NOVEL COMPOSITIONS

Abstract

The present invention relates to compositions containing at least one sunscreen active agent and having improved sun protection factor (SPF) properties, as well as methods of improving sun protection factor (SPF) properties.

Claims

1. A composition comprising at least one sunscreen active agent absorbing light in the UVB or the UVA-range and at least one neutral core human milk oligosaccharide composed of galactose, N-acetylglucosamine, and glucose monosaccharide.

2. The composition according to claim 1, wherein the at least one sunscreen active agent has a lambda max in the range of 280 to 400 nm.

3. The composition according to claim 1, wherein the at least one neutral core human milk oligosaccharide is selected from the group consisting of tri-, tetra-, hexa-, octa- or decasaccharides.

4. The composition according to claim 1, wherein the galactose, N-acetylglucosamine, and glucose monosaccharide are linked through -(1-3) or -(1-4) bonds with each other.

5. The composition according to claim 1, wherein the human milk oligosaccharide is selected from the group consisting of lacto-N-triose II, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose and para-lacto-N-neohexaose; or a mixture thereof.

6. The composition according to claim 1, wherein the at least one neutral core human milk oligosaccharide is present in an amount effective to increase SPF of the composition.

7. The composition according to claim 1, wherein the amount of the neutral core human milk oligosaccharide in the composition is at least 0.2 wt. %, based on the total weight of the composition.

8. The composition according to claim 1, wherein the at least one sunscreen active agent is an organic UV-filter or an inorganic UV-filter.

9. The composition according to claim 1, wherein the total amount of the at least one sunscreen active agents in the composition is selected in the range from 1 to 50 wt.-%, preferably from 3 to 40 wt.-%, most preferably from 5 to 30 wt.-%, based on the total weight of the composition.

10. The composition according to claim 1, wherein the composition comprises a carrier consisting of at least 30 wt. %, more preferably of at least 40 wt.-%, most preferably of at least 45 wt.-% of water, such as in particular of 50 to 90 wt.-% of water.

11. The composition according to claim 1, wherein the composition is an emulsion.

12. The composition according to claim 11, wherein, the composition is an O/W emulsion comprising an oily phase dispersed in an aqueous phase.

13. (canceled)

14. A method of preparing a composition comprising adding at least one sunscreen active agent and at least one neutral core human milk oligosaccharide composed of galactose, N-acetylglucosamine, and glucose monosaccharide to the composition.

15. (canceled)

16. The composition according to claim 5, lacto-N-triose II, wherein the human milk oligosaccharide is selected from the group consisting of lacto-N-tetraose and lacto-N-neotetraose.

17. The composition according to claim 7, wherein the amount of the neutral core human milk oligosaccharide in the composition is at least 0.5 wt.-%, based on the total weight of the composition.

18. The composition according to claim 8, wherein the organic UV-filter is selected from the group consisting of homosalate, ethylhexyl salicylate, polysilicone-15, ethylhexyl methoxycinnamate, octocrylene, phenylbenzimidazole sulphonic acid or a salt thereof, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylhexyl butamido triazone, methylene bisbenzotriazolyl tetramethylbutylphenol, tris-biphenyl triazine, butyl methoxydibenzoylmethane, and diethylamino hydroxybenzoyl hexyl benzoate.

19. The composition according to claim 8, wherein the inorganic UV-filter comprises titanium dioxide, zinc oxide, or a mixture thereof.

20. The composition according to claim 9, wherein the total amount of the at least one sunscreen active agent in the composition is selected in the range from 5 to 30 wt.-%, based on the total weight of the composition

21. The composition according to claim 10, wherein the composition comprises a carrier consisting of at least 45 wt.-% of water.

22. The composition according to claim 10, wherein the composition comprises a carrier consisting of 50 to 90 wt.-% of water.

Description

EXAMPLES

Short Description

[0146] The neutral core human milk oligosaccharides LNT and LNnT were evaluated for their SPF boosting effect. For this purpose various sunscreens were prepared according to standard methods in the art as outlined in tables 1a, 2a and 3a.

In Vitro SPF Measurement

[0147] The in vitro SPF test was performed on PMMA plates (HD6 plates from Helioscreen, 5 cm5 cm, roughness of Sa=6 m): 32.5 mg of the respective formulation (i.e. 1.3 mg/cm.sup.2) were applied homogenously onto the PMMA plates and dried for 15 minutes.

[0148] The in vitro SPF was determined using a Labsphere 2000 UV Transmittance Analyzer: each PMMA plate was measured 9 times at different points on the plate resulting in 27 data points. The result is calculated as the average of these 27 data points.

TABLE-US-00002 TABLE 1a Formulation 1 Conc. Trade name INCI name [wt.-%] Lexfilm Sun Natural Capryloyl Glycerin/Sebacic Acid 1.5 MB Copolymer Lanette O Cetearyl Alcohol 1.0 TEGIN M Pellets MB Glyceryl Stearate 0.4 AMPHISOL K Potassium Cetyl Phosphate 0.5 Cetiol B Dibutyl Adipate 9.5 DL-alpha-Tocopheryl Tocopheryl Acetate 0.5 Acetate Uvinul A Plus Diethylamino Hydroxybenzoyl Hexyl 5.0 Benzoate PARSOL EHT Ethylhexyl Triazone 1.5 PARSOL Shield Bis Ethylhexyloxyphenol 2.0 Methoxyphenyl Triazine PARSOL MCX Ethylhexyl Methoxycinnamate 4.0 PARSOL SLX Polysilicone-15 2.0 Uvasaorb HEB Diethylhexyl Butamido Triazone 1.5 X-Tend 226 Phenethyl Benzoate 5.5 Dermosoft GMCY Glyceryl Caprylate 0.5 MB TEGO CARE PBS 6 MB Polyglyceryl-6 Stearate; 4.0 Polyglyceryl-6 Behenate HMO See table 1b table 1b HYA-ACT TM M Sodium Hyaluronate 0.1 Phenethylalcohol Nat. Phenethyl Alcohol 1.0 PARSOL MAX Methylene Bis-Benzotriazolyl 4.0 Tetramethylbutylphenol; Aqua; Decyl Glucoside; Propylene Glycol; Xanthan Gum Water Dem Aqua Ad 100 Rheocare XGN XANTHAN GUM 0.4 TILAMAR PDO with PROPANEDIOL 2.0 NVISTA

TABLE-US-00003 TABLE 1b Results HMO Conc. HMO SPF in vitro SPF boosting Reference 64.1 Sialyllactose (3-SL)(Ref.) 1% 75.9 +18% Lacto-N-Neotetraose (LNnT) 1% 85.7 +34%

TABLE-US-00004 TABLE 2a Formulation 2 Conc. Trade name INCI name [wt.-%] AMPHISOL K Potassium Cetyl Phosphate 2.0 Lanette O Cetearyl Alcohol 3.0 PARSOL 1789 Butyl Methoxydibenzoyl Methane 4.0 PARSOL EHS Ethylhexyl Salicylate 5.0 PARSOL 340 Octocrylene 8.0 PARSOL SHIELD Bis Ethylhexyloxyphenol 1.5 Methoxyphenyl Triazine Finsolv TN C12-15 Alkyl Benzoate 3.0 Dub DIS Diisopropyl Sebacate 2.0 Myritol 318 Caprylic/Capric Triglyceride 10.0 WATER DEM. Aqua Ad 100 Edeta BD Disodium EDTA 0.2 Keltrol CG-T Xanthan Gum 0.2 Glycerin 99.5% Glycerin 3.0 Triethanolamine Care Triethanolamine 0.1 HMO See table 2b table 2b Euxyl PE 9010 Phenoxyethanol; Ethylhexylglycerin 1.0

TABLE-US-00005 TABLE 2b Results Conc. HMO HMO [wt.-%] SPF in vitro SPF boosting Reference 5.3 Fucosyllactose (2-FL) (Ref) 1% 10.0 +89% 3% 15.2 +187% Lacto-N-tetraose (LNT) 1% 15.6 +194%

TABLE-US-00006 TABLE 3a Formulation 3 Conc. Trade name INCI name [wt.-%] AMPHISOL K Potassium Cetyl Phosphate 2.0 Lanette O Cetearyl Alcohol 3.0 PARSOL 1789 Butyl Methoxydibenzoyl Methane 4.0 PARSOL EHS Ethylhexyl Salicylate 5.0 PARSOL 340 Octocrylene 8.0 PARSOL Bis Ethylhexyloxyphenol Methoxyphenyl 1.5 SHIELD Triazine Finsolv TN C12-15 Alkyl Benzoate 3.0 Dub DIS Diisopropyl Sebacate 2.0 Myritol 318 Caprylic/Capric Triglyceride 5.0 WATER DEM. Aqua Ad 100 Edeta BD Disodium EDTA 0.2 Keltrol CG-T Xanthan Gum 0.2 Glycerin 99.5% Glycerin 3.0 Triethanolamine Triethanolamine 1.3 Care PARSOL HS Phenylbenzimidazole Sulfonic Acid 2.0 WATER DEM. Aqua 10.0 HMO see table 3b table 3b Euxyl PE 9010 Phenoxyethanol; Ethylhexylglycerin 1.0

TABLE-US-00007 TABLE 3b Results Conc. HMO HMO [wt.-%] SPF in vitro SPF boosting Reference 11.4 Fucosyllactose (2-FL) (Ref) 1% 21.2 +86% 3% 23.3 +104% Lacto-N-tetraose (LNT) 1% 292. +156%

[0149] As shown in the tables 1b, 2b and 3b the neutral core human milk oligosaccharide composed of galactose, N-acetylglucosamine, and glucose monosaccharide boost the in vitro SPF between 34% and 194%.