043 Uniprot/SPTREMBL:A0A0F7SIX8 CDZ96274 Scaffold_24:357108-358373 1.51225 0.005005 Uniprot/SPTREMBL:A0A0F7SG98 CDZ98521 Scaffold_262:562010-563865 1.50923 0.043893 Uniprot/SPTREMBL:A0A0F7SHS8 CDZ98400 Scaffold_262:210340-212288 1.50678 0.021773 Uniprot/SPTREMBL:A0A0F7SJ22 CED83916 Scaffold_69:1154024-1156799 1.50497 0.001074 Uniprot/SPTREMBL:A0A0F7SR83 CDZ96728 Scaffold_79:169536-171538 1.50386 0.001074 Uniprot/SPTREMBL:A0A0F7SG87 CED84058 Scaffold_69:1585666-1587120 1.50001 0.04038 Uniprot/SPTREMBL:A0A0F7SVP8 CDZ97260 Scaffold_79:1781498-1784170 1.49942 0.001074 Uniprot/SPTREMBL:A0A0F7SFY9 CDZ98006 Scaffold_189:153436-154789 1.49578 0.011005 Uniprot/SPTREMBL:A0A0F7SGJ4 CDZ97704 Scaffold_162:327605-328202 1.49284 0.023995 Uniprot/SPTREMBL:A0A0F7SK48 CED85192 Scaffold_249:819695-822477 1.47714 0.001074 Uniprot/SPTREMBL:A0A0F7SSM3 CED82260 Scaffold_33:802880-804905 1.47606 0.001074 Uniprot/SPTREMBL:A0A0F7SNS6 CDZ96526 Scaffold_54:453538-454510 1.47498 0.001074 Uniprot/SPTREMBL:A0A0F7SEB2 CED85479 Scaffold_249:1739097-1739458 1.46899 0.036699 Uniprot/SPTREMBL:A0A0F7SXK3 CDZ97261 Scaffold_79:1784392-1786248 1.46845 0.031209 Uniprot/SPTREMBL:A0A0F7SF20 CDZ98595 Scaffold_262:816862-820045 1.46285 0.002826 Uniprot/SPTREMBL:A0A0F7SJH7 CDZ96765 Scaffold_79:275148-276949 1.46086 0.005005 Uniprot/SPTREMBL:A0A0F7SF58 CED82370 Scaffold_33:1159209-1160902 1.46051 0.003585 Uniprot/SPTREMBL:A0A0F7SPF9 CED84441 Scaffold_78:281458-282484 1.45883 0.039325 Uniprot/SPTREMBL:A0A0F7SSK4 CED84821 Scaffold_78:1400404-1402626 1.45723 0.001998 Uniprot/SPTREMBL:A0A0F7STL5 CED83992 Scaffold_69:1384528-1390584 1.45703 0.003585 Uniprot/SPTREMBL:A0A0F7SPB8 CED85625 Scaffold_249:2187157-2189464 1.45685 0.001074 Uniprot/SPTREMBL:A0A0F7SYG0 CED82584 Scaffold_33:1862368-1865218 1.45497 0.004297 Uniprot/SPTREMBL:A0A0F7SPF4 CDZ98305 Scaffold_242:592604-596344 1.45288 0.002826 Uniprot/SPTREMBL:A0A0F7SIU5 CDZ96872 Scaffold_79:584983-586708 1.45215 0.001074 Uniprot/SPTREMBL:A0A0F7SIT0 CED85203 Scaffold_249:864947-866126 1.44951 0.001074 Uniprot/SPTREMBL:A0A0F7SY49 CDZ96187 Scaffold_24:77879-79734 1.44778 0.005005 Uniprot/SPTREMBL:A0A0F7SGN5 CED82635 Scaffold_33:2007011-2008851 1.44289 0.039087 Uniprot/SPTREMBL:A0A0F7SQ56 CDZ97519 Scaffold_124:131824-135131 1.43614 0.008176 Uniprot/SPTREMBL:A0A0F7SJJ8 CDZ98632 Scaffold_262:919319-922346 1.43541 0.00697 Uniprot/SPTREMBL:A0A0F7SNG6 CED82723 Scaffold_52:185738-187226 1.43248 0.039087 Uniprot/SPTREMBL:A0A0F7SRM0 CED83667 Scaffold_69:419784-423977 1.4323 0.033335 Uniprot/SPTREMBL:A0A0F7SNP5 CED84931 Scaffold_249:9545-10343 1.43044 0.001998 Uniprot/SPTREMBL:A0A0F7STW7 CDZ97346 Scaffold_79:2017105-2018316 1.42427 0.001998 Uniprot/SPTREMBL:A0A0F7SF46 CED82879 Scaffold_52:682296-684509 1.42222 0.023063 Uniprot/SPTREMBL:A0A0F7SQF9 CED85363 Scaffold_249:1364200-1366036 1.41596 0.028707 Uniprot/SPTREMBL:A0A0F7SYN0 CED83093 Scaffold_52:1272752-1277459 1.40238 0.012168 Uniprot/SPTREMBL:A0A0F7SSQ8 CDZ97515 Scaffold_124:121733-122976 1.40111 0.008176 Uniprot/SPTREMBL:A0A0F7SGL2 CED85082 Scaffold_249:459159-460208 1.39994 0.001998 Uniprot/SPTREMBL:A0A0F7SS76 CED82416 Scaffold_33:1318149-1318509 1.39146 0.006352 Uniprot/SPTREMBL:A0A0F7SLW8 CDZ96555 Scaffold_54:529030-531464 1.39109 0.001998 Uniprot/SPTREMBL:A0A0F7SEX9 CED83550 Scaffold_69:64295-67968 1.38618 0.030842 Uniprot/SPTREMBL:A0A0F7SSM5 CED84396 Scaffold_78:126951-127725 1.38546 0.038728 Uniprot/SPTREMBL:A0A0F7SSE3 CED85377 Scaffold_249:1408739-1411342 1.38479 0.00946 Uniprot/SPTREMBL:A0A0F7ST75 CED83404 Scaffold_52:2200688-2204341 1.38262 0.006352 Uniprot/SPTREMBL:A0A0F7SRT1 CDZ96537 Scaffold_54:476312-485671 1.37497 0.002826 Uniprot/SPTREMBL:A0A0F7SHN7 CED84907 Scaffold_78:1683401-1684137 1.37476 0.030421 Uniprot/SPTREMBL:A0A0F7SRT5 CDZ98870 Scaffold_262:1660620-1662142 1.37382 0.003585 Uniprot/SPTREMBL:A0A0F7SKR5 CED83400 Scaffold_52:2189553-2193378 1.37211 0.038544 Uniprot/SPTREMBL:A0A0F7SS90 CED84717 Scaffold_78:1099608-1102777 1.36352 0.004297 Uniprot/SPTREMBL:A0A0F7SR63 CED83262 Scaffold_52:1748245-1750055 1.36085 0.033623 Uniprot/SPTREMBL:A0A0F7SMH1 CED85636 Scaffold_249:2230567-2237697 1.35621 0.008176 Uniprot/SPTREMBL:A0A0F7SVP1 CED83271 Scaffold_52:1774600-1776501 1.35608 0.00946 Uniprot/SPTREMBL:A0A0F7SP88 CED84610 Scaffold_78:800066-802271 1.35432 0.006352 Uniprot/SPTREMBL:A0A0F7SVM2 CDZ98422 Scaffold_262:270958-273739 1.35393 0.002826 Uniprot/SPTREMBL:A0A0F7SMV6 CDZ96871 Scaffold_79:578233-584688 1.34599 0.036323 Uniprot/SPTREMBL:A0A0F7SEK9 CDZ97741 Scaffold_162:423647-425533 1.34525 0.021426 Uniprot/SPTREMBL:A0A0F7SFV3 CDZ98291 Scaffold_242:539694-546572 1.33466 0.018414 Uniprot/SPTREMBL:A0A0F7SHB6 CDZ97728 Scaffold_162:389377-390258 1.33175 0.04182 Uniprot/SPTREMBL:A0A0F7SJA1 CDZ98348 Scaffold_262:54334-55821 1.33015 0.003585 Uniprot/SPTREMBL:A0A0F7SL12 CED84009 Scaffold_69:1435898-1436204 1.3291 0.019451 Uniprot/SPTREMBL:A0A0F7STM1 CED85638 Scaffold_249:2239413-2241638 1.32658 0.003585 Uniprot/SPTREMBL:A0A0F7SZ74 CED84849 Scaffold_78:1487844-1488916 1.32316 0.044221 Uniprot/SPTREMBL:A0A0F7SVU9 CDZ98506 Scaffold_262:521152-522007 1.32277 0.012761 Uniprot/SPTREMBL:A0A0F7SHR7 CED82117 Scaffold_33:352832-354601 1.31747 0.00697 Uniprot/SPTREMBL:A0A0F7SJ77 CED83712 Scaffold_69:556348-559225 1.31552 0.023063 Uniprot/SPTREMBL:A0A0F7SNS0 CDZ98726 Scaffold_262:1216707-1218957 1.3071 0.004297 Uniprot/SPTREMBL:A0A0F7SIG5 CED84966 Scaffold_249:102086-105924 1.30617 0.008794 Uniprot/SPTREMBL:A0A0F7SU20 CDZ98007 Scaffold_189:155162-158020 1.3058 0.02103 Uniprot/SPTREMBL:A0A0F7SM57 CED83352 Scaffold_52:2030450-2032970 1.30096 0.011005 Uniprot/SPTREMBL:A0A0F7SMR0 CED83142 Scaffold_52:1419683-1420879 1.29835 0.010025 Uniprot/SPTREMBL:A0A0F7SM39 CED82188 Scaffold_33:570189-571995 1.29177 0.008176 Uniprot/SPTREMBL:A0A0F7SPX6 CDZ96996 Scaffold_79:956121-957904 1.28872 0.011005 Uniprot/SPTREMBL:A0A0F7SER8 CDZ96775 Scaffold_79:305615-306953 1.28852 0.044221 Uniprot/SPTREMBL:A0A0F7SF61 CED82003 Scaffold_33:6263-8990 1.28482 0.008176 Uniprot/SPTREMBL:A0A0F7SPC8 CDZ98578 Scaffold_262:765711-771979 1.28359 0.038544 Uniprot/SPTREMBL:A0A0F7SLK6 CED85353 Scaffold_249:1337251-1339959 1.27446 0.025536 Uniprot/SPTREMBL:A0A0F7SYM4 CDZ98588 Scaffold_262:796167-798642 1.27123 0.013896 Uniprot/SPTREMBL:A0A0F7SLL0 CED83307 Scaffold_52:1875282-1876355 1.27038 0.022195 Uniprot/SPTREMBL:A0A0F7SMM7 CED84032 Scaffold_69:1512430-1513697 1.27023 0.021426 Uniprot/SPTREMBL:A0A0F7SPE1 CDZ98569 Scaffold_262:739379-741142 1.26802 0.041478 Uniprot/SPTREMBL:A0A0F7SM79 CDZ98688 Scaffold_262:1099242-1100302 1.26445 0.00697 Uniprot/SPTREMBL:A0A0F7SLR9 CED83715 Scaffold_69:562869-565995 1.24624 0.008794 Uniprot/SPTREMBL:A0A0F7ST29 CED83820 Scaffold_69:882993-885014 1.24418 0.024732 Uniprot/SPTREMBL:A0A0F7STE7 CED83549 Scaffold_69:61984-62980 1.24031 0.042833 Uniprot/SPTREMBL:A0A0F7SSE4 CED84460 Scaffold_78:355483-356767 1.23011 0.023063 Uniprot/SPTREMBL:A0A0F7SV97 CED85451 Scaffold_249:1624921-1626657 1.22324 0.043104 Uniprot/SPTREMBL:A0A0F7SV85 CED82386 Scaffold_33:1218622-1221995 1.22271 0.012761 Uniprot/SPTREMBL:A0A0F7SLV1 CED83043 Scaffold_52:1135868-1137875 1.22052 0.010525 Uniprot/SPTREMBL:A0A0F7SSK2 CDZ98811 Scaffold_262:1473304-1476092 1.21361 0.032587 Uniprot/SPTREMBL:A0A0F7SIN6 CDZ97506 Scaffold_124:85143-88051 1.20656 0.02507 Uniprot/SPTREMBL:A0A0F7SFD8 CED83086 Scaffold_52:1254770-1257364 1.19723 0.014998 Uniprot/SPTREMBL:A0A0F7SNS9 CED82788 Scaffold_52:403939-404632 1.19422 0.037386 Uniprot/SPTREMBL:A0A0F7SRW9 CED84216 Scaffold_69:2042437-2043750 1.19358 0.017391 Uniprot/SPTREMBL:A0A0F7SRY7 CDZ96433 Scaffold_54:153007-155386 1.1934 0.032587 Uniprot/SPTREMBL:A0A0F7SFP7 CDZ98349 Scaffold_262:56113-60622 1.19098 0.016475 Uniprot/SPTREMBL:A0A0F7SLT6 CED83191 Scaffold_52:1553706-1554253 1.18772 0.004297 Uniprot/SPTREMBL:A0A0F7SP16 CDZ98482 Scaffold_262:454249-456087 1.18613 0.028368 Uniprot/SPTREMBL:A0A0F7SN03 CDZ96583 Scaffold_54:624919-626843 1.18481 0.034352 Uniprot/SPTREMBL:A0A0F7SFW2 CDZ97486 Scaffold_124:25893-28134 1.18431 0.020508 Uniprot/SPTREMBL:A0A0F7SFC9 CED83905 Scaffold_69:1122672-1126938 1.17901 0.015553 Uniprot/SPTREMBL:A0A0F7STK9 CED83752 Scaffold_69:654878-656794 1.17072 0.031879 Uniprot/SPTREMBL:A0A0F7SNU1 CED83251 Scaffold_52:1716422-1717459 1.16668 0.038728 Uniprot/SPTREMBL:A0A0F7SP79 CED83476 Scaffold_52:2440519-2444040 1.16528 0.024732 Uniprot/SPTREMBL:A0A0F7SPZ9 CED83038 Scaffold_52:1127125-1128716 1.16222 0.031209 Uniprot/SPTREMBL:A0A0F7SSJ7 CDZ96921 Scaffold_79:720825-723066 1.15054 0.018414 Uniprot/SPTREMBL:A0A0F7SEP0 CED83405 Scaffold_52:2204641-2206845 1.15036 0.014466 Uniprot/SPTREMBL:A0A0F7SS92 CED85577 Scaffold_249:2034538-2035696 1.14395 0.022695 Uniprot/SPTREMBL:A0A0F7STS4 CED84341 Scaffold_69:2427694-2431829 1.14249 0.016101 Uniprot/SPTREMBL:A0A0F7SS93 CED84378 Scaffold_78:55256-58433 1.14156 0.025536 Uniprot/SPTREMBL:A0A0F7SWD5 CED83553 Scaffold_69:75264-77681 1.14032 0.024732 Uniprot/SPTREMBL:A0A0F7SU77 CED82771 Scaffold_52:350846-353099 1.13824 0.033623 Uniprot/SPTREMBL:A0A0F7SMY7 CDZ97021 Scaffold_79:1038990-1040784 1.13037 0.017391 Uniprot/SPTREMBL:A0A0F7SES3 CED83259 Scaffold_52:1738331-1743319 1.12885 0.038544 Uniprot/SPTREMBL:A0A0F7SR95 CED82412 Scaffold_33:1307391-1309267 1.12475 0.016475 Uniprot/SPTREMBL:A0A0F7SJZ3 CDZ98341 Scaffold_262:35667-38316 1.12283 0.028368 Uniprot/SPTREMBL:A0A0F7SHG1 CED85033 Scaffold_249:337165-337887 1.12149 0.019982 Uniprot/SPTREMBL:A0A0F7SXU0 CED82616 Scaffold_33:1954259-1956659 1.10658 0.039325 Uniprot/SPTREMBL:A0A0F7SMG4 CDZ97069 Scaffold_79:1183297-1184786 1.09255 0.029947 Uniprot/SPTREMBL:A0A0F7SIC3 CED85496 Scaffold_249:1787393-1789483 1.08855 0.020508 Uniprot/SPTREMBL:A0A0F7SVC5 CED83300 Scaffold_52:1857521-1859414 1.08604 0.031209 Uniprot/SPTREMBL:A0A0F7SS27 CDZ98200 Scaffold_242:250674-254711 1.08597 0.041478 Uniprot/SPTREMBL:A0A0F7SIG2 CED84746 Scaffold_78:1198346-1201827 1.0804 0.029947 Uniprot/SPTREMBL:A0A0F7STB9 CED83284 Scaffold_52:1809160-1812031 1.07834 0.04884 Uniprot/SPTREMBL:A0A0F7SRE1 CED84708 Scaffold_78:1072521-1075060 1.07826 0.031879 Uniprot/SPTREMBL:A0A0F7SX29 CED83817 Scaffold_69:875777-877630 1.07691 0.02507 Uniprot/SPTREMBL:A0A0F7SP17 CED83099 Scaffold_52:1293775-1295496 1.06576 0.021773 Uniprot/SPTREMBL:A0A0F7SQW6 CDZ98336 Scaffold_262:20250-23019 1.05966 0.037015 Uniprot/SPTREMBL:A0A0F7SHF8 CED82364 Scaffold_33:1144383-1147171 1.04101 0.03518 Uniprot/SPTREMBL:A0A0F7SNW1 CDZ98117 Scaffold_217:54-464 1.02549 0.038728 Uniprot/SPTREMBL:A0A0F7SMD0 CED83984 Scaffold_69:1359841-1362644 1.01909 0.029947 Uniprot/SPTREMBL:A0A0F7STJ7 CED84925 Scaffold_78:1735682-1737491 1.01862 0.038728 Uniprot/SPTREMBL:A0A0F7SWF4 CED82457 Scaffold_33:1446468-1449248 1.01542 0.04182 Uniprot/SPTREMBL:A0A0F7SK27 CDZ96188 Scaffold_24:80138-81245 1.00373 0.04884 Uniprot/SPTREMBL:A0A0F7SFB4 CED82454 Scaffold_33:1436004-1437727 0.992268 0.042098 Uniprot/SPTREMBL:A0A0F7SP07 CED83808 Scaffold_69:839010-841550 0.978993 0.047318 Uniprot/SPTREMBL:A0A0F7SV12 CED85102 Scaffold_249:534858-536034 0.985732 0.041196 Uniprot/SPTREMBL:A0A0F7SSD5 CDZ97737 Scaffold_162:414362-415273 1.0347 0.037015 Uniprot/SPTREMBL:A0A0F7SLC3 CED83020 Scaffold_52:1066811-1069140 1.03586 0.038238 Uniprot/SPTREMBL:A0A0F7SRA2 CDZ97353 Scaffold_79:2035798-2037908 1.04258 0.035564 Uniprot/SPTREMBL:A0A0F7SI09 CED83590 Scaffold_69:189208-191677 1.04734 0.044547 Uniprot/SPTREMBL:A0A0F7SSR7 CDZ97748 Scaffold_162:440988-444947 1.05847 0.046032 Uniprot/SPTREMBL:A0A0F7SJC1 CDZ98248 Scaffold_242:405320-407366 1.06134 0.034795 Uniprot/SPTREMBL:A0A0F7SKS7 CED82777 Scaffold_52:366477-369023 1.06214 0.024433 Uniprot/SPTREMBL:A0A0F7SKV2 CDZ98789 Scaffold_262:1417586-1420425 1.06443 0.02507 Uniprot/SPTREMBL:A0A0F7SMW9 CED85557 Scaffold_249:1982109-1984110 1.07089 0.042435 Uniprot/SPTREMBL:A0A0F7STQ4 CDZ98271 Scaffold_242:482272-482866 1.09092 0.045325 Uniprot/SPTREMBL:A0A0F7SHA1 CDZ98662 Scaffold_262:1019159-1020208 1.10081 0.023509 Uniprot/SPTREMBL:A0A0F7SNI7 CED82472 Scaffold_33:1494855-1496930 1.10171 0.018414 Uniprot/SPTREMBL:A0A0F7SK39 CDZ97707 Scaffold_162:338953-341097 1.10306 0.021773 Uniprot/SPTREMBL:A0A0F7SL99 CED85444 Scaffold_249:1598059-1599446 1.10671 0.024433 Uniprot/SPTREMBL:A0A0F7SXI2 CDZ96809 Scaffold_79:406623-408256 1.12039 0.024732 Uniprot/SPTREMBL:A0A0F7SHL1 CDZ96362 Scaffold_53:66709-68840 1.12412 0.041478 Uniprot/SPTREMBL:A0A0F7SH50 CDZ97886 Scaffold_162:851177-854338 1.12472 0.019451 Uniprot/SPTREMBL:A0A0F7SG92 CDZ97531 Scaffold_124:175643-176259 1.1447 0.011566 Uniprot/SPTREMBL:A0A0F7SFF4 CDZ97630 Scaffold_162:88839-89856 1.14847 0.014998 Uniprot/SPTREMBL:A0A0F7SGX6 CED85001 Scaffold_249:223979-224984 1.15874 0.02507 Uniprot/SPTREMBL:A0A0F7SU78 CED84248 Scaffold_69:2142836-2144757 1.1588 0.021426 Uniprot/SPTREMBL:A0A0F7SW39 CED84017 Scaffold_69:1466803-1468329 1.16715 0.023509 Uniprot/SPTREMBL:A0A0F7SPD2 CED84592 Scaffold_78:741601-743464 1.17198 0.017391 Uniprot/SPTREMBL:A0A0F7SQU2 CDZ96956 Scaffold_79:851688-852078 1.17483 0.032587 Uniprot/SPTREMBL:A0A0F7SEQ5 CED85092 Scaffold_249:492482-495573 1.17844 0.027321 Uniprot/SPTREMBL:A0A0F7SSC5 CED82255 Scaffold_33:790676-791081 1.18841 0.012761 Uniprot/SPTREMBL:A0A0F7SNS2 CED82283 Scaffold_33:873009-877325 1.19141 0.008176 Uniprot/SPTREMBL:A0A0F7SQ69 CED82196 Scaffold_33:596179-597979 1.19696 0.017391 Uniprot/SPTREMBL:A0A0F7SL59 CED83534 Scaffold_69:26238-28721 1.20197 0.014466 Uniprot/SPTREMBL:A0A0F7SSC9 CDZ97633 Scaffold_162:95746-97373 1.20226 0.016937 Uniprot/SPTREMBL:A0A0F7SIS9 CED83828 Scaffold_69:912691-913814 1.20493 0.010025 Uniprot/SPTREMBL:A0A0F7SV71 CED83695 Scaffold_69:506810-508045 1.20596 0.011566 Uniprot/SPTREMBL:A0A0F7ST13 CED85542 Scaffold_249:1928334-1933614 1.20846 0.010525 Uniprot/SPTREMBL:A0A0F7STP1 CED85129 Scaffold_249:609328-612469 1.23685 0.00946 Uniprot/SPTREMBL:A0A0F7SWG4 CDZ98405 Scaffold_262:223404-225048 1.24291 0.02962 Uniprot/SPTREMBL:A0A0F7SJ27 CED85490 Scaffold_249:1765942-1769233 1.25343 0.00697 Uniprot/SPTREMBL:A0A0F7SY73 CED85278 Scaffold_249:1098519-1099599 1.25754 0.011005 Uniprot/SPTREMBL:A0A0F7SYD5 CDZ98800 Scaffold_262:1444973-1446444 1.26381 0.010525 Uniprot/SPTREMBL:A0A0F7SKG7 CED84979 Scaffold_249:145173-147662 1.26975 0.014466 Uniprot/SPTREMBL:A0A0F7SW36 CED83389 Scaffold_52:2151630-2154286 1.27251 0.010525 Uniprot/SPTREMBL:A0A0F7SRR6 CDZ97840 Scaffold_162:727586-729218 1.27681 0.00697 Uniprot/SPTREMBL:A0A0F7SHH7 CED82710 Scaffold_52:148247-149050 1.27962 0.022195 Uniprot/SPTREMBL:A0A0F7SQ90 CDZ97744 Scaffold_162:432635-434201 1.288 0.021773 Uniprot/SPTREMBL:A0A0F7SK71 CED83517 Scaffold_52:2551434-2553636 1.30585 0.010025 Uniprot/SPTREMBL:A0A0F7SN81 CED83472 Scaffold_52:2424613-2428401 1.31501 0.002826 Uniprot/SPTREMBL:A0A0F7SN42 CDZ98888 Scaffold_262:1716621-1719877 1.31542 0.010525 Uniprot/SPTREMBL:A0A0F7SMT6 CED84417 Scaffold_78:190965-193843 1.31562 0.022695 Uniprot/SPTREMBL:A0A0F7SQC2 CED82856 Scaffold_52:615050-617722 1.34542 0.008176 Uniprot/SPTREMBL:A0A0F7SNB3 CDZ98000 Scaffold_189:132797-135164 1.35451 0.010025 Uniprot/SPTREMBL:A0A0F7SHY2 CED85117 Scaffold_249:574535-575250 1.36204 0.021426 Uniprot/SPTREMBL:A0A0F7SSF0 CED85637 Scaffold_249:2238001-2238611 1.36511 0.006352 Uniprot/SPTREMBL:A0A0F7STX9 CED83010 Scaffold_52:1037960-1038639 1.36959 0.005005 Uniprot/SPTREMBL:A0A0F7SR81 CED84090 Scaffold_69:1691100-1694027 1.3718 0.031879 Uniprot/SPTREMBL:A0A0F7SU51 CED84418 Scaffold_78:194247-197639 1.37256 0.016937 Uniprot/SPTREMBL:A0A0F7SWE3 CDZ97839 Scaffold_162:723435-726147 1.38193 0.019982 Uniprot/SPTREMBL:A0A0F7SKA0 CED85497 Scaffold_249:1790049-1792770 1.38461 0.022195 Uniprot/SPTREMBL:A0A0F7STK2 CED84228 Scaffold_69:2077031-2079020 1.38491 0.006352 Uniprot/SPTREMBL:A0A0F7SW30 CDZ98142 Scaffold_242:72315-72984 1.39076 0.016475 Uniprot/SPTREMBL:A0A0F7SMF1 CED83841 Scaffold_69:945530-947189 1.3942 0.003585 Uniprot/SPTREMBL:A0A0F7SR18 CED84830 Scaffold_78:1431276-1433662 1.41737 0.001074 Uniprot/SPTREMBL:A0A0F7SW68 CDZ96750 Scaffold_79:233801-235070 1.41946 0.005005 Uniprot/SPTREMBL:A0A0F7SF52 CDZ98868 Scaffold_262:1656053-1656973 1.42059 0.001074 Uniprot/SPTREMBL:A0A0F7SMR8 CDZ97870 Scaffold_162:808063-808921 1.42078 0.028707 Uniprot/SPTREMBL:A0A0F7SHK3 CED84081 Scaffold_69:1660757-1661605 1.42877 0.010525 Uniprot/SPTREMBL:A0A0F7SRM1 CED84218 Scaffold_69:2047542-2048755 1.43718 0.001074 Uniprot/SPTREMBL:A0A0F7SW26 CED84514 Scaffold_78:515920-517461 1.44083 0.005005 Uniprot/SPTREMBL:A0A0F7SUW1 CED84940 Scaffold_249:36361-39079 1.44153 0.006352 Uniprot/SPTREMBL:A0A0F7SWG3 CDZ96815 Scaffold_79:422815-425938 1.44247 0.001074 Uniprot/SPTREMBL:A0A0F7SF76 CED82015 Scaffold_33:46454-47993 1.44841 0.001074 Uniprot/SPTREMBL:A0A0F7SN44 CED84369 Scaffold_78:29525-30507 1.45503 0.003585 Uniprot/SPTREMBL:A0A0F7SUL5 CED83696 Scaffold_69:511061-511998 1.46363 0.011005 Uniprot/SPTREMBL:A0A0F7SQJ0 CED85556 Scaffold_249:1975453-1981704 1.47673 0.016475 Uniprot/SPTREMBL:A0A0F7SVI0 CED82505 Scaffold_33:1609241-1610829 1.48428 0.032989 Uniprot/SPTREMBL:A0A0F7SPT3 CED82697 Scaffold_52:107314-110474 1.4861 0.001074 Uniprot/SPTREMBL:A0A0F7SKM2 CDZ96174 Scaffold_24:45029-46448 1.48792 0.001998 Uniprot/SPTREMBL:A0A0F7SFZ4 CDZ97929 Scaffold_162:985527-987486 1.49375 0.001074 Uniprot/SPTREMBL:A0A0F7SKI7 CED83303 Scaffold_52:1864569-1867964 1.49629 0.001998 Uniprot/SPTREMBL:A0A0F7STG3 CDZ96727 Scaffold_79:168408-169040 1.50767 0.035564 Uniprot/SPTREMBL:A0A0F7SID4 CDZ98383 Scaffold_262:163269-165707 1.50983 0.001998 Uniprot/SPTREMBL:A0A0F7SL66 CDZ97208 Scaffold_79:1602896-1603746 1.52051 0.028024 Uniprot/SPTREMBL:A0A0F7SHL4 CED84696 Scaffold_78:1041262-1043489 1.52121 0.005005 Uniprot/SPTREMBL:A0A0F7ST73 CED85179 Scaffold_249:768057-769128 1.528 0.005005 Uniprot/SPTREMBL:A0A0F7SWN5 CDZ97456 Scaffold_79:2325450-2327139 1.53518 0.001998 Uniprot/SPTREMBL:A0A0F7SFB7 CED84729 Scaffold_78:1142277-1143722 1.54842 0.02507 Uniprot/SPTREMBL:A0A0F7SVE0 CDZ97944 Scaffold_162:1029594-1031564 1.55315 0.032288 Uniprot/SPTREMBL:A0A0F7SKJ3 CED82961 Scaffold_52:899381-901807 1.55439 0.001998 Uniprot/SPTREMBL:A0A0F7SNJ6 CED85145 Scaffold_249:663696-666391 1.56549 0.001074 Uniprot/SPTREMBL:A0A0F7SWW3 CDZ96993 Scaffold_79:946175-946791 1.56735 0.010025 Uniprot/SPTREMBL:A0A0F7SH00 CDZ98218 Scaffold_242:313958-314979 1.57462 0.039739 Uniprot/SPTREMBL:A0A0F7SKP7 CDZ97354 Scaffold_79:2038247-2039550 1.57466 0.026366 Uniprot/SPTREMBL:A0A0F7SJ53 CED85074 Scaffold_249:442737-444170 1.58124 0.001074 Uniprot/SPTREMBL:A0A0F7SWB7 CDZ97526 Scaffold_124:162119-164466 1.5836 0.001074 Uniprot/SPTREMBL:A0A0F7SFF1 CDZ98135 Scaffold_242:49823-52376 1.58729 0.001074 Uniprot/SPTREMBL:A0A0F7SI82 CED84431 Scaffold_78:237377-238586 1.60776 0.001074 Uniprot/SPTREMBL:A0A0F7SSJ4 CED85313 Scaffold_249:1208655-1213573 1.63218 0.004297 Uniprot/SPTREMBL:A0A0F7SYJ8 CED84836 Scaffold_78:1448687-1449940 1.63345 0.023995 Uniprot/SPTREMBL:A0A0F7STM7 CED83274 Scaffold_52:1784640-1786631 1.66122 0.022195 Uniprot/SPTREMBL:A0A0F7SRA0 CED85626 Scaffold_249:2189998-2193215 1.6636 0.001074 Uniprot/SPTREMBL:A0A0F7SVN2 CDZ97245 Scaffold_79:1727581-1730708 1.66565 0.015553 Uniprot/SPTREMBL:A0A0F7SFX9 CED85026 Scaffold_249:319340-320235 1.6759 0.001074 Uniprot/SPTREMBL:A0A0F7SU90 CDZ97907 Scaffold_162:926229-926777 1.68467 0.001074 Uniprot/SPTREMBL:A0A0F7SLM2 CED85146 Scaffold_249:667273-668861 1.6897 0.001074 Uniprot/SPTREMBL:A0A0F7SUH6 CDZ96446 Scaffold_54:193458-195288 1.69218 0.005005 Uniprot/SPTREMBL:A0A0F7SE96 CED85386 Scaffold_249:1428350-1429974 1.69704 0.007631 Uniprot/SPTREMBL:A0A0F7SV36 CED83236 Scaffold_52:1660428-1665437 1.70904 0.019451 Uniprot/SPTREMBL:A0A0F7SP66 CDZ97306 Scaffold_79:1907876-1908952 1.71442 0.001074 Uniprot/SPTREMBL:A0A0F7SF29 CED83823 Scaffold_69:895697-898455 1.71756 0.007631 Uniprot/SPTREMBL:A0A0F7SV28 CDZ97777 Scaffold_162:521349-522266 1.7263 0.001074 Uniprot/SPTREMBL:A0A0F7SLD7 CED85594 Scaffold_249:2084742-2086107 1.73902 0.001074 Uniprot/SPTREMBL:A0A0F7SXV3 CDZ97012 Scaffold_79:1010624-1012290 1.74477 0.017391 Uniprot/SPTREMBL:A0A0F7SJ45 CED85303 Scaffold_249:1175266-1177190 1.75298 0.030842 Uniprot/SPTREMBL:A0A0F7SYJ0 CDZ98236 Scaffold_242:365011-366553 1.76023 0.001074 Uniprot/SPTREMBL:A0A0F7SH75 CDZ96540 Scaffold_54:497380-497756 1.77148 0.001074 Uniprot/SPTREMBL:A0A0F7SEX6 CDZ96250 Scaffold_24:287314-287702 1.78589 0.025999 Uniprot/SPTREMBL:A0A0F7SEK1 CED82279 Scaffold_33:855341-858413 1.78693 0.001074 Uniprot/SPTREMBL:A0A0F7SNL5 CDZ96876 Scaffold_79:595587-596170 1.79528 0.005005 Uniprot/SPTREMBL:A0A0F7SEL1 CED83529 Scaffold_69:6140-10274 1.79593 0.013319 Uniprot/SPTREMBL:A0A0F7SSA8 CDZ98664 Scaffold_262:1024362-1027941 1.79806 0.043499 Uniprot/SPTREMBL:A0A0F7SMD3 CED83336 Scaffold_52:1970924-1973100 1.84478 0.001074 Uniprot/SPTREMBL:A0A0F7SPJ6 CDZ98496 Scaffold_262:495689-498598 1.86631 0.001998 Uniprot/SPTREMBL:A0A0F7SHQ9 CED83987 Scaffold_69:1368003-1369177 1.87504 0.001074 Uniprot/SPTREMBL:A0A0F7SPB6 CED82860 Scaffold_52:629851-631596 1.8768 0.001074 Uniprot/SPTREMBL:A0A0F7SQU0 CED84129 Scaffold_69:1804647-1807171 1.89497 0.001074 Uniprot/SPTREMBL:A0A0F7STY0 CDZ96983 Scaffold_79:922379-925116 1.90977 0.004297 Uniprot/SPTREMBL:A0A0F7SGZ2 CED83784 Scaffold_69:745510-748575 1.91551 0.001998 Uniprot/SPTREMBL:A0A0F7ST12 CED82708 Scaffold_52:141033-144586 1.92185 0.001074 Uniprot/SPTREMBL:A0A0F7SRK5 CED84035 Scaffold_69:1521641-1522601 1.947 0.026366 Uniprot/SPTREMBL:A0A0F7STX6 CED83223 Scaffold_52:1629817-1630351 1.95328 0.001074 Uniprot/SPTREMBL:A0A0F7ST26 CED85344 Scaffold_249:1300710-1302755 1.95401 0.001074 Uniprot/SPTREMBL:A0A0F7SXB7 CED83617 Scaffold_69:267842-271966 1.96243 0.001074 Uniprot/SPTREMBL:A0A0F7SNK8 CDZ96955 Scaffold_79:850815-851296 1.96811 0.011005 Uniprot/SPTREMBL:A0A0F7SFD0 CDZ96589 Scaffold_54:643479-645853 1.98651 0.001074 Uniprot/SPTREMBL:A0A0F7SGX4 CDZ97148 Scaffold_79:1418833-1420884 1.98756 0.012168 Uniprot/SPTREMBL:A0A0F7SHA7 CED83678 Scaffold_69:454981-456676 2.00538 0.013896 Uniprot/SPTREMBL:A0A0F7SUM1 CDZ97063 Scaffold_79:1160642-1161469 2.00563 0.001074 Uniprot/SPTREMBL:A0A0F7SH47 CED83232 Scaffold_52:1650347-1652499 2.00736 0.019451 Uniprot/SPTREMBL:A0A0F7SME3 CED84569 Scaffold_78:683193-684172 2.01311 0.038728 Uniprot/SPTREMBL:A0A0F7SUZ6 CED85593 Scaffold_249:2082233-2084415 2.0274 0.001074 Uniprot/SPTREMBL:A0A0F7SZ46 CED82571 Scaffold_33:1819188-1821941 2.03204 0.001074 Uniprot/SPTREMBL:A0A0F7SMA6 CED82024 Scaffold_33:79365-79988 2.03815 0.001074 Uniprot/SPTREMBL:A0A0F7SMX9 CED84840 Scaffold_78:1463247-1464601 2.04553 0.001074 Uniprot/SPTREMBL:O60019 CDZ97958 Scaffold_185:2335-3721 2.05558 0.001074 Uniprot/SPTREMBL:A0A0F7SJV4 CDZ96695 Scaffold_79:79818-82579 2.05792 0.001074 Uniprot/SPTREMBL:A0A0F7SF31 CED84039 Scaffold_69:1530094-1533993 2.06613 0.001074 Uniprot/SPTREMBL:A0A0F7STP4 CED83377 Scaffold_52:2117808-2120026 2.08523 0.001074 Uniprot/SPTREMBL:A0A0F7SMT0 CED82529 Scaffold_33:1688676-1690831 2.1036 0.010525 Uniprot/SPTREMBL:A0A0F7SP73 CDZ97994 Scaffold_189:112542-113046 2.11032 0.001074 Uniprot/SPTREMBL:A0A0F7SKM4 CED83890 Scaffold_69:1080480-1082192 2.12819 0.001074 Uniprot/SPTREMBL:A0A0F7STJ5 CED82578 Scaffold_33:1844646-1846846 2.14622 0.001074 Uniprot/SPTREMBL:A0A0F7SR99 CDZ98694 Scaffold_262:1113499-1115533 2.17485 0.001074 Uniprot/SPTREMBL:A0A0F7SMM3 CED84398 Scaffold_78:130805-133471 2.17595 0.001074 Uniprot/SPTREMBL:A0A0F7SWD9 CED85532 Scaffold_249:1894027-1894929 2.22038 0.001074 Uniprot/SPTREMBL:A0A0F7STN3 CDZ96641 Scaffold_77:26787-28432 2.23969 0.001074 Uniprot/SPTREMBL:A0A0F7SED5 CED85075 Scaffold_249:444854-448105 2.24815 0.001074 Uniprot/SPTREMBL:A0A0F7SWN2 CDZ96176 Scaffold_24:47894-49932 2.26781 0.037813 Uniprot/SPTREMBL:A0A0F7SE42 CDZ96699 Scaffold_79:90772-94522 2.27624 0.001074 Uniprot/SPTREMBL:A0A0F7SHB2 CED82661 Scaffold_33:2081366-2082099 2.29285 0.042098 Uniprot/SPTREMBL:A0A0F7SMJ8 CED85015 Scaffold_249:277754-280328 2.2993 0.001074 Uniprot/SPTREMBL:A0A0F7SWK9 CDZ97249 Scaffold_79:1746839-1748488 2.3182 0.001074 Uniprot/SPTREMBL:A0A0F7SIX6 CDZ96334 Scaffold_47:23-661 2.32877 0.001074 Uniprot/SPTREMBL:A0A0F7SGD2 CED83532 Scaffold_69:20326-23031 2.35024 0.001074 Uniprot/SPTREMBL:A0A0F7SN95 CED84492 Scaffold_78:450665-451017 2.36775 0.001074 Uniprot/SPTREMBL:A0A0F7SQK1 CED85166 Scaffold_249:719426-720769 2.37977 0.001074 Uniprot/SPTREMBL:A0A0F7SUI9 CED83489 Scaffold_52:2474332-2475671 2.38064 0.001074 Uniprot/SPTREMBL:A0A0F7SS48 CDZ96278 Scaffold_24:368207-369197 2.39138 0.002826 Uniprot/SPTREMBL:A0A0F7SFI5 CED84034 Scaffold_69:1519055-1520738 2.4005 0.001074 Uniprot/SPTREMBL:A0A0F7STP0 CED84697 Scaffold_78:1044388-1045081 2.40872 0.001998 Uniprot/SPTREMBL:A0A0F7SR45 CDZ97983 Scaffold_189:81800-82783 2.41732 0.001074 Uniprot/SPTREMBL:A0A0F7SJX3 CDZ96933 Scaffold_79:768574-769075 2.44241 0.001074 Uniprot/SPTREMBL:A0A0F7SGQ8 CDZ98807 Scaffold_262:1460878-1462217 2.46814 0.001998 Uniprot/SPTREMBL:A0A0F7SP56 CED84065 Scaffold_69:1612575-1613807 2.48264 0.001074 Uniprot/SPTREMBL:A0A0F7SU21 CDZ98091 Scaffold_189:408922-411088 2.49712 0.001074 Uniprot/SPTREMBL:A0A0F7SGR3 CED85462 Scaffold_249:1676632-1679003 2.50553 0.001074 Uniprot/SPTREMBL:A0A0F7STH0 CDZ97924 Scaffold_162:971572-972091 2.53677 0.001074 Uniprot/SPTREMBL:A0A0F7SKI4 CDZ97392 Scaffold_79:2152424-2153342 2.55979 0.001074 Uniprot/SPTREMBL:A0A0F7SKD9 CED84952 Scaffold_249:70148-71328 2.57142 0.001074 Uniprot/SPTREMBL:A0A0F7SRU8 CED83368 Scaffold_52:2087748-2092282 2.61347 0.001074 Uniprot/SPTREMBL:A0A0F7STR3 CED83646 Scaffold_69:350868-353990 2.66544 0.001074 Uniprot/SPTREMBL:A0A0F7SQG8 CED85401 Scaffold_249:1467760-1469049 2.69341 0.001074 Uniprot/SPTREMBL:A0A0F7SV47 CED82304 Scaffold_33:956694-958264 2.71132 0.001074 Uniprot/SPTREMBL:A0A0F7SNT3 CDZ97780 Scaffold_162:527493-528752 2.73943 0.001074 Uniprot/SPTREMBL:A0A0F7SHC9 CED82230 Scaffold_33:706033-706327 2.74682 0.001074 Uniprot/SPTREMBL:A0A0F7SNQ6 CED84839 Scaffold_78:1459933-1461957 2.76513 0.001074 Uniprot/SPTREMBL:A0A0F7SVU5 CDZ97703 Scaffold_162:322608-324574 2.77756 0.002826 Uniprot/SPTREMBL:A0A0F7SJ79 CED84019 Scaffold_69:1470201-1473044 2.78186 0.001074 Uniprot/SPTREMBL:A0A0F7STM8 CED85116 Scaffold_249:571977-573388 2.84413 0.001074 Uniprot/SPTREMBL:A0A0F7SUE0 CDZ98221 Scaffold_242:318841-320089 2.86547 0.001074 Uniprot/SPTREMBL:A0A0F7SH67 CDZ96418 Scaffold_54:107801-108657 2.90528 0.001074 Uniprot/SPTREMBL:A0A0F7SFN9 CED82158 Scaffold_33:482712-485332 2.96302 0.001074 Uniprot/SPTREMBL:A0A0F7SPV3 CED83626 Scaffold_69:289862-292855 3.0158 0.001074 Uniprot/SPTREMBL:A0A0F7SQF3 CED82286 Scaffold_33:885651-888286 3.13743 0.001074 Uniprot/SPTREMBL:A0A0F7SLG8 CED82646 Scaffold_33:2036969-2038849 3.14718 0.001074 Uniprot/SPTREMBL:A0A0F7SMJ2 CED82645 Scaffold_33:2031954-2035008 3.22499 0.001074 Uniprot/SPTREMBL:A0A0F7SQ63 CED82966 Scaffold_52:916495-918046 3.27009 0.001074 Uniprot/SPTREMBL:A0A0F7SNJ9 CDZ98220 Scaffold_242:316107-317206 3.33816 0.001074 Uniprot/SPTREMBL:A0A0F7SII2 CDZ97624 Scaffold_162:66225-66878 3.36931 0.001074 Uniprot/SPTREMBL:A0A0F7SJS3 CED83962 Scaffold_69:1288283-1292950 3.46187 0.003585 Uniprot/SPTREMBL:A0A0F7SPA4 CDZ96670 Scaffold_77:106964-110092 3.50921 0.001074 Uniprot/SPTREMBL:A0A0F7SF12 CDZ96436 Scaffold_54:160437-161831 3.66011 0.001074 Uniprot/SPTREMBL:A0A0F7SE94 CED85434 Scaffold_249:1567428-1569423 3.74639 0.001074 Uniprot/SPTREMBL:A0A0F7SXH6 CDZ96388 Scaffold_54:18689-18947 3.88549 0.001074 Uniprot/SPTREMBL:A0A0F7SFM4 CDZ96819 Scaffold_79:433020-434119 4.1179 0.001074 Uniprot/SPTREMBL:A0A0F7SHM0 CDZ96258 Scaffold_24:318573-319834 4.2954 0.001074 Uniprot/SPTREMBL:A0A0F7SFH3 CED83073 Scaffold_52:1224482-1226236 4.39164 0.001074 Uniprot/SPTREMBL:A0A0F7SSN1 CDZ97363 Scaffold_79:2059802-2060236 4.42159 0.014998 Uniprot/SPTREMBL:A0A0F7SI17 CDZ96973 Scaffold_79:896164-897185 4.44277 0.001074 Uniprot/SPTREMBL:A0A0F7SGV4 CED84060 Scaffold_69:1592326-1594451 4.5001 0.001074 Uniprot/SPTREMBL:A0A0F7SU17 CDZ98154 Scaffold_242:109579-111004 4.58439 0.001074 Uniprot/SPTREMBL:A0A0F7SL35 CED82980 Scaffold_52:954553-957016 4.59855 0.001074 Uniprot/SPTREMBL:A0A0F7SR47 CED85062 Scaffold_249:401979-403145 4.85533 0.001074 Uniprot/SPTREMBL:A0A0F7SS57
TABLE-US-00017 TABLE 17 Enzyme name Gene ID Log.sub.2 change q-value Significant T.sub.1 Glucose-6-phosphate 1-dehydrogenase CED83429 0.42 0.6681 no T.sub.2 Phosphoglucomutase/phosphomannomutase CDZ97253 0.74 0.2877 no T.sub.3 6-phosphofructokinase CDZ97071 1.04 0.2238 no T.sub.4 Glucose-6-phosphate isomerase CED83630 1.43 0.1038 no T.sub.5 Fructose 1,6-bisphosphate aldolase CDZ98367 0 0.9982 no T.sub.6 Phosphoglycerate mutase CED83840 0.79 0.1508 no T.sub.7 Phosphoglycerate kinase CDZ96270 0.96 0.3434 no T.sub.8 Glyceraldehyde-3-phosphate dehydrogenase CED85376 0.5 0.8098 no T.sub.9 Enolase CED83362 0.51 0.7568 no T.sub.10 Pyruvate kinase CDZ98564 0.87 0.398 no T.sub.11 Pyruvate decarboxylase CED83333 1.68 0.0746 no T.sub.12 Isocitrate lyase CED85129 1.24 0.0095 yes T.sub.13 Citrate synthase CED84246 0.71 0.2059 no T.sub.14 Aconitate hydratase CED85427 0.18 0.8799 no T.sub.15 Ketoglutarate dehydrogenase CED83799 1.55 0.0156 yes T.sub.16 Succinate dehydroganase CDZ98193 2.8 0.0011 yes T.sub.17 Malate synthase CED85130 0.14 0.8949 no T.sub.18 6-phosphogluconate decarboxylating CED82777 1.06 0.0244 yes T.sub.19 Gluconate kinase CDZ97633 1.2 0.0169 yes T.sub.20 Geranylgeranyl pyrophosphate synthase CED82684 0.86 0.4365 no T.sub.21 Phytoene dehydrogenase CED83513 1.8 0.2754 no T.sub.22 Phytoene-beta carotene synthase CED83449 1.52 0.087 no T.sub.23 Astaxanthin synthase CED83940 2.23 0.0057 yes T.sub.24 Cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies CED84998 4.05 0.0011 yes T.sub.25 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies CDZ98632 1.44 0.007 yes T.sub.26 Cytochrome P450 CYP2 subfamily CED85015 2.3 0.0011 yes T.sub.27 Apocytochrome b CED80059 5.32 0.0011 yes T.sub.28 Cytochrome b CED80058 5.15 0.0011 yes T.sub.29 NADH: ubiquinone/plastoquinone oxidoreductase, chain 3 CDZ96154 4.73 0.0043 yes T.sub.30 NADH: ubiquinone oxidoreductase, NDUFA9/39 kDa subunit CED84925 1.02 0.0387 yes T.sub.31 Cytochrome c oxidase subunit 1 CED80056 5.57 0.0011 yes T.sub.32 Cytochrome c oxidase subunit 2 CDZ96152 5.3 0.0011 yes T.sub.33 Cytochrome c oxidase subunit 3 CED80061 5.01 0.0011 yes T.sub.34 Cytochrome c oxidase assembly protein PET191 CED84572 1.67 0.0393 yes T.sub.35 Putative cytochrome c oxidase, subunit COX19 CED82283 1.19 0.0082 yes T.sub.36 ATP synthase subunit 6 CDZ96150 5.25 0.0011 yes T.sub.37 ATP synthase subunit mitochondrial CDZ96333 4.65 0.0011 yes T.sub.38 NADH dehydrogenase subunits 2, 5, and related proteins CDZ96153 6.01 0.0011 yes T.sub.39 NADH dehydrogenase subunit 4 CDZ96151 4.13 0.0011 yes T.sub.40 Aldo/keto reductase family proteins CDZ97194 1.85 0.0043 yes T.sub.41 Aldo/keto reductase family proteins CDZ97021 1.13 0.0174 yes T.sub.42 Hexose carrier protein CED82529 2.1 0.0105 yes T.sub.43 Hexokinase CED82858 1.3 0.1658 no T.sub.44 Ferredoxin/adrenodoxin reductase CDZ98521 1.87 0.0438 yes T.sub.45 acyl-dehydrogenase CED84717 1.36 0.0042 yes T.sub.46 hexose carrier protein CED82529 2.1 0.0105 yes T.sub.47 Catalase 1 CDZ96425 3.16 0.0057 yes T.sub.48 Catalase-like domain CDZ98863 1.53 0.0149 yes T.sub.49 Glutathione S-transferase CED84930 6.68 0.001 yes T.sub.50 Glutathione S-transferase CDZ97957 5.4 0.001 yes T.sub.51 Predicted glutathione S-transferase CED82196 1.19 0.0173 yes T.sub.52 Delta 9 fatty acid desaturase CED83656 0.53 0.7699 no T.sub.53 Asparagine synthase CED83843 2.35 0.0081 yes T.sub.54 Copper transporter CED82663 2.36 0.001 yes T.sub.55 Conidiation-specific protein 6 CDZ97534 3.17 0.001 yes
TABLE-US-00018 TABLE 18 Protein log2FC adj. pvalue Protein name CDZ96711 3.272326443 0.00057316 short-chain dehydrogenase CED82658 2.557045495 0.01154058 Deoxyribodipyrimidine photolyase/cryptochrome CED84367 2.318616444 0.01799604 Nuclear transport factor 2 CED85066 2.239020548 0.03538521 60s ribosomal protein I32 CED82723 2.140206091 0.01820556 Armadillo/beta-catenin-like repeat-containing protein CDZ96346 2.1328695 0.02431585 60s ribosomal protein I10a CED83196 2.114885867 0.00057316 Pyridoxamine 5-phosphate oxidase-like, FMN-binding domain CDZ97688 1.962719758 0.0472272 glutaredoxin-related protein CED82344 1.930631149 0.01505998 Glycosyl transferase, family 8-glycogenin CDZ96731 1.92915995 0.0156358 mitochondrial carrier CED85501 1.799809195 0.02428145 nucleosome assembly protein CED85055 1.731193901 0.03932151 Sterile alpha motif, type 2 CED84052 1.690858303 0.00057316 snare protein ykt6 CED82753 1.672583239 0.0472272 udp-glucose dehydrogenase CED82004 1.648999686 0.0188681 Predicted translation factor, contains W2 domain CED82942 1.626342108 0.0195415 G protein beta subunit-like protein CED82433 1.618966359 0.01109532 heat shock protein hss1 CED84880 1.610275821 0.03376189 40s ribosomal protein s7 CED83740 1.589899371 0.00905229 atp synthase f1 beta subunit CED82360 1.561433152 0.01276031 hypothetical protein CDZ96425 1.552015184 0.01060517 catalase 1 CED84965 1.534893848 0.04391875 Stress responsive alpha-beta barrel CED83216 1.48274394 0.01649435 Uncharacterized conserved protein CED85079 1.452711928 0.03416979 Cytokinin riboside 5-monophosphate phosphoribohydrolase LOG CDZ96256 1.400081003 0.01652963 EF-hand domain pair CED84618 1.363223801 0.01583624 20s proteasome subunit CDZ96583 1.336737341 0.0020292 ferrochelatase CDZ98540 1.304088911 0.03416979 glycine hydroxymethyltransferase CDZ98291 1.299250675 0.03376189 carboxypeptidase s CED84995 1.27866734 0.0020292 nadh-ubiquinone oxidoreductase 304 kda subunit precursor CED83513 1.272006068 0.00427065 phytoene dehydrogenase CED82558 1.255848347 0.03519539 Ribosomal protein L49/IMG2 CED85248 1.21214568 0.03416979 nop10p-domain-containing protein CED84223 1.211570639 0.03297342 Thioredoxin/protein disulfide isomerase CDZ96398 1.210395736 0.01697913 Predicted dehydrogenase CED82081 1.124637661 0.03043844 6-phosphogluconate dehydrogenase CDZ97938 1.090327535 0.01799604 NADH-dehydrogenase (ubiquinone) CDZ97188 1.041653101 0.02454864 COPII vesicle protein CED82583 0.972812085 0.04622283 ornithine aminotransferase CDZ97607 0.961343748 0.02264306 er-associated protein catabolism-related protein CDZ98576 0.956641899 0.04101412 isocitrate dehydrogenase CED83153 0.937690879 0.00164427 aaa atpase CED83708 0.919968342 0.02513695 probable nadp( )-dependent dehydrogenase acting on 3-hydroxy acids CED82933 0.915744964 0.00468473 cndp dipeptidase CED83441 0.899886386 0.01389815 Actin-related protein Arp2/3 complex, subunit ARPC2 CED84012 0.882703364 0.0396396 branched-chain amino acid aminotransferase ii CED85564 0.878847461 0.03403724 Carbon-nitrogen hydrolase CED84537 0.86940849 0.04899403 aspartate aminotransferase CED84732 0.819059765 0.01820556 NADPH oxidase CDZ96582 0.783460677 0.00757621 26s proteasome subunit p45 CED84295 0.727101959 0.04595691 pre-mrna-splicing factor rse1 CDZ97585 0.702232279 0.04441472 Porphobilinogen deaminase CDZ97299 0.684300182 0.02856417 prolyl oligopeptidase CED83351 0.53279685 0.01820556 abc transporter CED83447 0.540843796 0.04054781 40s ribosomal protein s9 CED82282 0.549026515 0.02203629 polyadenylate-binding protein CED83463 0.549306874 0.02914553 atp-dependent rna helicase dhx8 CDZ96620 0.550699218 0.00730273 Fatty acid synthase complex subunit alpha CED85357 0.552976694 0.03416979 glycosyltransferase family 35 protein CDZ98458 0.579289258 0.0396396 hypothetical protein CDZ97730 0.588026153 0.03442525 WD repeat protein CED83001 0.592611944 0.0185739 heat shock protein 60 ame: full = 60 kda chaperonin CED83868 0.625916454 0.03416979 succinate dehydrogenase CDZ97731 0.643476843 0.01109532 Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72 CDZ97556 0.643931077 0.02878294 hypothetical protein CDZ96847 0.645141048 0.01932677 nucleic acid-binding protein CDZ98246 0.651973989 0.03188712 Nucleotide excision repair factor NEF2, RAD23 component CED84183 0.685890266 0.0188681 carbon-nitrogen hydrolase CDZ97282 0.69152768 0.02513695 t-complex protein alpha subunit (tcp-1-alpha) CED82059 0.693303008 0.04460738 fk506-binding protein 2 CED85216 0.695853389 0.04250729 Aromatic amino acid aminotransferase and related proteins CDZ97115 0.702133604 0.00468473 adenylate kinase CDZ96380 0.730249947 0.0188681 alpha-aminoadipate reductase lys1p CED82220 0.730863676 0.02513695 coatomer protein subunit alpha CED82774 0.745400143 0.04391875 40s ribosomal protein s21 CED83139 0.74609568 0.00828925 carbamoyl-phosphate synth CDZ98369 0.746457631 0.00730273 Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily CED82652 0.758190818 0.04990868 SAM-dependent RNA methyltransferase, predicted CED83286 0.775731741 0.01093808 related to 2-hydroxy-3-oxopropionate reductase CED84878 0.779531222 0.03376189 Transcriptional coactivator p100 CDZ97020 0.781450259 0.02649992 60s ribosomal protein I13a CDZ96477 0.785705988 0.01799604 ornithine carbamoyltransferase CDZ98039 0.788300037 0.01799604 eukaryotic translation initiation factor 5b CED85427 0.80342206 0.03519539 aconitate hydratase CED82232 0.807033917 0.02649992 rrna 2-o-methyltransferase fibrillarin CED84791 0.820220844 0.03029551 t-complex protein beta subunit (tcp-1-beta) CED84188 0.835143316 0.02856417 voltage-dependent ion-selective channel CDZ98718 0.835331242 0.0118088 coatomer beta subunit CED84980 0.840382794 0.00778145 succinate-ligase (adp-forming) CED83765 0.85429126 0.02649992 carbamoyl-phosphate synthase CDZ96447 0.854577872 0.03155268 related to ste23-metalloprotease involved in a- factor processing CED83665 0.85634675 0.02060729 microtubule binding protein CED82100 0.857908244 0.0396396 Pyridoxalphosphate-dependent enzyme/predicted threonine synthase CED83464 0.868102971 0.04122494 fact complex subunit spt16 CDZ96576 0.876356779 0.01688491 sly1 vesicle trafficking sec1-like protein CDZ97524 0.883112569 0.01168687 cytoplasm protein CED84444 0.893719592 0.00229207 nadh dehydrogenase CED85449 0.903173171 0.04250729 20s proteasome subunit CDZ96270 0.918929334 0.0020292 phosphoglycerate kinase CED84681 0.929912636 0.03631055 arm repeat-containing protein CDZ97551 0.932426135 0.03282912 Ribonuclease III domain CED84960 0.938006938 0.02264306 gtp binding protein 4 CED82053 0.949623751 0.03376189 peptidyl-prolyl cis-trans isomerase b CDZ96524 0.9544128 0.01168687 Translation initiation factor 4F, ribosome/mRNA- bridging subunit (elF-4G) CED83897 0.974995763 0.02513695 nucleosome assembly protein CDZ96352 0.983332602 0.00831414 eukaryotic polypeptide chain release factor 3 CDZ98525 0.992343475 0.02215675 asparagine synthase (glutamine-hydrolyzing) CED84522 0.993837467 0.04128817 Splicing factor U2AF, large subunit (RRM superfamily) CED82181 1.005480158 0.00925982 nadh-cytochrome b5 reductase CED82591 1.029639978 0.03787191 histidine biosynthesis trifunctional-protein CED83723 1.037585374 0.04122494 Enoyl-CoA hydratase CDZ97012 1.043031541 0.01932677 alcohol CDZ96916 1.043355493 0.01932677 imidazoleglycerol phosphate synthase CED84114 1.043474748 0.03331544 Thioredoxin-like fold CDZ98026 1.044917324 0.02651527 ef-hand CED83652 1.05240471 0.00905229 electron-transferring-flavoprotein dehydrogenase CED82273 1.056067612 0.02914553 mbf1-domain-containing protein CED82044 1.067075615 0.02878294 Transcription factor IIS, N-terminal CED83685 1.067321455 0.00361302 heat shock protein 70 CED82614 1.073787138 0.0020292 pyruvate carboxylase CDZ96680 1.074598877 0.01276031 homoaconitate hydratase CED83939 1.078083583 0.03043844 Uncharacterized conserved coiled-coil protein CED83611 1.095807523 0.0238592 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) CDZ98729 1.100728689 0.02432014 eukaryotic translation initiation factor 3 subunit 7 CED83034 1.100823166 0.00057316 threonyl-trna synthetase CDZ98402 1.103940436 0.02748415 RmIC-like jelly roll fold CED85540 1.128024094 0.00468473 60s ribosomal protein I20 CED83021 1.148413349 0.04783144 mRNA splicing factor CDZ97267 1.149128196 0.00905229 pre-mrna-processing protein 45 CED82480 1.149348994 0.04702612 atp-dependent rrna helicase rrp3 CDZ96746 1.154878981 0.02549825 dihydrolipoyllysine-residue acetyltransferase CED83926 1.172857388 0.04339517 Acyl-CoA synthetase CDZ98315 1.177258586 0.02432014 Ribosomal protein S5 CDZ98765 1.177803882 0.01508991 phenylalanyl-trna synthetase subunit beta CED82811 1.179117557 0.00926928 wd40 repeat-like protein CDZ98852 1.183130469 0.01583624 vacuolar atp synthase subunit d CED83932 1.187051314 0.03441326 Phosphatidylserine decarboxylase CDZ98263 1.196465477 0.02645449 Vigilin CED84276 1.205793039 0.02212097 RNA recognition motif domain CED82490 1.21564933 0.01253292 plasma membrane h( )-atpase 1 CED83200 1.217961416 0.03376189 RRM motif-containing protein CDZ97483 1.218256982 0.01389815 Predicted GTPase-activating protein CED83084 1.225292534 0.0472272 F1-ATP synthase assembly protein CDZ97245 1.233180145 0.00905229 acetyl-hydrolase CDZ96943 1.240309934 0.01350904 Peptidyl-prolyl cis-trans isomerase CDZ97689 1.249838431 0.02649992 antiviral helicase CDZ98179 1.259964099 0.00361302 Acetyl CoA carboxylase CED84347 1.263008364 0.01393287 agc pka protein kinase CED83589 1.265861918 0.01218618 ATP-dependent RNA helicase pitchoune CED83658 1.266003386 0.04316808 Microtubule-associated protein CED82186 1.268044412 0.0308089 Cell-cycle nuclear protein, contains WD-40 repeats CED84113 1.27089372 0.03126627 phosphoserine aminotransferase CED84268 1.280229433 0.02549825 Vacuolar protein sorting-associated protein CED84243 1.280431294 0.0018404 gmp synthase CDZ96172 1.287548114 0.02941486 translational regulator gcn20-like abc transporter CED82356 1.288291751 0.04391875 GDP-mannose pyrophosphorylase CED84922 1.289443888 0.00874094 Acetyl CoA acyltransferase 2 CED84556 1.292812239 0.01932677 phosphoketolase CED84796 1.295776509 0.03376189 Delta 12 fatty acid desaturase CED83864 1.313283154 0.02649992 vacuolar protein 8 CED82178 1.320876871 0.0118088 Predicted haloacid-halidohydrolase and related hydrolases CDZ97101 1.32734763 0.02988308 peptidyl-prolyl cis-trans isomerase CDZ98445 1.335643909 0.03297342 class iii adh enzyme CDZ98528 1.335685233 0.00905229 carbamoyl-phosphate synthase CED83469 1.348907932 0.00905229 t-complex protein 1 CED85129 1.349857903 0.03671048 isocitrate lyase CED83250 1.359585261 0.02549825 atpase CED83852 1.380864038 0.04702612 6-phosphogluconolactonase CDZ97571 1.389240555 0.04290904 mitochondrial inner membrane protein CED84645 1.395950599 0.02960533 t-complex protein 1 subunit delta CED84885 1.400831215 0.0310697 adaptor protein complex ap-1 gamma subunit CED84004 1.410145406 0.03448029 arm repeat-containing protein CDZ96721 1.413395703 0.02914553 rRNA processing protein Rrp5 CDZ97030 1.424528912 0.00099383 succinate:fumarate antiporter CED85589 1.425848646 0.02839911 Predicted proline-serine-threonine phosphatase- interacting protein (PSTPIP) CED82624 1.43305487 0.02513695 phospho-2-dehydro-3-deoxyheptonate aldolase CED84664 1.433337418 0.00831414 rna-binding domain-containing protein CED83236 1.435153651 0.00374945 epsilon dna polymerase CDZ96438 1.436256297 0.0182665 Cullins CED82493 1.438548522 0.03416979 asparaginyl-trna synthetase CED83361 1.441977148 0.00926928 dihydroxy-acid dehydratase CDZ97327 1.448812399 0.00828925 hypothetical protein CDZ96706 1.450203913 0.01001901 SNARE protein SED5/Syntaxin 5 CDZ96703 1.468072782 0.02645449 centromere microtubule binding protein cbf5 CDZ97922 1.483216564 0.01093808 histidyl-trna synthetase CDZ96493 1.521855592 0.01791703 Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif CED84450 1.533220692 0.01109532 3-isopropylmalate dehydrogenase CED84039 1.537415237 0.04054781 Glycosyl transferase, family 1 CDZ97426 1.540107744 0.00468097 eukaryotic translation initiation factor 3 subunit 6 CED83785 1.543039464 0.04316808 phosphoglycerate mutase family CED84622 1.543931468 0.02549825 chromatin remodelling complex atpase chain CED85268 1.553723075 0.04128817 carboxypeptidase s CED84941 1.560007044 0.01060517 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) CDZ96153 1.561131772 0.04339517 NADH dehydrogenase subunits 2, 5, and related proteins CDZ97901 1.567756257 0.03376189 synaptobrevin-like protein CED85483 1.575183227 0.00905229 40s ribosomal protein s6 CDZ98650 1.581282177 0.02428145 Ubiquitin C-terminal hydrolase UCHL1 CED82653 1.587084692 0.02889048 PolyC-binding proteins alphaCP-1 and related KH domain proteins CED82987 1.587476435 0.02432014 Nucleolar RNA-associated protein (NRAP) CED82302 1.589117444 0.03376189 WD40 repeat-containing protein CED83333 1.590249823 0.0020292 pyruvate decarboxylase CED84972 1.5960981 0.01093808 NADH-dehydrogenase (ubiquinone) CDZ97229 1.596189229 0.04783144 RhoGEF GTPase CED82008 1.598536492 0.01016089 Ca2-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain CED85558 1.602612866 0.03649973 Molecular co-chaperone STI1 CED84694 1.608371962 0.02031649 Acyl-CoA synthetase CED85482 1.609224816 0.02478907 Vacuolar H-ATPase V1 sector, subunit E CDZ97501 1.609942116 0.04201509 p-loop containing nucleoside triphosphate hydrolase protein CED82887 1.614733759 0.02490967 Spliceosome subunit CED82373 1.617336057 0.01331504 Microtubule-binding protein involved in cell cycle control CED85608 1.627956219 0.01688491 Karyopherin (importin) beta 3 CDZ96772 1.633635875 0.0215727 dna-dependent rna polymerase ii second largest subunit CED82875 1.636243466 0.02878294 p-loop containing nucleoside triphosphate hydrolase protein CDZ96709 1.643701581 0.01276031 coatomer subunit gamma CED82718 1.653749043 0.02914553 Dehydrogenase kinase CDZ98379 1.654855765 0.03376189 mitochondrial pyruvate dehydrogenase e1 component beta subunit CDZ98664 1.664987389 0.00828925 glycoside hydrolase family 13 protein CDZ97227 1.676730007 0.01799604 nad-specific glutamate dehydrogenase CED84865 1.693137102 0.02925005 mitochondrial 50s ribosomal protein I3 CDZ97357 1.69780688 0.01583624 Ran GTPase-activating protein CDZ97274 1.703158642 0.04128817 fkbp-type peptidyl-prolyl cis-trans isomerase CED85510 1.704437647 0.03376189 hypothetical protein CDZ98568 1.707428296 0.01799604 60s ribosomal protein I19 CDZ97211 1.708555431 0.0195227 Small Nuclear ribonucleoprotein splicing factor CED84798 1.717516704 0.01276031 Mannosyltransferase CDZ98483 1.722444299 0.02914553 dutp pyrophosphatase CED82387 1.7250923 0.01109532 GST, gst CED84167 1.738514851 0.01583624 glutamate-trna ligase CDZ98702 1.740168961 0.01799604 mov34-domain-containing protein CED82610 1.741145108 0.01389815 mitochondrial nuclease CDZ97968 1.747047833 0.04735782 1,4-benzoquinone reductase-like CED85256 1.763029564 0.03716115 thiamine biosynthetic bifunctional enzyme CED83533 1.763463174 0.02889048 Protein of unknown function DUF3602 CDZ96990 1.765718629 0.01508991 upf0041-domain-containing protein CED83331 1.766842575 0.01575712 60s ribosomal protein I11 CED83746 1.777546216 0.03227504 hypothetical protein CDZ97319 1.785289098 0.02212097 Serine/threonine protein phosphatase 2A, regulatory subunit CDZ98624 1.788285059 0.03416979 argininosuccinate lyase CED85213 1.790475985 0.00905229 elongation factor 1 beta delta chain CED83192 1.803912495 0.02988308 bar-domain-containing protein CED84181 1.815242741 0.01154058 uridylate kinase CDZ96394 1.816977653 0.04455459 phosphatidylethanolamine n-methyltransferase CDZ98091 1.818027401 0.01389815 stomatin family protein CED83762 1.820314128 0.03448029 ubiquitin-conjugating enzyme CED85505 1.834634216 0.01109532 glycosyltransferase family 2 protein CED84800 1.838524109 0.04128817 hypothetical protein CED84682 1.839194002 0.03631055 Uncharacterized conserved protein CED83350 1.852972209 0.0163988 signal recognition particle protein CED85299 1.854408376 0.0110087 B-cell receptor-associated protein and related proteins CED82175 1.859771924 0.01109532 RNA-binding S4 domain CDZ97972 1.872513626 0.03376189 Drebrins and related actin binding proteins CED82401 1.880909466 0.03376189 small gtpase-binding protein CDZ98059 1.883204159 0.02914553 gtp cyclohydrolase i CED84722 1.892048206 0.02649992 ps16 protein CED85186 1.895077938 0.03376189 eukaryotic translation initiation factor 3 subunit 6 CED84608 1.909008315 0.00730273 hypothetical protein CDZ97780 1.93325344 0.01276031 hypothetical protein CDZ96174 1.939004053 0.04792978 Predicted hydrolase related to dienelactone hydrolase CED84225 1.953742748 0.02748415 Nuclear localization sequence binding protein CED83904 1.954139811 0.02914553 swi snf complex protein CDZ96983 1.969755024 0.01462763 hypothetical protein CED84490 1.981429905 0.01164179 gtp-binding protein ypt1 CDZ96924 1.982246388 0.0423797 ATPase, F0 complex, subunit H CED82203 1.986159712 0.02649992 metal resistance protein ycf1 CED83393 2.006367081 0.02513695 Outer membrane protein, MIM1/TOM13, mitochondrial CDZ96807 2.019757778 0.04399915 ubiquitin-protein ligase molybdopterin-converting factor CDZ97740 2.025807045 0.01799604 gtp-binding protein CDZ96605 2.027729754 0.00229207 Predicted mitochondrial carrier protein CDZ97834 2.031082152 0.0185739 rna-binding domain-containing protein CED82245 2.038685375 0.03019913 28 kda golgi snare protein CED83853 2.040204572 0.0070558 dead-domain-containing protein CED84219 2.042496249 0.01505725 -trehalose-phosphate synthase (udp-forming) CDZ96300 2.058119 0.02914553 ran protein binding protein CED82557 2.061553008 0.02748415 pkinase-domain-containing protein CED83678 2.063129603 0.03376189 hypothetical protein CDZ97373 2.067413471 0.0118088 Ribosome recycling factor domain CED82649 2.069249285 0.01109532 phosphatase CED85233 2.082511905 0.03019913 20s proteasome subunit CDZ96426 2.089091053 0.02549825 Nucleic acid-binding, OB-fold CED84077 2.089257714 0.03043844 atp-dependent rna helicase dbp5 CDZ97849 2.094972329 0.01408931 mRNA export protein (contains WD40 repeats) CDZ97098 2.104764907 0.02264306 Protein phosphatase 2A regulatory subunit A and related proteins CDZ96939 2.109542723 0.01649499 glutaminyl-trna synthetase CED85158 2.11839784 0.02914553 Prolactin regulatory element-binding protein/Protein transport protein SEC12p CDZ97144 2.124633505 0.01508991 Ribosome Assembly protein CED82147 2.141163817 0.02107155 C4-type Zn-finger protein CED82043 2.145468246 0.00521227 Exosomal 3-5 exoribonuclease complex subunit Rrp40 CED84757 2.14801929 0.02513695 Transcription regulator HTH, APSES-type DNA-binding domain CED82578 2.169428299 0.01222391 hypothetical protein CED84478 2.18760405 0.02800499 RIB7, arfC CED83083 2.18959859 0.04028758 60s ribosomal protein I12 CDZ98457 2.202848188 0.02878294 guanylate kinase CED85582 2.214308627 0.02344303 Predicted membrane protein CED82465 2.237750259 0.04122494 glycerol-3-phosphate o-acyltransferase CED85428 2.244873713 0.02203629 Cactin CED82211 2.259799008 0.01218618 translation initiation factor eif3 subunit CDZ97947 2.280864979 0.02064593 hypothetical protein CDZ96867 2.283479884 0.04861292 Biotin holocarboxylase synthetase/biotin-protein ligase CDZ97011 2.299863258 0.00164427 60s ribosomal protein I23 CDZ96733 2.311515815 0.04054781 Inositol monophosphatase CED84213 2.315052185 0.00816695 ras-domain-containing protein CED83529 2.316671565 0.00208188 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 CED82724 2.319660064 0.02026839 Ribosomal protein S24/S35, mitochondrial, conserved domain CED83468 2.36448386 0.04092267 Peptide methionine sulfoxide reductase CDZ96813 2.365957431 0.0188681 hypothetical protein CDZ97212 2.366141588 0.02365796 mitochondrial carrier CED83014 2.380596735 0.01583624 nad-dependent formate dehydrogenase CDZ98614 2.387150324 0.0238592 Molecular chaperone (DnaJ superfamily) CDZ97075 2.394628831 0.03019913 hypothetical protein CED82399 2.402453576 0.02264306 hypothetical protein CDZ98618 2.404051464 0.02649992 Immunoglobulin-like fold CED84473 2.413270708 0.00905229 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) CED82408 2.41927523 0.0195415 urease accessory protein CED84497 2.49808343 0.02856417 modular protein with glycoside hydrolase family 13 and glycosyltransferase family 5 domains CDZ98509 2.522541548 0.04122494 orotidine-5-phosphate decarboxylase CED85305 2.529111979 0.03376189 Phosphoprotein/predicted coiled-coil protein CED83414 2.530683213 0.02889048 nucleosome remodeling subunit caf1 nurf55 msi1 CDZ97207 2.557565145 0.04227026 Zinc finger, RING/FYVE/PHD-type CED83149 2.582726156 0.02212097 Prefoldin subunit 6, KE2 family CED83584 2.597234359 0.0238592 hypothetical protein CDZ98446 2.624539223 0.04976639 thioredoxin h CED83860 2.651386968 0.03649973 adf-like domain-containing protein CDZ98236 2.710676815 0.00361302 Alcohol dehydrogenase, class V CED84022 2.725408421 0.0296611 60s ribosomal protein I13 CDZ97924 2.727453323 0.03021911 hypothetical protein CED83962 2.754374803 0.02513695 glycoside hydrolase family 3 protein CED84144 2.826532427 0.02060729 Uncharacterized conserved protein CED82710 2.848141147 0.02649992 hypothetical protein spiRT_peptides 2.91938355 0.02549825 CED83656 2.929874549 0.02889048 Delta 9 fatty acid desaturase CDZ97129 2.950421262 0.01445079 Predicted regulator of rRNA gene transcription (MYB-binding protein) CDZ96235 2.965311288 0.03160153 Regulator of ribosome synthesis CDZ98212 2.984446161 0.00164427 WD40 repeat-containing protein CDZ96176 3.011422884 0.02221332 hexose transport-related protein CED83954 3.013895262 0.01541525 hypothetical protein CED82845 3.017036891 0.01649499 protein-histidine kinase CED83160 3.02768041 0.02344303 dna-directed rna polymerase ii subunit i CED85402 3.073843435 0.01168687 inositol-3-phosphate synthase CDZ98485 3.089642931 0.03416979 protein transport protein sec22 CED82033 3.191081754 0.04783144 hypothetical protein CDZ98496 3.283958645 0.01943629 hypothetical protein CED82966 3.393186712 0.0188681 Taurine catabolism dioxygenase TauD/TfdA CED82706 4.028618494 0.04727779 ATPase inhibitor, IATP, mitochondria CED84836 4.452914746 0.01439857 hypothetical protein CDZ96436 4.833255417 0.00066477 alcohol
TABLE-US-00019 TABLE 19 Protein log2FC adj. pvalue Protein name CED82765 4.231508 0.0223966 Quinonprotein alcohol dehydrogenase-like superfamily CDZ96711 3.818548 0.0001057 short-chain dehydrogenase CDZ96246 3.561085 0.1088072 NADH-ubiquinone oxidoreductase, 21 kDa subunit, N- terminal CDZ96507 3.488467 0.0608974 RmlC-like jelly roll fold CDZ98452 3.28816 0.0026732 hypothetical protein CED82658 3.161995 0.0056835 Deoxyribodipyrimidine photolyase/cryptochrome CDZ96283 3.050237 0.0858571 hypothetical protein CDZ97053 2.989734 0.0771834 40s ribosomal protein s15 CED82874 2.544518 0.0751553 gdp-I-fucose synthetase CED85319 2.31452 0.0859067 cysteine proteinase CDZ96948 2.310015 0.1080156 Protein phosphatase 1, regulatory subunit, and related proteins CED83221 2.288329 0.0494045 acn9-domain-containing protein CED85064 2.19761 0.0871441 actin depolymerizing factor CDZ98400 2.176685 0.0222833 proline iminopeptidase CDZ97081 2.10351 0.0433728 cyclophilin family peptidyl-prolyl cis-trans isomerase cyp2 CED83979 2.095009 0.042078 Flavonol reductase/cinnamoyl-CoA reductase CDZ98539 2.094727 0.0462864 SNARE protein Syntaxin 1 and related proteins CED82343 2.043645 0.1001054 serine threonine-protein phosphatase pp1 CDZ98291 1.972938 0.0126954 carboxypeptidase s CED85501 1.949842 0.0293803 nucleosome assembly protein CDZ96399 1.929302 0.0342256 Manganese/iron superoxide dismutase, C-terminal CDZ98540 1.883129 0.0146614 glycine hydroxymethyltransferase CDZ96534 1.875855 0.0313407 dihydroorotase CDZ97688 1.871465 0.0962559 glutaredoxin-related protein CED84517 1.856004 0.0514783 Protein required for normal rRNA processing CDZ98438 1.840714 0.1080156 hit family protein 1 CDZ97677 1.834903 0.0147147 Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 CED82582 1.820626 0.067386 20s proteasome subunit beta 3 CED82590 1.788278 0.0137624 Thioredoxin-like protein CDZ97777 1.77895 0.1232547 hypothetical protein CED82380 1.776832 0.17568 Predicted metal-binding protein CDZ97534 1.701239 0.0190789 Predicted dehydrogenase CDZ98470 1.682504 0.1568805 short-chain dehydrogenase CED85564 1.678797 0.0044979 Carbon-nitrogen hydrolase CED82723 1.676945 0.067386 Armadillo/beta-catenin-like repeat-containing protein CED82970 1.676565 0.0233499 40s ribosomal protein s22 CDZ97699 1.63503 0.1706431 hypothetical protein CDZ96647 1.60157 0.1214901 TPMT family CED84186 1.583796 0.0284367 dna-directed rna polymerases and iii kda polypeptide CED82344 1.533073 0.0512013 Glycosyl transferase, family 8-glycogenin CDZ96748 1.510136 0.1080156 short-chain dehydrogenase CDZ97010 1.506639 0.1232547 Coproporphyrinogen III oxidase CPO/HEM13 CDZ96544 1.475695 0.1378419 40s ribosomal protein s19 CED83819 1.457086 0.17568 adp-ribosylation factor CED85610 1.456115 0.0460038 Salt-sensitive 3-phosphoadenosine-5-phosphatase HAL2/SAL1 CED83449 1.448604 0.0419656 phytoene-beta carotene synthase CED83814 1.431916 0.1150853 acyl-oxidase CED83513 1.427821 0.0026732 phytoene dehydrogenase CED84484 1.41827 0.1309145 Peripheral-type benzodiazepine receptor and related proteins CED85105 1.417928 0.0552523 cytochrome-c oxidase chain vi precursor CDZ97542 1.417535 0.0560071 60s acidic ribosomal protein p0 CED84758 1.387994 0.0175187 ubc-like protein CED82388 1.380273 0.0126954 Cytochrome b5 CDZ97342 1.320494 0.1706431 Voltage-gated shaker-like K channel, subunit beta/KCNAB CED83339 1.297949 0.1706431 Phox/Bem1p CED83687 1.280689 0.0561539 mitochondrial protein CED83477 1.267639 0.1001054 Uncharacterized mRNA-associated protein RAP55 CED82722 1.25782 0.0126954 aspartyl aminopeptidase CED85079 1.246104 0.0982665 Cytokinin riboside 5-monophosphate phosphoribohydrolase LOG CDZ97430 1.235358 0.1175347 phosphomevalonate kinase CDZ97936 1.205686 0.1704925 Histone deacetylase complex, SIN3 component CDZ98639 1.203896 0.0503176 Aromatic amino acid aminotransferase and related proteins CED82942 1.194279 0.0876816 G protein beta subunit-like protein CED83940 1.151573 0.1305788 astaxanthin synthase CDZ96405 1.130725 0.1271256 phospho protein phosphatase ppz CED85454 1.126577 0.1740412 Putative metallopeptidase CED82502 1.126374 0.033781 nascent polypeptide-associated complex subunit beta CDZ96583 1.116411 0.0050139 ferrochelatase CDZ96773 1.090504 0.0297939 Translocase of outer mitochondrial membrane complex, subunit TOM20 CDZ96425 1.0814 0.0514783 catalase 1 CED83372 1.071293 0.106338 ATPase, F0 complex, subunit J CED85327 1.026518 0.0982665 carboxypeptidase s CDZ97990 1.014943 0.0763925 cwf21-domain-containing protein CED84048 1.014714 0.1715042 dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains CDZ96728 0.981699 0.0962559 Voltage-gated shaker-like K channel, subunit beta/KCNAB CDZ97775 0.956662 0.147114 serine carboxypeptidase CDZ96256 0.936691 0.0962559 EF-hand domain pair CED82360 0.933276 0.1042988 hypothetical protein CDZ98787 0.909721 0.1042988 Predicted transporter (major facilitator superfamily) CED84688 0.906571 0.1378419 Aldo/keto reductase family proteins CED83668 0.886642 0.0994446 26S proteasome regulatory complex, subunit RPN12/PSMD8 CDZ98576 0.88097 0.0947646 isocitrate dehydrogenase CED84981 0.870208 0.1309145 Iron/ascorbate family oxidoreductases CED82222 0.859981 0.026263 udp-glucose 4-epimerase CED83351 0.848954 0.0037331 abc transporter CED83536 0.799797 0.0152746 N-terminal acetyltransferase CED85376 0.797626 0.0376685 glyceraldehyde-3-phosphate dehydrogenase CED83362 0.79424 0.1348598 enolase CDZ97741 0.772249 0.0126954 prtase-like protein CDZ98574 0.770517 0.1709508 Protein of unknown function DUF4336 CDZ96706 0.754757 0.1158743 SNARE protein SED5/Syntaxin 5 CDZ97607 0.735133 0.0876816 er-associated protein catabolism-related protein CED85341 0.732743 0.1007998 Armadillo-type fold CED84995 0.728884 0.0270372 nadh-ubiquinone oxidoreductase 304 kda subunit precursor CED82933 0.727752 0.0137624 cndp dipeptidase CED83153 0.722774 0.0050139 aaa atpase CDZ98090 0.718506 0.1709508 adenylosuccinate lyase CED83950 0.717521 0.1437425 Beta-tubulin folding cofactor A CDZ96168 0.702449 0.0486467 26s proteasome subunit p45 CDZ96582 0.698475 0.0126954 26s proteasome subunit p45 CED82968 0.695251 0.0886062 Protein of unknown function DUF4449 CED82394 0.677589 0.1229557 protein transporter sec23 CDZ96849 0.673448 0.0126954 udp-glucuronic acid decarboxylase uxs1p CDZ97626 0.588913 0.1740412 FOG: RCC1 domain CDZ98437 0.553298 0.1295739 26s proteasome regulatory atpase rpt6 CED85458 0.552718 0.147114 methylenetetrahydrofolate dehydrogenase (nad) CED85255 0.518057 0.1605827 serine threonine-protein kinase CDZ97299 0.50117 0.1214901 prolyl oligopeptidase CDZ98246 0.498631 0.1224769 Nucleotide excision repair factor NEF2, RAD23 component CED85160 0.482933 0.0920586 prolyl-trna synthetase CDZ97055 0.461666 0.1715042 Predicted hydrolase related to dienelactone hydrolase CED84052 0.426502 0.1295739 snare protein ykt6 CED83796 0.420471 0.0763925 clathrin heavy chain CDZ96488 0.315547 0.0876816 sulfite reductase subunit beta CDZ97115 0.28538 0.1309145 adenylate kinase CED84486 0.28928 0.067386 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) CDZ96784 0.31858 0.1740412 nop domain-containing protein CED82089 0.32425 0.1740412 fthfs-domain-containing protein CED85467 0.32433 0.1194556 pre-mrna-processing-splicing factor CDZ98125 0.38528 0.1295739 alanine-trna ligase CDZ97113 0.40583 0.0039799 elongation factor 3 CDZ96742 0.44015 0.1362808 ck1 ck1 ck1-d protein kinase CDZ97730 0.44278 0.1363624 WD repeat protein CED84752 0.45235 0.147114 acetylglutamate kinase arg6 CED83281 0.4789 0.0993953 succinate-semialdehyde dehydrogenase CED83652 0.4896 0.1437425 electron-transferring-flavoprotein dehydrogenase CED83072 0.49434 0.1232547 probable eukaryotic translation initiation factor eif-3 CED83685 0.50318 0.0771834 heat shock protein 70 CED82409 0.50357 0.1214901 Nuclear pore complex component (sc Seh1) CED83447 0.50974 0.0871441 40s ribosomal protein s9 CED85459 0.51688 0.1305788 mrna export factor elf1 CED84188 0.51802 0.1780931 voltage-dependent ion-selective channel CDZ96380 0.53846 0.0840022 alpha-aminoadipate reductase lys1p CDZ98458 0.55225 0.0833734 hypothetical protein CDZ97062 0.55468 0.0486384 heat shock protein CED85365 0.56215 0.1221611 dna-directed rna polymerases i and iii 40 kda polypeptide CDZ98494 0.56276 0.0678771 eukaryotic translation initiation factor 3 subunit 8 CDZ98088 0.57308 0.0771834 p-loop containing nucleoside triphosphate hydrolase protein CED84980 0.58057 0.0366021 succinate-ligase (adp-forming) CED83665 0.58523 0.1082151 microtubule binding protein CDZ98525 0.58767 0.1671066 asparagine synthase (glutamine-hydrolyzing) CED82622 0.59254 0.0561539 aspartate aminotransferase CDZ97426 0.59941 0.1442533 eukaryotic translation initiation factor 3 subunit 6 CED83056 0.6003 0.0453207 nadh-ubiquinone oxidoreductase CED82811 0.60717 0.1150853 wd40 repeat-like protein CED85357 0.61544 0.0453661 glycosyltransferase family 35 protein CED82178 0.61759 0.175572 Predicted haloacid-halidohydrolase and related hydrolases CED82614 0.61903 0.0270372 pyruvate carboxylase CDZ97815 0.62037 0.1214901 arginyl-trna synthetase CED83286 0.62139 0.0336204 related to 2-hydroxy-3-oxopropionate reductase CDZ97020 0.62766 0.0898908 60s ribosomal protein I13a CDZ97800 0.6307 0.0876816 Uncharacterized protein CLU1/cluA CED82608 0.63681 0.1621596 20s proteasome subunit CED84183 0.63746 0.0404174 carbon-nitrogen hydrolase CED83611 0.6446 0.1739511 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) CDZ98039 0.64953 0.0560934 eukaryotic translation initiation factor 5b CED82220 0.65032 0.0636023 coatomer protein subunit alpha CDZ98017 0.67442 0.1739511 oligosaccharyl transferase stt3 subunit CDZ98852 0.67733 0.1359709 vacuolar atp synthase subunit d CED84347 0.68098 0.1436534 agc pka protein kinase CDZ98026 0.6936 0.147114 ef-hand CDZ96254 0.69919 0.1715042 phospholipid-translocating atpase CED82282 0.69928 0.0126954 polyadenylate-binding protein CED84522 0.70055 0.180053 Splicing factor U2AF, large subunit (RRM superfamily) CED85187 0.70282 0.1080156 Cullins CDZ96402 0.70365 0.067386 hypothetical protein CDZ97267 0.70539 0.0682198 pre-mrna-processing protein 45 CDZ97731 0.71288 0.008825 Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72 CED84243 0.71406 0.023715 gmp synthase CED84922 0.71629 0.0858571 Acetyl CoA acyltransferase 2 CDZ97556 0.71738 0.033781 hypothetical protein CED84878 0.72579 0.0771834 Transcriptional coactivator p100 CED82908 0.728 0.0514783 Metallopeptidase CED84394 0.73313 0.10398 Protein of unknown function DUF938 CED82377 0.73346 0.0695725 phosphoglucomutase CED83089 0.73572 0.1296054 NADH-cytochrome b-5 reductase CED82587 0.74374 0.1709508 hypothetical protein CED83181 0.75247 0.0851343 eukaryotic translation initiation factor 2 subunit alpha CED83463 0.75304 0.014415 atp-dependent rna helicase dhx8 CED82100 0.75699 0.1007998 Pyridoxalphosphate-dependent enzyme/predicted threonine synthase CED82249 0.76428 0.0614175 Lysophospholipase CED84107 0.77092 0.0561539 dead-domain-containing protein CED83380 0.78096 0.1080156 Oligosaccharyltransferase, alpha subunit (ribophorin I) CED84444 0.78774 0.0050139 nadh dehydrogenase CDZ97088 0.78881 0.0611706 gtp binding protein CED84659 0.79415 0.0830572 pentafunctional protein CDZ98670 0.79644 0.1359709 glycoside hydrolase family 13 protein CED85615 0.79864 0.1738004 HMG box-containing protein CED85600 0.81236 0.0851343 Acyl-CoA synthetase CED83469 0.81611 0.0692198 t-complex protein 1 CED84268 0.81772 0.1568805 Vacuolar protein sorting-associated protein CED83034 0.82036 0.0026732 threonyl-trna synthetase CED83688 0.82625 0.0075757 acetate--ligase CED82774 0.82864 0.056208 40s ribosomal protein s21 CED85021 0.82999 0.014415 pkinase-domain-containing protein CDZ96352 0.83139 0.016916 eukaryotic polypeptide chain release factor 3 CDZ98212 0.84074 0.1739511 WD40 repeat-containing protein CED82307 0.84346 0.126792 mevalonate kinase CED84984 0.84578 0.1150853 developmentally regulated gtp-binding protein CED82186 0.85369 0.1657161 Cell-cycle nuclear protein, contains WD-40 repeats CED82250 0.8599 0.095967 coatomer protein CDZ97948 0.86811 0.1089294 coatomer subunit delta CDZ98402 0.87314 0.0979159 RmlC-like jelly roll fold CDZ98765 0.89458 0.0608974 phenylalanyl-trna synthetase subunit beta CED84877 0.90761 0.1733975 Nuclear pore complex component (sc Nup85) CED84055 0.91098 0.0026732 Fatty acid synthase complex subunit beta CED84731 0.91787 0.0982665 cAMP-dependent protein kinase types I and II, regulatory subunit CED84608 0.92458 0.1043385 hypothetical protein CDZ97164 0.94756 0.0957369 Phosphomethylpyrimidine kinase CDZ96172 0.95622 0.1229731 translational regulator gcn20-like abc transporter CDZ98173 0.95779 0.0692198 methionyl-trna synthetase CED85540 0.96249 0.0109769 60s ribosomal protein I20 CDZ96447 0.96398 0.0374233 related to ste23-metalloprotease involved in a- factor processing CED85618 0.96416 0.1173322 glutamate dehydrogenase (nadp ) CDZ97095 0.96481 0.0222833 Uncharacterized enzymes related to aldose 1- epimerase CDZ97844 0.9676 0.0871441 glycerol-3-phosphate dehydrogenase CDZ96270 0.96864 0.0026273 phosphoglycerate kinase CDZ96943 0.96912 0.0495848 Peptidyl-prolyl cis-trans isomerase CED84004 0.97124 0.1715042 arm repeat-containing protein CED84854 0.97158 0.0062306 heat shock protein CED82490 0.97251 0.042078 plasma membrane h( )-atpase 1 CED84115 0.97573 0.0771834 2-hydroxyacyl-lyase CDZ96746 0.97629 0.0751553 dihydrolipoyllysine-residue acetyltransferase CED84246 0.98073 0.0175187 citrate synthase CED84490 0.98102 0.1512838 gtp-binding protein ypt1 CED83658 0.98434 0.1491807 Microtubule-associated protein CDZ97241 0.98541 0.0167343 mitochondrial nad-homo-isocitrate dehydrogenase CED83932 0.98644 0.1080156 Phosphatidylserine decarboxylase CED85039 0.99117 0.067386 C-24 methyl transferase CDZ98702 1.00312 0.147114 mov34-domain-containing protein CED82008 1.00466 0.0699152 Ca2-dependent lipid-binding protein CLB1/vesicle protein vp115 CED84681 1.01627 0.0503176 arm repeat-containing protein CED84622 1.01707 0.1438478 chromatin remodelling complex atpase chain CDZ97595 1.01773 0.133613 glycoside hydrolase family 32 protein CDZ96916 1.018 0.033781 imidazoleglycerol phosphate synthase CDZ97922 1.02091 0.0560934 histidyl-trna synthetase CED82181 1.02603 0.010389 nadh-cytochrome b5 reductase CED85375 1.03089 0.1718815 3-deoxy-7-phosphoheptulonate synthase CDZ98718 1.03454 0.0061469 coatomer beta subunit CDZ98706 1.03631 0.0420255 Phosphatidylinositol transfer protein SEC14 and related proteins CED83084 1.03953 0.1289963 F1-ATP synthase assembly protein CDZ97544 1.04039 0.1512838 40s ribosomal protein s20 CED85505 1.04548 0.1017034 glycosyltransferase family 2 protein CED85306 1.05206 0.0561539 Allantoicase CED83834 1.0581 0.1080156 mfs monosaccharide transporter CED82858 1.06144 0.1232547 hexokinase CED85483 1.06172 0.0499431 40s ribosomal protein s6 CED83589 1.06427 0.033781 ATP-dependent RNA helicase pitchoune CDZ97357 1.06568 0.1080156 Ran GTPase-activating protein CED84737 1.07129 0.0146614 nad binding dehydrogenase CED83001 1.07233 0.0026732 heat shock protein 60 ame: full = 60 kda chaperonin CED83179 1.07579 0.0137624 Perilipin CDZ97007 1.08006 0.0794147 sugar transporter CED82373 1.08484 0.0778048 Microtubule-binding protein involved in cell cycle control CED82356 1.08878 0.1232547 GDP-mannose pyrophosphorylase CED83350 1.09326 0.1295739 signal recognition particle protein CED83064 1.09776 0.0126954 glutamate-5-semialdehyde dehydrogenase CED83338 1.11182 0.1715042 protein phosphatase CED85589 1.11338 0.1017034 Predicted proline-serine-threonine phosphatase- interacting protein (PSTPIP) CED83853 1.11353 0.0735099 dead-domain-containing protein CDZ98315 1.11958 0.0490554 Ribosomal protein S5 CDZ96576 1.12389 0.008825 sly1 vesicle trafficking sec1-like protein CED83290 1.1313 0.0161918 trehalose 6-phosphate phosphatase CED82302 1.13258 0.1541232 WD40 repeat-containing protein CED84865 1.14211 0.1563611 mitochondrial 50s ribosomal protein I3 CED82772 1.14646 0.130641 Histidine-specific methyltransferase, SAM- dependent CED83357 1.14982 0.1568805 60s ribosomal protein I7 CED84941 1.15648 0.0427497 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) CED84219 1.15953 0.130641 -trehalose-phosphate synthase (udp-forming) CED84803 1.16039 0.0871441 imp dehydrogenase CED82043 1.17161 0.0643306 Exosomal 3-5 exoribonuclease complex subunit Rrp40 CDZ97030 1.17282 0.0026732 succinate:fumarate antiporter CDZ97070 1.1786 0.1706431 glutathione peroxidase CED84796 1.18436 0.0794704 Delta 12 fatty acid desaturase CED82849 1.19242 0.067386 transaldolase CED82649 1.19995 0.0993953 phosphatase CED84960 1.21113 0.0126954 gtp binding protein 4 CED82693 1.21672 0.1706431 arm repeat-containing protein CED83746 1.22831 0.1583372 hypothetical protein CDZ96477 1.23733 0.0037331 ornithine carbamoyltransferase CDZ96620 1.238 9.181E05 Fatty acid synthase complex subunit alpha CED83014 1.24085 0.1715042 nad-dependent formate dehydrogenase CDZ96709 1.24506 0.0509018 coatomer subunit gamma CDZ97588 1.24644 0.0692198 RP-S18, MRPS18, rpsR CED83573 1.24929 0.0470041 UDP-N-acetylglucosamine pyrophosphorylase CDZ98425 1.25161 0.0147147 aldehyde dehydrogenase CDZ98564 1.25786 0.0289389 pyruvate kinase CED82578 1.26332 0.1079024 hypothetical protein CED84238 1.26644 0.0123918 gtp-binding protein ypt3 CED83765 1.27793 0.008825 carbamoyl-phosphate synthase CED84213 1.29049 0.0771834 ras-domain-containing protein CDZ98136 1.30498 0.1706431 Vesicle trafficking protein Sec1 CED82875 1.33021 0.0957369 p-loop containing nucleoside triphosphate hydrolase protein CDZ97947 1.34958 0.157889 hypothetical protein CED83361 1.35397 0.0139816 dihydroxy-acid dehydratase CDZ97373 1.36287 0.0751553 Ribosome recycling factor domain CDZ97245 1.37 0.0062306 acetyl-hydrolase CED84039 1.39997 0.0961632 Glycosyl transferase, family 1 CED84809 1.40948 0.0147147 mago nashi CDZ98813 1.41592 0.17568 WD40/YVTN repeat-like-containing domain CED83572 1.41975 0.0141757 atp-citrate synthase CED85129 1.44133 0.0554217 isocitrate lyase CED82387 1.44764 0.0294131 GST, gst CED82450 1.46422 0.0783197 amidophosphoribosyltransferase CDZ97923 1.47301 0.1097654 d-arabinitol 2-dehydrogenase CED84763 1.4734 0.0957766 SPCS2, SPC2 CDZ98236 1.47606 0.0499431 Alcohol dehydrogenase, class V CED84181 1.47713 0.0342256 uridylate kinase CED83904 1.48705 0.1150287 swi snf complex protein CED82339 1.52561 0.1709508 Protein involved in Snf1 protein kinase complex assembly CDZ97501 1.5258 0.087982 p-loop containing nucleoside triphosphate hydrolase protein CED85216 1.54086 0.0032648 Aromatic amino acid aminotransferase and related proteins CDZ96990 1.56918 0.0342256 upf0041-domain-containing protein CED83533 1.58921 0.0699152 Protein of unknown function DUF3602 CDZ97740 1.61523 0.0614175 gtp-binding protein CED83642 1.61929 0.1378419 Uncharacterized conserved protein CED83331 1.63302 0.0314857 60s ribosomal protein I11 CED84705 1.63799 0.0270372 arginine biosynthesis protein CED82059 1.63961 0.0026732 fk506-binding protein 2 CED83630 1.64796 0.0037331 glucose-6-phosphate isomerase CDZ97129 1.67776 0.1289963 Predicted regulator of rRNA gene transcription (MYB-binding protein) CED83333 1.68454 0.0026273 pyruvate decarboxylase CED84473 1.68967 0.0457587 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) CDZ97012 1.69367 0.0037331 alcohol CDZ98664 1.71814 0.0075757 glycoside hydrolase family 13 protein CED83236 1.73513 0.0026273 epsilon dna polymerase CDZ97011 1.73773 0.0050139 60s ribosomal protein I23 CED83452 1.78054 0.0503176 glycoside hydrolase family 13 protein CED84972 1.79085 0.008062 NADH-dehydrogenase (ubiquinone) CDZ97924 1.81654 0.1672259 hypothetical protein CED84831 1.82825 0.1089294 -like helicase 1 CDZ97488 1.87594 0.0126954 isocitrate dehydrogenase CDZ98179 1.89763 0.0005055 Acetyl CoA carboxylase CED82102 1.90183 0.0274228 tetrapyrrole biosynthesis porphobilinogen synthase CED83672 1.91539 0.0751553 hypothetical protein CED84851 1.96978 0.0345283 acetylornithine aminotransferase CED84556 1.97107 0.0050139 phosphoketolase CDZ96541 1.97312 0.0993953 atp phosphoribosyltransferase CED84497 1.97839 0.0993953 modular protein with glycoside hydrolase family 13 and glycosyltransferase family 5 domains CED85401 2.09905 0.0122113 CDZ96394 2.10898 0.0503176 phosphatidylethanolamine n-methyltransferase CED83656 2.11939 0.1273922 Delta 9 fatty acid desaturase CED82203 2.24415 0.0289389 metal resistance protein ycf1 CED83962 2.41422 0.0666375 glycoside hydrolase family 3 protein CDZ96382 2.78513 0.008825 glycoside hydrolase family 32 protein CED82966 3.24281 0.0345283 Taurine catabolismdioxygenase TauD/TfdA CDZ96436 3.52954 0.0032648 alcohol CED83529 4.59152 6.361E05 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31
TABLE-US-00020 TABLE 20 CDS SEQ Accession ID NO Table(s) Variation(s) CDZ98521 14894 Table 14 and Table 15 Z.sub.1; Z.sub.21; V.sub.1 CED83134 16402 Table 14 only Z.sub.2; Z.sub.14 CED80058 13437 Table 14 and Table 15 Z.sub.3; Z.sub.22; V.sub.5; V.sub.6; V.sub.7 CED80056 13605 Table 14 and Table 15 Z.sub.4; V.sub.10; V.sub.11 CDZ96150 15263 Table 14 and Table 15 Z.sub.5; V.sub.15; V.sub.16; V.sub.17; V.sub.18 CDZ96151 15929 Table 14 and Table 15 Z.sub.6; Z.sub.7; V.sub.21; V.sub.22; V.sub.23; V.sub.24; V.sub.25 CDZ96152 17082 Table 14 and Table 15 Z.sub.8; V.sub.12 CDZ96153 12953 Table 14 only Z.sub.9; Z.sub.10 CED80060 13445 Table 14 only Z.sub.11 CED80061 13989 Table 14 and Table 15 Z.sub.12; Z.sub.13; V.sub.13; V.sub.14; V.sub.26 CED83656 17215 Table 14 only Z.sub.15 CED83814 17373 Table 14 only Z.sub.16 CDZ96789 18649 Table 14 only Z.sub.17 CDZ97186 19046 Table 14 and Table 15 Z.sub.18; V.sub.2 CDZ98193 13853 Table 14 and Table 15 Z.sub.19; V.sub.3 CDZ98468 14841 Table 14 only Z.sub.20 CDZ96332 15265 Table 14 and Table 15 Z.sub.23; V.sub.4 CED83975 17534 Table 14 only Z.sub.24 CDZ98804 15177 Table 14 only Z.sub.25 CDZ96154 13440 Table 15 only V.sub.8; V.sub.9 CDZ96333 15928 Table 15 only V.sub.19; V.sub.20