COMPOSITION CONTAINING PLANT EXTRACTS

Abstract

The present invention relates to a composition comprising plant extracts. The composition according to the present invention has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in melanocytes of the skin, promotes skin regeneration and increases skin elasticity or reduces skin wrinkles by promoting collagen synthesis and inhibiting collagenase activity in fibroblasts of the skin, has an anti-inflammatory effect or a skin soothing effect by inhibiting NO generation, increases the amount of moisture in the skin and has a moisturizing effect by promoting generation of hyaluronic acid in fibroblasts, and has an antioxidant effect by scavenging free radicals. In addition, since the composition of the present invention exhibits a broad antibacterial effect against various bacteria, the composition may be used as a cosmetic composition, a pharmaceutical composition, a skin external preparation, or a food composition.

Claims

1.-7. (canceled)

8. A method of skin-moisturizing, which comprises applying a cosmetic composition comprising one or more plant extracts selected from the group consisting of Island thistle (scientific name: Cirsium nipponicum (Maxim.), Wild chervil (scientific name: Anthriscus sylvestris), Orange Daylily (scientific name: Hemerocallis fulva (L.) L.), and Ulleung goldenrod (scientific name: Solidago virgaurea) as active ingredients, to the skin.

9. The method according to claim 8, wherein plant extracts are substances extracted from plants using water, an organic solvent, or a mixture thereof.

10. The method according to claim 9, wherein the organic solvent is a low-grade alcohol having 1 to 6 carbon atoms, a polyhydric alcohol, a hydrocarbon-based solvent, or a mixture thereof.

11. The method according to claim 8, wherein, based on 100 parts by weight of the composition, the plant extracts are comprised in an amount of 0.0001 to 10 parts by weight.

12. A method of skin-moisturizing, which comprises applying a pharmaceutical composition comprising one or more plant extracts selected from the group consisting of island thistle (scientific name: Cirsium nipponicum (Maxim.), Wild chervil (scientific name: Anthriscus sylvestris), Orange Daylily (scientific name: Hemerocallis fulva (L.) L.)and Ulleung goldenrod (scientific name: Solidago virgaurea) as active ingredients, to the skin.

13. A method of skin-moisturizing, which comprises applying a skin external preparation comprising one or more plant extracts selected from the group consisting of Island thistle (scientific name: Cirsium nipponicum (Maxim.), Wild chervil (scientific name: Anthriscus sylvestris), Orange Daylily (scientific name: Hemerocallis fulva (L.) L.), and Ulleung goldenrod (scientific name: Solidago virgaurea) as active ingredients, to the skin.

14. A method of skin-moisturizing, which comprises applying a food composition comprising one or more plant extracts selected from the group consisting of Island thistle (scientific name: Cirsium nipponicum (Maxim.), Wild chervil (scientific name: Anthriscus sylvestris), Orange Daylily (scientific name: Hemerocallis fulva (L.) L.), and Ulleung goldenrod (scientific name: Solidago virgaurea) as active ingredients, to the skin.

Description

Modes for Carrying Out the Invention

PREPARATION EXAMPLE 1

Preparation of Plant Extracts

[0087] A 70% aqueous ethanol solution was added to the whole plant, roots, sterns, leaves, fruits, flowers, shoots, branches, bark, sap, bulbils, or seeds of each of plants 1 to 112. At this time, the 70% aqueous ethanol solution was added in a volume corresponding to 20 times the mass of each plant tissue. Then, extraction was performed at room temperature for 3 days, and then filtration under reduced pressure was performed. Then, the filtered extracts were concentrated and dried using a rotary evaporator (Buchi, Switzerland) to prepare plant extracts.

EXPERIMENTAL EXAMPLE 1

Effect of Reducing Total Amount of Melanin

[0088] After a sample was added to the culture medium of B-16 mouse melanoma cells, a whitening effect was confirmed by measuring the total amount of melanin at the cellular level (Lotan R., Lotan D. Cancer Res. 40:3345-3350, 1980), Before the experiment, toxicity evaluation was performed on mouse melanoma cells to select a concentration without toxicity, and then whitening evaluation was performed at the concentration.

[0089] The sample was added to the culture medium so that the final concentration is the treatment concentration shown in the table below. As a control, arbutin was added to the culture medium at a concentration of 200 ppm. B-16 melanoma cells treated with the sample or arbutin were cultured for 3 days.

[0090] Thereafter, the cells were removed from a culture vessel and centrifuged, 1 ml of sodium hydroxide solution (1N concentration) was added to the centrifuged cell pellet, heating was performed at 80° C. for 10 minutes to dissolve melanin, and using a spectrophotometer, absorbance at 400 nm was measured to measure the amount of melanin produced.

[0091] The amount of melanin was determined according to absorbance per unit cell number (1×10.sup.6 cells). In addition, based on a non-addition control group, the relative total amount of melanin in the experimental group treated with each sample was calculated as inhibition rate (%), and the results are summarized in the table below.

EXPERIMENTAL EXAMPLE 2

Effect of Promoting Synthesis of Type I Collagen in Human-Derived Fibroblasts

[0092] Each sample was added to the culture medium of human-derived fibroblasts to confirm the effect of promoting synthesis of type I collagen at the cellular level. Measurement of synthesized collagen was quantified using a Procollagen Type I C-Peptide Enzyme Immuno Assay KIT (PICP ETA kit). To measure the amount of synthesized collagen, each sample was added to a fibroblast culture medium (DMEM culture medium). After cell culture for 48 hours, the culture medium was taken, and the degree of synthesis of type I collagen at each concentration was measured at 450 nm using a spectrophotometer using the PICP ETA kit.

[0093] For comparison of the effects, a collagen synthesis level was measured in the same manner for the culture medium of untreated fibroblasts (negative control) and a sample (positive control) to which TGFb was added to a final concentration of 10 ppb. A collagen production increase rate was calculated as the ratio of relative collagen production to the negative control group, and the results are shown in the table below.

EXPERIMENTAL EXAMPLE 3

NO Generation Inhibitory Effect

[0094] To check the anti-inflammatory effect and skin trouble alleviation effect of each sample, an experiment was conducted to evaluate inhibition of nitric oxide (NO) formation by the GRIESS method using the RAW264.7 cell line (ATCC number: CRL-2278).

[0095] Specifically, RAW264.7 cells, which are macrophages of mice, were subcultured several times, and the cells were seeded at a cell density of 3×10.sup.5 cells per well in a 24-well plate, followed by cell culture for 24 hours. Then, the final concentration was replaced with the diluted cell medium as shown in the table below. At this time, as a positive control, the cells were treated with L-NG-monomethylarginine (L-NMMA), a NO-production inhibitor, to a final concentration of 5 ppm and cultured for 30 minutes. Then, the cells were treated with lipopolysaccharide (LPS) as a stimulus at a concentration of 1 μg/ml and cultured for 24 hours. 100 μl of the supernatant was transferred to a 96-well plate, 100 μl of a GRIESS solution was added thereto, and then reaction was performed at room temperature for 10 minutes. Then, absorbance at 540 tun was measured, and the NO inhibitory effect of each sample was determined based on the absorbance, and the results are shown in the table below

EXPERIMENTAL EXAMPLE 4

Evaluation of Hyaluronic Acid Synthesis Enhancement

[0096] Human-derived fibroblasts (human dermal fibroblasts) cultured in a DMEM culture medium containing 10% fetal bovine serum at a cell density of 1×10.sup.5 cells/mL, and 500 μl of the cell culture medium was added to each well of a 24-well plate. After incubation for 18 hours, the samples were diluted with a DMEM culture medium without fetal bovine serum, and each sample was added at the following concentrations. As a positive control, epidermal growth factor (EGF), which is known to promote hyaluronic acid production, was added at a concentration of 10 ppb. After incubation for 24 hours, the cell culture medium was recovered, and the concentration of hyaluronic acid was measured using a Hyaluronan ELISA kit (R&D Systems).

[0097] In addition, based on the hyaluronic acid concentration (100%) of a non-addition control group, the hyaluronic acid concentrations of the experimental groups treated with each sample were quantified, and the results are shown in the following table.

EXPERIMENTAL EXAMPLE 5

Antioxidant Effect—Free Radical Scavenging Rate

[0098] To confirm antioxidant activity, free radical scavenging activity was measured using DPPH. DPPH was purchased from Sigma Co., Ltd. (USA). First, a standard DPPH ethanol solution with a concentration of 1.5 mM (0.06 mg/ml) was prepared. Then, ethanol was added to each extract and ascorbic acid as a reference material, which is known as an antioxidant, to prepare samples at a concentration of 0.1%, and serial dilution was performed. Then, the sample and the standard DPPH solution were added in the same ratio and stirred, followed by reaction at 37° C. for 30 minutes. Then, absorbance was measured at 517 nm. At this time, addition of ethanol instead of the sample was used as a control. Free radical scavenging ability was measured by calculating IC50, which is half maximal inhibitory concentration, and the results are shown in the following table. IC50 is a general method of expressing free radical scavenging ability as the concentration of ascorbic acid and extract required to remove 50% of free radicals of a non-addition control group.

EXPERIMENTAL EXAMPLE 6

Antibacterial Effect—Minimum Inhibitory Concentration (MIC) Measurement Method

[0099] MICs were measured for fermented cultures of Staphylococcus aureus and Aspergillus niger.

[0100] MIC measurement for Staphylococcus aureus was performed using Mueller Hinton broth, an optimal culture medium, at a bacterial concentration of 10.sup.6 CFU/mL at 37° C. for 24 hours. MIC measurement for Aspergillus niger was performed using potato dextrose broth at a bacterial concentration of 10.sup.5 CFU/mL at 30° C. for 48 hours. The serial dilution method was used for both bacteria, and the MIC of fermentation culture was confirmed by visually comparing the turbidity between wells after the incubation was completed.

[0101] The minimum inhibitory concentration of each extract was expressed as % (w/v), and MIC (%) in each table means % (w/v) unless otherwise stated.

EXPERIMENTAL EXAMPLE 7

Antibacterial Effect Against Bacteria Causing Dental Caries and Periodontitis

[0102] Antibacterial activity experiment was performed to confirm the preventive or therapeutic effect on dental caries and periodontitis of each sample. To confirm the effect of inhibiting the growth of oral pathogens, an antibacterial activity test was conducted by using the paper disc test method using Streptococcus mutans, a representative bacterium that causes dental caries, and Porphyromonas gingivalis, a representative bacterium that causes periodontal diseases.

[0103] After increasing the activity of each oral pathogen under the optimal culture conditions shown in the table below, each pathogen was cultured in an optimal medium for about 4 to 6 hours so that the turbidity of the culture medium was set to Macfarland turbidity No. 0.5 (1.5×10.sup.8), and then 0.1 ml of each oral pathogen was spread evenly on a plate medium. Thereafter, each sample was added at a concentration of 10 mg/disc and left for 1 hour for absorption drying. Then, each oral pathogen was cultured at the optimum temperature for 24 to 48 hours, and then the size (diameter, mm) of a growth inhibition ring was measured.

TABLE-US-00001 TABLE 1 Strain Optimum conditions Gram Culture staining Strain name Temperature medium Traits Gram (+) Streptococcus 37° C. BHI Facultative mutans anaerobic Gram (−) Porphyromonas 37° C. TSA Hemin Anaerobic gingivalis Menadione medium

EXAMPLE 1

Island Thistle

[0104]

TABLE-US-00002 TABLE 2 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Anti- Size of growth Size of growth Conc. English oxidation Anti-bacteria inhibition ring inhibition ring No. Sample (ppm) Scientific name name IC50 (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 1 Island thistle Cirsium nipponicum Island thistle (Maxim) Makino Comparative Thistle 50 Cirsium Japonicum 4.23 MIC (%) Bacteria: 2 8.5 8.1 Example MIC (%) Fungi: 2 1-1 Whole plant 2 0.88 MIC (%) Bacteria: 0.5 21.9 15.1 10 MIC (%) Fungi: 0.5 50 1-2 Roots 2 0.96 MIC (%) Bacteria: 0.25 13.9 19.5 10 MIC (%) Fungi: 0.25 50 1-3 Stems 2 0.77 MIC (%) Bacteria: 0.5 24.1 16.1 10 MIC (%) Fungi: 0.5 50 1-4 Leaves 2 0.64 MIC (%) Bacteria: 0.5 27.8 17.9 10 MIC (%) Fungi: 0.5 50 1-5 Fruits 2 0.13 MIC (%) Bacteria: 0.125 22.8 19.0 10 MIC (%) Fungi: 0.125 50 1-6 Flowers 2 0.97 MIC (%) Bacteria: 0.0625 11.1 8.4 10 MIC (%) Fungi: 0.0625 50

TABLE-US-00003 TABLE 3 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Anti- Size of growth Size of growth oxidation Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name IC50 (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 1 Island thistle Cirsium nipponicum Island thistle (Maxim.) Makino Comparative Thistle Cirsium Japonicum 4.23 MIC (%) Bacteria: 2 8.5 8.1 Example MIC (%) Fungi: 2 1-1 Whole plant 0.88 MIC (%) Bacteria: 0.5 21.9 15.1 MIC (%) Fungi: 0.5 1-2 Roots 0.96 MIC (%) Bacteria: 0.25 13.9 19.5 MIC (%) Fungi: 0.25 1-3 Stems 0.77 MIC (%) Bacteria: 0.5 24.1 16.1 MIC (%) Fungi: 0.5 1-4 Leaves 0.64 MIC (%) Bacteria: 0.5 27.8 17.9 MIC (%) Fungi: 0.5 1-5 Fruits 0.13 MIC (%) Bacteria: 0.125 22.8 19.0 MIC (%) Fungi: 0.125 1-6 Flowers 0.97 MIC (%) Bacteria: 0.0625 11.1 8.4 MIC (%) Fungi: 0.0625

EXAMPLE 2

Deodeok

[0105]

TABLE-US-00004 TABLE 4 Whitening Anti-wrinkle Anti-inflammation Moisturizing Conc. English Melanin Collagen synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name name content (%) (% of control) production (%) (%) Control Arbutin (200 ppm) TGFb (10 ppb) L-NMMA (5 ppm) EGF (10 ppb) group 35% 25% 28% 320% 2 Deodeok Codonopsis Deodeok lanceolata Comparative Pilose 50 Codonopsis 98.81 2.34 2.64 10.34 Example asiabell Pilosula 2-1 Whole 2 36.56 15.55 25.86 376.57 plant 10 33.66 25.01 32.54 498.43 50 25.39 39.40 34.86 654.56 2-2 Roots 2 47.81 11.58 10.16 10.77 10 41.70 14.34 13.68 59.86 50 31.62 15.96 14.78 66.59 2-3 Stems 2 37.26 14.59 25.93 380.41 10 32.92 29.14 29.48 483.35 50 23.76 35.25 34.03 629.94 2-4 Leaves 2 35.40 19.24 26.68 298.83 10 27.43 29.68 27.53 557.21 50 22.63 35.74 35.11 763.79 2-5 Fruits 2 39.94 12.90 21.47 213.22 10 29.09 28.83 32.19 512.23 50 24.11 35.27 35.73 763.76 2-6 Flowers 2 34.37 13.44 20.36 287.30 10 27.81 20.40 31.74 557.13 50 20.01 30.11 38.08 642.15

TABLE-US-00005 TABLE 5 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth English Anti-oxidation Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name name IC50 (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 2 Deodeok Codonopsis lanceolata Deodeok Comparative Pilose Codonopsis Pilosula 6.78 MIC (%) Bacteria: 2 11.1 13.2 Example asiabell MIC (%) Fungi: 2 2-1 Whole 0.84 MIC (%) Bacteria: 0.25 16.2 17.7 plant MIC (%) Fungi: 0.25 2-2 Roots 1.34 MIC (%) Bacteria: 1 23.3 25.8 MIC (%) Fungi: 1 2-3 Stems 0.74 MIC (%) Bacteria: 0.0625 13.4 22.3 MIC (%) Fungi: 0.0625 2-4 Leaves 0.47 MIC (%) Bacteria: 0.5 10.6 13.4 MIC (%) Fungi: 0.5 2-5 Fruits 0.99 MIC (%) Bacteria: 0.5 14.3 8.8 MIC (%) Fungi: 0.5 2-6 Flowers 0.85 MIC (%) Bacteria: 0.5 21.6 21.1 MIC (%) Fungi: 0.5

EXAMPLE 3

Ulleung Goldenrod

[0106]

TABLE-US-00006 TABLE 6 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition of Moisturizing Conc. English Melanin synthesis NO production HA synthesis No. Sample (ppm) Scientific name name content (%) (% of control) (%) (%) Control Arbutin (200 ppm) TGFb (10 ppb) L-NMMA (5 ppm) EGF (10 ppb) group 35% 25% 28% 320% 3 Ulleung Solidago Ulleung goldenrod virgaurea subsp. goldenrod Gigantea Comparative Canadian 50 Solidago 61.25 10.02 2.68 52.64 Example1 goldenrod Canadensis Comparative European 50 Solidago 45.27 8.11 10.77 150.44 Example2 goldenrod virgaurea var. (Whole plant) leiocarpa 3-1 Whole 2 34.61 10.91 20.78 207.09 plant 10 32.89 20.92 30.81 595.19 50 23.81 37.93 36.47 722.54 3-2 Roots 2 37.54 18.92 25.58 276.27 10 28.83 28.31 29.70 503.07 50 22.82 33.63 34.58 645.75 3-3 Stems 2 34.86 11.15 26.42 275.04 10 33.33 26.25 30.85 425.87 50 25.32 37.04 36.02 697.23 3-4 Leaves 2 39.29 11.33 23.72 394.14 10 27.03 24.44 28.91 544.89 50 21.20 34.94 38.52 797.78 3-5 Fruits 2 37.20 11.05 25.04 200.97 10 32.63 24.53 28.92 580.65 50 20.88 35.86 35.27 665.67 3-6 Flowers 2 39.98 11.13 23.18 334.25 10 29.18 24.37 33.37 481.45 50 24.68 36.84 38.81 777.36

TABLE-US-00007 TABLE 7 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Anti- Size of growth Size of growth Conc. English oxidation Anti-bacteria inhibition ring inhibition ring No. Sample (ppm) Scientific name name IC50 (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 3 Ulleung Solidago virgaurea Ulleung goldenrod subsp. Gigantea goldenrod Comparative Canadian 50 Solidago Canadensis 2.45 MIC (%) Bacteria: 1 15.1 11.8 Example1 goldenrod MIC (%) Fungi: 1 Comparative European 50 Solidago virgaurea 2.11 MIC (%) Bacteria: 1 11.8 8.7 Example2 goldenrod var. leiocarpa (Whole plant) MIC (%) Fungi: 1 3-1 Whole 2 0.48 MIC (%) Bacteria: 0.5 22.5 19.0 plant 10 MIC (%) Fungi: 0.25 50 3-2 Roots 2 0.58 MIC (%) Bacteria: 0.5 25.0 19.4 10 MIC (%) Fungi: 0.25 50 3-3 Stems 2 0.88 MIC (%) Bacteria: 0.5 10.3 9.4 10 MIC (%) Fungi: 0.25 50 3-4 Leaves 2 0.96 MIC (%) Bacteria: 0.25 15.7 16.7 10 MIC (%) Fungi: 0.25 50 3-5 Fruits 2 0.85 MIC (%) Bacteria: 0.5 9.3 10.4 10 MIC (%) Fungi: 0.25 50 3-6 Flowers 2 0.87 MIC (%) Bacteria: 0.25 24.7 24.6 10 MIC (%) Fungi: 0.125 50

EXAMPLE 5

Ulleungdo Aster

[0107]

TABLE-US-00008 TABLE 8 Whitening Anti-wrinkle Anti-inflammation Moisturizing Conc. English Melanin Collagen synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name name content (%) (% of control) production (%) (%) Control Arbutin (200 ppm) TGFb (10 ppb) L-NMMA (5 ppm) EGF (10 ppb) group 35% 25% 28% 320% 5 Ulleungdo Aster glehnii Ulleungdo aster aster Comparative Ulleungdo 50 Aster glehnii 62.23 10.42 15.02 100.64 Example aster (other area) Comparative Aster 50 Aster Yomena 80.76 4.98 5.25 34.82 Example 5-1 Whole 2 37.51 17.34 25.80 205.45 plant 10 33.86 20.38 32.44 491.79 50 24.66 33.77 35.69 707.09 5-2 Roots 2 34.29 11.39 25.14 259.24 10 28.36 20.40 33.28 593.29 50 21.69 38.01 34.59 789.90 5-3 Stems 2 37.98 15.13 26.97 270.31 10 30.32 28.50 27.89 595.08 50 26.82 38.84 37.02 641.95 5-4 Leaves 2 35.03 11.77 25.97 284.00 10 32.94 23.15 30.73 590.13 50 26.26 34.57 34.14 635.28 5-5 Fruits 2 36.86 10.66 24.47 367.08 10 28.05 29.31 31.71 445.51 50 20.93 37.37 39.03 706.53 5-6 Flowers 2 39.75 18.42 25.85 345.91 10 30.29 27.07 27.96 437.49 50 20.43 39.22 36.45 724.41 5-7 Shoots 2 38.47 12.97 25.43 210.57 10 33.77 24.93 33.53 424.05 50 22.20 31.37 36.67 696.15

TABLE-US-00009 TABLE 9 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Anti- Size of growth Size of growth English oxidation Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name name IC50 (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 5 Ulleungdo Aster glehnii Ulleungdo aster aster Comparative Ulleungdo Aster glehnii 2.52 MIC (%) Bacteria: 1 16.7 16.0 Example aster (other area) MIC (%) Fungi: 1 Comparative Aster Aster Yomena 3.93 MIC (%) Bacteria: >2 13.1 19.0 Example MIC (%) Fungi: >2 5-1 Whole 0.12 MIC (%) Bacteria: 0.25 22.6 27.5 plant MIC (%) Fungi: 0.25 5-2 Roots 0.02 MIC (%) Bacteria: 0.5 27.8 20.1 MIC (%) Fungi: 0.25 5-3 Stems 0.50 MIC (%) Bacteria: 1 15.9 13.0 MIC (%) Fungi: 0.5 5-4 Leaves 0.52 MIC (%) Bacteria: 1 13.1 13.5 MIC (%) Fungi: 1 5-5 Fruits 0.54 MIC (%) Bacteria: 0.5 11.9 14.1 MIC (%) Fungi: 0.25 5-6 Flowers 0.69 MIC (%) Bacteria: 0.25 8.7 9.0 MIC (%) Fungi: 0.25 5-7 Shoots 0.78 MIC (%) Bacteria: 1 23.3 17.2 MIC (%) Fungi: 1

EXAMPLE 6

Myeongyi

[0108]

TABLE-US-00010 TABLE 10 Whitening Anti-wrinkle Anti-inflammation Moisturizing Conc. Scientific English Melanin Collagen synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 6 Myeongyi Allium victorialis Myeongyi Comparative Garlic 50 Allium Sativum 77.95 14.24  3.05  73.76 Example 6-1 Whole plant 2 38.45 10.95 20.51 388.28 10 28.60 20.61 27.05 582.69 50 23.93 34.76 38.02 623.48 6-2 Roots 2 35.97 17.15 26.52 400.58 10 33.95 21.18 33.24 507.00 50 26.51 31.11 37.38 660.75 6-3 Stems 2 39.12 10.26 26.27 209.64 10 28.79 28.91 31.09 559.99 50 25.94 33.37 35.71 702.71 6-4 Leaves 2 36.64 17.53 23.66 219.80 10 33.92 25.20 31.66 543.26 50 25.64 30.77 35.10 626.32 6-5 Fruits 2 39.58 18.69 25.04 255.24 10 30.50 20.97 30.88 595.46 50 23.75 36.64 35.69 659.26 6-6 Flowers 2 34.07 13.61 22.05 296.84 10 30.33 27.69 31.21 419.24 50 26.90 36.98 37.68 689.02

TABLE-US-00011 TABLE 11 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 6 Myeongyi Allium victorialis Myeongyi Comparative Garlic Allium Sativum 3.52 MIC (%) Bacteria: 2 11.1 12.9 Example MIC (%) Fungi: 1 6-1 Whole plant 0.73 MIC (%) Bacteria: 0.25 14.9 19.4 MIC (%) Fungi: 0.5 6-2 Roots 0.27 MIC (%) Bacteria: 1 12.8 13.5 MIC (%) Fungi: 1 6-3 Stems 0.18 MIC (%) Bacteria: 1 10.0 14.4 MIC (%) Fungi: 0.5 6-4 Leaves 0.36 MIC (%) Bacteria: 0.125 16.8 14.4 MIC (%) Fungi: 0.25 6-5 Fruits 0.27 MIC (%) Bacteria: 0.5 21.3 24.1 MIC (%) Fungi: 0.5 6-6 Flowers 0.44 MIC (%) Bacteria: 0.125 12.5 16.6 MIC (%) Fungi: 0.25

EXAMPLE 7

Aging Chive

[0109]

TABLE-US-00012 TABLE 12 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizng Conc. Scientific English Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 7 Aging chive Allium senescens Aging chive Comparative Chive 50 Allium Tuberosum 52.06 15.42  7.68  79.87 Example 7-1 Whole plant 2 38.07 16.08 24.27 379.52 10 28.44 27.62 27.63 501.87 50 23.58 30.75 34.13 642.80 7-2 Roots 2 34.62 15.86 21.97 226.89 10 30.32 21.09 30.44 424.33 50 26.68 32.52 36.80 703.68 7-4 Leaves 2 35.78 11.69 31.38 181.63 10 28.40 15.26 41.36 274.64 50 25.55 19.15 56.99 487.67 7-5 Fruits 2 37.02 16.53 22.76 236.69 10 27.93 28.95 32.32 473.43 50 22.03 33.68 38.05 723.11 7-6 Flowers 2 27.84 13.05 21.47 300.18 10 18.26 20.55 31.58 514.97 50 12.01 36.51 39.51 800.56

TABLE-US-00013 TABLE 13 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 7 Aging chive Allium senescens Aging chive Comparative Chive Allium Tuberosum 2.74 MIC (%) Bacteria: 1 9.6 8.9 Example MIC (%) Fungi: 2 7-1 Whole plant 0.20 MIC (%) Bacteria: 1 19.6 22.6 MIC (%) Fungi: 0.5 7-2 Roots 0.37 MIC (%) Bacteria: 1 9.1 8.9 MIC (%) Fungi: 1 7-4 Leaves 0.51 MIC (%) Bacteria: 0.5 22.1 22.6 MIC (%) Fungi: 0.5 7-5 Fruits 0.34 MIC (%) Bacteria: 0,5 10.6 8.8 MIC (%) Fungi: 0.25 7-6 Flowers 0.07 MIC (%) Bacteria: 0.13 14.9 19.7 MIC (%) Fungi: 0.06

EXAMPLE 8

Silvery Mountain Ash

[0110]

TABLE-US-00014 TABLE 14 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Scientific English Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 8 Silvery mountain Sorbus commixta Silvery mountain ash ash Comparative Wild pear tree 50 Sorbus alnifolia 61.11  9.55  4.08  95.25 Example Comparative Silvery mountain 50 Sorbus commixta 49.03 16.63 10.63 268.61 Example ash (other area) 8-1 Whole plant 2 36.68 10.84 25.91 274.89 10 27.35 26.63 27.92 438.35 50 25.28 33.84 38.79 643.28 8-2 Roots 2 37.44 17.33 24.72 269.07 10 28.07 22.13 30.59 441.39 50 20.83 31.53 37.60 733.14 8-3 Bark 2 38.20 13.91 22.84 253.50 10 31.60 27.09 32.36 494.36 50 21.43 34.05 37.10 671.99 8-4 Leaves 2 39.72 10.26 24.92 400.91 10 29.63 22.21 33.55 424.09 50 25.41 34.91 36.93 691.17 8-5 Fruits 2 37.10 14.75 26.59 256.05 10 32.15 23.88 27.51 527.60 50 23.86 32.74 37.12 686.07 8-6 Flowers 2 39.86 13.29 25.14 235.83 10 28.03 29.53 28.17 427.91 50 20.48 34.30 37.28 796.52 8-7 Branches 2 38.43 15.83 25.15 244.29 10 28.89 28.37 30.50 578.10 50 23.06 35.87 37.94 764.41

TABLE-US-00015 TABLE 15 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 8 Silvery mountain Sorbus commixta Silvery ash mountain ash Comparative Wild pear tree Sorbus alnifolia 3.87 MIC (%) Bacteria: >2 0.0 0.0 Example MIC (%) Fungi: >2 Comparative Silvery mountain Sorbus commixta 1.06 MIC (%) Bacteria: 0.5 10.6 8.8 Example ash (other area) MIC (%) Fungi: 1 8-1 Whole plant 0.11 MIC (%) Bacteria: 0.5 21.8 18.7 MIC (%) Fungi: 0.25 8-2 Roots 0.14 MIC (%) Bacteria: 0.25 9.0 11.2 MIC (%) Fungi: 0.13 8-3 Bark 0.30 MIC (%) Bacteria: 0.13 21.8 21.3 MIC (%) Fungi: 0.25 8-4 Leaves 0.73 MIC (%) Bacteria: 0.25 24.4 16.5 MIC (%) Fungi: 0.13 8-5 Fruits 0.70 MIC (%) Bacteria: 0.5 26.3 27.0 MIC (%) Fungi: 1 8-6 Flowers 0.86 MIC (%) Bacteria: 0.13 17.1 20.8 MIC (%) Fungi: 0.06 8-7 Branches 0.29 MIC (%) Bacteria: 0.5 25.2 21.1 MIC (%) Fungi: 0.25

EXAMPLE 10

Wild Chervil

[0111]

TABLE-US-00016 TABLE 16 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Scientific English Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 10 Wild chervil Anthriscus sylvestris Wild chervil Comparative Chervil 50 Anthriscus Cerefolium 65.80  5.45  6.44  45.59 Example 10-1 Whole plant 2 37.81 17.65 23.37 394.44 10 27.02 21.45 27.51 553.58 50 23.67 34.67 35.97 632.62 10-2 Roots 2 31.87 11.64 22.77 241.74 10 27.06 22.16 33.74 402.96 50 21.94 39.19 35.10 644.03 10-3 Stems 2 34.76 18.48 26.38 399.00 10 30.08 28.90 28.71 600.83 50 22.10 38.32 37.78 613.72 10-4 Leaves 2 37.30 11.84 25.46 380.25 10 28.82 29.39 28.65 523.39 50 28.89 37.22 34.90 723.91 10-5 Fruits 2 34.52 12.18 23.94 360.97 10 29.50 28.36 30.47 409.65 50 23.11 31.53 39.49 718.16 10-6 Flowers 2 39.02 12.16 25.41 334.85 10 28.90 26.24 31.70 415.00 50 26.56 35.25 38.01 725.14

TABLE-US-00017 TABLE 17 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 10 Wild chervil Anthriscus Wild chervil sylvestris Comparative Chervil Anthriscus 3.96 MIC (%) Bacteria: 2, Fungi: 2 9.5 8.1 Example Cerefolium 10-1 Whole plant 0.46 MIC (%) Bacteria: 1, Fungi: 0.25 20.4 18.9 10-2 Roots 0.88 MIC (%) Bacteria: 2, Fungi: 1 13.5 14.6 10-3 Stems 0.77 MIC (%) Bacteria: 1, Fungi: 0.5 27.9 25.6 10-4 Leaves 0.14 MIC (%) Bacteria; 0.5, Fungi: 0.125 26.4 22.8 10-5 Fruits 0.21 MIC (%) Bacteria: 1, Fungi: 0.5 8.1 13.5 10-6 Flowers 0.14 MIC (%) Bacteria: 1, Fungi: 0.5 11.7 14.6

EXAMPLE 11

Giant Knotweed

[0112]

TABLE-US-00018 TABLE 18 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Scientific English Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 11 Giant Knotweed Fallopia sachalinensis Giant Knotweed 11-1 Whole plant 2 59.68 11.66 21.01 387.34 10 31.07 21.49 28.05 428.82 50 24.89 37.23 36.38 650.06 11-2 Roots 2 37.83 10.41 15.84 214.49 10 29.15 21.60 26.64 530.09 50 26.87 32.10 28.28 639.00 11-3 Stems 2 36.28 17.19 22.76 279.70 10 27.78 22.50 29.33 505.63 50 24.85 34.45 38.58 678.94 11-4 Leaves 2 34.94 18.84 17.72 341.25 10 30.33 20.37 27.18 576.23 50 25.03 32.53 30.71 668.77 11-5 Fruits 2 36.97 18.82 15.32 254.31 10 29.51 21.90 26.35 484.44 50 25.87 33.63 30.42 800.32 11-6 Flowers 2 36.34 13.90 23.72 315.29 10 30.06 29.19 32.24 488.00 50 20.16 35.56 36.27 712.56

TABLE-US-00019 TABLE 19 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 11 Giant Knotweed Fallopia Giant sachalinensis Knotweed 11-1 Whole plant 0.46 MIC (%) Bacteria: 1, Fungi: 0.25 14.4 12.2 11-2 Roots 0.98 MIC (%) Bacteria: 2, Fungi: 1 9.8 9.2 11-3 Stems 0.70 MIC (%) Bacteria: 1, Fungi: 0.5 12.3 11.3 11-4 Leaves 0.10 MIC (%) Bacteria: 0.5, Fungi: 0.25 23.0 25.3 11-5 Fruits 0.74 MIC (%) Bacteria: 0.5, Fungi: 0.5 11.3 8.8 11-6 Flowers 0.53 MIC (%) Bacteria: 0.5, Fungi: 0.5 12.8 15.0

EXAMPLE 12

Mono Maple

[0113]

TABLE-US-00020 TABLE 20 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Scientific English Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 12 Mono maple Acer pictum Mono maple Comparative Maple 50 Acer Saccharum Sugar Maple 70.79  9.64  3.41  75.42 Example 12-1 Whole plant 2 35.24 13.80 26.11 243.88 10 27.75 21.80 33.43 550.99 50 25.33 31.77 37.13 643.20 12-2 Roots 2 35.39 17.80 26.93 215.59 10 29.91 29.57 31.84 423.71 50 23.03 35.14 39.54 755.21 12-3 Stems 2 38.18 19.84 25.31 367.01 10 30.15 22.37 33.55 485.49 50 26.78 34.90 37.67 620.17 12-4 Leaves 2 36.31 14.39 21.89 327.34 10 33.74 22.68 30.11 458.76 50 24.72 32.20 37.51 642.40 12-5 Fruits 2 38.27 14.80 24.19 279.00 10 28.81 22.96 32.62 557.16 50 22.25 38.03 38.01 671.92 12-6 Flowers 2 37.68 13.94 26.62 226.58 10 28.40 20.88 33.40 434.92 50 21.51 38.30 38.72 722.56 12-7 Sap 2 38.21 10.94 25.49 395.96 10 30.70 27.21 32.47 540.47 50 26.28 34.24 37.18 662.98

TABLE-US-00021 TABLE 21 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 12 Mono maple Acer pictum Mono maple Comparative Maple Acer Saccharum Sugar Maple 1.89 MIC (%) Bacteria: >2 10.3 8.9 Example MIC (%) Fungi: 2 12-1 Whole plant 0.53 MIC (%) Bacteria: 0,5 24.6 23.7 MIC (%) Fungi: 0.125 12-2 Roots 0.08 MIC (%) Bacteria: 0.25 24.1 27.4 MIC (%) Fungi: 0.125 12-3 Stems 0.63 MIC (%) Bacteria: 0.5 27.4 12.1 MIC (%) Fungi: 0.5 12-4 Leaves 0.34 MIC (%) Bacteria: 1 23.1 27.0 MIC (%) Fungi: 0.25 12-5 Fruits 0.19 MIC (%) Bacteria: 0.5 12.9 11.1 MIC (%) Fungi: 0.25 12-6 Flowers 0.31 MIC (%) Bacteria: 0.25 23.1 12.3 MIC (%) Fungi: 0.125 12-7 Sap 0.40 MIC (%) Bacteria: 0.5 24.4 26.5 MIC (%) Fungi: 0.5

EXAMPLE 13

Ulleungdo Ladyfern

[0114]

TABLE-US-00022 TABLE 22 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Scientific English Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 13 Ulleungdo Athyrium Ulleungdo ladyfern acutipinnulum ladyfern 13-1 Whole plant 2 35.20 10.14 23.14 361.62 10 28.32 23.20 29.45 563.53 50 26.99 31.14 34.98 639.02 13-2 Roots 2 38.10 16.81 25.76 366.29 10 30.22 20.33 28.06 526.26 50 20.81 35.25 35.77 698.90 13-3 Stems 2 38.42 18.18 23.02 242.99 10 33.26 26.68 30.38 512.00 50 21.47 34.54 39.37 726.00 13-4 Leaves 2 37.84 18.20 26.33 265.80 10 33.65 26.72 33.73 507.92 50 21.22 38.69 37.98 702.42

TABLE-US-00023 TABLE 23 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeiuginosa 2% 0 mm 0 mm Fungi: A. niger 1% 13 Ulleungdo Athyrium Ulleungdo ladyfern acutipinnulum ladyfern 13-1 Whole plant 0.92 MIC (%) Bacteria: 0.5 18.4 18.8 MIC (%) Fungi: 0.5 13-2 Roots 0.82 MIC (%) Bacteria: 0.25 13.2 15.7 MIC (%) Fungi: 0.25 13-3 Stems 0.85 MIC (%) Bacteria: 0.125 13.2 14.7 MIC (%) Fungi: 0.5 13-4 Leaves 0.13 MIC (%) Bacteria: 0.125 12.7 14.6 MIC (%) Fungi: 0.25

EXAMPLE 14

Wild Wasabi

[0115]

TABLE-US-00024 TABLE 24 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Scientific English Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 14 Wild wasabi Wasabia japonica Wild wasabi 14-1 Whole plant 2 35.18 12.15 26.01 354.70 10 32.28 25.75 29.52 572.56 50 23.12 32.46 38.97 691.59 14-2 Roots 2 34.08 17.46 22.04 328.75 10 32.61 25.85 31.88 428.89 50 20.82 37.85 35.63 789.50 14-3 Stems 2 39.68 19.43 22.97 314.61 10 33.77 28.64 31.00 487.16 50 26.86 34.38 35.05 636.91 14-4 Leaves 2 34.12 18.73 24.89 265.98 10 30.48 29.53 32.04 575.39 50 26.31 31.22 34.50 759.63 14-5 Fruits 2 34.30 14.83 25.50 230.84 10 33.86 22.03 32.66 449.33 50 22.44 37.72 37.47 768.96 14-6 Flowers 2 37.74 14.83 24.21 266.20 10 27.39 22.03 31.29 499.43 50 21.64 37.72 37.27 765.75

TABLE-US-00025 TABLE 25 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 14 Wild Wasabia Wild wasabi japonica wasabi 14-1 Whole plant 0.89 MIC (%) Bacteria: 0.25 18.8 8.1 MIC (%) Fungi: 0.125 14-2 Roots 0.27 MIC (%) Bacteria: 0.0625 12.8 14.0 MIC (%) Fungi: 0.0625 14-3 Stems 0.51 MIC (%) Bacteria: 0.25 25.1 13.4 MIC (%) Fungi: 0.125 14-4 Leaves 0.96 MIC (%) Bacteria: 0.25 27.9 21.3 MIC (%) Fungi: 0.125 14-5 Fruits 0.02 MIC (%) Bacteria: 0.125 15.5 8.1 MIC (%) Fungi: 0.125 14-6 Flowers 0.29 MIC (%) Bacteria: 0.125 16.0 12.0 MIC (%) Fungi: 0.25

EXAMPLE 15

Yellow Mongolian Snakegourd

[0116]

TABLE-US-00026 TABLE 26 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 15 Yellow Trichosanthes Yellow Mongolian kirilowii Mongolian snakegourd snakegourd Compar- Snake 50 Trichosanthes Shake 66.95 4.44  2.14  53.86 ative gourd Cucumerina gourd Example Compar- Yellow 50 45.93 9.03 13.82 194.00 ative Mongolian Example snakegourd (other area) 15-1 Whole plant 2 35.80 17.08 22.73 267.84 10 30.80 21.87 29.58 511.44 50 23.06 35.88 37.35 638.89 15-2 Roots 2 36.13 11.89 26.42 360.15 10 31.31 26.10 29.76 408.58 50 25.67 33.81 37.26 607.40 15-3 Stems 2 35.44 10.74 22.17 275.00 10 32.51 20.34 27.22 452.01 50 20.11 36.15 36.19 643.27 15-4 Leaves 2 37.49 14.50 26.48 373.49 10 27.21 28.93 33.56 576.12 50 25.29 37.16 38.71 696.96 15-5 Fruits 2 34.58 19.98 21.13 245.22 10 33.69 29.38 31.64 547.50 50 22.01 39.65 36.13 741.23 15-6 Flowers 2 39.06 15.76 23.17 212.73 10 32.26 28.48 29.66 508.65 50 23.44 37.03 37.41 622.40

TABLE-US-00027 TABLE 27 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 15 Yellow Trichosanthes Yellow Mongolian kirilowii Mongolian snakegourd snakegourd Compar- Snake Trichosanthes Shake 3.24 MIC (%) Bacteria: 0.5,  8.9 9.6 ative gourd Cucumerina gourd Fungi: 1 Example Compar- Yellow 2.94 MIC (%) Bacteria: 2, 12.1 11.8 ative Mongolian Fungi: 1 Example snakegourd (other area) 15-1 Whole plant 0.82 MIC (%) Bacteria: 0.25, 19.0 18.9 Fungi: 0.125 15-2 Roots 0.32 MIC (%) Bacteria: 1, 12.1 13.1 Fungi: 0.125 15-3 Stems 0.51 MIC (%) Bacteria: 1, 21.5 10.8 Fungi: 0.5 15-4 Leaves 0.89 MIC (%) Bacteria: 1, 12.9 20.0 Fungi: 1 15-5 Fruits 0.23 MIC (%) Bacteria: 2, 16.4 9.2 Fungi: 0.5 15-6 Flowers 0.48 MIC (%) Bacteria: 1, 24.3 24.5 Fungi: 0.25

EXAMPLE 16

Pungdo Solomon's Seal

[0117]

TABLE-US-00028 TABLE 28 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 16 Pungdo Polygonatum Pungdo solomon's odoratum solomon's seal seal Compar- Solomon's 50 Polygonatum 67.65 15.62  2.18  38.60 ative seal Officinale Example 16-1 Whole plant 2 37.85 16.85 20.23 322.89 10 28.02 25.19 28.22 583.88 50 24.42 38.61 37.58 700.87 16-2 Roots 2 38.18 15.81 20.55 264.71 10 33.87 15.14 24.42 326.80 50 31.39 27.59 27.62 493.86 16-3 Stems 2 35.94 18.27 23.63 211.64 10 31.14 25.63 30.87 555.83 50 20.29 33.29 37.47 792.53 16-4 Leaves 2 35.15 15.01 20.87 391.90 10 28.15 20.87 32.69 446.94 50 21.57 31.25 36.47 606.81 16-5 Fruits 2 36.65 10.37 26.18 237.45 10 29.90 28.16 30.74 537.46 50 20.10 35.81 36.98 609.72 16-6 Flowers 2 38.80 12.43 20.13 235.88 10 36.17 18.65 26.23 384.95 50 28.88 29.62 30.19 432.12

TABLE-US-00029 TABLE 29 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 16 Pungdo Polygonatum Pungdo solomon's odoratum solomon's seal seal Compar- Solomon's Polygonatum 2.55 MIC (%) Bacteria: 2, 9.5 9.5 ative seal Officinale Fungi: >2 Example 16-1 Whole plant 0.05 MIC (%) Bacteria: 0.5, 19.6 21.6 Fungi: 0.25 16-2 Roots 0.62 MIC (%) Bacteria: 2, 9.8 10.2 Fungi: 0.5 16-3 Stems 0.08 MIC (%) Bacteria: 1, 17.0 14.6 Fungi: 0.25 16-4 Leaves 0.68 MIC (%) Bacteria: 0.25, 19.3 25.7 Fungi: 0.5 16-5 Fruits 0.88 MIC (%) Bacteria: 2, 9.2 9.8 Fungi: 0.25 16-6 Flowers 1.15 MIC (%) Bacteria: 0.5, 12.3 11.5 Fungi: 0.25

EXAMPLE 17

Songak

[0118]

TABLE-US-00030 TABLE 30 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 17 Songak Hedera Songak rhombea Compar- Ivy 50 Hedera IVY 75.07 12.30  5.61  69.05 ative Helix Example 17-1 Whole plant 2 39.70 13.18 25.95 384.76 10 34.03 16.74 33.68 533.11 50 30.20 26.66 35.29 630.99 17-2 Roots 2 34.73 14.66 26.78 363.91 10 27.47 26.35 33.73 557.23 50 22.11 39.47 38.77 747.46 17-3 Stems 2 35.28 19.96 23.79 292.85 10 33.57 21.59 26.44 451.96 50 21.01 36.37 27.76 675.93 17-4 Leaves 2 37.81 10.90 20.04 327.85 10 27.26 23.01 24.58 453.75 50 21.00 34.21 28.03 652.23 17-5 Fruits 2 34.71 18.38 25.58 340.23 10 33.71 27.23 32.03 432.18 50 20.61 36.10 36.33 755.89 17-6 Flowers 2 39.56 10.48 25.40 295.11 10 32.14 27.90 31.89 547.33 50 22.92 37.56 36.88 756.04

TABLE-US-00031 TABLE 31 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 17 Songak Hedera Songak rhombea Compar- Ivy Hedera IVY 3.14 MIC (%) Bacteria: >2, 0.0 0.0 ative Helix Fungi: >2 Example 17-1 Whole plant 1.25 MIC (%) Bacteria: 1, 9.7 8.6 Fungi: 0.25 17-2 Roots 0.53 MIC (%) Bacteria: 0.25, 8.7 8.7 Fungi: 0.5 17-3 Stems 1.42 MIC (%) Bacteria: 1, 7.2 10.6 Fungi: 0.25 17-4 Leaves 1.06 MIC (%) Bacteria: 0.25, 12.2  12.7 Fungi: 0.5 17-5 Fruits 0.22 MIC (%) Bacteria: 1, 9.3 11.0 Fungi: 1 17-6 Flowers 0.95 MIC (%) Bacteria: 0.0625, 8.2 9.9 Fungi:

EXAMPLE 18

Ulleungdo Sweet Violet

[0119]

TABLE-US-00032 TABLE 32 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 18 Ulleungdo Viola Ulleungdo sweet woosanensis sweet violet violet Compar- Violet 50 Viola 69.26  8.30  3.84  50.72 ative Mandshurica Example 18-1 Whole plant 2 34.87 10.56 26.39 212.88 10 33.86 24.79 28.63 508.12 50 24.44 34.91 38.68 749.46 18-2 Roots 2 37.62 18.59 24.06 323.53 10 31.95 20.58 27.71 568.50 50 24.77 38.02 38.25 721.49 18-3 Stems 2 35.35 18.71 26.57 390.60 10 30.90 29.76 32.70 547.48 50 22.54 31.26 38.74 742.86 18-4 Leaves 2 38.50 17.40 21.87 357.39 10 29.13 29.08 29.15 416.77 50 21.22 35.01 39.57 707.45 18-5 Fruits 2 39.87 10.46 23.24 365.58 10 28.73 26.11 29.69 505.28 50 22.21 38.83 34.40 611.69 18-6 Flowers 2 35.79 19.49 22.75 248.41 10 29.87 25.59 27.75 403.78 50 22.64 35.81 37.27 756.55

TABLE-US-00033 TABLE 33 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 18 Ulleungdo Viola Ulleungdo sweet woosanensis sweet violet violet Compar- Violet Viola 5.56 MIC (%) Bacteria: 2, 11.5  9.3 ative Mandshurica Fungi: 2 Example 18-1 Whole plant 0.35 MIC (%) Bacteria: 1, 21.5 17.5 Fungi: 0.25 18-2 Roots 0.25 MIC (%) Bacteria: 1, 13.9 13.6 Fungi: 1 18-3 Stems 0.71 MIC (%) Bacteria: 0.5, 21.5 14.9 Fungi: 0.5 18-4 Leaves 0.37 MIC (%) Bacteria: 0.5, 13.6 24.0 Fungi: 0.25 18-5 Fruits 0.82 MIC (%) Bacteria: 0.5, 18.2 14.1 Fungi: 0.5 18-6 Flowers 0.55 MIC (%) Bacteria: 1, 17.3 11.6 Fungi: 0.5

EXAMPLE 19

Korean Bellflower

[0120]

TABLE-US-00034 TABLE 34 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 19 Korean Campanula Korean bellflower takesimana bellflower Compar- Bellflower 50 Campanula 57.17 10.93  2.02  81.77 ative punctata Example 19-1 Whole plant 2 36.28 14.05 24.36 372.27 10 29.14 27.50 32.48 566.92 50 20.91 33.70 37.44 671.09 19-2 Roots 2 38.31 18.87 24.89 298.71 10 28.06 26.72 29.80 413.73 50 24.92 38.86 39.07 715.15 19-3 Stems 2 39.06 14.19 25.57 373.82 10 28.25 23.81 33.04 403.43 50 23.95 31.38 36.25 758.71 19-4 Leaves 2 36.07 12.77 22.81 305.58 10 29.29 27.83 29.52 470.42 50 23.15 35.33 34.43 763.66 19-5 Fruits 2 35.03 12.93 21.38 326.18 10 32.89 24.26 32.29 506.96 50 24.04 32.28 34.07 625.68 19-6 Flowers 2 35.53 16.85 21.71 257.53 10 32.44 21.94 29.23 533.07 50 23.25 38.09 37.03 752.50

TABLE-US-00035 TABLE 35 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 19 Korean Campanula Korean bellflower takesimana bellflower Compar- Bellflower Campanula 9.87 MIC (%) Bacteria: >2/ 10.9 11.3 ative punctata Fungi: 2 Example 19-1 Whole plant 0.21 MIC (%) Bacteria: 2/ 26.2 16.3 Fungi: 1 19-2 Roots 0.43 MIC (%) Bacteria: 0.5, 9.2 20.7 Fungi: 0.5 19-3 Stems 0.17 MIC (%) Bacteria: 1, 15.1 12.8 Fungi: 0.5 19-4 Leaves 0.1  MIC (%) Bacteria: 1, 19.9 22.2 Fungi: 0.5 19-5 Fruits 0.42 MIC (%) Bacteria: 1, 9.9 22.0 Fungi: 1 19-6 Flowers 0.94 MIC (%) Bacteria: 0.25, 26.9 26.0 Fungi: 0.25

EXAMPLE 20

Ulleungdo Turk's-Cap Lily

[0121]

TABLE-US-00036 TABLE 36 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 20 Ulleungdo Lilium Ulleungdo turk's- hansonii turk's- cap lily cap lily Compar- Lily 50 Lilium 86.37 12.59  3.10  46.18 ative Candidum Example 20-1 Whole plant 2 39.78 14.51 20.75 307.30 10 30.75 27.01 33.36 445.02 50 24.62 35.30 38.39 686.19 20-2 Roots 2 34.17 14.40 21.72 263.94 10 30.82 23.13 29.24 435.95 50 22.66 37.10 38.03 715.89 20-3 Stems 2 36.90 18.14 21.35 304.03 10 33.77 23.81 27.20 461.21 50 23.27 39.45 34.39 708.43 20-4 Leaves 2 36.53 14.41 23.56 226.56 10 32.88 24.26 30.21 597.01 50 24.22 37.57 34.91 771.58 20-5 Fruits 2 39.07 17.29 21.08 336.13 10 29.90 20.74 31.04 591.19 50 23.92 37.42 35.28 767.52 20-6 Flowers 2 34.70 18.76 25.64 356.83 10 33.45 22.78 28.46 449.21 50 24.08 36.69 38.14 735.30

TABLE-US-00037 TABLE 37 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 20 Ulleungdo Lilium Ulleungdo turk's- hansonii turk's- cap lily cap lily Compar- Lily Lilium 6.87 MIC (%) Bacteria: >2/ 12.3  9.4 ative Candidum Fungi: 2 Example 20-1 Whole plant 0.39 MIC (%) Bacteria: 0.5/ 18.4 21.5 Fungi: 0.5 20-2 Roots 0.37 MIC (%) Bacteria: 1, 12.7 25.5 Fungi: 0.25 20-3 Stems 0.91 MIC (%) Bacteria: 1, 13.8 20.3 Fungi: 0.5 20-4 Leaves 0.27 MIC (%) Bacteria: 1, 13.7 21.1 Fungi: 1 20-5 Fruits 0.88 MIC (%) Bacteria: 0.5, 10.9 12.0 Fungi: 0.5 20-6 Flowers 0.74 MIC (%) Bacteria: 0.25, 17.4 25.5 Fungi: 1

EXAMPLE 21

Ulleungdo Spike Speedwell

[0122]

TABLE-US-00038 TABLE 38 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Conc. Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample (ppm) name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 21 Ulleungdo Pseudolysimachion Ulleungdo spike insulare spike speedwell speedwell Compar- Speedwell 50 Veronica 3.17 MIC (%) Bacteria, 13.8 11.5 ative Officinalis Fungi: 2 Example 21-1 Whole plant 2 0.73 MIC (%) Bacteria: 1  8.3  9.0 10 MIC (%) Fungi: 0.5 17.8 19.7 50 21-2 Roots 2 0.9 MIC (%) Bacteria, 13.2 11.5 Fungi: 1 10 50 21-3 Stems 2 0.47 MIC (%) Bacteria, 23.4 13.7 Fungi: 1 10 50 21-4 Leaves 2 0.22 MIC (%) Bacteria: 0.25 23.6 22.0 10 MIC (%) Fungi: 0.5 50 21-5 Fruits 2 0.8 MIC (%) Bacteria: 0.25 10.3 11.8 10 MIC (%) Fungi: 0.25 50 21-6 Flowers 2 0.93 MIC (%) Bacteria: 0.25 14.2 15.1 10 MIC (%) Fungi: 1 50

TABLE-US-00039 TABLE 39 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) 21 Ulleungdo Pseudolysimachion Ulleungdo spike insulare spike speedwell speedwell Compar- Speedwell Veronica 3.17 MIC (%) Bacteria, 13.8 11.5 ative Officinalis Fungi: 2 Example 21-1 Whole plant 0.73 MIC (%) Bacteria: 1 8.3 9.0 MIC (%) Fungi: 0.5 17.8 19.7 21-2 Roots 0.9 MIC (%) Bacteria, 13.2 11.5 Fungi: 1 21-3 Stems 0.47 MIC (%) Bacteria, 23.4 13.7 Fungi: 1 21-4 Leaves 0.22 MIC (%) Bacteria: 0.25 23.6 22.0 MIC (%) Fungi: 0.5 21-5 Fruits 0.8 MIC (%) Bacteria: 0.25 10.3 11.8 MIC (%) Fungi: 0.25 21-6 Flowers 0.93 MIC (%) Bacteria: 0.25 14.2 15.1 MIC (%) Fungi: 1

EXAMPLE 22

Coastal Moss-Like Stonecrop

[0123]

TABLE-US-00040 TABLE 40 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 22 Coastal Sedum Coastal moss-like oryzifolium moss-like stonecrop stonecrop Compar- Orange 50 Sedum 80.19 6.04  3.98  13.00 ative stonecrop Kamtschaticum Example 22-1 Whole plant 2 45.74 3.60 11.19 298.50 10 38.34 17.52 19.66 598.40 50 35.36 26.37 26.84 785.92 22-2 Roots 2 37.34 13.83 20.45 312.88 10 33.85 28.34 29.29 403.47 50 22.45 37.74 39.25 735.40 22-3 Stems 2 34.48 15.30 26.40 315.03 10 31.12 24.10 29.97 495.51 50 25.25 38.15 34.96 719.30 22-4 Leaves 2 37.06 18.16 26.70 333.50 10 29.18 21.75 30.14 599.29 50 26.08 38.90 32.91 757.00 22-5 Fruits 2 38.07 18.34 21.39 248.33 10 33.40 29.93 30.26 560.51 50 23.70 34.97 31.63 708.07 22-6 Flowers 2 35.09 10.80 21.62 215.01 10 28.93 21.05 33.29 531.83 50 25.49 34.20 35.62 648.15

TABLE-US-00041 TABLE 41 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 22 Coastal Sedum Coastal moss-like oryzifolium moss-like stonecrop stonecrop Compar- Orange Sedum 9.25 MIC (%) Bacteria2, Fungi: 2  9.7 10.0 ative stonecrop Kamtschaticum Example 22-1 Whole plant 0.9  MIC (%) Bacteria, Fungi: 1 18.6 16.6 22-2 Roots 0.66 MIC (%) Bacteria, Fungi: 0.5 19.6 23.3 22-3 Stems 0.77 MIC (%) Bacteria, Fungi: 0.0625 15.3 20.1 22-4 Leaves 0.63 MIC (%) Bacteria: 0.125 26.7 14.9 MIC (%) Fungi: 0.25 22-5 Fruits 0.29 MIC (%) Bacteria: 0.25 17.2 12.0 MIC (%) Fungi: 0.5 22-6 Flowers 0.49 MIC (%) Bacteria: 0.25 16.0 16.1 MIC (%) Fungi: 0.125

EXAMPLE 23

Water Chickweed (Giant Chickweed)

[0124]

TABLE-US-00042 TABLE 42 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 23 Water Stellaria Water chickweed aquatica chickweed (Giant (Giant chickweed) chickweed) Compar- Chickweed 50 Stellaria 72.34  3.29  7.25  97.51 ative Media Example 23-1 Whole plant 2 39.14 15.12 24.37 261.94 10 28.86 25.28 30.96 455.93 50 24.18 32.21 34.75 659.55 23-2 Roots 2 35.91 17.10 22.57 218.92 10 29.12 29.98 28.85 450.38 50 20.51 43.46 39.79 733.82 23-3 Stems 2 36.96 13.61 24.24 261.55 10 32.40 21.65 33.21 593.68 50 25.25 31.46 37.75 674.45 23-4 Leaves 2 36.68 17.32 20.14 382.63 10 28.01 27.89 31.61 532.62 50 25.08 30.10 36.61 723.84 23-5 Fruits 2 39.55 10.55 26.03 371.93 10 28.84 27.40 31.11 553.71 50 20.67 33.06 37.01 726.98 23-6 Flowers 2 39.55 10.95 20.66 208.33 10 30.93 21.37 28.01 581.25 50 23.79 36.43 33.56 625.44

TABLE-US-00043 TABLE 43 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 23 Water Stellaria Water chickweed aquatica chickweed (Giant (Giant chickweed) chickweed) Compar- Chickweed Stellaria 8.7 MIC (%) Bacteria, Fungi: >2 12.5 10.9 ative Media Example 23-1 Whole plant 0.9 MIC (%) Bacteria, Fungi: 1 24.4 25.2 23-2 Roots 0.45 MIC (%) Bacteria, Fungi: 0.5 17.0 11.0 23-3 Stems 0.51 MIC (%) Bacteria, Fungi: 1 13.7 12.7 23-4 Leaves 0.71 MIC (%) Bacteria: 0.25 27.5 25.0 MIC (%) Fungi: 0.125 23-5 Fruits 0.86 MIC (%) Bacteria: 0.25 17.0 17.4 MIC (%) Fungi: 0.25 23-6 Flowers 0.39 MIC (%) Bacteria: 0.0625 27.3 26.9 MIC (%) Fungi: 0.125

EXAMPLE 24

Heartleaf Houttuynia

[0125]

TABLE-US-00044 TABLE 44 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 24 Heartleaf Houttuynia Heartleaf Houttuynia cordata Houttuynia Thunb. Compar- Heartleaf 50 89.15 17.24  1.12  45.73 ative Houttuynia Example (other area) 24-1 Whole plant 2 39.15 13.24 23.12 273.73 10 28.76 23.82 31.95 407.75 50 21.14 38.76 35.87 630.10 24-2 Roots 2 38.13 17.61 20.65 261.26 10 27.26 24.89 33.97 442.32 50 25.62 38.01 35.23 726.65 24-3 Stems 2 38.63 19.91 24.71 305.14 10 31.19 24.56 28.93 536.67 50 21.69 33.70 38.60 628.47 24-4 Leaves 2 34.76 10.56 25.91 229.14 10 28.32 23.51 30.92 517.19 50 21.28 30.14 34.25 728.73 24-5 Fruits 2 37.70 18.08 24.11 327.46 10 32.78 28.75 33.37 464.74 50 22.64 32.24 34.27 687.35 24-6 Flowers 2 36.56 13.44 22.74 294.42 10 33.66 20.40 32.96 406.96 50 25.39 30.11 39.43 614.75

TABLE-US-00045 TABLE 45 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 24 Heartleaf Houttuynia Heartleaf Houttuynia cordata Houttuynia Thunb. Compar- Heartleaf 3.23 MIC (%) Bacteria: 1  8.7 12.4 ative Houttuynia Example (other area) MIC (%) Fungi: 1 24-1 Whole plant 0.76 MIC (%) Bacteria: 0.0625 18.8 20.3 MIC (%) Fungi: 0.0625 24-2 Roots 0.81 MIC (%) Bacteria: 0.125 24.4 23.1 MIC (%) Fungi: 0.125 24-3 Stems 0.12 MIC (%) Bacteria: 0.5 10.9 16.7 MIC (%) Fungi: 0.5 24-4 Leaves 0.86 MIC (%) Bacteria: 0.5 17.2 10.4 MIC (%) Fungi: 0.5 24-5 Fruits 0.59 MIC (%) Bacteria: 0.5 18.8 17.2 MIC (%) Fungi: 0.5 24-6 Flowers 0.12 MIC (%) Bacteria: 0.5 17.4 17.8 MIC (%) Fungi: 0.5

EXAMPLE 25

Ulleungdo Liverleaf

[0126]

TABLE-US-00046 TABLE 46 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 25 Ulleungdo Hepatica Ulleungdo liverleaf maxima liverleaf (Nakai) Nakai 25-1 Whole plant 2 76.56 11.72 21.32 272.64 10 33.66 21.74 31.40 562.62 50 25.39 39.73 37.68 603.06 25-2 Roots 2 39.84 13.44 23.91 230.66 10 31.46 20.68 32.24 538.29 50 24.46 33.78 35.45 618.18 25-3 Stems 2 39.24 15.10 22.02 242.11 10 31.34 24.90 30.86 400.26 50 24.14 32.37 39.08 639.19 25-4 Leaves 2 34.09 15.35 25.02 287.66 10 31.67 25.97 33.55 484.59 50 23.61 32.33 34.12 652.27 25-5 Fruits 2 35.72 19.53 23.99 381.86 10 30.08 29.73 28.61 470.18 50 23.09 33.26 39.13 770.08 25-6 Flowers 2 39.83 13.44 20.51 308.72 10 27.62 20.40 32.72 443.95 50 20.16 30.11 37.02 706.41

TABLE-US-00047 TABLE 47 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 25 Ulleungdo Hepatica Ulleungdo liverleaf maxima liverleaf (Nakai) Nakai 25-1 Whole plant 0.45 MIC (%) Bacteria: 0.25 24.5 24.4 MIC (%) Fungi: 0.25 25-2 Roots 0.76 MIC (%) Bacteria: 0.0625 17.5 13.0 MIC (%) Fungi: 0.0625 25-3 Stems 0.42 MIC (%) Bacteria: 0.5 14.0 13.7 MIC (%) Fungi: 0.5 25-4 Leaves 0.21 MIC (%) Bacteria: 0.5 21.6 26.7 MIC (%) Fungi: 0.5 25-5 Fruits 0.84 MIC (%) Bacteria: 0.5 16.1  8.8 MIC (%) Fungi: 0.5 25-6 Flowers 0.53 MIC (%) Bacteria: 0.125 21.3 12.8 MIC (%) Fungi: 0.125

EXAMPLE 26

Chinese Buttercup

[0127]

TABLE-US-00048 TABLE 48 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 26 Chinese Ranunculus Chinese buttercup quelpaertensis buttercup (H. Lév.) Nakai Compar- Ranunculus 50 Ranunculus 89.24  1.34  1.54  22.34 ative ficaria Ficaria Example 26-1 Whole plant 2 39.57 15.51 22.72 395.30 10 32.67 29.69 29.50 575.83 50 24.86 33.60 39.40 650.79 26-2 Roots 2 39.86 11.34 22.72 312.22 10 29.07 22.16 29.50 451.69 50 24.83 35.64 39.40 738.08 26-3 Stems 2 38.29 18.13 22.72 213.87 10 28.34 29.98 29.50 493.07 50 22.42 30.93 39.40 799.14 26-4 Leaves 2 34.45 12.48 22.72 355.20 10 28.78 23.10 29.50 470.04 50 23.43 35.94 39.40 771.73 26-5 Fruits 2 35.91 18.09 22.72 256.23 10 28.13 22.78 29.50 579.79 50 21.52 34.15 39.40 667.50 26-6 Flowers 2 34.37 13.44 22.72 317.22 10 27.81 20.40 29.50 498.77 50 20.01 30.11 39.40 663.17

TABLE-US-00049 TABLE 49 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 26 Chinese Ranunculus Chinese buttercup quelpaertensis buttercup (H. Lév.) Nakai Compar- Ranunculus Ranunculus 6.67 MIC (%) Bacteria: 1  8.0  8.0 ative ficaria Ficaria Example MIC (%) Fungi: 1 26-1 Whole plant 0.46 MIC (%) Bacteria: 0.125 19.0 27.1 MIC (%) Fungi: 0.125 26-2 Roots 0.23 MIC (%) Bacteria: 0.5 10.2 15.9 MIC (%) Fungi: 0.5 26-3 Stems 0.34 MIC (%) Bacteria: 0.125 11.3 11.4 MIC (%) Fungi: 0.125 26-4 Leaves 0.67 MIC (%) Bacteria: 0.0625 15.3 13.0 MIC (%) Fungi: 0.0625 26-5 Fruits 0.46 MIC (%) Bacteria: 0.5 16.7 16.6 MIC (%) Fungi: 0.5 26-6 Flowers 0.45 MIC (%) Bacteria: 0.5 12.7 12.5 MIC (%) Fungi: 0.5

EXAMPLE 27

Tricuspidate Falsenettle

[0128]

TABLE-US-00050 TABLE 50 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 27 Tricuspidate Boehmeria Tricuspidate falsenettle tricuspis falsenettle (Hance) Makino Compar- Ramie 50 Boehmeria 99.86  2.34 1.72  87.22 ative nivea Example Compar- Tricuspidate 50 85.86 16.34 5.72 127.22 ative falsenettle Example (other area) 27-1 Whole plant 2 37.03 17.40 22.84 349.46 10 27.05 20.29 29.06 409.35 50 24.39 37.06 38.80 603.30 27-2 Roots 2 35.50 12.20 22.91 288.20 10 28.28 28.55 33.37 431.21 50 22.70 36.57 36.45 707.65 27-3 Stems 2 36.83 14.82 25.39 361.73 10 32.39 22.83 29.25 550.31 50 26.48 38.93 34.90 656.87 27-4 Leaves 2 39.50 18.49 23.84 255.08 10 32.30 27.16 32.21 532.98 50 20.05 34.72 36.47 727.63 27-5 Fruits 2 39.35 17.12 23.57 262.11 10 28.64 21.57 32.62 424.16 50 24.78 30.22 34.07 749.64 27-6 Flowers 2 34.37 13.44 26.04 394.81 10 27.81 20.40 30.38 459.42 50 20.01 30.11 34.82 651.09

TABLE-US-00051 TABLE 51 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 27 Tricuspidate Boehmeria Tricuspidate falsenettle tricuspis falsenettle (Hance) Makino Compar- Ramie Boehmeria 2.78 MIC (%) Bacteria: 1  8.4  9.4 ative nivea Example MIC (%) Fungi: 1 Compar- Tricuspidate 3.56 MIC (%) Bacteria: 1 11.6 11.7 ative falsenettle Example (other area) MIC (%) Fungi: 1 27-1 Whole plant 0.1 MIC (%) Bacteria: 0.125 18.6 22.1 MIC (%) Fungi: 0.125 27-2 Roots 0.63 MIC (%) Bacteria: 0.5 10.5 17.3 MIC (%) Fungi: 0.5 27-3 Stems 0.48 MIC (%) Bacteria: 0.0625 18.4 10.9 MIC (%) Fungi: 0.0625 27-4 Leaves 0.5 MIC (%) Bacteria: 0.5 26.8 22.6 MIC (%) Fungi: 0.5 27-5 Fruits 0.87 MIC (%) Bacteria: 0.125 16.2 12.1 MIC (%) Fungi: 0.125 27-6 Flowers 0.72 MIC (%) Bacteria: 0.125 10.3 17.3 MIC (%) Fungi: 0.125

EXAMPLE 28

Long-Calyx Pink

[0129]

TABLE-US-00052 TABLE 52 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 28 Long-calyx Dianthus Long-calyx pink longicalyx Miq. pink Compar- Carnation 50 Dianthus 76.48 13.66  2.65  50.69 ative Caryophyllus Example 28-1 Whole plant 2 39.25 23.43 23.55 283.74 10 32.46 28.42 33.89 414.73 50 25.16 35.96 36.66 745.27 28-2 Roots 2 38.91 20.24 25.92 360.57 10 27.38 27.00 33.90 484.73 50 24.09 35.56 37.56 604.21 28-3 Stems 2 35.70 22.44 22.02 256.20 10 30.77 33.18 28.90 425.05 50 23.59 39.52 35.28 675.27 28-4 Leaves 2 38.34 21.36 25.74 315.51 10 33.13 27.54 30.19 427.62 50 20.49 38.78 39.55 630.51 28-5 Fruits 2 34.49 25.21 22.53 324.59 10 30.00 32.59 28.47 436.64 50 23.30 37.99 39.61 700.96 28-6 Flowers 2 36.16 26.95 25.10 346.90 10 30.59 33.44 27.52 524.21 50 23.26 39.34 39.55 734.88

TABLE-US-00053 TABLE 53 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 28 Long-calyx Dianthus Long-calyx pink longicalyx Miq. pink Compar- Carnation Dianthus 7.56 MIC (%) Bacteria, Fungi: >2 10.9 10.2 ative Caryophyllus Example 28-1 Whole plant 0.49 MIC (%) Bacteria: 0.5 19.3 22.2 MIC (%) Fungi: 0.25 28-2 Roots 0.55 MIC (%) Bacteria: 1 27.7 19.5 MIC (%) Fungi: 0.5 28-3 Stems 0.69 MIC (%) Bacteria: 0.5 13.3 17.0 MIC (%) Fungi: 0.5 28-4 Leaves 0.63 MIC (%) Bacteria: 0.5 15.3 15.4 MIC (%) Fungi: 0.25 28-5 Fruits 0.78 MIC (%) Bacteria: 0.25 14.0 12.9 MIC (%) Fungi: 0.125 28-6 Flowers 0.79 MIC (%) Bacteria: 0.25 13.5 13.5 MIC (%) Fungi: 0.125

EXAMPLE 29

Curled Dock

[0130]

TABLE-US-00054 TABLE 54 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 29 Curled Rumex Curled dock crispus L. dock Compar- Garden 50 Rumex 86.74  3.84  2.15  35.42 ative dock acetosa L. Example Compar- Curled 50 Rumex 60.55 15.47 12.49 153.98 ative dock crispus L. Example (other area) 29-1 Whole plant 2 37.45 15.86 25.10 321.94 10 33.55 23.61 33.98 483.24 50 24.29 30.23 37.25 656.65 29-2 Roots 2 36.74 15.25 25.12 234.55 10 32.48 27.74 27.30 579.17 50 22.68 36.49 38.45 751.93 29-3 Stems 2 34.40 17.75 26.93 383.95 10 32.06 30.00 30.27 510.16 50 21.16 32.61 34.28 753.61 29-4 Leaves 2 35.96 14.81 26.55 223.18 10 28.51 22.56 30.86 474.09 50 21.58 37.25 34.04 723.59 29-5 Fruits 2 39.99 19.39 24.67 352.93 10 29.56 22.41 32.61 584.88 50 25.52 35.89 34.73 771.51 29-6 Flowers 2 39.30 18.83 25.07 339.29 10 27.17 28.19 32.38 418.58 50 23.67 36.36 36.15 729.03

TABLE-US-00055 TABLE 55 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 29 Curled Rumex Curled dock crispus L. dock Compar- Garden Rumex 9.93 MIC (%) Bacteria: 1 13.5 10.5 ative dock acetosa L. Example MIC (%) Fungi: 1 Compar- Curled Rumex 3.14 MIC (%) Bacteria: 0.5 13.3 14.1 ative dock crispus L. Example (other area) MIC (%) Fungi: 0.5 29-1 Whole plant 0.07 MIC (%) Bacteria: 0.125 27.5 20.2 MIC (%) Fungi: 0.125 29-2 Roots 0.1  MIC (%) Bacteria: 0.25 18.7 12.5 MIC (%) Fungi: 0.125 29-3 Stems 0.12 MIC (%) Bacteria: 0.125 13.1  9.3 MIC (%) Fungi: 0.0625 29-4 Leaves 0.07 MIC (%) Bacteria: 0.25 20.2 26.3 MIC (%) Fungi: 0.125 29-5 Fruits 0.24 MIC (%) Bacteria: 0.25 10.8 13.1 MIC (%) Fungi: 0.125 29-6 Flowers 0.05 MIC (%) Bacteria: 0.0625 14.0 10.8 MIC (%) Fungi: 0.0625

EXAMPLE 30

Erect St. Johnswort

[0131]

TABLE-US-00056 TABLE 56 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 30 Erect St. Hypericum Erect St. Johnswort erectum Thunb. Johnswort Compar- St John's 50 Hypericum 75.66  9.56  2.45  41.52 ative Wort Perforatum Example Compar- Erect St. 50 Hypericum 40.54 17.14  9.66 267.21 ative Johnswort erectum Thunb. Example (other area) 30-1 Whole plant 2 38.07 14.81 20.41 231.71 10 29.29 28.36 28.65 469.39 50 26.78 34.65 35.31 700.48 30-2 Roots 2 38.55 17.03 26.18 209.85 10 31.05 27.88 27.00 571.33 50 26.78 39.28 39.29 783.75 30-3 Stems 2 39.48 17.09 24.47 325.93 10 31.96 29.13 33.27 447.72 50 23.61 30.86 37.62 687.97 30-4 Leaves 2 35.92 18.17 24.59 292.75 10 29.46 27.46 29.57 462.78 50 22.99 35.11 34.57 638.97 30-5 Fruits 2 34.79 11.00 25.79 318.17 10 33.65 21.53 27.37 470.88 50 22.84 30.29 35.55 604.30 30-6 Flowers 2 35.12 15.09 21.85 241.03 10 28.48 25.98 29.90 538.52 50 21.89 34.36 39.29 666.36

TABLE-US-00057 TABLE 57 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 30 Erect St. Hypericum Erect St. Johnswort erectum Thunb. Johnswort Compar- St John's Hypericum 4.65 MIC (%) Bacteria: 1 11.2 9.2 ative Wort Perforatum Example MIC (%) Fungi: 1 Compar- Erect St. Hypericum 1.23 MIC (%) Bacteria: 1 17.7 16.5 ative Johnswort erectum Thunb. Example (other area) MIC (%) Fungi: 1 30-1 Whole plant 0.15 MIC (%) Bacteria: 0.25 26.4 22.9 MIC (%) Fungi: 0.125 30-2 Roots 0.07 MIC (%) Bacteria: 0.25 27.3 24.2 MIC (%) Fungi: 0.25 30-3 Stems 0.14 MIC (%) Bacteria: 0.125 13.0 9.8 MIC (%) Fungi: 0.0625 30-4 Leaves 0.04 MIC (%) Bacteria: 0.125 15.7 19.1 MIC (%) Fungi: 0.0625 30-5 Fruits 0.21 MIC (%) Bacteria: 0.25 21.1 19.3 MIC (%) Fungi: 0.25 30-6 Flowers 0.11 MIC (%) Bacteria: 0.125 22.6 15.6 MIC (%) Fungi: 0.125

EXAMPLE 31

Five-Leaf Gynostemma

[0132]

TABLE-US-00058 TABLE 58 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 31 Five-leaf Gynostemma Five-leaf gynostemma pentaphylla gynostemma (Thunb.) Makino Compar- Five-leaf 50 Gynostemma 87.21 17.45 12.14 214.55 ative gynostemma pentaphylla Example (other area) (Thunb.) Makino 31-1 Whole plant 2 35.80 11.06 24.25 274.50 10 27.39 24.54 28.71 439.60 50 25.00 30.42 38.95 698.74 31-2 Roots 2 38.47 11.34 24.85 378.08 10 27.92 23.92 31.52 596.78 50 26.27 38.88 38.95 654.92 31-3 Stems 2 34.24 14.05 20.83 324.60 10 28.03 22.57 33.80 507.38 50 23.41 36.12 39.31 673.64 31-4 Leaves 2 38.58 13.41 25.71 353.19 10 27.00 27.69 27.25 427.32 50 21.56 36.22 36.09 669.94 31-5 Fruits 2 36.30 16.31 25.21 310.69 10 32.13 23.49 31.08 432.14 50 24.46 37.41 37.61 650.81 31-6 Flowers 2 34.46 11.13 22.81 368.00 10 28.37 26.57 33.88 491.92 50 21.31 34.72 35.19 705.71

TABLE-US-00059 TABLE 59 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 31 Five-leaf Gynostemma Five-leaf gynostemma pentaphylla gynostemma (Thunb.) Makino Compar- Five-leaf Gynostemma 6.58 MIC (%) Bacteria: 1 15.7 14.1 ative gynostemma pentaphylla Example (other area) (Thunb.) Makino MIC (%) Fungi: 1 31-1 Whole plant 0.25 MIC (%) Bacteria: 0.25 24.7 25.9 MIC (%) Fungi: 0.25 31-2 Roots 0.12 MIC (%) Bacteria: 0.125  9.6 10.0 MIC (%) Fungi: 0.25 31-3 Stems 0.28 MIC (%) Bacteria: 0.25 11.3 15.7 MIC (%) Fungi: 0.25 31-4 Leaves 0.20 MIC (%) Bacteria: 0.25 13.3 17.7 MIC (%) Fungi: 0.25 31-5 Fruits 0.15 MIC (%) Bacteria: 0.125 25.2 25.8 MIC (%) Fungi: 0.0625 31-6 Flowers 0.18 MIC (%) Bacteria: 0.0625 10.6 13.0 MIC (%) Fungi: 0.125

EXAMPLE 32

Bird's Egg Cucumber

[0133]

TABLE-US-00060 TABLE 60 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 32 Bird's egg Melothria Bird's egg cucumber japonica cucumber (Thunb.) Maxim. Compar- Melothria 50 Melothria Solena 97.29 12.18  4.48  98.05 ative Heterophylla Example 32-1 Whole plant 2 35.22 17.75 23.05 301.04 10 31.77 22.83 28.32 512.22 50 22.04 34.98 39.30 711.80 32-2 Roots 2 36.97 18.04 26.07 341.54 10 30.34 27.19 33.34 447.46 50 24.10 30.40 39.20 718.95 32-3 Stems 2 35.67 13.82 25.71 315.42 10 27.26 23.31 27.54 525.52 50 21.62 32.95 36.30 662.05 32-4 Leaves 2 34.24 12.78 24.73 204.89 10 27.69 22.64 33.27 446.93 50 20.96 33.17 38.47 767.15 32-5 Fruits 2 38.43 12.62 25.20 255.15 10 50 24.11 30.13 38.19 651.54 32-6 Flowers 2 38.31 12.76 22.73 372.09 10 33.55 24.13 29.82 471.65 50 22.33 31.38 39.57 735.96

TABLE-US-00061 TABLE 61 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 32 Bird's egg Melothria Bird's egg cucumber japonica cucumber (Thunb.) Maxim Compar- Melothria Melothria Solena 8.01 MIC (%) Bacteria: >2 0.0 0.0 ative Heterophylla Example MIC (%) Fungi: >2 32-1 Whole plant 0.45 MIC (%) Bacteria: 0.25 12.8 17.0 MIC (%) Fungi: 0.125 32-2 Roots 0.96 MIC (%) Bacteria: 0.25 9.4 8.7 MIC (%) Fungi: 0.5 32-3 Stems 0.30 MIC (%) Bacteria: 0.25 17.2 18.2 MIC (%) Fungi: 0.25 32-4 Leaves 0.65 MIC (%) Bacteria: 0.125 10.5 13.6 MIC (%) Fungi: 0.25 32-5 Fruits 0.38 MIC (%) Bacteria: 0.5 18.9 13.3 MIC (%) Fungi: 1 32-6 Flowers 0.14 MIC (%) Bacteria: 1 13.9 9.5 MIC (%) Fungi: 1

EXAMPLE 33

Ulleungdo Rockcress

[0134]

TABLE-US-00062 TABLE 62 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 33 Ulleungdo Arabis Ulleungdo rockcress takesimana Nakai rockcress 33-1 Whole plant 2 37.72 13.67 21.77 278.76 10 31.23 26.76 33.86 514.61 50 22.29 30.87 36.51 708.03 33-2 Roots 2 39.47 16.47 23.64 370.23 10 32.97 27.30 32.13 553.07 50 25.75 35.29 37.43 768.17 33-3 Stems 2 34.64 16.00 24.31 352.19 10 33.96 21.11 32.72 462.20 50 25.46 32.06 35.53 773.27 33-4 Leaves 2 36.91 12.32 22.72 353.17 10 29.84 20.27 30.87 545.48 50 21.70 33.57 37.70 715.68 33-5 Fruits 2 37.95 18.60 24.64 323.92 10 33.61 25.03 28.92 455.97 50 22.34 31.34 36.77 787.93 33-6 Flowers 2 36.28 10.35 24.60 317.34 10 29.18 24.08 29.08 549.16 50 25.34 39.51 34.56 682.67

TABLE-US-00063 TABLE 63 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 33 Ulleungdo Arabis Ulleungdo rockcress takesimana Nakai rockcress 33-1 Whole plant 0.82 MIC (%) Bacteria: 1 13.8 19.5 MIC (%) Fungi: 0.5 33-2 Roots 0.64 MIC (%) Bacteria: 0.5 24.3 20.9 MIC (%) Fungi: 0.5 33-3 Stems 0.58 MIC (%) Bacteria: 0.25 9.4 11.6 MIC (%) Fungi: 0.5 33-4 Leaves 0.51 MIC (%) Bacteria: 0.125 26.8 24.7 MIC (%) Fungi: 0.25 33-5 Fruits 0.88 MIC (%) Bacteria: 1 8.3  9.6 MIC (%) Fungi: 0.5 33-6 Flowers 0.39 MIC (%) Bacteria: 0.25 10.2 11.6 MIC (%) Fungi: 0.25

EXAMPLE 34

Hedge Mustard

[0135]

TABLE-US-00064 TABLE 64 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 34 Hedge Sisymbrium Hedge Mustard officinale Mustard (L.) Scop. Compar- London 50 Sisymbrium 89.81  9.46  5.06  32.25 ative rocket Irio Example 34-1 Whole plant 2 38.49 10.86 25.18 292.14 10 32.11 25.67 27.04 517.63 50 23.22 32.02 37.38 676.68 34-2 Roots 2 37.61 19.84 20.59 254.44 10 30.49 23.52 32.49 466.11 50 21.30 38.86 39.81 751.79 34-3 Stems 2 35.49 10.10 22.45 303.26 10 27.41 29.96 31.77 461.07 50 26.31 32.69 34.05 658.52 34-4 Leaves 2 37.26 18.89 24.40 327.53 10 28.76 22.54 32.46 553.91 50 23.38 35.16 36.40 726.03 34-5 Fruits 2 34.66 12.44 22.45 260.84 10 32.71 29.56 30.57 578.41 50 20.47 35.81 36.02 666.84 34-6 Flowers 2 39.76 18.39 22.61 253.08 10 27.26 29.26 31.64 600.38 50 23.06 34.22 37.73 735.66

TABLE-US-00065 TABLE 65 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 34 Hedge Sisymbrium Hedge Mustard officinale Mustard (L.) Scop. Compar- London Sisymbrium 4.90 MIC (%) Bacteria: >2 8.8 8.5 ative rocket Irio Example MIC (%) Fungi: 1 34-1 Whole plant 0.38 MIC (%) Bacteria: 1 14.4 19.0 MIC (%) Fungi: 1 34-2 Roots 0.22 MIC (%) Bacteria: 0.125 8.8 10.2 MIC (%) Fungi: 0.125 34-3 Stems 0.41 MIC (%) Bacteria: 0.5 26.0 24.8 MIC (%) Fungi: 1 34-4 Leaves 0.62 MIC (%) Bacteria: 1 25.7 20.1 MIC (%) Fungi: 1 34-5 Fruits 0.87 MIC (%) Bacteria: 0.5 11.7 13.0 MIC (%) Fungi: 0.5 34-6 Flowers 0.99 MIC (%) Bacteria: 1 15.7 9.6 MIC (%) Fungi: 0.5

EXAMPLE 36

Asian Prince's Pine

[0136]

TABLE-US-00066 TABLE 66 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 36 Asian Chimaphila Asian prince's japonica Miq. prince's pine pine Compar- Prince's 50 Chimaphila 67.74  8.83  4.97 158.68 ative pine Umbellata Example 36-1 Whole plant 2 37.36 11.97 24.91 292.59 10 30.31 23.27 31.53 531.91 50 24.54 37.43 35.40 622.84 36-2 Roots 2 37.97 13.36 25.79 277.44 10 27.85 21.89 31.51 484.73 50 24.31 31.15 35.40 762.40 36-3 Stems 2 37.73 17.93 25.37 315.14 10 32.14 28.00 27.79 500.91 50 22.25 37.06 34.13 786.79 36-4 Leaves 2 36.80 11.10 21.58 226.74 10 27.02 24.99 33.79 577.91 50 21.58 39.31 39.12 603.85 36-5 Fruits 2 36.29 17.93 23.20 388.08 10 32.33 28.00 33.77 504.97 50 23.42 37.06 35.22 683.52 36-6 Flowers 2 39.54 19.93 21.80 233.90 10 29.28 21.51 30.81 471.50 50 20.52 39.96 39.91 788.63

TABLE-US-00067 TABLE 67 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 36 Asian Chimaphila Asian prince's japonica prince's pine Miq. pine Compar- Prince's Chimaphila 1.57 MIC (%) Bacteria: 1 10.0  9.4 ative pine Umbellata Example MIC (%) Fungi: 2 36-1 Whole plant 0.23 MIC (%) Bacteria: 0.13 23.2 21.3 MIC (%) Fungi: 0.06 36-2 Roots 0.46 MIC (%) Bacteria: 0.13 17.9 14.8 MIC (%) Fungi: 0.25 36-3 Stems 0.37 MIC (%) Bacteria: 0.5 10.4 17.1 MIC (%) Fungi: 0.25 36-4 Leaves 0.12 MIC (%) Bacteria: 0.25 13.0 14.9 MIC (%) Fungi: 0.13 36-5 Fruits 0.32 MIC (%) Bacteria: 0.5 11.1 15.7 MIC (%) Fungi: 1 36-6 Flowers 0.91 MIC (%) Bacteria: 0.06 24.0 23.7 MIC (%) Fungi: 0.13

EXAMPLE 37

Marlberry

[0137]

TABLE-US-00068 TABLE 68 Anti- Anti-wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 37 Marlberry Ardisia Marlberry japonica (Thunb.) Blume Compar- Christmas 50 Ardisia 80.02  4.89 3.54  77.70 ative berry Crenata Example Compar- Marlberry 50 Ardisia 52.96 13.58 9.48 286.38 ative (other area) japonica Example (Thunb.) Blume 37-1 Whole plant 2 37.79 12.10 21.69 245.22 10 29.02 23.20 31.43 498.31 50 20.60 31.19 38.29 721.29 37-2 Roots 2 37.02 19.20 23.88 306.75 10 32.02 21.99 31.12 476.21 50 20.68 37.64 34.32 660.18 37-3 Stems 2 34.12 14.23 25.90 349.78 10 27.97 29.99 27.83 571.61 50 22.81 37.74 37.63 717.21 37-4 Leaves 2 38.89 19.43 23.36 234.02 10 29.01 27.26 32.39 494.80 50 26.81 36.19 38.48 761.34 37-5 Fruits 2 39.24 13.08 21.27 206.40 10 32.42 23.46 32.25 573.25 50 21.03 38.66 36.56 767.58 37-6 Flowers 2 34.71 14.29 23.82 359.34 10 28.87 27.26 30.99 498.80 50 21.47 37.75 38.00 734.55

TABLE-US-00069 TABLE 69 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 37 Marlberry Ardisia Marlberry japonica (Thunb.) Blume Compar- Christmas Ardisia 2.25 MIC (%) Bacteria: 2 12.5 10.0 ative berry Crenata Example MIC (%) Fungi: >2 Compar- Marlberry Ardisia 1.31 MIC (%) Bacteria: 1 11.2 13.4 ative (other area) japonica Example (Thunb.) Blume MIC (%) Fungi: 1 37-1 Whole plant 0.20 MIC (%) Bacteria: 0.5 27.0 21.1 MIC (%) Fungi: 0.25 37-2 Roots 0.15 MIC (%) Bacteria: 0.13 16.3 10.0 MIC (%) Fungi: 0.25 37-3 Stems 0.99 MIC (%) Bacteria: 0.5 12.3 10.9 MIC (%) Fungi: 1 37-4 Leaves 0.69 MIC (%) Bacteria: 0.13 14.2  9.5 MIC (%) Fungi: 0.06 37-5 Fruits 0.17 MIC (%) Bacteria: 0.25 27.7 20.8 MIC (%) Fungi: 0.5 37-6 Flowers 0.70 MIC (%) Bacteria: 0.5 12.1 10.3 MIC (%) Fungi: 0.25

EXAMPLE 38

Spoon-Leaf Yellow Loosestrife

[0138]

TABLE-US-00070 TABLE 70 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 38 Spoon-leaf Lysimachia Spoon-leaf yellow loosestrife mauritiana Lam. yellow loosestrife Comparative Bog loosestrife 50 Lysimachia 71.24  8.82  1.52 181.01 Example Foenum-graecum 38-1 Whole plant 2 34.92 17.76 25.41 196.21 10 27.95 26.79 31.42 370.62 50 24.82 30.19 35.02 511.53 38-2 Roots 2 37.18 11.23 21.17 296.61 10 29.67 25.75 32.66 472.30 50 23.60 33.75 36.67 558.49 38-3 Stems 2 39.65 12.57 23.12 377.75 10 27.22 27.86 31.84 430.19 50 20.06 30.39 39.72 690.04 38-4 Leaves 2 39.38 12.42 23.77 170.49 10 29.01 21.94 29.04 421.56 50 14.30 38.24 39.74 588.19 38-5 Fruits 2 37.80 13.48 25.34 276.49 10 32.12 25.31 33.37 463.56 50 23.87 36.57 34.27 657.79 38-6 Flowers 2 26.54 19.89 24.85 397.78 10 18.88 29.42 29.17 523.38 50  8.91 39.16 39.73 780.79

TABLE-US-00071 TABLE 71 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 38 Spoon-leaf yellow Lysimachia Spoon-leaf loosestrife mauritiana Lam. yellow loosestrife Comparative Bog loosestrife Lysimachia 9.98 MIC (%) Bacteria: 2 11.2 15.8 Example Foenum-graecum MIC (%) Fungi: >2 38-1 Whole plant 0.17 MIC (%) Bacteria: 0.5 26.5 23.9 MIC (%) Fungi: 0.25 38-2 Roots 0.74 MIC (%) Bacteria: 0.5 16.5 11.2 MIC (%) Fungi: 0.5 38-3 Stems 0.03 MIC (%) Bacteria: 1 13.4 10.2 MIC (%) Fungi: 1 38-4 Leaves 0.72 MIC (%) Bacteria: 0.06 23.2 24.0 MIC (%) Fungi: 0.13 38-5 Fruits 0.83 MIC (%) Bacteria: 0.5 14.3 10.9 MIC (%) Fungi: 1 38-6 Flowers 0.34 MIC (%) Bacteria: 0.13  9.6  8.3 MIC (%) Fungi: 0.06

EXAMPLE 39

Climbing Hydrangea

[0139]

TABLE-US-00072 TABLE 72 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 39 Climbing Hydrangea petiolaris Climbing hydrangea Siebold & Zucc. hydrangea Comparative Bigleaf 50 Hydrangea Macrophylla 89.97  7.11  2.87 117.39 Example hydrangea 39-1 Whole plant 2 38.79 17.95 23.27 210.48 10 29.62 26.39 31.23 418.43 50 26.34 30.09 38.78 621.31 39-2 Roots 2 38.22 10.58 21.30 283.26 10 29.21 27.19 32.91 542.12 50 22.36 33.35 34.26 675.65 39-3 Stems 2 34.64 16.51 23.88 365.81 10 29.55 29.73 31.87 402.38 50 22.22 34.20 35.28 673.77 39-4 Leaves 2 39.53 12.38 26.32 343.01 10 22.33 25.77 31.37 436.24 50 13.11 38.75 44.01 703.27 39-6 Flowers 2 39.71 15.10 25.51 357.64 10 33.43 25.50 29.19 587.88 50 21.86 39.02 39.31 701.80

TABLE-US-00073 TABLE 73 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 39 Climbing Hydrangea petiolaris Climbing hydrangea Siebold & Zucc. hydrangea Comparative Bigleaf Hydrangea Macrophylla 3.95 MIC (%) Bacteria: 2 11.1 11.0 Example hydrangea MIC (%) Fungi: >2 39-1 Whole plant 0.13 MIC (%) Bacteria: 0.5 19.5 18.0 MIC (%) Fungi: 0.5 39-2 Roots 0.54 MIC (%) Bacteria: 1  9.9 10.0 MIC (%) Fungi: 0.5 39-3 Stems 0.61 MIC (%) Bacteria: 0.06 11.1 13.9 MIC (%) Fungi: 0.13 39-4 Leaves 0.90 MIC (%) Bacteria: 0.13 23.7 23.1 MIC (%) Fungi: 0.25 39-6 Flowers 0.37 MIC (%) Bacteria: 0.5 26.9 24.2 MIC (%) Fungi: 0.25

EXAMPLE 40

Stringy Stonecrop

[0140]

TABLE-US-00074 TABLE 74 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 40 Stringy Sedum sarmentosum Stringy stonecrop Bunge stonecrop Comparative Purple 50 Sedum Purpureum 76.08 13.10  2.38  23.78 Example stonecrop 40-1 Whole plant 2 35.39 10.57 16.54 253.81 10 31.83 23.48 28.53 329.93 50 33.75 26.13 29.54 584.07 40-2 Roots 2 37.72 14.22 26.29 229.26 10 31.98 23.42 27.48 600.32 50 26.74 30.35 34.39 743.58 40-3 Stems 2 34.77  8.52 15.43 214.85 10 33.20 19.09 22.27 467.36 50 32.38 25.45 28.18 527.02 40-4 Leaves 2 37.56 13.01 15.82 180.44 10 37.73 21.17 28.38 349.50 50 29.88 26.09 27.09 547.23 40-6 Flowers 2 38.53 15.35 24.01 311.16 10 31.46 28.33 32.01 518.92 50 26.18 35.04 35.48 645.94

TABLE-US-00075 TABLE 75 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 40 Stringy Sedum sarmentosum Stringy stonecrop Bunge stonecrop Comparative Purple Sedum Purpureum 6.94 MIC (%) Bacteria: >2, Fungi: >2 10.4 12.1 Example stonecrop 40-1 Whole plant 0.78 MIC (%) Bacteria: 1, Fungi: 2 21.7 21.7 40-2 Roots 0.21 MIC (%) Bacteria: 0.5, Fungi: 1 19.1 17.2 40-3 Stems 0.83 MIC (%) Bacteria: 1, Fungi: 2 13.3 12.1 40-4 Leaves 0.87 MIC (%) Bacteria: 1, Fungi: 2 11.8 12.1 40-6 Flowers 0.75 MIC (%) Bacteria: 0.5, Fungi: 0.5 27.3 21.6

EXAMPLE 41

Ulleungdo Stonecrop

[0141]

TABLE-US-00076 TABLE 76 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 41 Ulleungdo Sedum takesimense Ulleungdo stonecrop Nakai stonecrop Comparative Purple 50 Sedum Purpureum 76.08 13.10  2.38  23.78 Example stonecrop 41-1 Whole plant 2 33.73 11.80 20.36 253.41 10 31.83 23.25 22.52 469.56 50 29.27 29.39 29.28 580.53 41-2 Roots 2 35.86 13.83 24.41 238.58 10 29.79 23.23 27.70 524.91 50 23.36 35.49 36.60 619.40 41-3 Stems 2 35.95 18.89 24.77 253.27 10 31.13 22.43 33.45 415.51 50 22.66 33.46 39.79 742.65 41-4 Leaves 2 36.38 18.06 22.51 398.73 10 28.52 22.01 29.15 452.69 50 21.34 36.67 37.86 618.56 41-5 Fruits 2 37.60 13.45 26.81 334.49 10 29.85 27.09 32.93 426.94 50 25.50 35.10 37.42 780,63 41-6 Flowers 2 34.03 10.42 26.28 361.76 10 30.38 22.05 27.69 494.13 50 24.25 31.70 34.29 701.39

TABLE-US-00077 TABLE 77 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 41 Ulleungdo Sedum takesimense Ulleungdo stonecrop Nakai stonecrop Comparative Purple Sedum Purpureum 6.94 MIC (%) Bacteria: >2,  8.2 9.1 Example stonecrop Fungi: >2 41-1 Whole plant 0.99 MIC (%) Bacteria: 2, Fungi: 1 15.3 15.3 41-2 Roots 0.51 MIC (%) Bacteria: 0.5, Fungi: 0.25 10.4 12.1 41-3 Stems 0.17 MIC (%) Bacteria: 0.5, Fungi: 0.25 10.0 9.2 41-4 Leaves 0.53 MIC (%) Bacteria: 0.5, Fungi: 0.25 12.9 13.6 41-5 Fruits 0.40 MIC (%) Bacteria: 1, Fungi: 0.5 11.1 9.9 41-6 Flowers 0.77 MIC (%) Bacteria: 1, Fungi: 0.5 23.3 22.9

EXAMPLE 42

Foam Flower

[0142]

TABLE-US-00078 TABLE 78 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 42 Foam flower Tiarella polyphylla Foam flower 42-1 Whole plant 2 D. Don 32.92 10.33 17.50 281.20 10 32.25 17.53 23.93 361.49 50 33.53 24.49 31.33 581.22 42-2 Roots 2 40.72 11.87 20.72 283.04 10 32.08 26.27 31.65 442.89 50 29.20 32.84 36.40 649.06 42-3 Stems 2 40.52 11.95 25.70 344.61 10 36.44 22.98 27.56 476.99 50 32.09 33.52 38.77 684.26 42-4 Leaves 2 37.82 16.05 21.78 271.75 10 36.76 25.01 27.79 464.01 50 30.30 36.17 38.76 626.38 42-5 Fruits 2 41.19 18.76 21.46 350.48 10 33.53 27.78 27.73 403.43 50 29.19 36.53 36.44 695.07 42-6 Flowers 2 38.58 16.61 24.09 295.04 10 30.01 26.57 32.72 548.47 50 21.04 37.12 35.87 638.35

TABLE-US-00079 TABLE 79 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 42 Foam flower Tiarella polyphylla Foam flower D. Don 42-1 Whole plant 0.94 MIC (%) Bacteria: 0.5, Fungi: 1 9.8 11.8 42-2 Roots 0.85 MIC (%) Bacteria: 0.125, Fungi: 0.25 7.7 9.1 42-3 Stems 0.56 MIC (%) Bacteria: 0.125, Fungi: 0.25 10.1 11.0 42-4 Leaves 0.60 MIC (%) Bacteria: 0.125, Fungi: 0.25 8.2 8.7 42-5 Fruits 0.70 MIC (%) Bacteria: 0.25, Fungi: 0.5 8.6 8.8 42-6 Flowers 0.34 MIC (%) Bacteria: 0.25, Fungi: 0.5 10.5 8.2

EXAMPLE 43

East Asian Cinquefoil

[0143]

TABLE-US-00080 TABLE 80 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Aibutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 43 East Asian Potentilla chinensis East Asian cinquefoil Ser. cinquefoil Comparative Cinquefoil 50 Potentilla Fragarioides 88.07 16.32  6.56  27.58 Example 43-1 Whole plant 2 35.27 13.65 21.34 364.57 10 28.24 24.98 30.42 599.09 50 25.83 39.02 39.00 745.04 43-2 Roots 2 39.63 12.91 16.55 300.91 10 32.51 23.78 24.91 356.73 50 29.51 30.30 30.13 550.44 43-3 Stems 2 39.83 12.41 17.59 272.21 10 36.83 16.29 26.94 478.27 50 31.45 30.02 27.35 544.84 43-4 Leaves 2 39.98 10.47 20.57 155.81 10 36.24 18.67 23.16 323.39 50 29.05 26.30 32.57 603.21 43-5 Fruits 2 36.28 13.61 20.54 217.19 10 30.69 21.80 28.68 448.88 50 21.74 35.27 35.40 647.89 43-6 Flowers 2 39.95 11.70 18.58 268.01 10 32.13 21.05 26.12 362.91 50 32.13 30.29 28.11 574.09

TABLE-US-00081 TABLE 81 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Conc. Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample (ppm) name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 43 East Asian Potentilla chinensis East Asian cinquefoil Ser. cinquefoil Comparative Cinquefoil 50 Potentilla 8.99 MIC (%) Bacteria: 2, 10.7  9.1 Example Fragarioides Fungi: >2 43-1 Whole plant 2 0.43 MIC (%) Bacteria: 0.5, 27.4 22.0 10 Fungi: 1 50 43-2 Roots 2 0.48 MIC (%) Bacteria: 1, 12.3 14.3 10 Fungi: 2 50 43-3 Stems 2 0.71 MIC (%) Bacteria: 1, 10.4 12.0 10 Fungi: 2 50 43-4 Leaves 2 0.84 MIC (%) Bacteria: 1, 16.3 11.1 10 Fungi: 2 50 43-5 Fruits 2 0.33 MIC (%) Bacteria: 0.5, 26.5 27.2 10 Fungi: 1 50 43-6 Flowers 2 0.93 MIC (%) Bacteria; 1, 23.2 26.5 10 Fungi: 2 50

EXAMPLE 44

Indigobush Amorpha

[0144]

TABLE-US-00082 TABLE 82 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 44 Indigobush Amorpha fruticosa Indigobnsh Amorpha L. Amorpha Comparative Indigobush 50 68.12 10.71 12.24  98.27 Example Amorpha (other area) 44-1 Whole plant 2 38.07 13.33 22.43 374.92 10 32.00 24.16 31.54 472.24 50 23.50 39.80 39.92 777.80 44-2 Roots 2 39.58 10.22 26.46 385.24 10 30.90 29.26 27.46 506.11 50 20.89 38.05 39.67 779.60 44-3 Stems 2 34.50 16.37 25.79 284.40 10 27.46 23.20 27.90 574.37 50 25.70 37.89 36.57 678.03 44-4 Leaves 2 36.70 16.06 23.06 277.22 10 33.04 23.51 28.60 503.70 50 24.81 38.61 35.74 672.03 44-5 Fruits 2 37.14 10.13 22.82 269.86 10 29.98 23.29 29.47 504.28 50 21.54 31.80 37.19 693.12 44-6 Flowers 2 35.01 17.34 20.36 326.61 10 29.38 21.63 27.86 458.33 50 23.27 34.98 37.99 716.50

TABLE-US-00083 TABLE 83 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth Scientific English IC50 Anti-bacteria inhibition ring inhibition ring No. Sample name name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 44 Indigobush Amorpha fruticosa Indigobush Amorpha L. Amorpha Comparative Indigobush 2.45 MIC (%) Bacteria: 1 15.8 14.0 Example Amorpha MIC (%) Fungi: 2 (other area) 44-1 Whole plant 0.74 MIC (%) Bacteria: 0.25 26.6 24.6 MIC (%) Fungi: 0.5 44-2 Roots 0.03 MIC (%) Bacteria: 0.25  9.3  8.5 MIC (%) Fungi: 0.5 44-3 Stems 0.50 MIC (%) Bacteria: 0.5 13.5 14.0 MIC (%) Fungi: 0.5 44-4 Leaves 0.16 MIC (%) Bacteria: 0.5 23.1 25.9 MIC (%) Fungi: 0.5 44-5 Fruits 0.32 MIC (%) Bacteria: 1 14.1 13.1 MIC (%) Fungi: 0.5 44-6 Flowers 0.35 MIC (%) Bacteria: 1 26.6 27.6 MIC (%) Fungi: 0.5

EXAMPLE 45

Sericea Lespedeza

[0145]

TABLE-US-00084 TABLE 84 Whitening Anti-wrinkle Anti- Melanin Collagen inflammation Moisturizing Conc. Scientific English content synthesis Inhibition of NO HA synthesis No. Sample (ppm) name name (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 45 Sericea Lespedeza cuneata Sericea lespedeza (Dum. Cours.) G. Don lespedeza Comparative Leafy 50 Lespedeza Cyrtobotrya 90.93 10.72  4.67  74.92 Example lespedeza 45-1 Whole plant 2 36.68 15.09 21.51 352.11 10 33.46 29.94 27.22 437.21 50 23.34 30.60 36.63 602.02 45-2 Roots 2 39.64 19.22 23.59 278.18 10 27.50 23.80 31.62 488.76 50 21.68 32.52 36.64 622.98 45-3 Stems 2 37.77 14.84 24.66 361.91 10 28.94 23.27 30.43 406.33 50 20.17 36.76 37.81 609.27 45-4 Leaves 2 39.24 12.55 25.39 376.56 10 31.04 26.94 27.48 504.51 50 24.28 31.41 36.77 675.53 45-5 Fruits 2 37.34 19.97 22.68 307.41 10 31.81 29.49 29.60 402.24 50 22.30 32.23 37.52 735.82 45-6 Flowers 2 34.63 11.42 24,05 339.02 10 31.11 27.68 31.53 516.40 50 22.49 39.90 37.70 761.92

TABLE-US-00085 TABLE 85 Conc. Anti-oxidation Anti-bacteria No. Sample (ppm) Scientific name English name IC50 (%) MIC (%) Control group Vitamin C Hexanediol 7.5 ppm Bacteria: P.aeruginosa 2% Fungi: A.niger 1% 45 Sericea Lespedeza cuneata Sericea lespedeza (Dum. Cours.) G. Don. lespedeza Comparative Leafy Lespedeza 4.93 MIC (%) Bacteria: >2 Example lespedeza Cyrtobotrya MIC (%) Fungi: >2 45-1 Whole plant 2 0.90 MIC (%) Bacteria: 0.5 10 MIC (%) Fungi: 0.5 50 45-2 Roots 2 0.89 MIC (%) Bacteria: 0.125 10 MIC (%) Fungi: 0.5 50 45-3 Stems 2 0.68 MIC (%) Bacteria: 0.25 10 MIC (%) Fungi: 0.25 50 45-4 Leaves 2 0.22 MIC (%) Bacteria: 0.125 10 MIC (%) Fungi: 0.25 50 45-5 Fruits 2 0.78 MIC (%) Bacteria: 0.5 10 MIC (%) Fungi: 0.5 50 45-6 Flowers 2 0.03 MIC (%) Bacteria: 0.25 10 MIC (%) Fungi: 0.5 50 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth inhibition inhibition No. ring (mm) ring (mm) Untreated Untreated 0 mm 0 mm 45 Comparative 0.0 0.0 Example 45-1 8.8 9.4 45-2 13.6 12.0 45-3 11.9 14.9 45-4 9.1 10.0 45-5 12.5 12.4 45-6 8.6 9.4

EXAMPLE 46

Alfalfa

[0146]

TABLE-US-00086 TABLE 86 Whitening Anti-wrinkle Conc. Melanin Collagen synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) Control group Arbutin (200 ppm) TGFb (10 ppb) 35% 25% 46 Alfalfa Medicago sativa L. Alfalfa 46-1 Whole plant 2 38.32 13.70 10 31.97 21.20 50 24.28 30.18 46-2 Roots 2 36.65 18.39 10 29.15 27.16 50 20.35 34.26 46-3 Stems 2 39.90 15.39 10 27.33 22.35 50 23.61 33.40 46-4 Leaves 2 37.26 19.83 10 31.85 27.25 50 26.42 39.98 46-5 Fruits 2 36.02 15.79 10 32.92 28.89 50 23.11 39.98 46-6 Flowers 2 38.02 10.08 10 27.35 25.91 50 21.51 34.78 Anti-inflammation Moisturizing Inhibition of NO HA synthesis No. production (%) (%) L-NMMA (5 ppm) EGF (10 ppb) 28% 320% 46 46-1 23.48 265.24 28.33 595.91 35.78 701.01 46-2 23.94 337.91 33.82 498.90 36.27 731.25 46-3 24.36 385.97 31.45 538.06 35.94 611.31 46-4 22.65 262.66 29.45 525.95 37.97 720.95 46-5 25.60 310.30 32.42 559.89 36.37 789.47 46-6 23.91 371.58 28.98 500.28 36.66 770.21

TABLE-US-00087 TABLE 87 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth Anti-oxidation Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name IC50 (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P.aeruginosa 2% 0 mm 0 mm Fungi: A.niger 1% 46 Alfalfa Medicago sativa L. Alfalfa 46-1 Whole plant 0.72 MIC (%) Bacteria: 1 14.5 23.6 MIC (%) Fungi: 1 46-2 Roots 0.62 MIC (%) Bacteria: 0.25 18.2 12.1 MIC (%) Fungi: 1 46-3 Stems 1.00 MIC (%) Bacteria: 1 18.0 15.5 MIC (%) Fungi: 0.5 46-4 Leaves 0.62 MIC (%) Bacteria: 0.25 18.8 19.5 MIC (%) Fungi: 0.25 46-5 Fruits 0.61 MIC (%) Bacteria: 0.25 9.6 9.1 MIC (%) Fungi: 0.5 46-6 Flowers 0.39 MIC (%) Bacteria: 0.25 21.5 23.3 MIC (%) Fungi: 0.25

EXAMPLE 47

Amur Vetch

[0147]

TABLE-US-00088 TABLE 88 Whitening Anti-wrinkle Conc. Melanin Collagen synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) Control group Arbutin (200 ppm) TGFb (10 ppb) 35% 25% 47 Amur vetch Vicia amurensis Amur vetch Oett. Comparative Broad bean 50 Vicia Faba 99.44 4.07 Example 47-1 Whole plant 2 39.97 17.99 10 30.18 21.04 50 22.69 33.43 47-2 Roots 2 39.26 12.69 10 30.17 20.13 50 21.97 38.61 47-3 Stems 2 38.08 17.51 10 33.66 26.64 50 20.74 37.72 47-4 Leaves 2 37.90 11.37 10 30.76 20.91 50 22.69 33.04 47-5 Fruits 2 37.86 13.37 10 27.59 25.76 50 24.21 36.96 47-6 Flowers 2 34.62 19.57 10 32.38 25.45 50 24.05 36.86 Anti-inflammation Moisturizing Inhibition of NO HA synthesis No. production (%) (%) L-NMMA (5 ppm) EGF (10 ppb) 28% 320% 47 Comparative 2.33 48.67 Example 47-1 26.68 270.24 33.37 420.30 34.06 658.79 47-2 24.72 352.08 29.46 579.68 35.13 613.79 47-3 22.23 300.87 32.11 524.86 37.94 678.84 47-4 26.05 350.85 31.08 515.02 34.10 789.15 47-5 21.96 291.96 27.05 535.22 37.24 773.53 47-6 23.17 382.55 32.58 497.85 35.98 624.42

TABLE-US-00089 TABLE 89 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Anti-oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P.aeruginosa 2% 0 mm 0 mm Fungi: A.niger 1% 47 Amur vetch Vicia amurensis Amur vetch Oett. Comparative Broad bean Vicia Faba 5.01 MIC (%) Bacteria: >2 8.6 9.2 Example MIC (%) Fungi: 2 47-1 Whole plant 0.63 MIC (%) Bacteria: 1 23.7 21.7 MIC (%) Fungi: 0.5 47-2 Roots 0.86 MIC (%) Bacteria: 0.25 26.6 21.4 MIC (%) Fungi: 0.5 47-3 Stems 0.57 MIC (%) Bacteria: 1 27.2 17.3 MIC (%) Fungi: 0.5 47-4 Leaves 0.40 MIC (%) Bacteria: 0.5 23.7 21.8 MIC (%) Fungi: 0.5 47-5 Fruits 0.28 MIC (%) Bacteria: 1 15.1 9.7 MIC (%) Fungi: 0.5 47-6 Flowers 0.30 MIC (%) Bacteria: 1 18.0 18.9 MIC (%) Fungi: 0.5

EXAMPLE 48

Hairy Purple Loosestrife

[0148]

TABLE-US-00090 TABLE 90 Whitening Anti-wrinkle Anti-inflammation Moisturizing Conc. Melanin Collagen synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control group Arbutin (200 ppm) TGFb (10 ppb) L-NMMA (5 ppm) EGF(10 ppb) 35% 25% 28% 320% 48 Hairy purple Lythrum salicaria L. Hairy purple loosestrife loosestrife 48-1 Whole plant 2 37.35 17.25 22.56 349.99 10 35.58 26.34 24.34 559.12 50 30.49 31.64 28.61 687.02 48-2 Roots 2 35.02 13.53 22.55 307.92 10 30.53 25.75 27.19 468.32 50 21.03 38.59 37.53 662.99 48-3 Stems 2 35.39 12.59 26.40 266.77 10 32.88 22.87 27.52 495.52 50 23.41 39.46 35.09 620.57 48-4 Leaves 2 38.33 12.92 24.19 252.16 10 27.28 27.70 32.91 511.41 50 21.09 33.61 38.26 708.37 48-5 Fruits 2 34.37 10.52 22.03 381.00 10 31.72 28.95 29.90 476.07 50 21.29 38.03 39.07 740.05 48-6 Flowers 2 38.25 15.18 20.83 309.53 10 30.12 19.22 30.31 404.98 50 20.58 29.24 37.94 763.26 48-7 Shoots 2 39.93 11.12 20.26 306.27 10 33.81 23.68 33.16 534.68 50 24.16 32.23 39.67 722.82

TABLE-US-00091 TABLE 91 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Anti-oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P.aeruginosa 2% 0 mm 0 mm Fungi: A.niger 1% 48 Hairy purple Lythrum salicaria L. Hairy purple loosestrife loosestrife 48-1 Whole plant 1.95 MIC (%) Bacteria: 0.25, Fungi:0.25 16.2 8.9 48-2 Roots 0.21 MIC (%) Bacteria: 1, Fungi: 0.125 24.8 18.7 48-3 Stems 0.75 MIC (%) Bacteria: 2, Fungi: 0.5 21.2 8.9 48-4 Leaves 0.95 MIC (%) Bacteria: 0.5, Fungi: 1 15.2 26.1 48-5 Fruits 0.56 MIC (%) Bacteria: 2, Fungi: 0.5 14.6 15.3 48-6 Flowers 0.59 MIC (%) Bacteria: 1, Fungi: 0.25 27.2 26.3 48-7 Shoots 0.80 MIC (%) Bacteria: 2, Fungi: 1 11.6 13.5

EXAMPLE 49

South Enchanter's Nightshade

[0149]

TABLE-US-00092 TABLE 92 Whitening Anti-wrinkle Conc. Melanin Collagen synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) Control group Arbutin (200 ppm) TGFb (10 ppb) 35% 25% 49 South Circaea mollis South enchanter's Siebold & enchanter's nightshade Zucc. nightshade Comparative Cordata 50 Circaea Cordata Cordata 84.92 15.76 Example enchanter's nightshade 49-1 Whole plant 2 37.51 16.04 10 33.85 22.68 50 21.52 31.88 49-2 Roots 2 35.69 19.75 10 31.89 24.22 50 20.58 34.35 49-3 Stems 2 39.27 11.89 10 29.58 21.06 50 20.88 34.70 49-4 Leaves 2 34.92 17.84 10 30.89 21.26 50 24.75 31.58 49-5 Fruits 2 37.92 17.63 10 30.21 25.50 50 20.77 33.25 49-6 Flowers 2 38.52 17.02 10 32.44 38.82 50 20.91 33.14 Anti-inflammation Moisturizing Inhibition of NO HA synthesis No. production (%) (%) L-NMMA (5 ppm) EGF (10 ppb) 28% 320% 49 Comparative 2.11 82.40 Example 49-1 21.59 400.02 25.26 478.55 27.96 767.34 49-2 25.72 355.34 28.16 447.18 34.60 654.97 49-3 21.43 363.29 31.27 409.44 36.11 737.06 49-4 26.40 357.85 29.24 484.90 38.05 621.21 49-5 22.60 280.84 33.99 529.37 38.86 789.95 49-6 22.50 384.53 27.66 468.93 37.28 614.21

TABLE-US-00093 TABLE 93 Anti-oxidation IC50 No. Sample Scientific name English name (%) Control group Vitamin C 7.5 ppm 49 South Circaea mollis South enchanter's Siebold & enchanter's nightshade Zucc. nightshade Comparative Cordata Circaea Cordata Cordata 3.81 Example enchanter's nightshade 49-1 Whole plant 0.22 49-2 Roots 0.67 49-3 Stems 0.03 49-4 Leaves 0.03 49-5 Fruits 0.93 49-6 Flowers 0.21 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth Anti-bacteria inhibition ring inhibition ring No. MIC (%) (mm) (mm) Hexanediol Untreated Untreated Bacteria: P.aeruginosa 2% 0 mm 0 mm Fungi: A.niger 1% 49 Comparative MIC (%) Bacteria: 2, Fungi: 2 11.4 8.2 Example 49-1 MIC (%) Bacteria: 0.25, Fungi: 25.2 20.8 0.125 49-2 MIC (%) Bacteria: 1, Fungi: 0.125 14.8 13.9 49-3 MIC (%) Bacteria: 0.5, Fungi: 1 27.5 19.6 49-4 MIC (%) Bacteria: 1, Fungi: 1 9.4 14.9 49-5 MIC (%) Bacteria: 2, Fungi: 0.5 12.6 26.4 49-6 MIC (%) Bacteria: 0.5, Fungi: 15.2 19.8 0.125

EXAMPLE 50

Long-Seed Willowherb

[0150]

TABLE-US-00094 TABLE 94 Whitening Conc. Melanin No. Sample (ppm) Scientific name English name content (%) Control group Arbutin (200 ppm) 35% 50 Long-seed Epilobium Long-seed willowherb pyrricholophum willowherb Franch. & Sav. Comparative Willow herb 50 Epilobium 77.09 Example Angustifolium 50-1 Whole plant 2 37.44 10 36.73 50 30.18 50-2 Roots 2 36.95 10 27.26 50 23.37 50-3 Stems 2 37.70 10 28.71 50 20.98 50-4 Leaves 2 34.31 10 29.40 50 22.55 50-5 Fruits 2 36.94 10 31.57 50 21.68 50-6 Flowers 2 37.73 10 31.02 50 21.89 Anti-wrinkle Anti-inflammation Moisturizing Collagen synthesis Inhibition of NO HA synthesis No. (% of control) production (%) (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF (10 ppb) 320% 50 Comparative 4.19 3.89 83.23 Example 50-1 10.27 20.52 294.93 16.25 24.97 337.84 25.92 30.19 440.70 50-2 16.83 22.42 252.06 28.23 28.55 577.26 36.60 39.95 602.36 50-3 10.49 22.70 356.82 29.58 27.27 419.73 32.44 36.82 656.87 50-4 13.21 23.28 309.86 22.99 31.42 497.72 36.94 38.17 608.79 50-5 10.39 21.86 292.71 29.84 30.92 408.55 31.70 35.24 759.80 50-6 18.51 26.27 272.12 27.36 31.85 523.59 35.72 37.51 779.15

TABLE-US-00095 TABLE 95 Anti-oxidation IC50 Anti-bacteria No. Sample Scientific name English name (%) MIC (%) Control group Vitamin C Hexanediol 7.5 ppm Bacteria: P.aeruginosa 2% Fungi: A.niger 1% 50 Long-seed Epilobium Long-seed willowherb pyrricholophum willowherb Franch. & Sav. Comparative Willow herb Epilobium 3.34 MIC (%) Bacteria, Fungi: >2 Example Angustifolium 50-1 Whole plant 1.76 MIC (%) Bacteria: 2, Fungi: 0.5 50-2 Roots 0.61 MIC (%) Bacteria: 1, Fungi: 0.125 50-3 Stems 0.76 MIC (%) Bacteria: 1, Fungi: 0.5 50-4 Leaves 0.91 MIC (%) Bacteria: 1, Fungi: 1 50-5 Fruits 0.95 MIC (%) Bacteria: 2, Fungi: 0.5 50-6 Flowers 0.49 MIC (%) Bacteria: 1, Fungi: 0.25 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth inhibition ring inhibition ring No. (mm) (mm) Untreated 0 mm Untreated 0 mm 50 Comparative 8.4 9.6 Example 50-1 18.7 18.0 50-2 27.2 26.2 50-3 14.8 21.7 50-4 18.7 16.9 50-5 20.9 14.4 50-6 23.3 14.4

EXAMPLE 51

Evening Primrose

[0151]

TABLE-US-00096 TABLE 96 Whitening Conc. Melanin No. Sample (ppm) Scientific name English name content (%) Control group Arbutin (200 ppm) 35% 51 Evening Primrose Oenothera biennis L Evening Primrose Comparative Baby Evening 50 Oenothera Laciniata 94.61 Example Primrose Comparative Evening Primrose 50 57.79 Example (other area) 51-1 Whole plant 2 39.09 10 32.01 50 25.30 51-2 Roots 2 36.95 10 30.69 50 23.42 51-3 Stems 2 36.29 10 28.25 50 26.83 51-4 Leaves 2 39.62 10 31.30 50 22.36 51-5 Fruits 2 38.13 10 34.15 50 31.67 51-6 Flowers 2 37.11 10 36.75 50 33.18 Anti-wrinkle Anti-inflammation Moisturizing Collagen synthesis Inhibition of NO HA synthesis No. (% of control) production (%) (%) TGFb (10 ppb) L-NMMA (5 ppm) EGF (10 ppb) 25% 28% 320% 51 Comparative 11.04 1.55 38.49 Example Comparative 19.76 13.57 223.99 Example 51-1 13.95 25.50 326.64 29.55 29.67 429.82 39.57 34.21 640.63 51-2 18.88 22.30 251.32 27.94 30.80 541.90 39.36 34.68 688.18 51-3 14.69 21.01 339.07 23.22 31.45 492.49 36.18 37.45 788.18 51-4 12.94 23.12 354.45 20.50 32.29 516.72 28.41 35.01 712.28 51-5 14.06 23.22 330.97 20.56 31.46 539.64 27.26 35.17 630.25 51-6 14.74 20.89 236.47 16.42 25.16 361.37 30.24 30.64 437.40

TABLE-US-00097 TABLE 97 Anti-oxidation IC50 Anti-bacteria No. Sample Scientific name English name (%) MIC (%) Control group Vitamin C Hexanediol 2% 7.5 ppm 51 Evening Primrose Oenothera biennisL. Evening Bacteria: P.aeruginosa Primrose Comparative Baby Evening Oenothera Laciniata 5.14 Fungi: A.niger 1% Example Primrose Comparative Evening Primrose 2.21 Example (other area) 51-1 Whole plant 0.44 MIC (%) Bacteria: 2, Fungi: >2 51-2 Roots 0.55 MIC (%) Bacteria: 2, Fungi: 1 51-3 Stems 0.66 MIC (%) Bacteria: 0.25, Fungi: 0.125 51-4 Leaves 0.62 MIC (%) Bacteria: 1, Fungi: 0.125 51-5 Fruits 0.86 MIC (%) Bacteria: 1, Fungi: 0.5 51-6 Flowers 0.37 MIC (%) Bacteria: 1, Fungi: 1 MIC (%) Bacteria: 2, Fungi: 0.5 MIC (%) Bacteria: 1, Fungi: 0.25 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth inhibition ring inhibition ring No. (mm) (mm) Untreated Untreated 0 mm 0 mm 51 Comparative 8.6 8.5 Example Comparative 14.8 15.3 Example 51-1 25.1 24.6 51-2 14.4 14.6 51-3 17.5 11.3 51-4 24.6 22.5 51-5 17.4 10.2 51-6 19.5 26.2

EXAMPLE 52

Stolon Golden Saxifrage

[0152]

TABLE-US-00098 TABLE 98 Whitening Anti-wrinkle Anti-inflammation Moisturizing Conc. Melanin Collagen synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control group Arbutin (200 ppm) TGFb (10 ppb) L-NMMA (5 ppm) EGF (10 ppb) 35% 25% 28% 320% 52 Stolon golden Chrysosplenium Stolon golden saxifrage flagelliferum saxifrage F. Schmidt 52-1 Whole plant 2 36.59 14.26 21.63 231.94 10 32.17 20.06 29.07 540.11 50 21.60 31.87 35.53 658.17 52-2 Roots 2 36.59 19.79 23.84 386.69 10 29.86 22.99 29.34 565.77 50 20.02 39.37 35.88 712.63 52-3 Stems 2 36.03 17.00 20.24 350.77 10 30.24 22.42 27.65 585.34 50 24.79 37.40 35.59 732.85 52-4 Leaves 2 36.75 17.43 24.32 284.59 10 30.74 27.82 30.61 438.64 50 25.97 36.92 38.66 781.17 52-5 Fruits 2 36.98 12.00 24.68 244.28 10 29.57 20.62 32.56 471.22 50 20.64 33.33 36.77 727.23 52-6 Flowers 2 37.74 19.59 24.68 309.36 10 31.52 29.23 33.48 474.74 50 24.28 34.00 39.22 607.46

TABLE-US-00099 TABLE 99 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth Anti-oxidation Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name IC50 (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P.aeruginosa 2% 0 mm 0 mm Fungi: A.niger 1% 52 Stolon golden Chrysosplenium Stolon golden saxifrage flagelliferum F. saxifrage Schmidt 52-1 Whole plant 0.80 MIC (%) Bacteria: 2, Fungi: 0.5 16.9 18.5 52-2 Roots 0.02 MIC (%) Bacteria: 0.25, Fungi: 1 24.2 21.3 52-3 Stems 0.22 MIC (%) Bacteria: 1, Fungi: 1 12.2 17.2 52-4 Leaves 0.34 MIC (%) Bacteria: 0.5, Fungi: 0.25 17.8 10.9 52-5 Fruits 0.01 MIC (%) Bacteria: 2, Fungi: 2 11.0 14.2 52-6 Flowers 0.89 MIC (%) Bacteria: 0.5, Fungi: 0.5 24.5 25.0

EXAMPLE 53

Serrate-Petal Rockfoil

[0153]

TABLE-US-00100 TABLE 100 Conc. Whitening Melanin No. Sample (ppm) Scientific name English name content (%) Control group Arbutin (200 ppm) 35% 53 Serrate-petal Saxifraga fortunei Serrate-petal rockfoil var. incisolobata rockfoil (Engl. & Irmsch.) Nakai Comparative Saxifrage 50 Saxifraga Sarmentosa 75.71 Example 53-1 Whole plant 2 36.24 10 31.41 50 21.94 53-2 Roots 2 37.48 10 33.12 50 24.52 53-3 Stems 2 37.19 10 32.02 50 22.65 53-4 Leaves 2 35.51 10 33.45 50 20.29 53-5 Fruits 2 37.26 10 29.18 50 23.17 53-6 Flowers 2 36.25 10 33.27 50 25.30 Anti-wrinkle Anti-inflammation Collagen synthesis Inhibition of NO Moisturizing No. (% of control) production (%) HA synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF(10 ppb) 320% 53 Comparative 2.97 2.30 81.06 Example 53-1 14.99 24.26 304.59 29.39 29.47 432.81 36.98 36.25 722.55 53-2 14.15 21.98 391.12 24.91 33.02 485.04 36.48 36.27 718.62 53-3 16.78 21.00 348.27 25.75 31.39 535.01 32.13 34.94 680.48 53-4 11.60 26.25 221.32 26.97 30.95 538.37 38.26 37.93 789.68 53-5 11.61 26.72 389.54 22.17 29.96 524.36 33.69 35.59 600.26 53-6 15.69 21.10 319.30 22.89 32.94 501.22 31.21 34.93 739.52

TABLE-US-00101 TABLE 101 Anti-oxidation No. Sample Scientific name English name IC50 (%) Control group Vitamin C 7.5 ppm 53 Serrate-petal rockfoil Saxifraga fortunei var. Serrate-petal incisolobata (Engl. & Irmsch.) rockfoil Nakai Comparative Saxifrage Saxifraga Sarmentosa 4.65 Example 53-1 Whole plant 0.18 53-2 Roots 0.25 53-3 Stems 0.69 53-4 Leaves 0.07 53-5 Fruits 0.12 53-6 Flowers 0.12 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth No. Anti-bacteria MIC (%) inhibition ring (mm) inhibition ring (mm) Hexanediol Untreated 0 mm Untreated 0 mm Bacteria: P.aeruginosa 2% Fungi: A.niger 1% 53 Comparative MIC (%) Bacteria: 2/Fungi: >2 10.5 10.8 Example 53-1 MIC (%) Bacteria: 1/Fungi: 1 26.1 23.1 53-2 MIC (%) Bacteria: 2, Fungi: 1 8.8 10.9 53-3 MIC (%) Bacteria: 1, Fungi: 1 18.0 23.1 53-4 MIC (%) Bacteria: 0.25, Fungi: 0.25 11.5 9.7 53-5 MIC (%) Bacteria: 2, Fungi: 1 25.6 18.3 53-6 MIC (%) Bacteria: 0.5, Fungi: 0.5 16.1 16.3

EXAMPLE 54

Ulleungdo Deadnettle

[0154]

TABLE-US-00102 TABLE 102 Conc. Whitening Melanin No. Sample (ppm) Scientific name English name content (%) Control Group Arbutin (200 ppm) 35% 54 Ulleungdo Lamium takesimense Ulleungdo deadnettle NAKAI. deadnettle Comparative Deadnettle 50 Lamium Album 78.41 Example 54-1 Whole plant 2 35.02 10 28.57 50 23.28 54-2 Roots 2 37.32 10 27.09 50 25.40 54-3 Stems 2 37.23 10 33.64 50 26.37 54-4 Leaves 2 34.00 10 30.87 50 26.75 54-5 Fruits 2 34.98 10 27.73 50 20.69 54-6 Flowers 2 34.02 10 29.85 50 26.21 Anti-wrinkle Anti-inflammation Collagen synthesis Inhibition of Moisturizing No. (% of control) NO production (%) HA synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF (10 ppb) 320% 54 Comparative 10.29 3.06 54.28 Example 54-1 11.63 26.42 384.50 29.08 32.93 501.69 38.86 37.60 687.74 54-2 13.70 20.03 377.20 24.49 38.40 537.75 33.48 39.61 703.10 54-3 17.90 21.52 348.69 22.15 31.40 452.58 36.21 37.74 696.56 54-4 13.25 20.88 270.20 25.66 31.85 459.14 32.55 35.21 794.73 54-5 12.86 22.31 288.52 25.92 30.60 541.29 37.78 38.43 683.72 54-6 11.57 24.33 364.82 26.66 29.10 590.29 38.76 34.26 793.67

TABLE-US-00103 TABLE 103 Anti-oxidation No. Sample Scientific name English name IC50 (%) Control group Vitamin C 7.5 ppm 54 Ulleungdo Lamium takesimense Ulleungdo deadnettle NAKAI. deadnettle Comparative Deadnettle Lamium Album 5.58 Example 54-1 Whole plant 0.25 54-2 Roots 0.30 54-3 Stems 0.97 54-4 Leaves 0.50 54-5 Fruits 0.52 54-6 Flowers 0.70 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth Anti-bacteria inhibition ring inhibition ring No. MIC (%) (mm) (mm) Hexanediol Untreated 0 mm Untreated 0 mm Bacteria: P.aeruginosa 2% Fungi: A.niger 1% 54 Comparative MIC (%) Bacteria: 2/Fungi: 2 9.2 8.7 Example 54-1 MIC (%) Bacteria: 0.5/Fungi: 0.25 18.7 18.9 54-2 MIC (%) Bacteria: 2, Fungi: 1 23.6 20.8 54-3 MIC (%) Bacteria: 1, Fungi: 1 13.3 15.2 54-4 MIC (%) Bacteria: 0.125, Fungi: 0.5 15.3 14.2 54-5 MIC (%) Bacteria: 1, Fungi: 0.25 8.3 15.5 54-6 MIC (%) Bacteria: 1, Fungi: 0.5 17.8 21.1

EXAMPLE 55

Island Ninebark

[0155]

TABLE-US-00104 TABLE 104 Conc. Whitening Melanin No. Sample (ppm) Scientific name English name content (%) Control group Arbutin (200 ppm) 35% 55 Island ninebark Physocarpus insularis Island ninebark Comparative Amur ninebark 50 Amurensis 84.95 Example 55-1 Whole plant 2 39.08 10 31.54 50 21.39 55-2 Roots 2 35.36 10 27.67 50 25.98 55-3 Bark 2 37.40 10 31.43 50 22.56 55-4 Leaves 2 38.97 10 32.73 50 26.73 55-5 Fruits 2 34.72 10 31.37 50 26.66 55-6 Flowers 2 39.69 10 30.86 50 24.56 Anti-wrinkle Anti-inflammation Collagen synthesis Inhibition of NO Moisturizing HA No. (% of control) production (%) synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF (10 ppb) 320% 55 Comparative 12.40 1.37 37.94 Example 55-1 19.41 24.50 209.87 21.11 29.82 530.10 38.46 38.03 737.07 55-2 11.77 23.29 279.45 22.89 28.21 431.74 37.91 34.96 720.19 55-3 16.95 21.42 206.82 20.25 31.85 443.81 35.96 38.13 661.64 55-4 17.15 23.07 300.42 21.55 30.40 570.62 35.28 38.69 755.51 55-5 11.53 24.42 349.79 25.60 29.22 591.94 35.49 39.44 653.78 55-6 17.90 20.14 396.18 28.70 28.45 504.18 30.21 35.02 747.26

TABLE-US-00105 TABLE 105 Anti-oxidation Anti-bacteria No. Sample Scientific name English name IC50 (%) MIC (%) Control group Vitamin C 7.5 ppm Hexanediol Bacteria: P.aeruginosa 2% Fungi: A.niger 1% 55 Island ninebark Physocarpus insularis Island ninebark Comparative Amur ninebark Physocarpus Amurensis 3.94 MIC (%) Bacteria: >2/Fungi: >2 Example 55-1 Whole plant 0.84 MIC (%) Bacteria: 0.5/Fungi: 0.25 55-2 Roots 0.42 MIC (%) Bacteria: 2, Fungi: 2 55-3 Bark 0.03 MIC (%) Bacteria: 0.25, Fungi: 0.125 55-4 Leaves 0.98 MIC (%) Bacteria: 1, Fungi: 0.5 55-5 Fruits 0.59 MIC (%) Bacteria: 1, Fungi: 1 55-6 Flowers 0.43 MIC (%) Bacteria: 2, Fungi: 2 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth No. inhibition ring (mm) inhibition ring (mm) Untreated 0 mm Untreated 0 mm 55 Comparative 9.2 8.1 Example 55-1 21.6 24.7 55-2 13.9 16.8 55-3 17.9 23.3 55-4 15.7 13.3 55-5 8.6 22.7 55-6 25.4 27.8

EXAMPLE 56

Island Corydalis

[0156]

TABLE-US-00106 TABLE 106 Conc. Whitening No. Sample (ppm) Scientific name English name Melanin content (%) Control group Arbutin (200 ppm) 35% 56 Island corydalis Corydalis ilistipes Nakai Island corydalis Comparative Korean corydalis 50 Corydalis Turtschaninovii 91.92 Example 56-1 Whole plant 2 39.64 10 28.94 50 25.48 56-2 Roots 2 39.12 10 33.27 50 20.60 56-3 Stems 2 34.76 10 33.94 50 26.66 56-4 Leaves 2 38.58 10 27.73 50 21.32 56-5 Fruits 2 35.26 10 33.45 50 25.50 56-6 Flowers 2 38.37 10 28.41 50 25.38 Anti-wrinkle Anti-inflamm1ation Collagen synthesis Inhibition of NO Moisturizing No.1 (% of control) production (%) HA synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF (10 ppb) 320% 56 Comparative 3.18 5.62 25.64 Example 56-1 15.87 20.04 356.83 20.92 30.49 412.62 32.77 39.74 772.97 56-2 13.74 24.42 328.98 25.94 29.40 583.96 30.62 38.45 674.76 56-3 12.57 21.91 331.05 27.51 31.72 545.46 31.17 25.08 604.62 56-4 13.76 23.35 258.94 23.44 33.96 560.31 31.11 34.68 717.89 56-5 17.70 23.70 327.70 28.79 33.41 449.69 30.96 37.80 784.95 56-6 13.41 23.30 302.66 29.21 32.15 479.57 39.24 36.54 658.20

TABLE-US-00107 TABLE 107 Sample Anti-oxidation No. Control group Scientific name English name IC50 (%) 56 Island corydalis Corydalis ilistipes Nakai Island corydalis Vitamin C 7.5 ppm Comparative Korean corydalis Corydalis Turtschaninovii 8.47 Example 56-1 Whole plant 0.97 56-2 Roots 0.44 56-3 Stems 0.38 56-4 Leaves 0.21 56-5 Fruits 0.91 56-6 Flowers 0.98 Anti-bacteria Anti-bacteria (S. mutans) (P .gingivalis) Anti-bacteria Size of growth Size of growth No. MIC (%) inhibition ring (mm) inhibition ring (mm) Hexanediol Untreated 0 mm Untreated 0 mm Bacteria: P.aeruginosa 2% Fungi: A.niger 1% 56 Comparative MIC (%) Bacteria, Fungi: >2 9.0 11.9 Example 56-1 MIC (%) Bacteria, Fungi: 1 25.9 27.1 56-2 MIC (%) Bacteria, Fungi: 0.25 13.4 18.6 56-3 MIC (%) Bacteria, Fungi: 1 22.5 22.5 56-4 MIC (%) Bacteria: 0.125 11.9 13.0 MIC (%)Fungi: 1 56-5 MIC (%) Bacteria: 0.25 14.4 15.0 MIC (%)Fungi: 1 56-6 MIC (%) Bacteria: 0.0625 22.6 20.1 MIC (%)Fungi: 0.125

EXAMPLE 57

Ulleungdo Raspberry

[0157]

TABLE-US-00108 TABLE 108 Conc. Whitening Melanin No. Sample (ppm) Scientific name English name content (%) Control group Arbutin (200 ppm) 57 Ulleungdo raspberry Rubus takesimensis Nakai Ulleungdo raspberry 88.26 Comparative Red raspberry 50 Rubus Idaeus Example 57-1 Whole plant 2 35.52 10 29.30 50 24.59 57-2 Roots 2 36.20 10 29.89 50 21.49 57-3 Stems 2 38.43 10 27.47 50 24.59 57-4 Leaves 2 34.68 10 30.08 50 26.54 57-5 Fruits 2 36.61 10 29.00 50 24.52 57-6 Flowers 2 34.33 10 32.63 50 26.10 Anti-wrinkle Anti-inflammation Collagen synthesis Inhibition of Moisturizing No. (% of control) NO production (%) HA synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF (10 ppb) 320% 57 Comparative 7.23 5.12 190.56 Example 57-1 18.45 21.88 212.06 20.35 31.14 599.34 35.92 37.45 799.77 57-2 15.02 25.11 269.16 20.18 30.97 533.24 32.12 38.29 618.28 57-3 19.94 21.47 325.60 28.81 29.09 593.48 37.81 35.85 749.63 57-4 10.77 25.35 332.91 23.47 29.94 534.11 30.48 39.26 755.38 57-5 18.20 24.11 305.69 28.90 30.69 402.85 34.50 34.28 650.34 57-6 10.21 26.64 302.50 26.70 32.16 432.22 34.64 39.21 600.75

TABLE-US-00109 TABLE 109 Anti-oxidation No. Sample Scientific name English name IC50 (%) Control group Vitamin C 7.5 ppm 57 Ulleungdo raspberry Rubus takesimensis Nakai Ulleungdo raspberry Comparative Red raspberry Rubus Idaeus 6.27 Example 57-1 Whole plant 0.56 57-2 Roots 0.19 57-3 Stems 0.76 57-4 Leaves 0.12 57-5 Fruits 0.67 57-6 Flowers 0.54 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Anti-bacteria Size of growth Size of growth No. MIC (%) inhibition ring (mm) inhibition ring (mm) Hexanediol Bacteria: Untreated 0 mm Untreated 0 mm P.aeruginosa 2% Fungi: A.niger 1% 57 Comparative MIC (%) Bacteria: 2, Fungi: >2 10.2 11.8 Example 57-1 MIC (%) Bacteria, Fungi: 0.125 24.5 27.2 57-2 MIC (%) Bacteria, Fungi: 0.5 15.9 14.6 57-3 MIC (%) Bacteria, Fungi: 1 25.7 20.1 57-4 MIC (%) Bacteria: 0.125 8.7 14.9 MIC (%)Fungi: 0.25 57-5 MIC (%) Bacteria: 0.25 21.4 10.9 MIC (%)Fungi: 0.5 57-6 MIC (%) Bacteria: 0.25 26.7 16.6 MIC (%)Fungi: 0.125

EXAMPLE 58

Korea Dystaenia

[0158]

TABLE-US-00110 TABLE 110 No. Sample Conc. (ppm) Scientific name English name Whitening Melanin content (%) Control group Arbutin (200 ppm) 35% 58 Korea Dystaenia Dystaenia takeshimana (Nakai) Kitag Korea Dystaenia 58-1 Whole plant 2 35.79 10 32.36 50 22.51 58-2 Roots 2 35.98 10 27.66 50 26.02 58-3 Stems 2 39.54 10 27.23 50 25.44 58-4 Leaves 2 34.93 10 33.42 50 28.82 58-5 Fruits 2 39.71 10 28.30 50 23.78 58-6 Flowers 2 38.83 10 33.66 50 21.78 Anti-wrinkle Anti-inflammation Collagen synthesis Inhibition of Moisturizing No. (% of control) NO production (%) HA synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF(10 ppb) 320% 58 58-1 16.06 21.05 275.71 23.15 29.41 498.69 35.58 38.15 664.44 58-2 10.72 21.58 351.33 20.10 31.30 500.37 30.30 33.63 679.52 58-3 15.38 20.69 279.07 20.58 29.96 541.11 32.18 32.74 764.16 58-4 17.47 24.88 363.53 27.98 28.56 526.76 31.77 33.08 731.21 58-5 15.34 23.59 241.39 21.95 32.68 462.67 36.43 37.84 727.07 58-6 15.88 23.60 267.02 23.59 31.40 469.70 34.97 37.17 758.76

TABLE-US-00111 TABLE 111 Anti-oxidation No. Sample Scientific name English name IC50 (%) Control group Vitamin C 7.5 ppm 58 Korea Dystaenia Dystaenia takeshimana (Nakai) Korea Dystaenia Kitag 58-1 Whole plant 0.43 58-2 Roots 0.55 58-3 Stems 0.87 58-4 Leaves 0.20 58-5 Fruits 0.89 58-6 Flowers 0.99 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth No. Anti-bacteria MIC (%) inhibition ring (mm) inhibition ring (mm) Hexanediol Untreated 0 mm Untreated 0 mm Bacteria: P.aeruginosa 2% 58 Fungi: A.niger 1% 58-1 MIC (%) Bacteria, Fungi: 1 24.1 21.3 58-2 MIC (%) Bacteria, Fungi: 2 10.9 14.5 58-3 MIC (%) Bacteria, Fungi: 1 9.2 14.2 58-4 MIC (%) Bacteria: 0.5 18.7 22.7 MIC (%)Fungi: 0.25 58-5 MIC (%) Bacteria: 0.5 10.2 20.4 MIC (%)Fungi: 0.5 58-6 MIC (%) Bacteria: 0.25 20.7 25.7 MIC (%)Fungi: 0.5

EXAMPLE 59

Ulleungdo Violet

[0159]

TABLE-US-00112 TABLE 112 Whitening Melanin No. Sample Conc. (ppm) Scientific name English name content (%) Control group Arbutin (200 ppm) 35% 59 Ulleungdo violet Viola takeshimana Nakai Ulleungdo violet Comparative Sweet violet 50 Viola Odorata 72.36 Example 59-1 Whole plant 2 36.20 10 27.81 50 20.44 59-2 Roots 2 35.90 10 27.60 50 20.85 59-3 Stems 2 38.00 10 29.56 50 23.42 59-4 Leaves 2 36.74 10 29.59 50 23.06 59-5 Fruits 2 37.12 10 32.95 50 23.64 59-6 Flowers 2 36.73 10 29.50 50 23.17 Anti-wrinkle Anti-inflammation Collagen synthesis Inhibition of NO Moisturizing No. (% of control) production (%) HA synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF (10 ppb) 320% 59 Comparative 3.74 1.27 120.35 Example 59-1 18.78 20.81 238.64 22.90 29.75 466.01 34.29 37.07 645.23 59-2 12.12 24.70 252.05 22.60 31.00 515.36 30.47 39.79 705.18 59-3 19.02 24.47 277.01 20.95 27.13 575.38 33.36 37.89 658.51 59-4 17.43 24.13 363.57 21.49 31.24 562.86 33.71 38.37 758.61 59-5 17.33 25.50 231.00 29.72 28.22 463.26 38.03 37.08 611.11 59-6 17.77 26.96 398.74 24.68 33.30 410.85 30.30 38.10 675.69

TABLE-US-00113 TABLE 113 Anti-oxidation No. Sample Scientific name English name IC50 (%) Control group Vitamin C 7.5 ppm 59 Ulleungdo violet Viola takeshimana Nakai Ulleungdo violet Comparative Sweet violet Viola Odorata 9.21 Example 59-1 Whole plant 0.25 59-2 Roots 0.84 59-3 Stems 0.87 59-4 Leaves 0.51 59-5 Fruits 0.49 59-6 Flowers 0.21 Anti-bacteria Anti-bacteria (S. mutans) (P. gingivalis) Size of growth Size of growth No. Anti-bacteria MIC (%) inhibition ring (mm) inhibition ring (mm) Hexanediol Untreated 0 mm Untreated 0 mm Bacteria: P.aeruginosa 2% Fungi: A.niger 1% 59 Comparative MIC (%) Bacteria, Fungi: 2 17.5 19.8 Example 59-1 MIC (%) Bacteria, Fungi: 1 21.0 23.7 59-2 MIC (%) Bacteria, Fungi: 2 20.2 18.4 59-3 MIC (%) Bacteria, Fungi: 1 25.3 20.4 59-4 MIC (%) Bacteria: 0.125 14.6 11.7 MIC (%)Fungi: 0.25 59-5 MIC (%) Bacteria: 0.25 20.2 10.1 MIC (%)Fungi: 0.5 59-6 MIC (%) Bacteria: 0.25 12.7 9.0 MIC (%)Fungi: 0.125

EXAMPLE 60

Spindle Tree

[0160]

TABLE-US-00114 TABLE 114 Whitening Melanin No. Sample Conc. (ppm) Scientific name English name content (%) Control group Arbutin (200 ppm) 35% 60 Spindle Tree Euonymus japonicus Thunb. Spindle Tree Comparative Korean spindle tree 50 Euonymus sachalinensis 82.34 Example 60-1 Whole plant 2 39.32 10 29.75 50 22.60 60-2 Roots 2 36.51 10 30.47 50 22.95 60-3 Stems 2 37.09 10 29.16 50 20.86 60-4 Leaves 2 35.66 10 31.48 50 24.43 60-5 Fruits 2 37.26 10 29.84 50 25.04 60-6 Flowers 2 34.37 10 27.81 50 20.01 Anti-wrinkle Anti-inflammation Collagen synthesis Inhibition of Moisturizing HA No. (% of control) NO production (%) synthesis (%) TGFb (10 ppb) 25% L-NMMA (5 ppm) 28% EGF (10 ppb) 320% 60 Comparative 1.12 2.54 56.34 Example 60-1 16.61 23.11 380.72 20.02 27.40 505.95 34.72 36.75 604.95 60-2 11.00 26.36 392.74 29.61 29.51 600.41 34.27 35.80 730.26 60-3 19.05 23.14 202.93 20.25 27.84 414.03 37.18 37.54 648.42 60-4 16.85 24.69 282.19 29.43 27.19 453.32 38.83 37.66 642.30 60-5 11.81 23.89 208.93 22.01 28.10 533.39 31.57 38.76 629.87 60-6 13.44 23.24 325.66 20.40 29.56 483.29 30.11 38.91 793.18

TABLE-US-00115 TABLE 115 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 60 Spindle Tree Euonymus japonicus Spindle Tree Thunb. Comparative Korean Euonymus 2.98 MIC (%) Bacteria: 1 9.7 9.1 Example spindle tree sachalinensis MIC (%) Fungi: 1 60-1 Whole plant 0.13 MIC (%) Bacteria: 0.0625 18.2 20.2 MIC (%) Fungi: 0.0625 60-2 Roots 0.43 MIC (%) Bacteria: 0.125 10.5 12.1 MIC (%) Fungi: 0.125 60-3 Stems 0.50 MIC (%) Bacteria: 0.5 11.9 13.1 MIC (%) Fungi: 0.5 60-4 Leaves 0.75 MIC (%) Bacteria: 0.5 25.8 20.8 MIC (%) Fungi: 0.5 60-5 Fruits 0.81 MIC (%) Bacteria: 0.5 11.0 10.8 MIC (%) Fungi: 0.5 60-6 Flowers 0.40 MIC (%) Bacteria: 0.5 26.8 19.8 MIC (%) Fungi: 0.5

EXAMPLE 61

Crimson Grapevine

[0161]

TABLE-US-00116 TABLE 116 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 61 Crimson Vitis coignetiae Crimson grapevine Pulliat ex Planch. grapevine Comparative Grape 50 Vitis Vinifera 95.32 3.34 2.56 76.43 Example (Grape) Fruit Water Comparative Crimson 50 57.82 15.36 14.45 165.33 Example grapevine (other area) 61-1 Whole plant 2 32.22 15.88 25.98 408.55 10 25.14 20.19 41.07 683.78 50 14.44 42.33 55.90 849.00 61-2 Roots 2 32.08 18.83 21.04 344.14 10 23.78 25.79 28.65 415.52 50 35.87 30.71 35.03 682.84 61-3 Stems 2 32.50 12.01 22.60 291.68 10 23.71 23.88 27.88 574.32 50 39.42 36.04 34.97 750.46 61-4 Leaves 2 30.02 15.03 23.12 248.58 10 21.78 28.06 27.60 495.36 50 37.37 30.68 38.63 613.55 61-5 Fruits 2 31.99 14.81 24.60 221.57 10 24.21 27.48 31.27 400.96 50 34.37 38.59 38.41 760.87 61-6 Flowers 2 27.81 13.44 25.49 331.35 10 20.01 20.40 28.11 454.63 50 30.11 35.49 794.05

TABLE-US-00117 TABLE 117 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 61 Crimson Vitis coignetiae Crimson grapevine Pulliat ex Planch. grapevine Comparative Grape Vitis Vinifera 2.98 MIC (%) Bacteria: >2 0.0 0.0 Example (Grape) Fruit Water MIC (%) Fungi: >2 Comparative Crimson grapevine 3.77 MIC (%) Bacteria: 2 8.2 9.4 Example (other area) MIC (%) Fungi: 1 61-1 Whole plant 0.65 MIC (%) Bacteria: 0.125 17.3 16.4 MIC (%) Fungi: 0.125 61-2 Roots 0.30 MIC (%) Bacteria: 0.5 13.4 17.6 MIC (%) Fungi: 0.5 61-3 Stems 0.74 MIC (%) Bacteria: 0.125 23.4 21.0 MIC (%) Fungi: 0.125 61-4 Leaves 0.59 MIC (%) Bacteria: 0.5 17.2 17.3 MIC (%) Fungi: 0.5 61-5 Fruits 0.41 MIC (%) Bacteria: 0.5 11.8 16.0 MIC (%) Fungi: 0.5 61-6 Flowers 0.28 MIC (%) Bacteria: 0.0625 17.1 21.7 MIC (%) Fungi: 0.0625

EXAMPLE 62

Aralia Continentalis

[0162]

TABLE-US-00118 TABLE 118 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 62 Aralia Aralia cordata Aralia continentalis var. continentalis continentalis (Kitag.) Y. C. Chu Comparative American 50 Aralia Racemosa 89.23 5.23 5.34 66.87 Example spikenard Comparative Aralia 50 66.58 12.61 12.60 105.41 Example continentalis (other area) 62-1 Whole plant 2 39.28 14.41 25.98 317.84 10 31.42 26.00 31.07 507.23 50 23.10 38.66 35.90 626.10 62-2 Roots 2 37.60 19.53 21.04 214.14 10 28.26 24.36 28.65 590.21 50 23.13 36.31 35.03 608.17 62-3 Stems 2 36.58 11.61 22.60 245.41 10 31.58 29.45 27.88 452.94 50 26.32 35.33 34.97 761.80 62-4 Leaves 2 37.43 14.78 23.12 394.75 10 28.61 20.46 27.60 426.68 50 21.28 30.12 38.63 650.68 62-5 Fruits 2 39.19 17.14 24.60 259.10 10 28.96 20.59 31.27 492.63 50 24.77 32.77 38.41 625.32 62-6 Flowers 2 34.37 13.44 20.43 276.09 10 27.81 20.40 32.34 455.01 50 20.01 30.11 35.96 627.68

TABLE-US-00119 TABLE 119 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 62 Aralia Aralia cordata Aralia continentalis var. continentalis continentalis (Kitag.) Y. C. Chu Comparative American Aralia Racemosa 3.23 MIC (%) Bacteria: 2 9.6 9.6 Example spikenard MIC (%) Fungi: >2 Comparative Aralia 3.42 MIC (%) Bacteria: 1 10.2 11.5 Example continentalis (other area) MIC (%) Fungi: 2 62-1 Whole plant 0.45 MIC (%) Bacteria: 0.5 19.3 24.9 MIC (%) Fungi: 0.5 62-2 Roots 0.46 MIC (%) Bacteria: 0.5 8.5 8.2 MIC (%) Fungi: 0.5 62-3 Stems 0.11 MIC (%) Bacteria: 0.5 11.9 13.6 MIC (%) Fungi: 0.5 62-4 Leaves 0.79 MIC (%) Bacteria: 0.5 25.4 24.2 MIC (%) Fungi: 0.5 62-5 Fruits 0.46 MIC (%) Bacteria: 0.0625 11.5 9.9 MIC (%) Fungi: 0.0625 62-6 Flowers 0.13 MIC (%) Bacteria: 0.5 18.8 8.7 MIC (%) Fungi: 0.5

EXAMPLE 63

Japanese Angelica

[0163]

TABLE-US-00120 TABLE 120 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 Ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 63 Japanese Aralia elata Japanese Angelica (Miq.) Seem. Angelica Comparative American 50 Aralia Racemosa 89.23 5.23 5.34 66.87 Example spikenard Comparative Japanese 50 76.58 16.85 11.60 244.41 Example Angelica (other area) 63-1 Whole plant 2 39.81 19.60 23.91 296.54 10 33.97 22.11 32.00 454.69 50 26.10 37.22 37.55 769.13 63-2 Roots 2 34.90 13.86 20.55 290.93 10 32.78 24.54 32.39 455.13 50 25.51 31.82 34.95 779.22 63-3 Stems 2 36.66 18.28 21.70 205.08 10 30.99 29.99 30.41 465.64 50 20.28 34.15 37.03 635.56 63-4 Leaves 2 38.92 12.68 24.53 255.20 10 29.01 26.37 33.64 544.83 50 20.79 38.33 34.47 610.78 63-5 Fruits 2 37.27 16.63 25.55 361.49 10 33.82 28.20 32.69 519.50 50 24.26 39.00 39.16 602.39 63-6 Flowers 2 34.37 13.44 25.97 296.88 10 27.81 20.40 29.67 516.40 50 20.01 30.11 39.88 750.27 63-7 Shoots 2 39.07 15.89 22.17 352.19 10 33.76 22.69 28.37 549.85 50 22.00 35.56 38.97 666.01

TABLE-US-00121 TABLE 121 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 63 Japanese Aralia elata Japanese Angelica (Miq.) Seem. Angelica Comparative American Aralia Racemosa 3.23 MIC (%) Bacteria: 2 8.0 9.9 Example spikenard MIC (%) Fungi: >2 Comparative Japanese 2.31 MIC (%) Bacteria: 1 8.8 9.7 Example Angelica (other area) MIC (%) Fungi: 1 63-1 Whole plant 0.89 MIC (%) Bacteria: 0.125 17.9 19.3 MIC (%) Fungi: 0.125 63-2 Roots 0.73 MIC (%) Bacteria: 0.5 16.4 19.0 MIC (%) Fungi: 0.5 63-3 Stems 0.39 MIC (%) Bacteria: 0.5 22.3 23.7 MIC (%) Fungi: 0.5 63-4 Leaves 0.67 MIC (%) Bacteria: 0.5 12.5 14.0 MIC (%) Fungi: 0.5 63-5 Fruits 0.52 MIC (%) Bacteria: 0.0625 22.6 21.6 MIC (%) Fungi: 0.0625 63-6 Flowers 0.65 MIC (%) Bacteria: 0.125 15.7 11.7 MIC (%) Fungi: 0.125 63-7 Shoots 0.75 MIC (%) Bacteria: 0.25 11.4 8.5 MIC (%) Fungi: 0.125

EXAMPLE 64

Glossy-Leaf Paper Plant

[0164]

TABLE-US-00122 TABLE 122 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 64 Glossy-leaf Fatsia japonica Glossy-leaf paper plant (Thunb.) Decne. & paper plant Planch. Comparative Glossy-leaf 50 86.58 2.42 11.60 114.41 Example paper plant (other area) 64-1 Whole plant 2 37.45 18.61 20.13 245.46 10 32.44 24.19 28.16 540.61 50 24.25 36.65 35.63 666.75 64-2 Roots 2 38.41 15.81 23.24 279.07 10 28.06 27.97 28.95 495.20 50 20.21 30.82 36.33 723.24 64-3 Stems 2 36.77 12.06 20.47 348.86 10 31.45 22.99 33.78 408.25 50 26.52 34.91 34.35 636.95 64-4 Leaves 2 37.25 16.73 24.24 225.89 10 32.73 27.21 28.14 458.51 50 26.18 32.93 38.26 642.56 64-5 Fruits 2 34.35 19.97 25.27 253.57 10 28.91 24.20 33.72 469.64 50 26.77 34.82 38.94 686.57 64-6 Flowers 2 34.37 13.44 25.79 292.97 10 27.81 20.40 32.55 469.32 50 20.01 30.11 36.38 708.80

TABLE-US-00123 TABLE 123 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 64 Glossy-leaf Fatsia japonica Glossy-leaf paper plant (Thunb.) Decne. & paper plant Planch. Comparative Glossy-leaf 1.56 MIC (%) Bacteria: 2 10.4 8.5 Example paper plant (other area) MIC (%) Fungi: 1 64-1 Whole plant 0.71 MIC (%) Bacteria: 0.125 22.0 25.8 MIC (%) Fungi: 0.125 64-2 Roots 0.38 MIC (%) Bacteria: 0.125 18.4 14.7 MIC (%) Fungi: 0.125 64-3 Stems 0.76 MIC (%) Bacteria: 0.0625 18.4 16.0 MIC (%) Fungi: 0.0625 64-4 Leaves 0.72 MIC (%) Bacteria: 0.5 24.0 23.0 MIC (%) Fungi: 0.5 64-5 Fruits 0.87 MIC (%) Bacteria: 0.5 11.9 12.0 MIC (%) Fungi: 0.5 64-6 Flowers 0.23 MIC (%) Bacteria: 0.5 10.0 15.7 MIC (%) Fungi: 0.5

EXAMPLE 65

Three-Leaf Clematis

[0165]

TABLE-US-00124 TABLE 124 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 65 Three-leaf Clematis apiifolia Three-leaf clematis DC. clematis Comparative Clematis 50 Clematis Vitalba 85.54 10.47 2.38 65.47 Example 65-1 Whole plant 2 37.52 13.96 24.37 259.29 10 28.36 23.80 30.85 517.54 50 25.35 39.09 39.71 610.96 65-2 Roots 2 37.84 14.46 22.23 346.50 10 29.96 21.33 27.40 481.97 50 26.52 33.97 34.78 666.78 65-3 Stems 2 37.03 12.60 24.12 247.92 10 33.98 23.25 32.15 524.23 50 26.87 35.49 36.74 605.86 65-4 Leaves 2 34.16 13.84 22.63 233.90 10 31.93 20.54 32.12 411.84 50 21.90 39.60 35.02 612.26 65-5 Fruits 2 37.95 11.39 26.47 302.07 10 31.47 20.52 32.26 574.17 50 23.59 33.71 36.38 710.86 65-6 Flowers 2 36.25 16.47 26.71 386.59 10 32.25 29.84 28.47 557.17 50 25.58 35.29 35.98 734.71

TABLE-US-00125 TABLE 125 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 65 Three-leaf Clematis apiifolia Three-leaf clematis DC. clematis Comparative Clematis Clematis Vitalba 7.48 MIC (%) Bacteria, 9.2 8.8 Example Fungi: >2 65-1 Whole plant 0.07 MIC (%) Bacteria: 0.25 21.6 24.6 MIC (%) Fungi: 0.25 65-2 Roots 0.26 MIC (%) Bacteria: 0.125 21.6 11.4 MIC (%) Fungi: 0.25 65-3 Stems 0.17 MIC (%) Bacteria: 0.25 14.9 15.8 MIC (%) Fungi: 0.125 65-4 Leaves 0.08 MIC (%) Bacteria: 0.0625 21.3 9.7 MIC (%) Fungi: 0.125 65-5 Fruits 0.13 MIC (%) Bacteria: 0.125 26.2 14.0 MIC (%) Fungi: 0.125 65-6 Flowers 0.05 MIC (%) Bacteria: 0.0625 17.1 15.9 MIC (%) Fungi: 0.0625

EXAMPLE 66

Lyre-Leaf Nightshade

[0166]

TABLE-US-00126 TABLE 126 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 66 Lyre-leaf Solanum lyratum Lyre-leaf nightshade Thunb. nightshade Comparative Tomato 50 Solanum 93.21 7.28 2.14 84.19 Example Lycopersicum 66-1 Whole plant 2 36.68 16.83 20.25 239.79 10 32.11 27.46 30.93 423.49 50 23.19 37.75 35.93 777.92 66-2 Roots 2 36.65 15.33 20.40 314.55 10 28.42 28.98 28.38 598.91 50 23.93 31.59 39.09 750.34 66-3 Stems 2 34.70 19.09 26.61 245.91 10 31.98 23.39 33.86 458.53 50 22.20 31.38 34.41 685.22 66-4 Leaves 2 38.13 11.21 22.50 284.06 10 32.90 27.05 29.51 519.30 50 24.98 38.60 39.10 753.34 66-5 Fruits 2 34.68 17.96 24.33 400.53 10 27.49 23.68 31.23 443.47 50 24.80 34.55 37.69 606.11 66-6 Flowers 2 34.98 11.31 21.80 341.11 10 28.55 27.01 29.28 576.44 50 25.17 33.24 36.70 794.68

TABLE-US-00127 TABLE 127 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 66 Lyre-leaf Solanum lyratum Lyre-leaf nightshade Thunb. nightshade Comparative Tomato Solanum 3.29 MIC (%) Bacteria, 0.0 0.0 Example Lycopersicum Fungi: >2 66-1 Whole plant 0.11 MIC (%) Bacteria: 0.125 20.5 15.6 MIC (%) Fungi: 0.125 66-2 Roots 0.13 MIC (%) Bacteria: 0.125 10.0 14.1 MIC (%) Fungi: 0.25 66-3 Stems 0.17 MIC (%) Bacteria: 0.25 16.1 22.1 MIC (%) Fungi: 0.25 66-4 Leaves 0.09 MIC (%) Bacteria: 0.0625 26.4 14.3 MIC (%) Fungi: 0.125 66-5 Fruits 0.14 MIC (%) Bacteria: 0.125 23.5 25.7 MIC (%) Fungi: 0.125 66-6 Flowers 0.07 MIC (%) Bacteria: 0.0625 12.7 20.8 MIC (%) Fungi: 0.0625

EXAMPLE 67

Ivy Morning Glory

[0167]

TABLE-US-00128 TABLE 128 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 67 Ivy Calystegia hederacea Ivy morning glory Wall. morning glory Comparative Convolvulus 50 Calystegia Sepium 85.14 15.56 5.33 64.52 Example 67-1 Whole plant 2 38.64 16.33 25.11 235.21 10 32.30 24.08 32.94 406.90 50 21.02 36.03 38.04 627.45 67-2 Roots 2 34.06 10.35 23.95 329.07 10 33.40 24.23 32.64 583.00 50 21.07 31.04 39.75 714.13 67-3 Stems 2 35.55 18.48 25.12 349.26 10 28.21 28.01 32.23 405.88 50 24.42 30.25 39.96 669.08 67-4 Leaves 2 39.22 15.54 21.55 348.95 10 32.63 25.59 32.70 526.26 50 23.85 39.02 37.20 650.78 67-5 Fruits 2 35.41 15.59 20.04 300.06 10 32.56 28.31 32.67 416.83 50 26.07 32.69 36.37 794.47 67-6 Flowers 2 36.27 19.81 23.38 276.47 10 28.45 20.56 31.48 586.01 50 20.28 36.45 37.17 662.34 67-7 Shoots 2 36.98 12.58 23.24 242.25 10 30.33 22.60 31.52 589.80 50 23.23 31.32 37.31 695.08 67-8 Underground 2 36.20 11.17 25.75 355.04 stems 10 31.55 22.27 31.74 536.31 50 26.13 33.26 37.62 705.69

TABLE-US-00129 TABLE 129 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 67 Ivy Calystegia hederacea Ivy morning glory Wall. morning glory Comparative Convolvulus Calystegia Sepium 7.69 MIC (%) Bacteria: 1, 8.1 11.1 Example Fungi: 1 67-1 Whole plant 0.25 MIC (%) Bacteria: 0.5 26.1 27.4 MIC (%) Fungi: 0.25 67-2 Roots 0.27 MIC (%) Bacteria: 0.125 18.5 20.7 MIC (%) Fungi: 0.125 67-3 Stems 0.32 MIC (%) Bacteria: 0.5 12.7 24.7 MIC (%) Fungi: 0.25 67-4 Leaves 0.24 MIC (%) Bacteria: 0.25 14.3 25.6 MIC (%) Fungi: 0.25 67-5 Fruits 0.19 MIC (%) Bacteria: 0.125 22.0 15.7 MIC (%) Fungi: 0.125 67-6 Flowers 0.26 MIC (%) Bacteria: 0.125 21.5 17.3 MIC (%) Fungi: 0.125 67-7 Shoots 0.27 MIC (%) Bacteria: 0.5 21.0 20.5 MIC (%) Fungi: 0.5 67-8 Underground 0.89 MIC (%) Bacteria: 0.25 9.0 22.9 stems MIC (%) Fungi: 0.5

EXAMPLE 68

Beach Morning Glory

[0168]

TABLE-US-00130 TABLE 130 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 68 Beach Calystegia soldanella Beach morning glory (L.) Roem & Schult. morning glory Comparative Convolvulus 50 Calystegia Sepium 85.14 15.56 5.33 64.52 Example 68-1 Whole plant 2 38.02 17.78 25.89 276.45 10 31.51 26.14 33.55 429.08 50 23.85 32.15 37.39 746.07 68-2 Roots 2 39.44 11.12 22.08 231.29 10 28.06 29.12 33.41 581.52 50 24.66 31.50 34.77 760.42 68-3 Stems 2 37.85 16.50 22.92 399.08 10 31.67 24.51 30.99 578.28 50 21.36 32.89 38.80 708.35 68-4 Leaves 2 37.60 10.55 25.30 321.80 10 28.42 27.50 31.05 592.86 50 26.17 35.64 36.35 645.27 68-5 Fruits 2 34.78 17.61 21.45 389.10 10 27.14 28.27 32.01 401.26 50 21.73 32.35 39.56 606.85 68-6 Flowers 2 39.99 11.60 24.37 396.05 10 30.69 28.93 28.78 553.19 50 26.96 35.80 37.03 692.82 68-7 Shoots 2 37.02 17.85 24.52 267.00 10 33.34 27.70 33.75 541.63 50 22.71 31.02 34.83 793.25 68-8 Underground 2 38.57 14.04 23.21 244.39 stems 10 32.36 28.32 31.65 589.79 50 23.13 31.38 36.58 786.22

TABLE-US-00131 TABLE 131 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 68 Beach Calystegia soldanella Beach morning glory (L.) Roem. & Schult. morning glory Comparative Convolvulus Calystegia Sepium 7.69 MIC (%) Bacteria: 1, 8.9 9.4 Example Fungi: 1 68-1 Whole plant 0.14 MIC (%) Bacteria: 0.125 19.8 16.4 MIC (%) Fungi: 0.25 68-2 Roots 0.29 MIC (%) Bacteria: 0.25 26.3 14.1 MIC (%) Fungi: 0.25 68-3 Stems 0.16 MIC (%) Bacteria: 0.125 17.6 13.2 MIC (%) Fungi: 0.125 68-4 Leaves 0.21 MIC (%) Bacteria: 0.25 22.0 9.8 MIC (%) Fungi: 0.125 68-5 Fruits 0.09 MIC (%) Bacteria: 0.0625 14.9 10.2 MIC (%) Fungi: 0.0625 68-6 Flowers 0.07 MIC (%) Bacteria: 0.0625 16.3 26.6 MIC (%) Fungi: 0.0625 68-7 Shoots 0.21 MIC (%) Bacteria: 0.5 21.5 12.3 MIC (%) Fungi: 0.25 68-8 Underground 0.85 MIC (%) Bacteria: 0.5 15.4 10.7 stems MIC (%) Fungi: 0.5

EXAMPLE 69

East Asian Beautyberry

[0169]

TABLE-US-00132 TABLE 132 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 69 East Asian Callicarpa japonica East Asian beautyberry Thunb. beautyberry Comparative Purple 50 Callicarpa Dichotoma 74.64 15.12 2.41 54.26 Example beautyberry 69-1 Whole plant 2 39.15 15.22 26.94 400.97 10 31.26 20.91 28.04 577.41 50 21.32 36.26 36.46 695.41 69-2 Roots 2 38.49 17.26 21.19 209.06 10 27.03 28.92 30.16 480.34 50 24.94 36.82 39.89 672.78 69-3 Stems 2 35.78 11.06 21.65 273.62 10 27.98 27.69 31.54 451.81 50 21.62 36.69 35.57 742.09 69-4 Leaves 2 36.83 12.80 20.45 275.43 10 27.38 27.16 25.17 498.65 50 26.57 30.10 30.51 661.64 69-5 Fruits 2 34.78 12.00 20.71 244.98 10 29.89 21.03 32.88 466.34 50 20.89 32.39 39.78 775.51 69-6 Flowers 2 34.53 12.54 24.08 356.14 10 29.80 29.54 27.48 559.12 50 21.53 36.73 37.04 727.81

TABLE-US-00133 TABLE 133 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 69 East Asian Callicarpa japonica East Asian beautyberry Thunb. beautyberry Comparative Purple Callicarpa Dichotoma 3.22 MIC (%) Bacteria: 1, 11.5 11.0 Example beautyberry Fungi: 2 69-1 Whole plant 0.14 MIC (%) Bacteria: 0.5 25.5 20.6 MIC (%) Fungi: 0.5 69-2 Roots 0.19 MIC (%) Bacteria: 0.25 17.3 14.5 MIC (%) Fungi: 0.25 69-3 Stems 0.15 MIC (%) Bacteria: 0.125 13.6 12.6 MIC (%) Fungi: 0.25 69-4 Leaves 0.21 MIC (%) Bacteria: 0.25 11.5 12.6 MIC (%) Fungi: 0.25 69-5 Fruits 0.08 MIC (%) Bacteria: 0.0625 25.3 25.8 MIC (%) Fungi: 0.0625 69-6 Flowers 0.04 MIC (%) Bacteria: 0.0625 9.1 19.4 MIC (%) Fungi: 0.0625

EXAMPLE 70

Korean Mint

[0170]

TABLE-US-00134 TABLE 134 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 70 Korean mint Agastache rugosa Korean mint (Fisch. & C. A. Mev) Kuntze Comparative Anise hyssop 50 Agastache Foeniculum 93.66 8.54 3.15 32.80 Example 70-1 Whole plant 2 37.70 12.32 20.50 348.18 10 29.90 29.00 33.30 473.40 50 25.29 37.87 34.03 719.57 70-2 Roots 2 37.78 10.19 26.81 281.13 10 30.20 29.57 31.81 411.91 50 21.84 39.06 39.55 788.31 70-3 Stems 2 37.46 19.38 24.92 368.86 10 29.99 25.20 33.96 549.40 50 24.99 30.60 35.82 763.35 70-4 Leaves 2 36.23 17.25 24.54 218.66 10 30.26 29.65 30.89 542.20 50 25.01 31.94 34.40 754.76 70-5 Fruits 2 35.27 13.94 26.74 272.11 10 30.59 28.81 29.95 405.97 50 26.97 33.09 36.94 693.34 70-6 Flowers 2 36.66 19.88 21.38 261.56 10 29.81 26.47 28.47 418.52 50 25.43 35.27 36.54 622.59

TABLE-US-00135 TABLE 135 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 70 Korean mint Agastache rugosa Korean mint (Fisch. & C. A. Mev) Kuntze Comparative Anise hyssop Agastache Foeniculum 6.34 MIC (%) Bacteria: 2 9.6 8.4 Example MIC (%) Fungi: 2 70-1 Whole plant 0.31 MIC (%) Bacteria: 0.25 15.5 16.8 MIC (%) Fungi: 0.25 70-2 Roots 0.90 MIC (%) Bacteria: 0.25 14.9 16.1 MIC (%) Fungi: 0.125 70-3 Stems 0.85 MIC (%) Bacteria: 0.5 13.4 10.8 MIC (%) Fungi: 0.5 70-4 Leaves 0.72 MIC (%) Bacteria: 0.5 10.4 11.3 MIC (%) Fungi: 1 70-5 Fruits 0.59 MIC (%) Bacteria: 0.25 12.5 12.2 MIC (%) Fungi: 0.5 70-6 Flowers 0.35 MIC (%) Bacteria: 0.5 27.1 24.6 MIC (%) Fungi: 0.5

EXAMPLE 71

Small-Flower Asian Calamint

[0171]

TABLE-US-00136 TABLE 136 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 71 Small-flower Clinopodium chinense Small-flower Asian calamint var. parviflorum Asian calamint (Kudo) H. Hara 71-1 Whole plant 2 39.05 19.09 25.67 212.59 10 27.46 21.25 31.95 405.11 50 25.13 34.77 35.04 691.93 71-2 Roots 2 38.04 16.00 22.54 221.35 10 32.20 25.27 30.65 403.43 50 20.89 36.83 34.01 779.37 71-3 Stems 2 36.15 13.73 26.33 260.07 10 29.72 21.66 32.13 541.45 50 26.33 32.25 35.65 776.96 71-4 Leaves 2 34.47 15.37 26.86 342.94 10 28.65 28.42 33.18 507.66 50 23.97 33.54 34.53 691.76 71-5 Fruits 2 36.79 16.97 26.91 271.18 10 31.14 20.86 31.09 549.19 50 25.16 34.43 35.50 647.63 71-6 Flowers 2 34.71 17.31 21.22 220.91 10 31.93 26.59 29.99 497.80 50 25.02 31.59 38.60 634.77

TABLE-US-00137 TABLE 137 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 71 Small-flower Clinopodium chinense Small-flower Asian calamint var. parviflorum Asian calamint (Kudo) H. Hara 71-1 Whole plant 0.65 MIC (%) Bacteria: 1 25.3 23.2 MIC (%) Fungi: 1 71-2 Roots 0.79 MIC (%) Bacteria: 1 8.3 23.0 MIC (%) Fungi: 0.5 71-3 Stems 0.23 MIC (%) Bacteria: 0.25 20.9 13.0 MIC (%) Fungi: 0.5 71-4 Leaves 0.70 MIC (%) Bacteria: 1 19.9 27.3 MIC (%) Fungi: 0.5 71-5 Fruits 0.60 MIC (%) Bacteria: 0.5 8.5 9.8 MIC (%) Fungi: 0.25 71-6 Flowers 0.16 MIC (%) Bacteria: 0.25 13.4 23.3 MIC (%) Fungi: 0.125

EXAMPLE 72

Henbit Deadnettle

[0172]

TABLE-US-00138 TABLE 138 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Cone, content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 72 Henbit Lamium amplexicaule Henbit deadnettle L. deadnettle Comparative Deadnettle 50 Lamium Album 95.57 11.23 4.43 31.32 Example 72-1 Whole plant 2 39.53 12.69 15.50 278.63 10 28.06 29.35 21.55 517.60 50 24.19 32.10 30.14 734.73 72-2 Roots 2 35.97 12.89 11.93 299.85 10 32.27 26.50 25.34 577.49 50 21.49 38.06 37.34 734.88 72-3 Stems 2 36.30 17.87 19.63 262.37 10 32.30 23.96 24.25 543.84 50 25.60 35.49 39.23 611.56 72-4 Leaves 2 36.90 10.45 10.39 238.11 10 31.07 27.41 25.75 475.57 50 26.92 31.72 36.24 776.24 72-5 Fruits 2 37.88 15.96 11.79 309.45 10 28.68 21.05 24.78 478.81 50 23.60 34.57 36.22 764.62 72-6 Flowers 2 38.78 14.63 16.55 382.92 10 31.88 25.75 27.35 514.77 50 26.62 30.18 36.64 778.50

TABLE-US-00139 TABLE 139 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 72 Henbit Lamium amplexicaule Henbit deadnettle L. deadnettle Comparative Deadnettle Lamium Album 5.56 MIC (%) Bacteria: 0.5 8.5 8.1 Example MIC (%) Fungi: 1 72-1 Whole plant 0.58 MIC (%) Bacteria: 0.5 17.3 15.0 MIC (%) Fungi: 1 72-2 Roots 0.82 MIC (%) Bacteria: 0.5 17.6 9.0 MIC (%) Fungi: 0.5 72-3 Stems 0.81 MIC (%) Bacteria: 0.25 13.0 16.0 MIC (%) Fungi: 0.5 72-4 Leaves 0.43 MIC (%) Bacteria: 0.125 26.7 21.4 MIC (%) Fungi: 0.125 72-5 Fruits 0.79 MIC (%) Bacteria: 0.25 25.6 22.5 MIC (%) Fungi: 0.125 72-6 Flowers 0.92 MIC (%) Bacteria: 0.25 24.2 23.3 MIC (%) Fungi: 0.5

EXAMPLE 73

Oriental Motherwort

[0173]

TABLE-US-00140 TABLE 140 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 73 Oriental Leonurus japonicus Oriental motherwort Houtt. motherwort Comparative Leonurus cardiaca 50 Leonurus Cardiaca motherwort 77.38 11.28 2.17 98.89 Example 73-1 Whole plant 2 38.56 13.52 22.63 270.14 10 30.27 26.46 30.90 460.52 50 21.34 31.55 39.50 672.99 73-2 Roots 2 37.08 12.90 23.40 306.15 10 32.84 21.09 31.02 509.48 50 26.79 38.51 34.98 721.68 73-3 Stems 2 38.83 11.63 22.59 250.02 10 27.96 28.21 32.41 408.30 50 20.10 34.73 36.43 794.16 73-4 Leaves 2 34.19 16.99 21.10 367.30 10 28.67 29.49 28.95 436.15 50 20.15 36.68 35.28 653.08 73-5 Fruits 2 37.41 12.48 25.19 305.01 10 28.36 27.03 32.82 512.05 50 25.09 31.77 36.93 632.87 73-6 Flowers 2 34.89 19.74 23.81 285.12 10 29.61 29.34 27.81 576.37 50 20.20 37.44 34.72 795.79

TABLE-US-00141 TABLE 141 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 73 Oriental Leonurus japonicus Oriental motherwort Houtt. motherwort Comparative Leonurus cardiaca Leonurus Cardiaca motherwort 4.90 MIC (%) Bacteria: 2 8.6 12.6 Example MIC (%) Fungi: 2 73-1 Whole plant 0.35 MIC (%) Bacteria: 1 26.2 22.3 MIC (%) Fungi: 0.5 73-2 Roots 0.49 MIC (%) Bacteria: 0.5 26.5 20.8 MIC (%) Fungi: 0.25 73-3 Stems 0.64 MIC (%) Bacteria: 0.25 10.0 11.0 MIC (%) Fungi: 0.5 73-4 Leaves 0.88 MIC (%) Bacteria: 0.5 24.5 15.5 MIC (%) Fungi: 0.5 73-5 Fruits 0.21 MIC (%) Bacteria: 0.125 11.7 19.1 MIC (%) Fungi: 0.25 73-6 Flowers 0.19 MIC (%) Bacteria: 0.0625 18.3 17.0 MIC (%) Fungi: 0.0625

EXAMPLE 74

Long-Stalk Low Meadow-Rue

[0174]

TABLE-US-00142 TABLE 142 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 74 Long-stalk low Thalictrum kemense Long-stalk low meadow-rue Fr. meadow-rue Comparative Columbine 50 Thalictrum 78.25 1.82 2.71 56.01 Example meadow rue aquilegiifolium 74-1 Whole plant 2 39.94 12.01 23.53 361.89 10 32.57 27.73 32.27 476.94 50 22.49 33.51 35.39 732.35 74-2 Roots 2 34.83 16.83 24.21 285.43 10 27.15 20.55 32.11 573.31 50 21.28 31.86 35.82 767.85 74-3 Stems 2 38.94 12.99 23.32 212.01 10 31.35 28.30 32.13 404.86 50 20.81 38.94 34.33 675.30 74-4 Leaves 2 39.63 19.63 26.34 358.95 10 29.32 20.42 31.61 489.81 50 26.18 31.66 38.66 663.75 74-5 Fruits 2 38.84 10.71 21.99 269.70 10 27.25 27.49 30.64 519.83 50 25.00 39.33 34.38 606.34 74-6 Flowers 2 36.99 10.91 20.25 204.87 10 32.22 22.45 29.59 477.59 50 25.36 38.40 36.91 759.73

TABLE-US-00143 TABLE 143 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 74 Long-stalk low Thalictrum kemense Long-stalk low meadow-rue Fr. meadow-rue Comparative Columbine Thalictrum 3.29 MIC (%) Bacteria: 1 8.2 13.3 Example meadow rue aquilegiifolium MIC (%) Fungi: 1 74-1 Whole plant 0.31 MIC (%) Bacteria: 0.125 15.1 21.5 MIC (%) Fungi: 0.125 74-2 Roots 0.71 MIC (%) Bacteria: 0.25 14.9 18.1 MIC (%) Fungi: 0.5 74-3 Stems 0.46 MIC (%) Bacteria: 0.125 9.0 9.5 MIC (%) Fungi: 0.0625 74-4 Leaves 0.06 MIC (%) Bacteria: 0.0625 18.6 26.1 MIC (%) Fungi: 0.125 74-5 Fruits 0.93 MIC (%) Bacteria: 0.25 11.3 11.8 MIC (%) Fungi: 0.5 74-6 Flowers 0.81 MIC (%) Bacteria: 0.5 26.3 9.4 MIC (%) Fungi: 0.5

EXAMPLE 75

Korean Spice Viburnum

[0175]

TABLE-US-00144 TABLE 144 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 75 Korean spice Viburnum carlesii Korean spice viburnum Hemsl. viburnum Comparative Linden 50 Viburnum Dilatatum 84.07 12.94 6.22 61.57 Example viburnum 75-1 Whole plant 2 34.82 11.78 26.91 210.15 10 27.05 28.23 30.44 542.08 50 21.00 34.30 38.98 662.25 75-2 Roots 2 35.93 11.98 20.09 375.86 10 31.12 25.74 31.19 598.44 50 22.62 30.83 39.49 758.04 75-3 Stems 2 36.85 18.80 22.62 261.05 10 31.59 28.02 31.42 525.80 50 22.87 36.08 39.55 662.72 75-4 Leaves 2 37.64 16.33 24.71 389.70 10 30.85 25.78 33.59 553.58 50 22.67 34.75 34.38 793.82 75-5 Fruits 2 38.79 15.15 20.85 336.66 10 27.83 20.80 28.28 575.45 50 25.71 32.51 35.56 792.88 75-6 Flowers 2 39.50 19.04 25.03 225.12 10 31.42 20.95 29.95 580.31 50 23.38 31.04 39.93 669.19

TABLE-US-00145 TABLE 145 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 75 Korean spice Viburnum carlesii Korean spice viburnum Hemsl. viburnum Comparative Linden Viburnum Dilatatum 5.95 MIC (%) Bacteria: 2 9.1 8.5 Example viburnum MIC (%) Fungi: 1 75-1 Whole plant 0.51 MIC (%) Bacteria: 0.5 17.8 18.2 MIC (%) Fungi: 1 75-2 Roots 0.13 MIC (%) Bacteria: 0.125 14.6 20.0 MIC (%) Fungi: 0.0625 75-3 Stems 0.40 MIC (%) Bacteria: 1 9.0 8.6 MIC (%) Fungi: 1 75-4 Leaves 0.07 MIC (%) Bacteria: 0.125 18.0 15.6 MIC (%) Fungi: 0.125 75-5 Fruits 0.21 MIC (%) Bacteria: 0.25 8.6 18.1 MIC (%) Fungi: 0.125 75-6 Flowers 0.29 MIC (%) Bacteria: 0.25 20.7 16.7 MIC (%) Fungi: 0.5

EXAMPLE 76

Asian Greater Celandine

[0176]

TABLE-US-00146 TABLE 146 Whitening Anti-wrinkle Anti-nflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 76 Asian greater Chelidonium majus Asian greater celandine var. asiaticum celandine (H. Hara) Ohwi 76-1 Whole plant 2 39.13 15.19 23.36 312.25 10 32.88 19.55 33.44 439.24 50 25.55 25.23 38.57 687.41 76-2 Roots 2 36.37 17.69 23.81 320.67 10 30.79 20.97 33.09 467.14 50 23.25 38.50 37.65 600.48 76-3 Stems 2 37.22 7.57 11.82 299.32 10 32.82 14.19 14.78 347.45 50 23.42 18.46 24.50 422.77 76-4 Leaves 2 35.35 7.31 10.46 296.07 10 30.59 19.35 18.97 529.14 50 22.15 28.31 28.18 695.56 76-5 Fruits 2 37.67 9.85 9.20 370.18 10 29.00 13.51 18.96 440.31 50 26.18 26.63 25.44 736.00 76-6 Flowers 2 36.92 7.69 23.57 317.83 10 28.86 10.97 28.82 535.06 50 24.30 18.50 39.20 757.37

TABLE-US-00147 TABLE 147 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 76 Asian greater Chelidonium majus Asian greater celandine var. asiaticum celandine (H. Hara) Ohwi 76-1 Whole plant 1.23 MIC (%) Bacteria: 1 26.7 25.9 MIC (%) Fungi: 1 76-2 Roots 0.66 MIC (%) Bacteria: 0.5 21.2 26.1 MIC (%) Fungi: 1 76-3 Stems 0.96 MIC (%) Bacteria: 0.5 12.2 14.5 MIC (%) Fungi: 1 76-4 Leaves 0.53 MIC (%) Bacteria: 0.5 18.6 18.9 MIC (%) Fungi: 0.5 76-5 Fruits 0.38 MIC (%) Bacteria: 1 10.3 14.1 MIC (%) Fungi: 0.5 76-6 Flowers 0.13 MIC (%) Bacteria: 0.13 22.9 24.3 MIC (%) Fungi: 0.06

EXAMPLE 77

Seashore Spatulate Aster

[0177]

TABLE-US-00148 TABLE 148 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 77 Seashore Aster spathulifolius Seashore spatulate aster Maxim. spatulate aster Comparative Edible aster 50 Aster Scaber 98.28 14.55 1.65 224.15 Example 77-1 Whole plant 2 48.29 8.37 25.85 223.26 10 33.34 15.53 29.34 567.40 50 28.71 29.88 34.47 687.82 77-2 Roots 2 39.11 14.86 23.83 177.39 10 30.82 25.72 27.77 320.56 50 25.02 37.92 35.11 552.69 77-3 Stems 2 34.69 10.71 26.48 160.79 10 30.62 21.81 30.43 240.30 50 20.66 31.94 36.47 400.56 77-4 Leaves 2 36.76 10.31 23.93 155.15 10 27.20 24.88 28.24 265.59 50 21.94 31.69 39.13 415.56 77-5 Fruits 2 39.15 13.67 24.16 343.58 10 30.46 29.49 28.57 557.15 50 23.01 37.04 34.91 768.94 77-6 Flowers 2 24.92 19.52 24.58 201.60 10 20.86 24.74 31.07 566.81 50 16.09 39.88 37.98 731.69

TABLE-US-00149 TABLE 149 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 77 Seashore Aster spathulifolius Seashore spatulate aster Maxim. spatulate aster Comparative Edible aster Aster Scaber 4.99 MIC (%) Bacteria: >2 8.5 9.5 Example MIC (%) Fungi: 2 77-1 Whole plant 0.63 MIC (%) Bacteria: 1 19.7 23.4 MIC (%) Fungi: 0.5 77-2 Roots 0.62 MIC (%) Bacteria: 0.25 11.0 19.4 MIC (%) Fungi: 0.5 77-3 Stems 0.92 MIC (%) Bacteria: 0.25 12.1 13.4 MIC (%) Fungi: 0.5 77-4 Leaves 0.62 MIC (%) Bacteria: 0.5 15.3 16.2 MIC (%) Fungi: 1 77-5 Fruits 0.34 MIC (%) Bacteria: 1 11.8 13.6 MIC (%) Fungi: 0.25 77-6 Flowers 0.07 MIC (%) Bacteria: 0.06 25.4 27.4 MIC (%) Fungi: 0.13

EXAMPLE 78

Leopard Plant

[0178]

TABLE-US-00150 TABLE 150 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 78 Leopard plant Farfugium japonicum Leopard plant (L.) Kitam. 78-1 Whole plant 2 37.02 17.49 24.96 381.68 10 31.43 25.66 28.41 449.98 50 23.44 29.02 33.29 530.61 78-2 Roots 2 39.65 10.71 22.53 213.51 10 29.48 26.00 31.81 425.37 50 24.20 39.45 36.67 653.00 78-3 Stems 2 36.68 19.39 24.79 304.91 10 28.39 25.17 32.37 403.42 50 20.37 37.80 36.68 603.67 78-4 Leaves 2 38.43 16.88 25.17 217.55 10 19.63 24.29 31.88 507.84 50 10.16 39.11 42.41 730.68 78-5 Fruits 2 37.46 12.23 20.48 271.20 10 28.86 21.41 28.30 540.80 50 23.14 28.98 37.67 695.19 78-6 Flowers 2 34.49 10.43 12.89 215.10 10 26.09 29.71 20.46 465.45 50 21.14 34.95 29.30 587.74

TABLE-US-00151 TABLE 151 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 78 Leopard plant Farfugium japonicum Leopard plant (L.) Kitam. 78-1 Whole plant 0.97 MIC (%) Bacteria: 1 19.7 17.2 MIC (%) Fungi: 2 78-2 Roots 0.91 MIC (%) Bacteria: 1 11.6 27.1 MIC (%) Fungi: 1 78-3 Stems 0.47 MIC (%) Bacteria: 0.13 14.3 13.8 MIC (%) Fungi: 0.5 78-4 Leaves 0.22 MIC (%) Bacteria: 0.06 21.6 19.2 MIC (%) Fungi: 0.13 78-5 Fruits 0.53 MIC (%) Bacteria: 0.25 18.8 9.4 MIC (%) Fungi: 0.5 78-6 Flowers 0.98 MIC (%) Bacteria: 0.5 17.8 23.2 MIC (%) Fungi: 1

EXAMPLE 79

Oriental Yellowhead

[0179]

TABLE-US-00152 TABLE 152 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 79 Oriental Inula britannica Oriental yellowhead var. japonica yellowhead (Thunb.) Franch. & Sav. Comparative Elecampane 50 Inula Helenium 78.85 6.33 2.85 26.04 Example Comparative Oriental 50 Inula britannica 62.83 15.61 11.90 207.35 Example yellowhead var. japonica (other area) 79-1 Whole plant 2 39.40 16.42 23.58 316.64 10 30.94 25.94 29.08 449.47 50 20.99 38.51 34.86 708.12 79-2 Roots 2 38.95 19.56 23.68 388.83 10 32.66 21.69 27.59 467.49 50 24.95 35.26 38.62 665.58 79-3 Stems 2 39.53 18.43 24.32 287.87 10 27.35 22.20 31.71 452.08 50 20.65 35.13 37.34 651.19 79-4 Leaves 2 35.83 17.58 22.12 300.59 10 28.16 23.22 28.78 554.62 50 21.77 35.32 34.07 762.71 79-5 Fruits 2 38.69 14.95 24.40 375.27 10 28.60 24.78 27.74 502.59 50 21.08 31.95 34.00 597.14 79-6 Flowers 2 38.45 18.83 22.02 253.82 10 22.67 23.66 27.83 403.15 50 10.09 32.24 35.17 617.58

TABLE-US-00153 TABLE 153 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 79 Oriental Inula britannica Oriental yellowhead var. japonica yellowhead (Thunb.) Franch. & Sav. Comparative Elecampane Inula Helenium 2.17 MIC (%) Bacteria: 2 15.7 15.7 Example MIC (%) Fungi: 2 Comparative Oriental Inula britannica 1.02 MIC (%) Bacteria: 1 12.6 16.3 Example yellowhead var. japonica (other area) MIC (%) Fungi: 1 79-1 Whole plant 0.51 MIC (%) Bacteria: 0.25 26.3 27.7 MIC (%) Fungi: 0.25 79-2 Roots 0.96 MIC (%) Bacteria: 0.5 26.5 21.5 MIC (%) Fungi: 1 79-3 Stems 0.14 MIC (%) Bacteria: 0.25 12.6 16.3 MIC (%) Fungi: 0.5 79-4 Leaves 0.59 MIC (%) Bacteria: 0.13 16.5 13.6 MIC (%) Fungi: 0.25 79-5 Fruits 0.20 MIC (%) Bacteria: 1 11.9 18.7 MIC (%) Fungi: 1 79-6 Flowers 0.29 MIC (%) Bacteria: 0.06 11.6 12.7 MIC (%) Fungi: 0.13

EXAMPLE 80

Giant Butterbur

[0180]

TABLE-US-00154 TABLE 154 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 80 Giant Petasites japonicus Giant butterbur (Siebold & Zucc.) Maxim. butterbur Comparative Reddish 50 Petasites rubellus 70.31 11.69 7.15 48.65 Example butterbur Comparative Giant 50 Petasites japonicus 52.26 21.84 10.48 241.46 Example butterbur (Siebold & Zucc.) Maxim. (other area) 80-1 Whole plant 2 36.16 18.60 25.76 344.43 10 22.43 28.11 27.66 581.22 50 15.90 31.93 37.86 765.16 80-2 Roots 2 36.11 14.10 24.58 218.91 10 29.10 27.85 28.23 600.95 50 22.11 31.10 35.83 723.47 80-3 Stems 2 36.63 13.71 24.18 381.93 10 31.09 20.07 27.38 407.96 50 20.04 38.56 37.08 600.61 80-4 Leaves 2 34.53 16.26 23.31 285.92 10 21.08 27.64 33.28 487.43 50 18.00 38.41 38.35 736.70 80-5 Fruits 2 39.97 15.99 21.06 244.23 10 32.19 24.57 31.53 554.10 50 23.85 34.47 38.93 610.36 80-6 Flowers 2 39.28 10.11 20.54 287.29 10 28.11 24.08 27.91 448.04 50 25.47 37.65 34.46 661.44

TABLE-US-00155 TABLE 155 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 80 Giant Petasites japonicus Giant butterbur (Siebold & Zucc.) Maxim. butterbur Comparative Reddish Petasites rubellus 2.99 MIC (%) Bacteria: >2 12.0 10.3 Example butterbur MIC (%) Fungi: >2 Comparative Giant Petasites japonicus 1.87 MIC (%) Bacteria: 2 10.2 18.9 Example butterbur (Siebold & Zucc.) Maxim. (other area) MIC (%) Fungi: 1 80-1 Whole plant 0.38 MIC (%) Bacteria: 0.25 25.1 25.0 MIC (%) Fungi: 0.5 80-2 Roots 0.80 MIC (%) Bacteria: 0.06 16.2 15.3 MIC (%) Fungi: 0.13 80-3 Stems 0.90 MIC (%) Bacteria: 0.25 19.3 23.1 MIC (%) Fungi: 0.13 80-4 Leaves 0.45 MIC (%) Bacteria: 0.5 12.7 15.0 MIC (%) Fungi: 0.25 80-5 Fruits 0.68 MIC (%) Bacteria: 0.25 8.6 16.1 MIC (%) Fungi: 0.5 80-6 Flowers 0.10 MIC (%) Bacteria: 1 22.5 21.1 MIC (%) Fungi: 0.5

EXAMPLE 81

Ciliated-Fruit Sedge

[0181]

TABLE-US-00156 TABLE 156 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 81 Ciliated-fruit Carex blepharicarpa Ciliated-fruit sedge Franch. sedge Comparative Asiatic sand 50 Carex Kobomugi 93.17 4.27 8.86 28.11 Example sedge 81-1 Whole plant 2 37.52 10.62 26.95 350.96 10 28.47 23.08 28.69 437.36 50 23.20 30.50 34.01 639.16 81-2 Roots 2 39.53 16.95 23.45 195.81 10 33.05 23.10 32.63 288.51 50 20.37 36.96 37.09 581.18 81-3 Stems 2 35.42 10.32 26.54 213.12 10 27.51 22.22 28.64 536.16 50 22.77 37.98 37.07 691.36 81-4 Leaves 2 28.34 14.55 23.74 374.75 10 19.31 23.74 33.17 504.99 50 13.28 45.65 37.12 771.58 81-5 Fruits 2 37.07 15.03 26.86 298.06 10 32.63 23.51 30.93 556.21 50 23.14 33.20 38.25 718.52 81-6 Flowers 2 35.40 11.78 23.45 225.83 10 33.82 20.03 31.87 453.83 50 22.17 30.70 36.25 619.43

TABLE-US-00157 TABLE 157 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 81 Ciliated-fruit Carex blepharicarpa Ciliated-fruit sedge Franch. sedge Comparative Asiatic sand Carex Kobomugi 1.98 MIC (%) Bacteria: >2 8.5 12.2 Example sedge MIC (%) Fungi: >2 81-1 Whole plant 0.47 MIC (%) Bacteria: 1 21.6 25.0 MIC (%) Fungi: 1 81-2 Roots 0.23 MIC (%) Bacteria: 0.5 8.4 15.3 MIC (%) Fungi: 1 81-3 Stems 0.76 MIC (%) Bacteria: 0.5 15.0 13.2 MIC (%) Fungi: 1 81-4 Leaves 0.13 MIC (%) Bacteria: 0.25 25.9 19.8 MIC (%) Fungi: 0.5 81-5 Fruits 0.83 MIC (%) Bacteria: 0.5 21.8 17.9 MIC (%) Fungi: 1 81-6 Flowers 0.46 MIC (%) Bacteria: 0.25 18.6 8.2 MIC (%) Fungi: 0.5

EXAMPLE 82

Short-Stem Sedge

[0182]

TABLE-US-00158 TABLE 158 Whitening Anti-wrinkle Anti-inflammation Melanin Collagen Inhibition of Moisturizing Conc. content synthesis NO production HA synthesis No. Sample (ppm) Scientific name English name (%) (% of control) (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 82 Short-stem Carex breviculmis Short-stem sedge R. Br. sedge Comparative Low sedge 50 Carex Humilis 89.34 13.25 5.25 45.34 Example 82-1 Whole plant 2 38.61 17.53 25.30 257.94 10 29.86 21.83 31.63 498.46 50 20.03 33.36 37.98 714.51 82-2 Roots 2 35.41 11.17 23.44 349.59 10 27.16 23.62 28.01 468.27 50 26.05 32.20 38.67 629.88 82-3 Stems 2 35.33 19.04 23.59 223.74 10 30.11 20.79 30.03 578.94 50 23.08 35.70 36.30 670.06 82-4 Leaves 2 37.71 18.70 24.91 338.20 10 28.03 26.08 33.93 567.39 50 20.86 39.86 35.51 629.76 82-5 Fruits 2 39.94 16.19 20.21 360.14 10 28.84 21.13 31.49 510.49 50 23.33 30.57 38.76 614.23 82-6 Flowers 2 36.86 10.45 23.48 386.61 10 29.72 27.79 29.95 508.71 50 23.40 35.01 37.71 665.17

TABLE-US-00159 TABLE 159 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 inhibition ring inhibition ring No. Sample Scientific name English name (%) Anti-bacteria MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 82 Short-stem Carex breviculmis Short-stem sedge R. Br. sedge Comparative Low sedge Carex Humilis 2.88 MIC (%) Bacteria: 1, 10.6 11.8 Example Fungi: 2 82-1 Whole plant 0.01 MIC (%) Bacteria: 0.5, 27.5 23.7 Fungi: 0.5 82-2 Roots 0.73 MIC (%) Bacteria: 0.5, 14.7 27.3 Fungi: 1 82-3 Stems 0.29 MIC (%) Bacteria: 0.5, 21.8 15.9 Fungi: 1 82-4 Leaves 0.58 MIC (%) Bacteria: 0.5, 16.5 22.7 Fungi: 1 82-5 Fruits 0.32 MIC (%) Bacteria: 1, 11.9 21.1 Fungi: 1 82-6 Flowers 0.18 MIC (%) Bacteria: 1, 23.7 22.2 Fungi: 1

EXAMPLE 83

Purple Maiden Silvergrass

[0183]

TABLE-US-00160 TABLE 160 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 83.sup.  Purple maiden Miscanthus sinensis Purple maiden silvergrass var. purpurascens silvergrass (Andersson) Rendle 83-1 Whole plant 2 39.03 11.88 22.02 208.66 10 29.36 28.64 32.40 512.44 50 22.65 38.06 39.89 782.07 83-2 Roots 2 36.63 15.46 26.33 376.90 10 31.76 20.58 29.54 507.23 50 20.90 33.93 39.74 757.79 83-3 Stems 2 38.13 11.53 25.93 237.31 10 33.89 23.82 32.66 548.94 50 23.01 34.08 35.08 708.87 83-4 Leaves 2 37.56 15.46 26.08 311.02 10 29.54 21.06 27.09 436.41 50 22.68 36.47 34.38 649.40 83-5 Fruits 2 34.90 19.32 25.15 337.01 10 28.59 27.84 31.26 445.49 50 26.34 36.54 39.28 716.12 83-6 Flowers 2 40.02 13.06 24.29 346.16 10 31.66 27.16 30.76 538.04 50 33.58 39.27 39.06 643.95 83-7 Shoots 2 36.46 15.94 24.75 396.58 10 31.84 28.06 28.49 543.09 50 25.99 38.37 37.96 763.88

TABLE-US-00161 TABLE 161 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 83.sup.  Purple maiden Miscanthus sinensis Purple maiden silvergrass var. purpurascens silvergrass (Andersson) Rendle 83-1 Whole plant 0.13 MIC (%) Bacteria: 0.25, Fungi: 0.5 8.5 11.5 83-2 Roots 0.87 MIC (%) Bacteria: 0.25, Fungi: 1 20.4 22.8 83-3 Stems 1.00 MIC (%) Bacteria: 0.5, Fungi: 1 15.3 14.0 83-4 Leaves 0.53 MIC (%) Bacteria: 0.25, Fungi: 1 13.7 25.6 83-5 Fruits 0.43 MIC (%) Bacteria: 0.5, Fungi: 1 10.2 18.3 83-6 Flowers 1.00 MIC (%) Bacteria: 0.5, Fungi: 1 16.8 10.6 83-7 Shoots 0.31 MIC (%) Bacteria: 1, Fungi: 1 15.6 10.2

EXAMPLE 84

Foxtail Fountaingrass

[0184]

TABLE-US-00162 TABLE 162 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 84.sup.  Foxtail Pennisetum alopecuroides Foxtail fountaingrass (L.) Spreng. fountaingrass 84-1 Whole plant 2 35.76 15.10 25.60 297.20 10 33.30 20.69 32.93 580.00 50 25.09 38.83 39.08 768.17 84-2 Roots 2 36.01 13.59 22.23 382.22 10 30.89 28.08 31.75 511.86 50 25.71 36.15 34.00 784.58 84-3 Stems 2 35.63 10.03 23.51 210.50 10 28.18 26.17 32.33 435.07 50 22.99 30.63 38.16 677.66 84-4 Leaves 2 36.35 17.10 20.69 250.56 10 27.02 25.27 31.15 432.31 50 25.57 30.78 39.43 615.15 84-5 Fruits 2 38.55 12.38 20.60 395.00 10 30.40 26.52 32.43 484.93 50 21.20 33.61 35.32 765.38 84-6 Flowers 2 34.10 13.62 21.64 334.94 10 33.70 25.06 27.64 550.19 50 20.91 38.10 39.99 696.47

TABLE-US-00163 TABLE 163 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 84.sup.  Foxtail Pennisetum Foxtail fountaingrass alopecuroides fountaingrass (L.) Spreng. 84-1 Whole plant 0.46 MIC (%) Bacteria: 0.25, Fungi: 0.5 20.8 10.5 84-2 Roots 0.30 MIC (%) Bacteria: 0.25, Fungi: 0.25 18.1 12.9 84-3 Stems 0.14 MIC (%) Bacteria: 0.25, Fungi: 0.5 8.7 10.6 84-4 Leaves 0.59 MIC (%) Bacteria: 0.125, Fungi: 0.5 19.0 17.3 84-5 Fruits 0.41 MIC (%) Bacteria: 0.5, Fungi: 1 23.8 18.9 84-6 Flowers 0.80 MIC (%) Bacteria: 0.5, Fungi: 0.5 24.5 21.6

EXAMPLE 85

Arrow Bamboo

[0185]

TABLE-US-00164 TABLE 164 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 85.sup.  Arrow Pseudosasa japonica Arrow bamboo (Siebold & Zucc. ex bamboo Steud.) Makino ex Nakai 85-1 Whole plant 2 34.10 10.38 23.30 383.43 10 27.82 22.15 29.26 487.01 50 21.14 37.72 37.60 670.70 85-2 Roots 2 39.91 18.59 25.36 291.57 10 32.18 22.18 32.33 514.92 50 25.95 30.55 39.69 760.62 85-3 Stems 2 37.19 13.84 22.84 334.32 10 29.91 26.16 28.35 428.80 50 24.21 37.62 37.92 682.60 85-4 Leaves 2 37.79 18.70 21.19 327.69 10 28.85 20.88 33.08 427.86 50 23.31 35.18 35.00 688.70 85-5 Fruits 2 38.82 19.23 21.75 280.47 10 28.73 25.12 29.53 451.83 50 26.27 37.74 38.96 659.56 85-6 Flowers 2 36.34 11.94 25.48 338.69 10 32.61 20.20 32.44 522.43 50 20.70 39.85 35.43 676.44

TABLE-US-00165 TABLE 165 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 85.sup.  Arrow Pseudosasa japonica Arrow bamboo (Siebold & Zucc. ex bamboo Steud.) Makino ex Nakai 85-1 Whole plant 0.05 MIC (%) Bacteria: 1, Fungi: 0.5 9.2 8.2 85-2 Roots 0.62 MIC (%) Bacteria: 1, Fungi: 1 15.3 21.0 85-3 Stems 0.29 MIC (%) Bacteria: 1, Fungi: 1 17.2 11.6 85-4 Leaves 0.77 MIC (%) Bacteria: 1, Fungi: 2 13.3 13.6 85-5 Fruits 0.81 MIC (%) Bacteria: 1, Fungi: 2 25.4 16.7 85-6 Flowers 0.89 MIC (%) Bacteria: 2, Fungi: 2 13.1 25.2

EXAMPLE 86

Kuril Bamboo

[0186]

TABLE-US-00166 TABLE 166 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 86.sup.  Kuril Sasa kurilensis Kuril bamboo (Rupr.) Makino bamboo & Shibata Comparative Broad-leaf 50 Sasa Quelpaertensis 79.24 10.16 2.63 54.12 Example bamboo 86-1 Whole plant 2 36.69 11.30 23.45 218.11 10 33.30 20.52 27.47 502.12 50 23.80 39.83 35.59 784.92 86-2 Roots 2 35.95 17.65 26.43 383.82 10 28.02 25.94 30.14 444.50 50 25.04 38.57 36.98 620.66 86-3 Stems 2 36.09 17.40 25.43 231.46 10 32.47 22.22 27.83 402.96 50 22.22 37.04 37.63 632.78 86-4 Leaves 2 40.02 11.89 19.26 244.93 10 31.66 20.62 22.95 414.63 50 33.58 27.27 28.13 522.10 86-5 Fruits 2 35.01 16.49 26.46 321.37 10 30.26 21.44 27.34 407.73 50 24.00 35.02 39.62 755.24 86-6 Flowers 2 38.28 12.18 23.83 293.99 10 27.01 20.78 31.10 493.78 50 22.72 34.21 34.81 760.55

TABLE-US-00167 TABLE 167 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 86.sup.  Kuril Sasa kurilensis Kuril bamboo (Rupr.) Makino bamboo & Shibata Comparative Broad-leaf Sasa Quelpaertensis 1.99 MIC (%) Bacteria: 1, Fungi: >2 11.0 11.5 Example bamboo 86-1 Whole plant 0.25 MIC (%) Bacteria: 0.25, Fungi: 0.25 26.3 27.6 86-2 Roots 0.29 MIC (%) Bacteria: 0.25, Fungi: 0.25 26.3 24.9 86-3 Stems 0.43 MIC (%) Bacteria: 0.25, Fungi: 0.5 26.3 16.2 86-4 Leaves 0.73 MIC (%) Bacteria: 1, Fungi: 1 11.8 22.6 86-5 Fruits 0.35 MIC (%) Bacteria: 0.5, Fungi: 0.5 13.2 11.3 86-6 Flowers 0.03 MIC (%) Bacteria: 1, Fungi: 0.5 21.0 22.8

EXAMPLE 87

Shrubby Sophora

[0187]

TABLE-US-00168 TABLE 168 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 87.sup.  Shrubby Sophora flavescens Shrubby sophora sophora Alton Comparative Locust 50 Sophora Japonica 84.16 2.36 5.74 58.32 Example tree Comparative Shrubby 50 78.69 9.98 8.21 187.81 Example sophora (other area) 87-1 Whole plant 2 35.71 16.45 24.31 266.69 10 27.05 21.57 31.83 407.30 50 24.04 32.75 35.76 769.95 87-2 Roots 2 37.62 7.36 18.60 283.58 10 34.58 20.31 22.54 392.98 50 31.63 29.93 30.24 620.84 87-3 Stems 2 36.67 14.36 23.01 273.46 10 27.59 24.18 33.42 594.25 50 24.30 32.64 34.29 620.55 87-4 Leaves 2 36.18 17.46 25.26 347.28 10 32.57 21.19 33.49 525.14 50 22.22 33.51 38.68 686.58 87-5 Fruits 2 34.42 16.78 23.62 320.67 10 28.15 26.13 31.56 471.56 50 24.51 32.79 39.76 699.91 87-6 Flowers 2 36.80 11.41 22.50 312.28 10 29.38 23.60 28.09 435.20 50 20.98 37.10 37.72 763.64

TABLE-US-00169 TABLE 169 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 87.sup.  Shrubby Sophora flavescens Shrubby sophora Alton sophora Comparative Locust Sophora Japonica 3.84 MIC (%) Bacteria: >2, Fungi: >2 8.4 10.0 Example tree Comparative Shrubby 2.77 MIC (%) Bacteria: >2, Fungi: 2 13.3 14.3 Example sophora (other area) 87-1 Whole plant 0.24 MIC (%) Bacteria: 2, Fungi: 1 24.6 25.6 87-2 Roots 0.64 MIC (%) Bacteria: 1, Fungi: 1 13.3 14.3 87-3 Stems 0.25 MIC (%) Bacteria: 1, Fungi: 1 10.4 16.5 87-4 Leaves 0.22 MIC (%) Bacteria: 1, Fungi: 1 14.7 19.3 87-5 Fruits 0.38 MIC (%) Bacteria: 2, Fungi: 1 24.3 21.5 87-6 Flowers 0.17 MIC (%) Bacteria: 2, Fungi: 1 15.7 14.8

EXAMPLE 88

Orange Daylily

[0188]

TABLE-US-00170 TABLE 170 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 88.sup.  Orange Hemerocallis fulva Orange Daylily (L.) L. Daylily 88-1 Whole plant 2 37.98 13.04 20.78 320.33 10 28.74 21.75 28.83 527.62 50 24.73 30.10 36.08 684.39 88-2 Roots 2 39.51 11.81 25.71 271.10 10 33.78 20.80 28.00 548.53 50 20.02 37.07 39.09 775.77 88-3 Stems 2 36.89 11.44 23.02 251.80 10 28.32 22.77 33.82 481.36 50 23.54 31.80 39.77 707.59 88-4 Leaves 2 36.53 15.14 21.79 235.29 10 31.61 21.43 32.98 451.04 50 22.27 37.44 38.24 717.18 88-5 Fruits 2 39.44 10.83 24.71 389.37 10 30.76 25.35 28.14 534.34 50 20.69 37.78 38.18 707.43 88-6 Flowers 2 36.56 19.96 24.00 377.30 10 30.27 21.01 33.66 530.00 50 26.94 34.60 37.84 643.38

TABLE-US-00171 TABLE 171 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 88.sup.  Orange Hemerocallis fulva Orange Daylily (L.) L. Daylily 88-1 Whole plant 0.66 MIC (%) Bacteria: 0.5 14.0 22.4 MIC (%) Fungi: 0.5 17.0 20.1 88-2 Roots 0.58 MIC (%) Bacteria: 0.125 24.1 14.5 MIC (%) Fungi: 0.5 88-3 Stems 0.77 MIC (%) Bacteria: 0.25 9.1 18.2 MIC (%) Fungi: 0.25 88-4 Leaves 0.33 MIC (%) Bacteria: 0.25 22.8 11.9 MIC (%) Fungi: 0.25 88-5 Fruits 0.31 MIC (%) Bacteria: 0.25 22.8 16.7 MIC (%) Fungi: 0.5 88-6 Flowers 0.90 MIC (%) Bacteria: 0.5 25.4 27.4 MIC (%) Fungi: 0.5

EXAMPLE 89

Tiger Lily

[0189]

TABLE-US-00172 TABLE 172 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 89.sup.  Tiger lily Lilium lancifolium Tiger lily Thunb. Comparative Madonna 50 Lilium Candidum 91.19 9.96 3.61 47.97 Example lily 89-1 Whole plant 2 39.52 13.32 24.32 235.37 10 29.17 22.48 30.99 483.99 50 21.63 30.01 35.52 630.93 89-2 Roots 2 37.97 12.02 25.41 350.39 10 30.41 22.20 33.79 596.41 50 20.11 30.76 37.90 702.51 89-3 Stems 2 37.99 15.57 20.64 349.00 10 29.24 21.67 33.58 499.76 50 20.10 34.32 37.25 685.50 89-4 Leaves 2 38.52 15.67 22.66 336.67 10 33.02 21.75 32.58 494.37 50 21.60 35.88 37.64 768.26 89-5 Flowers 2 34.53 17.41 22.86 358.56 10 29.14 29.79 28.38 446.04 50 22.38 30.41 36.03 656.42 89-6 Bulbils 2 39.71 12.13 22.84 246.72 10 32.18 21.37 31.65 481.46 50 20.16 31.03 37.85 769.88

TABLE-US-00173 TABLE 173 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 89.sup.  Tiger lily Lilium lancifolium Tiger lily Thunb. Comparative Madonna Lilium Candidum 2.79 MIC (%) Bacteria: 1 8.1 8.5 Example lily MIC (%) Fungi: 1 89-1 Whole plant 0.90 MIC (%) Bacteria: 0.25 19.7 15.5 MIC (%) Fungi: 0.125 89-2 Roots 0.16 MIC (%) Bacteria: 0.0625 17.0 10.1 MIC (%) Fungi: 0.125 89-3 Stems 0.84 MIC (%) Bacteria: 0.125 9.8 8.1 MIC (%) Fungi: 0.125 89-4 Leaves 0.20 MIC (%) Bacteria: 0.125 11.4 8.5 MIC (%) Fungi: 0.125 89-5 Flowers 0.96 MIC (%) Bacteria: 0.25 19.5 22.7 MIC (%) Fungi: 0.25 89-6 Bulbils 0.12 MIC (%) Bacteria: 0.25 26.5 26.7 MIC (%) Fungi: 0.25

EXAMPLE 90

Big Blue Lilyturf

[0190]

TABLE-US-00174 TABLE 174 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 90.sup.  Big blue Liriope platyphylla Big blue lilyturf F. T. Wang & T. Tang lilyturf Comparative Creeping 50 Liriope Spicata 79.02 11.65 3.77 22.75 Example lilyturf 90-1 Whole plant 2 36.28 15.62 21.68 218.04 10 33.12 26.66 33.28 538.92 50 20.99 30.59 34.15 666.45 90-2 Roots 2 37.06 12.96 25.91 235.68 10 29.27 25.34 27.61 535.22 50 24.37 35.75 37.30 654.28 90-3 Stems 2 36.28 15.80 25.75 333.69 10 33.12 21.84 32.63 453.20 50 20.99 39.11 39.29 800.22 90-4 Leaves 2 36.53 12.80 23.78 267.73 10 31.21 28.79 29.63 513.82 50 21.89 32.55 39.02 741.53 90-5 Fruits 2 38.19 19.02 20.59 274.84 10 33.42 23.29 30.95 516.84 50 23.14 35.83 35.38 689.71 90-6 Flowers 2 34.45 14.98 23.07 220.38 10 30.70 25.54 30.03 465.53 50 23.21 37.18 38.36 790.45

TABLE-US-00175 TABLE 175 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 90.sup.  Big blue Liriope platyphylla Big blue lilyturf F. T. Wang & T. Tang lilyturf Comparative Creeping Liriope Spicata 1.06 MIC (%) Bacteria: >2 7.5 9.4 Example lilyturf MIC (%) Fungi: 1 90-1 Whole plant 0.20 MIC (%) Bacteria: 0.5 20.4 18.4 MIC (%) Fungi: 0.5 90-2 Roots 0.65 MIC (%) Bacteria: 0.5 15.3 11.5 MIC (%) Fungi: 0.5 90-3 Stems 0.02 MIC (%) Bacteria: 0.125 20.2 10.0 MIC (%) Fungi: 0.25 90-4 Leaves 0.53 MIC (%) Bacteria: 0.5 14.8 8.7 MIC (%) Fungi: 0.5 90-5 Fruits 0.92 MIC (%) Bacteria: 0.5 11.8 26.9 MIC (%) Fungi: 0.5 90-6 Flowers 0.52 MIC (%) Bacteria: 0.5 18.2 20.9 MIC (%) Fungi: 0.5

EXAMPLE 91

False Lily of the Valley

[0191]

TABLE-US-00176 TABLE 176 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 91.sup.  False lily Maianthemum dilatatum False lily of the (A.W. Wood) A. Nelson of the valley & J. F. Macbr. valley Comparative Two leaf 50 Maianthemum Japonicum 68.47 15.36 2.03 63.06 Example beadruby 91-1 Whole plant 2 39.69 11.91 24.67 280.91 10 31.08 29.05 29.35 547.20 50 24.36 38.76 34.63 737.43 91-2 Roots 2 39.29 13.13 23.81 352.54 10 30.16 29.89 27.70 528.31 50 22.96 34.60 38.86 679.29 91-3 Stems 2 36.63 13.78 25.15 213.50 10 30.18 27.28 31.66 462.46 50 22.69 33.82 34.62 651.68 91-4 Leaves 2 36.92 18.88 24.81 287.61 10 32.91 24.61 28.83 515.62 50 21.78 34.96 34.70 744.82 91-5 Fruits 2 35.29 14.00 26.00 200.58 10 30.08 22.85 27.38 517.51 50 24.36 35.25 34.24 797.02 91-6 Flowers 2 38.31 12.23 23.07 215.65 10 31.99 22.10 33.41 433.02 50 25.87 35.92 38.31 667.41

TABLE-US-00177 TABLE 177 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 91.sup.  False lily Maianthemum dilatatum False lily of the (A. W. Wood) A. Nelson of the valley & J. F. Macbr. valley Comparative Two leaf Maianthemum Japonicum 2.62 MIC (%) Bacteria: >2 8.8 13.8 Example beadruby MIC (%) Fungi: >2 91-1 Whole plant 0.75 MIC (%) Bacteria: 0.25 26.1 25.6 MIC (%) Fungi: 0.5 91-2 Roots 0.83 MIC (%) Bacteria: 0.25 8.4 12.1 MIC (%) Fungi: 0.5 91-3 Stems 0.83 MIC (%) Bacteria: 0.5 11.1 12.0 MIC (%) Fungi: 0.5 91-4 Leaves 0.07 MIC (%) Bacteria: 0.5 21.7 11.4 MIC (%) Fungi: 0.5 91-5 Fruits 0.12 MIC (%) Bacteria: 0.5 17.6 13.0 MIC (%) Fungi: 0.5 91-6 Flowers 0.40 MIC (%) Bacteria: 0.125 22.2 15.6 MIC (%) Fungi: 0.5

EXAMPLE 92

Japanese Cedar

[0192]

TABLE-US-00178 TABLE 178 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 92.sup.  Japanese Cryptomeria japonica Japanese Cedar (Thunb. ex L. f.) D. Don Cedar 92-1 Whole plant 2 36.30 15.02 23.78 354.26 10 30.84 21.01 28.02 503.21 50 24.40 34.55 37.62 728.82 92-2 Roots 2 35.79 19.46 26.90 301.93 10 30.33 20.37 32.60 417.33 50 22.32 39.71 35.33 623.10 92-3 Stems 2 38.14 12.06 25.08 329.44 10 31.14 24.50 29.49 492.00 50 26.34 36.67 35.22 718.87 92-4 Leaves 2 39.48 16.24 21.41 220.60 10 32.69 26.50 30.03 514.35 50 25.82 34.88 36.60 631.17 92-5 Fruits 2 39.66 17.94 23.30 361.41 10 32.75 29.78 29.76 529.77 50 20.62 36.77 39.47 749.19 92-6 Flowers 2 39.26 19.46 24.57 250.21 10 32.60 20.37 32.70 514.83 50 21.44 39.71 39.94 795.60

TABLE-US-00179 TABLE 179 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 92.sup.  Japanese Cryptomeria japonica Japanese Cedar (Thunb. ex L. f.) D. Don Cedar 92-1 Whole plant 0.73 MIC (%) Bacteria: 0.25 22.0 14.8 MIC (%) Fungi: 0.125 92-2 Roots 0.85 MIC (%) Bacteria: 1 22.4 18.1 MIC (%) Fungi: 0.5 92-3 Stems 0.88 MIC (%) Bacteria: 0.25 26.4 15.4 MIC (%) Fungi: 0.125 92-4 Leaves 0.44 MIC (%) Bacteria: 0.125 20.0 20.0 MIC (%) Fungi: 0.125 92-5 Fruits 0.20 MIC (%) Bacteria: 0.125 14.5 21.8 MIC (%) Fungi: 0.125 92-6 Flowers 0.11 MIC (%) Bacteria: 0.0625 9.6 17.3 MIC (%) Fungi: 0.125

EXAMPLE 93

Thunberg's Bay-Tree

[0193]

TABLE-US-00180 TABLE 180 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 93.sup.  Thunberg's Machilus thunbergii Thunberg's bay-tree Siebold & Zucc. bay-tree Comparative Long-leaf 50 Machilus Japonica 72.02 15.14 3.48 52.02 Example bay-tree 93-1 Whole plant 2 35.10 15.72 22.14 379.32 10 30.25 22.38 27.45 526.57 50 25.92 33.30 37.72 558.70 93-2 Roots 2 34.41 17.68 26.71 378.76 10 29.43 24.14 28.32 474.32 50 20.79 39.91 39.34 730.56 93-3 Stems 2 39.83 19.84 25.68 390.29 10 27.37 20.42 27.16 526.15 50 25.05 34.21 35.82 610.22 93-4 Leaves 2 38.38 19.72 25.63 394.02 10 33.14 25.16 28.62 509.90 50 24.39 35.19 34.16 688.03 93-5 Fruits 2 37.44 17.07 23.55 316.07 10 33.88 22.85 32.91 415.77 50 22.37 33.58 37.72 726.90 93-6 Flowers 2 36.00 11.82 24.25 295.86 10 33.60 23.98 28.94 454.25 50 21.13 38.66 39.13 741.08

TABLE-US-00181 TABLE 181 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 93.sup.  Thunbergs's Machilus thunbergii Thunberg's bay-tree Siebold & Zucc. bay-tree Comparative Long-leaf Machilus Japonica 3.83 MIC (%) Bacteria: 1 10.6 8.8 Example bay-tree MIC (%) Fungi: 1 93-1 Whole plant 0.38 MIC (%) Bacteria: 0.125 19.6 23.8 MIC (%) Fungi: 0.25 93-2 Roots 0.19 MIC (%) Bacteria: 0.0625 10.9 10.7 MIC (%) Fungi: 0.125 93-3 Stems 0.56 MIC (%) Bacteria: 0.125 25.4 19.2 MIC (%) Fungi: 0.25 93-4 Leaves 0.99 MIC (%) Bacteria: 0.25 20.8 16.0 MIC (%) Fungi: 0.25 93-5 Fruits 0.15 MIC (%) Bacteria: 0.25 18.9 13.6 MIC (%) Fungi: 0.25 93-6 Flowers 0.16 MIC (%) Bacteria: 0.0625 21.4 20.5 MIC (%) Fungi: 0.125

EXAMPLE 94

Ulleungdo White Pine

[0194]

TABLE-US-00182 TABLE 182 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 94.sup.  Ulleungdo Pinus parviflora Ulleungdo white pine Siebold & Zucc. white pine Comparative Pine 50 Pinus Densiflora 87.79 13.37 3.97 31.05 Example 94-1 Whole plant 2 38.93 11.25 25.19 273.52 10 31.66 28.42 32.73 500.18 50 26.31 34.60 37.76 721.72 94-2 Roots 2 34.39 18.43 22.42 346.78 10 28.45 27.11 32.16 580.48 50 25.61 35.25 39.65 638.27 94-3 Stems 2 37.91 12.94 22.82 226.97 10 32.08 25.55 27.32 511.27 50 23.50 34.55 36.02 784.68 94-4 Leaves 2 35.80 12.34 23.15 345.49 10 27.95 24.12 27.39 489.33 50 23.86 34.03 37.89 661.08 94-5 Fruits 2 37.44 13.47 21.85 359.25 10 29.42 29.91 29.66 479.81 50 25.52 34.13 35.39 693.26 94-6 Flowers 2 37.53 11.83 23.19 338.99 10 31.26 25.13 33.00 410.46 50 23.39 36.39 37.04 740.36

TABLE-US-00183 TABLE 183 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 94.sup.  Ulleungdo Pinus parviflora Ulleungdo white pine Siebold & Zucc. white pine Comparative Pine Pinus Densiflora 2.17 MIC (%) Bacteria: 2, Fungi: 1 12.1 8.5 Example 94-1 Whole plant 0.19 MIC (%) Bacteria: 0.25, Fungi: 0.125 21.2 20.4 94-2 Roots 0.52 MIC (%) Bacteria: 0.5, Fungi: 0.125 10.4 8.0 94-3 Stems 0.51 MIC (%) Bacteria: 1, Fungi: 0.5 15.6 21.4 94-4 Leaves 0.03 MIC (%) Bacteria: 1, Fungi: 0.5 9.2 10.1 94-5 Fruits 1.64 MIC (%) Bacteria: 1, Fungi: 0.5 25.7 22.8 94-6 Flowers 0.76 MIC (%) Bacteria: 1, Fungi: 0.25 14.8 8.7

EXAMPLE 95

Ulleungdo Hemlock

[0195]

TABLE-US-00184 TABLE 184 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 95.sup.  Ulleungdo Tsuga sieboldii Ulleungdo hemlock Carriere hemlock Comparative Hemlock 50 Tsuga canadensis Hemlock 74.82 8.41 2.28 16.30 Example Canada Canada 95-1 Whole plant 2 39.19 14.51 24.36 207.94 10 29.65 29.09 30.11 479.80 50 23.79 38.83 39.71 731.43 95-2 Roots 2 35.35 19.28 25.52 388.94 10 29.73 26.19 33.31 573.58 50 21.62 33.62 38.45 783.42 95-3 Stems 2 36.22 17.32 23.21 385.12 10 31.88 22.92 32.87 427.78 50 26.93 34.43 36.41 768.26 95-4 Leaves 2 34.76 19.68 22.47 288.96 10 32.14 25.87 33.83 553.28 50 22.23 30.28 38.86 712.88 95-5 Fruits 2 36.55 15.64 23.12 388.88 10 30.46 27.53 32.29 454.38 50 25.79 31.31 38.77 775.92 95-6 Flowers 2 39.06 17.33 21.53 349.44 10 30.90 27.00 33.63 593.31 50 21.29 31.70 34.12 605.01

TABLE-US-00185 TABLE 185 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 95.sup.  Ulleungdo Tsuga sieboldii Ulleungdo hemlock Carriere hemlock Comparative Hemlock Tsuga canadensis Hemlock 5.27 MIC (%) Bacteria: 1, Fungi: 1 10.4 12.5 Example Canada Canada 95-1 Whole plant 0.95 MIC (%) Bacteria: 0.25, Fungi: 0.125 22.8 23.3 95-2 Roots 0.47 MIC (%) Bacteria: 0.5, Fungi: 0.125 17.8 13.3 95-3 Stems 0.49 MIC (%) Bacteria: 0.5, Fungi: 0.25 11.6 27.7 95-4 Leaves 0.97 MIC (%) Bacteria: 0.5, Fungi: 0.5 21.1 19.2 95-5 Fruits 0.09 MIC (%) Bacteria: 0.25, Fungi: 0.5 21.6 18.5 95-6 Flowers 0.65 MIC (%) Bacteria: 0.25, Fungi: 0.25 16.1 19.3

EXAMPLE 96

Sericeous Newlitsea

[0196]

TABLE-US-00186 TABLE 186 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 96.sup.  Sericeous Neolitsea sericea Sericeous newlitsea (Blume) Koidz. newlitsea Comparative Irregular- 50 Neolitsea Aciculata 88.42 13.32 5.19 48.14 Example streak newlitse Comparative Sericeous 50 51.97 28.04 12.61 128.55 Example newlitsea (other area) 96-1 Whole plant 2 39.34 18.54 26.82 304.91 10 29.28 29.33 31.15 517.54 50 24.34 32.39 34.67 682.31 96-2 Roots 2 38.83 19.79 21.57 279.62 10 33.91 22.95 27.06 451.86 50 23.58 31.59 37.23 786.36 96-3 Stems 2 34.98 15.11 25.78 336.77 10 27.45 22.46 28.84 593.32 50 25.89 39.98 36.34 608.09 96-4 Leaves 2 36.39 16.78 23.05 348.61 10 28.44 29.58 28.56 404.71 50 20.67 32.68 35.96 740.33 96-5 Fruits 2 36.34 15.63 24.29 246.28 10 30.18 22.47 32.07 526.73 50 23.31 37.91 38.53 745.39 96-6 Flowers 2 34.67 12.94 24.72 368.41 10 28.46 27.60 30.41 519.83 50 20.06 35.61 39.32 638.49

TABLE-US-00187 TABLE 187 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 96.sup.  Sericeous Neolitsea sericea Sericeous newlitsea (Blume) Koidz. newlitsea Comparative Irregular- Neolitsea Aciculata 3.34 MIC (%) Bacteria: 1, Fungi: 1 9.9 12.5 Example streak newlitse Comparative Sericeous 2.20 MIC (%) Bacteria: 0.5, Fungi: 0.5 12.8 10.5 Example newlitsea (other area) 96-1 Whole plant 0.55 MIC (%) Bacteria: 0.25, Fungi: 0.125 25.7 20.2 96-2 Roots 0.25 MIC (%) Bacteria: 0.25, Fungi: 0.125 9.1 14.7 96-3 Stems 0.53 MIC (%) Bacteria: 0.5, Fungi: 0.125 11.8 14.9 96-4 Leaves 0.53 MIC (%) Bacteria: 0.125, Fungi: 18.9 24.7 96-5 Fruits 0.66 MIC (%) Bacteria: 0.25, Fungi: 0.125 11.1 8.8 96-6 Flowers 0.79 MIC (%) Bacteria: 0.125, Fungi: 11.1 9.2

EXAMPLE 97

Macropodous Daphniphyllum

[0197]

TABLE-US-00188 TABLE 188 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA (5 ppm) EGF group (200 ppm) (10 ppb) 28% (10 ppb) 35% 25% 320% 97.sup.  Macropodous Daphniphyllum Macropodous daphniphyllum macropodum daphniphyllum Miq. Comparative Macropodous 50 86.33 20.09 12.68 200.48 Example daphniphyllum (other area) 97-1 Whole plant 2 36.03 12.81 21.30 315.68 10 33.64 26.96 27.97 471.27 50 23.97 33.97 38.75 669.01 97-2 Roots 2 37.35 19.39 25.46 294.80 10 33.92 23.04 30.49 594.31 50 23.00 34.53 36.01 644.03 97-3 Stems 2 35.13 17.65 23.22 324.16 10 29.16 22.15 30.17 561.48 50 25.48 36.50 38.96 685.10 97-4 Leaves 2 37.96 17.87 20.26 291.97 10 31.75 28.92 33.05 448.11 50 23.80 35.85 38.30 759.30 97-5 Fruits 2 38.26 14.07 23.66 224.42 10 32.05 21.70 28.96 497.40 50 24.61 34.91 38.80 616.34 97-6 Flowers 2 34.69 12.81 22.34 351.72 10 27.42 28.15 30.37 442.03 50 24.74 38.75 38.48 737.36

TABLE-US-00189 TABLE 189 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 97.sup.  Macropodous Daphniphyllum Macropodous daphniphyllum macropodum daphniphyllum Miq. Comparative Macropodous 2.93 MIC (%) Bacteria: 2, Fungi: >2 9.2 10.9 Example daphniphyllum (other area) 97-1 Whole plant 0.11 MIC (%) Bacteria: 0.25, Fungi: 0.25 22.3 18.2 97-2 Roots 0.59 MIC (%) Bacteria: 1, Fungi: 1 16.7 17.3 97-3 Stems 0.46 MIC (%) Bacteria: 1, Fungi: 0.5 11.4 12.9 97-4 Leaves 0.78 MIC (%) Bacteria: 1, Fungi: 1 11.7 14.0 97-5 Fruits 0.84 MIC (%) Bacteria: 1, Fungi: 0.125 22.8 26.5 97-6 Flowers 0.20 MIC (%) Bacteria: 2, Fungi: 0.25 11.7 14.0

EXAMPLE 98

Scabrous Aphananthe

[0198]

TABLE-US-00190 TABLE 190 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 98.sup.  Scabrous Aphananthe aspera Scabrous aphananthe (Thuhb.) Planch. aphananthe 98-1 Whole plant 2 37.27 10.19 25.96 397.89 10 33.68 22.01 29.15 489.62 50 23.98 31.31 34.20 780.90 98-2 Roots 2 39.54 12.09 23.63 319.91 10 32.19 24.55 33.61 558.41 50 26.26 36.26 37.69 662.14 98-3 Stems 2 39.80 13.26 25.11 220.23 10 32.14 26.11 28.71 418.84 50 25.72 36.21 35.19 709.86 98-4 Leaves 2 34.55 12.53 24.37 346.40 10 27.50 21.68 31.81 425.57 50 24.01 32.27 39.71 692.42 98-5 Fruits 2 37.52 19.31 26.97 281.53 10 28.16 28.25 33.39 492.77 50 23.23 37.27 34.12 719.27 98-6 Flowers 2 35.43 15.61 26.44 202.59 10 32.70 21.69 28.29 575.13 50 20.96 38.78 35.77 643.11

TABLE-US-00191 TABLE 191 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 98.sup.  Scabrous Aphananthe aspera Scabrous aphananthe (Thunb.) Planch. aphananthe 98-1 Whole plant 0.98 MIC (%) Bacteria: 0.25, Fungi: 0.5 9.6 15.4 98-2 Roots 0.50 MIC (%) Bacteria: 1, Fungi: 0.5 11.9 23.6 98-3 Stems 0.55 MIC (%) Bacteria: 1, Fungi: 1 18.6 24.8 98-4 Leaves 0.71 MIC (%) Bacteria: 2, Fungi: 0.5 8.1 23.2 98-5 Fruits 0.08 MIC (%) Bacteria: 2, Fungi: 0.5 25.8 8.1 98-6 Flowers 0.93 MIC (%) Bacteria: 1, Fungi: 1 23.2 26.7

EXAMPLE 99

Caudate-Leaf Hackberry

[0199]

TABLE-US-00192 TABLE 192 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 99.sup.  Caudate-leaf Celtis jessoensis Caudate-leaf hackberry Koidz. hackberry 99-1 Whole plant 2 38.27 12.93 22.01 260.48 10 29.82 25.32 27.30 442.13 50 23.54 37.22 35.10 689.05 99-2 Roots 2 38.72 12.15 26.89 360.54 10 28.36 29.21 33.03 481.15 50 26.85 32.44 37.67 721.53 99-3 Stems 2 36.34 14.04 24.10 267.66 10 30.97 29.47 28.18 452.55 50 20.99 39.53 36.45 617.98 99-4 Leaves 2 34.43 13.73 21.01 249.50 10 32.92 29.62 26.49 592.59 50 22.34 33.36 27.10 670.09 99-5 Fruits 2 36.17 11.91 24.72 329.09 10 32.29 21.27 27.46 471.02 50 26.61 35.51 36.19 773.26 99-6 Flowers 2 38.00 10.02 22.64 285.34 10 31.73 25.07 31.70 526.82 50 22.83 30.45 34.72 697.25

TABLE-US-00193 TABLE 193 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 99.sup.  Caudate-leaf Celtis jessoensis Caudate-leaf hackberry Koidz. hackberry 99-1 Whole plant 0.61 MIC (%) Bacteria: 0.25, Fungi: 0.25 16.9 11.2 99-2 Roots 0.32 MIC (%) Bacteria: 1, Fungi: 0.125 17.0 23.5 99-3 Stems 0.50 MIC (%) Bacteria: 1, Fungi: 0.5 19.6 23.4 99-4 Leaves 0.65 MIC (%) Bacteria: 0.5, Fungi: 1 22.3 20.7 99-5 Fruits 0.67 MIC (%) Bacteria: 2, Fungi: 0.5 20.5 8.1 99-6 Flowers 0.95 MIC (%) Bacteria: 1, Fungi: 0.5 21.0 23.7

EXAMPLE 100

Manchurian Elm

[0200]

TABLE-US-00194 TABLE 194 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 100.sup.  Manchurian Ulmus laciniata Manchurian Elm (Trautv.) Mayr Elm Comparative Elm 50 Ulmus Davidiana 74.42 8.50 3.79 36.63 Example 100-1 Whole plant 2 37.40 11.79 21.92 342.07 10 28.92 28.70 28.60 565.22 50 22.42 34.08 34.19 795.70 100-2 Roots 2 35.68 15.00 21.66 332.08 10 29.42 24.87 32.67 497.75 50 22.23 35.45 37.28 761.52 100-3 Bark 2 34.22 19.98 22.29 271.65 10 28.40 28.81 32.32 512.88 50 21.34 36.18 38.12 786.49 100-4 Leaves 2 36.24 15.16 25.81 394.22 10 28.34 22.60 32.84 594.80 50 26.80 38.40 38.31 666.24 100-5 Fruits 2 35.39 12.36 20.30 311.67 10 28.50 25.61 28.00 538.32 50 26.18 35.49 35.37 686.63 100-6 Flowers 2 39.51 17.14 20.21 283.76 10 31.72 27.85 31.28 571.33 50 24.67 36.93 39.89 663.11

TABLE-US-00195 TABLE 195 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 100.sup.  Manchurian Ulmus laciniata Manchurian Elm (Trautv.) Mayr Elm Comparative Elm Ulmus Davidiana 3.36 MIC (%) Bacteria: 2/Fungi: 2 10.0 12.5 Example 100-1 Whole plant 0.13 MIC (%) Bacteria: 1/Fungi: 0.25 23.9 22.4 100-2 Roots 0.57 MIC (%) Bacteria: 0.5, Fungi: 1 24.6 10.3 100-3 Bark 0.11 MIC (%) Bacteria: 0.25, Fungi: 0.5 27.2 14.4 100-4 Leaves 0.31 MIC (%) Bacteria: 0.125, Fungi: 0.5 24.3 9.7 100-5 Fruits 0.47 MIC (%) Bacteria: 0.5, Fungi: 1 13.6 25.9 100-6 Flowers 0.23 MIC (%) Bacteria: 0.5, Fungi: 0.5 10.8 9.0

EXAMPLE 101

Montane Alder

[0201]

TABLE-US-00196 TABLE 196 Anti- Whitening Anti-wrinkle inflammation Moisturizing Conc. Melanin Collagen synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 101.sup.  Montane Alnus maximowiczii Montane alder Callier alder Comparative Alder 50 Alnus Japonica 86.85 11.44 1.53 99.99 Example 101-1 Whole plant 2 36.15 11.81 25.13 201.20 10 30.78 29.09 28.00 527.79 50 25.54 33.02 39.73 756.51 101-2 Roots 2 38.09 17.18 26.93 232.85 10 27.85 27.66 33.03 416.76 50 21.05 36.10 38.13 729.55 101-3 Bark 2 38.06 17.62 26.99 293.96 10 30.18 21.05 27.89 535.42 50 23.57 34.65 35.46 714.95 101-4 Leaves 2 35.60 18.66 23.31 373.69 10 27.17 24.03 32.07 444.84 50 25.40 36.27 39.45 794.32 101-5 Fruits 2 34.03 12.16 20.45 213.74 10 28.74 29.98 31.39 494.44 50 24.57 31.60 38.89 697.06 101-6 Flowers 2 37.63 17.92 21.49 392.35 10 28.07 22.45 30.62 576.90 50 24.77 33.12 35.26 776.92

TABLE-US-00197 TABLE 197 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 101.sup.  Montane Alnus maximowiczii Montane alder Callier alder Comparative Alder Alnus Japonica 5.45 MIC (%) Bacteria: 2/Fungi: >2 9.7 9.0 Example 101-1 Whole plant 0.42 MIC (%) Bacteria: 1/Fungi: >1 21.3 21.1 101-2 Roots 0.56 MIC (%) Bacteria: 1, Fungi: 2 22.3 17.3 101-3 Bark 0.11 MIC (%) Bacteria: 0.5, Fungi: 0.5 14.5 12.6 101-4 Leaves 0.93 MIC (%) Bacteria: 0.5, Fungi: 0.5 9.0 15.6 101-5 Fruits 0.27 MIC (%) Bacteria: 0.5, Fungi: 0.5 19.2 13.7 101-6 Flowers 0.98 MIC (%) Bacteria: 0.5, Fungi: 0.5 9.2 13.8

EXAMPLE 102

Ulleungdo Linden

[0202]

TABLE-US-00198 TABLE 198 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 102.sup.  Ulleungdo Tilia insularis Ulleungdo linden Nakai linden Comparative Tilia 50 Tilia Platyphyllos 88.59 10.96 1.39 67.41 Example platyphyllos 102-1 Whole plant 2 39.10 11.25 24.49 398.99 10 30.96 23.70 31.39 453.96 50 25.10 37.13 36.31 721.43 102-2 Roots 2 39.69 10.55 23.25 210.52 10 30.50 23.83 29.14 564.69 50 20.89 31.77 34.57 634.88 102-3 Bark 2 39.99 16.33 20.41 352.24 10 28.37 20.27 28.64 600.03 50 24.21 36.56 37.75 773.90 102-4 Leaves 2 37.89 18.59 23.35 314.05 10 33.19 24.28 29.92 544.36 50 20.21 37.37 35.80 706.82 102-5 Fruits 2 37.84 14.98 26.22 318.06 10 28.67 29.62 32.02 524.65 50 21.74 35.14 38.14 651.34 102-6 Flowers 2 39.95 13.32 26.32 237.92 10 31.13 25.30 32.67 406.62 50 20.39 39.28 36.28 695.66

TABLE-US-00199 TABLE 199 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 102.sup.  Ulleungdo Tilia insularis Ulleungdo linden Nakai linden Comparative Tilia platyphyllos Tilia Platyphyllos 6.89 MIC (%) Bacteria: >2/Fungi: >2 9.1 9.1 Example 102-1 Whole plant 0.38 MIC (%) Bacteria: 1/Fungi: 0.1 24.2 17.1 102-2 Roots 0.99 MIC (%) Bacteria: 0.5, Fungi: 0.5 20.6 15.0 102-3 Bark 0.11 MIC (%) Bacteria: 0.25, Fungi: 27.8 16.2 0.25 102-4 Leaves 0.61 MIC (%) Bacteria: 2, Fungi: 1 22.1 15.2 102-5 Fruits 0.44 MIC (%) Bacteria: 1, Fungi: 1 10.1 20.8 102-6 Flowers 0.64 MIC (%) Bacteria: 1, Fungi: 0.5 11.0 16.2

EXAMPLE 103

Fragrant Snowbell

[0203]

TABLE-US-00200 TABLE 200 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 103.sup.  Fragrant Styrax obassia Fragrant snowbell Siebold & Zucc. snowbell Comparative Snowbell 50 Styrax Japonicus 79.41 7.60 2.53 49.00 Example 103-1 Whole plant 2 37.01 15.55 22.12 288.43 10 31.11 21.88 31.11 414.74 50 25.80 39.66 35.98 682.20 103-2 Roots 2 39.75 17.72 25.19 252.28 10 29.85 20.81 28.73 537.45 50 22.85 35.06 34.12 776.64 103-3 Bark 2 34.89 11.61 22.20 225.88 10 28.74 24.52 27.15 445.90 50 21.30 30.36 38.71 712.19 103-4 Leaves 2 34.34 15.44 25.62 209.60 10 27.26 21.02 29.95 408.02 50 26.06 38.74 36.41 660.65 103-5 Fruits 2 34.09 18.90 26.84 323.54 10 32.38 25.94 27.10 428.97 50 23.06 35.56 35.85 700.60 103-6 Flowers 2 36.76 17.54 25.95 215.69 10 29.39 21.67 32.73 540.52 50 22.29 37.53 38.29 614.62

TABLE-US-00201 TABLE 201 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 103.sup.  Fragrant Styrax obassia Fragrant snowbell Siebold & Zucc. snowbell Comparative Snowbell Styrax Japonicus 4.75 MIC (%) Bacteria: >2/Fungi: 2 9.9 8.1 Example 103-1 Whole plant 0.49 MIC (%) Bacteria: 0.5/Fungi: 0.25 26.4 22.2 103-2 Roots 0.28 MIC (%) Bacteria: 1, Fungi: 0.5 14.5 17.7 103-3 Bark 0.13 MIC (%) Bacteria: 0.25, Fungi: 0.25 13.2 26.0 103-4 Leaves 0.08 MIC (%) Bacteria: 1, Fungi: 1 13.6 19.4 103-5 Fruits 0.28 MIC (%) Bacteria: 0.5, Fungi: 1 21.1 20.1 103-6 Flowers 0.27 MIC (%) Bacteria: 0.25, Fungi: 0.5 19.3 8.1

EXAMPLE 104

Ulleungdo Flowering Cherry

[0204]

TABLE-US-00202 TABLE 202 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 104.sup.  Ulleungdo Prunus takesimensis Ulleungdo flowering Nakai flowering cherry cherry Comparative Cherry 50 Prunus Serrulata 99.63 10.15 5.39 18.71 Example 104-1 Whole plant 2 35.79 11.44 23.61 207.78 10 32.33 28.52 30.76 509.66 50 26.35 38.60 37.11 718.73 104-2 Roots 2 36.59 19.56 23.06 380.77 10 27.29 29.11 27.41 576.88 50 25.88 36.94 39.25 763.51 104-3 Bark 2 38.49 12.70 22.00 284.99 10 27.98 25.29 31.49 474.81 50 24.42 35.17 38.09 749.06 104-4 Leaves 2 35.30 16.76 24.78 296.96 10 28.54 21.58 29.62 463.07 50 25.05 30.71 37.94 603.53 104-5 Fruits 2 35.26 10.24 22.71 346.40 10 32.64 28.83 27.84 504.72 50 25.05 31.19 38.51 609.45 104-6 Flowers 2 37.00 19.84 26.65 242.91 10 32.67 29.00 29.93 404.07 50 25.62 37.97 39.46 618.80

TABLE-US-00203 TABLE 203 Anti-bacteria Anti-bacteria Anti- (S. mutans) (P. gingivalis) oxidation Size of growth Size of growth IC50 Anti-bacteria inhibition ring inhibition ring No. Sample Scientific name English name (%) MIC (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 104.sup.  Ulleungdo Prunus takesimensis Ulleungdo flowering Nakai flowering cherry cherry Comparative Cherry Prunus Serrulata 3.84 MIC (%) Bacteria: >2/Fungi: 2 7.5 8.1 Example 104-1 Whole plant 0.33 MIC (%) Bacteria: 2/Fungi: 1 17.7 20.3 104-2 Roots 0.47 MIC (%) Bacteria: 1, Fungi: 0.5 11.1 23.2 104-3 Bark 0.29 MIC (%) Bacteria: 0.5, Fungi: 1 27.8 27.5 104-4 Leaves 0.55 MIC (%) Bacteria: 0.5, Fungi: 0.5 18.2 12.6 104-5 Fruits 0.81 MIC (%) Bacteria: 0.5, Fungi: 1 9.3 17.9 104-6 Flowers 0.81 MIC (%) Bacteria: 1, Fungi: 1 22.8 19.7

EXAMPLE 105

Spotted Laurel

[0205]

TABLE-US-00204 TABLE 204 Anti-wrinkle Anti- Whitening Collagen inflammation Moisturizing Conc. Melanin synthesis Inhibition of NO HA synthesis No. Sample (ppm) Scientific name English name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 105.sup.  Spotted Aucuba japonica Spotted laurel Thuhb. laurel 105-1 Whole plant 2 39.64 15.21 22.34 273.76 10 31.64 23.72 30.09 410.28 50 24.40 32.38 37.77 789.10 105-2 Roots 2 37.16 13.30 20.63 376.67 10 31.48 20.44 33.14 598.31 50 23.66 33.89 35.43 712.28 105-3 Branches 2 38.57 10.31 26.62 388.96 10 29.95 22.80 33.16 439.07 50 26.72 39.65 39.80 640.36 105-4 Leaves 2 35.68 12.87 24.13 212.51 10 33.35 22.21 29.26 417.65 50 30.67 29.95 30.31 497.93 105-5 Fruits 2 35.68 18.86 23.26 269.96 10 28.89 28.44 28.51 581.54 50 24.57 31.93 39.97 713.21 105-6 Flowers 2 36.10 19.67 24.71 288.20 10 31.88 24.37 31.40 412.19 50 22.71 33.17 38.22 695.99 105-7 Bark 2 36.59 13.12 20.94 336.04 10 28.13 27.91 30.47 400.45 50 24.45 35.35 36.99 632.79

TABLE-US-00205 TABLE 205 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Scientific English IC50 MIC inhibition ring inhibition ring No. Sample name name (%) (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 105 Spotted laurel Aucuba japonica Spotted laurel Thunb. 105-1 Whole plant 0.11 MIC (%) Bacteria, Fungi: 1 13.6 18.0 105-2 Roots 0.93 MIC (%) Bacteria: 0.125 9.1 14.2 MIC (%) Fungi: 0.25 105-3 Branches 0.48 MIC (%) Bacteria: 0.5 26.0 19.8 MIC (%) Fungi: 1 105-4 Leaves 0.46 MIC (%) Bacteria: 0.5 14.1 13.6 MIC (%) Fungi: 0.25 105-5 Fruits 0.35 MIC (%) Bacteria: 0.25 20.4 17.4 MIC (%) Fungi: 0.5 105-6 Flowers 0.49 MIC (%) Bacteria: 0.25 25.6 24.3 MIC (%) Fungi: 0.5 105-7 Bark 0.98 MIC (%) Bacteria: 0.25 12.3 13.9 MIC (%) Fungi: 0.25

EXAMPLE 106

Ulleungdo Maple

[0206]

TABLE-US-00206 TABLE 206 Anti- Anti- wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 106 Ulleungdo maple Acer takesimense Ulleungdo maple Nakai Comparative Sugar maple 50 Acer Saccharum 71.27 12.68 2.19 19.05 Example 106-1 Whole plant 2 38.99 11.59 21.36 298.74 10 31.52 26.39 28.12 547.10 50 20.19 32.75 37.03 732.59 106-2 Roots 2 34.18 19.32 24.03 351.47 10 28.21 22.74 30.26 455.80 50 25.99 33.55 35.24 639.76 106-3 Branches 2 36.35 12.68 24.34 227.74 10 33.94 24.85 29.90 330.35 50 29.72 28.21 31.91 408.04 106-4 Leaves 2 39.02 19.15 22.26 300.30 10 31.01 25.33 29.01 349.48 50 29.58 29.26 31.54 416.72 106-5 Fruits 2 34.59 14.63 21.29 320.67 10 28.37 24.03 31.29 406.24 50 23.57 36.54 39.14 624.71 106-6 Flowers 2 35.29 13.06 21.50 341.37 10 29.64 25.31 30.62 491.50 50 22.21 33.26 38.36 773.46

TABLE-US-00207 TABLE 207 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Scientific English IC50 MIC inhibition ring inhibition ring No. Sample name name (%) (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 106 Ulleungdo maple Acer takesimense Ulleungdo maple Nakai Comparative Sugar maple Acer Saccharum 5.31 MIC (%) Bacteria, Fungi: 2 9.3 8.0 Example 106-1 Whole plant 0.82 MIC (%) Bacteria, Fungi: 1 26.2 24.1 106-2 Roots 1.00 MIC (%) Bacteria: 0.25 12.7 26.1 MIC (%) Fungi: 0.5 106-3 Branches 1.83 MIC (%) Bacteria, Fungi: 1 27.4 22.8 106-4 Leaves 1.27 MIC (%) Bacteria: 0.5 17.7 24.9 MIC (%) Fungi: 0.5 106-5 Fruits 0.95 MIC (%) Bacteria: 0.25 25.3 11.7 MIC (%) Fungi: 0.5 106-6 Flowers 0.72 MIC (%) Bacteria: 0.0625 12.2 28.0 MIC (%) Fungi: 0.25

EXAMPLE 107

Ulleungdo Amur Corktree

[0207]

TABLE-US-00208 TABLE 208 Anti- Anti- wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control Arbutin TGFb L-NMMA EGF group (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 107 Ulleungdo amur Phellodendron insulare Ulleungdo amur corktree Nakai corktree Comparative Amur corktree 50 Phellodendron Amurense 95.46 7.52 4.90 12.35 Example 107-1 Whole plant 2 36.21 11.26 25.61 213.48 10 32.22 26.42 29.32 542.64 50 24.09 33.58 36.06 790.98 107-2 Roots 2 37.81 18.08 21.10 256.00 10 27.35 23.32 33.18 493.63 50 23.36 30.76 35.89 686.78 107-3 Branches 2 34.52 12.55 21.36 379.64 10 29.00 21.94 32.63 549.60 50 26.37 39.14 39.79 768.09 107-4 Leaves 2 36.18 13.72 22.95 363.10 10 33.04 24.56 27.87 407.06 50 26.91 32.02 39.84 740.31 107-5 Fruits 2 36.43 12.55 24.92 314.53 10 31.37 24.49 30.14 561.29 50 23.32 38.13 38.13 605.19 107-6 Flowers 2 36.70 12.52 24.48 222.05 10 28.53 20.07 33.08 439.11 50 21.96 39.45 39.83 629.91 107-7 Bark 2 35.19 19.92 21.68 346.36 10 28.75 22.89 32.02 450.53 50 25.68 38.69 37.92 641.66

TABLE-US-00209 TABLE 209 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Scientific English IC50 MIC inhibition ring inhibition ring No. Sample name name (%) (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 107 Ulleungdo Phellodendron insulare Ulleungdo amur Nakai amur corktree corktree Comparative Amur corktree Phellodendron Amurense 9.49 MIC (%) Bacteria, 8.8 14.1 Example Fungi: >2 107-1 Whole plant 0.40 MIC (%) Bacteria, 25.2 26.2 Fungi: 1 107-2 Roots 0.85 MIC (%) Bacteria: 1 18.4 15.0 MIC (%) Fungi: 0.5 107-3 Branches 0.50 MIC (%) Bacteria, 13.9 18.7 Fungi: 0.25 107-4 Leaves 0.91 MIC (%) Bacteria: 1 10.8 10.3 MIC (%) Fungi: 0.25 107-5 Fruits 0.19 MIC (%) Bacteria: 0.5 22.3 24.2 MIC (%) Fungi: 0.5 107-6 Flowers 0.66 MIC (%) Bacteria: 0.25 12.4 15.8 MIC (%) Fungi: 0.125 107-7 Bark 0.36 MIC (%) Bacteria: 0.125 24.7 17.6 MIC (%) Fungi: 0.125

EXAMPLE 108

Alianthus-Like Prickly-Ash

[0208]

TABLE-US-00210 TABLE 210 Anti- Anti- wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 108 Alianthus-like Zanthoxylum ailanthoides Alianthus-like prickly-ash Siebold & Zucc. prickly-ash Comparative Cho-phi 50 Zanthoxylum Piperitum 86.23 10.33 6.74 92.82 Example 108-1 Whole plant 2 34.07 18.82 20.14 229.40 10 28.11 20.82 29.93 514.20 50 25.24 36.35 36.16 615.72 108-2 Roots 2 36.14 10.71 20.25 298.23 10 33.81 27.12 30.62 539.30 50 25.19 36.45 34.48 769.41 108-3 Branches 2 37.88 14.41 26.97 287.35 10 30.19 22.34 28.86 520.68 50 29.15 30.56 31.56 604.11 108-4 Leaves 2 35.53 17.55 23.49 292.04 10 33.87 24.79 25.86 454.73 50 31.35 28.61 29.12 633.49 108-5 Fruits 2 39.88 17.82 20.34 297.85 10 28.33 23.87 29.42 576.34 50 23.29 33.08 35.91 773.14 108-6 Flowers 2 39.93 13.44 26.07 355.02 10 29.54 25.50 32.43 521.58 50 26.55 38.51 36.94 677.79 108-7 Seeds 2 35.64 19.94 23.94 268.99 10 33.03 21.34 28.26 472.02 50 24.05 39.59 36.72 781.94 108-8 Bark 2 36.33 11.04 20.18 207.81 10 33.37 27.91 30.02 445.54 50 27.00 37.35 34.79 654.11

TABLE-US-00211 TABLE 211 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Scientific English IC50 MIC inhibition ring inhibition ring No. Sample name name (%) (%) (mm) (mm) Control Vitamin C Hexanediol Untreated Untreated group 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 108 Alianthus- Zanthoxylum ailanthoides Alianthus-like like Siebold & Zucc. prickly-ash prickly- ash Comparative Cho-phi Zanthoxylum Piperitum 7.29 MIC (%) Bacteria, 7.9 16.7 Example Fungi: 2 108-1 Whole plant 0.76 MIC (%) Bacteria, 18.4 26.0 Fungi: 1 108-2 Roots 0.39 MIC (%) Bacteria, 27.1 16.4 Fungi: 0.5 108-3 Branches 1.75 MIC (%) Bacteria, 10.8 14.2 Fungi: 1 108-4 Leaves 2.44 MIC (%) Bacteria: 1 14.7 10.1 MIC (%) Fungi: 0.5 108-5 Fruits 0.84 MIC (%) Bacteria: 0.25 22.3 14.0 MIC (%) Fungi: 1 108-6 Flowers 0.68 MIC (%) Bacteria: 1 14.9 22.8 MIC (%) Fungi: 1 108-7 Seeds 0.20 MIC (%) Bacteria, 13.6 21.6 Fungi: 0.25 108-8 Bark 0.95 MIC (%) Bacteria: 0.5 18.0 10.7 MIC (%) Fungi: 1

EXAMPLE 109

Wax-Leaf Privet

[0209]

TABLE-US-00212 TABLE 212 Anti- Anti- wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 109 Wax-leaf privet Ligustrum japonicum Wax-leaf privet Thunb. Comparative Glossy privet 50 Ligustrum Lucidum 75.54 9.32 2.08 146.89 Example 109-1 Whole plant 2 39.15 16.98 26.34 252.56 10 28.36 21.48 31.84 473.52 50 25.35 35.16 38.39 698.45 109-2 Roots 2 35.28 10.69 24.53 385.25 10 31.46 20.51 32.66 599.04 50 22.21 39.76 39.22 701.91 109-3 Branches 2 36.02 17.04 25.00 286.29 10 32.02 28.13 27.89 362.60 50 29.32 31.05 30.86 367.03 109-4 Leaves 2 39.73 18.07 20.27 248.62 10 29.35 21.77 28.79 368.58 50 27.07 33.98 31.17 400.16 109-5 Fruits 2 35.82 11.47 23.06 222.74 10 30.04 29.77 28.51 381.79 50 28.18 34.53 29.66 499.06 109-6 Flowers 2 37.69 11.78 21.85 297.17 10 30.13 22.99 32.02 517.25 50 26.89 32.74 36.31 671.19 109-7 Bark 2 39.21 16.32 22.70 223.82 10 31.71 27.19 32.03 463.23 50 24.35 39.40 38.74 772.54

TABLE-US-00213 TABLE 213 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Scientific English IC50 MIC inhibition ring inhibition ring No. Sample name name (%) (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 109 Wax-leaf privet Ligustrum japonicum Wax-leaf Thunb. privet Comparative Glossy privet Ligustrum Lucidum 9.93 MIC (%) Bacteria, Fungi: 2 12.4 12.4 Example 109-1 Whole plant 0.95 MIC (%) Bacteria, Fungi: 0.25 27.4 20.5 109-2 Roots 0.18 MIC (%) Bacteria, Fungi: 0.5 13.1 24.0 109-3 Branches 1.61 MIC (%) Bacteria, Fungi: 0.5 24.3 26.1 109-4 Leaves 3.25 MIC (%) Bacteria: 1 15.8 10.2 MIC (%) Fungi: 0.5 109-5 Fruits 2.97 MIC (%) Bacteria: 0.5 13.6 16.2 MIC (%) Fungi: 1 109-6 Flowers 0.80 MIC (%) Bacteria: 0.25 19.0 10.7 MIC (%) Fungi: 0.5 109-7 Bark 0.72 MIC (%) Bacteria: 0.5 12.4 13.8 MIC (%) Fungi: 0.5

EXAMPLE 110

Ulleungdo Honeysuckle

[0210]

TABLE-US-00214 TABLE 214 Anti- Anti- wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 110 Ulleungdo Lonicera insularis Ulleungdo honeysuckle Nakai honeysuckle Comparative Honeysuckle 50 Lonicera Japonica 75.89 11.16 3.22 160.43 Example 110-1 Whole plant 2 39.45 19.66 22.49 203.11 10 30.32 27.20 29.15 458.35 50 21.23 38.68 38.75 791.32 110-2 Roots 2 38.29 15.41 24.93 329.43 10 30.53 23.61 29.61 563.95 50 26.48 30.08 38.64 663.80 110-3 Stems 2 34.56 18.25 20.92 298.21 10 30.62 27.04 23.00 582.05 50 24.07 31.43 28.76 790.17 110-4 Leaves 2 36.54 10.66 20.24 237.84 10 30.81 25.12 23.78 540.34 50 23.46 30.54 25.99 630.55 110-5 Fruits 2 36.97 10.00 24.92 387.60 10 27.55 28.91 28.74 580.23 50 22.45 31.51 38.59 730.80 110-6 Flowers 2 37.13 14.80 25.70 200.96 10 31.71 27.18 28.66 550.48 50 26.18 35.05 35.65 610.62

TABLE-US-00215 TABLE 215 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Scientific English IC50 MIC inhibition ring inhibition ring No. Sample name name (%) (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 110 Ulleungdo Lonicera insularis Ulleungdo honevsuckle Nakai honevsuckle Comparative Honeysuckle Lonicera Japonica 7.46 MIC (%) Bacteria: 2, Fungi: >2 12.6 9.9 Example 110-1 Whole plant 0.14 MIC (%) Bacteria, Fungi: 1 21.5 24.1 110-2 Roots 0.94 MIC (%) Bacteria, Fungi: 0.5 14.9 14.2 110-3 Stems 0.70 MIC (%) Bacteria, Fungi: 1 16.0 16.9 110-4 Leaves 0.76 MIC (%) Bacteria: 0.5 21.3 13.7 MIC (%) Fungi: 0.25 110-5 Fruits 0.67 MIC (%) Bacteria: 0.25 22.1 11.0 MIC (%) Fungi: 0.25 110-6 Flowers 0.22 MIC (%) Bacteria: 0.125 26.9 25.3 MIC (%) Fungi: 0.125

EXAMPLE 111

Silk Tree

[0211]

TABLE-US-00216 TABLE 216 Anti- Anti- wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 111 Silk tree Albizia julibrissin Silk tree Comparative Kalkora mimosa 50 Albizia Kalkora 44.21 17.03 18.50 154.13 Example 111-1 Whole plant 2 37.84 14.95 21.43 299.79 10 28.10 24.41 31.87 489.87 50 24.22 31.72 36.88 571.19 111-2 Bark 2 36.86 14.07 25.96 323.19 10 29.37 26.71 29.75 559.16 50 21.52 37.31 38.13 781.23 111-3 Roots 2 37.39 12.04 24.08 172.51 10 27.19 29.77 27.88 304.79 50 21.36 34.10 34.17 529.62 111-4 Branches 2 36.73 17.61 23.95 359.01 10 29.89 22.79 29.04 448.22 50 23.17 37.59 36.89 639.13 111-5 Leaves 2 38.97 11.87 22.80 272.97 10 31.85 26.07 28.66 438.82 50 26.92 39.68 34.15 531.88 111-6 Fruits 2 34.22 11.30 20.14 293.65 10 27.95 26.45 30.04 377.80 50 25.25 32.53 36.09 556.30 111-7 Flowers 2 37.28 14.98 22.81 313.98 10 29.21 22.13 30.34 452.83 50 23.28 32.85 35.80 610.68

TABLE-US-00217 TABLE 217 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Conc. Scientific English IC50 MIC inhibition ring inhibition ring No. Sample (ppm) name name (%) (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 111 Silk tree Albizia julibrissin Silk tree Comparative Kalkora mimosa 50 Albizia Kalkora 1.41 MIC (%) Bacteria: 2 3.5 2.5 Example MIC (%) Fungi: 2 111-1 Whole plant 2 0.70 MIC (%) Bacteria: 0.5 11.8 12.4 10 MIC (%) Fungi: 0.5 50 111-2 Bark 2 0.11 MIC (%) Bacteria: 0.125 24.3 15.0 10 MIC (%) Fungi: 0.125 50 111-3 Roots 2 0.91 MIC (%) Bacteria: 0.5 2.7 7.1 10 MIC (%) Fungi: 0.5 50 111-4 Branches 2 0.83 MIC (%) Bacteria: 0.25 12.7 8.3 10 MIC (%) Fungi: 0.25 50 111-5 Leaves 2 0.56 MIC (%) Bacteria: 0.5 2.3 1.3 10 MIC (%) Fungi: 0.5 50 111-6 Fruits 2 0.23 MIC (%) Bacteria: 0.5 1.8 7.4 10 MIC (%) Fungi: 0.5 50 111-7 Flowers 2 0.03 MIC (%) Bacteria: 0.125 14.6 10.1 10 MIC (%) Fungi: 0.125 50

EXAMPLE 112

False Daisy

[0212]

TABLE-US-00218 TABLE 218 Anti- Anti- wrinkle inflammation Whitening Collagen Inhibition Moisturizing Conc. Scientific English Melanin synthesis of NO HA synthesis No. Sample (ppm) name name content (%) (% of control) production (%) (%) Control group Arbutin TGFb L-NMMA EGF (200 ppm) (10 ppb) (5 ppm) (10 ppb) 35% 25% 28% 320% 112 False daisy Eclipta prostrata False daisy Comparative Fine-leaf false 50 Eclipta alba 46.81 11.72 4.23 251.26 Example daisy 112-1 Whole plant 2 39.38 18.50 23.27 238.97 10 33.95 21.62 29.69 507.30 50 25.45 37.67 38.31 759.48 112-2 Roots 2 34.77 15.67 24.38 231.64 10 31.99 26.87 29.45 342.45 50 24.79 35.72 36.18 348.54 112-3 Stems 2 35.32 19.67 25.11 192.98 10 31.00 28.08 33.32 264.29 50 21.57 33.85 36.97 369.80 112-4 Leaves 2 37.40 12.60 21.76 250.14 10 30.94 27.11 32.47 257.05 50 20.55 31.82 38.45 319.48 112-5 Fruits 2 34.68 12.36 24.31 151.18 10 30.40 26.89 32.84 207.81 50 20.16 34.15 34.99 285.57 112-6 Flowers 2 39.65 11.97 26.69 198.64 10 33.64 29.37 29.90 314.58 50 22.37 30.00 34.02 559.51

TABLE-US-00219 TABLE 219 Anti-bacteria Anti-bacteria Anti- Anti- (S. mutans) (P. gingivalis) oxidation bacteria Size of growth Size of growth Conc. Scientific English IC50 MIC inhibition ring inhibition ring No. Sample (ppm) name name (%) (%) (mm) (mm) Control group Vitamin C Hexanediol Untreated Untreated 7.5 ppm Bacteria: P. aeruginosa 2% 0 mm 0 mm Fungi: A. niger 1% 112 False daisy Eclipta prostrata False daisy Comparative Fine-leaf false 50 Eclipta alba 1.85 MIC (%) Bacteria: 1 1.9 2.3 Example daisy MIC (%) Fungi: 2 112-1 Whole plant 2 0.17 MIC (%) Bacteria: 0.125 18.0 24.7 10 MIC (%) Fungi: 0.125 50 112-2 Roots 2 0.69 MIC (%) Bacteria: 1 6.2 3.3 10 MIC (%) Fungi: 1 50 112-3 Stems 2 0.73 MIC (%) Bacteria: 1 7.4 2.0 10 MIC (%) Fungi: 1 50 112-4 Leaves 2 0.99 MIC (%) Bacteria: 0.25 3.9 7.8 10 MIC (%) Fungi: 0.5 50 112-5 Fruits 2 0.24 MIC (%) Bacteria: 0.5 4.4 3.2 10 MIC (%) Fungi: 0.5 50 112-6 Flowers 2 0.09 MIC (%) Bacteria: 0.25 14.1 10.3 10 MIC (%) Fungi: 0.25 50

FORMULATION EXAMPLE 1

Preparation of Pharmaceutical Preparations

[0213] 1. Preparation of powder

[0214] 0.001 g of plant extracts

[0215] 1 g of lactose

[0216] The above ingredients were mixed, and a sealable bag was filled with the mixed ingredients to prepare powder.

[0217] 2. Preparation of tablets

[0218] 0.2 mg of plant extracts

[0219] 100 mg of corn starch

[0220] 100 mg of lactose

[0221] 2 mg of magnesium stearate

[0222] After mixing the above ingredients, tableting was performed according to a conventional tablet preparation method to prepare tablets.

[0223] 3. Preparation of capsules

[0224] 0.2 mg of plant extracts

[0225] 100 mg of corn starch

[0226] 100 mg of lactose

[0227] 2 mg of magnesium stearate

[0228] After mixing the above ingredients, gelatin capsules were filled with the mixed ingredients according to a conventional capsule preparation method to prepare capsules.

[0229] 4. Preparation of pills

[0230] 0.003 g of plant extracts

[0231] 1.5 g of lactose

[0232] 1 g of glycerin

[0233] 0.5 g of xylitol

[0234] After mixing the above ingredients, according to a conventional method, pills were prepared so that the weight of one pill was 4 g.

[0235] 5. Preparation of granules

[0236] 2 mg of plant extracts

[0237] 50 mg of soybean extracts

[0238] 200 mg of glucose

[0239] 600 mg of starch

[0240] After mixing the above ingredients, 100 mg of 30% ethanol was added thereto, and drying was performed at 60° C. to form granules. Then, a capsule was filled with the granules.

FORMULATION EXAMPLE 2

Preparation of Cosmetics

[0241] 1. Preparation of softening lotion (skin lotion)

[0242] According to the following composition, a softening lotion containing plant extracts as active ingredients was prepared according to a conventional method.

[0243] 0.1% by weight of plant extracts

[0244] 1.0% by weight of beta-1,3-glucan

[0245] 2.0% by weight of butylene glycol

[0246] 2.0% by weight of propylene glycol

[0247] 0.1% by weight of a carboxyvinyl polymer

[0248] 0.2% by weight of PEG-12 nonylphenyl ether

[0249] 0.4% by weight of polysorbate 80

[0250] 10.0% by weight of ethanol

[0251] 0.1% by weight of triethanolamine

[0252] 0.05% by weight of a preservative

[0253] 0.05% by weight of a pigment

[0254] 0.05% by weight of a perfume

[0255] Purified water: Up to 100% by weight

[0256] 2. Preparation of nourishing lotion (milk lotion)

[0257] According to the following composition, a nourishing lotion containing plant extracts as active ingredients was prepared according to a conventional method.

[0258] 0.1% by weight of plant extracts

[0259] 1.0% by weight of beta-1,3-glucan

[0260] 4.0% by weight of beeswax

[0261] 1.5% by weight of polysorbate 60

[0262] 1.5% by weight of sorbitan sesquioleate

[0263] 0.5% by weight of liquid paraffin

[0264] 5.0% by weight of caprylic/capric triglyceride

[0265] 3.0% by weight of glycerin

[0266] 3.0% by weight of butylene glycol

[0267] 3.0% by weight of propylene glycol

[0268] 0.1% by weight of a carboxyvinyl polymer

[0269] 0.2% by weight of triethanolamine

[0270] 0.05% by weight of a preservative

[0271] 0.05% by weight of a pigment

[0272] 0.05% by weight of a perfume

[0273] Purified water: Up to 100% by weight

[0274] 3. Preparation of nourishing cream

[0275] According to the following composition, a nourishing cream containing plant extracts as active ingredients was prepared according to a conventional method.

[0276] 0.2% by weight of plant extracts

[0277] 5.0% by weight of beta-1,3-glucan

[0278] 10.0% by weight of beeswax

[0279] 1.5% by weight of polysorbate 60

[0280] 2.0% by weight of PEG 60 hydrogenated castor oil

[0281] 0.5% by weight of sorbitan sesquioleate

[0282] 10.0% by weight of liquid paraffin

[0283] 5.0% by weight of squalene

[0284] 5.0% by weight of caprylic/capric triglyceride

[0285] 5.0% by weight of glycerin

[0286] 3.0% by weight of butylene glycol

[0287] 3.0% by weight of propylene glycol

[0288] 0.2% by weight of triethanolamine

[0289] 0.05% by weight of a preservative

[0290] 0.05% by weight of a pigment

[0291] 0.05% by weight of a perfume

[0292] Purified water: Up to 100% by weight

[0293] 4. Preparation of massage cream

[0294] According to the following composition, a massage cream containing plant extracts as active ingredients was prepared according to a conventional method.

[0295] 0.1% by weight of plant extracts

[0296] 3.0% by weight of beta-1,3-glucan

[0297] 10.0% by weight of beeswax

[0298] 1.5% by weight of polysorbate 60

[0299] 2.0% by weight of PEG 60 hydrogenated castor oil

[0300] 0.8% by weight of sorbitan sesquioleate

[0301] 40.0% by weight of liquid paraffin

[0302] 5.0% by weight of squalene

[0303] 4.0% by weight of caprylic/capric triglyceride

[0304] 5.0% by weight of glycerin

[0305] 3.0% by weight of butylene glycol

[0306] 3.0% by weight of propylene glycol

[0307] 0.2% by weight of triethanolamine

[0308] 0.05% by weight of a preservative

[0309] 0.05% by weight of a pigment

[0310] 0.05% by weight of a perfume

[0311] Purified water: Up to 100% by weight

[0312] 5. Preparation of pack

[0313] According to the following composition, a pack containing plant extracts as active ingredients was prepared according to a conventional method.

[0314] 0.2% by weight of plant extracts

[0315] 1.0% by weight of beta-1,3-glucan

[0316] 13.0% by weight of polyvinyl alcohol

[0317] 0.2% by weight of sodium carboxymethyl cellulose

[0318] 5.0% by weight of glycerin

[0319] 0.1% by weight of allantoin

[0320] 6.0% by weight of ethanol

[0321] 0.3% by weight of PEG -12 nonylphenyl ether

[0322] 0.3% by weight of polysorbate 60

[0323] 0.05% by weight of a preservative

[0324] 0.05% by weight of a pigment

[0325] 0.05% by weight of a perfume

[0326] Purified water: Up to 100% by weight

FORMULATION EXAMPLE 3

Preparation of Skin External Preparation

[0327] 1. Preparation of gel

[0328] According to the following composition, a gel containing plant extracts as active ingredients was prepared according to a conventional method.

[0329] 0.1% by weight of plant extracts

[0330] 0.1% by weight of beta-1,3-glucan

[0331] 0.05% by weight of sodium ethylenediamine acetate

[0332] 5.0% by weight of glycerin

[0333] 0.3% by weight of a carboxyvinyl polymer

[0334] 5.0% by weight of ethanol

[0335] 0.5% by weight of PEG-60 hydrogenated castor oil

[0336] 0.3% by weight of triethanolamine

[0337] 0.05% by weight of a preservative

[0338] 0.05% by weight of a pigment

[0339] 0.05% by weight of a perfume

[0340] Purified water: Up to 100% by weight

[0341] 2. Preparation of ointment

[0342] According to the following composition, an ointment containing plant extracts as active ingredients was prepared according to a conventional method.

[0343] 0.5% by weight of plant extracts

[0344] 10.0% by weight of beta-1,3-glucan

[0345] 10.0% by weight of beeswax

[0346] 5.0% by weight of polysorbate 60

[0347] 2.0% by weight of PEG 60 hydrogenated castor oil

[0348] 0.5% by weight of sorbitan sesquioleate

[0349] 5.0% by weight of Vaseline

[0350] 10.0% by weight of liquid paraffin

[0351] 5.0% by weight of squalene

[0352] 3.0% by weight of shea butter

[0353] 5.0% by weight of caprylic/capric triglyceride

[0354] 10.0% by weight of glycerin

[0355] 10.2% by weight of propylene glycol

[0356] 0.2% by weight of triethanolamine

[0357] 0.05% by weight of a preservative

[0358] 0.05% by weight of a pigment

[0359] 0.05% by weight of a perfume

[0360] water: Up to 100% by weight

[0361] 3. Preparation of drug for topical administration (gel ointment)

[0362] According to the following composition, a gel ointment containing plant extracts as active ingredients was prepared according to a conventional method.

[0363] 0.5% by weight of plant extracts

[0364] 10.0% by weight of beta-1,3-glucan

[0365] 1.5% by weight of polyacrylic acid (Carbopol 940)

[0366] 5.0% by weight of isopropanol

[0367] 25.0% by weight of hexylene glycol

[0368] 1.7% by weight of triethanolamine

[0369] Deionized water: Up to 100% by weight

[0370] 4. Preparation of drug for topical administration (patch)

[0371] According to the following composition, a patch containing plant extracts as active ingredients was prepared according to a conventional method.

[0372] 0.5% by weight of plant extracts

[0373] 3.0% by weight of beta-1,3-glucan

[0374] 20.0% by weight of hexylene glycol

[0375] 0.7% by weight of diethylamine

[0376] 1.0% by weight of polyacrylic acid (Carbopol 934P)

[0377] 0.1% by weight of sodium sulfite

[0378] 1.0% by weight of polyoxyethylene lauryl ether (E.O=9)

[0379] 1.0% by weight of polyhydroxyethylene cetyl stearyl ether (Cetomacrogol 1000)

[0380] 2.5% by weight of viscous paraffin oil

[0381] 2.5% by weight of caprylic acid ester/capric acid ester (Cetiol LC)

[0382] 3.0% by weight of polyethylene glycol 400

[0383] Deionized water: Up to 100% by weight

FORMULATION EXAMPLE 4

Manufacture of Food

[0384] Foods containing the plant extracts of the present invention were prepared as follows.

[0385] 1. Manufacture of flour food

[0386] 0.05 to 1.0 part by weight of the plant extracts was added to flour to prepare a mixture. This mixture was used to manufacture health foods such as breads, cakes, cookies, crackers, and noodles.

[0387] 2. Manufacture of dairy products

[0388] 0.2 parts by weight of the plant extracts was added to milk, and various dairy products such as butter and ice cream were manufactured using the milk.

[0389] 3. Manufacture of mixed grain powder

[0390] Brown rice, barley, glutinous rice, and adlay were dried through pregelatinization by a known method, and then the dried grains were roasted and pulverized using a grinder to obtain powder having a particle size of 60 mesh, In addition, black beans, black sesame, and perilla were steamed and dried according to a known method. Then, the dried grains were roasted and pulverized using a grinder to obtain powder having a particle size of 60 mesh. The plant extracts were concentrated under reduced pressure using a vacuum concentrator and dried through spraying and hot air drying to obtain a dried product. The dried product was pulverized using a grinder to obtain powder having a particle size of 60 mesh,

[0391] Based on 100 parts by weight of the mixed powder, the dry powder of grains, seeds, and plant extracts prepared above was blended in the following ratios.

[0392] Grains (30 parts by weight of brown rice, 15 parts by weight of adlay, and 20 parts by weight of barley),

[0393] Seeds (7 parts by weight of perilla, 8 parts by weight of black beans, and 7 parts by weight of black sesame),

[0394] 0.1 parts by weight of plant extracts,

[0395] 0.5 parts by weight of lingzhi mushroom,

[0396] 0.5 parts by weight of adhesive rehmannia

FORMULATION EXAMPLE 5

Manufacture of Beverages

[0397] 1. Manufacture of health drinks

[0398] 0.1 mg of plant extracts

[0399] 1.000 mg of citric acid

[0400] 100 g of oligosaccharide

[0401] 2 g of plum concentrate

[0402] 1 g of taurine

[0403] Adjusting the total volume to 900 mL with purified water

[0404] After mixing the above ingredients according to a conventional health drink manufacturing method, the mixture was stirred and heated at 85° C. for about 1 hour to obtain a solution. The solution was placed in a filtered and sterilized 2L container, sealed, and sterilized. Thereafter, the filtered solution was refrigerated. Then, the solution was used in preparation of the health drink composition of the present invention.

[0405] As a preferred embodiment, the composition ratio is determined based on ingredients suitable for favorite drinks. However, the composition ratio may be arbitrarily changed according to regional and ethnic preferences such as demand class, demand country, and use purpose.

[0406] 2. Manufacture of vegetable juice

[0407] 1 g of the plant extracts of the present invention was added to 1,000 mL of tomato or carrot juice to prepare vegetable juice for health promotion.

[0408] 3. Manufacture of fruit juice

[0409] 1 g of the plant extracts of the present invention was added to 1,000 mL of apple or grape juice to prepare fruit juice for health promotion.

INDUSTRIAL APPLICABILITY

[0410] A composition comprising plant extracts according to the present invention has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in melanocytes of the skin, promotes skin regeneration and increases skin elasticity or reduces skin wrinkles by promoting collagen synthesis and inhibiting collagenase activity in fibroblasts of the skin, has an anti-inflammatory or a skin soothing effect by suppressing NO generation, increases the amount of moisture in the skin and has a moisturizing effect by promoting generation of hyaluronic acid in fibroblasts, and has an antioxidant effect by scavenging free radicals. In addition, since the composition of the present invention has a broad antibacterial effect against various bacteria, the composition can be used as a cosmetic composition, a pharmaceutical composition, a skin external preparation, or a food composition.