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BIVALENT, BISPECIFIC BINDING PROTEINS FOR PREVENTION OR TREATMENT OF HIV INFECTION

20250312475 ยท 2025-10-09

    Inventors

    Cpc classification

    International classification

    Abstract

    Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.

    Claims

    1-139. (canceled)

    140: A bivalent, bispecific binding protein that specifically binds to two different HIV-1 Env protein epitopes, wherein the bivalent, bispecific binding protein comprises a first and a second binding site; wherein the first binding site comprises V.sub.H1 and V.sub.L1, wherein V.sub.H1 is a first immunoglobulin heavy chain variable domain that comprises the amino acid sequence of SEQ ID NO:506, and wherein V.sub.L1 is a first immunoglobulin light chain variable domain that comprises the amino acid sequence of SEQ ID NO:519; and wherein the second binding site comprises V.sub.H2 and V.sub.L2, wherein V.sub.H2 is a second immunoglobulin heavy chain variable domain that comprises the amino acid sequence of SEQ ID NO: 504, and wherein V.sub.L2 is a second immunoglobulin light chain variable domain that comprises the amino acid sequence of SEQ ID NO: 518.

    141: A bivalent, bispecific binding protein that specifically binds to two different HIV-1 Env protein epitopes, wherein the bivalent, bispecific binding protein comprises a first and a second binding site; wherein the first binding site comprises V.sub.H1 and V.sub.L1, wherein V.sub.H1 is a first immunoglobulin heavy chain variable domain that comprises the amino acid sequence of SEQ ID NO: 503, and wherein V.sub.L1 is a first immunoglobulin light chain variable domain that comprises the amino acid sequence of SEQ ID NO: 513; and wherein the second binding site comprises V.sub.H2 and V.sub.L2, wherein V.sub.H2 is a second immunoglobulin heavy chain variable domain that comprises the amino acid sequence of SEQ ID NO: 506, and wherein V.sub.L2 is a second immunoglobulin light chain variable domain that comprises the amino acid sequence of SEQ ID NO: 519.

    142: A bivalent, bispecific binding protein that specifically binds to two different HIV-1 Env protein epitopes, wherein the bivalent, bispecific binding protein comprises a first and a second binding site; wherein the first binding site comprises V.sub.H1 and V.sub.L1, wherein V.sub.H1 is a first immunoglobulin heavy chain variable domain that comprises the amino acid sequence of SEQ ID NO: 506, and wherein V.sub.L1 is a first immunoglobulin light chain variable domain that comprises the amino acid sequence of SEQ ID NO: 519; and wherein the second binding site comprises V.sub.H2 and V.sub.L2, wherein V.sub.H2 is a second immunoglobulin heavy chain variable domain that comprises the amino acid sequence of SEQ ID NO: 503, and wherein V.sub.L2 is a second immunoglobulin light chain variable domain that comprises the amino acid sequence of SEQ ID NO: 513.

    143: An isolated nucleic acid molecule comprising a nucleotide sequence encoding the bivalent, bispecific binding protein of claim 140.

    144: An isolated nucleic acid molecule comprising a nucleotide sequence encoding the bivalent, bispecific binding protein of claim 141.

    145: An isolated nucleic acid molecule comprising a nucleotide sequence encoding the bivalent, bispecific binding protein of claim 142.

    146. An expression vector comprising the nucleic acid molecule of claim 143.

    147. An expression vector comprising the nucleic acid molecule of claim 144.

    148. An expression vector comprising the nucleic acid molecule of claim 145.

    149. An isolated host cell comprising the nucleic acid molecule of claim 143 or an expression vector comprising the nucleic acid molecule of claim 143.

    150. An isolated host cell comprising the nucleic acid molecule of claim 144 or an expression vector comprising the nucleic acid molecule of claim 144.

    151. An isolated host cell comprising the nucleic acid molecule of claim 145 or an expression vector comprising the nucleic acid molecule of claim 145.

    152. A method of producing a bivalent, bispecific binding protein, the method comprising: a) culturing the host cell of claim 149 under conditions such that the host cell expresses the bivalent, bispecific binding protein; and b) isolating the bivalent, bispecific binding protein from the host cell.

    153. A method of producing a bivalent, bispecific binding protein, the method comprising: a) culturing the host cell of claim 150 under conditions such that the host cell expresses the bivalent, bispecific binding protein; and b) isolating the bivalent, bispecific binding protein from the host cell.

    154. A method of producing a bivalent, bispecific binding protein, the method comprising: a) culturing the host cell of claim 151 under conditions such that the host cell expresses the bivalent, bispecific binding protein; and b) isolating the bivalent, bispecific binding protein from the host cell.

    155. A method of preventing and/or treating HIV infection in a patient comprising administering to the patient a therapeutically effective amount of the bivalent, bispecific binding protein of claim 140.

    156. A method of preventing and/or treating HIV infection in a patient comprising administering to the patient a therapeutically effective amount of the bivalent, bispecific binding protein of claim 141.

    157. A method of preventing and/or treating HIV infection in a patient comprising administering to the patient a therapeutically effective amount of the bivalent, bispecific binding protein of claim 142.

    Description

    BRIEF DESCRIPTION OF THE DRAWINGS

    [0291] FIGS. 1A-D show schematic representations of trispecific binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind three different epitopes on one or more antigens, wherein a first pair of polypeptides possess dual variable domains having a cross-over orientation forming two antigen binding sites (comprising V.sub.H1-V.sub.L1 and V.sub.H2-V.sub.L2) and wherein a second pair of polypeptides possess a single antigen binding site (comprising V.sub.H3-V.sub.L3), in accordance with some embodiments. FIG. 1A shows a trispecific binding protein comprising a knobs-into-holes modification, wherein the knob is on the first pair of polypeptides. FIG. 1B shows a trispecific binding protein comprising a knobs-into-holes modification, wherein the knob is on the second pair of polypeptides. FIG. 1C shows the orientation of variable domains on the polypeptide chains, and the knob/hole orientation for binding proteins 1-31 shown in Tables 1 and 2. Heavy chain A (e.g., a third polypeptide chain of the present disclosure) indicates the variable domain of heavy chain A. Light chain A (e.g., a fourth polypeptide chain of the present disclosure) indicates the variable domain of light chain A. Heavy chain B (e.g., a second polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of heavy chain B. Light chain B (e.g., a first polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of light chain B.

    [0292] FIG. 1D shows the orientation of variable domains on the polypeptide chains, and the knob/hole orientation for binding proteins 32-53 shown in Tables 1 and 2. Heavy chain A (e.g., a third polypeptide chain of the present disclosure) indicates the variable domain of heavy chain A. Light chain A (e.g., a fourth polypeptide chain of the present disclosure) indicates the variable domain of light chain A. Heavy chain B (e.g., a second polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of heavy chain B. Light chain B (e.g., a first polypeptide chain of the present disclosure) indicates variable domain 1 and variable domain 2 of light chain B.

    [0293] FIGS. 2A-B show purification of three trispecific binding proteins first using affinity chromatography, and then using preparative size exclusion chromatography. FIG. 2A shows the elution profile of the trispecific binding proteins during purification using protein A affinity chromatography. FIG. 2B shows purification of monomeric proteins by Superdex200 size exclusion chromatography.

    [0294] FIGS. 3A-B show purification of the MPER Ab, CD4BS Ab b, and V1/V2 directed Ab a parental antibodies first using affinity chromatography, and then using preparative size exclusion chromatography. FIG. 3A shows the elution profile of the parental antibodies during purification using protein A affinity chromatography. FIG. 3B shows purification of monomeric proteins by Superdex200 size exclusion chromatography.

    [0295] FIGS. 4A-B show the size exclusion chromatography profiles of bispecific and trispecific binding proteins. FIG. 4A shows the size exclusion chromatography profiles of the bispecific binding proteins. FIG. 4B shows the size exclusion chromatography profiles of the trispecific binding proteins.

    [0296] FIG. 5 shows the Biacore sensograms of the binding kinetics of three trispecific binding proteins and the parental MPER Ab antibody for an HIV gp41-derived peptide (the MPER binding site), as assessed by the standard Biacore-based kinetic assay.

    [0297] FIG. 6 shows the Biacore sensograms of the binding kinetics of three trispecific binding proteins and the parental CD4BS Ab b antibody for recombinant HIV gp120, as assessed by the standard Biacore-based kinetic assay.

    [0298] FIG. 7 shows the results of a pharmacokinetic (PK) study of the indicated proteins after intravenous (IV) injection in rhesus macaques.

    [0299] FIGS. 8A-8B show schematic representations of trispecific T-cell engagers, in accordance with some embodiments. The binding sites are indicated by the dotted circles.

    [0300] FIG. 9 shows binding properties of the trispecific binding proteins Binding Protein 32 and CD3CD28/CD4BS Ab b to CD3 (CD3E represents CD3epsilon protein; CD3D represents CD3delta protein), CD28, and Resurfaced Stabilized Core 3 (RSC3) protein of gp120, as well as a negative control (human IgG).

    [0301] FIG. 10 shows CD8 T-cell activation using the trispecific proteins Binding Protein 32 and CD3CD28/CD4BS Ab b compared to the parental CD4BS IgG4 antibody, as well as a negative control (No mAb).

    [0302] FIG. 11 shows CD4 T-cell activation using the trispecific proteins Binding Protein 32 and CD3CD28/CD4BS Ab b compared to the parental CD4BS IgG4 antibody, as well as a negative control (No mAb).

    [0303] FIG. 12 shows CD3 downregulation after T cell activation by the trispecific proteins Binding Protein 32 and CD3CD28/CD4BS Ab b compared to the parental CD4BS IgG4 antibody, as well as a negative control (No mAb).

    [0304] FIGS. 13A-C show fluorescence-activated cell sorting (FACS)-based cytotoxicity assay results for trispecific binding proteins against latently infected HIV-1 T cells. FIG. 13A shows the results for trispecific binding proteins incubated with CEM-BaL cells. FIG. 13B shows the results for trispecific binding proteins incubated with ACH2 cells. FIG. 13C shows the results for trispecific binding proteins incubated with J1.1 cells.

    DETAILED DESCRIPTION

    [0305] The present disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind to one or more human immunodeficiency virus (HIV) target proteins and/or one or more T-cell receptor target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain.

    [0306] The following description sets forth exemplary methods, parameters, and the like. It should be recognized, however, that such description is not intended as a limitation on the scope of the present disclosure but is instead provided as a description of exemplary embodiments.

    Definitions

    [0307] As utilized in accordance with the present disclosure, the following terms, unless otherwise indicated, shall be understood to have the following meanings. Unless otherwise required by context, singular terms shall include pluralities and plural terms shall include the singular.

    [0308] The term polynucleotide as used herein refers to single-stranded or double-stranded nucleic acid polymers of at least 10 nucleotides in length. In certain embodiments, the nucleotides comprising the polynucleotide can be ribonucleotides or deoxyribonucleotides or a modified form of either type of nucleotide. Such modifications include base modifications such as bromuridine, ribose modifications such as arabinoside and 2,3-dideoxyribose, and internucleotide linkage modifications such as phosphorothioate, phosphorodithioate, phosphoroselenoate, phosphorodiselenoate, phosphoroanilothioate, phoshoraniladate and phosphoroamidate. The term polynucleotide specifically includes single-stranded and double-stranded forms of DNA.

    [0309] An isolated polynucleotide is a polynucleotide of genomic, cDNA, or synthetic origin or some combination thereof, which: (1) is not associated with all or a portion of a polynucleotide in which the isolated polynucleotide is found in nature, (2) is linked to a polynucleotide to which it is not linked in nature, or (3) does not occur in nature as part of a larger sequence.

    [0310] An isolated polypeptide is one that: (1) is free of at least some other polypeptides with which it would normally be found, (2) is essentially free of other polypeptides from the same source, e.g., from the same species, (3) is expressed by a cell from a different species. (4) has been separated from at least about 50 percent of polynucleotides, lipids, carbohydrates, or other materials with which it is associated in nature, (5) is not associated (by covalent or noncovalent interaction) with portions of a polypeptide with which the isolated polypeptide is associated in nature, (6) is operably associated (by covalent or noncovalent interaction) with a polypeptide with which it is not associated in nature, or (7) does not occur in nature. Such an isolated polypeptide can be encoded by genomic DNA, cDNA, mRNA or other RNA, of synthetic origin, or any combination thereof. Preferably, the isolated polypeptide is substantially free from polypeptides or other contaminants that are found in its natural environment that would interfere with its use (therapeutic, diagnostic, prophylactic, research or otherwise).

    [0311] Naturally occurring antibodies typically comprise a tetramer. Each such tetramer is typically composed of two identical pairs of polypeptide chains, each pair having one full-length light chain (typically having a molecular weight of about 25 kDa) and one full-length heavy chain (typically having a molecular weight of about 50-70 kDa). The terms heavy chain and light chain as used herein refer to any immunoglobulin polypeptide having sufficient variable domain sequence to confer specificity for a target antigen. The amino-terminal portion of each light and heavy chain typically includes a variable domain of about 100 to 110 or more amino acids that typically is responsible for antigen recognition. The carboxy-terminal portion of each chain typically defines a constant domain responsible for effector function. Thus, in a naturally occurring antibody, a full-length heavy chain immunoglobulin polypeptide includes a variable domain (V.sub.H) and three constant domains (C.sub.H1, C.sub.H2, and C.sub.H3), wherein the V.sub.H domain is at the amino-terminus of the polypeptide and the C.sub.H3 domain is at the carboxyl-terminus, and a full-length light chain immunoglobulin polypeptide includes a variable domain (V.sub.L) and a constant domain (C.sub.L), wherein the V.sub.L domain is at the amino-terminus of the polypeptide and the C.sub.L domain is at the carboxyl-terminus.

    [0312] Human light chains are typically classified as kappa and lambda light chains, and human heavy chains are typically classified as mu, delta, gamma, alpha, or epsilon, and define the antibody's isotype as IgM, IgD, IgG, IgA, and IgE, respectively. IgG has several subclasses, including, but not limited to, IgG1, IgG2, IgG3, and IgG4. IgM has subclasses including, but not limited to, IgM1 and IgM2. IgA is similarly subdivided into subclasses including, but not limited to, IgA1 and IgA2. Within full-length light and heavy chains, the variable and constant domains typically are joined by a J region of about 12 or more amino acids, with the heavy chain also including a D region of about 10 more amino acids. See, e.g., FUNDAMENTAL IMMUNOLOGY (Paul, W., ed., Raven Press, 2nd ed., 1989), which is incorporated by reference in its entirety for all purposes. The variable regions of each light/heavy chain pair typically form an antigen binding site. The variable domains of naturally occurring antibodies typically exhibit the same general structure of relatively conserved framework regions (FR) joined by three hypervariable regions, also called complementarity determining regions or CDRs. The CDRs from the two chains of each pair typically are aligned by the framework regions, which may enable binding to a specific epitope. From the amino-terminus to the carboxyl-terminus, both light and heavy chain variable domains typically comprise the domains FR1, CDR1, FR2, CDR2, FR3, CDR3, and FR4.

    [0313] The term CDR set refers to a group of three CDRs that occur in a single variable region capable of binding the antigen. The exact boundaries of these CDRs have been defined differently according to different systems. The system described by Kabat (Kabat et al., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST (National Institutes of Health, Bethesda, Md. (1987) and (1991)) not only provides an unambiguous residue numbering system applicable to any variable region of an antibody, but also provides precise residue boundaries defining the three CDRs. These CDRs may be referred to as Kabat CDRs. Chothia and coworkers (Chothia and Lesk, 1987, J. Mol. Biol. 196: 901-17; Chothia et al., 1989, Nature 342: 877-83) found that certain sub-portions within Kabat CDRs adopt nearly identical peptide backbone conformations, despite having great diversity at the level of amino acid sequence. These sub-portions were designated as L1, L2, and L3 or H1, H2, and H3 where the L and the H designates the light chain and the heavy chain regions, respectively. These regions may be referred to as Chothia CDRs, which have boundaries that overlap with Kabat CDRs. Other boundaries defining CDRs overlapping with the Kabat CDRs have been described by Padlan, 1995, FASEB J. 9: 133-39: MacCallum, 1996, J. Mol. Biol. 262(5): 732-45; and Lefranc, 2003, Dev. Comp. Immunol. 27: 55-77. Still other CDR boundary definitions may not strictly follow one of the herein systems, but will nonetheless overlap with the Kabat CDRs, although they may be shortened or lengthened in light of prediction or experimental findings that particular residues or groups of residues or even entire CDRs do not significantly impact antigen binding. The methods used herein may utilize CDRs defined according to any of these systems, although certain embodiments use Kabat or Chothia defined CDRs. Identification of predicted CDRs using the amino acid sequence is well known in the field, such as in Martin, A. C. Protein sequence and structure analysis of antibody variable domains. In Antibody Engineering, Vol. 2. Kontermann R., Dbel S., eds. Springer-Verlag, Berlin, p. 33-51 (2010). The amino acid sequence of the heavy and/or light chain variable domain may be also inspected to identify the sequences of the CDRs by other conventional methods, e.g., by comparison to known amino acid sequences of other heavy and light chain variable regions to determine the regions of sequence hypervariability. The numbered sequences may be aligned by eye, or by employing an alignment program such as one of the CLUSTAL suite of programs, as described in Thompson, 1994. Nucleic Acids Res. 22: 4673-80. Molecular models are conventionally used to correctly delineate framework and CDR regions and thus correct the sequence-based assignments.

    [0314] The term Fc as used herein refers to a molecule comprising the sequence of a non-antigen-binding fragment resulting from digestion of an antibody or produced by other means, whether in monomeric or multimeric form, and can contain the hinge region. The original immunoglobulin source of the native Fc is preferably of human origin and can be any of the immunoglobulins, although IgG1 and IgG2 are preferred. Fc molecules are made up of monomeric polypeptides that can be linked into dimeric or multimeric forms by covalent (i.e., disulfide bonds) and non-covalent association. The number of intermolecular disulfide bonds between monomeric subunits of native Fc molecules ranges from 1 to 4 depending on class (e.g., IgG, IgA, and IgE) or subclass (e.g., IgG1, IgG2, IgG3, IgA1, and IgGA2). One example of a Fc is a disulfide-bonded dimer resulting from papain digestion of an IgG. The term Fc as used herein is generic to the monomeric, dimeric, and multimeric forms.

    [0315] A F(ab) fragment typically includes one light chain and the V.sub.H and C.sub.H1 domains of one heavy chain, wherein the V.sub.H-C.sub.H1 heavy chain portion of the F(ab) fragment cannot form a disulfide bond with another heavy chain polypeptide. As used herein, a F(ab) fragment can also include one light chain containing two variable domains separated by an amino acid linker and one heavy chain containing two variable domains separated by an amino acid linker and a C.sub.H1 domain.

    [0316] A F(ab) fragment typically includes one light chain and a portion of one heavy chain that contains more of the constant region (between the C.sub.H1 and C.sub.H2 domains), such that an interchain disulfide bond can be formed between two heavy chains to form a F(ab).sub.2 molecule.

    [0317] The term binding protein as used herein refers to a non-naturally occurring (or recombinant or engineered) molecule that specifically binds to at least one target antigen, and which comprises four polypeptide chains that form at least three antigen binding sites, wherein a first polypeptide chain has a structure represented by the formula:

    ##STR00045## [0318] and a second polypeptide chain has a structure represented by the formula:

    ##STR00046## [0319] and a third polypeptide chain has a structure represented by the formula:

    ##STR00047## [0320] and a fourth polypeptide chain has a structure represented by the formula:

    ##STR00048## [0321] wherein: [0322] V.sub.L1 is a first immunoglobulin light chain variable domain; [0323] V.sub.L2 is a second immunoglobulin light chain variable domain; [0324] V.sub.L3 is a third immunoglobulin light chain variable domain; [0325] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0326] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0327] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0328] C.sub.L is an immunoglobulin light chain constant domain; [0329] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; and [0330] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers; [0331] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0332] A recombinant molecule is one that has been prepared, expressed, created, or isolated by recombinant means.

    [0333] One embodiment of the disclosure provides binding proteins having biological and immunological specificity to between one and three target antigens. Another embodiment of the disclosure provides nucleic acid molecules comprising nucleotide sequences encoding polypeptide chains that form such binding proteins. Another embodiment of the disclosure provides expression vectors comprising nucleic acid molecules comprising nucleotide sequences encoding polypeptide chains that form such binding proteins. Yet another embodiment of the disclosure provides host cells that express such binding proteins (i.e., comprising nucleic acid molecules or vectors encoding polypeptide chains that form such binding proteins).

    [0334] The term swapability as used herein refers to the interchangeability of variable domains within the binding protein format and with retention of folding and ultimate binding affinity. Full swapability refers to the ability to swap the order of both V.sub.H1 and V.sub.H2 domains, and therefore the order of V.sub.L1 and V.sub.L2 domains, in the polypeptide chain of formula I or the polypeptide chain of formula II (i.e., to reverse the order) while maintaining full functionality of the binding protein as evidenced by the retention of binding affinity. Furthermore, it should be noted that the designations V.sub.H and V.sub.L refer only to the domain's location on a particular protein chain in the final format. For example, V.sub.H1 and V.sub.H2 could be derived from V.sub.L1 and V.sub.L2 domains in parent antibodies and placed into the V.sub.H1 and V.sub.H2 positions in the binding protein. Likewise, V.sub.L1 and V.sub.L2 could be derived from V.sub.H1 and V.sub.H2 domains in parent antibodies and placed in the V.sub.H1 and V.sub.H2 positions in the binding protein. Thus, the V.sub.H and V.sub.L designations refer to the present location and not the original location in a parent antibody. V.sub.H and V.sub.L domains are therefore swappable.

    [0335] The term antigen or target antigen or antigen target as used herein refers to a molecule or a portion of a molecule that is capable of being bound by a binding protein, and additionally is capable of being used in an animal to produce antibodies capable of binding to an epitope of that antigen. A target antigen may have one or more epitopes. With respect to each target antigen recognized by a binding protein, the binding protein is capable of competing with an intact antibody that recognizes the target antigen.

    [0336] The term HIV as used herein means Human Immunodeficiency Virus. As used herein, the term HIV infection generally encompasses infection of a host, particularly a human host, by the human immunodeficiency virus (HIV) family of retroviruses including, but not limited to, HIV I, HIV II, HIV III (also known as HTLV-II, LAV-1, LAV-2). HIV can be used herein to refer to any strains, forms, subtypes, clades and variations in the HIV family. Thus, treating HIV infection will encompass the treatment of a person who is a carrier of any of the HIV family of retroviruses or a person who is diagnosed with active AIDS, as well as the treatment or prophylaxis of the AIDS-related conditions in such persons.

    [0337] The term AIDS as used herein means Acquired Immunodeficiency Syndrome. AIDS is caused by HIV.

    [0338] The terms CD4bs or CD4 binding site refer to the binding site for CD4 (cluster of differentiation 4), which is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

    [0339] The term CD3 is cluster of differentiation factor 3 polypeptide and is a T-cell surface protein that is typically part of the T cell receptor (TCR) complex.

    [0340] CD28 is cluster of differentiation 28 polypeptide and is a T-cell surface protein that provides co-stimulatory signals for T-cell activation and survival.

    [0341] The term glycoprotein 160 or gp160 protein refers to the envelope glycoprotein complex of HIV and which is a homotrimer that is cleaved into gp120 and gp41 subunits.

    [0342] The term MPER refers to the membrane-proximal external region of glycoprotein 41 (gp41), which is a subunit of the envelope protein complex of retroviruses, including HIV.

    [0343] The term glycan refers to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan. In the disclosed binding proteins, glycan refers to the HIV-1 envelope glycoprotein gp120.

    [0344] The term T-cell engager refers to binding proteins directed to a host's immune system, more specifically the T cells' cytotoxic activity as well as directed to a HIV target protein.

    [0345] The term trimer apex refers to apex of HIV-1 envelope glycoprotein gp120.

    [0346] The term monospecific binding protein refers to a binding protein that specifically binds to one antigen target.

    [0347] The term monovalent binding protein refers to a binding protein that has one antigen binding site.

    [0348] The term bispecific binding protein refers to a binding protein that specifically binds to two different antigen targets.

    [0349] The term bivalent binding protein refers to a binding protein that has two binding sites.

    [0350] The term trispecific binding protein refers to a binding protein that specifically binds to three different antigen targets.

    [0351] The term trivalent binding protein refers to a binding protein that has three binding sites. In particular embodiments the trivalent binding protein can bind to one antigen target. In other embodiments, the trivalent binding protein can bind to two antigen targets. In other embodiments, the trivalent binding protein can bind to three antigen targets.

    [0352] An isolated binding protein is one that has been identified and separated and/or recovered from a component of its natural environment. Contaminant components of its natural environment are materials that would interfere with diagnostic or therapeutic uses for the binding protein, and may include enzymes, hormones, and other proteinaceous or non-proteinaceous solutes. In some embodiments, the binding protein will be purified: (1) to greater than 95% by weight of antibody as determined by the Lowry method, and most preferably more than 99% by weight, (2) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (3) to homogeneity by SDS-PAGE under reducing or nonreducing conditions using Coomassie blue or, preferably, silver stain. Isolated binding proteins include the binding protein in situ within recombinant cells since at least one component of the binding protein's natural environment will not be present.

    [0353] The terms substantially pure or substantially purified as used herein refer to a compound or species that is the predominant species present (i.e., on a molar basis it is more abundant than any other individual species in the composition). In some embodiments, a substantially purified fraction is a composition wherein the species comprises at least about 50% (on a molar basis) of all macromolecular species present. In other embodiments, a substantially pure composition will comprise more than about 80%, 85%, 90%, 95%, or 99% of all macromolar species present in the composition. In still other embodiments, the species is purified to essential homogeneity (contaminant species cannot be detected in the composition by conventional detection methods) wherein the composition consists essentially of a single macromolecular species.

    [0354] A neutralizing binding protein as used herein refers to a molecule that is able to block or substantially reduce an effector function of a target antigen to which it binds. As used herein, substantially reduce means at least about 60%, preferably at least about 70%, more preferably at least about 75%, even more preferably at least about 80%, still more preferably at least about 85%, most preferably at least about 90% reduction of an effector function of the target antigen.

    [0355] The term epitope includes any determinant, preferably a polypeptide determinant, capable of specifically binding to an immunoglobulin or T-cell receptor. In certain embodiments, epitope determinants include chemically active surface groupings of molecules such as amino acids, sugar side chains, phosphoryl groups, or sulfonyl groups, and, in certain embodiments, may have specific three-dimensional structural characteristics and/or specific charge characteristics. An epitope is a region of an antigen that is bound by an antibody or binding protein. In certain embodiments, a binding protein is said to specifically bind an antigen when it preferentially recognizes its target antigen in a complex mixture of proteins and/or macromolecules. In some embodiments, a binding protein is said to specifically bind an antigen when the equilibrium dissociation constant is 10.sup.8 M, more preferably when the equilibrium dissociation constant is 10.sup.9 M, and most preferably when the dissociation constant is 10.sup.10 M.

    [0356] The dissociation constant (K.sub.D) of a binding protein can be determined, for example, by surface plasmon resonance. Generally, surface plasmon resonance analysis measures real-time binding interactions between ligand (a target antigen on a biosensor matrix) and analyte (a binding protein in solution) by surface plasmon resonance (SPR) using the BIAcore system (Pharmacia Biosensor, Piscataway, NJ). Surface plasmon analysis can also be performed by immobilizing the analyte (binding protein on a biosensor matrix) and presenting the ligand (target antigen). The term K.sub.D, as used herein refers to the dissociation constant of the interaction between a particular binding protein and a target antigen.

    [0357] The term specifically binds as used herein refers to the ability of a binding protein or an antigen-binding fragment thereof to bind to an antigen containing an epitope with an Kd of at least about 110.sup.6 M, 110.sup.7M, 110.sup.8M, 110.sup.9M, 110.sup.10 M, 110.sup.11 M, 110.sup.12 M, or more, and/or to bind to an epitope with an affinity that is at least two-fold greater than its affinity for a nonspecific antigen.

    [0358] The term linker as used herein refers to one or more amino acid residues inserted between immunoglobulin domains to provide sufficient mobility for the domains of the light and heavy chains to fold into cross over dual variable region immunoglobulins. A linker is inserted at the transition between variable domains or between variable and constant domains, respectively, at the sequence level. The transition between domains can be identified because the approximate size of the immunoglobulin domains are well understood. The precise location of a domain transition can be determined by locating peptide stretches that do not form secondary structural elements such as beta-sheets or alpha-helices as demonstrated by experimental data or as can be assumed by techniques of modeling or secondary structure prediction. The linkers described herein are referred to as L.sub.1, which is located on the light chain between the C-terminus of the V.sub.L2 and the N-terminus of the V.sub.L1 domain; and L.sub.2, which is located on the light chain between the C-terminus of the V.sub.L1 and the N-terminus of the C.sub.L domain. The heavy chain linkers are known as L.sub.3, which is located between the C-terminus of the VHI and the N-terminus of the V.sub.H2 domain; and L4, which is located between the C-terminus of the V.sub.H2 and the N-terminus of the C.sub.H1 domain.

    [0359] The term vector as used herein refers to any molecule (e.g., nucleic acid, plasmid, or virus) that is used to transfer coding information to a host cell. The term vector includes a nucleic acid molecule that is capable of transporting another nucleic acid to which it has been linked. One type of vector is a plasmid, which refers to a circular double-stranded DNA molecule into which additional DNA segments may be inserted. Another type of vector is a viral vector, wherein additional DNA segments may be inserted into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) can be integrated into the genome of a host cell upon introduction into the host cell and thereby are replicated along with the host genome. In addition, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as recombinant expression vectors (or simply, expression vectors). In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. The terms plasmid and vector may be used interchangeably herein, as a plasmid is the most commonly used form of vector. However, the disclosure is intended to include other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses, and adeno-associated viruses), which serve equivalent functions.

    [0360] The phrase recombinant host cell (or host cell) as used herein refers to a cell into which a recombinant expression vector has been introduced. A recombinant host cell or host cell is intended to refer not only to the particular subject cell, but also to the progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but such cells are still included within the scope of the term host cell as used herein. A wide variety of host cell expression systems can be used to express the binding proteins, including bacterial, yeast, baculoviral, and mammalian expression systems (as well as phage display expression systems). An example of a suitable bacterial expression vector is pUC19. To express a binding protein recombinantly, a host cell is transformed or transfected with one or more recombinant expression vectors carrying DNA fragments encoding the polypeptide chains of the binding protein such that the polypeptide chains are expressed in the host cell and, preferably, secreted into the medium in which the host cells are cultured, from which medium the binding protein can be recovered.

    [0361] The term transformation as used herein refers to a change in a cell's genetic characteristics, and a cell has been transformed when it has been modified to contain a new DNA. For example, a cell is transformed where it is genetically modified from its native state. Following transformation, the transforming DNA may recombine with that of the cell by physically integrating into a chromosome of the cell, or may be maintained transiently as an episomal element without being replicated, or may replicate independently as a plasmid. A cell is considered to have been stably transformed when the DNA is replicated with the division of the cell. The term transfection as used herein refers to the uptake of foreign or exogenous DNA by a cell, and a cell has been transfected when the exogenous DNA has been introduced inside the cell membrane. A number of transfection techniques are well known in the art. Such techniques can be used to introduce one or more exogenous DNA molecules into suitable host cells.

    [0362] The term naturally occurring as used herein and applied to an object refers to the fact that the object can be found in nature and has not been manipulated by man. For example, a polynucleotide or polypeptide that is present in an organism (including viruses) that can be isolated from a source in nature and that has not been intentionally modified by man is naturally-occurring. Similarly, non-naturally occurring as used herein refers to an object that is not found in nature or that has been structurally modified or synthesized by man.

    [0363] As used herein, the twenty conventional amino acids and their abbreviations follow conventional usage. Stereoisomers (e.g., D-amino acids) of the twenty conventional amino acids; unnatural amino acids and analogs such as -,-disubstituted amino acids, N-alkyl amino acids, lactic acid, and other unconventional amino acids may also be suitable components for the polypeptide chains of the binding proteins. Examples of unconventional amino acids include: 4-hydroxyproline, -carboxyglutamate. -N,N,N-trimethyllysine, -N-acetyllysine, O-phosphoserine, N-acetylserine, N-formylmethionine, 3-methylhistidine, 5-hydroxylysine, -N-methylarginine, and other similar amino acids and imino acids (e.g., 4-hydroxyproline). In the polypeptide notation used herein, the left-hand direction is the amino terminal direction and the right-hand direction is the carboxyl-terminal direction, in accordance with standard usage and convention.

    [0364] Naturally occurring residues may be divided into classes based on common side chain properties: [0365] (1) hydrophobic: Met, Ala, Val, Leu, Ile, Phe, Trp, Tyr, Pro; [0366] (2) polar hydrophilic: Arg, Asn, Asp, Gln, Glu, His, Lys, Ser, Thr; [0367] (3) aliphatic: Ala, Gly, Ile, Leu, Val, Pro; [0368] (4) aliphatic hydrophobic: Ala, Ile, Leu, Val, Pro; [0369] (5) neutral hydrophilic: Cys, Ser, Thr, Asn, Gln; [0370] (6) acidic: Asp, Glu; [0371] (7) basic: His, Lys, Arg; [0372] (8) residues that influence chain orientation: Gly, Pro; [0373] (9) aromatic: His, Trp, Tyr, Phe; and [0374] (10) aromatic hydrophobic: Phe, Trp, Tyr.

    [0375] Conservative amino acid substitutions may involve exchange of a member of one of these classes with another member of the same class. Non-conservative substitutions may involve the exchange of a member of one of these classes for a member from another class.

    [0376] A skilled artisan will be able to determine suitable variants of the polypeptide chains of the binding proteins using well-known techniques. For example, one skilled in the art may identify suitable areas of a polypeptide chain that may be changed without destroying activity by targeting regions not believed to be important for activity. Alternatively, one skilled in the art can identify residues and portions of the molecules that are conserved among similar polypeptides. In addition, even areas that may be important for biological activity or for structure may be subject to conservative amino acid substitutions without destroying the biological activity or without adversely affecting the polypeptide structure.

    [0377] The term patient as used herein includes human and animal subjects.

    [0378] The terms treatment or treat as used herein refer to both therapeutic treatment and prophylactic or preventative measures. Those in need of treatment include those having the disorder as well as those prone to have a disorder or those in which the disorder is to be prevented. In particular embodiments, binding proteins can be used to treat humans infected with HIV, or humans susceptible to HIV infection, or ameliorate HIV infection in a human subject infected with HIV. The binding proteins can also be used to prevent HIV in a human patient.

    [0379] It should be understood as that treating humans infected with HIV include those subjects who are at any one of the several stages of HIV infection progression, which, for example, include acute primary infection syndrome (which can be asymptomatic or associated with an influenza-like illness with fevers, malaise, diarrhea and neurologic symptoms such as headache), asymptomatic infection (which is the long latent period with a gradual decline in the number of circulating CD4.sup.+T cells), and AIDS (which is defined by more serious AIDS-defining illnesses and/or a decline in the circulating CD4 cell count to below a level that is compatible with effective immune function). In addition, treating or preventing HIV infection will also encompass treating suspected infection by HIV after suspected past exposure to HIV by e.g., contact with HIV-contaminated blood, blood transfusion, exchange of body fluids, unsafe sex with an infected person, accidental needle stick, receiving a tattoo or acupuncture with contaminated instruments, or transmission of the virus from a mother to a baby during pregnancy, delivery or shortly thereafter.

    [0380] The terms pharmaceutical composition or therapeutic composition as used herein refer to a compound or composition capable of inducing a desired therapeutic effect when properly administered to a patient.

    [0381] The term pharmaceutically acceptable carrier or physiologically acceptable carrier as used herein refers to one or more formulation materials suitable for accomplishing or enhancing the delivery of a binding protein.

    [0382] The terms effective amount and therapeutically effective amount when used in reference to a pharmaceutical composition comprising one or more binding proteins refer to an amount or dosage sufficient to produce a desired therapeutic result. More specifically, a therapeutically effective amount is an amount of a binding protein sufficient to inhibit, for some period of time, one or more of the clinically defined pathological processes associated with the condition being treated. The effective amount may vary depending on the specific binding protein that is being used, and also depends on a variety of factors and conditions related to the patient being treated and the severity of the disorder. For example, if the binding protein is to be administered in vivo, factors such as the age, weight, and health of the patient as well as dose response curves and toxicity data obtained in preclinical animal work would be among those factors considered. The determination of an effective amount or therapeutically effective amount of a given pharmaceutical composition is well within the ability of those skilled in the art.

    [0383] One embodiment of the disclosure provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a binding protein.

    Trispecific and/or Trivalent Binding Proteins

    [0384] In one embodiment, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three different) HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00049## [0385] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00050## [0386] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00051## [0387] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00052## [0388] wherein: [0389] V.sub.L1 is a first immunoglobulin light chain variable domain; [0390] V.sub.L2 is a second immunoglobulin light chain variable domain; [0391] V.sub.L3 is a third immunoglobulin light chain variable domain; [0392] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0393] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0394] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0395] C.sub.L is an immunoglobulin light chain constant domain; [0396] C.sub.H1 is an immunoglobulin C.sub.H1 heavy chain constant domain; and [0397] L.sub.1, L.sub.2, L.sub.3 and L.sub.4 are amino acid linkers; [0398] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0399] In one embodiment, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three different) HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00053## [0400] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00054## [0401] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00055## [0402] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00056## [0403] wherein: [0404] V.sub.L1 is a first immunoglobulin light chain variable domain; [0405] V.sub.L2 is a second immunoglobulin light chain variable domain; [0406] V.sub.L3 is a third immunoglobulin light chain variable domain; [0407] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0408] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0409] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0410] C.sub.L is an immunoglobulin light chain constant domain; [0411] C.sub.H1 is an immunoglobulin C.sub.H1 heavy chain constant domain; [0412] C.sub.H2 is an immunoglobulin C.sub.H2 heavy chain constant domain; [0413] C.sub.H3 is an immunoglobulin C heavy chain constant domain; [0414] hinge is an immunoglobulin hinge region connecting the C.sub.H1 and C.sub.H2 domains, and [0415] L.sub.1, L.sub.2, L.sub.3 and L.sub.4 are amino acid linkers; [0416] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0417] In some embodiments, the first polypeptide chain and the second polypeptide chain have a cross-over orientation that forms two distinct antigen binding sites. In some embodiments, the V.sub.H1 and V.sub.L1 form a binding pair and form the first antigen binding site. In some embodiments, the V.sub.H2 and V.sub.H2 form a binding pair and form the second antigen binding site. In some embodiments, the third polypeptide and the fourth polypeptide form a third antigen binding site. In some embodiments, the V.sub.H3 and V.sub.L3 form a binding pair and form the third antigen binding site.

    [0418] In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210, 212, 218, 220, 226, 228, 233, 235, 241, 243; and V.sub.H1, V.sub.H2 and V.sub.H3, are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs:1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242. In other embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-283; and V.sub.H1, V.sub.H2 and V.sub.H3 each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a light chain variable domain comprising a light chain variable domain sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a heavy chain variable domain comprising a heavy chain variable domain sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a light chain variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a heavy chain variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein.

    [0419] In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; and V.sub.H1, V.sub.H2 and V.sub.H3, are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472. In other embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and V.sub.H1, V.sub.H2 and V.sub.H3 each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487.

    [0420] In particular embodiments, the order of the V.sub.H1 and V.sub.H2 domains, and therefore the order of V.sub.L1 and V.sub.L2 domains, in the polypeptide chain of formula I or the polypeptide chain of formula II (i.e., to reverse the order) are swapped.

    [0421] In some embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 4; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 3; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 1, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2.

    [0422] In some embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 12 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 12; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 11 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 1, the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 9 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 9; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 10 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 10.

    [0423] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 20 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 20; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 19; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 17 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 17; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 18 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 18.

    [0424] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 28 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 28; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 27 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 27; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 25 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 25; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 26 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 26.

    [0425] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 36, the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 35 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 35; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 33 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 33; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 34 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 34.

    [0426] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 44 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 44; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 43 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 43; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 41 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 41; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 42 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 42.

    [0427] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 52 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 52; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 51 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 51; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 49 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 49; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 50 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 50.

    [0428] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 60 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 60, the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 59 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 59; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 57 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 57; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 58 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 58.

    [0429] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 68 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 68; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 67 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 67; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 65 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 65; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 66 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 66.

    [0430] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 76 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 76; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 75 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 75; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 73 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 73; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 74 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 74.

    [0431] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 84 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 84, the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 83 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 83; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 81 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 81; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 82 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 82.

    [0432] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 92 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:92; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 91 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 91; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 89 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 89; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 90 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 90.

    [0433] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 100 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 100; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 99 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 99; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 97 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 97; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 98 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 98.

    [0434] In other embodiments, the first polypeptide comprises the amino acid sequence of SEQ ID NO: 108 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 108; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 107 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 107; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 105 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 105; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 106 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 106.

    [0435] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 116 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 116; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 115 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 115; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 113 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 113; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 114 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 114.

    [0436] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 124 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 124; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 123 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 123; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 121 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 121; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 122 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 122.

    [0437] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 132 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 132; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 131 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 131; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 129 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 129; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 130 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 130.

    [0438] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 140 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 140; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 139 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 139; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 137 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 137, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 138.

    [0439] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 148 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 148, the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 147 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 147; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 145 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 145; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 146 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 146.

    [0440] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 156 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 156; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 155 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 155; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 153 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 153; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 154 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 154.

    [0441] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 164 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 164; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 163 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 163; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 161 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 161, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 162 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 162.

    [0442] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 172 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 172, the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 171 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 171; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 169 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 169; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 170 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 170.

    [0443] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 180 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 180; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 179 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 179; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 177 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 177; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 178 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 178.

    [0444] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 188 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 188; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 187 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 187; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 185 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 185; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 186 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 186.

    [0445] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 196 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 196; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 195 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 195; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 193 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 193; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 194 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 194.

    [0446] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 204 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 204; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 203 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 203, the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 201 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 201; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 202 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 202.

    [0447] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 212 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 212; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 211 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 211; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 209 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 209; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 210 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 210.

    [0448] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 220 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 220; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 219 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 219; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 217 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 217; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 218 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 218.

    [0449] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 228 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 228; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 227 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 227, the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 225 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 225; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 226 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 226.

    [0450] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 235 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 235; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 234 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 234; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 232 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 232; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 233 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 233.

    [0451] In other embodiments, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 243 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 243; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 242 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 242; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 240 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 240; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 241 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 241.

    [0452] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 305 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 305; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 304 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 304; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 302 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 302, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 303 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 303.

    [0453] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 313 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 313; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 312 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 312; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 310 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 310, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 311 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 311.

    [0454] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 321 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 321; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 320 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 320; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 318 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 318; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 319 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 319.

    [0455] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 329 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 329; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 328 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 328; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 326 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 326; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 327 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 327.

    [0456] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 337 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 337; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 336 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 336; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 334 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 334; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 335 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 335.

    [0457] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 345 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 345; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 344 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 344; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 342 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 342; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 343 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 343.

    [0458] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 353 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 353; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 352 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:352; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 350 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 350; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 351 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 351.

    [0459] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 361 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 361; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 360 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 360; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 358 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 358; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 359 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 359.

    [0460] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 369 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 369; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 368 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 368; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 366 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 366; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 367 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 367.

    [0461] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 377 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 377; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 376 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 376; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 374 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 374; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 375 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 375.

    [0462] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 385 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 385; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 384 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 384; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 382 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 382; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 383 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 383.

    [0463] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 393 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 393; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 392 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 392; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 390 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 390; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 391 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 391.

    [0464] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 401 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 401; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 400 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 400; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 398 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 398; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 399 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 399.

    [0465] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 409 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 409; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 408 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 408; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 406 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 406; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 407 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 407.

    [0466] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 417 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 417; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 416 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 416; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 414 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 414; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 415 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 415.

    [0467] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 425 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 425; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 424 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 424; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 422 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 422, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 423 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 423.

    [0468] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 433 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:433; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 432 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 432; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 430 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 430, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 431 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 431.

    [0469] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 441 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 441, the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 440 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 440; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 438 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 438; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 439 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 439.

    [0470] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 449 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 449; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 448 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 448; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 446 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 446; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 447 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 447.

    [0471] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 457 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 457; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 456 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 456; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 454 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 454; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 455 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 455.

    [0472] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 465 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 465; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 464 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 464; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 462 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 462; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 463 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 463.

    [0473] In another embodiment, the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 473 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 473; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 472 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 472; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 470 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 470; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 471 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 471.

    [0474] In other embodiments, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three) HIV target antigens, wherein a first polypeptide chain has a structure represented by the formula:

    ##STR00057## [0475] and a second polypeptide chain has a structure represented by the formula:

    ##STR00058## [0476] and a third polypeptide chain has a structure represented by the formula:

    ##STR00059## [0477] and a fourth polypeptide chain has a structure represented by the formula:

    ##STR00060## [0478] wherein: [0479] V.sub.L1 is a first immunoglobulin light chain variable domain; [0480] V.sub.L2 is a second immunoglobulin light chain variable domain; [0481] V.sub.L3 is a third immunoglobulin light chain variable domain; [0482] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0483] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0484] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0485] C.sub.L is an immunoglobulin light chain constant domain; [0486] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; and [0487] L.sub.1, L.sub.2, L.sub.3 and L4 are amino acid linkers; [0488] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0489] In other embodiments, the binding protein of the disclosure is a trispecific and/or trivalent binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., three) HIV target antigens, wherein a first polypeptide chain has a structure represented by the formula:

    ##STR00061## [0490] and a second polypeptide chain has a structure represented by the formula:

    ##STR00062## [0491] and a third polypeptide chain has a structure represented by the formula:

    ##STR00063## [0492] and a fourth polypeptide chain has a structure represented by the formula:

    ##STR00064## [0493] wherein: [0494] V.sub.L1 is a first immunoglobulin light chain variable domain; [0495] V.sub.L2 is a second immunoglobulin light chain variable domain; [0496] V.sub.L3 is a third immunoglobulin light chain variable domain; [0497] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0498] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0499] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0500] C.sub.L is an immunoglobulin light chain constant domain; [0501] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; and [0502] L.sub.1, L.sub.2, L.sub.3 and L.sub.4 are amino acid linkers; [0503] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    Additional Examples of Trispecific Binding Proteins

    [0504] In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521.

    [0505] In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508.

    [0506] In some embodiments, V.sub.L1, V.sub.L2, and V.sub.L3 comprise an amino acid sequence as set forth in SEQ ID NOs: 518, 519, and 512, respectively, and V.sub.H1, V.sub.H2, and V.sub.H3 comprise an amino acid sequence as set forth in SEQ ID NOs: 504, 506, and 502, respectively. In some embodiments, V.sub.L1, V.sub.L2, and V.sub.L3 comprise an amino acid sequence as set forth in SEQ ID NOs: 518, 519, and 513, respectively, and V.sub.H1, V.sub.H2, and V.sub.H3 comprises an amino acid sequence as set forth in SEQ ID NOs: 504, 506, and 503, respectively. In some embodiments, V.sub.L1, V.sub.L2, and V.sub.L3 comprises an amino acid sequence as set forth in SEQ ID NOs: 519, 518, and 513, respectively, and V.sub.H1, V.sub.H2, and V.sub.H3 comprises an amino acid sequence as set forth in SEQ ID NOs: 506, 504, and 503, respectively.

    [0507] In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising a CDR-LL, CDR-L2, and CDR-L3 of a light chain variable domain comprising a light chain variable domain sequence shown in Table C. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a heavy chain variable domain sequence shown in Table C.

    [0508] In some embodiments, V.sub.L1 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 518, V.sub.L2 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 519, V.sub.L3 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 512, V.sub.H1 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 504, V.sub.H2 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 506, and V.sub.H3 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 502. In some embodiments, V.sub.L1 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 518. V.sub.L2 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 519, V.sub.L3 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 513. V.sub.H1 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 504, V.sub.H2 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 506, and V.sub.H3 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503. In some embodiments, V.sub.L1 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 519, V.sub.L2 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 518, V.sub.L3 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 513, and VHI is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 506, V.sub.H2 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 504, and V.sub.H3 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503.

    [0509] In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising: (a) a CDR-L1 comprising a sequence selected from the group consisting of SEQ ID NOs: 266, 269, 275, 278, 281, and 500; (b) a CDR-L2 comprising a sequence selected from the group consisting of SEQ ID NO:267, GKN, ETD, NNQ, LAS, and HTS; and/or (c) a CDR-L3 comprising a sequence selected from the group consisting of SEQ ID NOs: 268, 271, 274, 277, 280, and 283. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising amino acid sequences as shown in Table B. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; or a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively.

    [0510] In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising: (a) a CDR-H1 comprising a sequence selected from the group consisting of SEQ ID NOs: 248, 251, 254, 257, 263, and 499; (b) a CDR-H2 comprising a sequence selected from the group consisting of SEQ ID NOs: 252, 255, 258, 261, 264, and 497, and/or (c) a CDR-H3 comprising a sequence selected from the group consisting of SEQ ID NOs: 250, 253, 256, 259, 262, 265, and 498. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising amino acid sequences as shown in Table B. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively.

    [0511] In some embodiments, V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NOs: 266, 267, and 268, respectively; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 254, 255, and 256, respectively; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 257, 258, and 259, respectively; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 248, 497, and 250, respectively. In some embodiments, V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID N0:500, GKN, and SEQ ID NO:274, respectively; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 254, 255, and 256, respectively; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 257, 258, and 259, respectively; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively. In some embodiments, V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; V.sub.L3 comprises a CDR-L1, CDR-L.sub.2, and CDR-L3 comprising the sequence of SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 257, 258, and 259, respectively; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 254, 255, and 256, respectively; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively.

    Additional Trispecific Binding Proteins Targeting One or More HIV Target Proteins and One or More T Cell Target Proteins

    [0512] in some embodiments, a binding protein of the present disclosure comprises four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., one or two) HIV target proteins and one or more (e.g., one or two) T cell target proteins, wherein a first polypeptide chain has a structure represented by the formula:

    ##STR00065## [0513] a second polypeptide chain has a structure represented by the formula:

    ##STR00066## [0514] a third polypeptide chain has a structure represented by the formula:

    ##STR00067## [0515] and a fourth polypeptide chain has a structure represented by the formula:

    ##STR00068## [0516] wherein [0517] V.sub.L1 is a first immunoglobulin light chain variable domain; [0518] V.sub.L2 is a second immunoglobulin light chain variable domain; [0519] V.sub.L3 is a third immunoglobulin light chain variable domain; [0520] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0521] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0522] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0523] C.sub.L is an immunoglobulin light chain constant domain; [0524] C.sub.H1 is an immunoglobulin C.sub.H1 heavy chain constant domain; and [0525] L.sub.1, L.sub.2, L3, and L.sub.4 are amino acid linkers; [0526] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0527] In some embodiments, a binding protein of the present disclosure comprises four polypeptide chains that form three antigen binding sites that specifically bind one or more (e.g., one or two) HIV target proteins and one or more (e.g., one or two) T cell target proteins, wherein a first polypeptide chain has a structure represented by the formula:

    ##STR00069## [0528] a second polypeptide chain has a structure represented by the formula:

    ##STR00070## [0529] a third polypeptide chain has a structure represented by the formula:

    ##STR00071## [0530] and a fourth polypeptide chain has a structure represented by the formula

    ##STR00072## [0531] wherein [0532] V.sub.L1 is a first immunoglobulin light chain variable domain; [0533] V.sub.L2 is a second immunoglobulin light chain variable domain; [0534] V.sub.L3 is a third immunoglobulin light chain variable domain; [0535] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0536] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0537] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0538] C.sub.L is an immunoglobulin light chain constant domain; [0539] C.sub.H1 is an immunoglobulin C.sub.H1 heavy chain constant domain; [0540] C.sub.H2 is an immunoglobulin C.sub.H2 heavy chain constant domain; [0541] C.sub.H3 is an immunoglobulin C.sub.H3 heavy chain constant domain; [0542] hinge is an immunoglobulin hinge region connecting the C.sub.H1 and C.sub.H2 domains; and [0543] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers; [0544] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0545] In some embodiments, the first polypeptide chain and the second polypeptide chain have a cross-over orientation that forms two distinct antigen binding sites. In some embodiments, the V.sub.H1 and V.sub.L1 form a binding pair and form the first antigen binding site. In some embodiments, the V.sub.H2 and V.sub.L2 form a binding pair and form the second antigen binding site. In some embodiments, the third polypeptide and the fourth polypeptide form a third antigen binding site. In some embodiments, the V.sub.H3 and V.sub.L3 form a binding pair and form the third antigen binding site.

    [0546] In some embodiments, VU, Vu and V are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0547] In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising an amino acid sequence having at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% sequence identity to a sequence as set forth in any one of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0548] In some embodiments, V.sub.L1, V.sub.L2, and V.sub.L3 comprise an amino acid sequence as set forth in SEQ ID NOs: 522, 524, and 513, respectively, and V.sub.H1, V.sub.H2, and V.sub.H3 comprise an amino acid sequence as set forth in SEQ ID NOs: 509, 511, and 503, respectively. In some embodiments, V.sub.L1, V.sub.L2, and V.sub.L3 comprise an amino acid sequence as set forth in SEQ ID NOs: 524, 522, and 513, respectively, and V.sub.H1, V.sub.H2, and V.sub.H3 comprise an amino acid sequence as set forth in SEQ ID NOs: 511,509, and 503, respectively.

    [0549] In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0550] In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0551] In some embodiments, V.sub.L1 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 522, V.sub.L2 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 524, V.sub.L3 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 513, V.sub.H1 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 509, V.sub.H2 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 511, and V.sub.H3 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503. In some embodiments, V.sub.L1 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 524, V.sub.L2 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence of SEQ ID NO: 522, V.sub.L3 is a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a light chain variable domain sequence of SEQ ID NO: 513, V.sub.H1 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 511, V.sub.H2 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 509, and V.sub.H3 is a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence of SEQ ID NO: 503.

    [0552] In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising: (a) a CDR-L1 comprising a sequence selected from the group consisting of SEQ ID NOs: 266, 269, 275, 278, 281, 488, 491, 494 and 500; (b) a CDR-L2 comprising a sequence selected from the group consisting of SEQ ID NO: 267, GKN, KVS, AAS, KAS, ETD, NNQ, LAS, and HTS; and (c) a CDR-L3 comprising a sequence selected from the group consisting of SEQ ID NOs: 268, 271, 274, 277, 280, 283, 490, 493, and 496. In some embodiments. V.sub.L1, V.sub.L3 and V.sub.L3 are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising amino acid sequences as shown in Table B. In some embodiments, V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain comprising a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500. GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively; a sequence as set forth in SEQ ID NO:488, KAS, and SEQ ID NO:490, respectively; a sequence as set forth in SEQ ID NO:491, AAS, and SEQ ID NO:493, respectively, or a sequence as set forth in SEQ ID NO:494, KVS, and SEQ ID NO:4%, respectively.

    [0553] In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising: (a) a CDR-H1 comprising a sequence selected from the group consisting of SEQ ID NOs: 248, 251, 254, 257, 263, 479, 482, 485, and 499; (b) a CDR-H2 comprising a sequence selected from the group consisting of SEQ ID NOs: 252, 255, 258, 261, 264, 480, 483, 486, and 497; and (c) a CDR-H3 comprising a sequence selected from the group consisting of SEQ ID NOs: 250, 253, 256, 259, 262, 265, 481, 484, 487, and 498. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising amino acid sequences as shown in Table B. In some embodiments, V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain comprising a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively, a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively.

    [0554] In some embodiments, V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:488, KAS, and SEQ ID NO:490, respectively; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:494, KVS, and SEQ ID NO:496, respectively; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 479, 480, and 481, respectively; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 485, 486, and 487, respectively; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively. In some embodiments, V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:494, KVS, and SEQ ID NO:496, respectively; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:488, KAS, and SEQ ID NO:490, respectively; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising the sequence of SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 485, 486, and 487, respectively; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 479, 480, and 481, respectively; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising the sequence of SEQ ID NOs: 251, 252, and 253, respectively.

    [0555] In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein. In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein.

    [0556] In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS a. CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein. In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein.

    [0557] In some embodiments, Vu. and VHI are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein. In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a. V1/V2 directed b, or V3 directed described herein.

    [0558] In some embodiments, Vu. and V.sub.H1 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein. In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein.

    [0559] In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein. In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising the six CDRs of antibody CD3 described herein.

    [0560] In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD4BS a, CD4BS b, MPER, MPER 100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD3 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising a light and heavy chain variable sequence of antibody CD28 or CD28_2 described herein. In some embodiments, V.sub.L1 and V.sub.H1 are light and heavy chain variable domains comprising the six CDRs of antibody CD4BS a, CD4BS b, MPER, MPER_100W, V1/V2 directed a, V1/V2 directed b, or V3 directed described herein, V.sub.L2 and V.sub.H2 are light and heavy chain variable domains comprising the six CDRs of antibody CD3 or CD28_2 described herein, and V.sub.L3 and V.sub.H3 are light and heavy chain variable domains comprising the six CDRs of antibody CD28 or CD28_2 described herein.

    Target Proteins

    [0561] In one embodiment, the binding proteins specifically bind to one or more HIV target proteins. In some embodiments, the binding proteins are trispecific and specifically bind to MPER of the HIV-1 gp41 protein, a CD4 binding site of the HIV-1 gp120 protein, a glycan in the V3 loop of the HIV-1 gp120 protein, a trimer apex of the HIV-1 gp120 protein or gp160. In other embodiments, the binding proteins specifically bind to one or more HIV target proteins and one or more target proteins on a T-cell including T cell receptor complex. These T-cell engager binding proteins are capable of recruiting T cells transiently to target cells and, at the same time, activating the cytolytic activity of the T cells. The T-cell engager trispecific antibodies can be used to activate HIV-1 reservoirs and redirect/activate T cells to lyse latently infected HIV-1 T cells. Examples of target proteins on T cells include but are not limited to CD3 and CD28, among others. In some embodiments, the trispecific binding proteins may be generated by combining the antigen binding domains of two or more monospecific antibodies (parent antibodies) into one antibody. See International Publication Nos. WO 2011/038290 A2, WO 2013/086533 A1, WO 2013/070776 A1, WO 2012/154312 A1, and WO 2013/163427 A1, which are hereby incorporated into this disclosure by reference. The binding proteins of the disclosure may be prepared using domains or sequences obtained or derived from any human or non-human antibody, including, for example, human, murine, or humanized antibodies.

    [0562] In some embodiments of the disclosure, the trivalent binding protein is capable of binding three different antigen targets. In one embodiment, the binding protein is trispecific and one light chain-heavy chain pair is capable of binding two different antigen targets or epitopes and one light chain-heavy chain pair is capable of binding one antigen target or epitope. In another embodiment, the binding protein is capable of binding three different HIV antigen targets that are located on the HIV envelope glycoprotein structure composed of gp120 and gp41 subunits. In other embodiments, the binding protein is capable of inhibiting the function of one or more of the antigen targets.

    [0563] In some embodiments, a binding protein of the present disclosure binds one or more HIV target proteins. In some embodiments, the binding protein is capable of specifically binding three different epitopes on a single HIV target protein. In some embodiments, the binding protein is capable of binding two different epitopes on a first HIV target protein, and one epitope on a second HIV target protein. In some embodiments, the first and second HIV target proteins are different. In some embodiments, the binding protein is capable of specifically binding three different HIV target protein. In some embodiments, the one or more HIV target proteins are one or more of glycoprotein 120, glycoprotein 41, and glycoprotein 160.

    [0564] In some embodiments, a binding protein of the present disclosure binds one or more HIV target proteins and one or more T cell target proteins. In some embodiments, the binding protein is capable of specifically binding one HIV target protein and two different epitopes on a single T cell target protein. In some embodiments, the binding protein is capable of specifically binding one HIV target protein and two different T cell target proteins (e.g., CD28 and CD3). In some embodiments, the binding protein is capable of specifically binding one T cell target protein and two different epitopes on a single HIV target protein. In some embodiments, the binding protein is capable of specifically binding one T cell target protein and two different HIV target proteins. In some embodiments, the first and second polypeptide chains of the binding protein form two antigen binding sites that specifically target two T cell target proteins, and the third and fourth polypeptide chains of the binding protein form an antigen binding site that specifically binds an HIV target protein. In some embodiments, the one or more HIV target proteins are one or more of glycoprotein 120, glycoprotein 41, and glycoprotein 160. In some embodiments, the one or more T cell target proteins are one or more of CD3 and CD28.

    Linkers

    [0565] In some embodiments, the linkers L.sub.1, L.sub.2, L.sub.3, and L.sub.4 range from no amino acids (length=0) to about 100 amino acids long, or less than 100, 50, 40, 30, 20, or 15 amino acids or less. The linkers can also be 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 amino acids long. L.sub.1, L.sub.2, L.sub.3, and L.sub.4 in one binding protein may all have the same amino acid sequence or may all have different amino acid sequences.

    [0566] Examples of suitable linkers include a single glycine (Gly) residue; a diglycine peptide (Gly-Gly); a tripeptide (Gly-Gly-Gly); a peptide with four glycine residues (Gly-Gly-Gly-Gly; SEQ ID NO: 285); a peptide with five glycine residues (Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 286); a peptide with six glycine residues (Gly-Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 287); a peptide with seven glycine residues (Gly-Gly-Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 288); a peptide with eight glycine residues (Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly; SEQ ID NO: 289). Other combinations of amino acid residues may be used such as the peptide Gly-Gly-Gly-Gly-Ser (SEQ ID NO: 290), the peptide Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser (SEQ ID NO: 291) and the peptide Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser-Gly-Gly-Gly-Gly-Ser (SEQ ID NO: 292). Other suitable linkers include a single Ser, and Val residue; the dipeptide Arg-Thr, Gln-Pro, Ser-Ser, Thr-Lys, and Ser-Leu; Thr-Lys-Gly-Pro-Ser (SEQ ID NO: 293), Thr-Val-Ala-Ala-Pro (SEQ ID NO: 294), Gln-Pro-Lys-Ala-Ala (SEQ ID NO: 295), Gln-Arg-Ile-Glu-Gly (SEQ ID NO: 296); Ala-Ser-Thr-Lys-Gly-Pro-Ser (SEQ ID NO: 297), Arg-Thr-Val-Ala-Ala-Pro-Ser (SEQ ID NO: 298), Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299), and His-Ile-Asp-Ser-Pro-Asn-Lys (SEQ ID NO: 300). The examples listed above are not intended to limit the scope of the disclosure in any way, and linkers comprising randomly selected amino acids selected from the group consisting of valine, leucine, isoleucine, serine, threonine, lysine, arginine, histidine, aspartate, glutamate, asparagine, glutamine, glycine, and proline have been shown to be suitable in the binding proteins.

    [0567] The identity and sequence of amino acid residues in the linker may vary depending on the type of secondary structural element necessary to achieve in the linker. For example, glycine, serine, and alanine are best for linkers having maximum flexibility. Some combination of glycine, proline, threonine, and serine are useful if a more rigid and extended linker is necessary. Any amino acid residue may be considered as a linker in combination with other amino acid residues to construct larger peptide linkers as necessary depending on the desired properties.

    [0568] In some embodiments, the length of L.sub.1 is at least twice the length of L.sub.3. In some embodiments, the length of L.sub.2 is at least twice the length of L.sub.4. In some embodiments, the length of L.sub.1 is at least twice the length of L.sub.3, and the length of L.sub.2 is at least twice the length of L4. In some embodiments, L.sub.1 is 3 to 12 amino acid residues in length, L.sub.2 is 3 to 14 amino acid residues in length, L.sub.3 is 1 to 8 amino acid residues in length, and L.sub.4 is 1 to 3 amino acid residues in length. In some embodiments, L.sub.1 is 5 to 10 amino acid residues in length, L.sub.2 is 5 to 8 amino acid residues in length, L.sub.3 is 1 to 5 amino acid residues in length, and L.sub.4 is 1 to 2 amino acid residues in length. In some embodiments, L.sub.1 is 7 amino acid residues in length, L.sub.2 is 5 amino acid residues in length. L.sub.3 is 1 amino acid residue in length, and L.sub.4 is 2 amino acid residues in length.

    [0569] In some embodiments, L.sub.1, L.sub.2, L.sub.3, and/or L.sub.4 comprise the sequence Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). In some embodiments, L.sub.1 comprises the sequence Asp-Lys-Thr-His-Thr (SEQ ID NO: 525). In some embodiments, L.sub.3 comprises the sequence Asp-Lys-Thr-His-Thr (SEQ ID NO: 525).

    [0570] In some embodiments, L.sub.1, L.sub.2, L.sub.3, and/or L.sub.4 comprise the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). In some embodiments, L.sub.1 comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). In some embodiments, L.sub.1 comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299), L.sub.2 comprises the sequence Thr-Lys-Gly-Pro-Ser-Arg (SEQ ID NO: 526), L.sub.3 comprises the sequence Ser, and La comprises the sequence Arg-Thr. In some embodiments, L.sub.3 comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299). In some embodiments, L.sub.1 comprises the sequence Ser, L.sub.2 comprises the sequence Arg-Thr. L.sub.3 comprises the sequence Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299) and L.sub.4 comprises the sequence Thr-Lys-Gly-Pro-Ser-Arg (SEQ ID NO: 526).

    Fc Regions and Constant Domains

    [0571] In some embodiments, a binding protein of the present disclosure comprises a second polypeptide chain further comprising an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains. In some embodiments, a binding protein of the present disclosure comprises a third polypeptide chain further comprising an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains. In some embodiments, a binding protein of the present disclosure comprises a second polypeptide chain further comprising an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, and a third polypeptide chain further comprising an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0572] To improve the yields of the binding proteins, in some embodiments, the C.sub.H3 domains can be altered by the knob-into-holes technology which is described in detail with several examples in, for example, International Publication No. WO 96/027011, Ridgway et al., 1996, Protein Eng. 9: 617-21; and Merchant et al., 1998, Nat. Biotechnol. 16: 677-81. Specifically, the interaction surfaces of the two C.sub.H3 domains are altered to increase the heterodimerisation of both heavy chains containing these two Cat domains. Each of the two C.sub.H3 domains (of the two heavy chains) can be the knob, while the other is the hole. The introduction of a disulfide bridge further stabilizes the heterodimers (Merchant et al., 1998; Atwell et al., 1997, J. Mol. Biol. 270: 26-35) and increases the yield. In particular embodiments, the knob is on the second pair of polypeptides with a single variable domain. In other embodiments, the knob is on the first pair of polypeptides having the cross-over orientation. In yet other embodiments, the C.sub.H3 domains do not include a knob in hole.

    [0573] In some embodiments, a binding protein of the present disclosure comprises a knob mutation on the second polypeptide chain and a hole mutation on the third polypeptide chain. In some embodiments, a binding protein of the present disclosure comprises a knob mutation on the third polypeptide chain and a hole mutation on the second polypeptide chain. In some embodiments, the knob mutation comprises substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index. In some embodiments, the amino acid substitutions are S354C and T366W. In some embodiments, the hole mutation comprises substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index. In some embodiments, the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V. In some embodiments, the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0574] In some embodiments, a binding protein of the present disclosure comprises one or more mutations to improve serum half-life (See e.g., Hinton, P. R. et al. (2006) J. Immunol. 176(1):346-56). In some embodiments, the mutation comprises substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. In some embodiments, the binding protein comprises a second polypeptide chain further comprising a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, and a third polypeptide chain further comprising a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S. In some embodiments, a binding protein of the present disclosure comprises knob and hole mutations and one or more mutations to improve serum half-life.

    [0575] In some embodiments, C.sub.H1, C.sub.H2, C.sub.H3 and C.sub.L of the trispecific binding proteins described herein may comprise any of C.sub.H1, C.sub.H2, C.sub.H3 and C.sub.L sequences of binding proteins 1-53.

    Nucleic Acids

    [0576] Standard recombinant DNA methodologies are used to construct the polynucleotides that encode the polypeptides which form the binding proteins, incorporate these polynucleotides into recombinant expression vectors, and introduce such vectors into host cells. See e.g., Sambrook et al., 2001, MOLECULAR CLONING: A LABORATORY MANUAL (Cold Spring Harbor Laboratory Press, 3rd ed.). Enzymatic reactions and purification techniques may be performed according to manufacturer's specifications, as commonly accomplished in the art, or as described herein. Unless specific definitions are provided, the nomenclature utilized in connection with, and the laboratory procedures and techniques of, analytical chemistry, synthetic organic chemistry, and medicinal and pharmaceutical chemistry described herein are those well-known and commonly used in the art. Similarly, conventional techniques may be used for chemical syntheses, chemical analyses, pharmaceutical preparation, formulation, delivery, and treatment of patients.

    [0577] Other aspects of the present disclosure relate to isolated nucleic acid molecules comprising a nucleotide sequence encoding any of the binding proteins described herein. In some embodiments, the isolated nucleic acid is operably linked to a heterologous promoter to direct transcription of the binding protein-coding nucleic acid sequence. A promoter may refer to nucleic acid control sequences which direct transcription of a nucleic acid. A first nucleic acid sequence is operably linked to a second nucleic acid sequence when the first nucleic acid sequence is placed in a functional relationship with the second nucleic acid sequence. For instance, a promoter is operably linked to a coding sequence of a binding protein if the promoter affects the transcription or expression of the coding sequence. Examples of promoters may include, but are not limited to, promoters obtained from the genomes of viruses (such as polyoma virus, fowlpox virus, adenovirus (such as Adenovirus 2), bovine papilloma virus, avian sarcoma virus, cytomegalovirus, a retrovirus, hepatitis-B virus, Simian Virus 40 (SV40), and the like), from heterologous eukaryotic promoters (such as the actin promoter, an immunoglobulin promoter, from heat-shock promoters, and the like), the CAG-promoter (Niwa et al., Gene 108(2):193-9, 1991), the phosphoglycerate kinase (PGK)-promoter, a tetracycline-inducible promoter (Masui et al., Nucleic Acids Res. 33:e43, 2005), the lac system, the trp system, the tac system, the trc system, major operator and promoter regions of phage lambda, the promoter for 3-phosphoglycerate kinase, the promoters of yeast acid phosphatase, and the promoter of the yeast alpha-mating factors. Polynucleotides encoding binding proteins of the present disclosure may be under the control of a constitutive promoter, an inducible promoter, or any other suitable promoter described herein or other suitable promoter that will be readily recognized by one skilled in the art.

    [0578] In some embodiments, the isolated nucleic acid is incorporated into a vector. In some embodiments, the vector is an expression vector. Expression vectors may include one or more regulatory sequences operatively linked to the polynucleotide to be expressed. The term regulatory sequence includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Examples of suitable enhancers may include, but are not limited to, enhancer sequences from mammalian genes (such as globin, elastase, albumin. -fetoprotein, insulin and the like), and enhancer sequences from a eukaryotic cell virus (such as SV40 enhancer on the late side of the replication origin (bp 100-270), the cytomegalovirus early promoter enhancer, the polyoma enhancer on the late side of the replication origin, adenovirus enhancers, and the like). Examples of suitable vectors may include, for example, plasmids, cosmids, episomes, transposons, and viral vectors (e.g., adenoviral, vaccinia viral, Sindbis-viral, measles, herpes viral, lentiviral, retroviral, adeno-associated viral vectors, etc.). Expression vectors can be used to transfect host cells, such as, for example, bacterial cells, yeast cells, insect cells, and mammalian cells. Biologically functional viral and plasmid DNA vectors capable of expression and replication in a host are known in the art, and can be used to transfect any cell of interest.

    [0579] Other aspects of the present disclosure relate to a vector system comprising one or more vectors encoding a first, second, third, and fourth polypeptide chain of any of the binding proteins described herein. In some embodiments, the vector system comprises a first vector encoding the first polypeptide chain of the binding protein, a second vector encoding the second polypeptide chain of the binding protein, a third vector encoding the third polypeptide chain of the binding protein, and a fourth vector encoding the fourth polypeptide chain of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first and second polypeptide chains of the binding protein, and a second vector encoding the third and fourth polypeptide chains of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first and third polypeptide chains of the binding protein, and a second vector encoding the second and fourth polypeptide chains of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first and fourth polypeptide chains of the binding protein, and a second vector encoding the second and third polypeptide chains of the binding protein. In some embodiments, the vector system comprises a first vector encoding the first, second, third, and fourth polypeptide chains of the binding protein. The one or more vectors of the vector system may be any of the vectors described herein. In some embodiments, the one or more vectors are expression vectors.

    Host Cells

    [0580] Other aspects of the present disclosure relate to a host cell (e.g., an isolated host cell) comprising one or more isolated polynucleotides, vectors, and/or vector systems described herein. In some embodiments, an isolated host cell of the present disclosure is cultured in vitro. In some embodiments, the host cell is a bacterial cell (e.g., an E. coli cell). In some embodiments, the host cell is a yeast cell (e.g., an S. cerevisiae cell). In some embodiments, the host cell is an insect cell. Examples of insect host cells may include, for example, Drosophila cells (e.g., S2 cells), Trichoplusia ni cells (e.g., High Five cells), and Spodoptera frugiperda cells (e.g., Sf21 or Sf9 cells). In some embodiments, the host cell is a mammalian cell. Examples of mammalian host cells may include, for example, human embryonic kidney cells (e.g., 293 or 293 cells subcloned for growth in suspension culture), Expi293 cells, CHO cells, baby hamster kidney cells (e.g., BHK, ATCC CCL 10), mouse sertoli cells (e.g., TM4 cells), monkey kidney cells (e.g., CVI ATCC CCL 70), African green monkey kidney cells (e.g., VERO-76, ATCC CRL-1587), human cervical carcinoma cells (e.g., HELA, ATCC CCL 2), canine kidney cells (e.g., MDCK, ATCC CCL 34), buffalo rat liver cells (e.g., BRL 3A, ATCC CRL 1442), human lung cells (e.g., W138, ATCC CCL 75), human liver cells (e.g., Hep G2, HB 8065), mouse mammary tumor cells (e.g., MMT 060562, ATCC CCL51), TRI cells, MRC 5 cells, FS4 cells, a human hepatoma line (e.g., Hep G2), and myeloma cells (e.g., NS0 and Sp2/0 cells).

    [0581] Other aspects of the present disclosure relate to a method of producing any of the binding proteins described herein. In some embodiments, the method includes a) culturing a host cell (e.g., any of the host cells described herein) comprising an isolated nucleic acid, vector, and/or vector system (e.g., any of the isolated nucleic acids, vectors, and/or vector systems described herein) under conditions such that the host cell expresses the binding protein, and b) isolating the binding protein from the host cell. Methods of culturing host cells under conditions to express a protein are well known to one of ordinary skill in the art. Methods of isolating proteins from cultured host cells are well known to one of ordinary skill in the art, including, for example, by affinity chromatography (e.g., two step affinity chromatography comprising protein A affinity chromatography followed by size exclusion chromatography).

    Use for Binding Proteins

    [0582] The binding proteins can be employed in any known assay method, such as competitive binding assays, direct and indirect sandwich assays, and immunoprecipitation assays for the detection and quantitation of one or more target antigens. The binding proteins will bind the one or more target antigens with an affinity that is appropriate for the assay method being employed.

    [0583] For diagnostic applications, in certain embodiments, binding proteins can be labeled with a detectable moiety. The detectable moiety can be any one that is capable of producing, either directly or indirectly, a detectable signal. For example, the detectable moiety can be a radioisotope, such as .sup.3H, .sup.14C, .sup.33P, .sup.35S, .sup.125I, .sup.99Tc, .sup.111In, or .sup.67Ga; a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin; or an enzyme, such as alkaline phosphatase, -galactosidase, or horseradish peroxidase.

    [0584] The binding proteins are also useful for in vivo imaging. A binding protein labeled with a detectable moiety can be administered to an animal, e.g., into the bloodstream, and the presence and location of the labeled antibody in the host assayed. The binding protein can be labeled with any moiety that is detectable in an animal, whether by nuclear magnetic resonance, radiology, or other detection means known in the art.

    [0585] The disclosure also relates to a kit comprising a binding protein and other reagents useful for detecting target antigen levels in biological samples. Such reagents can include a detectable label, blocking serum, positive and negative control samples, and detection reagents. In some embodiments, the kit comprises a composition comprising any binding protein, polynucleotide, vector, vector system, and/or host cell described herein. In some embodiments, the kit comprises a container and a label or package insert on or associated with the container. Suitable containers include, for example, bottles, vials, syringes, IV solution bags, etc. The containers may be formed from a variety of materials such as glass or plastic. The container holds a composition which is by itself or combined with another composition effective for treating, preventing and/or diagnosing a condition (e.g., HIV infection) and may have a sterile access port (for example the container may be an intravenous solution bag or a vial having a stopper pierceable by a hypodermic injection needle). In some embodiments, the label or package insert indicates that the composition is used for preventing, diagnosing, and/or treating the condition of choice. Alternatively, or additionally, the article of manufacture or kit may further comprise a second (or third) container comprising a pharmaceutically-acceptable buffer, such as bacteriostatic water for injection (BWFI), phosphate-buffered saline, Ringer's solution and dextrose solution. It may further include other materials desirable from a commercial and user standpoint, including other buffers, diluents, filters, needles, and syringes.

    [0586] Therapeutic or pharmaceutical compositions comprising binding proteins are within the scope of the disclosure. Such therapeutic or pharmaceutical compositions can comprise a therapeutically effective amount of a binding protein, or binding protein-drug conjugate, in admixture with a pharmaceutically or physiologically acceptable formulation agent selected for suitability with the mode of administration.

    [0587] Acceptable formulation materials are nontoxic to recipients at the dosages and concentrations employed.

    [0588] The pharmaceutical composition can contain formulation materials for modifying, maintaining, or preserving, for example, the pH, osmolarity, viscosity, clarity, color, isotonicity, odor, sterility, stability, rate of dissolution or release, adsorption, or penetration of the composition. Suitable formulation materials include, but are not limited to, amino acids (such as glycine, glutamine, asparagine, arginine, or lysine), antimicrobials, antioxidants (such as ascorbic acid, sodium sulfite, or sodium hydrogen-sulfite), buffers (such as borate, bicarbonate, Tris-HCl, citrates, phosphates, or other organic acids), bulking agents (such as mannitol or glycine), chelating agents (such as ethylenediamine tetraacetic acid (EDTA)), complexing agents (such as caffeine, polyvinylpyrrolidone, beta-cyclodextrin, or hydroxypropyl-beta-cyclodextrin), fillers, monosaccharides, disaccharides, and other carbohydrates (such as glucose, mannose, or dextrins), proteins (such as serum albumin, gelatin, or immunoglobulins), coloring, flavoring and diluting agents, emulsifying agents, hydrophilic polymers (such as polyvinylpyrrolidone), low molecular weight polypeptides, salt-forming counterions (such as sodium), preservatives (such as benzalkonium chloride, benzoic acid, salicylic acid, thimerosal, phenethyl alcohol, methylparaben, propylparaben, chlorhexidine, sorbic acid, or hydrogen peroxide), solvents (such as glycerin, propylene glycol, or polyethylene glycol), sugar alcohols (such as mannitol or sorbitol), suspending agents, surfactants or wetting agents (such as pluronics; PEG; sorbitan esters; polysorbates such as polysorbate 20 or polysorbate 80; triton, tromethamine, lecithin; cholesterol or tyloxapal), stability enhancing agents (such as sucrose or sorbitol), tonicity enhancing agents (such as alkali metal halidese.g., sodium or potassium chlorideor mannitol sorbitol), delivery vehicles, diluents, excipients and/or pharmaceutical adjuvants (see, e.g., REMINGTON'S PHARMACEUTICAL SCIENCES (18th Ed., A. R. Gennaro, ed., Mack Publishing Company 1990), and subsequent editions of the same, incorporated herein by reference for any purpose).

    [0589] The optimal pharmaceutical composition will be determined by a skilled artisan depending upon, for example, the intended route of administration, delivery format, and desired dosage. Such compositions can influence the physical state, stability, rate of in vivo release, and rate of in vivo clearance of the binding protein.

    [0590] The primary vehicle or carrier in a pharmaceutical composition can be either aqueous or non-aqueous in nature. For example, a suitable vehicle or carrier for injection can be water, physiological saline solution, or artificial cerebrospinal fluid, possibly supplemented with other materials common in compositions for parenteral administration. Neutral buffered saline or saline mixed with serum albumin are further exemplary vehicles. Other exemplary pharmaceutical compositions comprise Tris buffer of about pH 7.0-8.5, or acetate buffer of about pH 4.0-5.5, which can further include sorbitol or a suitable substitute. In one embodiment of the disclosure, binding protein compositions can be prepared for storage by mixing the selected composition having the desired degree of purity with optional formulation agents in the form of a lyophilized cake or an aqueous solution. Further, the binding protein can be formulated as a lyophilizate using appropriate excipients such as sucrose.

    [0591] The pharmaceutical compositions of the disclosure can be selected for parenteral delivery or subcutaneous. Alternatively, the compositions can be selected for inhalation or for delivery through the digestive tract, such as orally. The preparation of such pharmaceutically acceptable compositions is within the skill of the art.

    [0592] The formulation components are present in concentrations that are acceptable to the site of administration. For example, buffers are used to maintain the composition at physiological pH or at a slightly lower pH, typically within a pH range of from about 5 to about 8.

    [0593] When parenteral administration is contemplated, the therapeutic compositions for use can be in the form of a pyrogen-free, parenterally acceptable, aqueous solution comprising the desired binding protein in a pharmaceutically acceptable vehicle. A particularly suitable vehicle for parenteral injection is sterile distilled water in which a binding protein is formulated as a sterile, isotonic solution, properly preserved. Yet another preparation can involve the formulation of the desired molecule with an agent, such as injectable microspheres, bio-erodible particles, polymeric compounds (such as polylactic acid or polyglycolic acid), beads, or liposomes, that provides for the controlled or sustained release of the product which can then be delivered via a depot injection. Hyaluronic acid can also be used, and this can have the effect of promoting sustained duration in the circulation. Other suitable means for the introduction of the desired molecule include implantable drug delivery devices.

    [0594] In one embodiment, a pharmaceutical composition can be formulated for inhalation. For example, a binding protein can be formulated as a dry powder for inhalation. Binding protein inhalation solutions can also be formulated with a propellant for aerosol delivery. In yet another embodiment, solutions can be nebulized.

    [0595] It is also contemplated that certain formulations can be administered orally. In one embodiment of the disclosure, binding proteins that are administered in this fashion can be formulated with or without those carriers customarily used in the compounding of solid dosage forms such as tablets and capsules. For example, a capsule can be designed to release the active portion of the formulation at the point in the gastrointestinal tract where bioavailability is maximized and pre-systemic degradation is minimized. Additional agents can be included to facilitate absorption of the binding protein. Diluents, flavorings, low melting point waxes, vegetable oils, lubricants, suspending agents, tablet disintegrating agents, and binders can also be employed.

    [0596] Another pharmaceutical composition can involve an effective quantity of binding proteins in a mixture with non-toxic excipients that are suitable for the manufacture of tablets. By dissolving the tablets in sterile water, or another appropriate vehicle, solutions can be prepared in unit-dose form. Suitable excipients include, but are not limited to, inert diluents, such as calcium carbonate, sodium carbonate or bicarbonate, lactose, or calcium phosphate, or binding agents, such as starch, gelatin, or acacia; or lubricating agents such as magnesium stearate, stearic acid, or talc.

    [0597] Additional pharmaceutical compositions of the disclosure will be evident to those skilled in the art, including formulations involving binding proteins in sustained- or controlled-delivery formulations. Techniques for formulating a variety of other sustained- or controlled-delivery means, such as liposome carriers, bio-erodible microparticles or porous beads and depot injections, are also known to those skilled in the art. Additional examples of sustained-release preparations include semipermeable polymer matrices in the form of shaped articles, e.g. films, or microcapsules. Sustained release matrices can include polyesters, hydrogels, polylactides, copolymers of L-glutamic acid and gamma ethyl-L-glutamate, poly(2-hydroxyethyl-methacrylate), ethylene vinyl acetate, or poly-D()-3-hydroxybutyric acid. Sustained-release compositions can also include liposomes, which can be prepared by any of several methods known in the art.

    [0598] Pharmaceutical compositions to be used for in vivo administration typically must be sterile. This can be accomplished by filtration through sterile filtration membranes. Where the composition is lyophilized, sterilization using this method can be conducted either prior to, or following, lyophilization and reconstitution. The composition for parenteral administration can be stored in lyophilized form or in a solution. In addition, parenteral compositions generally are placed into a container having a sterile access port, for example, an intravenous solution bag or vial having a stopper pierceable by a hypodermic injection needle.

    [0599] Once the pharmaceutical composition has been formulated, it can be stored in sterile vials as a solution, suspension, gel, emulsion, solid, or as a dehydrated or lyophilized powder. Such formulations can be stored either in a ready-to-use form or in a form (e.g., lyophilized) requiring reconstitution prior to administration.

    [0600] The disclosure also encompasses kits for producing a single-dose administration unit. The kits can each contain both a first container having a dried protein and a second container having an aqueous formulation. Also included within the scope of this disclosure are kits containing single and multi-chambered pre-filled syringes (e.g., liquid syringes and lyosyringes).

    [0601] The effective amount of a binding protein pharmaceutical composition to be employed therapeutically will depend, for example, upon the therapeutic context and objectives. One skilled in the art will appreciate that the appropriate dosage levels for treatment will thus vary depending, in part, upon the molecule delivered, the indication for which the binding protein is being used, the route of administration, and the size (body weight, body surface, or organ size) and condition (the age and general health) of the patient. Accordingly, the clinician can titer the dosage and modify the route of administration to obtain the optimal therapeutic effect.

    [0602] Dosing frequency will depend upon the pharmacokinetic parameters of the binding protein in the formulation being used. Typically, a clinician will administer the composition until a dosage is reached that achieves the desired effect. The composition can therefore be administered as a single dose, as two or more doses (which may or may not contain the same amount of the desired molecule) over time, or as a continuous infusion via an implantation device or catheter. Further refinement of the appropriate dosage is routinely made by those of ordinary skill in the art and is within the ambit of tasks routinely performed by them. Appropriate dosages can be ascertained through use of appropriate dose-response data.

    [0603] The route of administration of the pharmaceutical composition is in accord with known methods, e.g., orally; through injection by intravenous, intraperitoneal, intracerebral (intraparenchymal), intracerebroventricular, intramuscular, intraocular, intraarterial, intraportal, or intralesional routes; by sustained release systems; or by implantation devices. Where desired, the compositions can be administered by bolus injection or continuously by infusion, or by implantation device.

    [0604] The composition can also be administered locally via implantation of a membrane, sponge, or other appropriate material onto which the desired molecule has been absorbed or encapsulated. Where an implantation device is used, the device can be implanted into any suitable tissue or organ, and delivery of the desired molecule can be via diffusion, timed-release bolus, or continuous administration.

    [0605] The pharmaceutical compositions can be used to prevent and/or treat HIV infection. The pharmaceutical compositions can be used as a standalone therapy or in combination with standard anti-retroviral therapy.

    [0606] In some embodiments, the present disclosure relates to a method of preventing and/or treating HIV infection in a patient. In some embodiments, the method comprises administering to the patient a therapeutically effective amount of at least one of the binding proteins described herein. In some embodiments, the at least one binding protein is administered in combination with an anti-retroviral therapy (e.g., an anti-HIV therepy). In some embodiments, the at least one binding protein is administered before the anti-retroviral therapy. In some embodiments, the at least one binding protein is administered concurrently with the anti-retroviral therapy. In some embodiments, the at least one binding protein is administered after the anti-retroviral therapy. In some embodiments, the at least one binding protein is co-administered with any standard anti-retroviral therapy known in the art. In some embodiments, administration of the at least one binding protein results in neutralization of one or more HIV virions. In some embodiments, administration of the at least one binding protein results in elimination of one or more latently and/or chronically HIV-infected cells in the patient. In some embodiments, administration of the at least one binding protein results in neutralization of one or more HIV virions and results in elimination of one or more latently and/or chronically HIV-infected cells in the patient. In some embodiments, the patient is a human.

    [0607] Without limiting the present disclosure, a number of embodiments of the present disclosure are described below for purpose of illustration.

    [0608] Item 1: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00073## [0609] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00074## [0610] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00075## [0611] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00076## [0612] wherein: [0613] V.sub.L1 is a first immunoglobulin light chain variable domain; [0614] V.sub.L2 is a second immunoglobulin light chain variable domain; [0615] V.sub.L3 is a third immunoglobulin light chain variable domain; [0616] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0617] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0618] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0619] C.sub.L is an immunoglobulin light chain constant domain; [0620] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; and [0621] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers; [0622] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0623] Item 2: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00077## [0624] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00078## [0625] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00079## [0626] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00080## [0627] wherein: [0628] V.sub.L1 is a first immunoglobulin light chain variable domain; [0629] V.sub.L2 is a second immunoglobulin light chain variable domain; [0630] V.sub.L3 is a third immunoglobulin light chain variable domain; [0631] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0632] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0633] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0634] C.sub.L is an immunoglobulin light chain constant domain; [0635] C.sub.H1 is an immunoglobulin C.sub.H1 heavy chain constant domain; [0636] C.sub.H2 is an immunoglobulin C.sub.H2 heavy chain constant domain; [0637] C.sub.H3 is an immunoglobulin C.sub.H3 heavy chain constant domain; [0638] hinge is an immunoglobulin hinge region connecting the C.sub.H1 and C.sub.H2 domains; and [0639] L.sub.1, L.sub.2, L.sub.3 and L.sub.4 are amino acid linkers; [0640] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0641] Item 3: The binding protein of item 1 or item 2, wherein the one or more HIV target proteins is selected from the group consisting of glycoprotein 120, glycoprotein 41 and glycoprotein 60.

    [0642] Item 4: The binding protein of item 1 or item 2, wherein the binding protein is trispecific and capable of specifically binding three different epitopes on a single HIV target protein.

    [0643] Item 5: The binding protein of item 1 or item 2, wherein the binding protein is trispecific and capable of specifically binding two different epitopes on a first HIV target protein, and one epitope on a second HIV target protein, wherein the first and second HIV target proteins are different.

    [0644] Item 6: The binding protein of item 1 or item 2, wherein the binding protein is trispecific and capable of specifically binding three different antigen targets.

    [0645] Item 7: The binding protein of item 1 or item 2, wherein the binding protein is capable of inhibiting the function of one or more HIV target proteins.

    [0646] Item 8: The binding protein of any one of items 1-7, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; or a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively.

    [0647] Item 9: The binding protein of any one of items 1-7, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521.

    [0648] Item 10: The binding protein of any one of items 1-9, wherein V.sub.L1 comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521.

    [0649] Item 11: The binding protein of any one of items 1-10, wherein V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; or a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively.

    [0650] Item 12: The binding protein of any one of items 1-10, wherein V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521.

    [0651] Item 13: The binding protein of any one of items 1-12, wherein V.sub.L2 comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521.

    [0652] Item 14: The binding protein of any one of items 1-13, wherein VU comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; or a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively.

    [0653] Item 15: The binding protein of any one of items 1-13, wherein V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521.

    [0654] Item 16: The binding protein of any one of items 1-15, wherein V.sub.L3 comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, and 521.

    [0655] Item 17: The binding protein of any one of items 1-16, wherein V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively, or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively.

    [0656] Item 18: The binding protein of any one of items 1-16, wherein V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508.

    [0657] Item 19: The binding protein of any one of items 1-18, wherein V.sub.H1 comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508.

    [0658] Item 20: The binding protein of any one of items 1-19, wherein V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively, or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively.

    [0659] Item 21: The binding protein of any one of items 1-19, wherein V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508.

    [0660] Item 22: The binding protein of any one of items 1-21, wherein V.sub.H2 comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508.

    [0661] Item 23: The binding protein of any one of items 1-22, wherein V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; or a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively.

    [0662] Item 24: The binding protein of any one of items 1-22, wherein V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508.

    [0663] Item 25: The binding protein of any one of items 1-24, wherein V.sub.H3 comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, and 508.

    [0664] Item 26: The binding protein of any one of items 1-25, wherein V.sub.L1 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of GKN, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V.sub.L2 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of LAS, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V.sub.L3 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 266, a CDR-L2 comprising the sequence of SEQ ID NO: 267, and a CDR-L3 comprising the sequence of SEQ ID NO: 268; V.sub.H1 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; V.sub.H2 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; and V.sub.H3 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 248, a CDR-H2 comprising the sequence of SEQ ID NO: 497, and a CDR-H3 comprising the sequence of SEQ ID NO: 250.

    [0665] Item 27: The binding protein of any one of items 1-25, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 512; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 502.

    [0666] Item 28: The binding protein of any one of items 1-27, wherein V.sub.L1 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V.sub.L2 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V.sub.L3 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 512; V.sub.H1 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; V.sub.H2 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; and V.sub.H3 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 502.

    [0667] Item 29: The binding protein of any one of items 1-25, wherein V.sub.L1 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of GKN, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V.sub.L2 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of LAS, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V.sub.L3 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of HTS, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V.sub.H1 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; V.sub.H2 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; and V.sub.H3 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253.

    [0668] Item 30: The binding protein of any one of items 1-25, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503.

    [0669] Item 31: The binding protein of any one of items 1-25 and 29-30, wherein V.sub.L1 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V.sub.L2 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V.sub.L3 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V.sub.H1 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; V.sub.H2 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; and V.sub.H3 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503.

    [0670] Item 32: The binding protein of any one of items 1-25, wherein V.sub.L1 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 275, a CDR-L2 comprising the sequence of LAS, and a CDR-L3 comprising the sequence of SEQ ID NO: 277; V.sub.L2 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 500, a CDR-L2 comprising the sequence of GKN, and a CDR-L3 comprising the sequence of SEQ ID NO: 274; V.sub.L3 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of HTS, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V.sub.H1 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 257, a CDR-H2 comprising the sequence of SEQ ID NO: 258, and a CDR-H3 comprising the sequence of SEQ ID NO: 259; V.sub.H2 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 254, a CDR-H2 comprising the sequence of SEQ ID NO: 255, and a CDR-H3 comprising the sequence of SEQ ID NO: 256; and V.sub.H3 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253.

    [0671] Item 33: The binding protein of any one of items 1-25, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 519, V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 518; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 506; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 504; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503.

    [0672] Item 34: The binding protein of any one of items 1-25 and 32-33, wherein V.sub.L1 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 519; V.sub.L2 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 518; V.sub.L3 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V.sub.H1 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 506; V.sub.H2 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 504; and V.sub.H3 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503.

    [0673] Item 35: The binding protein of item 1, wherein the second polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0674] Item 36: The binding protein of item 1, wherein the third polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0675] Item 37: The binding protein of item 1, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V.

    [0676] Item 38: The binding protein of item 1, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0677] Item 39: The binding protein of any one of items 1, 37, and 38, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0678] Item 40: The binding protein of item 2, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V.

    [0679] Item 41: The binding protein of item 2, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0680] Item 42: The binding protein of any one of items 2, 40, and 41, wherein the C.sub.H3 domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0681] Item 43: The binding protein of item 1 or item 2, wherein at least one of L.sub.1, L.sub.2, L.sub.3, or L.sub.4 is independently 0 amino acids in length.

    [0682] Item 44: The binding protein of item 1 or item 2, wherein L.sub.1, L.sub.2, L.sub.3, or L.sub.4 are each independently at least one amino acid in length.

    [0683] Item 45: The binding protein of any one of items 1-44, wherein L.sub.1 comprises Asp-Lys-Thr-His-Thr (SEQ ID NO: 525).

    [0684] Item 46: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00081## [0685] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00082## [0686] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00083## [0687] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00084## [0688] wherein: [0689] V.sub.L1 is a first immunoglobulin light chain variable domain; [0690] V.sub.L2 is a second immunoglobulin light chain variable domain; [0691] V.sub.L3 is a third immunoglobulin light chain variable domain; [0692] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0693] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0694] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0695] C.sub.L is an immunoglobulin light chain constant domain; [0696] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; and [0697] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers; [0698] wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair; [0699] wherein: [0700] (a) V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210, 212, 218, 220, 226, 228, 233, 235, 241, 243; or [0701] (b) V.sub.L1, V.sub.L2 and V.sub.L3 each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs:266-283; and [0702] wherein: [0703] (a) V.sub.H1, V.sub.H2, and V.sub.H3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242; or [0704] (b) V.sub.H1, V.sub.H2, and V.sub.H3 each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265.

    [0705] Item 47: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00085## [0706] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00086## [0707] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00087## [0708] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00088## [0709] wherein: [0710] V.sub.L1 is a first immunoglobulin light chain variable domain; [0711] V.sub.L2 is a second immunoglobulin light chain variable domain; [0712] V.sub.L3 is a third immunoglobulin light chain variable domain; [0713] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0714] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0715] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0716] C.sub.L is an immunoglobulin light chain constant domain; [0717] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; [0718] C.sub.H2 is an immunoglobulin C.sub.H2 heavy chain constant domain; [0719] C.sub.H3 is an immunoglobulin C.sub.H3 heavy chain constant domain; [0720] hinge is an immunoglobulin hinge region connecting the C.sub.H1 and C.sub.H2 domains; and [0721] L.sub.1, L.sub.2, L.sub.3, and La are amino acid linkers; [0722] wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair; [0723] wherein: [0724] (a) V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4, 10, 12, 18, 20, 26, 28, 34, 36, 42, 44, 50, 52, 58, 60, 66, 68, 74, 76, 82, 84, 90, 92, 98, 100, 106, 108, 114, 116, 122, 124, 130, 132, 138, 140, 146, 148, 154, 156, 162, 164, 170, 172, 178, 180, 186, 188, 194, 196, 202, 204, 210,212, 218, 220, 226, 228, 233, 235, 241, 243; or [0725] (b) V.sub.L1, V.sub.L2 and V.sub.L3 each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs:266-283; and [0726] wherein: [0727] (a) V.sub.H1, V.sub.H2 and V.sub.H3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 1, 3, 9, 11, 17, 10, 25, 27, 33, 35, 41, 43, 49, 51, 57, 59, 65, 67, 73, 75, 81, 83, 89, 91, 97, 99, 105, 107, 113, 115, 121, 123, 129, 131, 137, 139, 145, 147, 153, 155, 161, 163, 169, 171, 177, 179, 185, 187, 193, 195, 201, 203, 209, 211, 217, 219, 225, 227, 232, 234, 240, 242; or [0728] (b) V.sub.H1, V.sub.H2, and V.sub.H3 each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-265.

    [0729] Item 48: The binding protein of item 46, wherein the second polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0730] Item 49: The binding protein of item 46, wherein the third polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0731] Item 50: The binding protein of item 46, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V.

    [0732] Item 51: The binding protein of item 46, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0733] Item 52: The binding protein of any one of items 46, 50, and 51, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0734] Item 53: The binding protein of item 47, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V.

    [0735] Item 54: The binding protein of item 47, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0736] Item 55: The binding protein of any one of items 47, 53, and 54, wherein the C.sub.H3 domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0737] Item 56: The binding protein of item 46 or item 47, wherein at least one of L.sub.1, L.sub.2, L.sub.3 or L.sub.4 is independently 0 amino acids in length.

    [0738] Item 57: The binding protein of item 46 or item 47, wherein L.sub.1, L.sub.2. L.sub.3 or L.sub.4 are each independently at least one amino acid in length.

    [0739] Item 58: The binding protein of any one of items 46-57, wherein L.sub.1 comprises Asp-Lys-Thr-His-Thr (SEQ ID NO: 525).

    [0740] Item 59: A binding protein comprising a first polypeptide chain, a second polypeptide chain, a third polypeptide chain and a fourth polypeptide chain wherein: [0741] (a) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 4 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 4; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 3; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 1; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2; [0742] (b) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 12 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 12; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 11 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 11; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 9 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 9; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 10 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 10; [0743] (c) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 20 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 20; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 19; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 17 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 17; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 18 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 18; [0744] (d) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 28 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 28; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 27 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 27; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 25 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 25; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 26 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 26; [0745] (e) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 36; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 35 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 35; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 33 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 33; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 34 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 34; [0746] (f) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 44 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 44; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 43 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 43; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 41 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 41; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 42 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 42; [0747] (g) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 52 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 52; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 51 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 51; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 49 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 49, and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 50 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 50; [0748] (h) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 60 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 60; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 59 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 59; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 57 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 57; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 58 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 58; [0749] (i) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 68 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 68; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 67 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 67; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 65 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 65; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 66 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 66; [0750] (j) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 76 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 76; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 75 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 75, the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 73 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 73; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 74 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 74; [0751] (k) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 84 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 84; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 83 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 83; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 81 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 81; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 82 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 82; [0752] (l) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 92 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:92; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 91 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 91; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 89 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 89; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 90 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 90; [0753] (m) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 100 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 100; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 99 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 99; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 97 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 97; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 98 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 98; [0754] (n) the first polypeptide comprises the amino acid sequence of SEQ ID NO: 108 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 108; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 107 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 107, the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 105 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 105; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 106 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 106; [0755] (o) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 116 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 116; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 115 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 115; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 113 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 113; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 114 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 114; [0756] (p) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 124 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 124; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 123 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 123; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 121 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 121; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 122 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 122; [0757] (q) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 132 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 132; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 131 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 131; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 129 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 129; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 130 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 130; [0758] (r) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 140 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 140; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 139 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 139; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 137 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 137; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 138; [0759] (s) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 148 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 148; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 147 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 147; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 145 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 145; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 146 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 146; [0760] (t) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 156 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 156; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 155 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 155; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 153 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 153; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 154 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 154; [0761] (u) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 164 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 164; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 163 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 163; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 161 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 161; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 162 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 162; [0762] (v) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 172 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 172; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 171 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 171; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 169 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 169; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 170 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 170; [0763] (w) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 180 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 180; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 179 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 179; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 177 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 177; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 178 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 178; [0764] (x) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 188 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 188; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 187 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 187; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 185 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 185; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 186 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 186; [0765] (y) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 196 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 196; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 195 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 195; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 193 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 193; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 194 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 194; [0766] (z) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 204 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 204; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 203 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 203; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 201 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 201; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 202 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 202; [0767] (aa) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 212 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 212; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 211 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 211; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 209 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 209; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 210 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 210; [0768] (bb) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 220 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 220; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 219 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 219; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 217 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 217; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 218 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 218; [0769] (cc) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 228 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 228; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 227 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 227; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 225 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 225; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 226 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 226; [0770] (dd) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 235 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 235; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 234 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 234; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 232 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 232; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 233 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 233; or [0771] (ee) first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 243 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 243; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 242 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 242; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 240 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 240; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 241 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 241.

    [0772] Item 60: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins and one or more T cell target proteins, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00089## [0773] a second polypeptide chain comprises a structure represented by the formula:

    ##STR00090## [0774] a third polypeptide chain comprises a structure represented by the formula:

    ##STR00091## [0775] and a fourth polypeptide chain comprises a structure represented the formula:

    ##STR00092## [0776] wherein [0777] V.sub.L1 is a first immunoglobulin light chain variable domain; [0778] V.sub.L2 is a second immunoglobulin light chain variable domain; [0779] V.sub.L3 is a third immunoglobulin light chain variable domain; [0780] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0781] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0782] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0783] C.sub.L is an immunoglobulin light chain constant domain; [0784] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; and [0785] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers, [0786] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0787] Item 61: A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins and one or more T cell target proteins, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00093## [0788] a second polypeptide chain comprises a structure represented by the formula:

    ##STR00094## [0789] a third polypeptide chain comprises a structure represented by the formula:

    ##STR00095## [0790] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00096## [0791] wherein [0792] V.sub.L1 is a first immunoglobulin light chain variable domain; [0793] V.sub.L2 is a second immunoglobulin light chain variable domain; [0794] V.sub.L3 is a third immunoglobulin light chain variable domain; [0795] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0796] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0797] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0798] C.sub.L is an immunoglobulin light chain constant domain; [0799] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; [0800] C.sub.H2 is an immunoglobulin C.sub.H2 heavy chain constant domain; [0801] C.sub.H3 is an immunoglobulin C.sub.H3 heavy chain constant domain; [0802] hinge is an immunoglobulin hinge region connecting the C.sub.H1 and C.sub.H2 domains; and [0803] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers; [0804] and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.

    [0805] Item 62: The binding protein of item 60 or item 61, wherein the one or more HIV target proteins are selected from the group consisting of glycoprotein 120, glycoprotein 41 and glycoprotein 160.

    [0806] Item 63: The binding protein of item 60 or item 61, wherein the one or more T cell target proteins are CD3 or CD28.

    [0807] Item 64: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding an HIV target protein and two different epitopes on a single T cell target protein.

    [0808] Item 65: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding an HIV target protein and two different T cell target proteins.

    [0809] Item 66: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding a T cell target protein and two different epitopes on a single HIV target protein.

    [0810] Item 67: The binding protein of item 60 or item 61, wherein the binding protein is trispecific and capable of specifically binding a T cell target protein and two different HIV target proteins.

    [0811] Item 68: The binding protein of item 60 or item 61, wherein the first and second polypeptide chains form two antigen binding sites that specifically target two T cell target proteins, and the third and fourth polypeptide chains form an antigen binding site that specifically binds an HIV target protein.

    [0812] Item 69: The binding protein of any one of items 60-68, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively; a sequence as set forth in SEQ ID NO:488, KAS, and SEQ ID NO:490, respectively; a sequence as set forth in SEQ ID NO:491, AAS, and SEQ ID NO:493, respectively; or a sequence as set forth in SEQ ID NO:494, KVS, and SEQ ID NO:4%, respectively.

    [0813] Item 70: The binding protein of any one of items 60-68, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0814] Item 71: The binding protein of any one of items 60-70, wherein V.sub.L1 comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0815] Item 72: The binding protein of any one of items 60-71, wherein V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively; a sequence as set forth in SEQ ID NO:488, KAS, and SEQ ID NO:490, respectively; a sequence as set forth in SEQ ID NO:491, AAS, and SEQ ID NO:493, respectively; or a sequence as set forth in SEQ ID NO:494, KVS, and SEQ ID NO:4%, respectively.

    [0816] Item 73: The binding protein of any one of items 60-71, wherein V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0817] Item 74: The binding protein of any one of items 60-73, wherein V.sub.L2 comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0818] Item 75: The binding protein of any one of items 60-74, wherein V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 comprising a sequence as set forth in SEQ ID NOs: 266, 267, and 268, respectively; a sequence as set forth in SEQ ID NO:269, HTS, and SEQ ID NO:271, respectively; a sequence as set forth in SEQ ID NO:500, GKN, and SEQ ID NO:274, respectively; a sequence as set forth in SEQ ID NO:275, Leu Ala Ser, and SEQ ID NO:277, respectively; a sequence as set forth in SEQ ID NO:281, ETD, and SEQ ID NO:283, respectively; a sequence as set forth in SEQ ID NO:278, NNQ, and SEQ ID NO:280, respectively; a sequence as set forth in SEQ ID NO:488, KAS, and SEQ ID NO:490, respectively; a sequence as set forth in SEQ ID NO:491, AAS, and SEQ ID NO:493, respectively, or a sequence as set forth in SEQ ID NO:494, KVS, and SEQ ID NO:4%, respectively.

    [0819] Item 76: The binding protein of any one of items 60-74, wherein V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0820] Item 77: The binding protein of any one of items 60-76, wherein V.sub.L3 comprises a light chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, and 524.

    [0821] Item 78: The binding protein of any one of items 60-77, wherein V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively.

    [0822] Item 79: The binding protein of any one of items 60-77, wherein V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0823] Item 80: The binding protein of any one of items 60-79, wherein V.sub.H1 comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0824] Item 81: The binding protein of any one of items 60-80, wherein V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively.

    [0825] Item 82: The binding protein of any one of items 60-80, wherein V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0826] Item 83: The binding protein of any one of items 60-82, wherein V.sub.H2 comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0827] Item 84: The binding protein of any one of items 60-83, wherein V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 comprising a sequence as set forth in SEQ ID NOs: 248, 497, and 250, respectively; a sequence as set forth in SEQ ID NOs: 251, 252, and 253, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 256, respectively; a sequence as set forth in SEQ ID NOs: 254, 255, and 498, respectively; a sequence as set forth in SEQ ID NOs: 257, 258, and 259, respectively; a sequence as set forth in SEQ ID NOs: 263, 264, and 265, respectively; a sequence as set forth in SEQ ID NOs: 499, 261, and 262, respectively; a sequence as set forth in SEQ ID NOs: 479, 480, and 481, respectively; a sequence as set forth in SEQ ID NOs: 482, 483, and 484, respectively; or a sequence as set forth in SEQ ID NOs: 485, 486, and 487, respectively.

    [0828] Item 85: The binding protein of any one of items 60-83, wherein V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0829] Item 86: The binding protein of any one of items 60-85, wherein V.sub.H3 comprises a heavy chain variable domain comprising a sequence selected from the group consisting of SEQ ID NOs: 502, 503, 504, 505, 506, 507, 508, 509, 510, and 511.

    [0830] Item 87: The binding protein of any one of items 60-86, wherein V.sub.L1 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 488, a CDR-L2 comprising the sequence of KAS, and a CDR-L3 comprising the sequence of SEQ ID NO: 490; V.sub.L2 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 494, a CDR-L2 comprising the sequence of KVS, and a CDR-L3 comprising the sequence of SEQ ID NO: 496; V.sub.L3 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of HTS, and a CDR-L3 comprising the sequence of SEQ ID NO: 271; V.sub.H1 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 479, a CDR-H2 comprising the sequence of SEQ ID NO: 480, and a CDR-H3 comprising the sequence of SEQ ID NO: 481; V.sub.H2 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 485, a CDR-H2 comprising the sequence of SEQ ID NO: 486, and a CDR-H3 comprising the sequence of SEQ ID NO: 487; and V.sub.H3 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253.

    [0831] Item 88: The binding protein of any one of items 60-86, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 522; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 524; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 509; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 511; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503.

    [0832] Item 89: The binding protein of any one of items 60-88, wherein V.sub.L1 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 522; V.sub.L2 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 524; V.sub.L3 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V.sub.H1 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 509; V.sub.H2 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 511; and V.sub.H3 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503.

    [0833] Item 90: The binding protein of any one of items 60-86, wherein V.sub.L1 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 494, a CDR-L2 comprising the sequence of KVS, and a CDR-L3 comprising the sequence of SEQ ID NO: 496; V.sub.L2 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 488, a CDR-L2 comprising the sequence of KAS, and a CDR-L3 comprising the sequence of SEQ ID NO: 490; V.sub.L3 comprises a CDR-L1 comprising the sequence of SEQ ID NO: 269, a CDR-L2 comprising the sequence of HTS, and a CDR-L3 comprising the sequence of SEQ ID NO: 271, V.sub.H1 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 485, a CDR-H2 comprising the sequence of SEQ ID NO: 486, and a CDR-H3 comprising the sequence of SEQ ID NO: 487; V.sub.H2 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 479, a CDR-H2 comprising the sequence of SEQ ID NO: 480, and a CDR-H3 comprising the sequence of SEQ ID NO: 481; and V.sub.H3 comprises a CDR-H1 comprising the sequence of SEQ ID NO: 251, a CDR-H2 comprising the sequence of SEQ ID NO: 252, and a CDR-H3 comprising the sequence of SEQ ID NO: 253.

    [0834] Item 91: The binding protein of any one of items 60-86, wherein V.sub.L1 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 524; V.sub.L2 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 522; V.sub.L3 comprises a CDR-L1, CDR-L2, and CDR-L3 of a light chain variable domain comprising the light chain variable domain sequence of SEQ ID NO: 513; V.sub.H1 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 511; V.sub.H2 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 509; and V.sub.H3 comprises a CDR-H1, CDR-H2, and CDR-H3 of a heavy chain variable domain comprising the heavy chain variable domain sequence of SEQ ID NO: 503.

    [0835] Item 92: The binding protein of any one of items 60-86 and 90-91, wherein V.sub.L1 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 524; V.sub.L2 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 522; V.sub.L3 comprises a light chain variable domain comprising the sequence of SEQ ID NO: 513; V.sub.H1 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 511; V.sub.H2 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 509; and V.sub.H3 comprises a heavy chain variable domain comprising the sequence of SEQ ID NO: 503.

    [0836] Item 93: The binding protein of item 60, wherein the second polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0837] Item 94: The binding protein of item 60, wherein the third polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3; immunoglobulin heavy chain constant domains.

    [0838] Item 95: The binding protein of item 60, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and H12 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V.

    [0839] Item 96: The binding protein of item 60, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0840] Item 97: The binding protein of any one of items 60, 95, and 96, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0841] Item 98: The binding protein of item 61, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S. L368A, and Y407V.

    [0842] Item 99: The binding protein of item 61, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0843] Item 100: The binding protein of any one of items 61, 98, and 99, wherein the C.sub.H3 domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0844] Item 101: The binding protein of item 60 or item 61, wherein at least one of L.sub.1, L.sub.2, L.sub.3, or La is independently 0 amino acids in length.

    [0845] Item 102: The binding protein of item 60 or item 61, wherein L.sub.1, L.sub.2, L.sub.3, or L are each independently at least one amino acid in length.

    [0846] Item 103: The binding protein of any one of items 60-102, wherein L.sub.1 is Gly-Gln-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299).

    [0847] Item 104: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00097## [0848] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00098## [0849] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00099## [0850] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00100## [0851] wherein: [0852] V.sub.L1 is a first immunoglobulin light chain variable domain; [0853] V.sub.L2 is a second immunoglobulin light chain variable domain; [0854] V.sub.L3 is a third immunoglobulin light chain variable domain; [0855] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0856] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0857] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0858] C.sub.L is an immunoglobulin light chain constant domain; [0859] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; and [0860] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers; [0861] wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair; [0862] wherein: [0863] (a) V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; or [0864] (b) V.sub.L1, V.sub.L2 and V.sub.L3 each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488-496; and [0865] wherein: [0866] (a) V.sub.H1, V.sub.H2, and V.sub.H3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472; or [0867] (b) V.sub.H1, V.sub.H2, and V.sub.H3 each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487.

    [0868] Item 105: A binding protein comprising four polypeptide chains that form three antigen binding sites, wherein a first polypeptide chain comprises a structure represented by the formula:

    ##STR00101## [0869] and a second polypeptide chain comprises a structure represented by the formula:

    ##STR00102## [0870] and a third polypeptide chain comprises a structure represented by the formula:

    ##STR00103## [0871] and a fourth polypeptide chain comprises a structure represented by the formula:

    ##STR00104## [0872] wherein: [0873] V.sub.L1 is a first immunoglobulin light chain variable domain; [0874] V.sub.L2 is a second immunoglobulin light chain variable domain; [0875] V.sub.L3 is a third immunoglobulin light chain variable domain; [0876] V.sub.H1 is a first immunoglobulin heavy chain variable domain; [0877] V.sub.H2 is a second immunoglobulin heavy chain variable domain; [0878] V.sub.H3 is a third immunoglobulin heavy chain variable domain; [0879] C.sub.L is an immunoglobulin light chain constant domain; [0880] C.sub.H1 is the immunoglobulin C.sub.H1 heavy chain constant domain; [0881] C.sub.H2 is an immunoglobulin C.sub.H2 heavy chain constant domain; [0882] C.sub.H3 is an immunoglobulin C.sub.H3 heavy chain constant domain; [0883] hinge is an immunoglobulin hinge region connecting the C.sub.H1 and C.sub.H2 domains; and [0884] L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are amino acid linkers; [0885] wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair; [0886] wherein: [0887] (a) V.sub.L1, V.sub.L2 and V.sub.L3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 303, 305, 311, 313, 319, 321, 327, 329, 335, 337, 343, 345, 351, 353, 359, 361, 367, 369, 375, 377, 383, 385, 391, 393, 399, 401, 407, 409, 415, 417, 423, 425, 431, 433, 439, 441, 447, 449, 455, 457, 463, 465, 471, 473; or [0888] (b) V.sub.L1, V.sub.L2 and V.sub.L3 each independently comprise light chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 266-271, 275-277, 488496; and [0889] wherein: [0890] (a) V.sub.H1, V.sub.H2, and V.sub.H3 are each independently a variable domain derived from an amino acid sequence as set forth in any one of SEQ ID NOs: 302, 304, 310, 312, 318, 320, 326, 328, 334, 336, 342, 344, 350, 352, 358, 360, 366, 368, 374, 376, 382, 384, 390, 392, 398, 400, 406, 408, 414, 416, 422, 424, 430, 432, 438, 440, 446, 448, 454, 456, 462, 464, 470, 472; or [0891] (b) V.sub.H1, V.sub.H2, and V.sub.H3 each independently comprise heavy chain complementarity determining regions of a variable domain comprising an amino acid sequence as set forth in any one of SEQ ID NOs: 248-253, 257-259, 479-487.

    [0892] Item 106: The binding protein of item 104, wherein the second polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0893] Item 107: The binding protein of item 104, wherein the third polypeptide chain further comprises an Fc region linked to C.sub.H1, the Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains.

    [0894] Item 108: The binding protein of item 104, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V.

    [0895] Item 109: The binding protein of item 104, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the first Fc region comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, wherein the second Fc region comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0896] Item 110: The binding protein of any one of items 104, 108, and 109, wherein the second polypeptide chain further comprises a first Fc region linked to C.sub.H1, the first Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains, and wherein the third polypeptide chain further comprises a second Fc region linked to C.sub.H1, the second Fc region comprising an immunoglobulin hinge region and C.sub.H2 and C.sub.H3 immunoglobulin heavy chain constant domains; wherein the first and second Fc regions comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0897] Item 111: The binding protein of item 105, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V.

    [0898] Item 112: The binding protein of item 105, wherein the C.sub.H3 domain of the second polypeptide chain comprises amino acid substitutions at positions corresponding to positions 349, 366, 368, and 407 of human IgG1 according to EU Index, wherein the amino acid substitutions are Y349C, T366S, L368A, and Y407V; and wherein the C.sub.H3 domain of the third polypeptide chain comprises amino acid substitutions at positions corresponding to positions 354 and 366 of human IgG1 according to EU Index, wherein the amino acid substitutions are S354C and T366W.

    [0899] Item 113: The binding protein of any one of items 105, 111, and 112, wherein the C.sub.H3 domains of the second and the third polypeptide chains both comprise amino acid substitutions at positions corresponding to positions 428 and 434 of human IgG1 according to EU Index, wherein the amino acid substitutions are M428L and N434S.

    [0900] Item 114: The binding protein of item 104 or item 105, wherein at least one of L.sub.1, L.sub.2, L.sub.3, or L.sub.4 is independently 0 amino acids in length.

    [0901] Item 115: The binding protein of item 104 or item 105, wherein L.sub.1, L.sub.2, L.sub.3, or L.sub.4 are each independently at least one amino acid in length.

    [0902] Item 116: The binding protein of any one of items 104-115, wherein L.sub.1 is Gly-Gin-Pro-Lys-Ala-Ala-Pro (SEQ ID NO: 299).

    [0903] Item 117: A binding protein comprising a first polypeptide chain, a second polypeptide chain, a third polypeptide chain and a fourth polypeptide chain wherein: [0904] (a) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 305 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 305; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 304 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 304, the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 302 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 302; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 303 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 303; [0905] (b) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 313 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 313; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 312 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 312; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 310 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 310; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 311 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 311; [0906] (c) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 321 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 321; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 320 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 320; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 318 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 318; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 319 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 319; [0907] (d) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 329 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 329; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 328 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 328; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 326 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 326; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 327 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 327; [0908] (e) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 337 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 337; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 336 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 336; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 334 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 334; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 335 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 335; [0909] (f) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 345 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 345; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 344 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 344; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 342 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 342; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 343 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 343; [0910] (g) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 353 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 353; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 352 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:352; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 350 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 350; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 351 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 351; [0911] (h) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 361 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 361; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 360 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 360; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 358 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 358; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 359 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 359; [0912] (i) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 369 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 369; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 368 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 368; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 366 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 366; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 367 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 367; [0913] (j) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 377 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 377; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 376 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 376; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 374 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 374; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 375 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 375; [0914] (k) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 385 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 385; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 384 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 384; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 382 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 382; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 383 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 383; [0915] (l) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 393 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 393; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 392 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 392; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 390 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 390; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 391 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 391; [0916] (m) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 401 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 401; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 400 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 400; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 398 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 398; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 399 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 399; [0917] (n) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 409 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 409; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 408 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 408; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 406 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 406; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 407 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 407; [0918] (p) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 417 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 417; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 416 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 416; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 414 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 414; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 415 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 415; [0919] (q) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 425 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 425; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 424 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 424; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 422 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 422; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 423 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 423; [0920] (r) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 433 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:433; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 432 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 432; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 430 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 430; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 431 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 431; [0921] (s) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 441 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 441; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 440 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 440; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 438 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 438; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 439 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 439; [0922] (t) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 449 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 449; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 448 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 448; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 446 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 446; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 447 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 447; [0923] (u) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 457 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 457; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 456 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 456; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 454 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 454; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 455 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 455; [0924] (v) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 465 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 465; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 464 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 464; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 462 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 462; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 463 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 463; or [0925] (w) the first polypeptide chain comprises the amino acid sequence of SEQ ID NO: 473 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 473; the second polypeptide chain comprises the amino acid sequence of SEQ ID NO: 472 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 472; the third polypeptide chain comprises the amino acid sequence of SEQ ID NO: 470 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 470; and the fourth polypeptide chain comprises the amino acid sequence of SEQ ID NO: 471 or an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 471.

    [0926] Item 118: An isolated nucleic acid molecule comprising a nucleotide sequence encoding the binding protein of any one of items 1-117.

    [0927] Item 119: An expression vector comprising the nucleic acid molecule of item 118.

    [0928] Item 120: An isolated host cell comprising the nucleic acid molecule of item 118.

    [0929] Item 121: An isolated host cell comprising the expression vector of item 119.

    [0930] Item 122: The isolated host cell of item 120 or item 121, wherein the host cell is a mammalian cell or an insect cell.

    [0931] Item 123: A vector system comprising one or more vectors encoding a first, second, third, and fourth polypeptide chain of a binding protein of any one of items 1-117.

    [0932] Item 124: The vector system of item 123, wherein the vector system comprises a first vector encoding the first polypeptide chain of the binding protein, a second vector encoding the second polypeptide chain of the binding protein, a third vector encoding the third polypeptide chain of the binding protein, and a fourth vector encoding the fourth polypeptide chain of the binding protein.

    [0933] Item 125: The vector system of item 123, wherein the vector system comprises a first vector encoding the first and second polypeptide chains of the binding protein, and a second vector encoding the third and fourth polypeptide chains of the binding protein.

    [0934] Item 126: The vector system of any one of items 123-125, wherein the one or more vectors are expression vectors.

    [0935] Item 127: An isolated host cell comprising the vector system of any one of items 123-126.

    [0936] Item 128: The isolated host cell of item 127, wherein the host cell is a mammalian cell or an insect cell.

    [0937] Item 129: A method of producing a binding protein, the method comprising: a) culturing a host cell of any one of items 120-122 and items 127-128 under conditions such that the host cell expresses the binding protein; and b) isolating the binding protein from the host cell.

    [0938] Item 130: A method of preventing and/or treating HIV infection in a patient comprising administering to the patient a therapeutically effective amount of at least one binding protein of any one of items 1-117.

    [0939] Item 131: The method of item 130, wherein the binding protein is co-administered with standard anti-retroviral therapy.

    [0940] Item 132: The method of item 130 or item 131, wherein administration of the at least one binding protein results in the neutralization of one or more HIV virions.

    [0941] Item 133: The method of any one of items 130-132, wherein administration of the at least one binding protein results in the elimination of one or more latently and/or chronically HIV-infected cells in the patient.

    [0942] Item 134: The method of any one of items 130-133, wherein the patient is a human.

    [0943] Item 135: The binding protein of any one of items 1-117 for the prevention or treatment of an HIV infection in a patient.

    [0944] Item 136: The binding protein of item 135, wherein the binding protein is co-administered with standard anti-retroviral therapy.

    [0945] Item 137: The binding protein of item 135 or item 136, wherein the binding protein causes the neutralization of one or more HIV virions in the patient.

    [0946] Item 138: The binding protein of any one of items 135-137, wherein the binding protein causes the elimination of one or more latently and/or chronically HIV-infected cells in the patient.

    [0947] Item 139: The binding protein of any one of items 135-138, wherein the patient is a human.

    EXAMPLES

    [0948] The Examples that follow are illustrative of specific embodiments of the disclosure, and various uses thereof. They are set forth for explanatory purposes only, and should not be construed as limiting the scope of the invention in any way.

    Example 1: Production of Trispecific Binding Proteins Targeting the HIV-1 Env Glycoprotein

    [0949] The HIV-1 envelope glycoprotein (Env/gp160) is located on the surface of the virus particle, and is composed of a homo-trimer comprising three non-covalently-linked transmembrane gp41 and gp120 complexes. Env enables viral entry into target cells by the binding of gp120 to HIV's main receptor (CD4) and co-receptor (CCR5 or CXCR4), followed by the induction of viral/cellular membrane fusion facilitated by conformational changes in gp41, resulting in entry of the viral capsid and delivery of the viral genome into the host cell. Additionally. Env is expressed on the surface of infected cells.

    [0950] Env acts as the only target for neutralizing antibodies on the HIV-1 virion. Binding of neutralizing antibodies to viral Env inhibits viral attachment/entry. Moreover, binding of neutralizing antibodies to HIV-1 infected, Env expressing cells leads to their destruction by Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement Dependent Cytotoxicity (CDC), resulting in reduction of the latent viral reservoir. Thus, neutralizing antibodies targeting Env are an attractive area for anti-viral therapy development. However, because of the high sequence diversity and mutation rate of the HIV-1 virus, developing neutralizing antibodies targeting Env has proven challenging due to the high likelihood that a given HIV-1 strain either lacks the epitope of any given neutralizing antibody, or the strain has evolved a mutation to become resistant to the antibody. Strategies must be developed to mitigate the breakthrough of viral strains when developing novel neutralizing antibodies targeting HIV-1. The studies described herein explore the development of novel trispecific binding proteins comprising four polypeptides forming three antigen binding sites that specifically bind three different epitopes on the HIV Env glycoprotein, and use of these novel trispecific binding proteins in neutralizing HIV-1.

    Methods

    Binding Protein Production and Purification

    [0951] The vectors expressing the trispecific binding proteins were constructed by inserting the designed heavy and light chain genes into a mammalian expression vector. Corresponding heavy and light chain pairing occurred spontaneously, and heterodimer formation was promoted by Knob-in-Hole mutations engineered in the Fc region.

    [0952] Binding proteins were produced in Expi293 cells by cotransfection of four expression plasmids (Life Technologies, Expi293 Expression System Kit, Cat. No. A14635). Binding proteins were purified using a two-step purification scheme. First, binding proteins were captured on protein A affinity chromatography resin, washed, and then eluted in glycine at pH 3.0. The eluted proteins were then dialyzed in PBS, concentrated, and filtered. The filtered antibodies were further purified using a Superdex 200 SEC column to obtain monomeric binding proteins.

    Affinity Measurements of the Binding Proteins

    [0953] Binding affinities of anti-HIV trispecific binding proteins were measured by surface plasmon resonance (SPR) using a Biacore3000 instrument (GE Healthcare). The assay buffer used was HBS-EP (GE Healthcare).

    [0954] The affinity of the indicated proteins for the MPER binding site on the HIV-1 protein gp41 was measured by surface plasmon resonance (SPR) analysis using a Biacore Instrument as follows: binding proteins were first captured on a CM5 chip coupled with anti-human Fc antibody, followed by flow through of varying concentrations (100 nM-6.25 nM) of the MPER binding peptide (Acetyl-RRRNEQELLELDKWASLWNWFDITNWLWYIRRR-Ttds-Lys-(Biotin)-NH.sub.2) (SEQ ID NO: 284) at 30 L per minute, and binding was detected by measurement of association for 240 seconds, and dissociation for 300 seconds on a Biacore 3000 at 25 C. HBS-EP buffer was used for sample dilution, as well as running buffer. Regenration of the chip was done with 3 M MgCl.sub.2 at 30 L per minute. For data analysis the BIAevaluation software v.4.1 (GE Healthcare) was used. Data were fit globally using a 1:1 Langmuir model with mass transfer. After software-based curve fitting, the ON and OFF reates at each concentration of MPER binding peptide was calculated and used to obtain a binding affinity for each binding protein.

    [0955] The affinity of the indicated proteins for the CD4BS binding site on the HIV-1 protein gp120 was measured by SPR as follows: recombinant HIV-1 gp120 (Thr27-Arg498) protein (HIV-1/Clade B/C (CN54), ARCO Biosystems (Cat. #GP4-V15227)) was captured on a CM5 chip, followed by flow through of varying concentrations (100 nM-6.25 nM) of the binding proteins, and binding was detected by measurement of association for 240 seconds, and dissociation for 300 seconds on a Biacore 3000 at 25 C. HBS-EP buffer was used for sample dilution, as well as running buffer. Regenration of the chip was done with 3 M MgCl.sub.2 at 30 L per minute. For data analysis the BIAevaluation software v.4.1 (GE Healthcare) was used. Data were fit globally using a 1:1 Langmuir model with mass transfer. After software-based curve fitting, the ON and OFF reates at each concentration of Binding Protein was calculated and used to obtain a binding affinity for each binding protein.

    Conformational Stability and Aggregation Assays

    [0956] Conformational stability of the trispecific binding proteins was assessed by determining the melting point T.sub.m and aggregation onset temperature (T.sub.agg).

    [0957] Melting point T.sub.m measurements were performed by differential scanning fluorimetry (DSF). Samples were diluted in D-PBS buffer (Invitrogen) to a final concentration of 0.2 g/L including a 4 concentration solution of SYPRO-Orange dye (Invitrogen, 5000 stock in DMSO) in D-PBS in white sem-skirt 96-well plates (BIORAD). All measurements were done in duplicate using a MyiQ2 real time PCR instrument (BIORAD). Negative first derivative curves (d(RFU)/dT) of the melting curves were generated in the iQ5 software v2.1 (BIORAD). Data were then exported into Excel for T.sub.m determination and graphical display.

    [0958] Melting Point T.sub.m and aggregation onset temperature (T.sub.agg) were also measured by static light scattering (SLS) using a Unit instrument (Unchained Labs). 9 L of each sample was loaded undiluted into a multicuvette array. The samples were then heated from 20 C. to 95 C. at a heating rate of 0.3 C./minute. The barycentric mean (BCM) of the tryptophan fluorescence spectra was used to measure the protein melting curve, and determine the T.sub.m values. The 266 nm static light scattering (SLS) signal was used to measure the aggregation curve and determine the T.sub.agg. Data analysis was performed using the Unit analysis software v2.1.

    Results

    [0959] A novel strategy was developed for improving neutralizing antibody efficacy against HIV-1, while concomitantly limiting the likelihood of viral breakthrough due to high sequence diversity and/or viral mutation. This strategy involved the generation of trispecific binding proteins comprising four polypeptides that formed three antigen binding sites that specifically bind three different epitopes on the HIV Env glycoprotein (FIG. 1). Each antigen binding site comprised the V.sub.H and V.sub.L domain from a different HIV-1 neutralizing antibody that targeted a distinct epitope on the Env glycoprotein. The trispecific binding proteins contained a first pair of polypeptides that possessed dual variable domains having a cross-over orientation forming two distinct antigen binding sites (called the CODV Ig format), and a second pair of polypeptides, each with a single variable domain that formed a third antigen binding site (FIGS. 1A and 1B).

    [0960] The first pair of polypeptides (that possessed the dual variable domains) comprised a first polypeptide having the structure V.sub.L2-Linker-V.sub.L1-Linker-Immunoglobulin light chain constant domain, and a second polypeptide having the structure V.sub.H1-Linker-V.sub.L2-Linker-Immunoglobulin C.sub.H1, hinge, C.sub.H2, and C.sub.H3 heavy chain constant domains, resulting in a pair of polypeptides which had a cross over orienation that formed two distinct antigen binding sites: V.sub.H1-V.sub.L1 and V.sub.H2-V.sub.L2 (FIGS. 1C and 1D, see light and heavy chains B). The second pair of polypeptides (that each posessed a single variable domain) comprised a first polypeptide having the structure V.sub.H3-Immunoglobulin C.sub.H1, hinge, C.sub.H2, and C.sub.H3 heavy chain constant domains, and a second polypeptide having the structure V.sub.L3-Immunoglobulin light chain constant domain, resulting in a pair of polypetpides that formed a third antigen binding site: V.sub.H3-V.sub.L3 (FIGS. 1C and 1D, see light and heavy chains A). In addition, the trispecific binding proteins were constructed to include an LS mutation. Furthermore, the trispecific binding proteins were constructed such that within one binding protein, one C.sub.H3 domain included a knob mutation and the other C.sub.H3 domain included a hole mutation to facilitate heterodimerization of the heavy chains (FIG. 1).

    [0961] Using the above described approach for trivalent binding protein design, three trispecific binding proteins (Binding Proteins 2, 3, and 24) were generated. These trispecific binding proteins were created by grafting onto a trispecific binding protein framework the V.sub.H and V.sub.L domains isolated from antibodies targeting three distinct epitopes on the HIV-1 Env glycoprotein: MPER Ab (targeting the MPER epitope on gp41), CD4BS Ab b (targeting the CD4 Binding Site on gp120), and V1/V2 directed Ab a (targeting the V1/V2 domain on gp120). Binding Protein 2 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the HIV-1 Env glycoprotein epitopes MPER and V1/V2, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 Env glycoprotein epitope CD4BS (Binding Protein 2=MPERV1/V2/CD4BS). Binding Protein 3 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the HIV-1 Env glycoprotein epitopes V1/V2 and MPER, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 Env glycoprotein epitope CD4BS (Binding Protein 3=V1/V2MPER/CD4BS). Binding Protein 24 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the HIV-1 Env glycoprotein epitopes V1/V2 and CD4BS, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 Env glycoprotein epitope MPER (Binding Protein 24=V/V2CD4BS/MPER). The three trispecific binding proteins, as well as their parental antibodies, were purified over protein A affinity resin (FIGS. 2A and 3A) followed by size exclusion chromatography (FIGS. 2B and 3B) to obtain monomeric proteins suitable for further characterization. All three trispecific binding proteins were stable and formed monomers at high frequency.

    [0962] To test the potential for developing binding proteins targeting two different HIV-1 Env protein epitopes (instead of three), bispecific binding proteins were designed based upon the above described CODV Ig format (See WO 2012/135345), using two different V.sub.H and V.sub.L domains from the same parental antibodies used to create the trispecific binding proteins. However, the bispecific binding proteins with these specific variable domains did not purify well as monomers, showing significantly increased aggregate formation when compared to the corresponding trispecific binding proteins (FIGS. 4A and 4B).

    [0963] Next, the binding affinity of the purified trispecific binding proteins (and their parental antibodies) was measured for the HIV-1 Env glycoprotein epitopes on gp41 and gp120. First, the binding affinity for gp41 was measured for the three trispecific binding proteins, as well as the parental MPER antibody, by Biacore assay using the MPER binding peptide (FIG. 5). The binding affinity for the MPER antibody was calculated to be 18.7 nM. Surprisingly, the three trispecific binding proteins all had a higher affinity for the MPER binding peptide than did the parental antibody (Table 3), with Binding Protein 2 having an approximately 3.1 fold higher affinity than the MPER antibody (6.05 nM vs. 18.7 nM, respectively).

    TABLE-US-00001 TABLE 3 Affinity measurements for the MPER binding peptide MW Rmax MPER Antibody Analyte ka (1/Ms) kd (1/s) (RU) KA (1/M) KD (M) Chi2 (kDa) MPER Ab Gp41- 5.85E+04 1.09E03 47.5 5.35E+07 1.87E08 0.55 5.25 MPER JPT Binding Gp41- 1.15E+05 6.97E04 29.0 1.65E+08 6.05E09 0.27 2.29 Protein 2 MPER JPT Binding Gp41- 4.67E+04 7.79E04 38.5 6.00E+07 1.67E08 0.41 5.14 Protein 3 MPER JPT Binding Gp41- 6.28E+04 8.06E04 35.5 7.80E+07 1.28E08 0.48 5.24 Protein 24 MPER JPT

    [0964] Similarly, the binding affinity for the CD4 Binding Site on gp120 was measured for the three trispecific binding proteins, as well as the parental CD4BS antibody, by Biacore assay (FIG. 6). The three trispecific binding proteins all had a similar affinity for the CD4 Binding Site when compared to the parental antibody (Table 4).

    TABLE-US-00002 TABLE 4 Affinity measurements for the CD4BS binding site Antibody ka (1/Ms) kd (1/s) Rmax (RU) KD (M) Chi2 CD4BS 2.79E+05 2.32E04 31.4 8.30E10 1.17 Ab b Binding 2.31E+05 2.41E04 34.0 1.04E09 0.74 Protein 2 Binding 7.58E+04 2.75E04 38.2 3.63E09 0.19 Protein 3 Binding 1.46E+05 2.52E04 41.6 1.73E09 0.38 Protein 24

    [0965] Thus, the trispecific binding proteins were able to bind both of the tested target epitopes on the HIV-1 Env glycoprotein (Table 5). Moreover, all three trispecific binding proteins bound the target epitopes with affinities approximately equal to or exceeding those of their parental antibodies. Binding affinity of the V1/V2 directed Ab a, as well as of the V1/V2 directed Ab a binding sites within the three trispecific binding proteins 2, 3, and 24 could not be determined by Biacore analysis because this required a specific gp120 protein antigen which was unavailable.

    TABLE-US-00003 TABLE 5 Summary of binding capabilities of tested binding proteins Sample Binding on gp120? Binding on gp41? MPER Ab No Yes CD4BS Ab b Yes No V1/V2 directed Ab a No No Binding Protein 2 Yes Yes Binding Protein 3 Yes Yes Binding Protein 24 Yes Yes

    [0966] The biophysical properties were tested for the trispecific binding proteins and parental antibodies (Table 6). All of the tested proteins had similar stabilities and limited propensities to form aggregates.

    TABLE-US-00004 TABLE 6 Conformational stability/aggregation of the binding proteins DSF Intrinsic AA SLS at 266 Sample T.sub.m ( C.) Fluo T.sub.m ( C.) nm T.sub.agg ( C.) MPER Ab 69/75 68 71 CD4BS Ab b 69 66 68 V1/V2 directed Ab a 69 64 67 Binding Protein 2 60/70 54 58 Binding Protein 3 57/70 55 56 Binding Protein 24 56/71 53 54

    [0967] These experiments indicated that stable, monomeric, trispecific binding proteins targeting three distinct epitopes on the HIV-1 Env glycoprotein could be constructed and efficiently purified. Furthermore, the trispecific binding proteins retained their ability to bind their target epitopes, having similar or improved affinity relative to their parental antibodies. Finally, the trispecific binding proteins had suitable biophysical properties, and showed significantly less aggregation than the corresponding bispecific binding proteins.

    Example 2: Characterization of the Binding Proteins

    [0968] Due to the success of developing three trispecific binding proteins with appropriate biophysical properties and binding abilities (as described in Example 1), 21 additional trispecific binding proteins were developed and tested. The experiments described herein explored the ability of the 24 trispecific binding proteins to neutralize HIV-1 in vitro, and the pharmacokinetic properties of a number of these trispecific binding proteins in vivo.

    [0969] Neutralization assays were performed using the TZM-bl assay which measures neutralization as a function of reductions in HIV-1 Tat-regulated firefly luciferase (Luc) reporter gene expression after a single round of infection with Env-pseudotyped viruses. The assays were performed as described in Marcella Sarzotti-Kelsoe et al., J. Immunological Methods, 409:131-146 (2014). The neutralization results of various antibodies are shown in Tables 8-10.

    Methods

    Production of Env-Pseudotyped Viruses

    [0970] Assay stocks of Env-pseudotyped viruses were produced in 293T/17 cells by co-transfection with two plasmids: an Env expression plasmid and a plasmid expressing the entire HIV-1 genome except for Env. Co-transfection of these plasmids produced infectious pseudovirus particles which were capable of delivering the Tat gene into target cells, but infections with these pseudovirions could not themselves produce infectious viral progeny.

    Viral Neutralization Assay

    [0971] Neutralization of HIV infection using TZM-bl cells (also known as JC53BL-13 cells) was performed as described previously (Marcella Sarzotti-Kelsoe et al., J. Immunological Methods, 409:131-146 (2014)). Briefly, a single round of infection using the Env-pseudotyped HIV-1 virions was carried out in TZM-bl cells (a CXCR-4-positivie HeLa cell clone). TZM-bl cells were engineered to express CD4 and CCR5, and to contain integrated reporter genes for firefly luciferase and E. coli 0-galactosidase under the control of an HIV long-terminal repeat. Reporter gene expression was induced in trans by viral Tat protein (delivered by the pseudotyped viruses) soon after single cycle infection. Luciferase activity was quantified as relative luminescence units (RLU), and was directly proportional to the number of infectious virus particles present in the initial inoculum over a wide range of values. Neutralization was measured as a function of decreased Tat-regulated Firefly luciferase (Luc) reporter gene expression after administration of varying concentrations of the indicated binding proteins. Neutralization titers were identified as the protein dilution at which RLUs were reduced by 80% compared to virus control wells after subtraction of background RLUs. The assay was performed in 96-well plates for high throughput capacity, and well-characterized reference strains were utilized for uniformity across studies.

    Pharmacokinetic (PK) Measurements

    [0972] Female Indian rhesus macaques weighing between 3 and 6 kg were randomly assigned to groups according to body weight (two macaques per group) and were intravenously injected with the indicated concentration of binding proteins. Blood was collected from the animals before the injection on day 0, and 30 minutes, 6 hours, 1 day, 2 days, 4 days, 7 days, 14 days, 21 days and 28 days after injection. The serum concentration of each binding protein was quantified in the plasma from the collected blood using an RSC3-based ELISA assay.

    Results

    [0973] 21 additional trispecific binding proteins targeting three distinct HIV-1 Env glycoprotein epitopes were generated and purified as described in Example 1. These 21 additional trispecific binding proteins (Binding Proteins 1 and 4-23) were created by grafting onto a trispecific binding protein framework the V.sub.H and V.sub.L domains isolated from antibodies targeting distinct HIV-1 epitopes on the HIV-1 Env glycoprotein: the anti-MPER antibodies MPER Ab a and MPER Ab b (targeting the MPER epitope on gp41), the anti-CD4BS antibodies (CD4BS Ab a and CD4BS Ab b (targeting the CD4 Binding Site on gp120), the anti-V1/V2 antibodies V1/V2 directed Ab a and V1/V2 directed Ab b (targeting the V1/V2 domain on gp120), and the anti-V3 antibody V3 directed Ab (targeting the V3 loop on gp120) (Table 7).

    TABLE-US-00005 TABLE 7 Epitope binding site composition of the trispecific binding proteins Binding Protein: Epitope Binding Site: 1 MPER V1/V2 directed/CD4BS 2 MPER V1/V2 directed/CD4BS 3 V1/V2 directed MPER/CD4BS 4 MPER V1/V2 directed/CD4BS 5 MPER V3 directed/CD4BS 6 V1/V2 directed MPER/CD4BS 7 V3 directed V1/V2 directed/CD4BS 8 MPER V1/V2 directed/CD4BS 9 MPER V1/V2 directed/CD4BS 10 V1/V2 directed MPER/CD4BS 11 MPER V1/V2 directed/CD4BS 12 MPER V3 directed/CD4BS 13 MPER V3 directed/V1/V2 directed 14 V1/V2 directed MPER/CD4BS 15 MPER V3 directed/V1/V2 directed 16 MPER V3 directed/CD4BS 17 V1/V2 directed V3 directed/CD4BS 18 V3 directed MPER/CD4BS 19 V3 directed V1/V2 directed/MPER 20 V3 directed V1/V2 directed/CD4BS 21 MPER CD4BS/V1/V2 directed 22 CD4BS MPER/V1/V2 directed 23 CD4BS V1/V2 directed/MPER 24 V1/V2 directed CD4BS/MPER

    [0974] The viral neutralization capabilities of five of the trispecific binding proteins (and their parental antibodies) at varying concentrations were tested against a panel of 208 different HIV-1 Env-pseudotyped viruses (Table 8). Binding protein-mediated neutralization of the pseudotyped HIV-1 isolates was measured using the TZM-bl luciferase reporter gene assay. The inhibitory dose for each binding protein was calculated for each pseudotyped virus as the dilution that caused an 80% reduction in luminescence (IC.sub.80) after infection. Surprisingly, the IC.sub.80 geometric means calculated for each of the tested trispecific binding proteins was lower than the parental antibodies, suggesting that these trispecific binding proteins were more potent at neutralizing pseudotyped HIV-1 than their parental neutralizing antibodies.

    TABLE-US-00006 TABLE 8 IC.sub.80 measurements from viral neutralization assay Parental Antibody: V1/V2 V3 Binding Protein: MPER directed directed CD4BS CD4BS 15 1 2 19 20 3 Ab Ab a Ab Ab b Ab a # Viruses 208 208 208 208 208 208 208 208 208 208 208 Total VS Neutralized: IC.sub.80 < 50 g/ml 190 202 206 198 206 206 203 151 113 202 183 IC.sub.80 < 10 g/mL 180 199 206 180 206 206 193 149 109 200 175 IC.sub.80 < 1.0 g/mL 166 169 191 145 188 186 61 133 98 184 108 IC.sub.80 < 0.1 g/mL 122 109 136 80 144 123 10 99 72 79 10 IC.sub.80 < 0.01 g/mL 74 7 70 22 54 47 5 24 26 6 0 % VS Neutralized: IC.sub.80 < 50 g/mL 91 97 99 95 99 99 98 73 54 97 88 IC.sub.80 < 10 g/mL 87 96 99 87 99 99 93 72 52 96 84 IC.sub.80 < 1.0 g/mL 80 81 92 70 90 89 29 64 47 88 52 IC.sub.80 < 0.1 g/mL 59 52 65 38 69 59 5 48 35 38 5 IC.sub.80 < 0.01 g/mL 36 3 34 11 26 23 2 12 13 3 0 Median IC.sub.80 0.033 0.088 0.026 0.164 0.029 0.045 1.69 0.037 0.054 0.149 0.780 Geometric Mean 0.033 0.135 0.028 0.199 0.034 0.051 1.34 0.063 0.057 0.144 0.814

    [0975] Next, the viral neutralization capabilities of a larger panel of trispecific binding proteins (and their parental antibodies) at varying concentrations were tested against 20 pseudotyped viruses representing 10 different HIV-1 clades (Table 9). The trispecific binding proteins provided robust protection against infection with these 20 viruses (Table 10).

    TABLE-US-00007 TABLE 9 20 representative viruses used for viral neutralization assay Virus Clade KER2008.12.SG3 A 620345.c1.SG3 AE DJ263.8.SG3 AG T266-60.SG3 AG T278-50.SG3 AG BL01.DG.SG3 B BR07.DG.SG3 B CNE57.SG3 B H086.8.SG3 B QH0692.42.SG3 B SS1196.01.SG3 B CNE21.SG3 BC 6471.V1.C16.SG3 C CAP210.E8.SG3 C DU156.12.SG3 C DU422.01.SG3 C TV1.29.SG3 C ZM106.9.SG3 C 3817.v2.c59.SG3 CD X2088.c9.SG3 G

    TABLE-US-00008 TABLE 10 IC.sub.80 measurements from viral neutralization assay of 20 representative viruses Total VS Neutralized % VS Neutralized IC.sub.80 < 50 IC.sub.80 < 1 IC.sub.80 < 50 IC.sub.80 < 1 Median Geometric # Viruses g/mL g/mL g/mL g/mL IC.sub.80 Mean Binding Protein 4 20 17 11 85 55 0.474 0.398 Binding Protein 5 20 14 11 70 55 0.199 0.324 Binding Protein 6 20 16 9 80 45 0.453 0.449 Binding Protein 7 20 16 9 80 45 0.523 0.312 Binding Protein 8 20 17 12 85 60 0.578 0.488 Binding Protein 9 20 14 9 70 45 0.836 0.531 Binding Protein 10 20 16 12 80 60 0.222 0.173 Binding Protein 11 20 18 15 90 75 0.310 0.181 Binding Protein 12 20 17 12 85 60 0.526 0.566 Binding Protein 13 20 19 12 95 60 0.202 0.189 Binding Protein 14 20 17 15 85 75 0.208 0.088 Binding Protein 15 20 17 10 85 50 0.345 0.378 Binding Protein 16 20 18 11 90 55 0.228 0.314 Binding Protein 17 20 17 12 85 60 0.086 0.180 Binding Protein 18 20 15 10 75 50 0.536 0.501 Binding Protein 19 20 18 11 90 55 0.563 0.538 Binding Protein 20 20 18 14 90 70 0.224 0.229 Binding Protein 21 20 15 9 75 45 0.627 0.501 Binding Protein 2 20 18 13 90 65 0.375 0.222 Binding Protein 22 20 13 8 65 40 0.856 0.634 Binding Protein 23 20 17 6 85 30 1.930 1.129 Binding Protein 3 20 18 12 90 60 0.469 0.287 Binding Protein 24 20 16 7 80 35 2.130 1.054 MPER Ab a 20 16 8 80 40 1.007 0.981 MPER Ab b 20 16 16 80 80 0.071 0.024 CD4BS Ab b 20 15 9 75 45 0.181 0.399 V1/V2 directed Ab a 20 11 9 55 45 0.060 0.094 V3 directed Ab 20 12 10 60 50 0.183 0.136 CD4BS Ab a 20 10 1 50 5 1.530 1.811 V1/V2 directed Ab b 20 9 9 45 45 0.051 0.039

    [0976] Finally, the pharmacokinetics (PK) of a subset of the trispecific binding proteins and parental antibodies were tested in rhesus macaques. Briefly, 10 or 20 mg/kg of the proteins were intravenously injected into female rhesus macaques, and ELISA assays were performed on the plasma from blood samples taken prior to injection, and on the plasma from blood samples taken at many time points after the injection (up to 42 days) (FIG. 7). All of the trispecific binding proteins could be detected at least 14 day after IV administration, with Binding Protein 1 remaining detectable at least 35 days after injection, showing that the binding proteins were stable in vivo.

    [0977] Taken together, this data suggested that broadly neutralizing trispecific binding proteins could be constructed which targeted three distinct epitopes on the HIV-1 Env glycoprotein. These binding proteins showed similar or increased potency/much improved neutralizing capabilities (breadth) relative to the parental neutralizing antibodies. Furthermore, these trispecific binding proteins appeared to be well tolerated in vivo. Without wishing to be bound by theory, the development of broadly neutralizing trispecific binding proteins targeting multiple epitopes on HIV may allow for improved anti-viral therapy relative to monospecific or bispecific antibodies, as HIV viral particles are less likely to be resistant to all three antigen binding sites on the neutralizing trispecific binding proteins than the single or dual antigen binding sites on monospecific or bispecific neutralizing antibodies, respectively.

    Example 3: Characterization of T-Cell Engagers

    [0978] As noted above, Env is expressed on the surface of HIV-infected cells. Because of this, Env can act as an antibody target to identify infected cells, and induce Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement Dependent Cytotoxicity (CDC), resulting in reduction of the latent viral reservoir. The studies described herein explore the development of novel trispecific binding proteins (termed T cell engagers) that contain three antigen binding sites targeting three different antigens (HIV-1 Env glycoprotein, CD3, and CD28). These novel proteins not only include antigen binding sites from neutralizing antibodies, but also the ability to bind effector T cells, bringing them into close proximity to infected target cells, thus inducing HIV-infected cell lysis.

    Methods

    Binding Properties of T-Cell Engagers

    [0979] The binding properties of the T-cell engagers was measured by ELISA assay using a horse radish peroxidase-conjugated anti-Fab probe to detect T-cell engager binding to the surface of ELISA plates coated with CD3. CD28, or Resurfaced Stabilized Core 3 (RSC3) protein of gp120. Human CD3ge-hIgG4 (KIH) (Cat. No: 03-01-0051) from Cambridge Biologics, MA, USA; Human CD28-hIgG4 (Cat. No: 03-01-0303) from Cambridge Biologics, MA, USA.

    T-Cell Activation Assay

    [0980] CD4 and CD8 T cell activation were measured as follows: peripheral blood mononuclear cells (PBMCs) were enriched from buffy coats obtained from nave donors (NIH blood bank) using magnetic beads (Miltenyi Biotec). These cells were co-cultured for 14-16 hours with either uninfected or HIV-1 infected CEM cells in the presence of increasing concentrations of the binding proteins (0.01-1.0 g/mL) with brefeldin A. The cells were then stained for surface expression of T-cell markers (CD3, CD4, and CD8) and activation markers (CD25 and CD69), followed by intracellular staining for cytokines (IFN-, TNF-, and IL-2) using fluorescently conjugated antibodies (BD Biosciences, eBiosciences. Biolegend). The number of CD4 and CD8 T cells expressing each cytokine or activation marker was determined by running the samples on an LSRII flow cytometer and analyzing the data with Flonjo software (Treeestar).

    CD3 Downregulation

    [0981] CD3 downregulation after T cell activation by the T-cell engagers was measured by staining activated PBMCs with non-competing mouse anti-human CD3 antibody and quantitated using flow cytometry.

    Cytotoxicity Assay

    [0982] Cytotoxicity of the T-cell engagers to CEM-BaL, ACH2, and J1.1 cells was monitored by flow cytometry as follows: latent cell lines (ACH2, J1.1, OM10) were obtained from the NIH AIDS Reagent Program. The activation of these cells was performed by culturing the cells in the presence or absence of TNF- (10 ng/mL) for 14-16 hours. Activation was measured by determining the expression of cell surface HIV envelope glycoprotein by flow cytometry using an allophycocyanin-conjugated anti-HIV Env antibody (2G12). The CEM-IIIb, ACH2, J1.1 and OM10 cells were labeled with the membrane dye PKH-26 (Sigma) and used as target cells in a cytotoxicity assay. These labeled target cells were co-cultured for 14-16 hours at an E:T ratio of 10:1 with enriched human T cells as effector cells in the presence of increasing amounts of the binding proteins. The extent of cell lysis in the target cells was determined by staining with a live/dead cell marker (Life technologies) and measuring the number of dead cells in the labeled target cell population by running the samples on an LSRII flow cytometer followed by analysis using Flowjo software (Treestar).

    Results

    [0983] The capacity to develop T cell engagers with antigen binding sites targeting both T cell surface proteins and neutralizing epitopes on HIV-1 was explored. T cell engagers were constructed which contained two antigen binding sites targeting two different T cell surface receptors (CD3 and CD28), and a third antigen binding site targeting the HIV-1 Env glycoprotein (FIGS. 8A and 8B). In addition, the T cell engagers were constructed to include an LS mutation. Furthermore, the T cell engagers were constructed such that within one binding protein, one C.sub.H3 domain included a knob mutation and the other C.sub.H3 domain included a hole mutation to facilitate heterodimerization of the heavy chains (FIGS. 8A and 8B).

    [0984] Using this approach, two T cell engagers were constructed which targeted both T cell surface proteins and the HIV-1 Env glycoprotein (Binding Protein 32 and CD3CD28/CD4BS b Ab). These two T cell engagers were created by grafting onto a trispecific binding protein framework the V.sub.H and V.sub.L domains isolated from parental antibodies targeting the T cell surface proteins CD3 and CD28, and the anti-HIV-1 antibody CD4BS Ab b (targeting the CD4 Binding Site on gp120). Binding Protein 32 was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the T cell surface receptors CD28 and CD3, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 antigen CD4BS (Binding Protein 32=CD28CD3/CD4BS). The CD3CD28/CD4BS b Ab trispecific binding protein was constructed such that the first pair of polypeptides (which formed two antigen binding sites) targeted the T cell surface receptors CD3 and CD28, and the second pair of polypeptides (which formed the single antigen binding site) targeted the HIV-1 antigen CD4BS (Table 11).

    TABLE-US-00009 TABLE 11 Format of T-cell engagers Arm 1 Arm 2 Arm 3 Format Name of Construct Antigen Antigen Antigen T cell engagers, CD3 CD28/CD4BS CD4BS CD3 CD28 trispecific Ab b T cell engagers, Binding Protein 32 CD4BS CD28 CD3 trispecific Monospecific CD4BS IgG4 CD4BS CD4BS

    [0985] The ability of the two T cell engagers to bind to each of their three target antigens was tested by ELISA assay. The T cell engagers were capable of binding both the CD3 and CD28 T cell surface proteins with the CD3 and CD28 antigen binding sites in either orientation in the bispecific arms of the T cell engagers (i.e., CD3CD28 for CD3CD28/CD4BS Ab b or CD28CD3 for Binding Protein 32). Both T cell engagers were also capable of binding to gp120 (as measured using the HIV-1 RSC3 protein, a gp120 variant lacking the V1, V2, and V3 variable regions) (FIG. 9).

    [0986] The effect on T cell activity was next tested for both of the T cell engagers. Incubation of the T cell engagers with monocytes revealed that the T cell engagers induced robust CD8.sup.+ T cell activation (FIG. 10). Similarly, the T cell engagers were capable of inducing significant CD4.sup.+ T cell activation on PBMCs alone, or PBMCs incubated with either of the HIV-1 infected T cell lines CEM-NKr cells or CEM-BaL cells (FIG. 11). Additionally, both of the T cell engagers reduced cell surface expression of CD3 on activated T cells (FIG. 12).

    [0987] Finally, the ability of the T cell engagers to induce lysis of HIV-infected cells was tested. The T cell engagers (and positive and negative control bispecific binding proteins targeting CD3 and an HIV antigen) were incubated with the HIV-1 infected T cell line CEM-BaL cells. Incubation of the T cell engagers with the infected cells induced robust cell lysis over a wide range of concentrations (FIG. 13A). Likewise, incubation of these T cell engagers induced lysis of the latently infected T cell line ACH2 cells (FIG. 13B), as well as J1.1 cells (FIG. 13C). Surprisingly, the T cell engagers showed comparable or better cytotoxic activity against chronic and latent HIV-infected cell lines when compared to the bispecific binding proteins.

    [0988] Taken together, the novel T cell engagers described herein retained the ability from their parental antibodies to bind their target antigens on the HIV-1 Env glycoprotein gp120 on HIV-infected cells, as well as the cell-surface exposed T cell proteins CD3 and CD28. The T cell engagers induced robust CD4.sup.+ and CD8.sup.+ T cell activation, and diminished CD3 surface expression. Finally, these T cell engagers induced significant lysis of HIV-1 infected T cells. Without wishing to be bound by theory, these T cell engagers may provide a novel strategy for anti-viral therapeutics by reducing/eliminating the latent viral reservoir through T cell engagement in HIV/AIDS patients.

    [0989] While the present disclosure includes various embodiments, it is understood that variations and modifications will occur to those skilled in the art. Therefore, it is intended that the appended claims cover all such equivalent variations that come within the scope of the disclosure. In addition, the section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

    [0990] Each embodiment herein described may be combined with any other embodiment or embodiments unless clearly indicated to the contrary. In particular, any feature or embodiment indicated as being preferred or advantageous may be combined with any other feature or features or embodiment or embodiments indicated as being preferred or advantageous, unless clearly indicated to the contrary.

    [0991] All references cited in this application are expressly incorporated by reference herein.

    SEQUENCES

    TABLE-US-00010 TABLE 1 Heavy and light chain SEQ ID NOs for binding proteins 1-53 and the target antigens to which the binding proteins are directed. Binding Protein SEQ ID NOs Target 1 4, 3, 1, 2 MPER V1/V2 directed/CD4BS 2 12, 11, 9, 10 MPER V1/V2 directed/CD4BS 3 20, 19, 17, 18 V1/V2 directed MPER/CD4BS 4 28, 27, 25, 26 MPER V1/V2 directed/CD4BS 5 36, 35, 33, 34 MPER V3 directed/CD4BS 6 44, 43, 41, 42 V1/V2 directed MPER/CD4BS 7 52, 51, 49, 50 V3 directed V1/V2 directed/CD4BS 8 60, 59, 57, 58 MPER V1/V2 directed/CD4BS 9 68, 67, 65, 66 MPER V1/V2 directed/CD4BS 10 76, 75, 73, 74 V1/V2 directed MPER/CD4BS 11 84, 83, 81, 82 MPER V1/V2 directed/CD4BS 12 92, 91, 89, 90 MPER V3 directed/CD4BS 13 100, 99, 97, 98 MPER V3 directed/V1/V2 directed 14 108, 107, 105, 106 V1/V2 directed MPER/CD4BS 15 116, 115, 113, 114 MPER V3 directed/V1/V2 directed 16 124, 123, 121, 122 MPER V3 directed/CD4BS 17 132, 131, 129, 130 V1/V2 directed V3 directed/CD4BS 18 140, 139, 137, 138 V3 directed MPER/CD4BS 19 148, 147, 145, 146 V3 directed V1/V2 directed/MPER 20 156, 155, 153, 154 V3 directed V1/V2 directed/CD4BS 21 164, 163, 161, 162 MPER CD4BS/V1/V2 directed 22 172, 171, 169, 170 CD4BS MPER/V1/V2 directed 23 180, 179, 177, 178 CD4BS V1/V2 directed/MPER 24 188, 187, 185, 186 V1/V2 directed CD4BS/MPER 25 196, 195, 193, 194 MPER V1/V2 directed/CD4BS 26 204, 203, 201, 202 MPER V1/V2 directed/CD4BS 27 212, 211, 209, 210 MPER V1/V2 directed/CD4BS 28 220, 219, 217, 218 MPER V1/V2 directed/CD4BS 29 228, 227, 225, 226 MPER V1/V2 directed/CD4BS 30 235, 234, 232, 233 MPER V1/V2 directed/CD4BS 31 243, 242, 240, 241 MPER V1/V2 directed/CD4BS 32 305, 304, 302, 303 CD28 CD3/CD4BS 33 313, 312, 310, 311 CD28 CD3/CD4BS 34 321, 320, 318, 319 CD28 CD3/V1/V2 directed 35 329, 328, 326, 327 CD28 CD3/V1/V2 directed 36 337, 336, 334, 335 CD28 CD3/CD4BS 37 345, 344, 342, 343 CD28 CD3/CD4BS 38 353, 352, 350, 351 CD4BS CD3/CD28 39 361, 360, 358, 359 CD4BS CD3/CD28 40 369, 368, 366, 367 CD3 CD4BS/CD28 41 377, 376, 374, 375 CD3 CD4BS/CD28 42 385, 384, 382, 383 CD4BS CD3/CD28 43 393, 392, 390, 391 CD4BS CD3/CD28 44 401, 400, 398, 399 CD3 CD4BS/CD28 45 409, 408, 406, 407 CD3 CD4BS/CD28 46 417, 416, 414, 415 V1/V2 directed CD3/CD28 47 425, 424, 422, 423 V1/V2 directed CD3/CD28 48 433, 432, 430, 431 CD3 V1/V2 directed/CD28 49 441, 440, 438, 439 CD3 V1/V2 directed/CD28 50 449, 448, 446, 447 V1/V2 directed CD3/CD28 51 457, 456, 454, 455 V1/V2 directed CD3/CD28 52 465, 464, 462, 463 CD3 V1/V2 directed/CD28 53 473, 472, 470, 471 CD3 V1/V2 directed/CD28

    TABLE-US-00011 TABLE2 Heavyandlightchainsequencesofbindingproteins.CDRsequencesare boldedanditalicized. BindingProtein1AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk SEQIDNO:1 prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgyhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqvnstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh ytqkslslspg LightchainA Eivltqspgtlslspgctaiiscrtsqygslawyqqrpgqaprlviysgstraagipd SEQIDNO:2 rfsgsrwgpdynltisnlesgdfgvyycqqveffgqgtkvqvdikrtvaapsyfif ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdst yslsstltlskadyekhkvyacevthqglsspytksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritg SEQIDNO:3 pgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfw sgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrkpgtsvkvsckapg ntlktydlhwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstnta ylqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwgq gtavtvssdkthtastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe vkfnwyvdgvevhnaktkpreepqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave wesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhsh ytqkslslspg LightchainB Dfvltqsphslsvtpgesasiscksshslikgdrnnylawyvqkpgrspqlliyla SEQIDNO:4 ssrasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik dktht aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrps gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkth trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes vteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein1NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc SEQIDNO:5 ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc cctctggcccctagcagcaagagcacatctggcggaacagcgccctgggctgcct cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct gctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgagcctg agccccggc LightchainA Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag SEQIDNO:6 ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO:7 cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc cctgtacgacgatgacgggccctgaactgggccgtggatgtggactacctgagca acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt gacggtgtgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa tgccaagacaaagccggggaggagcagtacaacagcacgtaccgtgtggtcagc gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca ctacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO:8 ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacge ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg gcgagtgt BindingProtein2AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO:9 ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswald awgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlgssglyslssvvtvpssslgtqtyicnynhkpsntkydkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvydvshedpe vkfnwyydgvevhnaktkpreegynstvrvvsvltvlhqdwlngkeykckysn kalpapiektiskakggprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshyt qkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 10 sdeqlksgtasyycllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 11 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrk pgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviv erfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyddd galnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskst sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn aktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektis kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshyt qkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass SEQIDNO: rasgypdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 12 kthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnr psgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldk thtrtvaapsvfifppsdeqlksgtasvvclinnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein2NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 13 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag cctgagccccggc LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt SEQIDNO: gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 14 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga tggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 15 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa tgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagc gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag gtggcagcaggggaacgtcttctcatgctccgtgtgcatgaggctctgcacagcca ctacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 16 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg gcgagtgt BindingProtein3AminoAcidSequences HeavychainA rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpqy SEQIDNO: gavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswalda 17 wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsg altsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk scdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpev kfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnk alpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewe sngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshytq kslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 18 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwm SEQIDNO: gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 19 skhrlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtevrl vesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritg pgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgky ydfwsgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfplapsskst sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn aktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektis kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshyt qkslslspg LightchainB aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg SEQIDNO: ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtd 20 fvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdk thtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvtcgdskdstyslsstltlskadyekhkvyacevthqglsspytksfnrgec BindingProtein3NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 21 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagtgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag cctgagccccggc LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt SEQIDNO: gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 22 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga tgggtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctc SEQIDNO: tgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctg 23 cactgggtgcgcagcgtgccaggacagggactgcagtggatgggctggat cagccacgagggcgacaagaaagtgatcgtggaacggttcaaggccaaag tgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagcg gcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagc accggctgagagactacgccctgtacgacgatgacggcgccctgaactgg gccgtggatgtggactacctgagcaacctggaattctggggccagggcaca gccgtgaccgtgtcatctgacaaaacccataccgaggttagactggtggagt caggaggggggcttgtgaagcccggtgggtctctccgcctgagctgttctgc ctccggctttgatttcgataacgcctggatgacctgggtcaggcagcctccag gtaagggactggagtggggggaagaatcacaggtccaggcgagggctgg tccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaa taccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccg gatattacttctgtgccagaacaggcaaatactacgacttctggtccggctatc cccctggcgaggaatattttcaagactggggtcagggaacccttgttatcgtgt cctccgataagacccacaccgcttccaccaagggcccatcggtcttccccct ggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcct ggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgc cctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactct actccctcagcagcgtggtgaccgtgcccccagcagcttgggcacccaga cctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaaga aagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagc acctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacg tgagccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtgga ggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgt accgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaa ggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaa aaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccct gcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcct ggtaaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgg gcagccggagaacaactacaagaccacgcctcccgtgctggactccgacg gctccttcttcctctactcaaaactcaccgtggacaagagcaggtggcagcag gggaacgtcttctcatgctccgtgctgcatgaggctctgcacagccactacac gcagaagagcctctccctgtctccgggt LightchainB gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgact SEQIDNO: attacttgccgaggcgactcactgcggagccactacgcttcctggtatcagaagaaa 24 cccggccaggcacctgtgctgctgttctacggaaagaacaataggccatctggcatc cccgaccgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggc gcccaggctgaggacgaagccgattactattgcagctcccgggataagagcggctc cagactgagcgtgttcggaggaggaactaaactgaccgtcctcgacaaaacccata ccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagc gccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaact acctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctgg ccagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaa ggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactact gtatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacat caaggataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacct agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttc tacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggc aacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcct gcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgggg cgagtgt BindingProtein4AminoAcidSequences HeavychainA qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk SEQIDNO: prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 25 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealh nhytqkslslspg LightchainA Eivltqspgtlslspgctaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr SEQIDNO: fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 26 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkyyacevthgglsspvtksfnrgec HeavychainB evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 27 rtgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevr kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss vvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapell ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapie ktiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewes ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmheal hnhytqkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas SEQIDNO: srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 28 dkthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkn nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein4NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc SEQIDNO: ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 29 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg agccccggc LightchainA Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag SEQIDNO: ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 30 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 31 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa acccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggc acctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctg cactgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcc acgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcga ctgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggc gataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagc aacctggaattctggggccagggcacagccgtgaccgtgtcatctgataagaccca caccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcac ctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccgg tgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcag cgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaagg tctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca ctacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 32 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg gcgagtgt BindingProtein5AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk SEQIDNO: prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 33 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh ytqkslslspg LightchainA Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr SEQIDNO: fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkyqvdikrtvaapsvfifp 34 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 35 tgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpglv kpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnyspsl ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty fymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns tyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqv ytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvl dsdgsfflyskltvdksrwqggnvfscsvmhealhnhytqkslslspg LightchainB Sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsg SEQIDNO: spdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtaselt 36 qdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein5NucleotideSequences HeavychainA Caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatg SEQIDNO: cggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggat 37 cagactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggc ggagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggac gtgtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgcc gtgtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactgg ggcagaggcacccctgtgatcgtgtcaagc gcgtcgaccaagggccccagcgtgttccctctggcccctagcagcaagagcacatc tggcggaacagccgccctgggctgcctcgtgaaggactactttcccgagcccgtga ccgtgtcctggaattctggcgccctgaccagcggcgtgcacacctttccagctgtgct gcagtccagcggcctgtacagcctgagcagcgtcgtgacagtgcccagcagctctc tgggcacccagacctacatctgcaacgtgaaccacaagcccagcaacaccaaggt ggacaagaaggtggaacccaagagctgcgacaagacccacacctgtcccccttgt cctgcccccgaactgctgggaggcccttccgtgttcctgttccccccaaagcccaag gacaccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtc ccacgaggaccctgaagtgaagttcaattggtacgtggacggcgtggaagtgcaca acgccaagaccaagccaagagaggaacagtacaacagcacctaccgggtggtgtc cgtgctgaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaag gtgtccaacaaggccctgcctgcccccatcgagaaaaccatcagcaaggccaagg gccagccccgcgaaccccaggtgtgcacactgcccccaagcagggacgagctga ccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccctccgatatcg ccgtggaatgggagagcaacggccagcccgagaacaactacaagaccacccccc ctgtgctggacagcgacggctcattcttcctggtgtccaagctgacagtggacaagtc ccggtggcagcagggcaacgtgttcagctgctccgtgatgcacgaggccctgcaca accactacacccagaagtccctgagcctgagccccggc LightchainA Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag SEQIDNO: ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 38 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 39 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa acccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcg agaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactg gagctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcac aagagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccct ggacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgac agcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgt ggccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcaccca ggtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtctt ccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgc ctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccct gaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctc agcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaa cgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatctt gtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggacc gtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccct gaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaa ctggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggag cagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactg gctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagccccca tcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacac cctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggt aaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctct actcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgc tccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctc cgggt LightchainB tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcgagaaga SEQIDNO: gcctgggaagcagggctgtgcagtggtaccaacacagggccggacaggctccca 40 gcctgatcatctacaacaaccaggacaggcccagcggcatccctgagaggttcagc ggaagccccgacagccccttcggaaccacagccaccctgaccatcacaagcgtgg aagccggcgacgaggccgactactactgccacatctgggacagcagggtgcccac caagtgggtgtttggcggcggcaccaccctgaccgtgctggacaaaacccataccg catccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgactat tacttgccgaggcgactcactgcggagccactacgcttcctggtatcagaagaaacc cggccaggcacctgtgctgctgttctacggaaagaacaataggccatctggcatccc cgaccgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc ccaggctgaggacgaagccgattactattgcagctcccgggataagagcggctcca gactgagcgtgttcggaggaggaactaaactgaccgtcctcgataagacccatacc cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaag tccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaa gtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgtg accgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagg gcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein6AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk SEQIDNO: prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 41 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh ytqkslslspg LightchainA Eivltqspgtlslspgctaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr SEQIDNO: fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 42 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwm SEQIDNO: gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 43 skhrlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtevrl vesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritg pgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgky ydfwwgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfplapsskst sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn aktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektis kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhy tqksislspg LightchainB Aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrps SEQIDNO: gipdrfsgsasgnrasltitgaqecdeadyycssrdksgsrlsvfgggtkltvldktht 44 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd kthtrtvaapsvfifppsdeqlksgtasvvcllanfypreakvqwkvdnalqsgns qesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein6NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc SEQIDNO: ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 45 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg agccccggc LightchainA gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag SEQIDNO: ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 46 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga SEQIDNO: aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 47 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg aattctggggccagggcacagccgtgaccgtgtcatctgacaaaacccataccgag gttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcct gagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggct ggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaata ccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatatta cttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctggcga ggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgataagaccc acaccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagca cctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccg gtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggc tgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcag cgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaagg tctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag gtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaacca ctacacgcagaagagcctctccctgtctccgggt LightchainB Gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagact SEQIDNO: gtgactattacttgccgaggcgactcactgcggagccactacgcttcctggta 48 tcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaat aggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgag ccagtctgaccattaccggcgcccaggctgaggacgaagccgattactattg cagctcccgggataagagcggctccagactgagcgtgttcggaggaggaa ctaaactgaccgtcctcgacaaaacccataccgacttcgtgctgacccagag ccctcacagcctgagcgtgacacctggcgagagcgccagcatcagctgca agagcagccactccctgatccacggcgaccggaacaactacctggcttggt acgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctac tactgtatgcagggcagagagagcccctggacctttggccagggcaccaag gtggacatcaaggataagacccataccgtacggtggccgctcccagcgtg ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgt gtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggt ggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcag gacagcaaggactccacctacagcctgagcagcaccctgacactgagcaa ggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagg gcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein7AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk SEQIDNO: prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 49 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtevvvdvshedpe vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh ytqkslslspg LightchainA Eivltqspgtlslspgctaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr SEQIDNO: fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 50 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspytksfnrgec HeavychainB qmqlqesgpglvkpsetlsltesvsgasisdsywswirrspgkglewigy SEQIDNO: vhksgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrr 51 iygivafnewftyfymdvwgngtqvtvssdkthtQvhltqsgpevrkpg tsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviver fkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddga lnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsg gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhna ktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektisk akggprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqp ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt qkslslspg LightchainB Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas SEQIDNO: srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 52 dkthtsdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgip erfsgspdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkth trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes vteqdskdstyslsstltlskadyekhkyyacevthqglsspvtksfnrgec BindingProtein7NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc SEQIDNO: ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 53 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttc cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg agccccggc LightchainA gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag SEQIDNO: ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 54 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcgg ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc cacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg SEQIDNO: agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 55 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttca acgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgacc gtgagctccgacaaaacccatacccaggtgcacctgacacagagcggacccgaag tgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccctg aaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtgga tgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggc caaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagc ggcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcacc ggctgagagactacgccctgtacgacgatgacggcgccctgaactgggccgtgga tgtggactacctgagcaacctggaattctggggccagggcacagccgtgaccgtgt catctgataagacccacaccgcttccaccaagggcccatcggtcttccccctggcac cctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagga ctacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcg tgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggt gaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca agcccagcaacaccaaggggacaagaaagttgagcccaaatcttgtgacaaaact cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaag gagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccat ctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgc cgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctat cccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactac aagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaactca ccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcat gaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt LightchainB Gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag SEQIDNO: agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 56 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctccg acatcagcgtggcccccggagagacagccaggatctcctgcggcgagaag agcctgggaagcagggctgtgcagtggtaccaacacagggccggacagg ctcccagcctgatcatctacaacaaccaggacaggcccagcggcatccctg agaggttcagcggaagccccgacagccccttcggaaccacagccaccctg accatcacaagcgtggaagccggcgacgaggccgactactactgccacatc tgggacagcagggtgcccaccaagtgggtgtttggcggcggcaccaccct gaccgtgctggataagacccatacccgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgt gcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgg acaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga cagcaaggactccacctacagcctgagcagcaccctgacactgagcaagg ccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein8AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 57 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreegynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh ytakslslspg LightchainA Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 58 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkyyacevthqglsspytksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 59 tgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvqlvesgggvv qpgtslriscaasqfrfdgygmhwvrqapgkglewvasishdgikkyha ekvwgrftisrdnskntlylqmnslrpedtalyycakdlredeceewwsd yydfgkqlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfpl apsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpa pellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalp apiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave wesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmh ealhnhytqkslslspg LightchainB Qsvltqppsvsaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkr SEQIDNO: psgipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkt 60 htaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrp sgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkt htrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqe svteqdskdstyslsstltlskadyekhkvyacevthqglsspytksfnrgec BindingProtein8NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 61 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgt accgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgt gtactactgcgccagagacagaagctacggcgacagcagctgggctctggatgctt ggggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgt gttccctctggcccctagcagaagagcacatctggcggaacagccgccctgggct gcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccct gaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcc tgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgc aacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaag agctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggagg cccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggac ccccgaagtgacctggtggtggtggatgtgtcccacgaggaccctgaagtgaagt tcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagaga ggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctg cccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctga gctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaac ggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc tcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaac gtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc cctgagcctgagccccggcaag LightchainA Tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 62 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaa gcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcag ctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaac agccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcct gagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgt acgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagct tcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 63 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa acccatacccaggtgcagttggtggagtctgggggaggcgtggtccagcctggga cgtccctgagactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcact gggtccgccaggccccaggcaaggggctggagtgggtggcatctatatcacatga tggaattaaaaagtatcacgcagaaaaagtgtggggccgcttcaccatctccagaga caattccaagaacacactgtatctacaaatgaacagcctgcgacctgaggacacgg ctctctactactgtgcgaaagatttgcgagaagacgaatgtgaagagtggtggtcgg attattacgattttgggaaacaactcccttgcgcaaagtcacgcggcggcttggttgg aattgctgataactggggccaagggacaatggtcaccgtctcttcagataagaccca caccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagca cctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaacc ggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccg gctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctcca gcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacacc aaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccacc gtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacc caaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacg tgagccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtg cataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtg gtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtg caaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagcca aagggcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagct gaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacat cgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgc ctcccgtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaa gagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgc acaaccactacacgcagaagagcctctccctgtctccgggt LightchainB Cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaa SEQIDNO: ggtcaccatctcctgctctggaaacacctccaacattggcaataattttgtgtcc 64 tggtatcaacagcgccccggcagagccccccaactcctcatttatgaaactg acaagcgaccctcagggattcctgaccgattctctgcttccaagtctggtacgt caggcaccctggccatcaccgggctgcagactggggacgaggccgattatt actgcgccacatgggctgccagcctgagttccgcgcgtgtcttcggaactgg gaccaaggtcatcgtcctggacaaaacccataccgcatccgaactgactcag gaccctgccgtctctgtggcactgaagcagactgtgactattacttgccgagg cgactcactgcggagccactacgcttcctggtatcagaagaaacccggcca ggcacctgtgctgctgttctacggaaagaacaataggccatctggcatcccc gaccgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccg gcgcccaggctgaggacgaagccgattactattgcagctcccgggataaga gcggctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcg ataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacct agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaac aacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggac tccacctacagcctgagcagcaccctgacactgagcaaggccgactacgag aagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagcccc gtgaccaagagcttcaaccggggcgagtgt BindingProtein9AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk SEQIDNO: prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 65 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh ytqkslslspg LightchainA Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr SEQIDNO: fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 66 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 67 tgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvqlvesgggvv qpgtslrlscaasqfrfdgygmhwvrqapgkglewvasishdgikkyha ekvwgrftisrdnskntlylqmnslrpedtalyycakdlredeceewwsd yydfgkqlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfpl apsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpa pellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalp apiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave wesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmh ealhnhytqkslslspg LightchainB qsvltqppsvsaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrp SEQIDNO: sgipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkth 68 taseltqdpavsvalkqtvtitcrgdsirshyaswyqkkpggapvllfygknnrps gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldktht rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes vteqdskdstysisstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein9NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc SEQIDNO: ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatc 69 agactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcg gagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgt gtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgt gtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggg gcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttc cctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcct cgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgac cagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgag cagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgt gaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagagctg cgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggccttc cgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccg aagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaatt ggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagaggaac agtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactgg ctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccccat cgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtgcac actgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggccagcc cgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct ggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctg agccccggc LightchainA gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag SEQIDNO: ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 70 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatcag caacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagitcttcgg ccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtg ttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcc tgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactc cacciacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 71 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg cgaggaatattitcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa acccatacccaggtgcagitggtggagtctgggggaggcgtggtccagcctggga cgtccctgagactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcact gggtccgccaggccccaggcaaggggctggagtgggggcatctatatcacatgat ggaattaaaaagtatcacgcagaaaaagtgtggggccgcttcaccatctccagagac aattccaagaacacactgtatctacaaatgaacagcctgcgacctgaggacacggct ctctactactgtgcgaaagatttgcgagaagacgaatgtgaagagtggtggtcggatt attacgattttgggaaacaactcccttgcgcaaagtcacgcggcggcttggttggaatt gctgataactggggccaagggacaatggtcaccgtctcttcagataagacccacacc gcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctct gggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtga cggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtc ctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagc ttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggt ggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgccc agcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaagga caccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagcca cgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataatgc caagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtc ctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctc caacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcag ccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgaccaaga atcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgtgg agtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgct ggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcaggtg gcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccacta cacgcagaagagcctctccctgtctccgggt LightchainB cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaaggtcac SEQIDNO: catctcctgctctggaaacacctccaacattggcaataattttgtgtcctggtatcaaca 72 gcgccccggcagagccccccaactcctcatttatgaaactgacaagcgaccctcag ggattcctgaccgattctctgcttccaagtctggtacgtcaggcaccctggccatcacc gggctgcagactggggacgaggccgattattactgcgccacatgggctgccagcct gagttccgcgcgtgtcttcggaactgggaccaaggtcatcgtcctg gacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggcactg aagcagactgtgactattacttgccgaggcgactcactgcggagccactacgcttcct ggtatcagaagaaacccggccaggcaccigtgctgctgttctacggaaagaacaat aggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagccagt ctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctcccg ggataagagcggctccagactgagcgtgttcggaggaggaactaaactgaccgtcc tcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctag cgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacticta cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaa cagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgag cagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgc gaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcg agtgt BindingProtein10AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlk SEQIDNO: prggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdf 73 ehwgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhnh ytqkslslspg LightchainA Eivltqspgtlslspgctaiiscrtsqygslawyqqrpgqaprlviysgstraagipdr SEQIDNO: fsgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifp 74 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB qvqlvesgggvvqpgtslriscaasqfrfdgygmhwvrqapgkglewv SEQIDNO: asishdgikkyhaekvwgrftisrdnskntlylqmnslrpedtalyycakd 75 lredeceewwsdyydfgkqlpcaksrgglvgiadnwgqgtmvtvssdk thtevrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkgle wvgritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyf cartgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfp lapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcp apellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalp apiektiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiave wesngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmh ealhnhytqkslslspg LightchainB aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg SEQIDNO: ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtq 76 svltqppsvsaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrps gipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldktht rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqes vteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein10NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatg SEQIDNO: cggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggat 77 cagactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggc ggagccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggac gtgtacagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgc cgtgtacttctgcacccggggcaagaactgcgactacaactgggacttcgagcact ggggcagaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcg tgttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggc tgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccc tgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagc ctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctg caacgtgaaccacaagcccagcaacaccaaggggacaagaaggtggaacccaa gagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggag gcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccgga cccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaag ttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagag aggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctg cccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctga gctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaac ggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc tcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaac gtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc cctgagcctgagccccggc LightchainA gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacag SEQIDNO: ccatcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagag 78 gcctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccgg aatccccgatagattcagcggctccagatggggccctgactacaacctgaccatca gcaacctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcg gccagggcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcg tgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtg cctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaac gccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagga ctccacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaag cacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgacca agagcttcaaccggggcgagtgt HeavychainB caggtgcagttggtggagtctgggggaggcgtggtccagcctgggacgtccctga SEQIDNO: gactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcactgggtccgc 79 caggccccaggcaaggggctggagtgggtggcatctatatcacatgatggaattaa aaagtatcacgcagaaaaagtgtggggccgcttcaccatctccagagacaattccaa gaacacactgtatctacaaatgaacagcctgcgacctgaggacacggctctctacta ctgtgcgaaagatttgcgagaagacgaatgtgaagagtggtggtcggattattacga ttttgggaaacaactcccttgcgcaaagtcacgcggcggcttggttggaattgctgat aactggggccaagggacaatggtcaccgtctcttcagacaaaacccataccgaggt tagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcctga gctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcagcct ccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggctgg tccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaatacc aagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattact tctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagg aatattttcaagactggggtcagggaacccttgttatcgtgtcctccgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcac ctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccg gtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccgg ctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccag cagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacacca aggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgt gcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaaccca aggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtg agccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgca taatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtc agcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaa ggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaag ggcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgac caagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgc cgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcc cgtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagc aggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaac cactacacgcagaagagcctctccctgtctccgggt LightchainB gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg SEQIDNO: tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtat 80 cagaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaat aggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgag ccagtctgaccattaccggcgcccaggctgaggacgaagccgattactattg cagctcccgggataagagcggctccagactgagcgtgttcggaggaggaa ctaaactgaccgtcctcgacaaaacccatacc cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaag gtcaccatctcctgctctggaaacacctccaacattggcaataattttgtgtcct ggtatcaacagcgccccggcagagccccccaactcctcatttatgaaactga caagcgaccctcagggattcctgaccgattctctgcttccaagtctggtacgtc aggcaccctggccatcaccgggctgcagactggggacgaggccgattatta ctgcgccacatgggctgccagcctgagttccgcgcgtgtcttcggaactggg accaaggtcatcgtcctg gataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacc tagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaac aacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggac tccacctacagcctgagcagcaccctgacactgagcaaggccgactacgag aagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagcccc gtgaccaagagcttcaaccggggcgagtgt BindingProtein11AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 81 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn hytqkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 82 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvg SEQIDNO: ritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcart 83 gkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrk pgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviv erfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyddd galnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskst sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn aktkpreegynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektis kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhy tqkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass SEQIDNO: rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 84 kthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnr psgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldk thtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspviksfnrgec BindingProtein11NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 85 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgtgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag cctgagccccggcaag LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 86 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 87 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa acccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggc acctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctg cactgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcc acgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcga ctgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggc gataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagc aacctggaattctggggccagggcacagccgtgaccgtgtcatctgataagaccca caccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcac ctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccgg tgacggtgtgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcag cgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaagg tctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag gtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaacca ctacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag SEQIDNO: agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 88 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga cctttggccagggcaccaaggtggacatcaaggacaaaacccataccgcat ccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgac tattacttgccgaggcgactcactgcggagccactacgcttcctggtatcaga agaaacccggccaggcacctgtgctgctgttctacggaaagaacaataggc catctggcatccccgaccgcttttctggcagtgcatcagggaaccgagccag tctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagc tcccgggataagagcggctccagactgagcgtgttcggaggaggaactaaa ctgaccgtcctcgataagacccatacccgtacggtggccgctcccagcgtgt tcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgt gtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggt ggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcag gacagcaaggactccacctacagcctgagcagcaccctgacactgagcaa ggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagg gcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein12AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 89 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn hytqkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 90 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB evrlvesggglvkpggsrlscsasgfdfdnawmtwvrqppgkglewvg SEQIDNO: ritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcart 91 gkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpglv kpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnyspsl ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty fymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns tyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqv ytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvl dsdgsfflyskltydksrwqggnvfscsvmhealhnhytqkslslspg LightchainB sdisvapgctariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs SEQIDNO: pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtaselt 92 qdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein12NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 93 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag cctgagccccggcaag LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 94 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 95 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggggggctatccccctgg cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa acccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcg agaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactg gagctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcac aagagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccct ggacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgac agcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgt ggccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcaccca ggtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtctt ccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgc ctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccct gaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctc agcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaa cgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatctt gtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggacc gtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccct gaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaa ctggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggag cagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactg gctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagccccca tcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacac cctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggt aaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctct actcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgc tccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctc cgggt LightchainB tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga SEQIDNO: gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 96 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca ccctgaccgtgctggacaaaacccataccgcatccgaactgactcaggacc ctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgac tcactgcggagccactacgcttcctggtatcagaagaaacccggccaggca cctgtgctgctgttctacggaaagaacaataggccatctggcatccccgacc gcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc ccaggctgaggacgaagccgattactattgcagctcccgggataagagcgg ctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataag acccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcga cgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttct acccccgcgaggccaaagtgcagtggaaggggacaacgccctgcagag cggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacc tacagcctgagcagcaccctgacactgagcaaggccgactacgagaagca caaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac caagagcttcaaccggggcgagtgt BindingProtein13AminoAcidSequences HeavychainA qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwis SEQIDNO: hegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyal 97 ydddgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggta algclvkdyfpepytyswnsgaltsgvhtfpaylqssglyslssyvtvpssslgtqt yicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtl misrtpevtcvvvdvshedpevkfnwyvdevevhnaktkpreegynstyrvvs vltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrdelt knqyslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdk srwgggnvfscsvmhealhnhytqkslslspg LightchainA dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas SEQIDNO: srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikr 98 tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesv teqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 99 rtgkyydfwwgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpgl vkpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnysps lksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewft yfymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclv kdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqty icnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkp kdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpre pqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennyktt ppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslsls pg LightchainB sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsg SEQIDNO: spdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtasel 100 tqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdr fsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaa psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein13NucleotideSequences HeavychainA caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga SEQIDNO: aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 101 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctgg cgccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgt acagcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagaccta catctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtgga acccaagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgc tgggaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatca gccggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctga agtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaag ccaagagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgct gcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggc cctgcctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcga accccaggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggt gtccctgagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatggga gagcaacggccagcccgagaacaactacaagaccaccccccctgtgctggacag cgacggctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagca gggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacaccc agaagtccctgagcctgagccccggcaag LightchainA gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 102 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctgg ccagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaa ggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactact gtatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacat caagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggc caaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctga cactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 103 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctgg cgaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaa acccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagc gagaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctact ggagctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgc acaagagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtc cctggacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctg acagcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcat cgtggccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcac ccaggtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcg gtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctggg ctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcg ccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctact ccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatc tgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagccca aatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggg gaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccgga cccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaa gttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcggg aggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccag gactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccag cccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacagg tgtacaccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggt gcctggtaaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatggg cagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctcctt cttcctctactcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtctt ctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctc cctgtctccgggt LightchainB tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga SEQIDNO: gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 104 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacc accctgaccgtgctggacaaaacccataccgcatccgaactgactcaggac cctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcga ctcactgcggagccactacgcttcctggtatcagaagaaacccggccaggc acctgtgctgctgttctacggaaagaacaataggccatctggcatccccgac cgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcg cccaggctgaggacgaagccgattactattgcagctcccgggataagagcg gctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataa gacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagc gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcag agcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcca cctacagcctgagcagcaccctgacactgagcaaggccgactacgagaag cacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtg accaagagcttcaaccggggcgagtgt BindingProtein14AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 105 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckv snkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiav ewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmheal hnhytqkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifp 106 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty slsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwm SEQIDNO: gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 107 skhrlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtevrl vesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritg pgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgky ydfwwgyppgeeyfqdwgqgtlvivssdkthtastkgpsvfplapssks tsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv tvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellg gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvev hnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiek tiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesn gqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealh nhytqkslslspg LightchainB aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg SEQIDNO: ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldktht 108 dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsg nsqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein14NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 109 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgt accgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgt gtactactgcgccagagacagaagctacggcgacagcagctgggctctggatgctt ggggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgt gttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggct gcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccct gaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcc tgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgc aacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaag agctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggagg cccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggac ccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagt tcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagaga ggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctg cccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctga gctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaac ggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc tcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaac gtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc cctgagcctgagccccggcaag LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 110 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaa gcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcag ctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaac agccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcct gagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgt acgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagct tcaaccggggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga SEQIDNO: aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 111 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac gacgatgacggcgccctgaactgggccctggatgtggactacctgagcaacctgg aattctggggccagggcacagccgtgaccgtgtcatctgacaaaacccataccgag gttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcct gagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggc tggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaat accaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatatt acttctgtgccagaacaggcaaatactacgacttctggtggggctatccccctggcg aggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgataagac ccacaccgcttccaccaagggcccatcggtcttccccctggcaccctcctccaaga gcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccga accggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttc ccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccc tccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaa caccaaggggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcc caccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaa aacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtg gacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtgga ggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccg tgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtaca agtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaa gccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgccgggat gagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagc gacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagacc acgcctcccgtgctggactccgacggctccttcttcctctactcaaaactcaccgtgg acaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggct ctgcacaaccactacacgcagaagagcctctccctgtctccgggt LightchainB gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg SEQIDNO: tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtat 112 cagaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaat aggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgag ccagtctgaccattaccggcgcccaggctgaggacgaagccgattactattg cagctcccgggataagagcggctccagactgagcgtgttcggaggaggaa ctaaactgaccgtcctcgacaaaacccataccgacttcgtgctgacccagag ccctcacagcctgagcgtgacacctggcgagagcgccagcatcagctgca agagcagccactccctgatccacggcgaccggaacaactacctggcttggt acgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggggaaaccgaggacgtgggcaccta ctactgtatgcagggcagagagagcccctggacctttggccagggcaccaa ggtggacatcaaggataagacccatacccgtacggtggccgctcccagcgt gttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtc gtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaag gtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagc aggacagcaaggactccacctacagcctgagcagcaccctgacactgagc aaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein15AminoAcidSequences HeavychainA qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwish SEQIDNO: egdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyaly 113 dddgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaal gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyi cnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmi srtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvlt vlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctippsrdeltknq vslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrw qqgnvfscsvmhealhnhytqksislspg LightchainA dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass SEQIDNO: rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrt 114 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 115 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpglv kpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnyspsl ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty fymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd tlmisrtpevtcvvvdvshedpevkfhwyvdgvevhnaktkpreeqyns tyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqv ytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvl dsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg LightchainB sdisvapgctariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs SEQIDNO: pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtaselt 116 qdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds kdstyslsstltlskadyckhkyyacevthqglsspvtksfnrgec BindingProtein15NucleotideSequences HeavychainA caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga SEQIDNO: aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 117 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggc gccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtac agcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacat ctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacc caagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgg gaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagcc ggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtg aagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgc ctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaacccc aggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccct gagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagca acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacg gctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggca acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagt ccctgagcctgagccccggcaag LightchainA gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 118 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctg aagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacac tgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 119 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcga gaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactgg agctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcaca agagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctg gacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgaca gcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtg gccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcacccag gtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtcttc cccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcct ggtcaaggactacttccccgaaccggtgacggtgtgtggaactcaggcgccctga ccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcag cagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacg tgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgt gacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtc agtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgag gtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactg gtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcag tacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctg aatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcga gaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctg cccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaa aggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggag aacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctact caaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctcc gtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccg ggt LightchainB tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga SEQIDNO: gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 120 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca ccctgaccgtgctggacaaaacccataccgcatccgaactgactcaggacc ctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgac tcactgcggagccactacgcttcctggtatcagaagaaacccggccaggca cctgtgctgctgttctacggaaagaacaataggccatctggcatccccgacc gcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc ccaggctgaggacgaagccgattactattgcagctcccgggataagagcgg ctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataag acccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcga cgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttct acccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagag cggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacc tacagcctgagcagcaccctgacactgagcaaggccgactacgagaagca caaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac caagagcttcaaccggggcgagtgt BindingProtein16AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 121 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn hytqkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnitisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 122 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys1 sstltlskadyekhkvyacevthqglsspytksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 123 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqmqlqesgpglv kpsetlsltcsvsgasisdsywswirrspgkglewigyvhksgdtnyspsl ksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygivafnewfty fymdvwgngtqvtvssdkthtastkgpsvfplapsskstsggtaalgclvk dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd tlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns tyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqv ytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttppvl dsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspg LightchainB sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs SEQIDNO: pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtaselt 124 qdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrf sgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaap svfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein16NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 125 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag cctgagccccggcaag LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 126 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 127 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccagatgcagctgcaggagagcggccctggactcgtgaagcccagcga gaccctgagcctgacatgcagcgtgagcggcgccagcatcagcgacagctactgg agctggatcaggaggagccctggcaagggcctggagtggatcggctacgtgcaca agagcggcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctg gacaccagcaagaaccaggtgagcctgtccctggtggctgccacagctgctgaca gcggcaagtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtg gccttcaacgagtggttcacctacttctacatggacgtgtggggcaacggcacccag gtgaccgtgagctccgataagacccacaccgcttccaccaagggcccatcggtcttc cccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcct ggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctga ccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcag cagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacg tgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgt gacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtc agtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgag gtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactg gtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcag tacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctg aatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcga gaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctg cccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaa aggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggag aacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctact caaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctcc gtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccg ggt LightchainB tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga SEQIDNO: gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 128 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca ccctgaccgtgctggacaaaacccataccgcatccgaactgactcaggacc ctgccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgac tcactgcggagccactacgcttcctggtatcagaagaaacccggccaggca cctgtgctgctgttctacggaaagaacaataggccatctggcatccccgacc gcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgc ccaggctgaggacgaagccgattactattgcagctcccgggataagagcgg ctccagactgagcgtgttcggaggaggaactaaactgaccgtcctcgataag acccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcga cgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttct acccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagag cggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacc tacagcctgagcagcaccctgacactgagcaaggccgactacgagaagca caaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac caagagcttcaaccggggcgagttgt BindingProtein17AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 129 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn hytqkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 130 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwm SEQIDNO: gwishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakg 131 skhrlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtqm qlqesgpglvkpsetlsltesvsgasisdsywswirrspgkglewigyvhk sgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrriygi vafnewflyfymdvwgngtqvtvssdkthtastkgpsvfplapsskstsg gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhna ktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektisk akgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqp ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt qkslslspg LightchainB sdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs SEQIDNO: pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtdfvlt 132 qsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassrasg vpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkthtr tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesv teqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein17NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 133 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag cctgagccccggcaag LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 134 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga SEQIDNO: aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 135 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg aattctggggccagggcacagccgtgaccgtgtcatctgacaaaacccatacccag atgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctgagc ctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctggatca ggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcggcg acaccaactacagcccctccctgaagtccagggtgaacctgtccctggacaccagc aagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggcaagta ctactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttcaacg agtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgaccgtga gctccgataagacccacaccgcttccaccaagggcccatcggtcttccccctggcac cctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagga ctacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcg tgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggt gaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca agcccagcaacaccaaggggacaagaaagttgagcccaaatcttgtgacaaaact cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaag gagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccat ctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgc cgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctat cccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactac aagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaactca ccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcat gaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt LightchainB tccgacatcagcgtggcccccggagagacagccaggatctcctgcggcga SEQIDNO: gaagagcctgggaagcagggctgtgcagtggtaccaacacagggccgga 136 caggctcccagcctgatcatctacaacaaccaggacaggcccagcggcatc cctgagaggttcagcggaagccccgacagccccttcggaaccacagccac cctgaccatcacaagcgtggaagccggcgacgaggccgactactactgcc acatctgggacagcagggtgcccaccaagtgggtgtttggcggcggcacca ccctgaccgtgctggacaaaacccataccgacttcgtgctgacccagagccc tcacagcctgagcgtgacacctggcgagagcgccagcatcagctgcaaga gcagccactccctgatccacggcgaccggaacaactacctggcttggtacgt gcagaagcccggcagatccccccagctgctgatctacctggccagcagca gagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggact tcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactact gtatgcagggcagagagagcccctggacctttggccagggcaccaaggtg gacatcaaggataagacccatacccgtacggtggccgctcccagcgtgttca tcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtg cctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgga caacgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggac agcaaggactccacctacagcctgagcagcaccctgacactgagcaaggc cgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcc tgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein18AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 137 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealh nhytqkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifp 138 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthgglsspvtksfnrgec HeavychainB qmqlqesgpglvkpsetlsltesvsgasisdsywswirrspgkglewigy SEQIDNO: vhksgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrr 139 iygivafnewftyfymdvwgngtqvtvssdkthtevrlvesggglvkpg gslrlscsasgfdfdnawmtwvrqppgkglewvgritgpgegwsvdya esvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfwsgyppg eeyfqdwgqgtlvivssdkthtastkgpsvfplapsskstsggtaalgclvk dyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyic nvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkd tlmisrtpevtcvvvdvshedpevkfhwyvdgvevhnaktkpreeqyn styrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepq vytlppcrdeltknqvslwclvkgfypsdiavewesngqpennykttpp vldsdgsfflyskltydksrwqqgnvfscsvmhealhnhytqkslslspg LightchainB aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg SEQIDNO: ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthts 140 disvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiperfsgs pdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtrtvaa psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein18NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 141 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag cctgagccccggcaag LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 142 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg SEQIDNO: agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 143 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttca acgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgacc gtgagctccgacaaaacccataccgaggttagactggtggagtcaggaggggggc ttgtgaagcccggtgggtctctccgcctgagctgttctgcctccggctttgatttcgata acgcctggatgacctgggtcaggcagcctccaggtaagggactggagtgggtggg aagaatcacaggtccaggcgagggctggtccgtggactacgcggaatctgttaaag ggcggtttacaatctcaagggacaataccaagaataccttgtatttggagatgaacaa cgtgagaactgaagacaccggatattacttctgtgccagaacaggcaaatactacga cttctggtccggctatccccctggcgaggaatattttcaagactggggtcagggaacc cttgttatcgtgtcctccgataagacccacaccgcttccaccaagggcccatcggtctt ccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgc ctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccct gaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctc agcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaa cgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatctt gtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggacc gtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccct gaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaa ctggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcgggaggag cagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactg gctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagccccca tcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacac cctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggt aaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctct actcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgc tccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctc cgggt LightchainB gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg SEQIDNO: tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 144 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact aaactgaccgtcctcgacaaaacccatacctccgacatcagcgtggccccc ggagagacagccaggatctcctgcggcgagaagagcctgggaagcaggg ctgtgcagtggtaccaacacagggccggacaggctcccagcctgatcatcta caacaaccaggacaggcccagcggcatccctgagaggttcagcggaagcc ccgacagccccttcggaaccacagccaccctgaccatcacaagcgtggaa gccggcgacgaggccgactactactgccacatctgggacagcagggtgcc caccaagtgggtgtttggcggcggcaccaccctgaccgtgctggataagac ccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacg agcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctac ccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccaccta cagcctgagcagcaccctgacactgagcaaggccgactacgagaagcaca aggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgacca agagcttcaaccggggcgagtgt BindingProtein19AminoAcidSequences HeavychainA evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritgp SEQIDNO: gegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfws 145 gyppgeeyfqdwgqgtlvivssastkgpsvfplapsskstsggtaalgclvkdyfp epvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtvicnvnhkpsn tkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvv vdvshedpevkfnwyvdgvevhnaktkpreegynstyrvvsvltvlhqdwlng keykckysnkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgf ypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscs vmhealhnhytqkslslspg LightchainA aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg SEQIDNO: ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvlsqpka 146 apsvtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqs nnkyaassylsltpeqwkshrsyscqvthegstvektvaptecs HeavychainB qmqlqesgpglvkpsetlsltcsvsgasisdsywswirrspgkglewigy SEQIDNO: vhksgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrr 147 iygivafnewftyfymdvwgngtqvtvssdkthtQvhltqsgpevrkpg tsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviver fkakvtidwdrstntaylqlsgltsgdtavyycakgskhrirdyalydddga lnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsg gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhna ktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektisk akgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqp ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt qkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass SEQIDNO: rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 148 kthtsdisvapgctarisegekslgsravqwyqhragqapsliiynnqdrpsgiper fsgspdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtrt vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein19NucleotideSequences HeavychainA gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 149 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgcgtcga ccaagggccccagcgtgttccctctggcccctagcagcaagagcacatctggcgga acagccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcc tggaattctggcgccctgaccagcggcgtgcacacctttccagctgtgctgcagtcc agcggcctgtacagcctgagcagcgtcgtgacagtgcccagcagctctctgggcac ccagacctacatctgcaacgtgaaccacaagcccagcaacaccaaggtggacaag aaggtggaacccaagagctgcgacaagacccacacctgtcccccttgtcctgcccc cgaactgctgggaggcccttccgtgttcctgttccccccaaagcccaaggacaccct gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccacgagg accctgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaag accaagccaagagaggaacagtacaacagcacctaccgggtggtgtccgtgctga ccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa caaggccctgcctgcccccatcgagaaaaccatcagcaaggccaagggccagcc ccgcgaaccccaggtgtgcacactgcccccaagcagggacgagctgaccaagaa ccaggtgtccctgagctgtgccgtgaaaggcttctacccctccgatatcgccgtgga atgggagagcaacggccagcccgagaacaactacaagaccaccccccctgtgctg gacagcgacggctcattcttcctggtgtccaagctgacagtggacaagtcccggtgg cagcagggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccacta cacccagaagtccctgagcctgagccccggcaag LightchainA gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg SEQIDNO: tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 150 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact aaactgaccgtcctcagtcagcccaaggctgccccctcggtcactctgttccc gccctcgagtgaggagcttcaagccaacaaggccacactggtgtgtctcata agtgacttctacccgggagccgtgacagtggcctggaaggcagatagcagc cccgtcaaggcgggagtggagaccaccacaccctccaaacaaagcaacaa caagtacgcggccagcagctacctgagcctgacgcctgagcagtggaagtc ccacagaagctacagctgccaggtcacgcatgaagggagcaccgtggaga agacagtggcccctacagaatgttca HeavychainB cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg SEQIDNO: agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 151 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttca acgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgacc gtgagctccgacaaaacccatacccaggtgcacctgacacagagcggacccgaag tgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccctg aaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtgga tgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggc caaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagc ggcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcacc ggctgagagactacgccctgtacgacgatgacggcgccctgaactgggccgtgga tgtggactacctgagcaacctggaattctggggccagggcacagccgtgaccgtgt catctgataagacccacaccgcttccaccaagggcccatcggtcttccccctggcac cctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagga ctacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcg tgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggt gaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca agcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaact cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaag gagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccat ctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatgc cgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttctat cccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactac aagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaactca ccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcat gaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag SEQIDNO: agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 152 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctccg acatcagcgtggcccccggagagacagccaggatctcctgcggcgagaag agcctgggaagcagggctgtgcagtggtaccaacacagggccggacagg ctcccagcctgatcatctacaacaaccaggacaggcccagcggcatccctg agaggttcagcggaagccccgacagccccttcggaaccacagccaccctg accatcacaagcgtggaagccggcgacgaggccgactactactgccacatc tgggacagcagggtgcccaccaagtgggtgtttggcggcggcaccaccct gaccgtgctggataagacccatacccgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgt gcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgg acaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga cagcaaggactccacctacagcctgagcagcaccctgacactgagcaagg ccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein20AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 153 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhealhn hytqkslsispg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 154 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB qmqlqesgpglvkpsetlsltcsvsgasisdsywswirrspgkglewigy SEQIDNO: vhksgdtnyspslksrvnlsldtsknqvslslvaataadsgkyycartlhgrr 155 iygivafnewftyfymdvwgngtqvtvssdkthtQvhltqsgpevrkpg tsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviver fkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddga lnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsg gtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggps vflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhna ktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektisk akgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqp ennykttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhyt qkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass SEQIDNO: rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 156 kthtsdisvapgetariscgekslgsravqwyqhragqapsliiynnqdrpsgiper fsgspdspfgttatltitsveagdeadyychiwdsrvptkwvfgggttltvldkthtrt vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspytksfnrgec BindingProtein20NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 157 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt cagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctga gcctgagccccggcaag LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgac SEQIDNO: agagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac 158 tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacaca agcagcgtggaagatggcgtgcccagcagattttccggcagcggcttccac accagcttcaacctgaccatcagcgatctgcaggccgacgacattgccacct actattgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaag cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgc gaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB cagatgcagctgcaggagagcggccctggactcgtgaagcccagcgagaccctg SEQIDNO: agcctgacatgcagcgtgagcggcgccagcatcagcgacagctactggagctgga 159 tcaggaggagccctggcaagggcctggagtggatcggctacgtgcacaagagcg gcgacaccaactacagcccctccctgaagtccagggtgaacctgtccctggacacc agcaagaaccaggtgagcctgtccctggtggctgccacagctgctgacagcggca agtactactgtgccaggaccctgcacggcaggaggatctacggcatcgtggccttc aacgagtggttcacctacttctacatggacgtgtggggcaacggcacccaggtgac cgtgagctccgacaaaacccatacccaggtgcacctgacacagagcggacccgaa gtgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccct gaaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtgg atgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaagg ccaaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgag cggcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcac cggctgagagactacgccctgtacgacgatgacggcgccctgaactgggccgtgg atgtggactacctgagcaacctggaattctggggccagggcacagccgtgaccgtg tcatctgataagacccacaccgcttccaccaagggcccatcggtcttccccctggca ccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaagg actacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggc gtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtgg tgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcaca agcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaact cacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctc ttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgc gtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtatgttgac ggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagc acgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaa ggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaacc atctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccat gccgggatgagctgaccaagaatcaagtcagcctgtggtgcctggtaaaaggcttct atcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaact acaagaccacgcctcccgtgctggactccgacggctccttcttcctctactcaaaact caccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgc atgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag SEQIDNO: agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 160 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctccg acatcagcgtggcccccggagagacagccaggatctcctgcggcgagaag agcctgggaagcagggctgtgcagtggtaccaacacagggccggacagg ctcccagcctgatcatctacaacaaccaggacaggcccagcggcatccctg agaggttcagcggaagccccgacagccccttcggaaccacagccaccctg accatcacaagcgtggaagccggcgacgaggccgactactactgccacatc tgggacagcagggtgcccaccaagtgggtgtttggcggcggcaccaccct gaccgtgctggataagacccatacccgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgt gcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtgg acaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga cagcaaggactccacctacagcctgagcagcaccctgacactgagcaagg ccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein21AminoAcidSequences HeavychainA qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwish SEQIDNO: egdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyaly 161 dddgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaal gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyi cnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmi srtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvlt vlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrdeltknq vslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrw qqgnvfscsvmhealhnhytqkslslspg LightchainA dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass SEQIDNO: rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrt 162 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 163 tgkyydfwsgyppgeeyfqdwgqgtlvivssdktht rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgw ikpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrs ygdsswaldawgqgttvvvsadkthtastkgpsvfplapsskstsggtaal gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslg tqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfp pkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpr eeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgq prepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpenny kttppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqksls lspg LightchainB yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtaseltqd 164 pavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgipdrfsg sasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtvaapsv fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskd styslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein21NucleotideSequences HeavychainA caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga SEQIDNO: aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 165 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtctggaattctggc gccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtac agcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacat ctgcaacgtgaaccacaagcccagcaacaccaaggggacaagaaggtggaacc caagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgg gaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagcc ggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtg aagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgc ctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaacccc aggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccct gagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagca acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacg gctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggca acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagt ccctgagcctgagccccggcaag LightchainA gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 166 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctg aagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacac tgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO; cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 167 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccataccagagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgc ctctgtgcgggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttct ggttccggcaggcccctggcagaggactggaatgggtgggatggatcaagcccca gtatggcgccgtgaacttcggcggaggcttccgggatagagtgaccctgacccggg acgtgtaccgcgagatcgcctacatggacatccggggcctgaagcccgatgacacc gccgtgtactactgcgccagagacagaagctacggcgacagcagctgggctctgg atgcttggggccagggcacaaccgtggtggtgtctgccgataagacccacaccgct tccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctggg ggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggt gtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctac agtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgg gcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtgga caagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagc acctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacac cctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacg aagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataatgcca agacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcct caccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctcca acaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagcc ccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgaccaagaat caagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgtggag tgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctgg actccgacggctccttcttcctctactcaaaactcaccgtggacaagagcaggtggca gcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacac gcagaagagcctctccctgtctccgggt LightchainB tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt SEQIDNO: gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 168 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga tggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc ggcagaggcagcagactgcacatcaaggacaaaacccataccgcatccgaactga ctcaggaccctgccgtctctgtggcactgaagcagactgtgactattacttgccgagg cgactcactgcggagccactacgcttcctggtatcagaagaaacccggccaggcac ctgtgctgctgttctacggaaagaacaataggccatctggcatccccgaccgcttttct ggcagtgcatcagggaaccgagccagtctgaccattaccggcgcccaggctgagg acgaagccgattactattgcagctcccgggataagagcggctccagactgagcgtgt tcggaggaggaactaaactgaccgtcctcgataagacccatacccgtacggtggcc gctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcc tctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaag gtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagga cagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggccgac tacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccc cgtgaccaagagcttcaaccggggcgagtgt BindingProtein22AminoAcidSequences HeavychainA qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwish SEQIDNO: egdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyaly 169 dddgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapsskstsggtaal gclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyi cnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmi srtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvlt vlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrdeltknq vslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrw qqgnvfscsvmhealhnhytqkslslspg LightchainA dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylass SEQIDNO: rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrt 170 vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgw SEQIDNO: ikpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrs 171 ygdsswaldawgqgttvvvsadkthtevrlvesggglvkpggslrlscsas gfdfdnawmtwvrqppgkglewvgritgpgegwsvdyaesvkgrftis rdntkntlylemnnvrtedtgyyfcartgkyydfwsgyppgeeyfqdwg qgtlvivssdkthtastkgpsvfplapsskstsggtaalgclvkdyfpepvtv swnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsnt kvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevt cvvvdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvl hqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppcrdelt knqvslwclvkgfypsdiavewesngqpennykttppvldsdgsf LightchainB aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsg SEQIDNO: ipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldktht 172 Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhik dkthtrtvaapsvfifppsdeqlksgtasvvcllanfypreakvqwkvdnalqsgn sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein22NucleotideSequences HeavychainA caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtga SEQIDNO: aggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtg 173 cgcagcgtgccaggacagggactgcagtggatgggctggatcagccacgagggc gacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggaca gaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcgataccgc cgtgtactactgcgccaagggcagcaagcaccggctgagagactacgccctgtac gacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaacctgg aattctggggccagggcacagccgtgaccgtgtcatctgcttcgaccaagggcccc agcgtgttccctctggcccctagcagcaagagcacatctggcggaacagccgccct gggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggc gccctgaccagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtac agcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacat ctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacc caagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgg gaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagcc ggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtg aagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac caggactggctgaacggcaaagagtacaagtgaaggtgtccaacaaggccctgc ctgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaacccc aggtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccct gagctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagca acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacg gctcattcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggca acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagt ccctgagcctgagccccggcaag LightchainA gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 174 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aagcgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctg aagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacac tgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccacca gggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt HeavychainB agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 175 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgacaaaacccataccgaggttaga ctggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgcctgagctg ttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcagcctccag gtaagggactggagtgggtgggaagaatcacaggtccaggcgagggctggtccgt ggactacgcggaatctgttaaagggcggtttacaatctcaagggacaataccaagaa taccttgtatttggagatgaacaacgtgagaactgaagacaccggatattacttctgtg ccagaacaggcaaatactacgacttctggtccggctatccccctggcgaggaatattt tcaagactggggtcagggaacccttgttatcgtgtcctccgataagacccacaccgct tccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctggg ggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggt gtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctac agtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgg gcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtgga caagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagc acctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacac cctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacg aagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataatgcca agacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcct caccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctcca acaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagcc ccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgaccaagaat caagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgtggag tgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctgg actccgacggctccttcttcctctactcaaaactcaccgtggacaagagcaggtggca gcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacac gcagaagagcctctccctgtctccgggt LightchainB gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg SEQIDNO: tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 176 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact aaactgaccgtcctcgacaaaacccatacctacatccacgtgacccagagcc ccagcagcctgtccgtgtccatcggcgacagagtgaccatcaactgccaga cctctcagggcgtgggcagcgacctgcactggtatcagcacaagcctggca gagcccccaagctgctgatccaccacacaagcagcgtggaagatggcgtg cccagcagattttccggcagcggcttccacaccagcttcaacctgaccatca gcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttc ttcggcagaggcagcagactgcacatcaaggataagacccatacccgtacg gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagt ccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggc caaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcag caccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcct gcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaacc ggggcgagtgt BindingProtein23AminoAcidSequences HeavychainA evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritgp SEQIDNO: gegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfws 177 gyppgeeyfqdwgqgtlvivssastkgpsvfplapsskstsggtaalgclvkdyfp epvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsn tkvdkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvv vdvshedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlng keykckvsnkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgf ypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscs vmhealhnhytqkslslspg LightchainA Aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknrps SEQIDNO: gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvlsqpk 178 aapsvtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpsk qsnnkyaassylsltpegwkshrsyscqvthegstvektvaptecs HeavychainB rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgw SEQIDNO: ikpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrs 179 ygdsswaldawgqgttvvvsadkthtQvhltqsgpevrkpgtsvkvsck apgntlktydlhwvrsvpgqglqwmgwishegdkkviverfkakvtid wdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgalnwavd vdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsggtaalgcl vkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqt yicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfppk pkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpree qynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr epqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennyktt ppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslsls pg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas SEQIDNO: srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 180 dktht yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtrtvaaps vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein23NucleotideSequences HeavychainA gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 181 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgcgtcga ccaagggccccagcgtgttccctctggcccctagcagcaagagcacatctggcgga acagccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcc tggaattctggcgccctgaccagcggcgtgcacacctttccagctgtgctgcagtcc agcggcctgtacagcctgagcagcgtcgtgacagtgcccagcagctctctgggcac ccagacctacatctgcaacgtgaaccacaagcccagcaacaccaaggtggacaag aaggtggaacccaagagctgcgacaagacccacacctgtcccccttgtcctgcccc cgaactgctgggaggcccttccgtgttcctgttccccccaaagcccaaggacaccct gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccacgagg accctgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaag accaagccaagagaggaacagtacaacagcacctaccgggtggtgtccgtgctga ccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa caaggccctgcctgcccccatcgagaaaaccatcagcaaggccaagggccagcc ccgcgaaccccaggtgtgcacactgcccccaagcagggacgagctgaccaagaa ccaggtgtccctgagctgtgccgtgaaaggcttctacccctccgatatcgccgtgga atgggagagcaacggccagcccgagaacaactacaagaccaccccccctgtgctg gacagcgacggctcattcttcctggtgtccaagctgacagtggacaagtcccggtgg cagcagggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccacta cacccagaagtccctgagcctgagccccggcaag LightchainA gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactg SEQIDNO: tgactattacttgccgaggcgactcactgcggagccactacgcttcctggtatc 182 agaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaata ggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgc agctcccgggataagagcggctccagactgagcgtgttcggaggaggaact aaactgaccgtcctcagtcagcccaaggctgccccctcggtcactctgttccc gccctcgagtgaggagcttcaagccaacaaggccacactggtgtgtctcata agtgacttctacccgggagccgtgacagtggcctggaaggcagatagcagc cccgtcaaggcgggagtggagaccaccacaccctccaaacaaagcaacaa caagtacgcggccagcagctacctgagcctgacgcctgagcagtggaagtc ccacagaagctacagctgccaggtcacgcatgaagggagcaccgtggaga agacagtggcccctacagaatgttca HeavychainB agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 183 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgacaaaacccatacccaggtgcac ctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaaggtgtcctg caaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgcagcgtg ccaggacagggactgcagtggatgggctggatcagccacgagggcgacaagaaa gtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcacca acaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacg gcgccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggc cagggcacagccgtgaccgtgtcatctgataagacccacaccgcttccaccaaggg cccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcgg ccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaact caggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcagga ctctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacc tacatctgcaacgtgaatcacaagcccagcaacaccaaggggacaagaaagttga gcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcct ggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctc ccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgag gtcaagttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccg cgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgca ccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcc cagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccac aggtgtacaccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctg tggtgcctggtaaaaggcttctatcccagcgacatcgccgtggagtgggagagcaat gggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggct ccttcttcctctactcaaaactcaccgtggacaagagcaggtggcagcaggggaac gtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagc ctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgag SEQIDNO: agcgccagcatcagctgcaagagcagccactccctgatccacggcgaccg 184 gaacaactacctggcttggtacgtgcagaagcccggcagatccccccagct gctgatctacctggccagcagcagagccagcggcgtgcccgatagattttct ggcagcggcagcgacaaggacttcaccctgaagatcagccgggtggaaac cgaggacgtgggcacctactactgtatgcagggcagagagagcccctgga cctttggccagggcaccaaggtggacatcaaggacaaaacccatacctacat ccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggta tcagcacaagcctggcagagcccccaagctgctgatccaccacacaagca gcgtggaagatggcgtgcccagcagattttccggcagcggcttccacacca gcttcaacctgaccatcagcgatctgcaggccgacgacattgccacctactat tgtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaaggata agacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagc gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcag agcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcca cctacagcctgagcagcaccctgacactgagcaaggccgactacgagaag cacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtg accaagagcttcaaccggggcgagtgt BindingProtein24AminoAcidSequences HeavychainA evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgritgpg SEQID egwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartgkyydfwsgy NO:185 ppgeeyfqdwgqgtlvivssastkgpsvfplapsskstsggtaalgclvkdyfpep vtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkv dkkvepkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvs hedpevkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeyk ckvsnkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdi avewesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvmhea lhnhytqkslslspg LightchainA aseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgi SEQID pdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvlsqpkaa NO:186 psvtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsn nkyaassylsltpeqwkshrsyscqvthegstvektvaptecs HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg SEQID wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgsk NO:187 hrlrdyalydddgalnwavdvdylsnlefwgqgtavtvss dkthtrahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglew vgwikpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycar drsygdsswaldawgqgttvvvsadkthtastkgpsvfplapsskstsggta algclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpsssl gtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfp pkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpre eqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr epqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpennyktt ppvldsdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslsp g LightchainB yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyghkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtdfvltqsph NO:188 slsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassrasgvpdrf sgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkthtrtvaaps vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskd styslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein24NucleotideSequences HeavychainA gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgc SEQID ctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggca NO:189 gcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagggc tggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaata ccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattac ttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagg aatattttcaagactggggtcagggaacccttgttatcgtgtcctccgcgtcgaccaag ggccccagcgtgttccctctggcccctagcagcaagagcacatctggcggaacagc cgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaat tctggcgccctgaccagcggcgtgcacacctttccagctgtgtgcagtccagcggc ctgtacagcctgagcagcgtcgtgacagtgcccagcagctctctgggcacccagacc tacatctgcaacgtgaaccacaagcccagcaacaccaaggtggacaagaaggtgga acccaagagctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgct gggaggcccttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagc cggacccccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagt gaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaa gagaggaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcc tgcccccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccag gtgtgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgag ctgtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacgg ccagcccgagaacaactacaagaccaccccccctgtgtggacagcgacggctcat tcttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt cagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgag cctgagccccggcaag LightchainA gcatccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgt SEQID gactattacttgccgaggcgactcactgcggagccactacgcttcctggtatca NO:190 gaagaaacccggccaggcacctgtgctgctgttctacggaaagaacaatagg ccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagccag tctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagct cccgggataagagcggctccagactgagcgtgttcggaggaggaactaaac tgaccgtcctcagtcagcccaaggctgccccctcggtcactctgttcccgccct cgagtgaggagcttcaagccaacaaggccacactggtgtgtctcataagtgac ttctacccgggagccgtgacagtggcctggaaggcagatagcagccccgtca aggcgggagtggagaccaccacaccctccaaacaaagcaacaacaagtac gcggccagcagctacctgagcctgacgcctgagcagtggaagtcccacaga agctacagctgccaggtcacgcatgaagggagcaccgtggagaagacagtg gcccctacagaatgttca HeavychainB tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg SEQID accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcac NO:191 aagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatgg cgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagc gatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcag aggcagcagactgcacatcaaggacaaaacccataccgacttcgtgctgacccaga gccctcacagcctgagcgtgacacctggcgagagcgccagcatcagctgcaagag cagccactccctgatccacggcgaccggaacaactacctggcttggtacgtgcagaa gcccggcagatccccccagctgctgatctacctggccagcagcagagccagcggc gtgcccgatagattttctggcagcggcagcgacaaggacttcaccctgaagatcagc cgggtggaaaccgaggacgtgggcacctactactgtatgcagggcagagagagcc cctggacctttggccagggcaccaaggtggacatcaaggataagacccatacccgta cggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccg gcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgca gtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccga gcaggacagcaaggactccacctacagcctgagcagcaccctgacactgagcaag gccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtc tagccccgtgaccaagagcttcaaccggggcgagtgt LightchainB tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgaca SEQID gagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactg NO:192 gtatcagcacaagcctggcagagcccccaagctgctgatccaccacacaagc agcgtggaagatggcgtgcccagcagattttccggcagcggcttccacacca gcttcaacctgaccatcagcgatctgcaggccgacgacattgccacctactatt gtcaggtgctgcagttcttcggcagaggcagcagactgcacatcaaggacaa aacccataccgacttcgtgctgacccagagccctcacagcctgagcgtgaca cctggcgagagcgccagcatcagctgcaagagcagccactccctgatccac ggcgaccggaacaactacctggcttggtacgtgcagaagcccggcagatcc ccccagctgctgatctacctggccagcagcagagccagcggcgtgcccgat agattttctggcagcggcagcgacaaggacttcaccctgaagatcagccggg tggaaaccgaggacgtgggcacctactactgtatgcagggcagagagagcc cctggacctttggccagggcaccaaggtggacatcaaggataagacccatac ccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagc tgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcg aggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgag cagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaac cggggcgagtgt BindingProtein25AminoAcidSequences HeavychainA qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlkp SEQID rggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdfeh NO:193 wgrgtpvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgal tsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfn wyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpa piektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngq pennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshytqkslsls pg LightchainA eivltqspgtlslspgctaiiscrtsqygslawyqqrpgqaprlviysgstraagipdrf SEQID sgsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifpps NO:194 deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst ltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB evrlvesggglvkpggsrlscsasgfdfdnawmtwvrqppgkglewvgr SEQID itgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartg NO:195 kyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvqlvesgggvvqpg tslrlscaasqfrfdgygmhwvrqapgkglewvasishdgikkyhaekvw grftisrdnskntlylqmnslrpedtalyycakdlredeceewwsdyydfgk qlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfplapssksts ggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp ssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsv flfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktk preeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakg qprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpenny kttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshytqkslsls pg LightchainB qsvltqppsvsaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrps SEQID gipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkthta NO:196 seltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgip drfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtva apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein25NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgc SEQID ggatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatca NO:197 gactggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcgg agccgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgtgt acagcgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgtgt acttctgcacccggggcaagaactgcgactacaactgggacttcgagcactggggca gaggcacccctgtgatcgtgtcaagcgcgtcgaccaagggccccagcgtgttccctc tggcccctagcagcaagagcacatctggcggaacagccgccctgggctgcctcgtg aaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgaccagcg gcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgagcagcgt cgtgacagtgcccagcagctctctgggcacccagacctacatctgcaacgtgaacca caagcccagcaacaccaaggtggacaagaaggtggaacccaagagctgcgacaag acccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttccgtgttcct gttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacct gcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttcaattggtacgtgga cggcgtggaagtgcacaacgccaagaccaagccaagagaggaacagtacaacagc acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa gagtacaagtgcaaggtgtccaacaaggccctgcctgcccccatcgagaaaaccatc agcaaggccaagggccagccccgcgaaccccaggtgtgcacactgcccccaagca gggacgagctgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacc cctccgatatcgccgtggaatgggagagcaacggccagcccgagaacaactacaag accaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgacagt ggacaagtcccggtggcagcagggcaacgtgttcagctgctccgtgctgcatgaggc tctgcacagccactacacgcagaagagcctctccctgtctccgggt LightchainA Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacagc SEQID catcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagaggc NO:198 ctggacaggcccccagactcgtgatctacagcggcagcacaagagccgccggaatc cccgatagattcagcggctccagatggggccctgactacaacctgaccatcagcaac ctggaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcggccagg gcaccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtgttcatctt cccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaa caacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcaga gcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctaca gcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtac gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccg gggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgc SEQID ctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag NO:199 cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggct ggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaatac caagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattact tctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagga atattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaacccatac ccaggtgcagttggtggagtctgggggaggcgtggtccagcctgggacgtccctga gactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcactgggtccgcc aggccccaggcaaggggctggagtgggggcatctatatcacatgatggaattaaaa agtatcacgcagaaaaagtgtggggccgcttcaccatctccagagacaattccaagaa cacactgtatctacaaatgaacagcctgcgacctgaggacacggctctctactactgtg cgaaagatttgcgagaagacgaatgtgaagagtggtggtcggattattacgattttggg aaacaactcccttgcgcaaagtcacgcggcggcttggttggaattgctgataactggg gccaagggacaatggtcaccgtctcttcagataagacccacaccgcttccaccaagg gcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcgg ccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactc aggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggact ctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagaccta catctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagc ccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggg gggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccgg acccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaa gttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcggga ggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccagga ctggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccc catcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtaca ccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctgg taaaaggcttctatcccagcgacatcgccgtggagtgggagagaatgggcagccg gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctcta ctcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctc cgtgctgcatgaggctctgcacagccactacacgcagaagagcctctccctgtctcg ggt LightchainB cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaagg SEQID tcaccatctcctgctctggaaacacctccaacattggcaataattttgtgtcctgg NO:200 tatcaacagcgccccggcagagccccccaactcctcatttatgaaactgacaa gcgaccctcagggattcctgaccgattctctgcttccaagtctggtacgtcagg caccctggccatcaccgggctgcagactggggacgaggccgattattactgc gccacatgggctgccagcctgagttccgcgcgtgtcttcggaactgggacca aggtcatcgtcctggacaaaacccataccgcatccgaactgactcaggaccct gccgtctctgtggcactgaagcagactgtgactattacttgccgaggcgactca ctgcggagccactacgcttcctggtatcagaagaaacccggccaggcacctg tgctgctgttctacggaaagaacaataggccatctggcatccccgaccgcttttc tggcagtgcatcagggaaccgagccagtctgaccattaccggcgcccaggct gaggacgaagccgattactattgcagctcccgggataagagcggctccagac tgagcgtgttcggaggaggaactaaactgaccgtcctcgataagacccatacc cgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcg aggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgag cagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaac cggggcgagtgt BindingProtein26AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpqy SEQID gavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswalda NO:201 wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsga ltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfn wyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpa piektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngq pennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshytqkslsls pg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifppsd NO:202 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl tlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvgr SEQID itgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartg NO:203 kyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvqlvesgggvvqpg tslrlscaasqfrfdgygmhwvrqapgkglewvasishdgikkvhaekvw grftisrdnskntlylqmnslrpedtalyycakdlredeceewwsdvydfgk qlpcaksrgglvgiadnwgqgtmvtvssdkthtastkgpsvfplapssksts ggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp ssslgtgtyicnvnhkpsntkydkkvepkscdkthtcppcpapellggpsv flfppkpkdtlmisrtpevtcvvvdyshedpevkfnwyvdgvevhnaktk preeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakg qprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngqpenny kttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshytqkslsls pg LightchainB qsvltqppsvsaapgqkvtiscsgntsnignnfvswyqqrpgrapqlliyetdkrps SEQID gipdrfsasksgtsgtlaitglqtgdeadyycatwaaslssarvfgtgtkvivldkthta NO:204 seltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrpsgip drfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtrtva apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein26NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcg SEQID ggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggc NO:205 aggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgcc gtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgc gagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactac tgcgccagagacagaagctacggcgacagcagctgggctctggatgcttggggcca gggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtgttccctctg gcccctagcagcaagagcacatctggcggaacagccgccctgggctgcctcgtgaa ggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctgaccagcggc gtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctgagcagcgtcg tgacagtgcccagcagctctctgggcacccagacctacatctgcaacgtgaaccaca agcccagcaacaccaaggtggacaagaaggtggaacccaagagctgcgacaagac ccacacctgtcccccttgtcctgcccccgaactgctgggaggcccttccgtgttcctgtt ccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacctgcg tggtggtggatgtgtcccacgaggaccctgaagtgaagttcaattggtacgtggacgg cgtggaagtgcacaacgccaagaccaagccaagagaggaacagtacaacagcacc taccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaagag tacaagtgcaaggtgtccaacaaggccctgcctgcccccatcgagaaaaccatcagc aaggccaagggccagccccgcgaaccccaggtgtgcacactgcccccaagcagg gacgagctgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccct ccgatatcgccgtggaatgggagagcaacggccagcccgagaacaactacaagac caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgacagtg gacaagtcccggtggcagcagggcaacgtgttcagctgctccgtgctgcatgaggct ctgcacagccactacacgcagaagagcctctccctgtctccgggt LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg SEQID accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcac NO:206 aagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatgg cgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagc gatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcag aggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatcttccca cctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcgg caacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctg agcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctg cgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcg agtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccgc SEQID ctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggcag NO:207 cctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagggct ggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggacaatac caagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggatattact tctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggcgagga atattttcaagactggggtcagggaacccttgttatgtgtcctccgacaaaacccatac ccaggtgcagttggtggagtctgggggaggcgtggtccagcctgggacgtccctga gactctcctgtgcagcctctcaattcaggtttgatggttatggcatgcactgggtccgcc aggccccaggcaaggggctggagtgggtggcatctatatcacatgatggaattaaaa agtatcacgcagaaaaagtgtggggccgcttcaccatctccagagacaattccaagaa cacactgtatctacaaatgaacagcctgcgacctgaggacacggctctctactactgtg cgaaagatttgcgagaagacgaatgtgaagagtggtggtcggattattacgattttggg aaacaactcccttgcgcaaagtcacgcggcggcttggttggaattgctgataactggg gccaagggacaatggtcaccgtctcttcagataagacccacaccgcttccaccaagg gcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcgg ccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactc aggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggact ctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagaccta catctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagc ccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggg gggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccgg acccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaa gttcaactggtatgttgacggcgtggaggtgcataatgccaagacaaagccgcggga ggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccagga ctggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccc catcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtaca ccctgcccccatgccgggatgagctgaccaagaatcaagtcagcctgtggtgcctgg taaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccg gagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctcta ctcaaaactcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctc cgtgctgcatgaggctctgcacagccactacacgcagaagagcctctccctgtctccg ggt LightchainB cagtctgtgctgacgcagccgccctcagtgtctgcggccccaggacagaaggtcacc SEQID atctcctgctctggaaacacctccaacattggcaataattttgtgtcctggtatcaacagc NO:208 gccccggcagagccccccaactcctcatttatgaaactgacaagcgaccctcaggga ttcctgaccgattctctgcttccaagtctggtacgtcaggcaccctggccatcaccggg ctgcagactggggacgaggccgattattactgcgccacatgggctgccagcctgagtt ccgcgcgtgtcttcggaactgggaccaaggtcatcgtcctggacaaaacccataccg catccgaactgactcaggaccctgccgtctctgtggcactgaagcagactgtgactatt acttgccgaggcgactcactgcggagccactacgcttcctggtatcagaagaaaccc ggccaggcacctgtgctgctgttctacggaaagaacaataggccatctggcatccccg accgcttttctggcagtgcatcagggaaccgagccagtctgaccattaccggcgccca ggctgaggacgaagccgattactattgcagctcccgggataagagcggctccagact gagcgtgttcggaggaggaactaaactgaccgtcctcgataagacccatacccgtac ggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccgg cacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcag tggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgag caggacagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggc cgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtcta gccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein27AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpqy SEQID gavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswalda NO:209 wgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsga ltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfn wyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpa piektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngq pennykttppvidsdgsfflvskltvdksrwqqgnvfscsvlhealhshytqkslsis pg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfqltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifppsd NO:210 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl tlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewvg SEQID ritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcartg NO:211 kyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrkpgt svkvsckapgntlktydlhwvrsvpgqglawmgwishegdkkviverfk akvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydddgaln wavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskstsggta algclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpsssl gtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellggpsvflfp pkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpre eqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr epqvytlppcrdeltknqvslwelvkgfypsdiavewesngqpennyktt ppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshytqkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr SEQID asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkt NO:212 htaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnrps gipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldkthtr tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt egdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein27NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQID gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg NO:213 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt cagctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctga gcctgagccccggc LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt SEQID gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc NO:214 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga tggcgtgcccagcagattttccggcagcggcttccacaccagcttccagctgaccat cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQID cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc NO:215 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtca gcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaag gtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagg gcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacc aagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgcc gtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctccc gtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagca ggtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcc actacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQID ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta NO:216 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt BindingProtein28AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQID ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal NO:217 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh ytqkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvee SEQID gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifp NO:218 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQID gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca NO:219 rtgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevr kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss vvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapell ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapie ktiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewes ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhs hytqkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas SEQID srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik NO:220 dkthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkn nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein28NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 221 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctcttgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt cagctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctga gcctgagccccggc LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt SEQIDNO: gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 222 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga aggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccat cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 223 agcctccaggtaagggactggagtggggggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtca gcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaag gtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagg gcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacc aagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgcc gtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctccc gtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagca ggtggcagcaggggaacgtcttctcatgctccgtgtgcatgaggctctgcacagcc actacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 224 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt BindingProtein29AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswal 225 dawgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswn sgaltsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve pkscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedp evkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvs nkalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiave wesngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhsh ytqkslsispg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: avpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 226 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 227 rtgkyydfwsgyppgccyfqdwgqgtlvivssdkthtqvhltqsgpevr kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss vvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapell ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapie ktiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewes ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhs hytqkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas SEQIDNO: srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 228 dkthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkn nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein29NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 229 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag cctgagccccggc LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt SEQIDNO: gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 230 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga tgccgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatc agcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcg gcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatc ttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctg aacaacttctacccccgcgaggccaaagtgagtggaaggtggacaacgccctgc agagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacct acagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggt gtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttca accggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 231 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa tgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagc gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca ctacacgcagaagagcctctccctgtctccgggt LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 301 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgattacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg gcgagtgt BindingProtein30AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswald 232 awgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshyt qkslslspg LightchainA yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvee SEQIDNO: gvpsrfsgsgfhtsfqltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifp 233 psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfca 234 rtgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevr kpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkv iverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyd ddgalnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapss kstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss vvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapell ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve vhnaktkpreegynstyrvvsvltvlhqdwlngkeykckvsnkalpapie ktiskakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewes ngqpennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhs hytqkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylas SEQIDNO: srasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdik 235 dkthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygkn nrpsgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvl dkthtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgn sqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein30NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 236 gcaggcccctggcagaggactggaatgggtgggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggtggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttca attggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagagg aacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggac tggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcccc catcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtgtg cacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgttc agctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctgag cctgagccccggc LightchainA tacatccacgtgacccagagccccagagcctgtccgtgtccatcggcgacagagt SEQIDNO: gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 237 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga aggcgtgcccagcagattttccggcagcggcttccacaccagcttccagctgaccat cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 238 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttggagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctg tcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagca gcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaag gtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgc ccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaag gacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgag ccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcataa tgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagc gtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggt ctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaaggg cagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacca agaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgccgt ggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgt gctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagcag gtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcca ctacacgcagaagagcctctccctgtctccgggt LightchainB Gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 239 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggg gcgagtgt BindingProtein31AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrgapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswald 240 awgqgttvvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswns galtsgvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep kscdkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpe vkfnwyvdgvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsn kalpapiektiskakgqprepqvctlppsrdeltknqvslscavkgfypsdiavew esngqpennykttppvldsdgsfflvskltvdksrwqqgnvfscsvlhealhshyt qkslslspg LightchainA Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: avpsrfsgsgfhtsfqltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 241 sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkyyacevthqglsspvtksfnrgec HeavychainB Evrlvesggglvkpggslrlscsasgfdfdnawmtwvrqppgkglewv SEQIDNO: gritgpgegwsvdyaesvkgrftisrdntkntlylemnnvrtedtgyyfcar 242 tgkyydfwsgyppgeeyfqdwgqgtlvivssdkthtqvhltqsgpevrk pgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishegdkkviv erfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalyddd galnwavdvdylsnlefwgqgtavtvssdkthtastkgpsvfplapsskst sggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt vpssslgtqtyicnvnhkpsntkvdkkvepkscdkthtcppcpapellgg psvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhn aktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektis kakgqprepqvytlppcrdeltknqvslwclvkgfypsdiavewesngq pennykttppvldsdgsfflyskltvdksrwqqgnvfscsvlhealhshyt qkslslspg LightchainB dfvltqsphslsvtpgesasiscksshslihgdrnylawyvqkpgrspqlliylass SEQIDNO: rasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikd 243 kthtaseltqdpavsvalkqtvtitcrgdslrshyaswyqkkpgqapvllfygknnr psgipdrfsgsasgnrasltitgaqaedeadyycssrdksgsrlsvfgggtkltvldk thtrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspytksfnrgec BindingProtein31NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgc SEQIDNO: gggtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccg 244 gcaggcccctggcagaggactggaatggggggatggatcaagccccagtatggc gccgtgaacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgta ccgcgagatcgcctacatggacatccggggcctgaagcccgatgacaccgccgtg tactactgcgccagagacagaagctacggcgacagcagctgggctctggatgcttg gggccagggcacaaccgtggtggtgtctgccgcctctacaaagggccccagcgtg ttccctctggcccctagcagcaagagcacatctggcggaacagccgccctgggctg cctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaattctggcgccctg accagcggcgtgcacacctttccagctgtgctgcagtccagcggcctgtacagcctg agcagcgtcgtgacagtgcccagcagctctctgggcacccagacctacatctgcaa cgtgaaccacaagcccagcaacaccaaggggacaagaaggtggaacccaagag ctgcgacaagacccacacctgtcccccttgtcctgcccccgaactgctgggaggcc cttccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccc ccgaagtgacctgcgtggtggtggatgtgtcccacgaggaccctgaagtgaagttc aattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccaagagag gaacagtacaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccagga ctggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgcc cccatcgagaaaaccatcagcaaggccaagggccagccccgcgaaccccaggtg tgcacactgcccccaagcagggacgagctgaccaagaaccaggtgtccctgagct gtgccgtgaaaggcttctacccctccgatatcgccgtggaatgggagagcaacggc cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctggtgtccaagctgacagtggacaagtcccggtggcagcagggcaacgtgtt cagctgctccgtgctgcacgaggccctgcacagccactacacccagaagtccctga gcctgagccccggc LightchainA tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagt SEQIDNO: gaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagc 245 acaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaaga tgccgtgcccagcagattttccggcagcggcttccacaccagcttccagctgaccat cagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttc ggcagaggcagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcat cttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctg cagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccac ctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt HeavychainB gaggttagactggtggagtcaggaggggggcttgtgaagcccggtgggtctctccg SEQIDNO: cctgagctgttctgcctccggctttgatttcgataacgcctggatgacctgggtcaggc 246 agcctccaggtaagggactggagtgggtgggaagaatcacaggtccaggcgagg gctggtccgtggactacgcggaatctgttaaagggcggtttacaatctcaagggaca ataccaagaataccttgtatttcgagatgaacaacgtgagaactgaagacaccggat attacttctgtgccagaacaggcaaatactacgacttctggtccggctatccccctggc gaggaatattttcaagactggggtcagggaacccttgttatcgtgtcctccgacaaaa cccatacccaggtgcacctgacacagagcggacccgaagtgcggaagcctggca cctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgc actgggtgcgcagcgtgccaggacagggactgcagtggatgggctggatcagcca cgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgaccatcgac tgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctggcg ataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacgc cctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagca acctggaattctggggccagggcacagccgtgaccgtgtcatctgataagacccac accgcttccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacc tctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggt gacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggct gtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagc agcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaa ggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtg cccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaa ggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtga gccacgaagaccctgaggtcaagttcaactggtatgttgacggcgtggaggtgcata atgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtca gcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaag gtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagg gcagccccgagaaccacaggtgtacaccctgcccccatgccgggatgagctgacc aagaatcaagtcagcctgtggtgcctggtaaaaggcttctatcccagcgacatcgcc gtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctccc gtgctggactccgacggctccttcttcctctactcaaaactcaccgtggacaagagca ggtggcagcaggggaacgtcttctcatgctccgtgctgcatgaggctctgcacagcc actacacgcagaagagcctctccctgtctccgggt LightchainB Gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcg SEQIDNO: ccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta 247 cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggc cagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaag gacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactg tatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacatc aaggacaaaacccataccgcatccgaactgactcaggaccctgccgtctctgtggc actgaagcagactgtgactattacttgccgaggcgactcactgcggagccactacgc ttcctggtatcagaagaaacccggccaggcacctgtgctgctgttctacggaaagaa caataggccatctggcatccccgaccgcttttctggcagtgcatcagggaaccgagc cagtctgaccattaccggcgcccaggctgaggacgaagccgattactattgcagctc ccgggataagagcggctccagactgagcgtgttcggaggaggaactaaactgacc gtcctcgataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaact tctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcg gcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcc tgagcagcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgc ctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt BindingProtein32AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwikpq SEQIDNO: ygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswald 302 awgqgttvvvsaastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsg altsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesky gppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfn wyvdgyevhnaktkpreeqfnstyrvvsvltvlhgdwlngkeykckvsnkglps siektiskakgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesn gqpennykttppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqk slslslgk LightchainA Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved SEQIDNO: gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifpp 303 sdeqlksgtasvycllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysls stltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewig SEQIDNO: siypgnvntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygl 304 dwnfdvwgkgttvtvsssqvqlvesgggvvqpgrsirlscaasgftftkaw mhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlyl qmnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfpla pcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls svvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflgg psvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhn aktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektisk akgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesngqp ennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytq kslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykv SEQIDNO: snrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikg 305 qpkaapdiqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliy kasnlhtgvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleiktk gpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein32NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg SEQID gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag NO:306 gcccctggcagaggactggaatggggggatggatcaagccccagtatggcgccgtg aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc acaaccgtggtggtgtctgccgcctctacaaagggcccctcggtgttccctctggcccc ttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactac tttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacac ctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgc ccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagca acaccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgccc agcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggaca ccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccagga agatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaa gaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgac cgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaa gggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcg agcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtc cctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagca acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc tcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgt gttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgt ctctgtccctgggcaag LightchainA Tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg SEQID accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcaca NO:307 agcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggc gtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcga tctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagagg cagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatcttcccaccta gcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctac ccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt HeavychainB caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag SEQID gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca NO:308 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac cgtgacagtgtctagcagccaggtgcagctggtggaatctggcggcggagtggtgca gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgccagcacaaa gggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagcc gccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactc tggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctg tactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg acaagagccggtggcaggaaggcaacgtgttagctgctccgtgatgcacgaggccc tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:309 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc caaggccgcccccgacatccagatgacccagagccccagcagcctgtctgccagcgt gggcgacagagtgaccatcacctgtcaggccagccagaacatctacgtgtggctgaa ctggtatcagcagaagcccggcaaggcccccaagctgctgatctacaaggccagcaa cctgcacaccggcgtgcccagcagattttctggcagcggctccggcaccgacttcacc ctgacaatcagctccctgcagcccgaggacattgccacctactactgccagcagggcc agacctacccctacacctttggccagggcaccaagctggaaatcaagaccaagggcc ccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgt gaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein33AminoAcidSequences HeavychainA Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrgapgrglewvgwikpqy SEQID gavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsygdsswaldaw NO:310 gqgttvvvsaastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsg vhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcp pcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiska kgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykt tppvldsdgsfflyskltvdksrwgcgnvfscsvmhealhnhytqkslslslgk LightchainA Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikrtvaapsvfifppsd NO:311 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl skadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgvi SEQID wagggtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysy NO:312 yysmdywgqgttvtvsssqvqlvesgggvvqpgrslrlscaasgftftkaw mhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlylq mnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapc srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:313 kaapdivltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifa asnvesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikt kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstysisstltlskadyekhkvyacevthqglsspytksfnrgec BindingProtein33NucleotideSequences HeavychainA agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg SEQID gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag NO:314 gcccctggcagaggactggaatggggggatggatcaagccccagtatggcgccgtg aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc acaaccgtggtggtgtctgccgcctctacaaagggcccctcggtgttccctctggcccc ttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactac tttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacac ctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgc ccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagca acaccaaggggacaagcgggtggaatctaagtacggccctccctgccctccttgccc agcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggaca ccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccagga agatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaa gaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgac cgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaa gggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcg agcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtc cctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagca acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc tcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgt gttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgt ctctgtccctgggcaag LightchainA Tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtg SEQID accatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcaca NO:315 agcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggc gtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcga tctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagagg cagcagactgcacatcaagcgtacggtggccgctcccagcgtgttcatcttcccaccta gcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctac ccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt HeavychainB caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc SEQID ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc NO:316 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg ccagagacaagggctacagctactactacagcatggactactggggccagggcacca ccgtgaccgtgtcatcctctcaggtgcagctggtggaatctggcggcggagtggtgca gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaag ggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccg ccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactct ggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgt actctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca cctgtaacgtggaccacaagcccagcaacaccaaggggacaagcgggtggaatcta agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:317 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggggaaatcaagggccagcc caaggccgcccccgacatcgtgctgacacagagccctgctagcctggccgtgtctcct ggacagagggccaccatcacctgtagagccagcgagagcgtggaatattacgtgacc agcctgatgcagtggtatcagcagaagcccggccagccccccaagctgctgattttcg ccgccagcaacgtggaaagcggcgtgccagccagattttccggcagcggctctggca ccgacttcaccctgaccatcaaccccgtggaagccaacgacgtggccaactactactg ccagcagagccggaaggtgccctacacctttggccagggcaccaagctggaaatcaa gaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacctagc gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctaccc ccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcac cctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgac ccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein34AminoAcidSequences HeavychainA Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishe SEQID gdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydd NO:318 dgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapcsrstsestaalgclv kdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdh kpsntkvdkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvv vdvsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngke ykckvsnkglpssiektiskakgqprepqvytlppcqeemtknqvslwclvkgfyp sdiavewesngqpennykttppvldsdgsfflyskltvdksrwqegnvfscsvmhe alhnhytqkslslslgk LightchainA Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr SEQID asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtva NO:319 apsyfifppsdeqlksgtasvvcllnnfypreakyqwkydnalqsgnsqesyteqds kdstyslsstltlskadyekhkvyaceythqglsspvtksfnrgec HeavychainB Qvqlvasgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsi SEQID ypgavntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldw NO:320 nfdvwgkgttvtvsssqvqlvesgggvvqpgrslrlscaasgftftkawmh wvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlylqmn slraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapcsrst sestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvp ssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvflfp pkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkpree qfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqprep qvctlppsqeemtknqvslscavkgfypsdiavewesngqpennykttpp vldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:321 kaapdiqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykas nlhtgvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleiktkgpsr tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvte qdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein34NucleotideSequences HeavychainA caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaa SEQID ggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgc NO:322 agcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaa gaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcac caacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggc gccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccagg gcacagccgtgaccgtgtcatctgcttcgaccaagggcccctcggtgttccctctggcc ccttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggact actttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcac acctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagt gcccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagccca gcaacaccaaggggacaagcgggtggaatctaagtacggccctccctgccctccttg cccagcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaagg acaccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtccca ggaagatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgc caagaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgct gaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa caagggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagcccc gcgagcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggt gtccctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggaga gcaacggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgac ggctcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggca acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc cctgtctctgtccctgggcaag LightchainA gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc SEQID agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg NO:323 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagcgtacg gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggca cagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtgg aaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagg acagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggccgact acgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccg tgaccaagagcttcaaccggggcgagtgt HeavychainB caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag SEQID gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca NO:324 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac cgtgacagtgtctagcagccaggtgcagctggtggaatctggggcggagtggtgca gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgccagcacaaa gggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagcc gccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactc tggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctg tactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:325 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc caaggccgcccccgacatccagatgacccagagccccagcagcctgtctgccagcgt gggcgacagagtgaccatcacctgtcaggccagccagaacatctacgtgtggctgaa ctggtatcagcagaagcccggcaaggcccccaagctgctgattacaaggccagcaa cctgcacaccggcgtgcccagcagattttctggcagcggctccggcaccgacttcacc ctgacaatcagctccctgcagcccgaggacattgccacctactactgccagcagggcc agacctacccctacacctttggccagggcaccaagctggaaatcaagaccaagggcc ccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgt gaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein35AminoAcidSequences HeavychainA Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmgwishe SEQID gdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskhrlrdyalydd NO:326 dgalnwavdvdylsnlefwgqgtavtvssastkgpsvfplapcsrstsestaalgclv kdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdh kpsntkvdkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvv vdvsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngke ykckvsnkglpssiektiskakgqprepqvytlppcqeemtknqvslwclvkgfyp sdiavewesngqpennykttppvldsdgsfflyskltvdksrwqegnvfscsvmhe alhnhytqkslslslgk LightchainA Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr SEQID asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikrtva NO:327 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds kdstyslsstltlskadyekhkyyacevthqglsspytksfnrgec HeavychainB Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgvi SEQID wagggtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysy NO:328 yysmdywgqgttvtvsssqvqlvesgggvvqpgrslrlscaasgftftkaw mhwvrqapgkglewvaqikdksnsyatyyadsvkgrftisrddskntlylq mnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapc srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt ppvldsdgsfflvskltvdksrwqegnvfscsymhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:329 kaapdivltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifa asnvesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikt kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein35NucleotideSequences HeavychainA caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaa SEQID ggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgc NO:330 agcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaa gaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcac caacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggc gccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccagg gcacagccgtgaccgtgtcatctgcttcgaccaagggcccctcggtgttccctctggcc ccttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggact actttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcac acctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagt gcccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagccca gcaacaccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttg cccagcccctgaatttctgggggaccctccgtgttcctgttccccccaaagcccaagg acaccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtccca ggaagatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgc caagaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgct gaccgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaa caagggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagcccc gcgagcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggt gtccctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggaga gcaacggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgac ggctcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggca acgtgttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtc cctgtctctgtccctgggcaag LightchainA gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc SEQID agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg NO:331 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagcgtacg gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggca cagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtgg aaggtggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcagg acagcaaggactccacctacagcctgagcagcaccctgacactgagcaaggccgact acgagaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccg tgaccaagagcttcaaccggggcgagtgt HeavychainB caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc SEQID ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc NO:332 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg ccagagacaagggctacagctactactacagcatggactactggggccagggcacca ccgtgaccgtgtcatcctctcaggtgcagctggtggaatctggcggcggagtggtgca gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagat caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaag ggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccg ccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactct ggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgt actctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg acaagagccggtggcaggaaggcaacgtgttagctgctccgtgatgcacgaggccc tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:333 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc caaggccgcccccgacatcgtgctgacacagagccctgctagcctggccgtgtctcct ggacagagggccaccatcacctgtagagccagcgagagcgtggaatattacgtgacc agcctgatgcagtggtatcagcagaagcccggccagccccccaagctgctgattttcg ccgccagcaacgtggaaagcggcgtgccagccagattttccggcagcggctctggca ccgacttcaccctgaccatcaaccccgtggaagccaacgacgtggccaactactactg ccagcagagccggaaggtgccctacacctttggccagggcaccaagctggaaatcaa gaccaagggccccagccgtacggtggcgctcccagcgtgttcatcttcccacctagc gacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctaccc ccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagc caggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcac cctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgac ccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein36AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlkpr SEQ ggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdfehw NO:334 grgtpvivssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsg vhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcp pcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiska kgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykt tppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Eivltqspgtlslspgctaiiscrtsqygslawyqqrpgqaprlviysgstraagipdrfs SEQID gsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifppsd NO:335 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl skadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsi SEQID ypgnvntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygld NO:336 wnfdvwgkgttvtvsssqvqlvesgggvvqpgrslriscaasgftftkawm hwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlylqm nslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapcsr stsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt vpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvfl fppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkpr eeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslg k LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:337 kaapdiqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykas nlhtgvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleiktkgpsr tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvte qdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein36NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgcg SEQID gatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatcaga NO:338 ctggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcggagc cgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgtgtacag cgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgtgtacttct gcacccggggcaagaactgcgactacaactgggacttcgagcactggggcagaggc acccctgtgatcgtgtcaagcgcgtcgaccaagggcccctcggtgttccctctggcccc ttgcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactac tttcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacac ctttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgc ccagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagca acaccaaggggacaagcgggtggaatctaagtacggccctccctgccctccttgccc agcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggaca ccctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccagga agatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaa gaccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgtgac cgtgctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaa gggcctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcg agcctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtc cctgtggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagca acggccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggc tcattcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgt gttcagctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgt ctctgtccctgggcaag LightchainA Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacagcc SEQID atcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagaggcct NO:339 ggacaggcccccagactcgtgattacagcggcagcacaagagccgccggaatccc cgatagattcagcggctccagatggggccctgactacaacctgaccatcagcaacctg gaaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcggccagggca ccaaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtgttcatcttccca cctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaactt ctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggca acagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagc agcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcga agtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtg t HeavychainB caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag SEQID gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca NO:340 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac cgtgacagtgtctagcagccaggtgcagctggtggaatctggcggcggagtggtgca gcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggc ctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggggcccagat caaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggt tcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgc gggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgccagcacaaa gggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagcc gccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactc tggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctg tactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctaca cctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatcta agtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgt tcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgac ctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtgg acggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagc acctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaa gagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagcca ggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccc agcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagac caccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgg acaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccc tgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:341 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc caaggccgcccccgacatccagatgacccagagccccagcagcctgtctgccagcgt gggcgacagagtgaccatcacctgtcaggccagccagaacatctacgtgtggctgaa ctggtatcagcagaagcccggcaaggcccccaagctgctgatctacaaggccagcaa cctgcacaccggcgtgcccagcagattttctggcagcggctccggcaccgacttcacc ctgacaatcagctccctgcagcccgaggacattgccacctactactgccagcagggcc agacctacccctacacctttggccagggcaccaagctggaaatcaagaccaagggcc ccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagct gaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcc aaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgt gaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgacactga gcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccagggc ctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein37AminoAcidSequences HeavychainA Qvqlvqsggqmkkpgesmriscrasgyefidctlnwirlapgkrpewmgwlkpr SEQID ggavnyarplqgrvtmtrdvysdtaflelrsltvddtavyfctrgkncdynwdfehw NO:342 grgtpvivssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsg vhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcp pcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiska kgqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykt tppvldsdgsfflyskltvdksrwgcgnvfscsvmhealhnhytqkslslslgk LightchainA Eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdrfs SEQID gsrwgpdynltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifppsd NO:343 eqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl skadyekhkyyacevthqglsspvtksfnrgec HeavychainB Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgvi SEQID wagggtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysy NO:344 yysmdywgqgttvtvsssqvqlvesgggvvqpgrslrlscaasgftftkaw mhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntlylq mnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfplapc srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:345 kaapdivltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifa asnvesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikt kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspytksfnrgec BindingProtein37NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcggccagatgaagaaacccggcgagagcatgcg SEQID gatcagctgcagagccagcggctacgagttcatcgactgcaccctgaactggatcaga NO:346 ctggcccctggcaagcggcctgagtggatgggatggctgaagcctagaggcggagc cgtgaactacgccagacctctgcagggcagagtgaccatgacccgggacgtgtacag cgataccgccttcctggaactgcggagcctgaccgtggatgataccgccgtgtacttctg cacccggggcaagaactgcgactacaactgggacttcgagcactggggcagaggca cccctgtgatcgtgtcaagcgcgtcgaccaagggcccctcggtgttccctctggcccctt gcagcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactt tcccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacc tttccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcc cagcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaa caccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgccca gcccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacac cctgatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaa gatcccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaaga ccaagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgt gctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggg cctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagc ctcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctg tggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacg gccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcat tcttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct gtccctgggcaag LightchainA Gagatcgtgctgacacagagccctggcaccctgagcctgtctccaggcgagacagcc SEQID atcatcagctgccggacaagccagtacggcagcctggcctggtatcagcagaggcctg NO:347 gacaggcccccagactcgtgatctacagcggcagcacaagagccgccggaatcccc gatagattcagcggctccagatggggccctgactacaacctgaccatcagcaacctgg aaagcggcgacttcggcgtgtactactgccagcagtacgagttcttcggccagggcac caaggtgcaggtggacatcaagcgtacggtggccgctcccagcgtgttcatcttcccac ctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttc tacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaa cagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagca gcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaag tgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt HeavychainB caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc SEQID tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca NO:348 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc agagacaagggctacagctactactacagcatggactactggggccagggcaccacc gtgaccgtgtcatcctctcaggtgcagctggtggaatctggcggcggagtggtgcagc ctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaaggcctg gatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccagatcaa ggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccggttcac catcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctgcgggc cgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagccccttcgatta ctggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaagggccc atcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccgccctgg gctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactctggcgctc tgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgtactctctg agcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctacacctgtaac gtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatctaagtacgg ccctccctgccctccttgcccagcccctgaatttctgggggaccctccgtgttcctgttc cccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacctgcgtg gtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtggacggcgt ggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagcacctacc gggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaagagtacaa gtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatcagcaaggc caagggccagccccgcgagcctcaagtgtgtaccctgccccctagccaggaagagat gaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctaccccagcgacattg ccgtggaatgggagagcaacggccagcccgagaacaactacaagaccaccccccct gtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtggacaagagccg gtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccctgcacaaccac tacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca SEQID gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga NO:349 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagccca aggccgcccccgacatcgtgctgacacagagccctgctagcctggccgtgtctcctgg acagagggccaccatcacctgtagagccagcgagagcgtggaatattacgtgaccag cctgatgcagtggtatcagcagaagcccggccagccccccaagctgctgattttcgccg ccagcaacgtggaaagcggcgtgccagccagattttccggcagcggctctggcaccg acttcaccctgaccatcaaccccgtggaagccaacgacgtggccaactactactgcca gcagagccggaaggtgccctacacctttggccagggcaccaagctggaaatcaagac caagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacctagcgac gagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein38AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn SEQID vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg NO:350 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp vldsdgsfflyskltvdksrwqegnvfscsymhealhnhytqkslslslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:351 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi SEQID kpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsyg NO:352 dsswaldawgqgttvvvsasqvqlvesgggvvqpgrslrlscaasgftftka wmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntly lqmnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfpla pcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss vvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggps vflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnakt kpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvctlppsqeemtknqvslscavkgfypsdiavewesngqpenny kttppvldsdgsfflvskitvdksrwqegnvfscsvmhealhnhytqkslsls lgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:353 kaapyihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssv edgvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhiktkgpsrtvaaps vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein38NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg SEOID tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag NO:354 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgraaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA Gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagt SEQID gaccatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcaga NO:355 agcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggc gtgcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctc cctgcagcccgaggacattgccacctactactgccagcagggccagacctacccctac acctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgt tcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctg ctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgc agagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccaccta cagcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccg gggcgagtgt HeavychainB agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg SEQID gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag NO:356 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc acaaccgtggtggtgtctgcctctcaggtgcagctggtggaatctggcggcggagtggt gcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaag gcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggcccag atcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggccg gttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagcctg cgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcccctt cgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgaccaag ggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacagccg ccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaactctg gcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcctgta ctctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagacctacacc tgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatctaag tacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgtgttc ctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtgacct gcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgtggac ggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaacagcac ctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaaagag tacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatcagca aggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccaggaag agatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctaccccagcga cattgccgtggaatgggagagcaacggccagcccgagaacaactacaagaccaccc cccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtggacaag agccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccctgcac aaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB Gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:357 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagccc aaggccgccccctacatccacgtgacccagagccccagcagcctgtccgtgtccatcg gcgacagagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcact ggtatcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcagcg tggaagatggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctg accatcagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttc ttcggcagaggcagcagactgcacatcaagaccaagggccccagccgtacggtggc cgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcct ctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtg gacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagca aggactccacctacagcctgagcagcaccctgacactgagcaaggccgactacgaga agcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgacca agagcttcaaccggggcgagtgt BindingProtein39AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn SEQID vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg NO:358 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp vidsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:359 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthgglsspvtksfnrgec HeavychainB Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi SEQID kpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsyg NO:360 dsswaldawgqgttvvvsadkthtqvqlvesgggvvqpgrslrlscaasgftf tkawmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskn tlylqmnslraedtavyycrgvyyalspfdywgqgtlvtvssdkthtastkgp svfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss glyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpap eflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiekti skakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesngq pennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytq kslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth NO:361 tyihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtrtvaapsvfif ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein39NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg SEQID tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag NO:362 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg SEQID accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa NO:363 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt HeavychainB agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg SEQID gtgtcctgtcagacaagggctacaccttcaccgcccacatcctgttctggttccggcag NO:364 gcccctggcagaggactggaatgggtgggatggatcaagccccagtatggcgccgtg aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc acaaccgtggtggtgtctgccgacaaaacccatacccaggtgcagctggtggaatctg gcggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtacta tgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgataa gacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagcaga agcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagc ccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagcc gtgctccagagcagcggcctgtactctctgagcagcgtgtgacagtgcccagcagca gcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaagg tggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaa tttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatc agccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgag gtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccca gagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcacca ggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccag ctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtg taccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg gcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca SEQID gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga NO:365 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaaccc atacctacatccacgtgacccagagccccagcagctgtccgtgtccatcggcgacag agtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcag cacaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagat ggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcag cgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcag aggcagcagactgcacatcaaggataagacccatacccgtacggtggccgctcccag cgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtg cctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgc cctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcc acctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttca accggggcgagtgt BindingProtein40AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypg SEQID nvntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgk NO:366 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:367 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty slsstltlskadyekhkyyacevthqglsspvtksfnrgec HeavychainB Qvalvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewva SEQID qikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvy NO:368 yalspfdywgqgtlvtvsssrahlvqsgtamkkpgasvrvscqtsgytftahi lfwfrqapgrglewvgwikpqygavnfgggfrdrvtltrdvyreiaymdirg lkpddtavyycardrsygdsswaldawgqgttvvvsartastkgpsvfplap csrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv vtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggps vflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnakt kpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvctlppsqeemtknqvslscavkgfypsdiavewesngqpenny kttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslsls lgk LightchainB Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikgqpkaapdivmtqt NO:369 plslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpd rfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveiktkgpsrtvaaps vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein40NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg SEQID tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag NO:370 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactcttgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg SEQID accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa NO:371 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga SEQID ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc NO:372 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac cctcgtgaccgtgtctagtagcagagcccacctggtgcagtctggcaccgccatgaag aaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggctacaccttcaccgccc acatcctgttctggttccggcaggcccctggcagaggactggaatgggtgggatggat caagccccagtatggcgccgtgaacttcggggaggcttccgggatagagtgaccctg acccgggacgtgtaccgcgagatcgcctacatggacatccggggcctgaagcccgat gacaccgccgtgtactactgcgccagagacagaagctacggcgacagcagctgggct ctggatgcttggggccagggcacaaccgtggtggtgtctgcccggaccgccagcaca aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaaggggtggaatc taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt gttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag gaagagatgaccaagaaccaggtgtccctgagtgtgccgtgaaaggcttctacccca gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct gcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacag SEQID agtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggt NO:373 atcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcag cgtggaagatggcgtgcccagcagattttccggcagcggcttccacaccagctt caacctgaccatcagcgatctgcaggccgacgacattgccacctactattgtca ggtgctgcagttcttcggcagaggcagcagactgcacatcaagggccagccca aggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtgac acctggacagcctgccagcatcagctgcaagagcagccagagcctggtgcac aacaacgccaacacctacctgagctggtatctgcagaagcccggccagagcc cccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgacagat tctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtggaa gccgaggacgtgggcgtgtactattgtggccagggcacccagtaccccttcac cttggcagcggcaccaaggtggaaatcaagaccaagggccccagccgtacg gtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtcc ggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaa gtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagc gtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctga cactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgac ccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein41AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn SEQID vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg NO:374 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:375 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq SEQID ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy NO:376 alspfdywgqgtlvtvssdkthtrahlvqsgtamkkpgasvrvscqtsgytft ahilfwfrqapgrglewvgwikpqygavnfgggfrdrvtltrdvyreiaym dirglkpddtavyycardrsygdsswaldawgqgttvvvsadkthtastkgp svfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss glyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpap eflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiekti skakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesngq pennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytq kslslslgk LightchainB Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtdivmtqtplsl NO:377 svtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpdrfs gsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkthtrtvaapsvfif ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl sstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein41NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg SEQID tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag NO:378 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg SEQID accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa NO:379 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga SEQID ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc NO:380 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac cctcgtgaccgtgtctagtgacaaaacccataccagagcccacctggtgcagtctggca ccgccatgaagaaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggctacac cttcaccgcccacatcctgttctggttccggcaggcccctggcagaggactggaatggg tgggatggatcaagccccagtatggcgccgtgaacttcggcggaggcttccgggatag agtgaccctgacccgggacgtgtaccgcgagatcgcctacatggacatccggggcct gaagcccgatgacaccgccgtgtactactgcgccagagacagaagctacggcgacag cagctgggctctggatgcttggggccagggcacaaccgtggtggtgtctgccgataag acccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcagcagaa gcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagcc cgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagccg tgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagcag cctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaaggt ggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaat ttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatca gccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgagg tgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcccag agaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccag gactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccagc tccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtgt accctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg gcaag LightchainB tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtga SEQID ccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcacaa NO:381 gcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggcgt gcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcgatc tgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagaggca gcagactgcacatcaaggacaaaacccataccgacatcgtgatgacccagacccccct gagcctgagcgtgacacctggacagcctgccagcatcagctgcaagagcagccaga gcctggtgcacaacaacgccaacacctacctgagctggtatctgcagaagcccggcca gagcccccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgacaga ttctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtggaagccg aggacgtgggcgtgtactattgtggccagggcacccagtaccccttcacctttggcagc ggcaccaaggtggaaatcaaggataagacccatacccgtacggtggccgctcccagc gtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgc ctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaacgcc ctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactcca cctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcacaag gtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttca accggggcgagtgt BindingProtein42AminoAcidSequences HeavychainA Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg SEQID tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq NO:382 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa NO:383 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi SEQID kpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtavyycardrsyg NO:384 dsswaldawgqgttvvvsasqvqlvesgggvvqpgrslrlscaasgftftka wmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddskntly lqmnslraedtavyycrgvyyalspfdywgqgtlvtvssrtastkgpsvfpla pcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss vvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggps vflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnakt kpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvctlppsqeemtknqvslscavkgfypsdiavewesnggpenny kttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslsls lgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylgkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:385 kaapyihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssv edgvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhiktkgpsrtvaaps vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein42NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc SEQID ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc NO:386 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg ccagagacaagggctacagctactactacagcatggactactggggccagggcacca ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc ccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct gtccctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:387 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa gagcttcaaccggggcgagtgt HeavychainB agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg SEQID gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag NO:388 gcccctggcagaggactggaatggggggatggatcaagccccagtatggcgccgtg aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc acaaccgtggtggtgtctgcctctcaggtgcagctggtggaatctggggcggagtgg tgcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcaccaa ggcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggccc agatcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggc cggttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagc ctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcc ccttcgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgacc aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaat ctaagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctcc gtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaag tgacctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtac gtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaa cagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacgg caaagagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaac catcagcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctag ccaggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctac cccagcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaa gaccaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccg tggacaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgagg ccctgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:389 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc caaggccgccccctacatccacgtgacccagagccccagcagcctgtccgtgtccatc ggcgacagagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcac tggtatcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcagc gtggaagatggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacct gaccatcagcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagtt cttcggcagaggcagcagactgcacatcaagaccaagggccccagccgtacggtgg ccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagc ctctgtcgtgtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaagg tggacaacgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacag caaggactccacctacagcctgagcagcaccctgacactgagcaaggccgactacga gaagcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgac caagagcttcaaccggggcgagtgt BindingProtein43AminoAcidSequences HeavychainA Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwagg SEQID gtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywg NO:390 qgttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgv htfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcpp cpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskak gqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennyktt ppvldsdgsfflyskltvdksrwqegnyfscsymhealhnhytqkslslslgk LightchainA Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtva NO:391 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds kdstyslsstltlskadyekhkvyacevthqglsspytksfnrgec HeavychainB Rahlvqsgtamkkpgasvrvscqtsgytftahilfwfrqapgrglewvgwi SEQID kpqygavnfgggfrdrvtltrdvyreiaymdirglkpddtayyycardrsyg NO:392 dsswaldawgqgttvvvsadkthtqvqlvesgggvvqpgrslriscaasgft ftkawmhwvrqapgkqlewvaqikdksnsyatyyadsvkgrftisrddsk ntlylqmnslraedtavyycrgvyyalspfdywgqgtlvtvssdkthtastkg psvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs sglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpa peflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgv evhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiek tiskakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesng qpennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhy tqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylakpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkt NO:393 htyihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssved gvpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikdkthtrtvaapsvfi fppsdeqlksgtasvvclinnfypreakvqwkvdnalqsgnsqesvteqdskdsty slsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein43NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc SEQID ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc NO:394 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg ccagagacaagggctacagctactactacagcatggactactggggccagggcacca ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc ccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct gtccctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:395 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa gagcttcaaccggggcgagtgt HeavychainB agagcccacctggtgcagtctggcaccgccatgaagaaaccaggcgcctctgtgcgg SEQID gtgtcctgtcagacaagcggctacaccttcaccgcccacatcctgttctggttccggcag NO:396 gcccctggcagaggactggaatggggggatggatcaagccccagtatggcgccgtg aacttcggcggaggcttccgggatagagtgaccctgacccgggacgtgtaccgcgag atcgcctacatggacatccggggcctgaagcccgatgacaccgccgtgtactactgcg ccagagacagaagctacggcgacagcagctgggctctggatgcttggggccagggc acaaccgtggtggtgtctgccgacaaaacccatacccaggtgcagctggtggaatctg gggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtact atgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgat aagacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagca gaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccga gcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccag ccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcag cagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaa ggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccct gaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgat gatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgtg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagc tgtgccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcc agcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattctt cctggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcag ctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgt ccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:397 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaacc catacctacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgaca gagtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatca gcacaagcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaag atggcgtgcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatc agcgatctgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggc agaggcagcagactgcacatcaaggataagacccatacccgtacggtggccgctccc agcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgt gtgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaa cgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggac tccacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcac aaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagc ttcaaccggggcgagtgt BindingProtein44AminoAcidSequences HeavychainA Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg SEQID tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq NO:398 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltydksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa NO:399 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk dstyslsstltlskadyekhkyyacevthqglsspvtksfnrgec HeavychainB Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq SEQID ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy NO:400 alspfdywgqgtlvtvsssrahlvqsgtamkkpgasvrvscqtsgytftahilf wfrqapgrglewvgwikpqygavnfgggfrdrvtltrdvyreiaymdirgl kpddtavyycardrsygdsswaldawgqgttvvvsartastkgpsvfplapc srstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv tvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpapeflggpsvf lfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevhnaktkp reeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgqpr epqvctlppsqeemtknqvslscavkgfypsdiavewesngqpennyktt ppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainB Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfnltisdlqaddiatyycqvlqffgrgsrlhikgqpkaapdivmtqt NO:401 plslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpd rfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveiktkgpsrtvaaps vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskds tyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein44NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc SEQID ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc NO:402 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg ccagagacaagggctacagctactactacagcatggactactggggccagggcacca ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc ccctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct gtccctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:403 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa gagcttcaaccggggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgag SEQID actgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgc NO:404 caggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacag ctacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacga cagcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccg tgtactactgtcggggcgtgtactatgccctgagccccttcgattactggggccaggga accctcgtgaccgtgtctagtagcagagcccacctggtgcagtctggcaccgccatga agaaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggctacaccttcaccgc ccacatcctgttctggttccggcaggcccctggcagaggactggaatgggtgggatgg atcaagccccagtatggcgccgtgaacttcggcggaggcttccgggatagagtgaccc tgacccgggacgtgtaccgcgagatcgcctacatggacatccggggcctgaagcccg atgacaccgccgtgtactactgcgccagagacagaagctacggcgacagcagctggg ctctggatgcttggggccagggcacaaccgtggtggtgtctgcccggaccgccagca caaagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctac agccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctgg aactctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcg gcctgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaaga cctacacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtg gaatctaagtacggccctccctgccctccttgcccagcccctgaatttctgggcggacc ctccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccccc gaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattg gtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagt tcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaa cggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaa aaccatcagcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccc tagccaggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttc taccccagcgacattgccgtggaatgggagagcaacggccagcccgagaacaacta caagaccaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctga ccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacg aggccctgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacag SEQID agtgaccatcaactgccagacctctcagggcgtgggcagcgacctgcactggt NO:405 atcagcacaagcctggcagagcccccaagctgctgatccaccacacaagcag cgtggaagatggcgtgcccagcagattttccggcagcggcttccacaccagctt caacctgaccatcagcgatctgcaggccgacgacattgccacctactattgtca ggtgctgcagttcttcggcagaggcagcagactgcacatcaagggccagccc aaggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtga cacctggacagcctgccagcatcagctgcaagagcagccagagcctggtgca caacaacgccaacacctacctgagctggtatctgcagaagcccggccagagc ccccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgacag attctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtgg aagccgaggacgtgggcgtgtactattgtggccagggcacccagtaccccttc acctttggcagcggcaccaaggtggaaatcaagaccaagggccccagccgta cggtggccgctcccagcgtgttcatcttcccacctagcgacgagcagctgaagt ccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgaggcca aagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagt gt BindingProtein45AminoAcidSequences HeavychainA Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwagg SEQID gtnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywg NO:406 qgttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgv htfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcpp cpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskak gqprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennyktt ppvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtva NO:407 apsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqds kdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq SEQID ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy NO:408 alspfdywgqgtlvtvssdkthtrahlvqsgtamkkpgasvrvscqtsgytft ahilfwfrqapgrglewvgwikpqygavnfgggfrdrvtltrdvyreiaym dirglkpddtavyycardrsygdsswaldawgqgttvvvsadkthtastkgp svfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss glyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcpap eflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgve vhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiekt iskakgqprepqvctlppsqeemtknqvslscavkgfypsdiavewesng qpennykttppvldsdgsfflvskltvdksrwqegnvfscsvmhealhnhy tqkslslslgk LightchainB Yihvtqspsslsvsigdrvtincqtsqgvgsdlhwyqhkpgrapkllihhtssvedg SEQID vpsrfsgsgfhtsfhltisdlqaddiatyycqvlqffgrgsrlhikdkthtdivmtqtpls NO:409 lsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvsnrfsgvpdrfs gsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkthtrtvaapsvfi fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty slsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein45NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagc SEQID ctgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcc NO:410 agccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcacc aactacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaac caggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcg ccagagacaagggctacagctactactacagcatggactactggggccagggcacca ccgtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgc agcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttc ccgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacaccttt ccagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgccca gcagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaaca ccaaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagc ccctgaatttctgggggaccctccgtgttcctgttccccccaaagcccaaggacaccct gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct gtccctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:411 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccg ctcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctct gtcgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtgg acaatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaa ggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaa gcacaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaa gagcttcaaccggggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgag SEQID actgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgc NO:412 caggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacag ctacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacga cagcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccg tgtactactgtcggggcgtgtactatgccctgagccccttcgattactggggccaggga accctcgtgaccgtgtctagtgacaaaacccataccagagcccacctggtgcagtctgg caccgccatgaagaaaccaggcgcctctgtgcgggtgtcctgtcagacaagcggcta caccttcaccgcccacatcctgttctggttccggcaggcccctggcagaggactggaat gggtgggatggatcaagccccagtatggcgccgtgaacttcggcggaggcttccggg atagagtgaccctgacccgggacgtgtaccgcgagatcgcctacatggacatccggg gcctgaagcccgatgacaccgccgtgtactactgcgccagagacagaagctacggcg acagcagctgggctctggatgcttggggccagggcacaaccgtggtggtgtctgccg ataagacccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctg atgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatc ccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacca agcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgct gcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcct gcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctc aagtgtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgag ctgtgccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggc cagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattct tcctggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttca gctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctg tccctgggcaag LightchainB tacatccacgtgacccagagccccagcagcctgtccgtgtccatcggcgacagagtga SEQID ccatcaactgccagacctctcagggcgtgggcagcgacctgcactggtatcagcacaa NO:413 gcctggcagagcccccaagctgctgatccaccacacaagcagcgtggaagatggcgt gcccagcagattttccggcagcggcttccacaccagcttcaacctgaccatcagcgatc tgcaggccgacgacattgccacctactattgtcaggtgctgcagttcttcggcagaggc agcagactgcacatcaaggacaaaacccataccgacatcgtgatgacccagaccccc ctgagcctgagcgtgacacctggacagcctgccagcatcagctgcaagagcagccag agcctggtgcacaacaacgccaacacctacctgagctggtatctgcagaagcccggc cagagcccccagtccctgatctacaaggtgtccaacagattcagcggcgtgcccgaca gattctccggcagcggctctggcaccgacttcaccctgaagatcagccgggtggaagc cgaggacgtgggcgtgtactattgtggccagggcacccagtaccccttcacctttggca gcggcaccaaggtggaaatcaaggataagacccatacccgtacggtggccgctccca gcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtg tgcctgctgaacaacttctacccccgcgaggccaaagtgcagtggaaggtggacaac gccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggact ccacctacagcctgagcagcaccctgacactgagcaaggccgactacgagaagcaca aggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagctt caaccggggcgagtgt BindingProtein46AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypg SEQID nvntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgk NO:414 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:415 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdsty slsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg SEQID wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh NO:416 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvsssqvqlvesgggv vqpgrsrlscaasgflftkawmhwvrqapgkqlewvaqikdksnsyatyy adsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdywgqg tlvtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs vmhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:417 kaapdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliyl assrasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikt kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein46NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaag SEQID gtgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgcca NO:418 ggcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacac caactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcag caccgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactg cacccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccac cgtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgca gcagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcc cgagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttc cagccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccag cagcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacac caaggtggacaagcgggtggaatctaagtacggcccccctgccctccttgcccagcc cctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccct gatgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagat cccgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagacc aagcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtg ctgcaccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggc ctgcccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcc tcaagtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgt ggtgtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacgg ccagcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcatt cttcctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttc agctgctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctct gtccctgggcaag LightchainA gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg SEQID accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa NO:419 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgta cgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccg gggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaa SEQID ggtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgc NO:420 agcgtgccaggacagggactgcagtggatgggctggatcagccacgaggggacaa gaaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcac caacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactact gcgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggc gccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccagg gcacagccgtgaccgtgtcatcttctcaggtgcagctggtggaatctggcggcggagt ggtgcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcacc aaggcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggc ccagatcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagg gccggttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaaca gcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgag ccccttcgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcga ccaagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctac agccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctgg aactctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcg gcctgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaaga cctacacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtg gaatctaagtacggccctccctgccctccttgcccagcccctgaatttctgggcggacc ctccgtgttcctgttccccccaaagcccaaggacaccctgatgatcagccggaccccc gaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattg gtacgtggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagt tcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaa cggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaa aaccatcagcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccc tagccaggaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttc taccccagcgacattgccgtggaatgggagagcaacggccagcccgagaacaacta caagaccaccccccctgtgctggacagcgacggctcattcttcctggtgtccaagctga ccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacg aggccctgcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcc SEQID agcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctg NO:421 agctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtcca acagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcac cctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccaggg cacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagcc caaggccgcccccgacttcgtgctgacccagagccctcacagcctgagcgtgacacc tggcgagagcgccagcatcagctgcaagagcagccactccctgatccacggcgacc ggaacaactacctggcttggtacgtgcagaagcccggcagatccccccagctgctgat ctacctggccagcagcagagccagcggcgtgcccgatagattttctggcagcggcag cgacaaggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcaccta ctactgtatgcagggcagagagagcccctggacctttggccagggcaccaaggtgga catcaagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttccca cctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaactt ctacccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggca acagccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagc agcaccctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcga agtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtg t BindingProtein47AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn SEQID vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg NO:422 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq prepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:423 fppsdeqlksgtasvycllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthgglsspvtksfnrgec HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg SEQID wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh NO:424 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtqvqlvesg ggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaqikdksnsy atyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdyw gqgtlvtvssdkthtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvs wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc avkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwq egnvfscsvmhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth NO:425 tdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein47NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg SEQID tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag NO:426 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg SEQID accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa NO:427 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaag SEQID gtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgca NO:428 gcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaag aaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcacc aacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactactg cgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggcg ccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccaggg cacagccgtgaccgtgtcatctgacaaaacccatacccaggtgcagctggtggaatctg gcggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtacta tgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgataa gacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagcaga agcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagc ccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagcc gtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagca gcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaagg tggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaa tttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatc agccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgag gtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccca gagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcacca ggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccag ctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtg taccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg gcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca SEQID gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga NO:429 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaaccc ataccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagag cgccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggcca gcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggact tcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgca gggcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggataa gacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagc agctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgag gccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgaca ctgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccag ggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein48AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrqapgqglewigsiypgn SEQID vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg NO:430 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq prepqvytippcqeemtknqvslwclvkgfypsdiavewesngqpennykttpp vldsdgsfflyskltydksrwqegnvfscsvmhealhnhytqksislslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:431 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq SEQID ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy NO:432 alspfdywgqgtlvtvsssqvhltqsgpevrkpgtsvkvsckapgntlktydl hwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntaylqls gltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwgqgt avtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs vmhealhnhytqkslslslgk LightchainB Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr SEQID asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikgqp NO:433 kaapdivmtqtplslsvtpgqpasisckssqslvhnnantylswylakpgqspqsliy kvsnrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikt kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein48NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg SEQID tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag NO:434 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatccagatgacccagagccccagcagcctgtctgccagcggggcgacagagtg SEQID accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa NO:435 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga SEQID ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc NO:436 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac cctcgtgaccgtgtctagtagccaggtgcacctgacacagagcggacccgaagtgcg gaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaacaccctgaaaacc tacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtggatgggctgg atcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgacc atcgactgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctg gcgataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaa cctggaattctggggccagggcacagccgtgaccgtgtcatctcggaccgccagcaca aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac tctggcgctctgacaagggcgtgcacacctttccagccgtgctccagagcagcggcc tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta cacctgtaacgtggaccacaagcccagcaacaccaaggggacaagcgggtggaatc taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt gttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag gaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccca gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct gcacaaccactacacccagaagtccctctctcttccctgggcaag LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc SEQID agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg NO:437 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagggccag cccaaggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtgaca cctggacagcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaac gccaacacctacctgagctggtatctgcagaagcccggccagagcccccagtccctga tctacaaggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctct ggcaccgacttcaccctgaagatcagccgggtggaagccgaggacgtgggcgtgtac tattgtggccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaat caagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacct agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttcta cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein49AminoAcidSequences HeavychainA Qvqlvqsgaevvkpgasvkvsckasgytftsyyihwvrgapgqglewigsiypgn SEQID vntnyaqkfqgratltvdtsistaymelsrlrsddtavyyctrshygldwnfdvwgkg NO:438 ttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtf pavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppcp apeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvevh naktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakgq prepqvytlppeqeemtknqvslwclvkgfypsdiavewesngqpennykttpp vldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Diqmtqspsslsasvgdrvtitcqasqniyvwlnwyqqkpgkapklliykasnlht SEQID gvpsrfsgsgsgtdftltisslqpediatyycqqgqtypytfgqgtkleikrtvaapsvfi NO:439 fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys lsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq SEQID ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy NO:440 alspfdywgqgtlvtvssdkthtqvhltqsgpevrkpgtsvkvsckapgntlk tydlhwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntay lqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwg qgtavtvssdkthtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvs wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc avkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwq egnvfscsvmhealhnhytqkslslslgk LightchainB Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr SEQID asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth NO:441 tdivmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein49NucleotideSequences HeavychainA caggtgcagctggtgcagtctggcgccgaggtcgtgaaacctggcgcctctgtgaagg SEQID tgtcctgcaaggccagcggctacacctttaccagctactacatccactgggtgcgccag NO:442 gcccctggacagggactggaatggatcggcagcatctaccccggcaacgtgaacacc aactacgcccagaagttccagggcagagccaccctgaccgtggacaccagcatcagc accgcctacatggaactgagccggctgagaagcgacgacaccgccgtgtactactgc acccggtcccactacggcctggattggaacttcgacgtgtggggcaagggcaccacc gtgacagtgtctagcgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatccagatgacccagagccccagcagcctgtctgccagcgtgggcgacagagtg SEQID accatcacctgtcaggccagccagaacatctacgtgtggctgaactggtatcagcagaa NO:443 gcccggcaaggcccccaagctgctgatctacaaggccagcaacctgcacaccggcgt gcccagcagattttctggcagcggctccggcaccgacttcaccctgacaatcagctccc tgcagcccgaggacattgccacctactactgccagcagggccagacctacccctacac ctttggccagggcaccaagctggaaatcaagcgtacggtggccgctcccagcgtgttc atcttcccacctagcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgct gaacaacttctacccccgcgaggccaaggtgcagtggaaggtggacaatgccctgca gagcggcaacagccaggaaagcgtgaccgagcaggacagcaaggactccacctac agcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtac gcctgcgaagtgacccaccagggcctgtctagccccgtgaccaagagcttcaaccgg ggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga SEQID ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc NO:444 aggcccctggaaagcagctggaatgggggcccagatcaaggacaagagcaacagc tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac agcaagaacaccctgtacctgcagatgaacagcctggggccgaggacaccgccgtg tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac cctcgtgaccgtgtctagtgacaaaacccatacccaggtgcacctgacacagagcgga cccgaagtgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaaca ccctgaaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagt ggatgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaagg ccaaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagcg gcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcaccggct gagagactacgccctgtacgacgatgacggcgccctgaactgggccgtggatgtgga ctacctgagcaacctggaattctggggccagggcacagccgtgaccgtgtcatctgata agacccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcagcag aagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgag cccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagc cgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagc agcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaag gtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctga atttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgat cagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccga ggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcc cagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgccc agctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagt gtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccag cccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct ggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctg ctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccct gggcaag LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc SEQID agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg NO:445 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg gcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggacaaa acccataccgacatcgtgatgacccagacccccctgagcctgagcgtgacacctggac agcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaacgccaaca cctacctgagctggtatctgcagaagcccggccagagcccccagtccctgatctacaa ggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctctggcacc gacttcaccctgaagatcagccgggggaagccgaggacgtgggcgtgtactattgtg gccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagg ataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgac gagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein50AminoAcidSequences HeavychainA Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg SEQID tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq NO:446 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpcvqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwelvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltydksrwqcgnvfscsvmhealhnhytqkslslslgk LightchainA Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa NO:447 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg SEQID wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh NO:448 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvsssqvqlvesgggv vqpgrslrlscaasgftftkawmhwvrqapgkqlewvaqikdksnsyatyy adsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdywgqgt lvtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs vmhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikgqp NO:449 kaapdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliyl assrasgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikt kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspytksfnrgec BindingProtein50NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc SEQID tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca NO:450 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc agagacaagggctacagctactactacagcatggactactggggccagggcaccacc gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:451 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagatittccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacaccittggccagggcaccaagctggaaatcaagcgtacggtggccgc tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaag SEQID gtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgca NO:452 gcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaag aaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcacc aacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactactg cgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggcg ccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccaggg cacagccgtgaccgtgtcatcttctcaggtgcagctggtggaatctggcggcggagtg gtgcagcctggcagaagcctgagactgagctgtgccgccagcggcttcaccttcacca aggcctggatgcactgggtgcgccaggcccctggaaagcagctggaatgggtggccc agatcaaggacaagagcaacagctacgccacctactacgccgacagcgtgaagggc cggttcaccatcagccgggacgacagcaagaacaccctgtacctgcagatgaacagc ctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtactatgccctgagcc ccttcgattactggggccagggaaccctcgtgaccgtgtctagtcggaccgcttcgacc aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta cacctgtaacgtggaccacaagcccagcaacaccaaggiggacaagcgggtggaatc taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt gttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag gaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccca gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct gcacaaccactacacccagaagtccctgtctctgtccctgggcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca SEQID gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga NO:453 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagggccagccca aggccgcccccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctg gcgagagcgccagcatcagctgcaagagcagccactccctgatccacggcgaccgg aacaactacctggcttggtacgtgcagaagcccggcagatccccccagctgctgatcta cctggccagcagcagagccagcggcgtgcccgatagattttctggcagcggcagcga caaggacttcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctacta ctgtatgcagggcagagagagcccctggacctttggccagggcaccaaggtggacat caagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacct agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttcta cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein51AminoAcidSequences HeavychainA Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg SEQID tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq NO:454 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Divltqspaslavspggratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa NO:455 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk dstyslsstltlskadyckhkvyacevthqglsspvtksfnrgec HeavychainB Qvhltqsgpevrkpgtsvkvsckapgntlktydlhwvrsvpgqglqwmg SEQID wishegdkkviverfkakvtidwdrstntaylqlsgltsgdtavyycakgskh NO:456 rlrdyalydddgalnwavdvdylsnlefwgqgtavtvssdkthtqvqlvesg ggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaqikdksnsy atyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyyalspfdyw gqgtlvtvssdkthtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvs wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc avkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwq egnvfscsymhealhnhytqkslslslgk LightchainB Divmtqtplslsvtpgqpasisckssqslvhnnantylswylqkpgqspqsliykvs SEQID nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth NO:457 tdfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein51NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc SEQID tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca NO:458 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc agagacaagggctacagctactactacagcatggactactggggccagggcaccacc gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggggaccctccgtgttctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:459 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccgc tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB caggtgcacctgacacagagcggacccgaagtgcggaagcctggcacctctgtgaag SEQID gtgtcctgcaaggcccctggcaacaccctgaaaacctacgacctgcactgggtgcgca NO:460 gcgtgccaggacagggactgcagtggatgggctggatcagccacgagggcgacaag aaagtgatcgtggaacggttcaaggccaaagtgaccatcgactgggacagaagcacc aacaccgcctacctgcagctgagcggcctgacctctggcgataccgccgtgtactactg cgccaagggcagcaagcaccggctgagagactacgccctgtacgacgatgacggcg ccctgaactgggccgtggatgtggactacctgagcaacctggaattctggggccaggg cacagccgtgaccgtgtcatctgacaaaacccatacccaggtgcagctggtggaatctg gcggcggagtggtgcagcctggcagaagcctgagactgagctgtgccgccagcggc ttcaccttcaccaaggcctggatgcactgggtgcgccaggcccctggaaagcagctgg aatgggtggcccagatcaaggacaagagcaacagctacgccacctactacgccgaca gcgtgaagggccggttcaccatcagccgggacgacagcaagaacaccctgtacctgc agatgaacagcctgcgggccgaggacaccgccgtgtactactgtcggggcgtgtacta tgccctgagccccttcgattactggggccagggaaccctcgtgaccgtgtctagtgataa gacccacaccgcttcgaccaagggcccatcggtgttccctctggccccttgcagcaga agcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgagc ccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagcc gtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagca gcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaagg tggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctgaa tttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgatc agccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcccgag gtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagccca gagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcacca ggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgcccag ctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagtgtg taccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgtgcc gtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccagccc gagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcctggt gtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctgctc cgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccctgg gcaag LightchainB gacatcgtgatgacccagacccccctgagcctgagcgtgacacctggacagcctgcca SEQID gcatcagctgcaagagcagccagagcctggtgcacaacaacgccaacacctacctga NO:461 gctggtatctgcagaagcccggccagagcccccagtccctgatctacaaggtgtccaa cagattcagcggcgtgcccgacagattctccggcagcggctctggcaccgacttcacc ctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtggccagggc acccagtaccccttcacctttggcagcggcaccaaggtggaaatcaaggacaaaaccc ataccgacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagag cgccagcatcagctgcaagagcagccactccctgatccacggcgaccggaacaacta cctggcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggcca gcagcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggact tcaccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgca gggcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggataa gacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgacgagc agctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccgcgag gccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaa gcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgaca ctgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccaccag ggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein52AminoAcidSequences HeavychainA Qvqlqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg SEQID tnynpslksrktiskdtsknqyslklssvtaadtavyycardkgysyyysmdywgq NO:462 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltydksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa NO:463 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvqlvesgggvvqpgrslrlscaasgftftkawmwvrqapgkqlewvaq SEQID ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy NO:464 alspfdywgqgtlvtvsssqvhltqsgpevrkpgtsvkvsckapgntlktydl hwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntaylqls gltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwgqgt avtvssrtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgalt sgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrvesk ygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpe vqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwlngkeykck vsnkglpssiektiskakgqprepqvctlppsqeemtknqvslscavkgfyp sdiavewesngqpennykttppvldsdgsfflvskltvdksrwqegnvfscs vmhealhnhytqkslslslgk LightchainB Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr SEQID asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikgqp NO:465 kaapdivmtqtplslsvtpgqpasisckssqslvhnnantylswylakpgqspqsliy kvsnrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikt kgpsrtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsq esvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein52NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc SEQID tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca NO:466 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggggaggcaccaa ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc agagacaagggctacagctactactacagcatggactactggggccagggcaccacc gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaaggggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:467 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccgc tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga SEQID ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc NO:468 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac cctcgtgaccgtgtctagtagccaggtgcacctgacacagagcggacccgaagtgcg gaagcctggcacctctgtgaaggtgtctgcaaggcccctggcaacaccctgaaaacc tacgacctgcactgggtgcgcagcgtgccaggacagggactgcagtggatgggctgg atcagccacgagggcgacaagaaagtgatcgtggaacggttcaaggccaaagtgacc atcgactgggacagaagcaccaacaccgcctacctgcagctgagcggcctgacctctg gcgataccgccgtgtactactgcgccaagggcagcaagcaccggctgagagactacg ccctgtacgacgatgacggcgccctgaactgggccgtggatgtggactacctgagcaa cctggaattctggggccagggcacagccgtgaccgtgtcatctcggaccgccagcaca aagggcccatcggtgttccctctggccccttgcagcagaagcaccagcgaatctacag ccgccctgggctgcctcgtgaaggactactttcccgagcccgtgaccgtgtcctggaac tctggcgctctgacaagcggcgtgcacacctttccagccgtgctccagagcagcggcc tgtactctctgagcagcgtcgtgacagtgcccagcagcagcctgggcaccaagaccta cacctgtaacgtggaccacaagcccagcaacaccaaggtggacaagcgggtggaatc taagtacggccctccctgccctccttgcccagcccctgaatttctgggcggaccctccgt gttcctgttccccccaaagcccaaggacaccctgatgatcagccggacccccgaagtg acctgcgtggtggtggatgtgtcccaggaagatcccgaggtgcagttcaattggtacgt ggacggcgtggaagtgcacaacgccaagaccaagcccagagaggaacagttcaaca gcacctaccgggtggtgtccgtgctgaccgtgctgcaccaggactggctgaacggcaa agagtacaagtgcaaggtgtccaacaagggcctgcccagctccatcgagaaaaccatc agcaaggccaagggccagccccgcgagcctcaagtgtgtaccctgccccctagccag gaagagatgaccaagaaccaggtgtccctgagctgtgccgtgaaaggcttctacccca gcgacattgccgtggaatgggagagcaacggccagcccgagaacaactacaagacc accccccctgtgctggacagcgacggctcattcttcctggtgtccaagctgaccgtgga caagagccggtggcaggaaggcaacgtgttcagctgctccgtgatgcacgaggccct gcacaaccactacacccagaagtccctgtctctctccctgggcaag LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc SEQID agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg NO:469 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg gcagagagagcccctggacctttggccagggcaccaaggtggacatcaagggccag cccaaggccgcccccgacatcgtgatgacccagacccccctgagcctgagcgtgaca cctggacagcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaac gccaacacctacctgagctggtatctgcagaagcccggccagagcccccagtccctga tctacaaggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctct ggcaccgacttcaccctgaagatcagccgggtggaagccgaggacgtgggcgtgtac tattgtggccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaat caagaccaagggccccagccgtacggtggccgctcccagcgtgttcatcttcccacct agcgacgagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttcta cccccgcgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaaca gccaggaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagc accctgacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtg acccaccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt BindingProtein53AminoAcidSequences HeavychainA Qvglqesgpglvkpsqtlsltctvsgfslsdygvhwvrqppgkglewlgviwaggg SEQID tnynpslksrktiskdtsknqvslklssvtaadtavyycardkgysyyysmdywgq NO:470 gttvtvssastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvht fpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkvdkrveskygppcppc papeflggpsvflfppkpkdtlmisrtpevtcvvvdvsqedpevqfnwyvdgvev hnaktkpreeqfnstyrvvsvltvlhqdwlngkeykckvsnkglpssiektiskakg qprepqvytlppcqeemtknqvslwclvkgfypsdiavewesngqpennykttp pvldsdgsfflyskltvdksrwqegnvfscsvmhealhnhytqkslslslgk LightchainA Divltqspaslavspgqratitcrasesveyyvtslmqwyqqkpgqppkllifaasn SEQID vesgvparfsgsgsgtdftltinpveandvanyycqqsrkvpytfgqgtkleikrtvaa NO:471 psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec HeavychainB Qvqlvesgggvvqpgrslrlscaasgftftkawmhwvrqapgkqlewvaq SEQID ikdksnsyatyyadsvkgrftisrddskntlylqmnslraedtavyycrgvyy NO:472 alspfdywgqgtlvtvssdkthtqvhltqsgpevrkpgtsvkvsckapgntlk tydlhwvrsvpgqglqwmgwishegdkkviverfkakvtidwdrstntay lqlsgltsgdtavyycakgskhrlrdyalydddgalnwavdvdylsnlefwg qgtavtvssdkthtastkgpsvfplapcsrstsestaalgclvkdyfpepvtvs wnsgaltsgvhtfpavlqssglyslssvvtvpssslgtktytcnvdhkpsntkv dkrveskygppcppcpapeflggpsvflfppkpkdtlmisrtpevtcvvvd vsqedpevqfnwyvdgvevhnaktkpreeqfnstyrvvsvltvlhqdwln gkeykckvsnkglpssiektiskakgqprepqvctlppsqeemtknqvslsc avkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksrwq egnvfscsvmhealhnhytqkslslslgk LightchainB Dfvltqsphslsvtpgesasiscksshslihgdrnnylawyvqkpgrspqlliylassr SEQID asgvpdrfsgsgsdkdftlkisrvetedvgtyycmqgrespwtfgqgtkvdikdkth NO:473 tdivmtqtplslsvtpgqpasisckssqslvhnnantylswylakpgqspqsliykvs nrfsgvpdrfsgsgsgtdftlkisrveaedvgvyycgqgtqypftfgsgtkveikdkth trtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvt eqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec BindingProtein53NucleotideSequences HeavychainA caggtgcagctgcaggaatctggccctggcctcgtgaagcctagccagaccctgagcc SEQID tgacctgtaccgtgtccggcttcagcctgagcgactacggcgtgcactgggtgcgcca NO:474 gccacctggaaaaggcctggaatggctgggcgtgatctgggctggcggaggcaccaa ctacaaccccagcctgaagtccagaaagaccatcagcaaggacaccagcaagaacca ggtgtccctgaagctgagcagcgtgacagccgccgataccgccgtgtactactgcgcc agagacaagggctacagctactactacagcatggactactggggccagggcaccacc gtgaccgtgtcatccgcgtcgaccaagggcccctcggtgttccctctggccccttgcag cagaagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttccc gagcccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttcc agccgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagc agcagcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacacc aaggtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagccc ctgaatttctgggcggaccctccgtgttcctgttccccccaaagcccaaggacaccctga tgatcagccggacccccgaagtgacctgcgtggtggtggatgtgtcccaggaagatcc cgaggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaa gcccagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctg caccaggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctg cccagctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctca agtgtataccctgcccccttgccaggaagagatgaccaagaaccaggtgtccctgtggt gtctcgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggcca gcccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttc ctgtactccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagct gctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtcc ctgggcaag LightchainA gacatcgtgctgacacagagccctgctagcctggccgtgtctcctggacagagggcca SEQID ccatcacctgtagagccagcgagagcgtggaatattacgtgaccagcctgatgcagtg NO:475 gtatcagcagaagcccggccagccccccaagctgctgattttcgccgccagcaacgtg gaaagcggcgtgccagccagattttccggcagcggctctggcaccgacttcaccctga ccatcaaccccgtggaagccaacgacgtggccaactactactgccagcagagccgga aggtgccctacacctttggccagggcaccaagctggaaatcaagcgtacggtggccgc tcccagcgtgttcatcttcccacctagcgacgagcagctgaagtccggcacagcctctgt cgtgtgcctgctgaacaacttctacccccgcgaggccaaggtgcagtggaaggtggac aatgccctgcagagcggcaacagccaggaaagcgtgaccgagcaggacagcaagg actccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagc acaaggtgtacgcctgcgaagtgacccaccagggcctgtctagccccgtgaccaaga gcttcaaccggggcgagtgt HeavychainB caggtgcagctggtggaatctggcggcggagtggtgcagcctggcagaagcctgaga SEQID ctgagctgtgccgccagcggcttcaccttcaccaaggcctggatgcactgggtgcgcc NO:476 aggcccctggaaagcagctggaatgggtggcccagatcaaggacaagagcaacagc tacgccacctactacgccgacagcgtgaagggccggttcaccatcagccgggacgac agcaagaacaccctgtacctgcagatgaacagcctgcgggccgaggacaccgccgtg tactactgtcggggcgtgtactatgccctgagccccttcgattactggggccagggaac cctcgtgaccgtgtctagtgacaaaacccatacccaggtgcacctgacacagagcgga cccgaagtgcggaagcctggcacctctgtgaaggtgtcctgcaaggcccctggcaaca ccctgaaaacctacgacctgcactgggtgcgcagcgtgccaggacagggactgcagt ggatgggctggatcagccacgagggcgacaagaaagtgatcgtggaacggttcaagg ccaaagtgaccatcgactgggacagaagcaccaacaccgcctacctgcagctgagcg gcctgacctctggcgataccgccgtgtactactgcgccaagggcagcaagcaccggct gagagactacgccctgtacgacgatgacggcgccctgaactgggccgtggatgtgga ctacctgagcaacctggaattctggggccagggcacagccgtgaccgtgtcatctgata agacccacaccgccagcacaaagggcccatcggtgttccctctggccccttgcagcag aagcaccagcgaatctacagccgccctgggctgcctcgtgaaggactactttcccgag cccgtgaccgtgtcctggaactctggcgctctgacaagcggcgtgcacacctttccagc cgtgctccagagcagcggcctgtactctctgagcagcgtcgtgacagtgcccagcagc agcctgggcaccaagacctacacctgtaacgtggaccacaagcccagcaacaccaag gtggacaagcgggtggaatctaagtacggccctccctgccctccttgcccagcccctga atttctgggggaccctccgtgttcctgttccccccaaagcccaaggacaccctgatgat cagccggacccccgaagtgacctggtggtggtggatgtgtcccaggaagatcccga ggtgcagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcc cagagaggaacagttcaacagcacctaccgggtggtgtccgtgctgaccgtgctgcac caggactggctgaacggcaaagagtacaagtgcaaggtgtccaacaagggcctgccc agctccatcgagaaaaccatcagcaaggccaagggccagccccgcgagcctcaagt gtgtaccctgccccctagccaggaagagatgaccaagaaccaggtgtccctgagctgt gccgtgaaaggcttctaccccagcgacattgccgtggaatgggagagcaacggccag cccgagaacaactacaagaccaccccccctgtgctggacagcgacggctcattcttcct ggtgtccaagctgaccgtggacaagagccggtggcaggaaggcaacgtgttcagctg ctccgtgatgcacgaggccctgcacaaccactacacccagaagtccctgtctctgtccct gggcaag LightchainB gacttcgtgctgacccagagccctcacagcctgagcgtgacacctggcgagagcgcc SEQID agcatcagctgcaagagcagccactccctgatccacggcgaccggaacaactacctg NO:477 gcttggtacgtgcagaagcccggcagatccccccagctgctgatctacctggccagca gcagagccagcggcgtgcccgatagattttctggcagcggcagcgacaaggacttca ccctgaagatcagccgggtggaaaccgaggacgtgggcacctactactgtatgcagg gcagagagagcccctggacctttggccagggcaccaaggtggacatcaaggacaaa acccataccgacatcgtgatgacccagacccccctgagcctgagcgtgacacctggac agcctgccagcatcagctgcaagagcagccagagcctggtgcacaacaacgccaaca cctacctgagctggtatctgcagaagcccggccagagcccccagtccctgatctacaa ggtgtccaacagattcagcggcgtgcccgacagattctccggcagcggctctggcacc gacttcaccctgaagatcagccgggtggaagccgaggacgtgggcgtgtactattgtg gccagggcacccagtaccccttcacctttggcagcggcaccaaggtggaaatcaagg ataagacccatacccgtacggtggccgctcccagcgtgttcatcttcccacctagcgac gagcagctgaagtccggcacagcctctgtcgtgtgcctgctgaacaacttctacccccg cgaggccaaagtgcagtggaaggtggacaacgccctgcagagcggcaacagccag gaaagcgtgaccgagcaggacagcaaggactccacctacagcctgagcagcaccct gacactgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgaccca ccagggcctgtctagccccgtgaccaagagcttcaaccggggcgagtgt

    TABLE-US-00012 TABLEA CDRsequencesofbindingproteins AB CDRH1 CDRH2 CDRH3 CDRL1 CDRL2 CDRL3 CD4BSa dctln wlkprggavnyarplqg gkncdynwdfeh rtsqygsla sgstraa qqyef (SEQIDNO:248) (SEQIDNO:249) (SEQIDNO:250) (SEQIDNO:266) (SEQIDNO:267 (SEQIDNO:268) CD4BSb GYTFTAHI IKPQYGAV drsygdsswalda QGVGSD HTS qvlqf (SEQIDNO:251) (SEQIDNO:252) (SEQIDNO:253) (SEQIDNO:269) (SEQIDNO:271) MPER gfdfdnaw itgpgegwsv tgkyydfwsgyppgeeyfqd rgdslrshyas gknnrps ssrdksgsrlsv (SEQIDNO:254) (SEQIDNO:255) (SEQIDNO:256) (SEQIDNO:272) (SEQIDNO:273) (SEQIDNO:274) V1/V2dir. GNTLKTYD ISHEGDKK cakgskhrlrdyalydddgaln hslihgdrnny LAS cmqgrespwtf a (SEQIDNO:257) (SEQIDNO:258) wavdvdylsnlefw (SEQIDNO:275) (SEQIDNO:277) (SEQIDNO:259) V3dir. SGASISDSY VHKSGDT ARTLHGRRIYGIVAF SLGSRA NNQ HIWDSRVPTKWV (SEQIDNO:260) (SEQIDNO:261) NEWFTYFYMDV (SEQIDNO:278) (SEQIDNO:280) (SEQIDNO:262) V1/Vdir. QFRFDGYG ISHDGIKK CAKDLREDECEEW TSNIGNNF ETD atwaaslssarv b (SEQIDNO:263) (SEQIDNO:264) WSDYYDFGKQLPCA (SEQIDNO:281) (SEQIDNO:283) KSRGGLVGIADNW (SEQIDNO:265) Anti-CD28 GYTFTSYY IYPGNVNT trshygldwnfdv QNIYVW KAS qqgqtvpyt (SEQIDNO:479) (SEQIDNO:480) (SEQIDNO:481) (SEQIDNO:488) (SEQIDNO:490) Anti-CD28 GFSLSDYG IWAGGGT ardkgysyyysmd ESVEYYVTSL AAS qqsrkvpyt (SEQIDNO:482) (SEQIDNO:483) (SEQIDNO:484) (SEQIDNO:491) (SEQIDNO:493) Anti-CD3 GFTFTKAW IKDKSNS rgvyyalspfdy QSLVHNNANTY KVS gqgtqyp (SEQIDNO:485) (SEQIDNO:486) (SEQIDNO:487) (SEQIDNO:494) (SEQIDNO:496)

    TABLE-US-00013 TABLEB CDRsequencesofparentalantibodies Ab CDR_H1 CDR_H2 CDR_H3 CDR_L1 CDR_L2 CDR_L3 CD4BS DCTLN LKPRGGAVNYARP GKNCDYNWDFEH RTSQYGSLA SGSTRAA QQYEF a (SEQIDNO:248) LQ (SEQIDNO:250) (SEQIDNO:266) (SEQIDNO:267) (SEQIDNO:268) (SEQIDNO:497) CD4BS GYTFTAHI IKPQYGAV DRSYGDSSWALDA QGVGSD HTS QVLQF b (SEQIDNO:251) (SEQIDNO:252) (SEQIDNO:253) (SEQIDNO:269) (SEQIDNO:271) MPER GFDFDNAW ITGPGEGWSV TGKYYDFWSGYPPGEEYFQ SLRSHY GKN SSRDKSGSRLSV (SEQIDNO:254) (SEQIDNO:255) D (SEQIDNO:500) (SEQIDNO:274) (SEQIDNO:256) MPER_ GFDFDNAW ITGPGEGWSV TGKYYDFWWGYPPGEEYF SLRSHY GKN SSRDKSGSRLSV 100W (SEQIDNO:254) (SEQIDNO:255) QD (SEQIDNO:500) (SEQIDNO:274) (SEQIDNO:498) V1/V2 GNTLKTYD ISHEGDKK CAKGSKHRLRDYALYDDD HSLIHGDRNNY LAS CMQGRESPWTF directed (SEQIDNO:257) (SEQIDNO:258) GALNWAVDVDYLSNLEFW (SEQIDNO:275) (SEQIDNO:277) a (SEQIDNO:259) V1/V2 QFRFDGYG ISHDGIKK CAKDLREDECEEWWSDYY TSNIGNNF ETD ATWAASLSSAR directed (SEQIDNO:263) (SEQIDNO:264) DFGKQLPCAKSRGGLVGIA (SEQIDNO:281) V b DNW (SEQIDNO:283) (SEQIDNO:265) V3 GASISDSY VHKSGDT ARTLHGRRIYGIVAFNEWF SLGSRA NNQ HIWDSRVPTKW directed (SEQIDNO:499) (SEQIDNO:261) TYFYMDV (SEQIDNO:278) V (SEQIDNO:262) (SEQIDNO:280) CD28 GYTFTSYY IYPGNVNT TRSHYGLDWNFDV QNIYVW KAS QQGQTYPYT (SEQIDNO:479) (SEQIDNO:480) (SEQIDNO:481) (SEQIDNO;488) (SEQIDNO:490) CD28_2 GFSLSDYG IWAGGGT ARDKGYSYYYSMD ESVEYYVTSL AAS QQSRKVPYT (SEQIDNO:482) (SEQIDNO:483) (SEQIDNO:484) (SEQIDNO:491) (SEQIDNO:493) CD3 GFTFTKAW IKDKSNS RGVYYALSPFDY QSLVHNNANTY KVS GQGTQYP (SEQIDNO:485) (SEQIDNO:486) (SEQIDNO:487) (SEQIDNO:494) (SEQIDNO:496)

    TABLE-US-00014 TABLEC Variabledomainsequencesofparentalantibodies AbName V.sub.H V.sub.L CD4BSa QVQLVQSGGQMKKPGESMRISCRASGYEFIDCTLNWIRLAP EIVLTQSPGTLSLSPGETAIISCRTSQYGSLAWYQQ GKRPEWMGWLKPRGGAVNYARPLQGRVTMTRDVYSDTAF RPGQAPRLVIYSGSTRAAGIPDRFSGSRWGPDYNL LELRSLTVDDTAVYFCTRGKNCDYNWDFEHWGRGTPVIVS TISNLESGDFGVYYCQQYEFFGQGTKVQVDIK S (SEQIDNO:512) (SEQIDNO:502) CD4BSb RAHLVQSGTAMKKPGASVRVSCQTSGYTFTAHILFWFRQAP YIHVTQSPSSLSVSIGDRVTINCQTSQGVGSDLHW GRGLEWVGWIKPQYGAVNFGGGFRDRVTLTRDVYREIAY YQHKPGRAPKLLIHHTSSVEDGVPSRFSGSGFHTS MDIRGLKPDDTAVYYCARDRSYGDSSWALDAWGQGTTVV FNLTISDLQADDIATYYCQVLQFFGRGSRLHIK VSA (SEQIDNO:513) (SEQIDNO:503) CD4BSb RAHLVQSGTAMKKPGASVRVSCQTSGYTFTAHILFWFRQAP YIHVTQSPSSLSVSIGDRVTINCQTSQGVGSDLHW (Aglycan) GRGLEWVGWIKPQYGAVNFGGGFRDRVTLTRDVYREIAY YQHKPGRAPKLLIHHTSSVEDGVPSRFSGSGFHTS MDIRGLKPDDTAVYYCARDRSYGDSSWALDAWGQGTTVV FQLTISDLQADDIATYYCQVLQFFGRGSRLHIK VSA (SEQIDNO:514) (SEQIDNO:503) CD4BSb RAHLVQSGTAMKKPGASVRVSCQTSGYTFTAHILFWFRQAP YIHVTQSPSSLSVSIGDRVTINCQTSQGVGSDLHW (Aiso- GRGLEWVGWIKPQYGAVNFGGGFRDRVTLTRDVYREIAY YQHKPGRAPKLLIHHTSSVEEGVPSRFSGSGFHTS merization MDIRGLKPDDTAVYYCARDRSYGDSSWALDAWGQGTTVV FNLTISDLQADDIATYYCQVLQFFGRGSRLHIK D55E) VSA (SEQIDNO:515) (SEQIDNO:503) CD4BSb RAHLVQSGTAMKKPGASVRVSCQTSGYTFTAHILFWFRQAP YIHVTQSPSSLSVSIGDRVTINCQTSQGVGSDLHW (Aiso- GRGLEWVGWIKPQYGAVNFGGGFRDRVTLTRDVYREIAY YQHKPGRAPKLLIHHTSSVEDAVPSRFSGSGEHTS merization MDIRGLKPDDTAVYYCARDRSYGDSSWALDAWGOGTTVV FNLTISDLQADDIATYYCQVLQFFGRGSRLHIK G56A) VSA (SEQIDNO:516) (SEQIDNO:503) CD4BSb RAHLVQSGTAMKKPGASVRVSCQTSGYTFTAHILFWFRQAP YIHVTQSPSSLSVSIGDRVTINCQTSQGVGSDLHW (Aglycan/ GRGLEWVGWIKPQYGAVNFGGGFRDRVTLTRDVYREIAY YQHKPGRAPKLLIHHTSSVEEGVPSRFSGSGEHTS Aisomerization MDIRGLKPDDTAVYYCARDRSYGDSSWALDAWGQGTTVV FQLTISDLQADDIATYYCQVLQFFGRGSRLHIK D55E) VSA (SEQIDNO:517) (SEQIDNO:503) MPER EVRLVESGGGLVKPGGSLRLSCSASGFDFDNAWMTWVRQP ASELTQDPAVSVALKQTVTITCRGDSLRSHYASW PGKGLEWVGRITGPGEGWSVDYAESVKGRFTISRDNTKNTL YQKKPGQAPVLLFYGKNNRPSGIPDRFSGSASGN YLEMNNVRTEDTGYYFCARTGKYYDFWSGYPPGEEYFQD RASLTITGAQAEDEADYYCSSRDKSGSRLSVFGG WGQGTLVIVSS GTKLTVL (SEQIDNO:504) (SEQIDNO:518) MPER_100W EVRLVESGGGLVKPGGSLRLSCSASGFDFDNAWMTWVRQP ASELTQDPAVSVALKQTVTITCRGDSLRSHYASW PGKGLEWVGRITGPGEGWSVDYAESVKGRFTISRDNTKNTL YQKKPGQAPVLLFYGKNNRPSGIPDRFSGSASGN YLEMNNVRTEDTGYYFCARTGKYYDFWWGYPPGEEYFQD RASLTITGAQAEDEADYYCSSRDKSGSRLSVFGG WGQGTLVIVSS GTKLTVL (SEQIDNO:505) (SEQIDNO:518) V1/V2 QVHLTQSGPEVRKPGTSVKVSCKAPGNTLKTYDLHWVRSV DFVLTQSPHSLSVTPGESASISCKSSHSLIHGDRNN directeda PGQGLQWMGWISHEGDKKVIVERFKAKVTIDWDRSTNTAY YLAWYVQKPGRSPQLLIYLASSRASGVPDRFSGS LQLSGLTSGDTAVYYCAKGSKHRLRDYALYDDDGALNWA GSDKDFTLKISRVETEDVGTYYCMQGRESPWTFG VDVDYLSNLEFWGQGTAVTVSS QGTKVDIK (SEQIDNO:506) (SEQIDNO:519) V1/V2 QVQLVESGGGVVQPGTSLRLSCAASQFRFDGYGMHWVRQ QSVLTQPPSVSAAPGQKVTISCSGNTSNIGNNFVS directedb APGKGLEWVASISHDGIKKYHAEKVWGRFTISRDNSKNTLY WYQQRPGRAPQLLIYETDKRPSGIPDRFSASKSGT LQMNSLRPEDTALYYCAKDLREDECEEWWSDYYDFGKQLP SGTLAITGLQTGDEADYYCATWAASLSSARVFGT CAKSRGGLVGIADNWGQGTMVTVSS GTKVIVL (SEQIDNO:507) (SEQIDNO:520) V3directed QMQLQESGPGLVKPSETLSLTCSVSGASISDSYWSWIRRSP SDISVAPGETARISCGEKSLGSRAVQWYQHRAGQ GKGLEWIGYVHKSGDTNYSPSLKSRVNLSLDTSKNQVSLSL APSLIIYNNQDRPSGIPERFSGSPDSPFGTTATLTI VAATAADSGKYYCARTLHGRRIYGIVAFNEWFTYFYMDVW TSVEAGDEADYYCHIWDSRVPTKWVFGGGTTLTV GNGTQVTVSS L (SEQIDNO:508) (SEQIDNO:521) CD28 QVQLVQSGAEVVKPGASVKVSCKASGYTFTSYYIHWVRQA DIQMTQSPSSLSASVGDRVTITCQASQNIYVWLN PGQGLEWIGSIYPGNVNTNYAQKFQGRATLTVDTSISTAYM WYQQKPGKAPKLLIYKASNLHTGVPSRFSGSGSG ELSRLRSDDTAVYYCTRSHYGLDWNFDVWGKGTTVTVSS TDFTLTISSLQPEDIATYYCQQGQTYPYTFGQGTK (SEQIDNO:509) LEIK (SEQIDNO:522) CD28_2 QVQLQESGPGLVKPSQTLSLTCTVSGFSLSDYGVHWVRQPP DIVLTQSPASLAVSPGQRATITCRASESVEYYVTS GKGLEWLGVIWAGGGTNYNPSLKSRKTISKDTSKNQVSLKL LMQWYQQKPGQPPKLLIFAASNVESGVPARFSGS SSVTAADTAVYYCARDKGYSYYYSMDYWGQGTTVTVSS GSGTDFTLTINPVEANDVANYYCQQSRKVPYTFG (SEQIDNO:510) QGTKLEIK (SEQIDNO:523) CD3 QVQLVESGGGVVQPGRSLRLSCAASGFTFTKAWMHWVRQ DIVMTQTPLSLSVTPGQPASISCKSSQSLVHNNAN APGKQLEWVAQIKDKSNSYATYYADSVKGRFTISRDDSKNT TYLSWYLQKPGQSPQSLIYKVSNRFSGVPDRFSGS LYLQMNSLRAEDTAVYYCRGVYYALSPFDYWGQGTLVTV GSGTDFTLKISRVEAEDVGVYYCGQGTQYPFTFG SS SGTKVEIK (SEQIDNO:511) (SEQIDNO:524) CDR sequences are underlined. Variable domain modifications are shown in bold and italicized.