ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION
20230106420 · 2023-04-06
Assignee
- Abivax (Paris, FR)
- Centre National De La Recherche Scientifique (Paris, FR)
- Universite De Montpellier (Montpellier, FR)
- Institut Curie (Paris, FR)
Inventors
- Didier Scherrer (Castelnau le Lez, FR)
- Florence MAHUTEAU (Saint Remy-les-Chevreuse, FR)
- Romain Najman (L'Hay-les-Roses, FR)
- Jamal Tazi (Clapiers, FR)
- Julien SANTO (Grabels, FR)
- Cécile APOLIT (Grabels, FR)
- Frederic LABEGUERE (Toulouse, FR)
- Brice SAUTIER (Toulouse, FR)
- Natacha BIENVENU (Toulouse, FR)
- Elisa AZZALI (Verona, IT)
Cpc classification
C07D409/12
CHEMISTRY; METALLURGY
C07D405/12
CHEMISTRY; METALLURGY
C07F9/6506
CHEMISTRY; METALLURGY
C07D403/12
CHEMISTRY; METALLURGY
C07D401/12
CHEMISTRY; METALLURGY
C07D233/44
CHEMISTRY; METALLURGY
C07D417/12
CHEMISTRY; METALLURGY
C07D413/12
CHEMISTRY; METALLURGY
International classification
C07D233/44
CHEMISTRY; METALLURGY
C07D401/12
CHEMISTRY; METALLURGY
C07D403/12
CHEMISTRY; METALLURGY
C07D405/12
CHEMISTRY; METALLURGY
C07D409/12
CHEMISTRY; METALLURGY
C07D413/12
CHEMISTRY; METALLURGY
C07D417/12
CHEMISTRY; METALLURGY
Abstract
A compound of formula (I) is:
##STR00001##
wherein: X.sup.2 represents a —CO—NR.sub.k— group, a —NR′.sub.k—CO— group, a —O— group, a —CO— group, a —SO.sub.2-group, a —CS—NH— group, a —CH.sub.2—NH—, a
##STR00002##
group, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N; Y.sup.2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, a bridged morpholinyl group, a (C.sub.5-C.sub.11)bicycloalkyl group, an adamantyl group, a piperidinyl group, a (C.sub.1-C.sub.4)alkenyl group, a —PO(OR.sub.a)(OR.sub.b) group, a 5-membered heteroaromatic ring or a —CR.sup.1R.sup.2R.sup.3 group, or any of its pharmaceutically acceptable salt.
Claims
1-13. (canceled)
14. A compound of formula (I): ##STR00241## wherein: ##STR00242## ring and ##STR00243## ring independently mean a phenylene or a pyridylene group, Z″ represents a —CH.sub.2— group or a —CO— group, R.sub.g and R.sub.h independently represent a hydrogen atom, a (C.sub.1-C.sub.4)alkyl group, a (C.sub.3-C.sub.6)cycloalkyl group, a —CH.sub.2CHF.sub.2 group, or a —COCH.sub.3 group, Q is NH or O, X.sup.2 represents a —CO—NR.sub.k— group, wherein R.sub.k represents a hydrogen atom or a methyl group, a —NR′.sub.k—CO— group, wherein R′.sub.k represents a hydrogen atom or a methyl group, a —O— group, a —CO— group, a —SO.sub.2-group, a —CS—NH— group, a —CH.sub.2—NH—, a ##STR00244## group, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N, the ring being optionally substituted by a (C.sub.1-C.sub.4)alkyl group, a halogen atom, a —COOR.sub.p group or ═O, with R.sub.p being a (C.sub.1-C.sub.4)alkyl group, n is 0, 1, 2 or 3, m and m′ are independently 0, 1 or 2, Y.sup.2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, a bridged morpholinyl group, optionally substituted by a halogen atom, a (C.sub.5-C.sub.11)bicycloalkyl group, an adamantyl group, a piperidinyl group, optionally interrupted by a SO.sub.2 group, a (C.sub.1-C.sub.4)alkenyl group, a —PO(OR.sub.a)(OR.sub.b) group, a 5-membered heteroaromatic ring comprising one or two heteroatom(s) selected from an oxygen and a nitrogen atom, or a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, the (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, itself optionally substituted by a hydroxy group, halogen atom, trifluoromethyl group, cyano group, phosphonate group, oxo group or (C.sub.1-C.sub.4)alkoxy group and the (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on the R.sup.1 and/or R.sup.2 by one or two oxygen atom(s), by a sulfur atom, by a nitrogen atom or by a —SO.sub.2— group, R and R′ independently represent a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and optionally interrupted by a —SO.sub.2— group or a —SO— group, a (C.sub.1-C.sub.4)alkenyl group, a (C.sub.3-C.sub.6)cycloalkyl group, a tetrahydrofuranyl group, a tetrahydropyranyl group, a trifluoromethyl group, a furanyl group, a halogen atom, a cyano group, or a (C.sub.1-C.sub.5)alkoxy group, R.sub.a and R.sub.b independently represent a hydrogen atom or a (C.sub.1-C.sub.4)alkyl group, or any of its pharmaceutically acceptable salt.
15. The compound of formula (I) according to claim 14, wherein ##STR00245## ring and ##STR00246## ring and ring both represent a phenylene group or ##STR00247## ring represents a pyridylene group and ##STR00248## ring represents a phenylene group, or any of its pharmaceutically acceptable salt.
16. The compound of formula (I) according to claim 14, wherein Q is a NH group or any of its pharmaceutically acceptable salt.
17. The compound of formula (I) according to claim 14, wherein R.sub.g and R.sub.h represent a hydrogen atom or any of its pharmaceutically acceptable salt.
18. The compound of formula (I) according to claim 14, wherein X.sup.2 represents a —CO—NH— group, a —NH—CO— group, a —O— group, a —CO— group, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N, the ring being optionally substituted by a (C.sub.1-C.sub.4)alkyl group, a halogen atom, a —COOR.sub.p group or ═O, with R.sub.p being a (C.sub.1-C.sub.4)alkyl group, or any of its pharmaceutically acceptable salt.
19. The compound of formula (I) according to claim 14, wherein Y.sup.2 represents a hydrogen atom, a halogen atom, a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, a bridged morpholinyl group, optionally substituted by a halogen atom, a (C.sub.5-C.sub.11)bicycloalkyl group, an adamantyl group, a (C.sub.1-C.sub.4)alkenyl group, a —PO(OR.sub.a)(OR.sub.b) group, an oxazolyl, an isoxazolyl, a pyrazolyl or an imidazolyl, or a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, the (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, itself optionally substituted by a hydroxy group, halogen atom, trifluoromethyl group or cyano group, phosphonate group oxo group and the (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on the R.sup.1 and/or R.sup.2 by one or two oxygen atom(s), by a sulfur atom, by a nitrogen atom or by a —SO.sub.2— group, with R.sub.a and R.sub.b being as defined in claim 14, or any of its pharmaceutically acceptable salt.
20. The compound of formula (I) according to claim 14, wherein R and R′ independently represent a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and optionally interrupted by a —SO.sub.2— group or a —SO— group, a (C.sub.3-C.sub.6)cycloalkyl group, a tetrahydrofuranyl group, a tetrahydropyranyl group, a trifluoromethyl group, a furanyl group, a chlorine or fluorine atom, a cyano group, or a (C.sub.1-C.sub.5)alkoxy group, or any of its pharmaceutically acceptable salt.
21. The compound of formula (I) according to claim 14 selected from TABLE-US-00004 N.sup.o Structure 1
22. A therapeutic method for treating and/or preventing a subject from a RNA virus infection comprising the administration of a therapeutically effective quantity of a compound of formula (I) as defined in claim 14 or any of its pharmaceutically acceptable salts, or of any of compounds (1) to (181) TABLE-US-00005 No Structure 1
23. A therapeutic method for treating and/or preventing a subject from a RSV viral infection or a virus-related condition comprising the administration of a therapeutically effective quantity of a compound of formula (I) as defined in claim 14 or any of its pharmaceutically acceptable salts, or of any of compounds (1) to (181) TABLE-US-00006 No Structure 1
24. A pharmaceutical composition comprising at least one of formula (I) as defined in claim 14 or any of its pharmaceutically acceptable salts, and any of compounds (1) to (181) TABLE-US-00007 N.sup.o Structure 1
25. A synthesis process for manufacturing new compounds of formula (I) as defined in claim 14, wherein Q is NH, comprising at least a step of coupling a compound of formula (II) (i) a step of coupling a compound of formula (II) ##STR00973## with a compound of formula (III) ##STR00974## wherein R, R′, m, m′, n, ##STR00975## ring, ##STR00976## ring, X.sup.2, Y.sup.2 are as defined in claim 14, R.sub.c is an alkyl group in presence of an inorganic base and a diphosphine and in the presence of an organometallic catalyst, to obtain a compound of formula (IV) ##STR00977## wherein R.sub.c means an alkyl group and R, R′, m, m′, n, ##STR00978## ring, ##STR00979## ring, X.sup.2, Y.sup.2 are as defined in claim 14, followed by a hydrolysis leading to a compound of formula ##STR00980## wherein R.sub.c is a hydrogen atom and R, R′, m, m′, n, ##STR00981## ring, ##STR00982## ring, X.sup.2, Y.sup.2 are as defined in claim 14, and (ii) a step of reacting a compound of formula (V) with a compound or formula ##STR00983## wherein R.sub.g and R.sub.h are as defined in claim 14, in presence of an organic base and in presence of a coupling agent to obtain a compound for formula (I) wherein Q is NH, as defined in claim 14.
26. The synthesis process for manufacturing new compounds of formula (I) as defined in claim 14, wherein Q is O, comprising at least a step of coupling a compound of formula (II′) ##STR00984## with a compound of formula (III) ##STR00985## wherein R, R′, R.sub.c, R.sub.h, R.sub.g, m, m′, n, ##STR00986## ring, ##STR00987## ring, X.sup.2, Y.sup.2 are as defined in claim 14 and X is a fluorine atom, in presence of an inorganic base, to obtain a compound of formula (I), wherein Q is O, as defined in claim 14.
Description
DETAILED DESCRIPTION OF THE INVENTION
[0039] The inventors have surprisingly found that aryl-N-aryl compounds are endowed with a broad-spectrum activity against RNA viruses, and more particularly single-stranded RNA viruses belonging to Group V of the Baltimore classification. Groups IV and V include respectively (+)ssRNA viruses and (−)ssRNA viruses; which also refer to positive-sense single-stranded RNA viruses and negative-sense single-stranded RNA viruses. For reference, the content of the «Baltimore classification» is considered in light of the Classification and Nomenclature of viruses as set forth in the 10th report on Virus Taxonomy dated 2017.
[0040] According to one aspect, the present invention relates to a compound of formula (I)
##STR00003##
[0041] wherein:
##STR00004##
ring and
##STR00005##
ring independently mean a phenylene or a pyridylene group, [0042] Z″ represents a —CH.sub.2— group or a —CO— group, [0043] R.sub.g and R.sub.h independently represent a hydrogen atom, a (C.sub.1-C.sub.4)alkyl group, a (C.sub.3-C.sub.6)cycloalkyl group, a —CH.sub.2CHF.sub.2 group, or a —COCH.sub.3 group, [0044] Q is NH or O, [0045] X.sup.2 represents [0046] a —CO—NR.sub.k— group, wherein Rk represents a hydrogen atom or a methyl group, [0047] a —NR'k-CO— group, wherein R′k represents a hydrogen atom or a methyl group, [0048] a —O— group, [0049] a —CO— group, [0050] a —SO.sub.2-group, [0051] a —CS—NH— group, [0052] a —CH.sub.2—NH— group, a
##STR00006##
group, [0053] or [0054] a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N, such as a triazole, a pyrazoline, an oxazole, an oxazoline, an oxazolidine, an imidazole, a pyrazole, an imidazoline, a tetrazole or an oxadiazole, said ring being optionally substituted by a (C.sub.1-C.sub.4)alkyl group, a halogen atom, or ═O, [0055] n is 0, 1, 2 or 3, [0056] m and m′ are independently 0, 1 or 2, [0057] Y.sup.2 represents [0058] a hydrogen atom, [0059] a halogen atom, [0060] a hydroxyl group, [0061] a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, [0062] a bridged morpholinyl group, optionally substituted by a halogen atom, [0063] a (C.sub.5-C.sub.11)bicycloalkyl group, [0064] a piperidinyl group, optionally interrupted by a SO.sub.2 group, [0065] a (C.sub.1-C.sub.4)alkenyl group, [0066] a —PO(OR.sub.a)(OR.sub.b) group, [0067] or [0068] a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, said (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, itself optionally substituted by a hydroxy group, halogen atom, trifluoromethyl group, cyano group, phosphonate group or (C.sub.1-C.sub.4)alkoxy group and said (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on said R.sup.1 and/or R.sup.2 by one or two oxygen atom(s) or by a —SO.sub.2— group, [0069] R and R′ independently represent [0070] a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and optionally interrupted by a —SO.sub.2— group or a —SO— group, [0071] a (C.sub.1-C.sub.4)alkenyl group, [0072] a (C.sub.3-C.sub.6)cycloalkyl group, [0073] a tetrahydrofuranyl group, [0074] a tetrahydropyranyl group, [0075] a trifluoromethyl group, [0076] a furanyl group, [0077] a halogen atom, [0078] a cyano group, [0079] or [0080] a (C.sub.1-C.sub.5)alkoxy group, [0081] R.sub.a and R.sub.b independently represent a hydrogen atom or a (C.sub.1-C.sub.4)alkyl group, [0082] or any of its pharmaceutically acceptable salt.
[0083] According to one aspect, the present invention relates to a compound of formula (I)
##STR00007##
[0084] wherein:
##STR00008##
ring and
##STR00009##
ring independently mean a phenylene or a pyridylene group, [0085] Z″ represents a —CH.sub.2— group or a —CO— group, [0086] R.sub.g and R.sub.h independently represent a hydrogen atom, a (C.sub.1-C.sub.4)alkyl group, a (C.sub.3-C.sub.6)cycloalkyl group or a —COCH.sub.3 group, [0087] Q is NH or O, [0088] X.sup.2 represents [0089] a —CO—NR.sub.k— group, wherein R.sub.k represents a hydrogen atom or a methyl group, [0090] a —NR′.sub.k—CO— group, wherein R′.sub.k represents a hydrogen atom or a methyl group, [0091] a —O— group, [0092] a —CO— group, [0093] a —SO.sub.2-group, [0094] a —CS—NH— group, [0095] a —CH.sub.2—NH— group, [0096] a
##STR00010##
group, [0097] or [0098] a divalent 5-membered heteroaromatic ring comprising 1, 2, 3 or 4 heteroatoms, such as a triazole, an imidazole, a tetrazole or an oxadiazole, [0099] n is 0, 1, 2 or 3, [0100] m and m′ are independently 0, 1 or 2, [0101] Y.sup.2 represents [0102] a hydrogen atom, [0103] a halogen atom, [0104] a hydroxyl group, [0105] a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group, [0106] a piperidinyl group, optionally interrupted by a SO.sub.2 group, [0107] a (C.sub.1-C.sub.4)alkenyl group, [0108] a —PO(OR.sub.a)(OR.sub.b) group, [0109] or [0110] a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, said (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, halogen atom, trifluoromethyl group, cyano group or (C.sub.1-C.sub.4)alkoxy group and said (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on said R.sup.1 and/or R.sup.2 by one or two oxygen atom(s) or by a —SO.sub.2— group, [0111] R and R′ independently represent [0112] a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and optionally interrupted by a —SO.sub.2— group or a —SO— group, [0113] a (C.sub.1-C.sub.4)alkenyl group, [0114] a (C.sub.3-C.sub.6)cycloalkyl group, [0115] a tetrahydrofuranyl group, [0116] a tetrahydropyranyl group, [0117] a trifluoromethyl group, [0118] a furanyl group, [0119] a halogen atom, [0120] or [0121] a (C.sub.1-C.sub.5)alkoxy group, [0122] R.sub.a and R.sub.b independently represent a hydrogen atom or a (C.sub.1-C.sub.4)alkyl group, or any of its pharmaceutically acceptable salt.
[0123] In other words,
##STR00011##
represents a group A
##STR00012##
or a group (B)
##STR00013##
[0124] According to a first aspect, the present invention relates to a compound of formula (I):
##STR00014##
wherein:
##STR00015##
ring and
##STR00016##
ring independently mean a phenylene or a pyridylene group, [0125] Z″ represents a —CH.sub.2— group or a —CO— group, [0126] R.sub.g and R.sub.h independently represent a hydrogen atom, a (C.sub.1-C.sub.4)alkyl group, a (C.sub.3-C.sub.6)cycloalkyl group, a —CH.sub.2CHF.sub.2 group, or a —COCH.sub.3 group, [0127] Q is NH or O, [0128] X.sup.2 represents [0129] a —CO—NR.sub.k— group, wherein Rk represents a hydrogen atom or a methyl group, [0130] a —NR′.sub.k—CO— group, wherein R′.sub.k represents a hydrogen atom or a methyl group, [0131] a —O— group, [0132] a —CO— group, [0133] a —SO.sub.2-group, [0134] a —CS—NH— group, [0135] a —CH.sub.2—NH—, [0136] a
##STR00017##
group, [0137] or [0138] a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N, such as a triazolyl, a pyrazolinyl, an oxazolyl, an oxazolinyl, an oxazolidinyl, an imidazolyl, a dihydroimidazolyl, a pyrazolyl, an imidazolinyl, a tetrazolyl or an oxadiazolyl, said ring being optionally substituted by a (C.sub.1-C.sub.4)alkyl group, a halogen atom, a —COOR.sub.p group or ═O, with R.sub.p being a (C.sub.1-C.sub.4)alkyl group, [0139] n is 0, 1, 2 or 3, [0140] m and m′ are independently 0, 1 or 2, [0141] Y.sup.2 represents [0142] a hydrogen atom, [0143] a halogen atom, [0144] a hydroxyl group, [0145] a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, [0146] a bridged morpholinyl group, optionally substituted by a halogen atom, [0147] a (C.sub.5-C.sub.11)bicycloalkyl group, [0148] an adamantyl group, a piperidinyl group, optionally interrupted by a SO.sub.2 group, [0149] a (C.sub.1-C.sub.4)alkenyl group, [0150] a —PO(OR.sub.a)(OR.sub.b) group, [0151] a 5-membered heteroaromatic ring comprising one or two heteroatom(s) selected from an oxygen and a nitrogen atom, such as an oxazolyl, isoxazolyl, a pyrazolyl and an imidazolyl, in particular an oxazolyl, or [0152] a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, said (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, itself optionally substituted by a hydroxy group, halogen atom, trifluoromethyl group, cyano group, phosphonate group, oxo group or (C.sub.1-C.sub.4)alkoxy group and said (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on said R.sup.1 and/or R.sup.2 by one or two oxygen atom(s), by a sulfur atom, by a nitrogen atom or by a —SO.sub.2— group, [0153] R and R′ independently represent [0154] a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and optionally interrupted by a —SO.sub.2— group or a —SO— group, [0155] a (C.sub.1-C.sub.4)alkenyl group, [0156] a (C.sub.3-C.sub.6)cycloalkyl group, [0157] a tetrahydrofuranyl group, [0158] a tetrahydropyranyl group, [0159] a trifluoromethyl group, [0160] a furanyl group, [0161] a halogen atom, [0162] a cyano group, [0163] or [0164] a (C.sub.1-C.sub.5)alkoxy group, [0165] R.sub.a and R.sub.b independently represent a hydrogen atom or a (C.sub.1-C.sub.4)alkyl group, [0166] or any of its pharmaceutically acceptable salt.
[0167] According to a second aspect, the present invention relates to a compound of foimula (I) as defined above or any of its pharmaceutically acceptable salts, and any of compounds (1) to (181) as defined herein after or any of its phaiiiiaceutically acceptable salts, for use as a medicament.
[0168] According to a third aspect, the present invention relates to compounds of formula (I) as defined above or any of its pharmaceutically acceptable salts, and any of compounds (1) to (181) as defined herein after or any of its pharmaceutically acceptable salts for use in the treatment and/or prevention of a RNA virus infection caused by a RNA virus belonging to group V of the Baltimore classification, and in particular a RSV viral infection or a virus-related condition.
[0169] The above-mentioned compounds (I) are particularly suitable for treating or preventing a virus infection or related condition, in particular a RNA virus infection caused by a RNA virus belonging to group V of the Baltimore classification or related condition, and most preferably a RSV viral infection or a virus-related condition.
[0170] According to a particular embodiment, the present invention relates to a compound of formula (I) as defined above, wherein
##STR00018##
ring and
##STR00019##
ring both represent a phenylene group or
##STR00020##
ring represents a pyridylene group and
##STR00021##
ring represents a phenylene group, or any of its pharmaceutically acceptable salt.
[0171] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein Q is a NH group or any of its pharmaceutically acceptable salt.
[0172] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein R.sub.g and R.sub.h represent a hydrogen atom or any of its pharmaceutically acceptable salt.
[0173] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein X.sup.2 represents [0174] a —CO—NH— group, [0175] a —NH—CO— group, [0176] a —O— group, [0177] a —CO— group, [0178] or [0179] a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N, such as a triazole, an imidazole, an imidazoline, an oxazoline, an oxazolidine, or a tetrazole, said ring being optionally substituted by a (C.sub.1-C.sub.4)alkyl group, a halogen atom or ═O, [0180] or any of its pharmaceutically acceptable salt.
[0181] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein X.sup.2 [0182] a —CO—NH— group, [0183] a —NH—CO— group, [0184] a —O— group, [0185] a —CO— group, [0186] or [0187] a divalent 5-membered heteroaromatic ring comprising at least 2 nitrogen [0188] atoms, such as a triazole, an imidazole or a tetrazole, or any of its pharmaceutically acceptable salt.
[0189] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein X.sup.2 represents [0190] a —CO—NH— group, [0191] a —NH—CO— group, [0192] a —O— group, [0193] a —CO— group, [0194] or [0195] a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N, such as a triazolyl, an imidazolyl, an imidazolinyl, an oxazolyl, an oxazolinyl, an oxazolidinyl, a dihydroimidazolyl, or a tetrazolyl, said ring being optionally substituted by a (C.sub.1-C.sub.4)alkyl group, a halogen atom, a —COOR.sub.p group or ═O, with R.sub.p being a (C.sub.1-C.sub.4)alkyl group, or any of its pharmaceutically acceptable salt.
[0196] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein Y.sup.2 represents [0197] a hydrogen atom, [0198] a halogen atom, [0199] a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, [0200] a bridged morpholinyl group, optionally substituted by a halogen atom, [0201] a (C.sub.5-C.sub.11)bicycloalkyl group, [0202] a (C.sub.1-C.sub.4)alkenyl group, [0203] a —PO(OR.sub.a)(OR.sub.b) group, [0204] or [0205] a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, said (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, itself optionally substituted by a hydroxy group, halogen atom, trifluoromethyl group or cyano group, phosphonate group and said (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on said R.sup.1 and/or R.sup.2 by one or two oxygen atom(s) or by a —SO.sub.2— group, with R.sub.a and R.sub.b being as defined above, [0206] or any of its pharmaceutically acceptable salt.
[0207] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein Y.sup.2 represents [0208] a hydrogen atom, [0209] a halogen atom, [0210] a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group, p1 a (C.sub.1-C.sub.4)alkenyl group, [0211] a —PO(OR.sub.a)(OR.sub.b) group, or [0212] a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R′, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, said (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, halogen atom, trifluoromethyl group or cyano group and said (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on said R.sup.1 and/or R.sup.2 by one or two oxygen atom(s) or by a —SO.sub.2— group, with R.sub.a and R.sub.b being as defined in claim 1, [0213] or any of its pharmaceutically acceptable salt.
[0214] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein Y.sup.2 represents [0215] a hydrogen atom, [0216] a halogen atom, [0217] a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, [0218] a bridged morpholinyl group, optionally substituted by a halogen atom, a (C5-C.sub.11)bicycloalkyl group, [0219] an adamantyl group, [0220] a (C.sub.1-C.sub.4)alkenyl group, [0221] a —PO(OR.sub.a)(OR.sub.b) group, [0222] an oxazolyl, an isoxazolyl, a pyrazolyl or an imidazolyl, in particular an oxazolyl, [0223] or [0224] a —CR.sup.1R.sup.2R.sup.3 group, wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom, a fluorine atom or a (C.sub.1-C.sub.4)alkyl group, being understood that no more than one of R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom, or R.sup.1 and R.sup.2 form together with the carbon atom bearing them a (C.sub.3-C.sub.8)cycloalkyl group, said (C.sub.3-C.sub.8)cycloalkyl group being optionally substituted by one or two (C.sub.1-C.sub.4)alkyl group, itself optionally substituted by a hydroxy group, halogen atom, trifluoromethyl group or cyano group, phosphonate group oxo group and said (C.sub.3-C.sub.8)cycloalkyl group being optionally interrupted on said R.sup.1 and/or R.sup.2 by one or two oxygen atom(s), by a sulfur atom, by a nitrogen atom or by a —SO.sub.2— group, [0225] with R.sub.a and R.sub.b being as defined in claim 1,
or any of its pharmaceutically acceptable salt.
[0226] In a more particular embodiment, the polycyclic (bicyclic) alkyl group may be chosen in the group consisting in spiro[2.2]pentyl, spiro[5.5]undecanyl, spiro[3.4]octanyl, spiro[4.5]decanyl, bicyclo[1.1.0]butyl, bicyclo[2.1.1]hexyl, bicyclo[3.2.0]heptyl, bicyclo[3.3.0]octyl, bicyclo[4.3.0]nonyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl, bicyclo[3.2.1]octyl, bicyclo[1.1.1]pentyl, oxabicyclo[1.1.1]pentyl, oxabicyclo[2.1.1]hexyl, oxabicyclo[2.2.1]heptyl, oxabicyclo[4.1.0]heptyl, oxabicyclo[3.2.1]octyl and cubyl, and more particularly consisting in bicyclo[1.1.1]pentyl, oxabicyclo[1.1.1]pentyl, bicyclo[2.1.1]hexyl, oxabicyclo[2.1.1]hexyl, and even more particularly is bicyclo[1.1.1]pentyl.
[0227] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein R and R′ independently represent [0228] a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and [0229] optionally interrupted by a —SO.sub.2— group or a —SO— group, [0230] a (C.sub.3-C.sub.6)cycloalkyl group, [0231] a tetrahydrofuranyl group, [0232] a tetrahydropyranyl group, [0233] a trifluoromethyl group, [0234] a furanyl group, [0235] a chlorine or fluorine atom, [0236] a cyano group, [0237] or [0238] a (C.sub.1-C.sub.5)alkoxy group,
or any of its pharmaceutically acceptable salt.
[0239] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein R and R′ independently represent [0240] a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and optionally interrupted by a —SO.sub.2— group or a —SO— group, [0241] a (C.sub.3-C.sub.6)cycloalkyl group, [0242] a tetrahydrofuranyl group, [0243] a tetrahydropyranyl group, [0244] a trifluoromethyl group, [0245] a furanyl group, [0246] a chlorine or fluorine atom, [0247] or [0248] a (C.sub.1-C.sub.5)alkoxy group, [0249] or any of its pharmaceutically acceptable salt.
[0250] In another embodiment, the present invention relates to a compound of formula (I) as defined above, wherein R and R′ independently represent [0251] a (C.sub.1-C.sub.4)alkyl group, optionally substituted by a hydroxyl group, and optionally interrupted by a —SO.sub.2— group or a —SO— group, [0252] a (C.sub.3-C.sub.6)cycloalkyl group, [0253] a tetrahydrofuranyl group, [0254] a tetrahydropyranyl group, [0255] a trifluoromethyl group, [0256] a furanyl group, [0257] a chlorine or fluorine atom, [0258] a cyano group, [0259] or [0260] a (C.sub.1-C.sub.5)alkoxy group,
[0261] or any of its pharmaceutically acceptable salt.
[0262] Any combination of the above-defined embodiments for R, R′, Z″, R.sub.g, R.sub.h, Q, m, m′,
##STR00022##
ring,
##STR00023##
ring, X.sup.2, n and Y.sup.2 with each other does form part of the instant invention.
[0263] According to a preferred embodiment of the present invention, the compound of formula (I) is chosen from: [0264] (1) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-[(3-{[1-(propan-2-yl)cyclopropyl]carbamoyl}phenyl)amino]benzamide [0265] (2) 3-cyclopentyl-N-[(2E)-imidazolidin-2-ylidene]-4-{[3-(2-methylpropanamido)phenyl]amino}benzamide [0266] (3) 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-cyclopentyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0267] (4) 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide
[0268] (5) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-{[3-(4-methylpentanamido)phenyl]amino}benzamide [0269] (6) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[(4-methylpentan-2-yl)carbamoyl]phenyl}amino)benzamide [0270] (7) 2-cyclopropyl-3-[(2-cyclopropyl-4-{[(2E)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-(3-methylbutyl)benzamide [0271] (8) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[(3-methylbutyl)carbamoyl]phenyl}amino)benzamide [0272] (9) 3-tert-butyl-4-{[2-cyclopropyl-3-(morpholine-4-carbonyl)phenyl]amino}- N-[(2E)-imidazolidin-2-ylidene]benzamide [0273] (10) 4-({2-chloro-3-[(3-methylbutyl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0274] (11) 4-({2-chloro-3-[(propan-2-yl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0275] (12) 4-({2-chloro-3-[2-(1,4-dioxan-2-yl)ethoxy]pheny}amino)-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0276] (13) 4-[(3-cyclopropaneamidophenyl)amino]-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0277] (14) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(1-methylcyclopropyl)carbarnoyl]phenyl}amino)benzamide [0278] (15) 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-N-[(2E)-imidazolidin-2-ylidene]-3-(oxolan-3-yl)benzamide [0279] (16) 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-N-[(2E)-imidazolidin-2-ylidene]-3-(trifluoromethyl)benzamide [0280] (17) 3-tert-butyl-N-[(2E)-1-methylimidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}lamino)benzamide [0281] (18) 3-cyclobutyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)benzamide [0282] (19) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0283] (20) 3-tert-butyl-4-{[3-(2,2-dimethylpropanamido)phenyl]amino}-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0284] (21) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-{[3-(1-methylcyclopropaneamido)phenyl]amino}benzamide [0285] (22) 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0286] (23) 4-({2-chloro-3-[(1,4-dioxan-2-yl)methoxy]phenyl}amino)-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0287] (24) 3-tert-butyl-4-({3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-N-[(2E)-1-methylimidazolidin-2-ylidene]benzamide [0288] (25) 4-{[2-chloro-3-(cyclopropylcarbamoyl)phenyl]amino}-3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0289] (26) 3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]-4-{[3-(2-methylpropanamido)phenyl]amino}benzamide [0290] (27) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({2-methoxy-3-[(3-methylbutyl)carbamoyl]phenyl}amino)benzamide [0291] (28) 4-({2-chloro-3-[(oxolan-3-yl)carbarnoyl]phenyl}amino)-3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0292] (29) N-[(2E)-imidazolidin-2-ylidene]-4-({3-[(3-methylbutyl)carbarnoyl]phenyl}amino)-3-(prop-1-en-2-yl)benzamide [0293] (30) 3-(2-hydroxypropan-2-yl)-N-[(2E)-imidazolidin-2-ylidene]-4-{[3-(morpholine-4-carbonyl)-2-(trifluoromethyl)phenyl]amino}benzamide [0294] (31) 3-cyclopropyl-4-({3-[(1-ethylcyclopropyl)carbamoyl]phenyl}amino)-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0295] (32) 3-cyclopropyl-4-({3-fluoro-5-[(propan-2-yl)carbamoyl]phenyl}amino)-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0296] (33) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-[(3-{[2-(oxan-3-yl)ethyl]carbamoyl}phenyl)amino]benzamide [0297] (34) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamothioyl]phenyl}amino)benzamide [0298] (35) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-[(3-{[2-(oxan-2-yl)ethyl]carbamoyl}phenyl)amino]benzamide [0299] (36) 3-cyclopropyl-N-[(2E)-1-methylimidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0300] (37) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-{[3-(2-methylpropanamido)phenyl]amino}benzamide [0301] (38) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[methyl(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0302] (39) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-[(3-{[2-(oxan-4-yl)ethyl]carbamoyl}phenyl)amino]benzamide [0303] (40) 2-[(2-cyclopropyl-4-{[(2E)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-3-methyl-N-(3-methylbutyl)pyridine-4-carboxamide [0304] (41) 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropyl-N-[(2E)-4-oxoimidazolidin-2-ylidene]benzamide [0305] (42) 4-{[2-cyclopropyl-3-(morpholine-4-carbonyl)phenyl]amino}-N-[(2Z)-imidazolidin-2-ylidene]-3-(trifluoromethyl)benzamide [0306] (43) 3-cyclopropyl-N-[(2E)-1-cyclopropylimidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0307] (44) 3-(2-hydroxypropan-2-yl)-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[(3-methylbutyl)carbamoyl]phenyl}amino)benzamide [0308] (45) 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-(2-hydroxypropan-2-yl)-N-[(2E)-imidazolidin-2-ylidene]benzamide [0309] (46) N-[(2E)-1-acetylimidazolidin-2-ylidene]-4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropylbenzamide [0310] (47) 3-cyclopropyl-4-({3-fluoro-5-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0311] (48) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-[(3-{[2-(oxolan-3-yl)ethyl]carbamoyl}phenyl)amino]benzamide [0312] (49) 3-tert-butyl-N-[(2E)-4-oxoimidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0313] (50) 4-({2-chloro-3-[(oxan-4-yl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0314] (51) 3-cyclopentyl-4-({3-[(1,4-dioxan-2-yl)methoxy]phenyl}amino)-N-[(2E)-imidazolidin-2-ylidene]benzamide [0315] (52) 3-tert-butyl-4-({3-[(1,4-dioxan-2-yl)methoxy]phenyl}amino)-N-[(2E)-imidazolidin-2-ylidene]benzamide [0316] (53) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-[(3-{[1-(trifluoromethyl)cyclopropyl]carbamoyl}phenyl)amino]benzamide [0317] (54) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-({2-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0318] (55) 2-[(2-tert-butyl-4-{[(2E)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-(3-methylbutyl)pyridine-4-carboxamide [0319] (56) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-({2-[(2-methylpropyl)carbamoyl]phenyl}amino)benzamide [0320] (57) 4-{[3-(5-chloro-1H-imidazol-2-yl)-2-methylphenyl]amino}-3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0321] (58) 3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]-4-[(3-{[2-(oxan-4-yl)ethyl]carbamoyl}phenyl)amino]benzamide [0322] (59) N-[(2E)-imidazolidin-2-ylidene]-3-(oxolan-3-yl)-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0323] (60) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[1-(3-methylbut-2-en-1-yl)-1H-1,2,3,4-tetrazol-5-yl]phenyl}amino)benzamide [0324] (61) 3-cyclopropyl-N-[(2E)-1-methyl-5-oxoimidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0325] (62) 3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]-4-({2-[(3-methylbutyl)carbamoyl]phenyl}amino)benzamide [0326] (63) N-[(2E)-imidazolidin-2-ylidene]-4-{[3-(2-methylpropanamido)phenyl]amino}-3-(oxolan-3-yl)benzamide [0327] (64) 4-({3-[(1-cyanocyclopropyl)carbamoyl]-2-methylphenyl}amino)-3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0328] (65) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]-5-(trifluoromethyl)phenyl}amino)benzamide [0329] (66) 3-cyclopropyl-4-({4-fluoro-3-[(propan-2-yl)carbamoyl]phenyl}amino)-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0330] (67) 3-(2-hydroxypropan-2-yl)-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[3-(oxan-4-yl)propoxy]phenyl}amino)benzamide [0331] (68) N-{3-[(2-cyclopropyl-4-{[(2E)-imidazolidin-2-ylidene]carbamoyl}phenypamino]-2-methylphenyl}-3-methyloxetane-3-carboxamide [0332] (69) N-[(2Z)-imidazolidin-2-ylidene]-3-(oxan-4-yl)-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0333] (70) 3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]-4-({2-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0334] (71) 3-tert-butyl-N-[(2Z)-1,3-dimethylimidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0335] (72) 3-chloro-N-[(2E)-imidazolidin-2-ylidene]-4-{[3-(2-methylpropanamido)phenyl]amino}benzamide [0336] (73) 3-cyclopropyl-4-{[3-fluoro-5-(morpholine-4-carbonyl)phenyl]amino}-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0337] (74) 2-[(2-tert-butyl-4-{[(2E)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-[2-(oxan-4-yl)ethyl]pyridine-4-carboxamide [0338] (75) 3-cyclopropyl-4-{[3-(N,2-dimethylpropanamido)phenyl]amino}-N-[(2E)-imidazolidin-2-ylidene]benzamide [0339] (76) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-[(3-{[(propan-2-yl)carbamoyl]methyl}phenyl)amino]benzamide [0340] (77) 3-cyclopropyl-4-({2-fluoro-5-[(propan-2-yl)carbamoyl]phenyl}amino)-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0341] (78) 4-{[2-cyclopropyl-3-(morpholine-4-carbonyl)phenyl]amino}-3-(2-hydroxypropan-2-yl)-N-[(2E)-imidazolidin-2-ylidene]benzamide [0342] (79) 3-(furan-3-yl)-N-[(2E)-imidazolidin-2-ylidene]-4-[(3-{[2-(oxan-4-yl)ethyl]carbamoyl}phenyl)amino]benzamide [0343] (80) 3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]-4-({2-[(2-methylpropyl)carbamoyl]phenyl}amino)benzamide [0344] (81) 3-cyclopropyl-N-[(2E)-1-methyl-4-oxoimidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0345] (82) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-[(3-{3-[(propan-2-yl)amino]oxetan-3-yl}phenyl)amino]benzamide [0346] (83) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(2-methylpropanamido)methyl]phenyl}amino)benzamide [0347] (84) 3-(2-hydroxypropan-2-yl)-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[3-(oxan-4-yl)propanesulfonyl]phenyl}amino)benzamide [0348] (85) 3-(2-hydroxypropan-2-yl)-N-[(2E)-imidazolidin-2-ylidene]-4-({3-[2-(oxan-4-yl)ethoxy]phenyl}amino)benzamide [0349] (86) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(1-methylcyclopropyl)carbamoyl]-5-(trifluoromethyl)phenyl}amino)benzamide [0350] (87) 3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]-4-{2-[(3-methylbutyl)carbamoyl]phenoxy}benzamide [0351] (88) 4-({3-[2-(1,4-dioxan-2-yl)ethoxy]phenyl}amino)-3-(2-hydroxypropan-2-yl)-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0352] (89) 3-[(2-cyclopropyl-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-2-methylphenyl diethyl phosphate [0353] (90) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[2-(3-methylbut-2-en-1-yl)-2H-1,2,3,4-tetrazol-5-yl]phenyl}amino)benzamide [0354] (91) 3-cyclopropyl-5-fluoro-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0355] (92) 3-[(2-cyclopropyl-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenypamino]-2-(furan-3-yl)-N-(propan-2-yl)benzamide [0356] (93) 3-tert-butyl-N-[(2E)-imidazolidin-2-ylidene]-4-[2-(4-methylpentanamido)phenoxy]benzamide [0357] (94) 4-({2-chloro-3-[(1,1-dioxo-1λ.sup.6-thian-4-yl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0358] (95) 3-cyclopentyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(oxolan-3-yl)carbamoyl]phenyl}amino)benzamide [0359] (96) 3-cyclopentyl-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(oxan-4-yl)carbamoyl]phenyl}amino)benzamide [0360] (97) 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-N-[(2E)-imidazolidin-2-ylidene]-3-(oxolan-2-yl)benzamide [0361] (98) 3-cyclopropyl-4-({2-fluoro-3-[(propan-2-yl)carbamoyl]phenyl}amino)-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0362] (99) 4-[(2-cyclopropyl-6-fluoro-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-3-fluoro-N-(1-methylcyclopropyl)pyridine-2-carboxamide [0363] (100) 3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]-4-[2-(4-methylpentanamido)phenoxy]benzamide [0364] (101) 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-N-[(2E)-imidazolidin-2-ylidene]-3-methanesulfinylbenzamide [0365] (102) 2-chloro-3-[(4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}-2-methanesulfonylphenyl)amino]-N-(1-methylcyclopropyl)benzamide [0366] (103) 4-{[2-chloro-3-(1,1-dioxo-1λ.sup.6-thiomorpholine-4-carbonyl)phenyl]amino}-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0367] (104) 4-({2-chloro-3-[3-(propan-2-yl)morpholine-4-carbonyl]phenyl}amino)-3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0368] (105) 4-({2-chloro-3-[2-(propan-2-yl)morpholine-4-carbonyl]phenyl}amino)-3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0369] (106) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-5-methyl-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide [0370] (107) 3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]-4-[(3-{[1-(2-methylpropyl)cyclopropyl]carbamoyl}phenyl)amino]benzamide [0371] (108) N-{3-[(2-cyclopropyl-4-{[(2E)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]phenyl}oxolane-2-carboxamide [0372] (109) 4-[(2-chloro-3-{[(oxolan-2-yl)methyl]carbamoyl}phenyl)amino]-3-cyclopropyl-N-[(2E)-imidazolidin-2-ylidene]benzamide [0373] (110) N-[(2E)-1-acetylimidazolidin-2-ylidene]-3-cyclopropyl-4-{[3-(2-methylpropanamido)phenyl]amino}benzamide [0374] (111) 4-({3-[(1-tert-butylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[(2Z)-imidazolidin-2-ylidene]benzamide [0375] (112) 4-({3-cyano-5-[(propan-2-yl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0376] (113) 3-cyclopropyl-N-[1-(2,2-difluoroethyl)imidazolidin-2-ylidene]-4-{[3-(2-methylpropanamido)phenyl]amino}benzamide, [0377] (114) 4-[(2-chloro-3-{[1-(trifluoromethyl)cyclopropyl]carbamoyl}phenyl)amino]-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0378] (115) 3-cyclopropyl-N-[imidazolidin-2-ylidene]-4-{[3-(morpholine-4-carbonyl)-2-(trifluoromethyl)phenyl]amino}benzamide, [0379] (116) 3-cyclopropyl-4-{[3-(cyclopropylcarbamoyl)-2-(trifluoromethyl)phenyl]amino}-N-[imidazolidin-2-ylidene]benzamide, [0380] (117) 3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]-4-({3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)benzamide, [0381] (118) 4-{[2-chloro-5-fluoro-3-(morpholine-4-carbonyl)phenyl]amino}-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0382] (119) 3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]-4-{[3-(morpholine-4-carbonyl)phenyl]amino}benzamide, [0383] (120) 4-({2-chloro-3-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl]phenyl}amino)-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0384] (121) 4-({2-chloro-3-[2-(trifluoromethyl)morpholine-4-carbonyl]phenyl}amino)-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0385] (122) 4-({2-chloro-3-[3-(trifluoromethyl)morpholine-4-carbonyl]phenyl}amino)-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0386] (123) 3-chloro-2-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl }phenyl)amino]-N-(1-methylcyclopropyl)pyridine-4-carboxamide, [0387] (124) N-{3-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]phenyl}-1,1-dioxo-1λ.sup.6-thiane-4-carboxamide, [0388] (125) 3-fluoro-N-[imidazolidin-2-ylidene]-4-({3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-5-(oxolan-2-yl)benzamide, [0389] (126) 4-{[2-chloro-3-(morpholine-4-sulfonyl)phenyl]amino}-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0390] (127) 4-({3-[(1-cyanocyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]benzamide, [0391] (128) 3-cyclopropyl-5-fluoro-4-({3-fluoro-5-[(propan-2-yl)carbamoyl]phenyl}amino)-N-[imidazolidin-2-ylidene]benzamide, [0392] (129) 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]benzamide, [0393] (130) 3-cyclopropyl-5-fluoro-4-({2-fluoro-3-[(propan-2-yl)carbamoyl]phenyl}amino)-N-[imidazolidin-2-ylidene]benzamide, [0394] (131) 5-cyclopropyl-2-fluoro-N-[imidazolidin-2-ylidene]-4-({3-[(propan-2-yl)carbamoyl]phenyl}amino)benzamide, [0395] (132) 3-tert-butyl-4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-N-[imidazolidin-2-ylidene]benzamide, [0396] (133) 5-cyclopropyl-N-[imidazolidin-2-ylidene]-6-({3-[(propan-2-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide, [0397] (134) 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-fluoro-N-[imidazolidin-2-ylidene]-5-(oxolan-3-yl)benzamide, [0398] (135) 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-fluoro-N-[imidazolidin-2-ylidene]-5-(oxolan-2-yl)benzamide, [0399] (136) 3-chloro-2-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-(1-methylcyclopropyl)pyridine-4-carboxamide, [0400] (137) 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-N-[imidazolidin-2-ylidene]-3-(oxolan-2-yl)benzamide, [0401] (138) 3-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-2,5-difluoro-N-(propan-2-yl)benzamide, [0402] (139) 3-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-2,5-difluoro-N-(1-methylcyclopropyl)benzamide, [0403] (140) N-[imidazolidin-2-ylidene]-4-({3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-(oxolan-2-yl)benzamide, [0404] (141) 4-{[3-(1-cyanocyclopropaneamido)phenyl]amino}-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0405] (142) 3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]-4-({3-[3-(trifluoromethyl)morpholine-4-carbonyl]phenyl}amino)benzamide, [0406] (143) 3-cyclopropyl-5-fluoro-4-({2-fluoro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-N-[imidazolidin-2-ylidene]benzamide, [0407] (144) 3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]-({3-[2-(trifluoromethyl)morpholine-4-carbonyl]phenyl}amino)benzamide, [0408] (145) 3-fluoro-N-[imidazolidin-2-ylidene]-4-{[3-(morpholine-4-carbonyl)phenyl]amino}-5-(oxolan-2-yl)benzamide, [0409] (146) 6-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-5-cyclopropyl-N-[imidazolidin-2-ylidene]pyridine-3-carboxamide, [0410] (147) 2-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenypamino]-3-fluoro-N-(1-methylcyclopropyl)pyridine-4-carboxamide, [0411] (148) 2-cyclopropyl-3-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}phenypamino]-5-fluoro-N-(propan-2-yl)benzamide, [0412] (149) 3-cyano-5-cyclopropyl-N-[imidazolidin-2-ylidene]-4-({3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)benzamide, [0413] (150) 3-chloro-4-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-(1-methylcyclopropyl)pyridine-2-carboxamide, [0414] (151) 4-chloro-5-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-(1-methylcyclopropyl)pyridine-3-carboxamide [0415] (152) N-(1-cyanocyclopropyl)-2-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-3-fluoropyridine-4-carboxamide, [0416] (153) 4-{[3-chloro-4-(morpholine-4-carbonyl)pyridin-2-yl]amino}-3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]benzamide, [0417] (154) 4-({3-chloro-4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl]pyridin-2-yl}amino)-3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]benzamide, [0418] (155) 4-({3-chloro-4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl]pyridin-2-yl}amino)-3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]benzamide, [0419] (156) 3-cyclopropyl-5-fluoro-4-{[3-fluoro-4-(morpholine-4-carbonyl)pyridin-2-yl]amino}-N-[imidazolidin-2-ylidene]benzamide, [0420] (157) 3-chloro-4-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-(1-methylcyclopropyl)pyridine-2-carboxamide, [0421] (158) 3-cyclopropyl-5-fluoro-4-{[2-fluoro-3-(morpholine-4-carbonyl)phenyl]amino}-N-[imidazolidin-2-ylidene]benzamide, [0422] (159) 3-cyclopropyl-5-fluoro-4-({3-fluoro-4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl]pyridin-2-yl}amino)-N-[imidazolidin-2-ylidene]benzamide, [0423] (160) 3-cyclopropyl-4-({3-[2-(3-methylbut-2-en-1-yl)-2H-1,2,3,4-tetrazol-5-yl]phenyl}amino)-N-[1-methylimidazolidin-2-ylidene]benzamide, [0424] (161) N-{3-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}pheny)amino]phenyl}-3-methyloxetane-3-carboxamide, [0425] (162) 3-cyclopropyl-4-[(3-{[1-(hydroxymethyl)cyclopropyl]carbamoyl}phenypamino]-N-[imidazolidin-2-ylidene]benzamide, [0426] (163) N-{3-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]phenyl}-3-methyloxetane-3-carboxamide, [0427] (164) N-{bicyclo[1.1.1]pentan-2-yl}-3-chloro-2-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]pyridine-4-carboxamide, [0428] (165) 3-cyclopropyl-4-{[3-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]amino}-5-fluoro-N-[imidazolidin-2-ylidene]benzamide, [0429] (166) 3-chloro-2-[(2-cyclopropyl-6-fluoro-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-{3-fluorobicyclo[1.1.1]pentan-1-yl}pyridine-4-carboxamide, [0430] (167) 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide, [0431] (168) tert-butyl 2-{3-chloro-2-[(2-cyclopropyl-6-fluoro-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]pyridin-4-yl}-4,5-dihydro-1H-imidazole-1-carboxylate, [0432] (169) 3-cyclopropyl-4-{[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]amino}-5-fluoro-N-[(2Z)-imidazolidin-2-ylidene]henzamide, [0433] (170) 3-cyclopropyl-5-fluoro-N-[(2Z)-imidazolidin-2-ylidene]-4-{[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]amino}benzamide, [0434] (171) 3-cyclopropyl-5-fluoro-N-[(2Z)-imidazolidin-2-ylidene]-4-{[3-(thiomorpholine-4-carbonyl)phenyl]amino}benzamide, [0435] (172) 3-chloro-2-[(2-cyclopropyl-6-fluoro-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-[(1s,3R,5 S,7s)-adamantan-1-yl]pyridine-4-carboxamide, [0436] (173) 3-cyclopropyl-5-fluoro-N-[(2Z)-imidazolidin-2-ylidene]-4-[(3-{[(1s,3R,5S,7s)-adamantan-1-yl]carbamoyl}phenyl)amino]benzamide, [0437] (174) 3-cyclopropyl-5-fluoro-N-[(2E)-1-methylimidazolidin-2-ylidene]-4-[(3-{[(1s,3R,5S,7s)-adamantan-1-yl]carbamoyl}phenyl)amino]benzamide, [0438] (175) (R)—N-(3-((2-cyclopropyl-6-fluoro-4-(imidazolidin-2-ylidenecarbamoyl)phenyl)amino)phenyl)pyrrolidine-2-carboxamide, [0439] (176) 3-cyclopropyl-5-fluoro-N-[(2E)-1-methylimidazolidin-2-ylidene]-4-({3-[(oxetan-3-yl)carbamoyl]phenyl}amino)benzamide, [0440] (177) 3-cyclopropyl-5-fluoro-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(oxetan-3-yl)carbamoyl]phenyl}amino)benzamide, [0441] (178) 3-cyclopropyl-5-fluoro-N-[(2Z)-imidazolidin-2-ylidene]-4-({3-[(1,3-oxazol-2-yl)carbamoyl]phenyl}amino)benzamide, [0442] (179) (2R)—N-{3-[(2-cyclopropyl-6-fluoro-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenyl)amino]phenyl}-5-oxopyrrolidine-2-carboxamide, [0443] (180) N-{3-[(2-cyclopropyl-6-fluoro-4-{[(2Z)-imidazolidin-2-ylidene]carbamoyl}phenypamino]phenyl}-2-oxabicyclo[2. 1.1]hexane-1-carboxamide, [0444] (181) 4-({2-chloro-3-[(1-cyanocyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropyl-5-fluoro-N-[(2E)-imidazolidin-2-ylidene]benzamide, and their pharmaceutically acceptable salts.
[0445] The present invention therefore extends to compounds (1) to (181) and their pharmaceutically acceptable salts, such as hydrobromide, tartrate, citrate, trifluoroacetate, ascorbate, hydrochloride, tosylate, triflate, maleate, mesylate, formate, acetate and fumarate.
[0446] According to another aspect, a subject-matter of the present invention relates to compounds (1) to (181) or any of its pharmaceutically acceptable salts, for use as a medicament.
[0447] According to another aspect, a subject-matter of the present invention relates to a compound of formula (I) as defined above or any of its pharmaceutically acceptable salts, and any of compounds (1) to (181) or any of its pharmaceutically acceptable salts, for use as an agent for preventing, inhibiting or treating a RNA virus infection caused by a RNA virus belonging to group V of the Baltimore classification, and in particular a RSV viral infection or a virus-related condition.
[0448] The compounds of the invention may exist in the form of free bases or of addition salts with pharmaceutically acceptable acids.
[0449] «Pharmaceutically acceptable salt thereof» refers to salts which are foitiied from acid addition salts formed with inorganic acids (e.g. hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, and the like), as well as salts formed with organic acids such as acetic acid, oxalic acid, tartaric acid, succinic acid, malic acid, fumaric acid, maleic acid, ascorbic acid, benzoic acid, tannic acid, palmoic acid, alginic acid, polyglutamic acid, naphthalene sulfonic acid, naphthalene disulfonic acid, and poly-galacturonic acid.
[0450] Suitable physiologically acceptable acid addition salts of compounds of formula (I) include hydrobromide, tartrate, citrate, trifluoroacetate, ascorbate, hydrochloride, tosylate, triflate, maleate, mesylate, formate, acetate and fumarate.
[0451] The compounds of formula (I) and any of compounds (1) to (181) or any of their pharmaceutically acceptable salts may form solvates or hydrates and the invention includes all such solvates and hydrates.
[0452] The compounds of formula (I) may be present as well under tautomer forms and are part of the invention.The terms “hydrates” and “solvates” simply mean that the compounds (I) according to the invention can be in the form of a hydrate or solvate, i.e. combined or associated with one or more water or solvent molecules. This is only a chemical characteristic of such compounds, which can be applied for all organic compounds of this type.
[0453] In the context of the present invention, the term: [0454] “halogen” is understood to mean chlorine, fluorine, bromine, or iodine, and in particular denotes chlorine, fluorine or bromine, [0455] “(C.sub.1-C.sub.x)alkyl”, as used herein, respectively refers to a C.sub.1-C.sub.x normal, secondary or tertiary saturated hydrocarbon, for example (C.sub.1-C.sub.6)alkyl. Examples are, but are not limited to, methyl, ethyl, 1-propyl, 2-propyl, butyl, pentyl, [0456] an “alkenylene” means a divalent (C.sub.1-C.sub.x)alkyl group comprising a double bond, and more particularly a ethenylene group, also known as vinylene or 1,2-ethenediyl, [0457] “(C.sub.3-C.sub.6)cycloalkyl”, as used herein, refers to a cyclic saturated hydrocarbon. Examples are, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, [0458] “(C.sub.1-C.sub.x)alkoxy”, as used herein, refers to a O—(C.sub.1-C.sub.x)alkyl moiety, wherein alkyl is as defined above, for example (C.sub.1-C.sub.6)alkoxy. Examples are, but are not limited to, methoxy, ethoxy, 1-propoxy, 2-propoxy, butoxy, pentoxy, [0459] a “5- or 6-membered heterocyclic ring comprising 1, 2, 3 or 4 heteroatoms” as used herein, means an aromatic or non aromatic ring comprising 5 or 6 bonds and 1, 2, 3 or 4 heteroatoms selected from oxygen, sulfur and nitrogen atoms. In one particular embodiment, it is a “5-membered heterocyclic ring comprising 1, 2, 3 or 4 heteroatoms”. In one embodiment, it comprises at least 1 heteroatom, and preferably at least one nitrogen atom. In another embodiment, it comprises at least 2 heteroatoms, with for example at least one nitrogen atom. According to a further embodiment, it comprises 2, 3 or 4 nitrogen atoms. According to an even further embodiment, it comprises one nitrogen atom and one oxygen atom or two nitrogen atoms and one oxygen atom. Examples are, but not limited to, tetrazoles, triazoles, such as 1,2,3- or 1,2,4- triazoles, and diazoles, such as imidazole, pyrazole, 2- or 3-pyrazoline, dihydroimidazole or imidazoline, oxadiazoles, such as 1,2,4-oxadiazole or 1,2,3-oxadiazoles, oxazoles, oxazolines, oxazolidines, oxazolidinones. According to a preferred embodiment, such 5-membered heterocyclic ring comprising 2, 3 or 4 heteroatoms is a triazole, a tetrazole, an imidazoline or an oxazoline. In one embodiment, a 5-membered heteroaromatic ring may comprise one or two heteroatoms selected from a oxygen atom and a nitrogen atom, and may in particular be selected from a oxazolyl group, a isoxazolyl group, a pyrazolyl group and an imidazolyl group, [0460] a “bicyclic alkyl” or “(C.sub.5-C.sub.11)bicyclic alkyl” compound means a bicyclic saturated hydrocarbon monovalent group that may be chosen among spirocyclic alkyl, fused bicyclic alkyl and bridged bicyclic alkyl. Such bicyclic alkyl generally comprises 5 to 11 carbon atoms. Examples are, but are not limited to, spiro[2.2]pentyl, spiro[5.5]undecanyl, spiro[3.4]octanyl, spiro[4.5]decanyl, bicyclo[1.1.0]butyl, bicyclo[2.1.1]hexyl, bicyclo[3.2.0]heptyl, bicyclo[3.3.0]octyl, bicyclo[4.3.0]nonyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl, bicyclo[3.2.1]octyl, bicyclo[1.1.1]pentyl, oxabicyclo[1.1.1]pentyl, oxabicyclo[2.1.1]hexyl, oxabicyclo[2.2.1]heptyl, oxabicyclo[4.1.0]heptyl, oxabicyclo[3.2.1]octyl and cubyl, and [0461] a “bridged morpholinyl group” means a bicyclic compound where one of the cycles is a morpholinyl group, the two rings share three or more atoms and the bridge contains at least one atom, for example 1, 2 or three atoms. Examples are, but are not limited to, as depicted herein after:
##STR00024##
[0462] The compounds of formula (I) can comprise one or more asymmetric carbon atoms. They can thus exist in the form of enantiomers or of diastereoisomers. These enantiomers, diastereoisomers and their mixtures, including the racemic mixtures, are encompassed within the scope of the present invention.
[0463] The compounds of the present invention can be prepared by conventional methods of organic synthesis practiced by those skilled in the art. The general reaction sequences outlined below represent a general method useful for preparing the compounds of the present invention and are not meant to be limiting in scope or utility.
[0464] The compounds of general formula (I) when Q is NF1 can be prepared according to scheme 1 below.
##STR00025##
[0465] The synthesis is based on a coupling reaction of a halogeno aromatic compound of formula (III) with an aniline derivative (II), wherein R, R′, R.sub.c, R.sub.g, R.sub.h, m, m′,
##STR00026##
ring,
##STR00027##
ring, X.sup.2, n, Y.sup.2 are as defined above and X is a chlorine atom, an iodine atom or a bromine atom, following procedure (A1) or (A2), followed by at least a further step reacting the carboxylic acid derivative of the compound obtained after said coupling step with a compound of formula
##STR00028##
wherein Z″, R.sub.g and R.sub.h are as defined above. In the case where R.sub.g=R.sub.h═H and Z″ is —CO—, the procedure may consist firstly in reacting compound (V) with guanidine and secondly in a cyclisation step to afford final cyclised derivative (I) where R.sub.g═R.sub.h═H and Z″ is —CO—.
[0466] According to one embodiment, procedure (A1) may advantageously be used when the group
##STR00029##
is in meta or para position on the
##STR00030##
ring, with respect to the —NH— group.
[0467] According to procedure (A1), the compound of formula (III) may be placed in a protic solvent such as tert-butanol. The compound of foiniula (II) may then be added, for example in a molar ratio ranging from 1 to 1.5 with respect to the compound of formula (III) in presence of an inorganic base, such as Cs.sub.2CO.sub.3 or K.sub.2CO.sub.3, for example in a molar ratio ranging from 1 to 5 still with respect to the compound of formula (III), in the presence of a diphosphine, such as Xantphos (4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene) or X-Phos (2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl) or rac-BINAP in particular in an amount ranging from 2 mol % to 15 mol % relative to the total amount of compound of formula (III), and in the presence of an organometallic catalyst, such as Pd(OAc).sub.2 or Pd.sub.2dba.sub.3, or BrettPhos Pd G3 in an amount ranging from 2 mol % to 25 mol % relative to the total amount of compound of formula (III). The reaction mixture can then be heated at a temperature ranging from 80 to 130° C., for example at 90° C., and stirred for a time ranging from 15 to 25 hours, for example during 20 hours, under inert gas and for example argon. The reaction mixture can be concentrated under reduced pressure and the residue can be diluted with an organic solvent such as ethyl acetate. The organic phase can be washed with water, decanted, dried over magnesium sulphate, filtered and then concentrated under reduced pressure to give a compound of formula (IV).
[0468] According to one embodiment, procedure (A2) may advantageously be used when the group
##STR00031##
is in ortho position on the
##STR00032##
ring, with respect to the —NH— group.
[0469] According to procedure (A2), the compound of formula (II) may be placed in a polar aprotic solvent such as dimethylsulfoxide. The compound of formula (III) may then be added, for example in a molar ratio ranging from 1 to 1.5 with respect to the compound of formula (II) in presence of an inorganic base, such as Cs.sub.2CO.sub.3 or K.sub.2CO.sub.3, for example in a molar ratio ranging from 1 to 5 still with respect to the compound of formula (II), in the presence of a ligand, such as L-proline in particular in an amount ranging from 2 mol % to 25 mol % relative to the total amount of compound of formula (II), and in the presence of an organometallic catalyst, such as CuI, in an amount ranging from 2 mol % to 25 mol % relative to the total amount of compound of formula (II). The reaction mixture can then be heated at a temperature ranging from 80 to 130° C., for example at 90° C., and stirred for a time ranging from 15 to 25 hours, for example during 20 hours, under inert gas and for example argon. The reaction mixture can be diluted with an organic solvent such as ethyl acetate. The organic phase can be washed with water, decanted, dried over magnesium sulphate, filtered and then concentrated under reduced pressure to give a compound of formula (IV).
[0470] The starting compounds of formula (II), (III) are available or can be prepared according to methods known to the person skilled in the art. In particular, the method used to afford the building block of formula (III) which further leads to compound (166) is based on the synthesis of intermediate (3-fluorobicyclo[1.1.1]pentan-1-aminium chloride) described in Org. Biomol. Chem. 2015, 13, 11597-11601. In addition, the method used to afford the building block of formula (III) which further leads to compound (180) is based on the synthesis of intei mediate (2-oxabicyclo[2.1.1]hexane-1-carboxylic acid) described in Angew. Chem. Int. Ed. 2020, 59, 7161-7167. In addition, the method used to afford the required building blocks of formula (III) which further lead to compounds (165), (168) and (169) is based on the method described in Synlett 2006, 10, 1479-1484.
[0471] Accordingly, the present invention further relates to the synthesis process for manufacturing new compounds of formula (I) as defined above, when Q is NH, comprising at least [0472] (i) a step of coupling a compound of formula (II)
##STR00033##
with a compound of formula (III)
##STR00034##
wherein R, R′, m, m′, n,
##STR00035##
ring,
##STR00036##
ring, X.sup.2, Y.sup.2 are as defined above, R.sub.c is an alkyl group, such as a ethyl or methyl group and X is a chlorine atom, an iodine atom or a bromine atom, in presence of an inorganic base and a ligand and in the presence of an organometallic catalyst, to obtain a compound of formula (IV)
##STR00037##
wherein R.sub.c means an alkyl group, such as an ethyl group or a methyl group, preferentially a methyl group and R, R′, m, m′, n,
##STR00038##
ring,
##STR00039##
ring, X.sup.2, Y.sup.2 are as defined above, followed by a hydrolysis leading to a compound of formula
##STR00040##
wherein R.sub.c is a hydrogen atom and R, R′, m, m′, n,
##STR00041##
ring,
##STR00042##
ring, X.sup.2, Y.sup.2 are as defined above, and
[0473] (ii) a step of reacting a compound of formula (V) with a compound of formula
##STR00043##
wherein Z″, R.sub.g and R.sub.h are as defined above in presence of an organic base such as N,N-diisopropylethylamine and in presence of a coupling agent such as 1,1′-carbonyldiimidazole, to obtain a compound for formula (I) wherein Q is NH, as defined above.
[0474] The compounds of general formula (I) when Q is O can be prepared according to scheme 1′ below.
##STR00044##
[0475] The synthesis is based on a coupling reaction starting from a halogeno aromatic compound of formula (III) with a phenol derivative of formula (II'), wherein R, R′, R.sub.g, R.sub.h, Z″, m, m′,
##STR00045##
ring,
##STR00046##
ring, X.sup.2, n, Y.sup.2 are as defined above and X is a fluorine atom.
[0476] According to procedure (D), the fluoroaryl derivative (III) may be placed in a polar solvent such as N,N-dimethylformamide. Phenol derivative (II′) may then be added in a molar ratio ranging from 1 to 2 with respect to the fluoroaryl derivative (III) in presence of an inorganic base, such as Cs.sub.2CO.sub.3 or K.sub.2CO.sub.3, in particular in a molar ratio ranging from 1 to 5. The reaction mixture can then be heated at a temperature ranging from 50 to 150° C., for example at 70° C. and stirred for a time ranging from 5 to 90 hours, for example during 16 hours, under inert gas and for example argon. The reaction mixture can be concentrated under reduced pressure and the residue can be partitioned between an organic solvent, such as dichloromethane, and water. The organic phase can be washed with water, decanted, dried over magnesium sulphate, filtered, concentrated under reduced pressure and purified to give a compound of formula (IV′).
[0477] Accordingly, the present invention further relates to the synthesis process for manufacturing new compounds of formula (I) as defined above, wherein Q is O, comprising [0478] (i) at least a step of coupling a compound of formula (II′)
##STR00047##
with a compound of formula (III)
##STR00048##
wherein R, R′, R.sub.c, R.sub.h, R.sub.g, m, m′, n,
##STR00049##
ring,
##STR00050##
ring, X.sup.2, Y.sup.2 are as defined above and X is a fluorine atom, in presence of an inorganic base, to obtain a compound of formula (IV′)
##STR00051##
wherein R.sub.c means an alkyl group, such as an ethyl group or a methyl group, preferentially a methyl group and R, R′, m, m′, n,
##STR00052##
ring,
##STR00053##
ring, X.sup.2, Y.sup.2 are as defined above, followed by a hydrolysis leading to a compound of formula
##STR00054##
wherein R.sub.c is a hydrogen atom and R, R′, m, m′, n,
##STR00055##
ring,
##STR00056##
ring, X.sup.2, Y.sup.2 are as defined above, and [0479] (ii) a step of reacting a compound of formula (V′) with a compound or formula
##STR00057##
[0480] wherein R.sub.g and R.sub.h are as defined above, wherein Q is O, as defined above.
[0481] The starting compounds of formula (II), (II′), (III) are available or can be prepared according to methods known to the person skilled in the art.
[0482] More particularly, compounds of formula (II), when used to prepare compounds of formula (I), can be prepared according to scheme 2 below.
##STR00058##
[0483] According to procedure (E), the compound of formula (VI) and an organometallic catalyst such as Pd(dppf)Cl.sub.2. CH.sub.2Cl.sub.2 or Pd(OAc).sub.2 in an amount ranging from 2 mol % to 20 mol % relative to the amount of the compound of foi tnula (VI) may be placed in a solvent such as 1,4-dioxane or a solvent mixture such as toluene and water. A boronic acid R.sup.1′—B(OH).sub.2 or an organotrifluoroborate derivative R.sup.1′—BF.sub.3K may then be added in a molar ratio ranging from 1 to 5 with respect to the compound of formula (VI), in presence of an inorganic base, such as K.sub.2CO.sub.3 or K.sub.3PO.sub.4, in particular in a molar ratio ranging from 2 to 5, and in presence of a ligand, such as RuPhos, in particular in a molar ratio ranging from 2 to 5. The reaction mixture can then be heated at a temperature ranging from 50 to 150° C., for example at 110° C., and stirred for a time ranging from 2 to 70 hours, for example during 3 hours, under inert gas and for example argon. The reaction mixture can be concentrated under reduced pressure and purified to give a compound of formula (II).
[0484] More particularly, compounds of formula (II'), when used to prepare compounds of formula (I), can be prepared with a procedure similar to procedure (E) described above.
[0485] The chemical structures and spectroscopic data of some compounds of formula (I) of the invention are illustrated respectively in the following Table I and Table II.
TABLE-US-00001 TABLE I
TABLE-US-00002 TABLE II No Characterizations 1 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.38 (s, 1H), 8.09 (s, 2H), 7.79 (dd, J = 1.9, 8.4 Hz, 1H), 7.76 (s, 1H), 7.72 (d, J = 1.9 Hz, 1H), 7.53-7.49 (m, 1H), 7.31-7.26 (m, 2H), 7.21-7.15 (m, 1H), 7.11 (d, J = 8.5 Hz, 1H), 3.52 (s, 4H), 1.98-1.90 (m, 1H), 1.71-1.62 (m, 1H), 0.98-0.92 (m, 2H), 0.90 (d, J = 6.8 Hz, 6H), 0.70-0.65 (m, 4H), 0.61-0.55 (m, 2H). [M + H].sup.+ = 446.2 2 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.64 (s, 1H), 8.12 (s, 2H), 8.03 (d, J = 1.9 Hz, 1H), 7.80 (dd, J = 8.4, 1.9 Hz, 1H), 7.51 (s, 1H), 7.33 (s, 1H), 7.16-7.05 (m, 2H), 7.02 (d, J = 8.4 Hz, 1H), 6.63 (d, J = 7.9 Hz, 1H), 3.53 (s, 4H), 3.29 (s, 1H), 2.61-2.52 (m, 1H), 2.00 (d, J = 8.0 Hz, 2H), 1.84-1.71 (m, 2H), 1.64 (dd, J = 7.2, 4.7 Hz, 2H), 1.55-1.41 (m, 2H), 1.07 (d, J = 6.8 Hz, 6H). [M + H].sup.+ = 434.0 3 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.14 (s, 2H), 8.08 (s, 1H), 7.85 (d, J = 8.5 Hz, 1H), 7.29 (s, 1H), 7.20 (t, J = 7.8 Hz, 1H), 6.96 (d, J = 8.3 Hz, 1H), 6.78 (s, 2H), 3.66 (s, 4H), 3.56 (t, J = 4.7 Hz, 2H), 3.53 (s, 4H), 3.23 (d, J = 8.3 Hz, 1H), 3.19 (d, J = 5.1 Hz, 2H), 1.99 (s, 2H), 1.76 (s, 2H), 1.60 (d, J = 4.8 Hz, 2H), 1.52 (s, 2H). [M + H].sup.+ = 496.0 4 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (s, 2H), 7.83 (d, J = 8.7 Hz, 1H), 7.77 (s, 1H), 7.44 (s, 1H), 7.31 (s, 1H), 7.13 (s, 1H), 7.03 (s, 1H), 6.92 (s, 1H), 3.67 (s, 4H), 3.61-3.49 (m, 6H), 3.20 (d, J = 5.5 Hz, 2H), 1.90 (d, J = 10.4 Hz, 1H), 0.95 (d, J = 8.3 Hz, 2H), 0.61 (s, 2H). [M + H].sup.+ = 468.0 5 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8 9.61 (s, 1H), 8.18 (s, 1H), 8.13 (s, 2H), 7.86 (d, J = 8.1 Hz, 1H), 7.11 (d, J = 8.2 Hz, 1H), 7.01 (dd, J = 14.6, 6.9 Hz, 4H), 6.45 (d, J = 7.7 Hz, 1H), 3.54 (s, 4H), 2.26-2.20 (m, 2H), 1.52 (dd, J = 13.2, 6.4 Hz, 1H), 1.47-1.42 (m, 2H), 1.39 (s, 9H), 0.87 (d, J = 6.5 Hz, 6H). [M + H].sup.+ = 450.2 6 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.21 (d, J = 1.9 Hz, 1H), 8.13 (s, 2H), 7.95 (d, J = 8.5 Hz, 1H), 7.87 (dd, J = 8.2, 1.9 Hz, 1H), 7.25-7.21 (m, 1H), 7.21-7.06 (m, 4H), 6.81-6.76 (m, 1H), 4.16- 3.99 (m, 1H), 3.53 (s, 4H), 1.63-1.46 (m, 2H), 1.39 (s, 9H), 1.22 (ddd, J = 13.5, 8.3, 5.4 Hz, 1H), 1.09 (d, J = 6.6 Hz, 3H), 0.87 (dd, J = 6.5, 1.9 Hz, 6H). [M + H].sup.+ = 464.3 7 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.14 (t, J = 5.5 Hz, 1H), 8.08 (s, 2H), 7.82 (d, J = 8.5 Hz, 2H), 7.26-7.15 (m, 3H), 7.03 (d, J = 8.2 Hz, 1H), 6.84 (d, J = 6.2 Hz, 1H), 3.51 (s, 4H), 3.25 (q, J = 6.5 Hz, 2H), 1.96-1.78 (m, 2H), 1.67 (dp, J = 13.3, 6.7 Hz, 1H), 1.43 (q, J = 7.0 Hz, 2H), 1.04-0.95 (m, 2H), 0.92 (d, J = 6.6 Hz, 6H), 0.87 (d, J = 8.6 Hz, 2H), 0.62 (q, J = 5.4 Hz, 2H), 0.45 (q, J = 5.4 Hz, 2H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.7, 169.6, 165.7, 145.6, 143.1, 141.8, 130.6, 129.6, 129.0, 128.7, 128.2, 127.1, 120.5, 119.0, 114.2, 41.7, 38.4, 37.7, 25.8, 22.9, 11.9, 11.0, 7.27, 6.5 [M + H].sup.+ = 474.2 8 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.21 (d, J = 8.0 Hz, 2H), 8.14 (s, 2H), 7.87 (d, J = 8.3 Hz, 1H), 7.23-7.09 (m, 5H), 6.83 (s, 1H), 3.54 (s, 4H), 3.23 (q, J = 6.5 Hz, 2H), 1.60 (dt, J = 13.6, 6.8 Hz, 1H), 1.40 (s, 11H), 0.89 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 450.2 9 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.21 (d, J = 1.9 Hz, 1H), 8.12 (s, 2H), 7.87 (dd, J = 8.2, 1.9 Hz, 1H), 7.09 (dt, J = 7.8, 3.7 Hz, 2H), 6.67 (dd, J = 8.2, 1.1 Hz, 1H), 6.60 (dd, J = 7.5, 1.1 Hz, 1H), 6.55 (s, 1H), 3.77-3.47 (m, 10H), 3.26 (dt, J = 7.1, 4.3 Hz, 2H), 1.77 (ddd, J = 14.0, 8.3, 5.8 Hz, 1H), 1.43 (s, 9H), 1.00-0.89 (m, 2H), 0.69 (s, 1H), 0.34 (dd, J = 8.9, 4.0 Hz, 1H). [M + H].sup.+ = 490.3 10 .sup.1H NMR (500 MHz, d.sub.6-DMSO) δ 8.36 (t, J = 5.7 Hz, 1H), 8.10 (s, 2H), 7.87-7.77 (m, 2H), 7.32 (s, 1H), 7.27-7.20 (m, 1H), 7.10 (dd, J = 8.2, 1.4 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 6.88 (dd, J = 7.4, 1.5 Hz, 1H), 3.52 (s, 4H), 3.27-3.20 (m, 2H), 1.87 (ddd, J = 13.7, 8.3, 5.4 Hz, 1H), 1.68 (dp, J = 13.4, 6.7 Hz, 1H), 1.41 (q, J = 7.0 Hz, 2H), 0.98-0.88 (m, 8H), 0.63-0.56 (m, 2H). [M + H].sup.+ = 468.1 11 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.28 (d, J = 7.8 Hz, 1H), 8.11 (s, 2H), 7.85 (dd, J = 8.3, 1.9 Hz, 1H), 7.80 (d, J = 1.8 Hz, 1H), 7.32 (s, 1H), 7.28-7.20 (m, 1H), 7.10 (dd, J = 8.2, 1.5 Hz, 1H), 7.05 (d, J = 8.3 Hz, 1H), 6.89 (dd, J = 7.4, 1.5 Hz, 1H), 4.05 (d, J = 7.7 Hz, 1H), 3.52 (s, 4H), 1.94- 1.82 (m, 1H), 1.15 (d, J = 6.6 Hz, 6H), 0.99-0.90 (m, 2H), 0.65-0.57 (m, 2H). [M + H].sup.+ = 440.0 12 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 7.83 (dd, J = 8.3, 1.9 Hz, 1H), 7.80 (d, J = 1.8 Hz, 1H), 7.21 (s, 1H), 7.17 (t, J = 8.3 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 6.81-6.75 (m, 1H), 6.75- 6.69 (m, 1H), 4.19-4.08 (m, 2H), 3.80 (dd, J = 11.4, 2.5 Hz, 1H), 3.76-3.70 (m, 2H), 3.65 (d, J = 11.2 Hz, 1H), 3.56 (dd, J = 11.4, 2.4 Hz, 1H), 3.52 (s, 4H), 3.47 (id, J = 11.0, 2.6 Hz, 1H), 3.27 (dd, J = 11.4, 9.9 Hz, 1H), 1.92-1.82 (m, 2H), 1.79 (dd, J = 13.8, 8.2 Hz, 1H), 0.98-0.92 (m, 2H), 0.62-0.56 (m, 2H). [M + H].sup.+ = 485.0 13 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 10.05 (s, 1H), 8.10 (s, 2H), 7.78 (dd, J = 8.4, 2.0 Hz, 1H), 7.70 (d, J = 1.9 Hz, 1H), 7.62 (s, 1H), 7.44 (s, 1H), 7.17-7.10 (m, 2H), 7.08 (s, 1H), 6.75 (d, J = 8.9 Hz, 1H), 3.52 (s, 4H), 1.96 (ddd, J = 13.7, 8.3, 5.3 Hz, 1H), 1.81-1.70 (m, 1H), 0.99-0.89 (m, 2H), 0.76 (dt, J = 8.6, 2.5 Hz, 4H), 0.61-0.52 (m, 2H). [M + H].sup.+ = 404.0 14 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.53 (s, 1H), 8.11 (s, 2H), 7.79 (dd, J = 8.4, 1.9 Hz, 2H), 7.72 (d, J = 1.8 Hz, 1H), 7.52 (s, 1H), 7.28 (d, J = 5.0 Hz, 2H), 7.22-7.14 (m, 1H), 7.11 (d, J = 8.4 Hz, 1H), 3.52 (s, 4H), 1.94 (ddd, J = 13.8, 8.3, 5.4 Hz, 1H), 1.35 (s, 3H), 0.98-0.91 (m, 2H), 0.75- 0.68 (m, 2H), 0.58 (td, J = 6.3, 4.3 Hz, 4H). [M + H].sup.+ = 418.0 15 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (s, 2H), 8.08 (d, J = 1.9 Hz, 1H), 7.88 (dd, J = 8.3, 1.8 Hz, 1H), 7.47 (s, 1H), 7.24-7.17 (m, 1H), 6.98 (d, J = 7.7 Hz, 1H), 6.81 (dd, J = 7.5, 1.3 Hz, 1H), 6.74 (dd, J = 8.2, 1.4 Hz, 1H), 3.95 (td, J = 8.7, 8.3, 4.9 Hz, 2H), 3.74 (t, J = 7.6 Hz, 1H), 3.66 (s, 4H), 3.61 (dt, J = 5.3, 3.3 Hz, 2H), 3.56 (t, J = 4.9 Hz, 2H), 3.53 (s, 4H), 3.23-3.14 (m, 2H), 2.28 (dd, J = 11.9, 7.0 Hz, 1H), 1.93-1.83 (m, 1H). [M + H].sup.+ = 497.9 16 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.35 (d, J = 1.9 Hz, 1H), 8.17 (s, 2H), 8.10 (d, J = 8.6 Hz, 1H), 7.56 (s, 1H), 7.43-7.37 (m, 1H), 7.30 (dd, J = 8.1, 1.6 Hz, 1H), 7.13 (dd, J = 7.5, 1.6 Hz, 1H), 6.88 (d, J = 8.6 Hz, 1H), 3.66 (d, J = 2.7 Hz, 4H), 3.57-3.54 (m, 2H), 3.53 (s, 4H), 3.18 (d, J = 3.3 Hz, 2H). [M + H].sup.+ = 495.9 17 .sup.1H NMR (500 MHz, d.sub.6-DMSO) δ 8.64 (s, 1 H), 8.28 (d, J = 2.2 Hz, 1 H), 8.04 (d, J = 8.0 Hz, 1 H), 7.94 (dd, J = 8.2, 1.9 Hz, 1 H), 7.23 (t, J = 1.9 Hz, 1 H), 7.20-7.17 (m, 1 H), 7.17-7.15 (m, 1 H), 7.14-7.12 (m, 1H), 7.11 (d, J = 8.0 Hz, 1 H), 6.85-6.76 (m, 1 H), 4.13-3.97 (m, 1 H), 3.62- 3.51 (m, 2H), 3.49-3.41 (m, 2 H), 2.95 (s, 3 H), 1.39 (s, 9 H), 1.13 (d, J = 6.6 Hz, 6 H). [M + H].sup.+ = 436.5 18 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.52 (s, 1H), 8.12 (s, 2H), 8.02 (d, J = 1.8 Hz, 1H), 7.82 (dd, J = 8.4, 1.9 Hz, 1H), 7.48 (s, 1H), 7.43-7.37 (m, 1H), 7.22 (s, 2H), 7.13-7.02 (m, 2H), 3.70 (q, J = 8.5 Hz, 1H), 3.53 (s, 4H), 2.39-2.28 (m, 2H), 2.05-1.86 (m, 3H), 1.82-1.74 (m, 1H), 1.35 (s, 3H), 0.75-0.67 (m, 2H), 0.62-0.54 (m, 2H). [M + H].sup.+ = 432.0 19 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.20 (d, J = 1.7 Hz, 1H), 8.13 (s, 2H), 8.03 (d, J = 7.7 Hz, 1H), 7.87 (dd, J = 8.2, 1.8 Hz, 1H), 7.24 (s, 1H), 7.16 (t, J = 6.0 Hz, 3H), 7.10 (d, J = 8.2 Hz, 1H), 6.80 (s, 1H), 4.11-4.00 (m, 1H), 3.54 (s, 4H), 1.39 (s, 9H), 1.14 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 422.1 20 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.96 (s, 1H), 8.25-8.04 (m, 3H), 7.87 (dd, J = 8.2, 1.9 Hz, 1H), 7.17-6.96 (m, 4H), 6.92 (s, 1H), 6.47 (dt, J = 7.2, 2.0 Hz, 1H), 3.53 (s, 4H), 1.40 (s, 9H), 1.18 (s, 9H). [M + H].sup.+ = 436.3 21 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 7.80 (s, 2H), 7.22 (s, 1H), 7.17 (t, J = 8.3 Hz, 1H), 7.03 (d, J = 8.3 Hz, 1H), 6.77 (d, J = 8.2 Hz, 1H), 6.73 (d, J = 8.2 Hz, 1H), 4.06 (qd, J = 10.5, 4.8 Hz, 2H), 3.96-3.83 (m, 2H), 3.83-3.75 (m, 1H), 3.72-3.60 (m, 2H), 3.49 (q, J = 11.7, 10.6 Hz, 6H), 1.87 (ddd, J = 13.8, 8.4, 5.5 Hz, 1H), 0.99-0.90 (m, 2H), 0.59 (q, J = 5.6 Hz, 2H). [M + H].sup.+ = 418.3 22 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.08 (s, 2H), 7.78 (dd, J = 8.4, 1.9 Hz, 1H), 7.70 (d, J = 1.9 Hz, 1H), 7.58 (s, 1H), 7.17-7.07 (m, 2H), 6.65 (dd, J = 8.0, 1.5 Hz, 1H), 6.61 (t, J = 2.1 Hz, 1H), 6.42 (dd, J = 8.0, 2.1 Hz, 1H), 3.89 (t, J = 6.5 Hz, 2H), 3.51 (s, 4H), 1.94 (ddd, J = 13.7, 8.4, 5.4 Hz, 1H), 1.67 (dd, J = 18.2, 8.9 Hz, 7H), 1.31-1.12 (m, 6H), 0.96-0.81 (m, 4H), 0.61-0.52 (m, 2H). [M + H].sup.+ = 461.2 23 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 7.80 (s, 2H), 7.22 (s, 1H), 7.17 (t, J = 8.3 Hz, 1H), 7.03 (d, J = 8.3 Hz, 1H), 6.77 (d, J = 8.2 Hz, 1H), 6.73 (d, J = 8.2 Hz, 1H), 4.06 (qd, J = 10.5, 4.8 Hz, 2H), 3.96-3.83 (m, 2H), 3.83-3.75 (m, 1H), 3.72-3.60 (m, 2H), 3.49 (q, J = 11.7, 10.6 Hz, 6H), 1.87 (ddd, J = 13.8, 8.4, 5.5 Hz, 1H), 0.99-0.90 (m, 2H), 0.59 (q, J = 5.6 Hz, 2H). [M + H].sup.+ = 471.0 24 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.66 (s, 1H), 8.48 (s, 1H), 8.31 (d, J = 1.9 Hz, 1H), 7.96 (dd, J = 8.1, 1.9 Hz, 1H), 7.25-7.05 (m, 5H), 6.83 (dd, J = 1.1, 2.3 Hz, 1H), 3.68-3.53 (m, 2H), 3.52- 3.42 (m, 2H), 2.97 (s, 3H), 1.41 (s, 9H), 1.35 (s, 3H), 0.75-0.68 (m, 2H), 0.61-0.56 (m, 2H). [M + H].sup.+ = 448.2 25 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.45 (d, J = 4.5 Hz, 1H), 8.11 (s, 2H), 7.85 (dd, J = 8.3, 1.9 Hz, 1H), 7.79 (d, J = 1.8 Hz, 1H), 7.33 (s, 1H), 7.23 (s, 1H), 7.10 (d, J = 1.5 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 6.92-6.85 (m, 1H), 3.52 (s, 4H), 2.87-2.79 (m, 1H), 1.87 (s, 1H), 0.98-0.91 (m, 2H), 0.70 (td, J = 7.1, 4.8 Hz, 2H), 0.60 (dd, J = 5.5, 1.8 Hz, 2H), 0.56-0.50 (m, 2H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.5, 168.1, 165.8, 144.0, 140.9, 138.9, 132.9, 132.6, 127.9, 127.8, 120.3, 119.5, 118.8, 118.1, 41.7, 23.1, 11.7, 7.3, 6.1 [M + H].sup.+ = 438.0 26 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.68 (s, 1H), 8.08 (s, 2H), 7.79 (dd, J = 8.4, 1.9 Hz, 1H), 7.71 (d, J = 1.9 Hz, 1H), 7.60 (s, 1H), 7.45 (d, J = 1.8 Hz, 1H), 7.19-7.05 (m, 3H), 6.75 (d, J = 8.3 Hz, 1H), 3.51 (s, 4H), 2.64-2.52 (m, 1H), 1.95 (tt, J = 8.4, 5.4 Hz, 1H), 1.08 (d, J = 6.8 Hz, 6H), 0.99- 0.89 (m, 2H), 0.61-0.52 (m, 2H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.6, 146.1, 144.0, 140.6, 131.1, 129.5, 127.8, 127.5, 116.0, 114.2, 112.2, 109.9, 41.9, 35.3, 19.9, 11.6, 7.6 [M + H].sup.+ = 406.1 27 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.22 (t, J = 5.7 Hz, 1H), 8.10 (s, 2H), 7.83 (s, 2H), 7.26 (s, 2H), 7.14-7.01 (m, 3H), 3.74 (s, 3H), 3.52 (s, 4H), 3.30-3.23 (m, 2H), 1.89 (ddd, J = 13.7, 8.2, 5.3 Hz, 1H), 1.66 (dp, J = 13.4, 6.7 Hz, 1H), 1.43 (q, J = 7.0 Hz, 2H), 1.03-0.95 (m, 2H), 0.92 (d, J = 6.6 Hz, 6H), 0.65-0.56 (m, 2H). [M + H].sup.+ = 464.2 28 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.67 (d, J = 6.7 Hz, 1H), 8.11 (s, 2H), 7.84 (s, 1H), 7.80 (s, 1H), 7.34 (s, 1H), 7.29-7.20 (m, 1H), 7.13-7.08 (m, 1H), 7.05 (d, J = 8.4 Hz, 1H), 6.91 (dd, J = 7.4, 1.5 Hz, 1H), 4.42 (s, 1H), 3.87 (dd, J = 8.9, 6.2 Hz, 1H), 3.80 (t, J = 7.6 Hz, 1H), 3.71 (d, J = 5.5 Hz, 1H), 3.59 (dd, J = 8.9, 4.1 Hz, 1H), 3.52 (s, 4H), 2.15 (dd, J = 12.8, 7.6 Hz, 1H), 1.87 (s, 2H), 0.95 (dd, J = 8.3, 2.0 Hz, 2H), 0.61 (d, J = 3.6 Hz, 2H). [M + H].sup.+ = 468.0 29 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.27 (t, J = 5.7 Hz, 1H), 8.11 (s, 2H), 7.91 (d, J = 1.9 Hz, 1H), 7.88 (dd, J = 8.4, 2.0 Hz, 1H), 7.57 (s, 1H), 7.48 (s, 1H), 7.27 (d, J = 5.1 Hz, 2H), 7.16 (d, J = 8.5 Hz, 1H), 7.14 (d, J = 3.7 Hz, 1H), 5.19 (s, 1H), 5.04 (s, 1H), 3.52 (s, 4H), 3.29-3.21 (m, 2H), 2.00 (s, 3H), 1.61 (dp, J = 13.0, 6.9 Hz, 1H), 1.40 (q, J = 7.0 Hz, 2H), 0.90 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 434.3 30 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.32 (s, 1H), 8.11 (s, 2H), 8.05 (d, J = 1.9 Hz, 1H), 7.89 (dd, J = 8.4, 1.9 Hz, 1H), 7.53 (t, J = 7.9 Hz, 1H), 7.45 (d, J = 8.4 Hz, 1H), 7.19 (d, J = 8.4 Hz, 1H), 6.87 (d, J = 7.3 Hz, 1H), 5.96 (s, 1H), 3.70-3.46 (m, 10H), 3.28-3.19 (m, 1H), 3.14 (dq, J = 10.1, 3.4 Hz, 1H), 1.56 (d, J = 11.9 Hz, 6H). [M + H].sup.+ = 520.0 31 .sup.1H NMR (400 MHz, .sub.d6-DMSO) δ 8.48 (s, 1H), 8.09 (s, 2H), 7.83-7.73 (m, 2H), 7.71 (d, J = 1.8 Hz, 1H), 7.54-7.48 (m, 1H), 7.33-7.24 (m, 2H), 7.20-7.14 (m, 1H), 7.10 (d, J = 8.4 Hz, 1H), 3.51 (s, 4H), 1.99-1.89 (m, 1H), 1.59 (q, J = 7.5 Hz, 2H), 0.97-0.91 (m, 2H), 0.89 (t, J = 7.4 Hz, 3H), 0.72-0.65 (m, 2H), 0.63-0.53 (m, 4H). [M + H].sup.+ = 432.2 32 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.19 (d, J = 7.7 Hz, 1H), 8.15-8.07 (m, 3H), 7.83 (dd, J = 2.0, 8.4 Hz, 1H), 7.71 (d, J = 2.0 Hz, 1H), 7.33 (t, J = 1.7 Hz, 1H), 7.19 (d, J = 8.4 Hz, 1H), 7.09-7.01 (m, 1H), 6.84 (td, J = 2.2, 11.3 Hz, 1H), 4.12-3.96 (m, 1H), 3.52 (s, 4H), 2.00-1.89 (m, 1H), 1.15 (d, J = 6.6 Hz, 6H), 1.00-0.89 (m, 2H), 0.62-0.56 (m, 2H). [M + H].sup.+ = 424.1 33 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.26 (t, J = 5.7 Hz, 1H), 8.21 (d, J = 1.7 Hz, 1H), 8.13 (s, 2H), 7.88 (dd, J = 8.1, 1.6 Hz, 1H), 7.19 (dd, J = 14.4, 6.0 Hz, 3H), 7.11 (dd, J = 7.9, 4.2 Hz, 2H), 6.81 (d, J = 7.6 Hz, 1H), 3.75 (t, J = 11.7 Hz, 2H), 3.53 (s, 4H), 3.30-3.17 (m, 3H), 2.98 (t, J = 10.4 Hz, 1H), 1.83 (d, J = 12.6 Hz, 1H), 1.58-1.45 (m, 3H), 1.39 (s, 9H), 1.38-1.28 (m, 2H), 1.12 (qd, J = 11.2, 4.4 Hz, 1H). [M + H].sup.+ = 492.1 34 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 10.04-9.95 (m, 1H), 8.08 (s, 2H), 7.86-7.76 (m, 2H), 7.71 (d, J = 1.9 Hz, 1H), 7.42 (t, J = 1.9 Hz, 1H), 7.30-7.21 (m, 1H), 7.17-7.06 (m, 3H), 4.76-4.58 (m, 1H), 3.51 (s, 4H), 2.01-1.91 (m, 1H), 1.24 (d, J = 6.6 Hz, 6H), 1.00-0.91 (m, 2H), 0.64-0.52 (m, 2H). [M + H].sup.+ = 422.1 35 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.21 (d, J = 1.8 Hz, 2H), 8.13 (s, 2H), 7.88 (dd, J = 8.1, 1.8 Hz, 1H), 7.24-7.13 (m, 3H), 7.10 (d, J = 8.2 Hz, 2H), 6.82 (d, J = 9.5 Hz, 1H), 3.83 (d, J = 10.7 Hz, 1H), 3.53 (s, 4H), 3.25 (td, J = 13.1, 12.4, 5.5 Hz, 4H), 1.74 (s, 1H), 1.59 (p, J = 8.9, 7.9 Hz, 3H), 1.39 (s, 12H), 1.16 (d, J = 11.3 Hz, 1H). [M + H].sup.+ = 492.3 36 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.62 (s, 1H), 8.13 (d, J = 7.8 Hz, 1H), 7.88 (d, J = 8.5 Hz, 1H), 7.81 (s, 1H), 7.76 (s, 1H), 7.55 (s, 1H), 7.31 (q, J = 7.9 Hz, 2H), 7.20 (d, J = 7.2 Hz, 1H), 7.12 (d, J = 8.4 Hz, 1H), 4.08 (dq, J = 13.4, 6.8 Hz, 1H), 3.59-3.50 (m, 2H), 3.48-3.39 (m, 2H), 2.95 (s, 3H), 1.96 (ddd, J = 13.6, 8.3, 5.5 Hz, 1H), 1.15 (d, J = 6.6 Hz, 6H), 1.01-0.91 (m, 2H), 0.60 (d, J = 5.0 Hz, 2H). [M + H].sup.+ = 420.1 37 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.56 (s, 1H), 8.21-8.06 (m, 3H), 7.87 (dd, J = 8.2, 1.9 Hz, 1H), 7.11 (d, J = 8.2 Hz, 1H), 7.06-6.96 (m, 4H), 6.46 (dt, J = 7.6, 1.6 Hz, 1H), 3.54 (s, 4H), 2.56- 2.52 (m, 1H), 1.39 (s, 9H), 1.04 (d, J = 6.8 Hz, 6H). [M + H].sup.+ = 422.3 38 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.20 (d, J = 1.9 Hz, 1H), 8.13 (s, 2H), 7.88 (dd, J = 8.1, 1.9 Hz, 1H), 7.26-7.10 (m, 3H), 6.89-6.45 (m, 3H), 4.77-3.79 (m, 1H), 3.53 (s, 4H), 2.73 (s, 3H), 1.39 (s, 9H), 1.10-1.01 (m, 6H). [M + H].sup.+ = 436.1 39 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.28-8.18 (m, 2H), 8.13 (s, 2H), 7.88 (dd, J = 8.2, 1.8 Hz, 1H), 7.24-7.15 (m, 3H), 7.11 (dd, J = 7.9, 4.8 Hz, 2H), 6.85-6.78 (m, 1H), 3.82 (dd, J = 11.2, 3.1 Hz, 2H), 3.54 (s, 4H), 3.30-3.20 (m, 4H), 1.64-1.41 (m, 5H), 1.39 (s, 9H), 1.15 (qd, J = 12.4, 4.3 Hz, 2H). [M + H].sup.+ = 492.1 40 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.39 (t, J = 5.6 Hz, 1H), 8.12 (s, 2H), 8.08-8.02 (m, 2H), 7.91- 7.83 (m, 2H), 7.62 (s, 1H), 6.71 (d, J = 5.1 Hz, 1H), 3.52 (s, 4H), 3.26 (q, J = 6.7 Hz, 2H), 2.27 (s, 3H), 1.95 (ddd, J = 13.8, 8.4, 5.5 Hz, 1H), 1.65 (dp, J = 13.3, 6.6 Hz, 1H), 1.42 (q, J = 7.0 Hz, 2H), 1.01-0.95 (m, 2H), 0.92 (d, J = 6.6 Hz, 6H), 0.64-0.56 (m, 2H). [M + H].sup.+ = 449.2 41 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 11.24 (s, 1H), 9.35 (s, 1H), 7.81 (d, J = 9.6 Hz, 1H), 7.75 (s, 2H), 7.16 (t, J = 8.2 Hz, 2H), 6.78-6.64 (m, 2H), 6.50 (d, J = 8.5 Hz, 1H), 4.06 (s, 2H), 3.91 (t, J = 6.5 Hz, 2H), 1.93 (d, J = 13.8 Hz, 1H), 1.67 (d, J = 14.8 Hz, 7H), 1.30-1.16 (m, 6H), 0.98 (d, J = 8.6 Hz, 2H), 0.86 (s, 2H), 0.61 (s, 2H). [M + H].sup.+ = 475.1 42 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.33 (d, J = 1.9 Hz, 1H), 8.15 (s, 2H), 8.06 (dd, J = 8.7, 1.7 Hz, 1H), 7.40 (s, 1H), 7.36-7.24 (m, 2H), 6.98 (dd, J = 7.0, 1.8 Hz, 1H), 6.94 (d, J = 8.7 Hz, 1H), 3.74- 3.49 (m, 10H), 3.29-3.17 (m, 2H), 1.70 (ddd, J = 14.2, 8.4, 5.7 Hz, 1H), 0.75 (ddd, J = 17.3, 8.8, 4.7 Hz, 2H), 0.61 (td, J = 9.2, 8.8, 5.3 Hz, 1H), 0.31-0.22 (m, 1H). [M + H].sup.+ = 502.2 43 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.67 (s, 1H), 8.13 (d, J = 7.8 Hz, 1H), 7.87 (d, J = 8.4 Hz, 1H), 7.82 (s, 2H), 7.55 (s, 1H), 7.31 (q, J = 7.7 Hz, 2H), 7.20 (d, J = 7.2 Hz, 1H), 7.12 (d, J = 8.4 Hz, 1H), 4.08 (dq, J = 13.4, 6.7 Hz, 1H), 3.55-3.46 (m, 2H), 3.44-3.35 (m, 2H), 2.71 (ddt, J = 10.9, 7.1, 3.5 Hz, 1H), 1.97 (ddd, J = 13.7, 8.4, 5.0 Hz, 1H), 1.15 (d, J = 6.6 Hz, 6H), 1.01-0.91 (m, 2H), 0.75 (d, J = 6.7 Hz, 4H), 0.61 (q, J = 5.7 Hz, 2H). [M + H].sup.+ = 446.1 44 .sup.1H NMR (500 MHz, d.sub.6-DMSO) δ 8.92 (s, 1H), 8.37 (t, J = 5.6 Hz, 1H), 8.08 (s, 2H), 8.03 (d, J = 1.8 Hz, 1H), 7.87 (dd, J = 8.4, 1.8 Hz, 1H), 7.51 (s, 1H), 7.37-7.30 (m, 2H), 7.25-7.20 (m, 2H), 5.91 (s, 1H), 3.51 (s, 4H), 3.29-3.23 (m, 2H), 1.61 (dt, J = 13.6, 6.8 Hz, 1H), 1.57 (s, 6H), 1.41 (q, J = 7.0 Hz, 2H), 0.90 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 452.3 45 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.33 (s, 1H), 8.13 (s, 2H), 8.05 (s, 1H), 7.92 (d, J = 8.2 Hz, 1H), 7.42 (d, J = 7.4 Hz, 1H), 7.29 (dd, J = 8.1, 3.9 Hz, 2H), 6.85 (d, J = 7.7 Hz, 1H), 6.04 (s, 1H), 3.67 (s, 4H), 3.59-3.50 (m, 6H), 3.21 (d, J = 5.1 Hz, 2H), 1.56 (d, J = 10.1 Hz, 6H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 166.3, 140.3, 137.3, 135.5, 128.8, 128.6, 127.1, 118.9, 118.2, 117.9, 116.9, 72.8, 66.6, 66.4, 47.1, 41.9, 41.7, 29.9 [M + H].sup.+ = 486.2 46 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.70 (s, 1H), 7.81 (d, J = 8.4 Hz, 1H), 7.73 (d, J = 10.6 Hz, 2H), 7.16 (dd, J = 14.6, 8.2 Hz, 2H), 6.71 (d, J = 8.1 Hz, 1H), 6.67 (s, 1H), 6.48 (d, J = 8.4 Hz, 1H), 3.91 (t, J = 6.5 Hz, 2H), 3.87-3.78 (m, 2H), 3.59 (t, J = 8.5 Hz, 2H), 2.72 (s, 3H), 1.96 (t, J = 5.3 Hz, 1H), 1.68 (t, J = 14.8 Hz, 7H), 1.33-1.09 (m, 6H), 0.98 (q, J = 5.1, 4.5 Hz, 2H), 0.88 (q, J = 10.2, 9.2 Hz, 2H), 0.58 (q, J = 5.1 Hz, 2H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 176.3, 170.0, 160.0, 158.4, 146.5, 144.8, 131.1, 130.2, 129.6, 128.1, 127.8, 115.8, 111.5, 107.6, 105.5, 68.1, 42.5, 37.2, 33.7, 33.3, 26.6, 26.5, 26.3, 25.9, 11.4, 7.7 [M + H].sup.+ = 503.1 47 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.59 (s, 1H), 8.11 (s, 2H), 8.07 (s, 1H), 7.84 (dd, J = 8.3, 2.0 Hz, 1H), 7.71 (d, J = 1.9 Hz, 1H), 7.29 (t, J = 1.7 Hz, 1H), 7.18 (d, J = 8.4 Hz, 1H), 7.03-6.97 (m, 1H), 6.83 (dt, J = 11.2, 2.2 Hz, 1H), 3.52 (s, 4H), 2.00-1.88 (m, 1H), 1.34 (s, 3H), 0.99-0.89 (m, 2H), 0.75-0.68 (m, 2H), 0.63-0.54 (m, 4H). [M + H].sup.+ = 436.2 48 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.29 (t, J = 5.7 Hz, 1H), 8.21 (d, J = 1.8 Hz, 1H), 8.13 (s, 2H), 7.88 (dd, J = 8.2, 1.8 Hz, 1H), 7.23-7.15 (m, 3H), 7.14-7.07 (m, 2H), 6.81 (dd, J = 1.6, 1.8 Hz, 1H), 3.81 (t, J = 7.6 Hz, 1H), 3.71 (td, J = 8.2, 4.7 Hz, 1H), 3.61 (q, J = 7.7 Hz, 1H), 3.53 (s, 4H), 3.27-3.17 (m, 3H), 2.13 (dq, J = 14.7, 7.4 Hz, 1H), 2.06-1.96 (m, 1H), 1.56 (q, J = 6.9 Hz, 2H), 1.39 (s, 10H). [M + H].sup.+ = 478.3 49 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 11.33 (s, 1H), 9.43 (s, 1H), 8.22 (s, 1H), 8.05 (d, J = 8.0 Hz, 1H), 7.90 (d, J = 8.2 Hz, 1H), 7.31 (s, 1H), 7.20 (s, 3H), 7.15 (d, J = 8.2 Hz, 1H), 6.89 (s, 1H), 4.17- 3.99 (m, 3H), 1.42 (s, 9H), 1.14 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 436.1 50 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.43 (d, J = 7.8 Hz, 1H), 8.12 (s, 2H), 7.85 (dd, J = 8.3, 1.9 Hz, 1H), 7.80 (d, J = 1.8 Hz, 1H), 7.34 (s, 1H), 7.28-7.21 (m, 1H), 7.10 (dd, J = 8.2, 1.5 Hz, 1H), 7.05 (d, J = 8.4 Hz, 1H), 6.90 (dd, J = 7.4, 1.5 Hz, 1H), 3.97 (d, J = 7.6 Hz, 1H), 3.90-3.81 (m, 2H), 3.52 (s, 4H), 3.44-3.35 (m, 2H), 1.93-1.83 (m, 1H), 1.79 (d, J = 12.5 Hz, 2H), 1.58-1.45 (m, 2H), 1.00-0.90 (m, 2H), 0.64-0.57 (m, 2H). [M + H].sup.+ = 482.0 51 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 8.03 (d, J = 1.8 Hz, 1H), 7.80 (dd, J = 8.4, 1.9 Hz, 1H), 7.51 (s, 1H), 7.15 (d, J = 8.4 Hz, 1H), 7.08 (t, J = 8.1 Hz, 1H), 6.55 (d, J = 8.1 Hz, 1H), 6.49 (d, J = 2.1 Hz, 1H), 6.37 (dd, J = 8.1, 2.1 Hz, 1H), 3.93-3.72 (m, 5H), 3.69-3.58 (m, 2H), 3.52 (s, 4H), 3.50-3.34 (m, 2H), 3.28 (t, J = 8.6 Hz, 1H), 2.01 (s, 2H), 1.79 (d, J = 8.2 Hz, 2H), 1.64 (dd, J = 7.1, 4.7 Hz, 2H), 1.48 (s, 2H). [M + H].sup.+ = 465.1 52 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.19 (d, J = 1.9 Hz, 1H), 8.12 (s, 2H), 7.87 (dd, J = 8.2, 1.9 Hz, 1H), 7.12 (d, J = 8.2 Hz, 1H), 7.06-6.96 (m, 2H), 6.33 (d, J = 8.2 Hz, 1H), 6.29-6.22 (m, 2H), 3.85-3.71 (m, 5H), 3.67-3.57 (m, 2H), 3.53 (s, 4H), 3.49-3.43 (m, 1H), 3.39-3.36 (m, 1H), 1.38 (s, 9H). [M + H].sup.+ = 453.1 53 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.11-9.01 (m, 1 H), 8.13-8.05 (m, 2 H), 7.87-7.77 (m, 2 H), 7.74-7.70 (m, 1 H), 7.56-7.49 (m, 1 H), 7.36-7.27 (m, 2 H), 7.26-7.19 (m, 1 H), 7.15-7.06 (m, 1 H), 3.51 (s, 4 H), 1.99-1.87 (m, 1 H), 1.34-1.25 (m, 2 H), 1.16-1.08 (m, 2 H), 1.00- 0.89 (m, 2 H), 0.62-0.52 (m, 2 H). [M + H].sup.+ = 472.1 54 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.66 (s, 1H), 8.33 (d, J = 8.0 Hz, 1H), 8.19 (s, 1H), 8.12 (s, 2H), 7.87 (d, J = 6.3 Hz, 1H), 7.66 (d, J = 6.6 Hz, 1H), 7.23 (d, J = 8.3 Hz, 2H), 6.92 (d, J = 8.3 Hz, 1H), 6.75 (t, J = 7.3 Hz, 1H), 4.18-4.05 (m, 1H), 3.54 (s, 4H), 1.41 (s, 9H), 1.18 (d, J = 6.6 Hz, 6H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 168.6, 146.0, 142.4, 141.9, 132.2, 129.2, 128.2, 127.7, 124.1, 118.6, 117.5, 114.7, 41.8, 41.2, 34.9, 30.4, 22.7 [M + H].sup.+ = 422.0 55 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.46 (s, 1H), 8.22 (s, 1H), 8.15 (s, 2H), 8.08 (d, J = 5.2 Hz, 1H), 8.03 (s, 1H), 7.90 (d, J = 8.1 Hz, 1H), 7.17 (d, J = 7.9 Hz, 1H), 6.95 (d, J = 5.8 Hz, 1H), 6.90 (s, 1H), 3.54 (s, 4H), 3.23 (d, J = 8.1 Hz, 2H), 1.58 (d, J = 6.7 Hz, 1H), 1.37 (s, 11H), 0.89 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 451.1 56 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.64 (s, 1H), 8.57 (s, 1H), 8.17 (s, 3H), 7.84 (s, 1H), 7.67 (d, J = 7.8 Hz, 1H), 7.26 (s, 2H), 6.78 (s, 2H), 3.56 (s, 4H), 3.12-3.07 (m, 2H), 1.90-1.81 (m, 1H), 1.41 (s, 9H), 0.91 (d, J = 6.7 Hz, 6H). [M + H].sup.+ = 436.0 57 [M + H].sup.+ = 435.3 58 .sup.1H NMR (500 MHz, d.sub.6-DMSO) δ 8.32 (t, J = 5.6 Hz, 1H), 8.08 (s, 2H), 7.78 (s, 2H), 7.72 (d, J = 1.9 Hz, 1H), 7.53 (s, 1H), 7.30 (d, J = 5.0 Hz, 2H), 7.22-7.15 (m, 1H), 7.11 (d, J = 8.4 Hz, 1H), 3.82 (dd, J = 11.4, 2.8 Hz, 2H), 3.51 (s, 4H), 3.30-3.21 (m, 4H), 1.94 (ddd, J = 13.7, 8.4, 5.4 Hz, 1H), 1.60 (d, J = 13.0 Hz, 2H), 1.45 (q, J = 6.9 Hz, 3H), 1.15 (qd, J = 12.0, 4.4 Hz, 2H), 0.98- 0.90 (m, 2H), 0.61-0.54 (m, 2H). [M + H].sup.+ = 476.1 59 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (d, J = 11.1 Hz, 3H), 8.05 (s, 1H), 7.84 (d, J = 9.8 Hz, 1H), 7.81 (s, 1H), 7.43 (s, 1H), 7.28 (s, 2H), 7.14 (d, J = 8.4 Hz, 1H), 7.07 (s, 1H), 4.11-3.99 (m, 2H), 3.96 (d, J = 4.6 Hz, 1H), 3.80-3.65 (m, 2H), 3.59-3.54 (m, 1H), 3.53 (s, 4H), 2.33 (s, 1H), 1.89 (d, J = 7.4 Hz, 1H), 1.15 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 436.1 60 [M + H].sup.+ = 457.3 61 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.45 (s, 1H), 8.16 (d, J = 7.8 Hz, 1H), 7.92 (s, 2H), 7.81 (s, 1H), 7.62 (s, 1H), 7.39 (d, J = 7.8 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 7.27 (d, J = 8.1 Hz, 1H), 7.15 (d, J = 8.5 Hz, 1H), 4.12 (s, 2H), 4.11-4.04 (m, 1H), 3.06 (s, 3H), 1.98 (s, 1H), 1.16 (d, J = 6.6 Hz, 6H), 1.02-0.94 (m, 2H), 0.62 (q, J = 5.6 Hz, 2H). [M + H].sup.+ = 434.0 62 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.91 (s, 1H), 8.52 (s, 1H), 8.10 (s, 2H), 7.83 (d, J = 10.4 Hz, 2H), 7.63 (d, J = 7.5 Hz, 1H), 7.41-7.32 (m, 2H), 7.29 (d, J = 8.3 Hz, 1H), 6.93-6.86 (m, 1H), 3.52 (s, 4H), 3.28 (d, J = 6.7 Hz, 2H), 1.81 (s, 1H), 1.67-1.59 (m, 1H), 1.43 (q, J = 7.0 Hz, 2H), 1.01 (d, J = 8.3 Hz, 2H), 0.90 (d, J = 6.6 Hz, 6H), 0.57 (d, J = 3.7 Hz, 2H). [M + H].sup.+ = 434.0 63 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.66 (s, 1H), 8.13 (s, 2H), 8.03 (s, 1H), 7.84 (d, J = 9.8 Hz, 1H), 7.66 (s, 1H), 7.33 (s, 1H), 7.15 (d, J = 8.4 Hz, 1H), 7.10 (t, J = 8.1 Hz, 1H), 7.03 (d, J = 8.0 Hz, 1H), 6.62 (d, J = 7.2 Hz, 1H), 4.02 (s, 1H), 3.94 (dd, J = 8.4, 4.5 Hz, 1H), 3.76 (q, J = 7.8 Hz, 1H), 3.72-3.65 (m, 1H), 3.58-3.54 (m, 1H), 3.52 (s, 4H), 2.59-2.52 (m, 1H), 2.31 (dd, J = 11.8, 4.5 Hz, 1H), 1.86 (dd, J = 12.2, 7.9 Hz, 1H), 1.07 (d, J = 6.8 Hz, 6H). [M + H].sup.+ = 436.0 64 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 9.22 (s, 1H), 8.12 (s, 2H), 7.77-7.71 (m, 2H), 7.27-7.15 (m, 3H), 7.05 (d, J = 7.0 Hz, 1H), 6.56 (d, J = 9.0 Hz, 1H), 3.52 (s, 4H), 2.17 (s, 3H), 1.94-1.82 (m, 1H), 1.56 (dd, J = 8.2, 5.4 Hz, 2H), 1.28 (dd, J = 8.2, 5.4 Hz, 2H), 1.01-0.91 (q, J = 5.7 Hz, 2H), 0.59 (q, J = 5.7 Hz, 2H). [M + H].sup.+ = 443.3 65 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.40 (d, J = 7.8 Hz, 1H), 8.31 (s, 1H), 8.13 (s, 2H), 7.86 (dd, J = 8.3, 2.0 Hz, 1H), 7.77-7.66 (m, 2H), 7.58 (s, 1H), 7.32 (t, J = 1.9 Hz, 1H), 7.20 (d, J = 8.4 Hz, 1H), 4.10 (dq, J = 13.5, 6.7 Hz, 1H), 3.54 (s, 4H), 1.93 (m, 1H), 1.18 (d, J = 6.6 Hz, 6H), 1.00- 0.88 (m, 2H), 0.66-0.58 (m, 2H). [M + H].sup.+ = 474.2 66 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.13-8.03 (m, 3H), 7.82-7.68 (m, 3H), 7.26-7.21 (m, 1H), 7.20-7.11 (m, 2H), 7.05 (d, J = 8.4 Hz, 1H), 4.09-3.99 (m, 1H), 3.51 (s, 4H), 1.96-1.87 (m, 1H), 1.14 (d, J = 6.6 Hz, 6H), 0.99-0.91 (m, 2H), 0.62-0.54 (m, 2H). [M + H].sup.+ = 424.1 67 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.79 (s, 1H), 8.08 (s, 2H), 8.02 (d, J = 1.9 Hz, 1H), 7.87 (dd, J = 8.5, 1.8 Hz, 1H), 7.24 (d, J = 8.4 Hz, 1H), 7.15 (t, J = 8.1 Hz, 1H), 6.63 (d, J = 8.1 Hz, 1H), 6.59 (d, J = 2.2 Hz, 1H), 6.47 (dd, J = 8.2, 2.0 Hz, 1H), 5.86 (s, 1H), 3.92 (d, J = 6.5 Hz, 2H), 3.83 (dd, J = 10.8, 3.0 Hz, 2H), 3.52 (s, 4H), 3.30-3.22 (m, 2H), 1.71 (dt, J = 14.5, 6.6 Hz, 2H), 1.60 (s, 1H), 1.56 (s, 7H), 1.50 (s, 1H), 1.37-1.31 (m, 2H), 1.20-1.07 (m, 2H). [M + H].sup.+ = 481.1 68 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.01 (s, 1H), 7.93 (d, J = 9.5 Hz, 1H), 7.67 (s, 1H), 7.53 (d, J = 8.4 Hz, 1H), 7.23 (d, J = 8.0 Hz, 1H), 7.18 (d, J = 7.5 Hz, 1H), 6.67 (d, J = 8.5 Hz, 1H), 6.31 (s, 1H), 5.00 (d, J = 6.0 Hz, 2H), 4.61 (d, J = 6.1 Hz, 2H), 3.72 (s, 4H), 2.14 (s, 3H), 1.82-1.73 (m, 1H), 1.71 (s, 3H), 1.04-0.95 (m, 2H), 0.81-0.74 (m, 2H). [M + H].sup.+ = 448.3 69 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.79 (s, 1H), 8.08 (s, 2H), 8.02 (d, J = 1.9 Hz, 1H), 7.87 (dd, J = 8.5, 1.8 Hz, 1H), 7.24 (d, J = 8.4 Hz, 1H), 7.15 (t, J = 8.1 Hz, 1H), 6.63 (d, J = 8.1 Hz, 1H), 6.59 (d, J = 2.2 Hz, 1H), 6.47 (dd, J = 8.2, 2.0 Hz, 1H), 5.86 (s, 1H), 3.92 (d, J = 6.5 Hz, 2H), 3.83 (dd, J = 10.8, 3.0 Hz, 2H), 3.52 (s, 4H), 3.30-3.22 (m, 2H), 1.71 (dt, J = 14.5, 6.6 Hz, 2H), 1.60 (s, 1H), 1.56 (s, 7H), 1.50 (s, 1H), 1.37-1.31 (m, 2H), 1.20-1.07 (m, 2H). [M + H].sup.+ = 450.0 70 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.89 (s, 1H), 8.35 (d, J = 7.7 Hz, 1H), 8.10 (s, 2H), 7.84 (d, J = 8.7 Hz, 2H), 7.64 (d, J = 7.4 Hz, 1H), 7.42-7.33 (m, 2H), 7.29 (d, J = 8.2 Hz, 1H), 6.93-6.86 (m, 1H), 4.14-4.04 (m, 1H), 3.52 (s, 4H), 1.84-1.76 (m, 1H), 1.17 (d, J = 6.6 Hz, 6H), 1.02 (dd, J = 8.3, 1.9 Hz, 2H), 0.57 (d, J = 3.8 Hz, 2H). [M + H].sup.+ = 406.0 71 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.17 (d, J = 2.0 Hz, 1H), 8.03 (d, J = 7.8 Hz, 1H), 7.84 (dd, J = 8.1, 1.9 Hz, 1H), 7.25-7.06 (m, 5H), 6.84-6.74 (m, 1H), 4.14-3.99 (m, 1H), 3.58 (s, 4H), 2.81 (s, 6H), 1.40 (s, 9H), 1.16 (d, J = 6.6 Hz, 6H). [M + H].sup.+ = 450.3 72 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.76 (s, 1H), 8.11 (s, 2H), 8.07 (s, 1H), 7.87 (s, 1H), 7.84 (d, J = 8.9 Hz, 1H), 7.54 (s, 1H), 7.21 (d, J = 4.4 Hz, 3H), 6.84 (s, 1H), 3.53 (s, 4H), 2.62-2.53 (m, 1H), 1.08 (d, J = 6.8 Hz, 6H). [M + H].sup.+ = 400.0 73 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.18-8.06 (m, 3H), 7.84 (dd, J = 8.3, 2.0 Hz, 1H), 7.70 (d, J = 1.9 Hz, 1H), 7.20 (d, J = 8.3 Hz, 1H), 6.83-6.72 (m, 2H), 6.65-6.53 (m, 1H), 3.70-3.33 (m, 12H), 2.01-1.86 (m, 1H), 1.02-0.91 (m, 2H), 0.66-0.55 (m, 2H). [M + H].sup.+ = 452.2 74 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.48 (t, J = 5.7 Hz, 1H), 8.22 (d, J = 1.9 Hz, 1H), 8.15 (s, 2H), 8.08 (d, J = 5.2 Hz, 1H), 8.04 (s, 1H), 7.90 (dd, J = 8.1, 1.8 Hz, 1H), 7.17 (d, J = 8.1 Hz, 1H), 6.95 (d, J = 5.3 Hz, 1H), 6.89 (s, 1H), 3.82 (dd, J = 11.1, 3.0 Hz, 2H), 3.54 (s, 4H), 3.29-3.20 (m, 4H), 1.59 (d, J = 13.2 Hz, 2H), 1.54-1.40 (m, 3H), 1.37 (s, 8H), 1.15 (qd, J = 12.4, 4.3 Hz, 2H). [M + H].sup.+ = 493.1 75 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.10 (s, 2H), 7.86 (s, 1H), 7.79 (d, J = 8.4 Hz, 1H), 7.70 (s, 1H), 7.31 (t, J = 7.9 Hz, 1H), 7.16 (d, J = 8.4 Hz, 1H), 7.05 (d, J = 8.5 Hz, 1H), 6.90 (s, 1H), 6.76 (d, J = 8.1 Hz, 1H), 3.52 (s, 4H), 3.12 (s, 3H), 2.58 (s, 1H), 2.02-1.90 (m, 1H), 0.94 (d, J = 6.6 Hz, 8H), 0.58 (q, J = 5.0, 4.5 Hz, 2H). [M + H].sup.+ = 420.0 76 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.08 (s, 2H), 7.89 (d, J = 7.5 Hz, 1H), 7.76 (dd, J = 1.9, 8.4 Hz, 1H), 7.70 (d, J = 1.8 Hz, 1H), 7.59 (s, 1H), 7.21-7.13 (m, 1H), 7.09 (d, J = 8.5 Hz, 1H), 7.04- 6.99 (m, 1H), 6.97-6.90 (m, 1H), 6.76 (d, J = 7.4 Hz, 1H), 3.86-3.74 (m, 1H), 3.50 (s, 4H), 3.28 (s, 2H), 2.00-1.87 (m, 1H), 1.04 (d, J = 6.6 Hz, 6H), 0.97-0.90 (m, 2H), 0.60-0.51 (m, 2H). [M + H].sup.+ = 420.2 77 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.19 (d, J = 7.7 Hz, 1H), 8.15-8.07 (m, 3H), 7.83 (dd, J = 2.0, 8.4 Hz, 1H), 7.71 (d, J = 2.0 Hz, 1H), 7.33 (t, J = 1.7 Hz, 1H), 7.19 (d, J = 8.4 Hz, 1H), 7.09-7.01 (m, 1H), 6.84 (td, J = 2.2, 11.3 Hz, 1H), 4.12-3.96 (m, 1H), 3.52 (s, 4H), 2.00-1.89 (m, 1H), 1.15 (d, J = 6.6 Hz, 6H), 1.00-0.89 (m, 2H), 0.62-0.56 (m, 2H). [M + H].sup.+ = 424.1 78 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.11 (s, 1H), 8.09 (s, 2H), 8.05 (d, J = 1.9 Hz, 1H), 7.87 (dd, J = 8.5, 1.9 Hz, 1H), 7.30 (dd, J = 8.2, 1.1 Hz, 1H), 7.25 (d, J = 8.5 Hz, 1H), 7.17 (t, J = 7.8 Hz, 1H), 6.67 (dd, J = 7.5, 1.1 Hz, 1H), 5.82 (s, 1H), 3.76-3.48 (m, 10H), 3.24 (t, J = 5.5 Hz, 2H), 1.59 (d, J = 9.9 Hz, 7H), 1.00-0.88 (m, 2H), 0.69-0.61 (m, 1H), 0.36-0.29 (m, 1H). [M + H].sup.+ = 492.3 79 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.29 (t, J = 5.7 Hz, 1H), 8.13 (d, J = 2.3 Hz, 3H), 7.92 (dd, J = 10.4, 1.4 Hz, 2H), 7.73 (t, J = 1.7 Hz, 1H), 7.66 (s, 1H), 7.44 (s, 1H), 7.29-7.22 (m, 3H), 7.11- 7.03 (m, 1H), 6.73 (d, J = 1.1 Hz, 1H), 3.82 (dd, J = 10.9, 3.5 Hz, 2H), 3.53 (s, 4H), 3.29-3.20 (m, 4H), 1.60 (d, J = 13.5 Hz, 2H), 1.53 (s, 1H), 1.44 (q, J = 6.8 Hz, 2H), 1.15 (qd, J = 12.4, 4.5 Hz, 2H). [M + H].sup.+ = 502.2 80 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.86 (s, 1H), 8.58 (t, J = 5.8 Hz, 1H), 8.11 (s, 2H), 7.83 (dd, J = 10.8, 2.4 Hz, 2H), 7.68-7.63 (m, 1H), 7.38 (d, J = 6.6 Hz, 2H), 7.30 (d, J = 8.3 Hz, 1H), 6.91 (t, J = 6.3 Hz, 1H), 3.53 (s, 4H), 3.12-3.06 (m, 2H), 1.90-1.83 (m, 1H), 1.83-1.77 (m, 1H), 1.05- 0.98 (m, 2H), 0.90 (d, J = 6.7 Hz, 6H), 0.56 (d, J = 3.8 Hz, 2H). [M + H].sup.+ = 420.0 81 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 11.17 (s, 1H), 8.16 (d, J = 7.8 Hz, 1H), 7.91 (d, J = 8.7 Hz, 2H), 7.77 (s, 1H), 7.62 (s, 1H), 7.43-7.30 (m, 2H), 7.27 (d, J = 7.7 Hz, 1H), 7.14 (d, J = 8.4 Hz, 1H), 4.16-4.01 (m, 3H), 3.09 (s, 3H), 1.97 (ddd, J = 13.7, 8.3, 5.4 Hz, 1H), 1.16 (d, J = 6.6 Hz, 6H), 1.03-0.94 (m, 2H), 0.61 (q, J = 5.3 Hz, 2H). [M + H].sup.+ = 434.3 82 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.09 (s, 2H), 7.78 (dd, J = 8.4, 2.0 Hz, 1H), 7.73 (d, J = 2.0 Hz, 1H), 7.66 (s, 1H), 7.30 (t, J = 7.8 Hz, 1H), 7.23 (s, 1H), 7.11 (d, J = 8.4 Hz, 1H), 7.04 (td, J = 7.6, 1.9 Hz, 2H), 4.76 (d, J = 5.9 Hz, 2H), 4.66 (d, J = 5.9 Hz, 2H), 3.52 (s, 4H), 2.83-2.65 (m, 1H), 2.44 (t, J = 6.2 Hz, 1H), 1.98 (m, 1H), 1.02-0.93 (m, 2H), 0.86 (d, J = 6.3 Hz, 6H), 0.65-0.55 (m, 2H). [M + H].sup.+ = 434.2 83 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.26-8.17 (m, 1H), 8.08 (s, 2H), 7.76 (dd, J = 1.9, 8.5 Hz, 1H), 7.71 (d, J = 1.7 Hz, 1H), 7.62 (s, 1H), 7.19 (t, J = 7.8 Hz, 1H), 7.10 (d, J = 8.4 Hz, 1H), 6.99-6.93 (m, 2H), 6.78-6.72 (m, 1H), 4.20 (d, J = 5.8 Hz, 2H), 3.51 (s, 4H), 2.45-2.37 (m, 1H), 2.00- 1.89 (m, 1H), 1.02 (d, J = 6.8 Hz, 6H), 0.98-0.92 (m, 2H), 0.60-0.52 (m, 2H). [M + H].sup.+ = 420.2 84 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.02 (s, 1H), 8.10 (s, 3H), 7.92 (d, J = 8.5 Hz, 1H), 7.50 (d, J = 12.5 Hz, 2H), 7.38 (d, J = 8.0 Hz, 1H), 7.33 (d, J = 7.0 Hz, 1H), 7.28 (d, J = 8.2 Hz, 1H), 5.93 (s, 1H), 3.78 (d, J = 11.6 Hz, 2H), 3.53 (s, 4H), 3.29-3.19 (m, 4H), 1.56 (s, 9H), 1.46 (d, J = 12.2 Hz, 2H), 1.24 (s, 2H), 1.06 (d, J = 10.5 Hz, 2H). [M + H].sup.+ = 529.0 85 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.79 (s, 1H), 8.08 (s, 2H), 8.02 (d, J = 1.9 Hz, 1H), 7.87 (dd, J = 8.4, 1.9 Hz, 1H), 7.25 (d, J = 8.5 Hz, 1H), 7.15 (t, J = 8.1 Hz, 1H), 6.67-6.58 (m, 2H), 6.48 (dd, J = 8.1, 2.1 Hz, 1H), 5.85 (s, 1H), 3.98 (t, J = 6.3 Hz, 2H), 3.83 (dd, J = 11.1, 3.0 Hz, 2H), 3.52 (s, 4H), 3.30-3.23 (m, 2H), 1.69 (s, 1H), 1.67-1.62 (m, 3H), 1.60 (s, 1H), 1.56 (s, 6H), 1.26-1.16 (m, 2H). [M + H].sup.+ = 467.1 86 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.81 (s, 1H), 8.29 (s, 1H), 8.13 (s, 2H), 7.86 (dd, J = 8.3, 2.0 Hz, 1H), 7.73 (d, J = 2.0 Hz, 1H), 7.68 (t, J = 1.8 Hz, 1H), 7.54 (s, 1H), 7.31 (t, J = 2.0 Hz, 1H), 7.19 (d, J = 8.3 Hz, 1H), 3.54 (s, 4H), 1.99-1.86 (m, 1H), 1.37 (s, 3H), 0.99-0.88 (m, 2H), 0.74 (q, J = 4.6, 4.1 Hz, 2H), 0.62 (m, 4H). [M + H].sup.+ = 486.2 87 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (t, J = 5.5 Hz, 3H), 7.82 (d, J = 7.8 Hz, 1H), 7.68 (s, 1H), 7.65 (dd, J = 7.6, 1.7 Hz, 1H), 7.43 (t, J = 7.1 Hz, 1H), 7.21 (t, J = 7.3 Hz, 1H), 6.84 (d, J = 7.1 Hz, 1H), 6.81 (d, J = 8.5 Hz, 1H), 3.55 (br s, 4H), 3.22 (q, J = 6.7 Hz, 2H), 2.15 (br s, 1H), 1.52 (dp, J = 13.3, 6.7 Hz, 1H), 1.31 (q, J = 7.0 Hz, 2H), 0.97-0.86 (m, 2H), 0.82 (d, J = 6.6 Hz, 6H), 0.72- 0.61 (m, 2H). [M + H].sup.+ = 435.2 88 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.81 (s, 1H), 8.10 (s, 2H), 8.02 (d, J = 1.9 Hz, 1H), 7.87 (dd, J = 8.5, 1.9 Hz, 1H), 7.25 (d, J = 8.5 Hz, 1H), 7.16 (t, J = 8.1 Hz, 1H), 6.65 (dd, J = 7.9, 1.6 Hz, 1H), 6.61 (s, 1H), 6.48 (dd, J = 8.1, 2.0 Hz, 1H), 5.86 (s, 1H), 4.00 (t, J = 6.4 Hz, 2H), 3.72 (td, J = 11.7, 2.5 Hz, 2H), 3.68-3.61 (m, 2H), 3.60-3.55 (m, 1H), 3.52 (s, 4H), 3.45 (td, J = 11.0, 2.6 Hz, 1H), 3.22 (dd, J = 11.3, 9.9 Hz, 1H), 1.75 (pt, J = 13.9, 6.4 Hz, 2H), 1.56 (s, 6H). [M + H].sup.+ = 469.1 89 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.00 (s, 1H), 7.93 (dd, J = 8.6, 1.8 Hz, 1H), 7.16 (d, J = 5.3 Hz, 2H), 7.13-7.07 (m, 1H), 6.86 (d, J = 8.5 Hz, 1H), 6.29 (s, 1H), 4.31-4.18 (m, 4H), 3.71 (s, 4H), 2.22 (s, 3H), 1.81-1.72 (m, 1H), 1.38 (td, J = 7.1, 0.9 Hz, 7H), 1.04-0.94 (m, 2H), 0.81-0.74 (m, 2H). [M + H].sup.+ = 487.3 90 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.96 (d, J = 8.4 Hz, 3H), 7.78 (d, J = 7.7 Hz, 1H), 7.43 (t, J = 7.9 Hz, 1H), 7.33-7.26 (m, 2H), 6.50 (s, 1H), 5.55 (t, J = 7.2 Hz, 1H), 5.23 (d, J = 7.2 Hz, 2H), 3.65 (s, 4H), 1.86 (s, 3H), 1.81 (s, 3H), 1.81-1.74 (m, 1H), 1.00 (q, J = 5.5 Hz, 2H), 0.77 (q, J = 5.5 Hz, 2H). [M + H].sup.+ = 457.3 91 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (s, 2H), 8.05 (d, J = 7.8 Hz, 1H), 7.87 (s, 1H), 7.62 (dd, J = 11.4, 1.8 Hz, 1H), 7.49 (d, J = 1.8 Hz, 1H), 7.22-7.12 (m, 3H), 6.73 (d, J = 7.1 Hz, 1H), 4.11- 4.00 (m, 1H), 3.54 (s, 4H), 2.03-1.93 (m, 1H), 1.14 (d, J = 6.6 Hz, 6H), 0.95-0.88 (m, 2H), 0.65- 0.58 (m, 2H). [M + H].sup.+ = 424.2 92 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.06 (s, 2H), 7.85 (d, J = 8.0 Hz, 1H), 7.82-7.75 (m, 2H), 7.73 (t, J = 1.7 Hz, 1H), 7.67 (dd, J = 1.6, 0.8 Hz, 1H), 7.42-7.30 (m, 2H), 7.03 (d, J = 8.3 Hz, 1H), 6.98 (dd, J = 7.3, 1.4 Hz, 1H), 6.75 (s, 1H), 6.52 (dd, J = 1.8, 0.8 Hz, 1H), 3.91-3.78 (m, 1H), 3.50 (s, 4H), 1.67-1.58 (m, 1H), 0.94 (d, J = 6.6 Hz, 6H), 0.80-0.70 (m, 2H), 0.42-0.32 (m, 2H). [M + H].sup.+ = 472.2 93 .sup.1H NMR (400 MHz, d.sub.6-DMSO) 8 9.36 (s, 1H), 8.18 (d, J = 2.1 Hz, 1H), 8.13 (s, 2H), 7.88 (dd, J = 8.4, 2.0 Hz, 1H), 7.80 (s, 1H), 7.14-7.04 (m, 2H), 6.77 (d, J = 9.6 Hz, 1H), 6.72 (d, J = 8.4 Hz, 1H), 3.53 (s, 4H), 2.32 (t, J = 7.5 Hz, 2H), 1.50 (dd, J = 12.9, 6.5 Hz, 1H), 1.47-1.42 (m, 2H), 1.41 (s, 9H), 0.84 (d, J = 6.4 Hz, 6H). [M + H].sup.+ = 451.1 94 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.59 (d, J = 7.8 Hz, 1H), 8.11 (s, 2H), 7.85 (dd, J = 8.3, 1.9 Hz, 1H), 7.79 (d, J = 1.8 Hz, 1H), 7.35 (s, 1H), 7.30-7.21 (m, 1H), 7.10 (dd, J = 8.2, 1.5 Hz, 1H), 7.05 (d, J = 8.3 Hz, 1H), 6.92 (dd, J = 7.4, 1.5 Hz, 1H), 4.27-4.04 (m, 1H), 3.52 (s, 4H), 3.30-3.22 (m, 2H), 3.14 (d, J = 14.5 Hz, 2H), 2.16 (s, 2H), 2.03 (d, J = 10.3 Hz, 2H), 1.88 (ddd, J = 13.7, 8.2, 5.4 Hz, 1H), 0.99-0.90 (m, 2H), 0.65-0.56 (m, 2H). [M + H].sup.+ = 529.9 95 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.41 (d, J = 6.5 Hz, 1H), 8.10 (s, 2H), 8.05 (d, J = 1.9 Hz, 1H), 7.80 (dd, J = 8.4, 1.9 Hz, 1H), 7.68 (s, 1H), 7.47-7.42 (m, 1H), 7.31-7.21 (m, 2H), 7.12 (d, J = 8.4 Hz, 1H), 7.10-7.04 (m, 1H), 4.41 (dd, J = 11.7, 7.1 Hz, 1H), 3.89-3.78 (m, 2H), 3.70 (td, J = 8.0, 5.9 Hz, 1H), 3.56 (dd, J = 8.8, 4.5 Hz, 1H), 3.52 (s, 4H), 3.30-3.22 (m, 1H), 2.18-2.08 (m, 1H), 2.02 (s, 2H), 1.96-1.85 (m, 1H), 1.79 (d, J = 8.1 Hz, 2H), 1.63 (dd, J = 7.1, 4.6 Hz, 2H), 1.55- 1.43 (m, 2H). [M + H].sup.+ = 462.2 96 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.20 (d, J = 7.7 Hz, 1H), 8.10 (s, 2H), 8.05 (d, J = 1.9 Hz, 1H), 7.80 (dd, J = 8.3, 1.9 Hz, 1H), 7.69 (s, 1H), 7.44 (s, 1H), 7.26 (d, J = 5.0 Hz, 2H), 7.12 (d, J = 8.4 Hz, 1H), 7.07 (d, J = 2.4 Hz, 1H), 3.97 (dd, J = 11.4, 3.8 Hz, 1H), 3.87 (d, J = 11.7 Hz, 2H), 3.52 (s, 4H), 3.43-3.33 (m, 2H), 3.31-3.22 (m, 1H), 2.02 (s, 2H), 1.83-1.69 (m, 4H), 1.67-1.41 (m, 6H). [M + H].sup.+ = 476.0 97 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.13 (s, 2H), 8.07 (dd, J = 6.0, 1.9 Hz, 1H), 7.95 (dd, J = 8.4, 1.9 Hz, 1H), 7.88 (d, J = 26.3 Hz, 1H), 7.28 (td, J = 7.9, 2.4 Hz, 1H), 7.24-7.14 (m, 2H), 6.85 (dd, J = 7.3, 1.5 Hz, 1H), 4.94-4.83 (m, 1H), 4.09 (td, J = 12.8, 12.1, 5.8 Hz, 1H), 3.82 (q, J = 7.9 Hz, 1H), 3.66 (s, 4H), 3.55 (d, J = 11.9 Hz, 6H), 3.24-3.14 (m, 2H), 2.24 (td, J = 11.9, 7.5 Hz, 1H), 1.97 (tt, J = 14.7, 7.7 Hz, 2H), 1.85-1.69 (m, 1H). [M + H].sup.+ = 497.9 98 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.16 (d, J = 7.7 Hz, 1H), 8.09 (s, 2H), 7.80 (dd, J = 2.0, 8.4 Hz, 1H), 7.73 (d, J = 2.0 Hz, 1H), 7.44 (s, 1H), 7.20-7.14 (m, 1H), 7.12 (t, J = 7.7 Hz, 1H), 7.08- 7.03 (m, 1H), 6.88 (d, J = 8.4 Hz, 1H), 4.05 (qd, J = 6.7, 13.9 Hz, 1H), 3.51 (s, 4H), 1.97-1.88 (m, 1H), 1.15 (d, J = 6.6 Hz, 6H), 0.97-0.91 (m, 2H), 0.61-0.55 (m, 2H). [M + H].sup.+ = 424.1 99 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.63 (s, 1H), 8.61 (s, 1H), 8.19 (s, 2H), 7.91 (d, J = 5.4 Hz, 1H), 7.67 (dd, J = 10.8, 1.7 Hz, 1H), 7.52 (s, 1H), 6.36 (t, J = 5.1 Hz, 1H), 3.55 (s, 4H), 2.05-1.96 (m, 1H), 1.37 (s, 3H), 0.98-0.88 (m, 2H), 0.79-0.71 (m, 2H), 0.66-0.59 (m, 4H). [M + H].sup.+ = 455.1 100 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.37 (s, 1H), 8.13 (s, 2H), 7.91 (s, 1H), 7.83 (dd, J = 8.4, 2.1 Hz, 1H), 7.71 (d, J = 2.0 Hz, 1H), 7.14-7.02 (m, 2H), 6.76 (dd, J = 9.0, 5.9 Hz, 2H), 3.53 (s, 4H), 2.39- 2.31 (m, 2H), 2.15 (ddd, J = 13.9, 8.6, 5.4 Hz, 1H), 1.50 (dt, J = 13.0, 6.5 Hz, 1H), 1.42 (q, J = 7.1, 6.6 Hz, 2H), 0.94-0.87 (m, 2H), 0.84 (d, J = 6.4 Hz, 6H), 0.70-0.62 (m, 2H). [M + H].sup.+ = 435.1 101 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.64 (s, 1H), 8.60 (s, 1H), 8.31 (d, J = 2.0 Hz, 1H), 8.17 (s, 2H), 8.08 (dd, J = 8.5, 2.0 Hz, 1H), 7.29 (d, J = 4.5 Hz, 2H), 7.11 (d, J = 8.6 Hz, 1H), 6.99 (t, J = 4.5 Hz, 1H), 3.54 (s, 4H), 2.86 (s, 3H), 1.39 (s, 3H), 0.73 (s, 2H), 0.62-0.56 (m, 2H). [M + H].sup.+ = 474.0 102 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.63 (s, 1H), 8.58 (d, J = 2.0 Hz, 1H), 8.29 (s, 1H), 8.20 (s, 2H), 8.17 (d, J = 2.1 Hz, 1H), 7.57 (d, J = 6.6 Hz, 1H), 7.38 (t, J = 7.8 Hz, 1H), 7.18 (d, J = 8.7 Hz, 1H), 7.14-7.09 (m, 1H), 3.54 (s, 4H), 3.26 (s, 3H), 1.40 (s, 3H), 0.74 (s, 2H), 0.63-0.57 (m, 2H). [M + H].sup.+ = 489.9 103 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 7.85 (dd, J = 8.4, 1.8 Hz, 1H), 7.79 (d, J = 1.7 Hz, 1H), 7.43 (s, 1H), 7.31 (t, J = 7.9 Hz, 1H), 7.10 (d, J = 6.8 Hz, 1H), 7.06 (dd, J = 5.2, 2.2 Hz, 2H), 4.36 (s, 1H), 3.79 (s, 1H), 3.62 (s, 2H), 3.52 (s, 4H), 3.37 (d, J = 7.6 Hz, 1H), 3.27 (s, 2H), 3.09 (s, 1H), 1.89 (s, 1H), 0.94 (d, J = 8.4 Hz, 2H), 0.61 (s, 2H). [M + H].sup.+ = 515.9 104 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 7.85 (d, J = 8.6 Hz, 1H), 7.79 (s, 1H), 7.44-7.37 (m, 1H), 7.29 (t, J = 7.7 Hz, 1H), 7.12-6.73 (m, 3H), 4.38-3.65 (m, 3H), 3.52 (s, 4H), 3.40 (s, 2H), 3.29 (s, 1H), 3.11-2.99 (m, 1H), 2.34-2.24 (m, 1H), 1.88 (s, 1H), 1.05-0.57 (m, 10H). [M + H].sup.+ = 510.0 105 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 7.87-7.80 (m, 1H), 7.79 (d, J = 1.9 Hz, 1H), 7.48- 7.37 (m, 1H), 7.29 (td, J = 7.8, 3.5 Hz, 1H), 7.13-6.80 (m, 3H), 4.52-3.73 (m, 2H), 3.52 (s, 4H), 3.44 (d, J = 19.8 Hz, 1H), 3.25-2.66 (m, 4H), 1.93-1.81 (m, 1H), 1.81-1.51 (m, 1H), 0.97- 0.56 (m, 10H). [M + H].sup.+ = 510.0 106 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.13 (s, 2H), 8.00 (d, J = 7.9 Hz, 1H), 7.82-7.76 (m, 1H), 7.61 (s, 1H), 7.48 (d, J = 2.0 Hz, 1H), 7.12 (t, J = 7.7 Hz, 1H), 7.08-7.02 (m, 2H), 6.53-6.47 (m, 1H), 4.10-3.98 (m, 1H), 3.52 (s, 4H), 2.14 (s, 3H), 2.00-1.90 (m, 1H), 1.13 (d, J = 6.6 Hz, 6H), 0.85- 0.76 (m, 2H), 0.56-0.48 (m, 2H). [M + H].sup.+ = 420.2 107 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.42 (s, 1H), 8.08 (s, 2H), 7.81-7.73 (m, 2H), 7.72 (d, J = 1.9 Hz, 1H), 7.50 (d, J = 1.7 Hz, 1H), 7.32-7.24 (m, 2H), 7.21-7.14 (m, 1H), 7.10 (d, J = 8.4 Hz, 1H), 3.51 (s, 4H), 1.99-1.89 (m, 1H), 1.79-1.65 (m, 1H), 1.49 (d, J = 7.0 Hz, 2H), 0.99-0.87 (m, 8H), 0.76-0.69 (m, 2H), 0.61-0.53 (m, 4H). [M + H].sup.+ = 460.2 108 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.54 (s, 1H), 8.08 (s, 2H), 7.79 (dd, J = 8.4, 2.0 Hz, 1H), 7.71 (d, J = 1.9 Hz, 1H), 7.62 (s, 1H), 7.53 (s, 1H), 7.18-7.11 (m, 3H), 6.82-6.76 (m, 1H), 4.36 (dd, J = 8.1, 5.5 Hz, 1H), 4.01-3.93 (m, 1H), 3.86-3.77 (m, 1H), 3.51 (s, 4H), 2.17 (dq, J = 12.1, 7.8 Hz, 1H), 2.01-1.91 (m, 2H), 1.89-1.80 (m, 2H), 0.97-0.91 (m, 2H), 0.60-0.53 (m, 2H). [M + H].sup.+ = 434.3 109 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.48 (t, J = 5.9 Hz, 1H), 8.11 (s, 2H), 7.85 (dd, J = 8.3, 1.9 Hz, 1H), 7.80 (d, J = 1.8 Hz, 1H), 7.34 (s, 1H), 7.25 (t, J = 7.8 Hz, 1H), 7.11 (dd, J = 8.2, 1.4 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 6.90 (dd, J = 7.4, 1.4 Hz, 1H), 3.97 (p, J = 6.3 Hz, 1H), 3.84-3.74 (m, 1H), 3.64 (q, J = 7.4 Hz, 1H), 3.52 (s, 4H), 3.37-3.32 (m, 1H), 3.29-3.22 (m, 1H), 2.00-1.76 (m, 4H), 1.70-1.60 (m, 1H), 0.99-0.91 (m, 2H), 0.64-0.57 (m, 2H). [M + H].sup.+ = 482.1 110 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.72 (d, J = 3.5 Hz, 2H), 7.81 (dd, J = 8.4, 2.0 Hz, 1H), 7.78- 7.70 (m, 2H), 7.50 (s, 1H), 7.20-7.12 (m, 3H), 6.80 (dt, J = 7.0, 2.1 Hz, 1H), 3.83 (dd, J = 10.0, 7.2 Hz, 2H), 3.64-3.55 (m, 2H), 2.73 (s, 3H), 2.63-2.53 (m, 1H), 1.98 (ddd, J = 13.7, 8.4, 5.4 Hz, 1H), 1.09 (d, J = 6.8 Hz, 6H), 1.02-0.92 (m, 2H), 0.62-0.53 (m, 2H). [M + H].sup.+ = 448.3 111 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.30 (s, 1H), 8.08 (s, 2H), 7.78 (dd, J = 8.3, 1.9 Hz, 1H), 7.76- 7.69 (m, 2H), 7.48 (d, J = 2.0 Hz, 1H), 7.27 (d, J = 5.3 Hz, 2H), 7.20-7.13 (m, 1H), 7.11 (d, J = 8.4 Hz, 1H), 3.51 (s, 4H), 1.98-1.88 (m, 1H), 0.98-0.85 (m, 11H), 0.85-0.79 (m, 2H), 0.69- 0.62 (m, 2H), 0.61-0.53 (m, 2H). [M + H].sup.+ = 460.2 112 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.31 (d, J = 11.5 Hz, 2H), 8.11 (s, 2H), 7.85 (dd, J = 8.3, 2.0 Hz, 1H), 7.73-7.69 (m, 2H), 7.64 (t, J = 1.4 Hz, 1H), 7.33 (dd, J = 2.4, 1.4 Hz, 1H), 7.19 (d, J = 8.3 Hz, 1H), 4.06 (dq, J = 13.5, 6.8 Hz, 1H), 3.52 (s, 4H), 1.97-1.86 (m, 1H), 1.15 (d, J = 6.6 Hz, 6H), 0.97-0.87 (m, 2H), 0.64-0.54 (m, 2H). [M + H].sup.+ = 431.2 113 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.69 (s, 1H), 8.79 (s, 1H), 7.86 (dd, J = 8.4, 1.9 Hz, 1H), 7.73 (d, J = 1.9 Hz, 1H), 7.65 (s, 1H), 7.46 (s, 1H), 7.19-7.08 (m, 3H), 6.77 (dt, J = 7.5, 1.8 Hz, 1H), 6.28 (s, 1H), 3.86 (td, J = 15.9, 3.7 Hz, 2H), 3.66-3.49 (m, J = 5.1 Hz, 4H), 2.57 (p, J = 6.8 Hz, 1H), 2.02-1.91 (m, 1H), 1.08 (d, J = 6.8 Hz, 6H), 1.00-0.90 (m, 2H), 0.62-0.53 (m, 2H). [M + H].sup.+ = 470.3 114 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.19 (s, 1H), 8.10 (s, 2H), 7.84 (dd, J = 8.4, 1.9 Hz, 1H), 7.78 (d, J = 1.9 Hz, 1H), 7.36 (s, 1H), 7.24 (t, J = 7.8 Hz, 1H), 7.08 (dd, J = 8.2, 1.5 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 6.88 (dd, J = 7.4, 1.5 Hz, 1H), 3.51 (s, 4H), 1.91-1.81 (m, 1H), 1.35-1.28 (m, 2H), 1.14 (s, 2H), 0.97-0.88 (m, 2H), 0.64-0.54 (m, 2H). [M + H].sup.+ = 506.2 115 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.12 (s, 2H), 7.89-7.79 (m, 2H), 7.55 (t, J = 7.9 Hz, 1H), 7.25 (s, 1H), 7.18 (d, J = 8.3 Hz, 1H), 7.01 (d, J = 8.3 Hz, 1H), 6.93 (d, J = 7.4 Hz, 1H), 3.73-3.45 (m, 10H), 3.21 (ddd, J = 13.1, 6.1, 3.2 Hz, 1H), 3.11 (ddd, J = 13.3, 6.5, 3.3 Hz, 1H), 1.84 (ddd, J = 13.7, 8.3, 5.4 Hz, 1H), 0.95-0.87 (m, 2H), 0.61-0.52 (m, 2H). [M + H].sup.+ = 502.4 116 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.49 (d, J = 4.1 Hz, 1H), 8.13 (s, 2H), 7.81 (s, 2H), 7.52 (t, J = 7.9 Hz, 1H), 7.21 (d, J = 8.0 Hz, 2H), 6.94 (t, J = 6.8 Hz, 2H), 3.53 (s, 4H), 2.76 (tq, J = 7.5, 3.8 Hz, 1H), 1.83 (ddd, J = 13.6, 8.5, 5.5 Hz, 1H), 0.97-0.87 (m, 2H), 0.68 (td, J = 7.0, 4.8 Hz, 2H), 0.59-0.53 (m, 2H), 0.49 (dd, J = 3.9, 2.3 Hz, 2H). [M + H].sup.+ = 472.4 117 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.47 (s, 1H), 8.15 (s, 2H), 7.86 (s, 1H), 7.62 (dd, J = 11.3, 1.8 Hz, 1H), 7.49 (d, J = 1.7 Hz, 1H), 7.20-7.08 (m, 3H), 6.73 (d, J = 7.7 Hz, 1H), 3.54 (s, 4H), 2.04- 1.90 (m, 1H), 1.33 (s, 3H), 0.96-0.86 (m, 2H), 0.73-0.66 (m, 2H), 0.66-0.53 (m, 4H). [M + H].sup.+ = 436.2 118 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.13 (s, 2H), 7.88 (dd, J = 8.3, 2.0 Hz, 1H), 7.76 (d, J = 1.9 Hz, 1H), 7.69 (s, 1H), 7.16 (d, J = 8.3 Hz, 1H), 6.72 (dd, J = 7.9, 2.9 Hz, 1H), 6.57 (dd, J = 11.0, 2.9 Hz, 1H), 3.73-3.47 (m, 10H), 3.24-3.17 (m, 2H), 1.94-1.82 (m, 1H), 0.98-0.86 (m, 2H), 0.65- 0.54 (m, 2H). [M + H].sup.+ = 486.2 119 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (s, 2H), 7.94 (s, 1H), 7.62 (dd, J = 11.4, 1.5 Hz, 1H), 7.47 (s, 1H), 7.20 (t, J = 7.9 Hz, 1H), 6.82-6.65 (m, 2H), 6.59 (s, 1H), 3.80-3.34 (m, 12H), 2.05- 1.92 (m, 1H), 0.98-0.89 (m, 2H), 0.65-0.57 (m, 2H). [M + H].sup.+ = 452.2 120 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.11 (s, 2H), 7.85 (dt, J = 8.3, 1.8 Hz, 1H), 7.79 (d, J = 1.9 Hz, 1H), 7.40 (d, J = 4.4 Hz, 1H), 7.34-7.25 (m, 1H), 7.15-7.07 (m, 1H), 7.03 (dd, J = 13.0, 8.3 Hz, 1H), 6.98-6.86 (m, 1H), 4.96-3.99 (m, 2H), 3.88-3.58 (m, 2H), 3.56-3.33 (m, 5H), 3.19- 2.99 (m, 1H), 1.95-1.73 (m, 3H), 0.99-0.89 (m, 2H), 0.64-0.55 (m, 2H). [M + H].sup.+ = 480.2 121 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (s, 2H), 7.84 (d, J = 8.2 Hz, 1H), 7.78 (s, 1H), 7.45 (s, 1H), 7.31 (s, 1H), 7.11 (s, 1H), 7.04 (d, J = 7.3 Hz, 1H), 6.92 (d, J = 30.9 Hz, 1H), 4.54-4.18 (m, 2H), 4.11-3.88 (m, 1H), 3.66 (dd, J = 36.7, 10.9 Hz, 1H), 3.54 (s, 4H), 3.29 (s, 2H), 3.19-3.02 (m, 1H), 1.88 (d, J = 7.7 Hz, 1H), 0.94 (d, J = 8.6 Hz, 2H), 0.60 (s, 2H). [M + H].sup.+ = 536.0 122 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.20 (s, 2H), 7.82 (d, J = 8.4 Hz, 1H), 7.76 (s, 1H), 7.56 (s, 1H), 7.36 (s, 1H), 7.17 (s, 1H), 7.02 (s, 2H), 5.20 (s, 1H), 4.20 (dd, J = 13.2, 7.5 Hz, 1H), 4.09-3.86 (m, 1H), 3.81-3.45 (m, 7H), 3.26-3.14 (m, 1H), 1.89 (s, 1H), 0.96 (d, J = 8.1 Hz, 2H), 0.62 (s, 2H). [M + H].sup.+ = 536.0 123 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.79 (s, 1H), 8.30 (s, 1H), 8.15 (dd, J = 9.0, 4.2 Hz, 4H), 7.92 (dd, J = 8.4, 1.9 Hz, 1H), 7.90-7.87 (m, 1H), 6.80 (d, J = 4.9 Hz, 1H), 3.53 (s, 4H), 1.91 (ddd, J = 13.6, 8.4, 5.4 Hz, 1H), 1.40 (s, 3H), 1.05-1.00 (m, 2H), 0.77-0.73 (m, 2H), 0.64-0.59 (m, 4H). [M + H].sup.+ = 453.2 124 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.91 (s, 1H), 8.08 (s, 2H), 7.79 (dd, J = 8.4, 1.9 Hz, 1H), 7.71 (d, J = 1.8 Hz, 1H), 7.64 (s, 1H), 7.42 (s, 1H), 7.18-7.11 (m, 2H), 7.08 (d, J = 8.5 Hz, 1H), 6.76 (d, J = 8.2 Hz, 1H), 3.51 (s, 4H), 3.17 (d, J = 13.7 Hz, 4H), 2.70-2.61 (m, 1H), 2.22-2.02 (m, 4H), 1.99-1.89 (m, 1H), 0.97-0.90 (m, 2H), 0.61-0.52 (m, 2H). [M + H].sup.+ = 496.1 125 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.49 (s, 1H), 8.20 (s, 2H), 8.05 (s, 1H), 7.71 (dd, J = 11.6, 1.7 Hz, 1H), 7.63 (s, 1H), 7.21-7.10 (m, 2H), 7.08 (s, 1H), 6.68 (d, J = 6.6 Hz, 1H), 4.99 (t, J = 7.3 Hz, 1H), 4.01 (q, J = 6.7 Hz, 1H), 3.77 (q, J = 7.2 Hz, 1H), 3.55 (s, 4H), 2.24 (dq, J = 13.0, 6.7 Hz, 1H), 1.87 (p, J = 6.9 Hz, 2H), 1.45 (dq, J = 12.2, 8.2 Hz, 1H), 1.33 (s, 3H), 0.70 (s, 2H), 0.61- 0.53 (m, 2H). [M + H].sup.+ = 466.1 126 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.13 (s, 2H), 7.87 (dd, J = 8.3, 1.9 Hz, 1H), 7.79 (d, J = 1.8 Hz, 1H), 7.65 (s, 1H), 7.46 (dd, J = 7.8, 1.5 Hz, 1H), 7.39 (t, J = 8.0 Hz, 1H), 7.20 (dd, J = 8.2, 1.5 Hz, 1H), 7.08 (d, J = 8.3 Hz, 1H), 3.68-3.58 (m, 4H), 3.53 (s, 4H), 3.25-3.15 (m, 4H), 1.87 (t, J = 5.3 Hz, 1H), 0.95-0.86 (m, 2H), 0.64-0.55 (m, 2H). [M + H].sup.+ = 504.1 127 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.17 (s, 1H), 8.15 (s, 2H), 7.95 (s, 1H), 7.63 (dd, J = 11.3, 1.8 Hz, 1H), 7.52-7.45 (m, 1H), 7.22 (t, J = 7.9 Hz, 1H), 7.18-7.12 (m, 2H), 6.80 (d, J = 8.0 Hz, 1H), 3.54 (s, 4H), 2.03-1.91 (m, 1H), 1.56-1.48 (m, 2H), 1.28-1.20 (m, 2H), 0.96-0.86 (m, 2H), 0.66-0.57 (m, 2H). [M + H].sup.+ = 447.3 128 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.21-8.10 (m, 4H), 7.64 (dd, J = 11.2, 1.8 Hz, 1H), 7.49 (d, J = 1.7 Hz, 1H), 7.03-6.98 (m, 1H), 6.98-6.92 (m, 1H), 6.42 (d, J = 11.1 Hz, 1H), 4.10-3.98 (m, 1H), 3.54 (s, 4H), 2.03-1.91 (m, 1H), 1.13 (d, J = 6.6 Hz, 6H), 0.98-0.89 (m, 2H), 0.67-0.58 (m, 2H). [M + H].sup.+ = 442.2 129 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.57 (s, 1H), 8.17 (s, 2H), 7.65 (dd, J = 10.8, 1.8 Hz, 1H), 7.52 (d, J = 1.8 Hz, 1H), 7.27 (s, 1H), 7.07 (t, J = 7.8 Hz, 1H), 6.66 (dd, J = 7.4, 1.5 Hz, 1H), 6.31 (dt, J = 8.1, 1.7 Hz, 1H), 3.55 (s, 4H), 1.99 (ddd, J = 13.7, 8.5, 5.2 Hz, 1H), 1.40 (s, 3H), 0.97-0.88 (m, 2H), 0.79-0.70 (m, 2H), 0.67-0.54 (m, 4H). [M + H].sup.+ = 470.2 130 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.16 (d, J = 6.5 Hz, 3H), 7.63 (dd, J = 11.2, 1.7 Hz, 1H), 7.57 (d, J = 1.8 Hz, 1H), 7.50 (t, J = 1.2 Hz, 1H), 6.94 (t, J = 7.8 Hz, 1H), 6.84-6.75 (m, 1H), 6.49-6.41 (m, 1H), 4.11-4.00 (m, 1H), 3.54 (s, 4H), 2.09-1.97 (m, 1H), 1.15 (d, J = 6.5 Hz, 6H), 0.95- 0.87 (m, 2H), 0.65-0.57 (m, 2H). [M + H].sup.+ = 442.2 131 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.17 (d, J = 7.8 Hz, 1H), 8.07 (s, 2H), 7.88 (s, 1H), 7.62 (d, J = 2.1 Hz, 1H), 7.57 (d, J = 8.6 Hz, 1H), 7.46-7.40 (m, 1H), 7.36 (t, J = 7.7 Hz, 1H), 7.31-7.25 (m, 1H), 6.69 (d, J = 13.4 Hz, 1H), 4.15-4.02 (m, 1H), 3.50 (s, 4H), 1.87 (ddd, J = 13.6, 8.4, 5.3 Hz, 1H), 1.15 (d, J = 6.6 Hz, 6H), 0.97-0.89 (m, 2H), 0.57-0.49 (m, 2H). [M + H].sup.+ = 424.3 132 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.57 (s, 1H), 8.23 (d, J = 2.0 Hz, 1H), 8.13 (s, 2H), 7.92 (dd, J = 8.2, 1.9 Hz, 1H), 7.13-7.04 (m, 2H), 6.81 (s, 1H), 6.67 (dd, J = 7.5, 1.5 Hz, 1H), 6.56 (dd, J = 8.2, 1.5 Hz, 1H), 3.53 (s, 4H), 1.38 (d, J = 5.6 Hz, 12H), 0.76-0.70 (m, 2H), 0.61-0.55 (m, 2H). [M + H].sup.+ = 468.3 133 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.65 (d, J = 2.1 Hz, 1H), 8.39 (s, 1H), 8.13 (d, J = 7.8 Hz, 1H), 8.10-8.05 (m, 3H), 8.01-7.96 (m, 1H), 7.87 (dd, J = 2.1, 0.8 Hz, 1H), 7.45-7.40 (m, 1H), 7.35 (t, J = 7.8 Hz, 1H), 4.10 (dq, J = 13.5, 6.6 Hz, 1H), 3.51 (s, 4H), 1.99 (td, J = 8.4, 4.3 Hz, 1H), 1.17 (d, J = 6.6 Hz, 6H), 1.08-0.99 (m, 2H), 0.63-0.55 (m, 2H). [M + H].sup.+ = 407.3 134 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.22 (s, 2H), 7.96 (s, 1H), 7.72 (dd, J = 10.9, 1.7 Hz, 1H), 7.44 (s, 1H), 7.12 (t, J = 7.8 Hz, 1H), 6.71-6.63 (m, 1H), 6.26 (d, J = 8.3 Hz, 1H), 3.92 (dd, J = 12.4, 7.3 Hz, 2H), 3.77-3.68 (m, 2H), 3.67 (s, 4H), 3.63-3.57 (m, 3H), 3.56 (s, 4H), 3.19 (t, J = 4.7 Hz, 2H), 2.23 (dd, J = 8.5, 3.7 Hz, 1H), 1.93-1.79 (m, 1H). [M + H].sup.+ = 516.0 135 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.59 (s, 1H), 8.20 (s, 2H), 8.02 (s, 1H), 7.76 (dd, J = 11.4, 1.7 Hz, 1H), 7.42 (s, 1H), 7.09 (t, J = 7.8 Hz, 1H), 6.69 (dd, J = 7.4, 1.4 Hz, 1H), 6.36 (dd, J = 8.2, 2.2 Hz, 1H), 4.94 (t, J = 7.5 Hz, 1H), 4.04 (q, J = 7.5 Hz, 1H), 3.78 (q, J = 7.6 Hz, 1H), 3.55 (s, 4H), 2.19 (td, J = 12.3, 7.3 Hz, 1H), 1.97-1.83 (m, 2H), 1.55 (dq, J = 12.2, 8.2 Hz, 1H), 1.40 (s, 3H), 0.74 (d, J = 11.2 Hz, 2H), 0.63-0.55 (m, 2H). [M + H].sup.+ = 500.0 136 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.76 (s, 1H), 8.26 (s, 1H), 8.17 (s, 2H), 7.89 (d, J = 4.9 Hz, 1H), 7.59 (dd, J = 10.6, 1.7 Hz, 1H), 7.49 (d, J = 1.2 Hz, 1H), 6.62 (d, J = 4.9 Hz, 1H), 3.54 (s, 4H), 2.00 (ddd, J = 13.8, 8.4, 5.3 Hz, 1H), 1.40 (s, 3H), 0.94-0.84 (m, 2H), 0.78-0.70 (m, 2H), 0.64- 0.54 (m, 4H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 174.1, 166.1, 159.3, 157.7, 153.6, 146.3, 145.4, 143.2, 138.2, 129.6 (d, J = 13.2 Hz), 120.6, 113.0, 112.8, 111.2, 41.8, 29.2, 22.8, 14.0, 11.7, 8.9 [M + H].sup.+ = 471.1 137 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.59 (s, 1H), 8.13 (s, 2H), 8.06 (d, J = 1.9 Hz, 1H), 7.95 (dd, J = 8.4, 1.9 Hz, 1H), 7.87 (s, 1H), 7.26-7.15 (m, 3H), 6.82 (dd, J = 6.0, 2.9 Hz, 1H), 4.86 (dd, J = 8.9, 6.5 Hz, 1H), 4.14-4.04 (m, 1H), 3.87-3.77 (m, 1H), 3.53 (s, 4H), 2.23 (td, J = 11.7, 7.2 Hz, 1H), 1.97 (dt, J = 14.8. 7.4 Hz, 2H), 1.85-1.71 (m, 1H), 1.40 (s, 3H), 0.78-0.70 (m, 2H), 0.63-0.55 (m, 2H). [M + H].sup.+ = 482.2 138 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.26 (d, J = 7.8 Hz, 1H), 8.11 (s, 2H), 7.84 (dd, J = 8.3, 1.9 Hz, 1H), 7.80 (s, 1H), 7.72 (d, J = 1.9 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 6.76-6.64 (m, 2H), 4.10- 3.97 (m, 1H), 3.52 (s, 4H), 1.98-1.87 (m, 1H), 1.15 (d, J = 6.6 Hz, 6H), 0.97-0.88 (m, 2H), 0.64- 0.55 (m, 2H). [M + H].sup.+ = 442.3 139 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.59 (s, 1H), 8.11 (s, 2H), 7.84 (dd, J = 8.3, 2.0 Hz, 1H), 7.78 (s, 1H), 7.71 (d, J = 1.9 Hz, 1H), 7.02 (d, J = 8.3 Hz, 1H), 6.74-6.64 (m, 2H), 3.52 (s, 4H), 1.97- 1.85 (m, 1H), 1.37 (s, 3H), 0.97-0.88 (m, 2H), 0.76-0.68 (m, 2H), 0.63-0.54 (m, 4H). [M + H].sup.+ = 454.3 140 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.53 (s, 1H), 8.13 (d, J = 2.5 Hz, 3H), 7.87 (dd, J = 8.4, 2.0 Hz, 1H), 7.60 (s, 1H), 7.44 (s, 1H), 7.26 (d, J = 5.0 Hz, 2H), 7.18-7.07 (m, 2H), 5.01 (t, J = 7.3 Hz, 1H), 4.10-4.00 (m, 1H), 3.81 (q, J = 7.2 Hz, 1H), 3.52 (s, 4H), 2.34 (dq, J = 12.8, 6.5 Hz, 1H), 1.94 (p, J = 6.9 Hz, 2H), 1.60 (dq, J = 12.1, 8.2 Hz, 1H), 1.35 (s, 3H), 0.71 (d, J = 11.1 Hz, 2H), 0.62-0.55 (m, 2H). [M + H].sup.+ = 448.3 141 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.89 (s, 1H), 8.08 (s, 2H), 7.79 (d, J = 8.4 Hz, 1H), 7.72 (s, 1H), 7.66 (s, 1H), 7.38 (s, 1H), 7.18 (t, J = 8.0 Hz, 1H), 7.13 (d, J = 8.4 Hz, 1H), 7.09 (d, J = 7.6 Hz, 1H), 6.82 (d, J = 7.3 Hz, 1H), 3.51 (s, 4H), 1.95 (s, 1H), 1.64 (s, 4H), 0.97-0.92 (m, 2H), 0.56 (d, J = 3.8 Hz, 2H). [M + H].sup.+ = 429.1 142 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (s, 2H), 8.01 (s, 1H), 7.63 (d, J = 11.3 Hz, 1H), 7.48 (s, 1H), 7.24 (t, J = 7.9 Hz, 1H), 6.83-6.59 (m, 3H), 5.17 (s, 1H), 4.13 (s, 1H), 3.81 (s, 1H), 3.74 (s, 1H), 3.54 (s, 4H), 3.53-3.38 (m, 3H), 1.99 (s, 1H), 0.94 (d, J = 8.8 Hz, 2H), 0.63 (s, 2H). [M + H].sup.+ = 520.1 143 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.50 (s, 1H), 8.16 (s, 2H), 7.66-7.60 (m, 1H), 7.56 (s, 1H), 7.50 (s, 1H), 6.93 (t, J = 7.8 Hz, 1H), 6.78 (t, J = 6.0 Hz, 1H), 6.45 (t, J = 8.3 Hz, 1H), 3.54 (s, 4H), 2.03 (s, 1H), 1.38 (s, 3H), 0.91 (dd, J = 8.4, 2.1 Hz, 2H), 0.76-0.70 (m, 2H), 0.65-0.56 (m, 4H). [M + H].sup.+ = 454.1 144 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.15 (s, 2H), 7.96 (s, 1H), 7.63 (dd, J = 11.4, 1.6 Hz, 1H), 7.49 (s, 1H), 7.23 (t, J = 7.8 Hz, 1H), 6.77 (dd, J = 15.0, 7.8 Hz, 2H), 6.63 (s, 1H), 4.67-3.56 (m, 5H), 3.54 (s, 4H), 3.20 (s, 2H), 2.07-1.93 (m, 1H), 0.96-0.90 (m, 2H), 0.65-0.58 (m, 2H). [M + H].sup.+ = 520.0 145 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.19 (s, 2H), 8.05 (d, J = 1.6 Hz, 1H), 7.72 (d, J = 12.7 Hz, 2H), 7.21 (t, J = 7.8 Hz, 1H), 6.71 (t, J = 7.9 Hz, 2H), 6.54 (s, 1H), 4.99 (t, J = 7.4 Hz, 1H), 4.07-3.97 (m, 1H), 3.77 (q, J = 7.1 Hz, 1H), 3.55 (s, 12H), 2.25 (dq, J = 13.4, 6.7 Hz, 1H), 1.88 (p, J = 6.8 Hz, 2H), 1.46 (dq, J = 12.4, 8.1 Hz, 1H). [M + H].sup.+ = 482.3 146 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.71 (d, J = 2.1 Hz, 1H), 8.62 (s, 1H), 8.57 (dd, J = 8.3, 1.6 Hz, 1H), 8.13 (d, J = 14.3 Hz, 3H), 8.02 (dd, J = 2.2, 1.0 Hz, 1H), 7.39-7.31 (m, 1H), 6.99 (dd, J = 7.5, 1.6 Hz, 1H), 3.52 (s, 4H), 1.96-1.85 (m, 1H), 1.45 (s, 3H), 1.14-1.04 (m, 2H), 0.74 (q, J = 4.6 Hz, 2H), 0.65 (td, J = 5.8, 4.0 Hz, 2H), 0.62-0.56 (m, 2H). [M + H].sup.+ = 453.3 147 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.78 (s, 1H), 8.55 (s, 1H), 8.17 (s, 2H), 7.76 (d, J = 5.0 Hz, 1H), 7.59 (dd, J = 10.7, 1.5 Hz, 1H), 7.48 (s, 1H), 6.67 (t, J = 4.6 Hz, 1H), 3.54 (s, 4H), 2.04 (td, J = 8.4, 4.3 Hz, 1H), 1.38 (s, 3H), 0.94-0.84 (m, 2H), 0.74 (d, J = 11.1 Hz, 2H), 0.64-0.60 (m, 2H), 0.60- 0.54 (m, 2H). [M + H].sup.+ = 455.3 148 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.19-8.05 (m, 3H), 7.88 (dd, J = 8.3, 1.9 Hz, 1H), 7.83 (d, J = 1.9 Hz, 1H), 7.35 (s, 1H), 7.16 (d, J = 8.4 Hz, 1H), 6.81 (dd, J = 11.2, 2.7 Hz, 1H), 6.54 (dd, J = 8.6, 2.7 Hz, 1H), 4.05 (dq, J = 13.6, 6.6 Hz, 1H), 3.52 (s, 4H), 1.99-1.85 (m, 1H), 1.84-1.71 (m, 1H), 1.16 (d, J = 6.6 Hz, 6H), 1.02-0.95 (m, 2H), 0.95-0.89 (m, 2H), 0.69-0.58 (m, 2H), 0.52- 0.37 (m, 2H). [M + H].sup.+ = 464.3 149 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.53 (s, 1H), 8.38 (s, 1H), 8.18 (s, 2H), 8.16 (d, J = 1.9 Hz, 1H), 7.89 (d, J = 1.8 Hz, 1H), 7.23 (d, J = 7.4 Hz, 3H), 6.83 (dd, J = 7.2, 2.3 Hz, 1H), 3.55 (s, 4H), 1.90 (ddd, J = 13.2, 8.3, 5.2 Hz, 1H), 1.34 (s, 3H), 0.93-0.86 (m, 2H), 0.74-0.68 (m, 2H), 0.64-0.60 (m, 2H), 0.60-0.55 (m, 2H). [M + H].sup.+ = 443.2 150 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.64 (s, 1H), 8.27 (s, 1H), 8.16 (s, 2H), 7.99 (d, J = 5.6 Hz, 1H), 7.92 (dd, J = 8.2, 1.9 Hz, 1H), 7.75 (d, J = 1.8 Hz, 1H), 7.21 (d, J = 8.2 Hz, 1H), 6.44 (d, J = 5.6 Hz, 1H), 3.54 (s, 4H), 1.91-1.79 (m, 1H), 1.39 (s, 3H), 0.89 (dd, J = 8.4, 1.9 Hz, 2H), 0.78-0.70 (m, 2H), 0.65-0.56 (m, 4H). [M + H].sup.+ = 453.2 151 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.23 (s, 1H), 8.89 (s, 1H), 8.51 (d, J = 3.3 Hz, 2H), 8.11 (s, 2H), 7.78 (d, J = 8.1 Hz, 2H), 6.66 (d, J = 8.1 Hz, 1H), 3.52 (s, 4H), 1.91 (s, 1H), 1.23 (s, 3H), 0.97 (d, J = 8.3 Hz, 2H), 0.65-0.55 (m, 4H), 0.55-0.48 (m, 2H). [M + H].sup.+ = 453.1 152 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.53 (s, 1H), 8.68 (s, 1H), 8.17 (s, 2H), 7.82 (d, J = 5.1 Hz, 1H), 7.60 (dd, J = 10.7, 1.6 Hz, 1H), 7.49 (s, 1H), 6.80-6.72 (m, 1H), 3.54 (s, 4H), 2.10-1.99 (m, 1H), 1.64-1.56 (m, 2H), 1.33-1.26 (m, 2H), 0.94-0.84 (m, 2H), 0.63-0.54 (m, 2H). [M + H].sup.+ = 466.4 153 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.35 (s, 1H), 8.18 (s, 2H), 7.96 (d, J = 4.9 Hz, 1H), 7.61 (dd, J = 10.7, 1.6 Hz, 1H), 7.49 (s, 1H), 6.69 (d, J = 4.9 Hz, 1H), 3.71-3.63 (m, 4H), 3.61-3.57 (m, 2H), 3.55 (s, 4H), 3.24-3.18 (m, 2H), 2.02 (ddd, J = 13.9, 8.5, 5.4 Hz, 1H), 0.89 (dd, J = 8.4, 2.0 Hz, 2H), 0.63-0.52 (m, 2H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 174.1, 165.8, 164.8, 158.5 (d, J = 244.9 Hz), 153.7, 146.9, 144.0, 143.3, 138.4 (d, J = 7.1 Hz), 129.4 (d, J = 13.4 Hz), 120.6, 113.0, 112.8, 112.1, 110.6, 66.6, 66.4, 47.0, 41.9, 41.8, 11.7 (d, J = 2.8 Hz), 9.0, 8.9 [M + H].sup.+ = 487.1 154 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.36 (s, 1H), 8.18 (s, 2H), 7.97 (d, J = 4.9 Hz, 1H), 7.61 (d, J = 10.7 Hz, 1H), 7.49 (s, 1H), 6.76 (d, J = 4.9 Hz, 1H), 4.71 (s, 1H), 4.07 (s, 1H), 3.82-3.76 (m, 1H), 3.66 (d, J = 6.7 Hz, 1H), 3.55 (s, 4H), 3.50 (d, J = 11.5 Hz, 1H), 3.36 (d, J = 12.0 Hz, 1H), 2.09- 1.95 (m, 1H), 1.89 (s, 1H), 1.82 (d, J = 9.4 Hz, 1H), 0.89 (ddt, J = 8.0, 5.1, 3.1 Hz, 2H), 0.61-0.55 (m, 2H). [M + H].sup.+ = 499.2 155 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.35 (s, 1H), 8.18 (s, 2H), 7.95 (d, J = 4.9 Hz, 1H), 7.61 (d, J = 10.7 Hz, 1H), 7.49 (s, 1H), 6.68 (d, J = 4.9 Hz, 1H), 4.92 (s, 1H), 4.62 (s, 1H), 3.84 (d, J = 7.4 Hz, 1H), 3.81-3.76 (m, 1H), 3.55 (s, 4H), 3.20 (dd, J = 9.8, 1.2 Hz, 1H), 3.06 (d, J = 9.8 Hz, 1H), 2.07- 1.97 (m, 1H), 1.92 (s, 1H), 1.89 (s, 1H), 0.89 (ddt, J = 8.1, 5.1, 3.1 Hz, 2H), 0.61-0.55 (m, 2H). [M + H].sup.+ = 499.2 156 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.64 (s, 1H), 8.17 (s, 2H), 7.82 (d, J = 5.0 Hz, 1H), 7.60 (dd, J = 10.8, 1.7 Hz, 1H), 7.48 (d, J = 1.3 Hz, 1H), 6.67 (dd, J = 4.9, 4.1 Hz, 1H), 3.67 (s, 4H), 3.59 (q, J = 5.3 Hz, 2H), 3.54 (s, 4H), 3.30 (s, 2H), 2.07 (ddd, J = 13.7, 8.5, 5.3 Hz, 1H), 0.93-0.87 (m, 2H), 0.63-0.54 (m, 2H). [M + H].sup.+ = 471.4 157 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.66 (s, 1H), 8.27 (s, 1H), 8.19 (s, 2H), 7.97 (d, J = 5.6 Hz, 1H), 7.70-7.65 (m, 1H), 7.53 (s, 1H), 6.18 (dd, J = 5.6, 1.6 Hz, 1H), 3.55 (s, 4H), 1.95 (s, 1H), 1.39 (s, 3H), 0.96-0.90 (m, 2H), 0.76-0.71 (m, 2H), 0.64 (d, J = 5.1 Hz, 2H), 0.62-0.58 (m, 2H). [M + H].sup.+ = 471.0 158 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.16 (s, 2H), 7.68 (s, 1H), 7.62 (dd, J = 11.4, 1.6 Hz, 1H), 7.50 (s, 1H), 7.01 (t, J = 7.9 Hz, 1H), 6.69 (t, J = 5.9 Hz, 1H), 6.54 (t, J = 8.2 Hz, 1H), 3.66 (s, 4H), 3.56 (s, 2H), 3.54 (s, 4H), 3.29 (s, 2H), 2.04 (d, J = 5.3 Hz, 1H), 0.97-0.87 (m, 2H), 0.61 (q, J = 5.2, 4.6 Hz, 2H). [M + H].sup.+ = 470.1 159 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.64 (d, J = 16.5 Hz, 1H), 8.17 (s, 2H), 7.83 (dd, J = 8.3, 4.9 Hz, 1H), 7.62-7.57 (m, 1H), 7.48 (s, 1H), 6.70 (dt, J = 17.6, 4.2 Hz, 1H), 4.92 (s, 2H), 3.83-3.68 (m, 2H), 3.54 (s, 4H), 3.44 (dd, J = 58.9, 12.3 Hz, 2H), 2.07 (d, J = 8.5 Hz, 1H), 1.95-1.80 (m, 2H), 0.89 (dt, J = 6.0, 3.0 Hz, 2H), 0.59 (d, J = 3.7 Hz, 2H). [M + H].sup.+ = 483.1 160 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.75 (s, 1H), 8.09 (d, J = 8.5 Hz, 1H), 8.06 (s, 1H), 7.92 (s, 1H), 7.77 (d, J = 7.6 Hz, 1H), 7.42 (t, J = 7.8 Hz, 1H), 7.33 (br s, 1H), 7.30 (d, J = 8.4 Hz, 1H), 6.47 (s, 1H), 5.55 (t, J = 7.2 Hz, 1H), 5.23 (d, J = 7.2 Hz, 2H), 3.68 (t, J = 8.6 Hz, 2H), 3.48 (t, J = 8.5 Hz, 2H), 3.07 (s, 4H), 1.86 (s, 3H), 1.81 (s, 3H), 1.78-1.74 (m, 1H), 0.99 (q, J = 5.6 Hz, 2H), 0.75 (q, J = 5.6 Hz, 2H). [M + H].sup.+ = 471.3 161 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.32-7.20 (m, 3H), 7.54 (s, 1H), 7.32-7.20 (m, 4H), 6.95 (d, J = 7.7 Hz, 1H), 6.50 (s, 1H), 4.98 (d, J = 6.1 Hz, 2H), 4.56 (d, J = 6.1 Hz, 2H), 3.75 (s, 4H), 1.76- 1.72 (m, 1H), 1.68 (s, 3H), 0.99 (q, J = 5.4 Hz, 2H), 0.75 (q, J = 5.4 Hz, 2H). [M + H].sup.+ = 434.4 162 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 8.56 (s, 1H), 8.10 (br s, 2H), 7.79 (d, J = 8.5 Hz, 1H), 7.75 (d, J = 12.3 Hz, 1H), 7.55 (s, 1H), 7.34 (d, J = 7.7 Hz, 1H), 7.29 (t, J = 7.6 Hz, 1H), 7.19 (d, J = 7.5 Hz, 1H), 7.11 (d, J = 8.5 Hz, 1H), 4.73 (t, J = 5.8 Hz, 1H), 3.52 (br s, 6H), 1.97-1.90 (m, 1H), 0.95 (q, J = 5.5 Hz, 2H), 0.78 (d, J = 8.0 Hz, 2H), 0.67 (d, J = 8.0 Hz, 2H), 0.58 (q, J = 5.5 Hz, 2H). [M + H].sup.+ = 434.4 163 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.75 (d, J = 11.3 Hz, 1H), 7.63 (s, 1H), 7.49 (s, 1H), 7.18 (t, J = 8.0 Hz, 1H), 7.06 (d, J = 7.7 Hz, 2H), 6.57 (d, J = 7.4 Hz, 1H), 5.83 (s, 1H), 4.94 (d, J = 6.0 Hz, 2H), 4.53 (d, J = 6.0 Hz, 2H), 3.72 (s, 4H), 1.91-1.78 (m, 1H), 1.65 (s, 3H), 0.91 (q, J = 5.3 Hz, 2H), 0.75 (q, J = 5.3 Hz, 2H). .sup.13C NMR (75 MHz, CDCl.sub.3) δ 176.1, 172.7, 165.6, 157.5, 154.2, 145.2, 138.6, 133.9, 133.8, 131.9, 131.7, 129.6, 122.5, 114.5, 114.2, 112.4, 111.9, 107.6, 80.1, 46.4, 41.9, 22.0, 12.0, 7.9 [M + H].sup.+ = 452.5 164 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.03 (d, J = 4.9 Hz, 1H), 7.89 (br s, 1H), 7.73 (dd, J = 10.6, 1.4 Hz, 1H), 7.62 (s, 1H), 6.80 (d, J = 5.0 Hz, 1H), 6.78 (s, 1H), 6.38 (s, 1H), 3.64 (s, 4H), 2.53 (s, 1H), 2.21 (s, 6H), 1.92-1.83 (m, 1H), 0.91 (q, J = 5.3 Hz, 2H), 0.76 (q, J = 5.3 Hz, 2H). .sup.13C NMR (75 MHz, CDCl.sub.3) δ 176.3, 166.0, 165.3, 158.9, 155.6, 152.5, 146.6, 143.3, 140.7, 136.8, 136.7, 129.1, 128.9, 122.2, 114.3, 114.0, 113.8, 112.2, 53.1, 48.8, 41.9, 25.1, 12.1, 7.7 [M + H].sup.+ = 483.4 165 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.77 (d, J = 11.3 Hz, 1H), 7.65 (s, 1H), 7.47 (d, J = 7.7 Hz, 1H), 7.40 (s, 1H), 7.38-7.30 (m, 1H), 6.89 (d, J = 7.7 Hz, 1H), 5.88 (s, 1H), 4.40 (t, J = 9.5 Hz, 2H), 4.03 (t, J = 9.5 Hz, 2H), 3.72 (s, 4H), 1.89-1.76 (m, 1H), 0.90 (q, J = 5.4 Hz, 2H), 0.77 (q, J = 5.4 Hz, 2H). [M + H].sup.+ = 408.3 166 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.08 (d, J = 4.9 Hz, 1H), 7.79 (d, J = 10.6 Hz, 1H), 7.68 (s, 1H), 6.82 (d, J = 4.9 Hz, 1H), 6.79 (s, 1H), 6.32 (s, 1H), 3.72 (s, 4H), 2.55 (s, 6H), 1.92-1.83 (m, 1H), 0.98-0.86 (m, 2H), 0.82-0.73 (m, 2H). [M + H].sup.+ = 501.3 167 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.58 (s, 1H), 8.11 (s, 2H), 7.85 (dd, J = 8.3, 1.9 Hz, 1H), 7.80 (s, 1H), 7.31 (s, 1H), 7.22 (t, J = 7.8 Hz, 1H), 7.09 (dd, J = 8.2, 1.4 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 6.85 (dd, J = 7.4, 1.4 Hz, 1H), 3.52 (s, 4H), 1.87 (s, 1H), 1.40 (s, 3H), 0.99-0.90 (m, 2H), 0.77- 0.71 (m, 2H), 0.63-0.54 (m, 4H). .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.5, 167.5, 165.8, 144.0, 140.9, 139.2, 132.9, 132.5, 128.0, 127.9, 127.8, 120.2, 119.5, 118.7, 118.0, 41.7, 29.2, 22.9, 14.1, 11.7, 7.2 [M + H].sup.+ = 452.1 168 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.06 (d, J = 5.0 Hz, 1H), 7.77 (dd, J = 10.6, 1.5 Hz, 1H), 7.66 (s, 1H), 7.46 (s, 2H), 6.75 (d, J = 5.0 Hz, 1H), 6.71 (s, 1H), 4.09-3.96 (m, 4H), 3.69 (s, 4H), 1.93- 1.84 (m, 1H), 1.22 (s, 9H), 0.98-0.86 (m, 2H), 0.82-0.73 (m, 2H). [M + H].sup.+ = 542.3 169 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 8.16 (s, 2H), 7.84 (s, 1H), 7.61 (d, J = 11.5 Hz, 1H), 7.48 (s, 1H), 7.22-7.08 (m, 3H), 6.75 (d, J = 7.7 Hz, 1H), 3.53 (s, 4H), 3.33 (s, 4H), 2.04-1.94 (m, 1H), 0.90 (q, J = 5.3 Hz, 2H), 0.60 (q, J = 5.3 Hz, 2H). .sup.13C NMR (75 MHz, d.sub.6-DMSO) δ 173.8, 165.3, 164.2, 156.6 (d, J = 242.4 Hz), 145.6, 140.3, 135.6 (d, J = 6.8 Hz), 131.3, 130.5 (d, J = 12.8 Hz), 128.5, 120.6, 117.0, 116.2, 113.1 (d, J = 21.0 Hz), 112.8, 41.3, 11.3, 8.8 [M + H].sup.+ = 407.3 170 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 8.16 (s, 2H), 7.87 (s, 1H), 7.61 (d, J = 11.3 Hz, 1H), 7.46 (s, 1H), 7.12 (t, J = 8.1 Hz, 1H), 7.04 (s, 1H), 6.84 (d, J = 8.2 Hz, 1H), 6.38 (d, J = 8.0 Hz, 1H), 4.43- 4.35 (m, 2H), 3.97 (t, J = 7.9 Hz, 2H), 3.54 (s, 4H), 2.07-1.93 (m, 1H), 0.93 (q, J = 6.1 Hz, 2H), 0.61 (q, J = 5.7 Hz, 2H). [M + H].sup.+ = 424.3 171 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.76 (dd, J = 11.5, 1.6 Hz, 1H), 7.64 (s, 1H), 7.41 (br s, 2H), 7.25 (t, J = 7.7 Hz, 2H), 6.90-6.81 (m, 2H), 6.76 (s, 1H), 5.88 (s, 1H), 3.99 (br s, 2H), 3.80-3.59 (m, 6H), 2.79-2.45 (m, 4H), 1.91-1.78 (m, 1H), 0.99-0.87 (m, 2H), 0.76 (q, J = 5.3 Hz, 2H). [M + H].sup.+ = 468.4 172 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.04 (d, J = 4.9 Hz, 1H), 7.77 (dd, J = 10.6, 1.6 Hz, 1H), 7.71 (s, 1H), 6.80 (s, 2H), 5.56 (s, 1H), 3.72 (s, 4H), 2.14 (s, 9H), 1.93-1.84 (m, 1H), 1.73 (s, 6H), 0.93 (q, J = 5.2 Hz, 2H), 0.81 (q, J = 5.2 Hz, 2H). [M + H].sup.+ = 551.4 173 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 8.16 (s, 2H), 7.87 (s, 1H), 7.61 (dd, J = 11.4, 1.5 Hz, 1H), 7.47 (s, 1H), 7.42 (s, 1H), 7.19-7.04 (m, 3H), 6.70 (d, J = 7.6 Hz, 1H), 3.53 (s, 4H), 2.03 (s, 9H), 2.00- 1.92 (m, 1H), 1.64 (s, 6H), 0.91 (q, J = 5.2 Hz, 2H), 0.61 (q, J = 5.2 Hz, 2H). [M + H].sup.+ = 516.5 174 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.69 (s, 1H), 7.87 (d, J = 11.3 Hz, 1H), 7.67 (s, 1H), 7.25-7.12 (m, 3H), 6.84 (d, J = 8.0 Hz, 1H), 5.88 (s, 1H), 5.75 (s, 1H), 3.70 (t, J = 8.7 Hz, 2H), 3.51 (t, J = 8.7 Hz, 2H), 3.07 (s, 3H), 2.10 (s, 9H), 1.91-1.78 (m, 1H), 1.71 (s, 6H), 0.91 (q, J = 5.2 Hz, 2H), 0.76 (q, J = 5.2 Hz, 2H). [M + H].sup.+ = 530.5 175 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 9.74 (s, 1H), 8.15 (s, 2H), 7.74 (s, 1H), 7.61 (d, J = 11.5 Hz, 1H), 7.47 (s, 1H), 7.08 (s, 1H), 7.04 (t, J = 8.2 Hz, 1H), 6.91 (d, J = 8.2 Hz, 1H), 6.37 (d, J = 7.9 Hz, 1H), 3.61 (dd, J = 8.8, 5.5 Hz, 1H), 3.54 (s, 4H), 2.86 (t, J = 6.5 Hz, 2H), 2.07-1.94 (m, 2H), 1.78-1.69 (m, 1H), 1.67-1.57 (m, 2H), 0.91 (q, J = 5.1 Hz, 2H), 0.61 (q, J = 5.1 Hz, 2H). [M + H].sup.+ = 451.4 176 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 8.96 (d, J = 6.3 Hz, 1H), 8.61 (s, 1H), 7.95 (s, 1H), 7.71 (dd, J = 11.4, 1.5 Hz, 1H), 7.52 (s, 1H), 7.22 (d, J = 4.8 Hz, 2H), 7.16 (s, 1H), 6.79 (br s, 1H), 5.05-4.88 (m, 1H), 4.73 (t, J = 6.8 Hz, 2H), 4.56 (t, J = 6.8 Hz, 2H), 3.62-3.51 (m, 2H), 3.50-3.41 (m, 2H), 2.95 (s, 3H), 2.05-1.92 (m, 1H), 0.92 (q, J = 5.2 Hz, 2H), 0.63 (q, J = 5.2 Hz, 2H). [M + H].sup.+ = 452.3 177 .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.74 (dd, J = 11.3, 1.6 Hz, 1H), 7.61 (s, 1H), 7.50 (br s, 1H), 7.32- 7.18 (m, 4H), 6.90 (d, J = 7.0 Hz, 1H), 6.66 (d, J = 7.0 Hz, 1H), 5.90 (s, 1H), 5.26-5.15 (m, 1H), 5.00 (t, J = 7.1 Hz, 2H), 4.59 (t, J = 7.1 Hz, 2H), 3.69 (s, 4H), 1.87-1.78 (m, 1H), 0.91 (q, J = 5.3 Hz, 2H), 0.76 (q, J = 5.3 Hz, 2H). [M + H].sup.+ = 438.4 178 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 11.33 (s, 1H), 8.18 (s, 2H), 8.03 (s, 1H), 7.93 (s, 1H), 7.63 (d, J = 11.4 Hz, 1H), 7.49 (s, 1H), 7.37-7.21 (m, 3H), 7.17 (s, 1H), 6.87 (d, J = 7.3 Hz, 1H), 3.54 (s, 4H), 2.04-1.94 (m, 1H), 0.92 (q, J = 5.2 Hz, 2H), 0.62 (q, J = 5.2 Hz, 2H). [M + H].sup.+ = 449.4 179 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 9.81 (s, 1H), 8.16 (s, 1H), 7.84 (s, 1H), 7.76 (s, 1H), 7.62 (d, J = 11.6 Hz, 1H), 7.47 (s, 1H), 7.06-6.93 (m, 2H), 6.93 (s, 1H), 6.43 (d, J = 6.7 Hz, 1H), 4.15-4.10 (m, 1H), 3.54 (s, 4H), 2.34-2.08 (m, 3H), 2.07-1.89 (m, 2H), 0.91 (q, J = 5.3 Hz, 2H), 0.61 (q, J = 5.3 Hz, 2H). [M + H].sup.+ = 465.4 180 .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 9.41 (s, 1H), 8.16 (s, 2H), 7.71 (s, 1H), 7.61 (dd, J = 11.4, 1.5 Hz, 1H), 7.47 (s, 1H), 7.11 (s, 1H), 7.03 (d, J = 5.0 Hz, 2H), 6.43 (br s, 1H), 3.82 (s, 2H), 3.53 (s, 4H), 2.93 (t, J = 3.1 Hz, 1H), 2.09 (br s, 2H), 2.06-1.93 (m, 1H), 1.67-1.55 (m, 2H), 0.90 (q, J = 5.3 Hz, 2H), 0.59 (q, J = 5.3 Hz, 2H). [M + H].sup.+ = 464.4 181 .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.35 (s, 1H), 8.17 (s, 2H), 7.65 (dd, J = 10.8, 1.6 Hz, 1H), 7.53 (s, 1H), 7.39 (s, 1H), 7.12 (t, J = 7.9 Hz, 1H), 6.75 (dd, J = 7.4, 1.4 Hz, 1H), 6.39-6.35 (m, 1H), 3.55 (s, 4H), 1.99 (ddd, J = 13.8, 8.4, 5.3 Hz, 1H), 1.60-1.55 (m, 2H), 1.29-1.24 (m, 2H), 0.94- 0.89 (m, 2H), 0.66-0.60 (m, 2H). [M + H].sup.+ = 481.0
[0486] The following examples are provided as illustrations and in no way limit the scope of this invention.
[0487] The following examples illustrate in detail the preparation of some compounds according to the invention. The structures of the products obtained have been confirmed by NMR spectra.
EXAMPLES
Example 1: compound (7) in Table I
[0488] According to procedure (E), a solution of methyl 2-bromo-3-chlorobenzoate (500 mg, 2.0 mmoles, 1 eq) and potassium cyclopropyltrifluoroborate (445 mg, 3.0 mmoles, 1.5 eq.) in toluene (10 mL) and water (2 mL) was degassed with argon during 5 minutes then tripotassium phosphate (1.08 g, 5.0 mmoles, 2.5 eq.), RuPhos (37.4 mg, 80 μmoles, 0.04 eq.) and palladium(II) acetate (9.1 mg, 40 μmoles, 0.02 eq.) were added. The reaction mixture was heated at 110° C. and stirred for 2 h30 under inert atmosphere. Upon cooling down to room temperature, it was filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic layers were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 3-chloro-2-cyclopropylbenzoate (201 mg, 47%).
[0489] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 7.59 (dd, J=8.0, 1.3 Hz, 1H), 7.46 (dd, J=7.7, 1.3 Hz, 1H), 7.35 (t, J=7.8 Hz, 1H), 3.86 (s, 3H), 1.94 (tt, J=8.5, 5.8 Hz, 1H), 1.08-0.93 (m, 2H), 0.47-0.34 (m, 2H).
[0490] According to procedure (B), methyl 3-chloro-2-cyclopropylbenzoate (200 mg, 949 μmoles, 1 eq.) was placed in methanol (2 mL) and a 4M aqueous solution of NaOH (1.2 mL, 4.75 mmoles, 5 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 2M HCl (10 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 3-chloro-2-cyclopropylbenzoic acid (176 mg, 71%).
[0491] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 13.16 (s, 1H), 7.54 (dd, J=7.9, 1.3 Hz, 1H), 7.43 (dd, J=7.6, 1.3 Hz, 1H), 7.36-7.27 (m, 1H), 1.94 (tt, J=8.5, 5.7 Hz, 1H), 1.08-0.93 (m, 2H), 0.55-0.40 (m, 2H).
[0492] 3-chloro-2-cyclopropylbenzoic acid (170 mg, 865 μmoles, 1 eq.) and 3-methylbutan-1-amine (110 μL, 951 μmoles, 1.1 eq.) were placed in anhydrous N,N-dimethylformamide (2 mL). HATU (329 mg, 865 μmoles, 1 eq.) and DIPEA (226 μL, 1.30 mmole, 1.5 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched with lM aqueous hydrochloric acid and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 3-chloro-2-cyclopropyl-N-(3-methylbutyl)benzamide (168 mg, 73%).
[0493] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.23 (t, J=5.4 Hz, 1H), 7.46 (dd, J=7.9, 1.3 Hz, 1H), 7.27 (t, J=7.8 Hz, 1H), 7.18 (dd, J=7.6, 1.2 Hz, 1H), 3.28-3.19 (m, 2H), 1.92 (tt, J=8.6, 5.7 Hz, 1H), 1.65 (tq, J=13.3, 6.7 Hz, 1H), 1.42 (q, J=7.0 Hz, 2H), 0.98-0.88 (m, 8H), 0.58-0.44 (m, 2H).
[0494] According to route (A1), a mixture of 3-chloro-2-cyclopropyl-N-(3-methylbutyl)benzamide (99.4 mg, 374 μmoles, 1.1 eq.), methyl 4-amino-3-cyclopropyl-benzoate (65 mg, 340 μmoles, 1 eq.), Pd(OAc).sub.2 (2.3 mg, 10.2 μmoles, 3 mol %), rac-BINAP (4.2 mg, 6.8 μmoles, 2 mol %) and K.sub.2CO.sub.3 (141 mg, 1.02 mmole, 3 eq.) in anhydrous toluene (1 mL) was degassed with N.sub.2 and heated at 130° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 3-cyclopropyl-4-({2-cyclopropyl-3-[(3-methylbutypcarbamoyl]phenyl}amino)benzoate (95 mg, 63%).
[0495] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.17 (t, J=5.6 Hz, 1H), 7.67 (dd, J=8.5, 2.0 Hz, 1H), 7.63 (d, J=1.7 Hz, 1H), 7.49 (s, 1H), 7.35-7.22 (m, 2H), 6.98 (dd, J=7.2, 1.4 Hz, 1H), 6.91 (d, J=8.5 Hz, 1H), 3.78 (s, 3H), 3.29-3.21 (m, 2H), 1.98-1.78 (m, 2H), 1.66 (dq, J=13.3, 6.7 Hz, 1H), 1.43 (q, J=7.0 Hz, 2H), 1.07-0.99 (m, 2H), 0.92 (d, J=6.6 Hz, 6H), 0.83-0.75 (m, 2H), 0.70-0.61 (m, 2H), 0.42 (q, J=5.7 Hz, 2H).
[0496] According to procedure (B), methyl 3-cyclopropyl-4-({2-cyclopropyl-3-[(3-methylbutypcarbamoyl]phenyl}amino)benzoate (86.0 mg, 205 μmoles, 1 eq.) was placed in methanol (2 mL) and a 2M aqueous solution of NaOH (1.03 mL, 2.05 mmoles, 10 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 2M HCl (10 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 3-cyclopropyl-4-({2-cyclopropyl-3-[(3-methylbutyl)carbamoyl]phenyl}amino)benzoic acid (73.0 mg, 83%).
[0497] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 12.32 (s, 1H), 8.16 (t, J=5.6 Hz, 1H), 7.70-7.60 (m, 2H), 7.41 (s, 1H), 7.27 (dt, J=15.3, 7.3 Hz, 2H), 6.99-6.91 (m, 2H), 3.29-3.22 (m, 2H), 1.98-1.78 (m, 2H), 1.67 (dp, J=13.0, 6.5 Hz, 1H), 1.43 (q, J=7.0 Hz, 2H), 1.05-0.97 (m, 2H), 0.92 (d, J=6.6 Hz, 6H), 0.86-0.78 (m, 2H), 0.70-0.61 (m, 2H), 0.43 (q, J=5.8 Hz, 2H).
[0498] According to procedure (C), a reaction mixture of 3-cyclopropyl-4-({2-cyclopropyl-3-[(3-methylbutyl)carbamoyl]phenyl}amino)benzoic acid (66 mg, 154 μmoles, 1.0 eq.) and CDI (30.0 mg, 185 μmoles, 1.2 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (53.9 mg, 309 μmoles, 2 eq.) and DIPEA (80.6 μL, 463 μmoles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was triturated in acetonitrile to afford 2-cyclopropyl-3-({2-cyclopropyl-4-[(imidazolidin-2-ylidene)carbamoyl]phenyl}amino)-N-(3-methylbutyl)benzamide (7) (20.0 mg, 26%).
[0499] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.14 (t, J=5.5 Hz, 1H), 8.08 (s, 2H), 7.82 (d, J=8.5 Hz, 2H), 7.26-7.15 (m, 3H), 7.03 (d, J=8.2 Hz, 1H), 6.84 (d, J=6.2 Hz, 1H), 3.51 (s, 4H), 3.25 (q, J=6.5 Hz, 2H), 1.96-1.78 (m, 2H), 1.67 (dp, J=13.3, 6.7 Hz, 1H), 1.43 (q, J=7.0 Hz, 2H), 1.04-0.95 (m, 2H), 0.92 (d, J=6.6 Hz, 6H), 0.87 (d, J=8.6 Hz, 2H), 0.62 (q, J=5.4 Hz, 2H), 0.45 (q, J=5.4 Hz, 2H).
[0500] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.7, 169.6, 165.7, 145.6, 143.1, 141.8, 130.6, 129.6, 129.0, 128.7, 128.2, 127.1, 120.5, 119.0, 114.2, 41.7, 38.4, 37.7, 25.8, 22.9, 11.9, 11.0, 7.3, 6.5
[0501] [M+H].sup.+=474.2
Example 2: compound (25) in Table I
[0502] 3-bromo-2-chlorobenzoic acid (500 mg, 2.1 mmoles, 1 eq.) and cyclopropanamine (173 μL, 2.5 mmoles, 1.2 eq.) were placed in anhydrous N,N-dimethylformamide (5 mL). HATU (1.24 g, 3.1 mmoles, 1.5 eq.) and DIPEA (1.1 mL, 6.2 mmoles, 3 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched with 1M aqueous hydrochloric acid and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 3-bromo-2-chloro-N-cyclopropylbenzamide (375 mg, 60%).
[0503] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.54 (d, J=4.0 Hz, 1H), 7.82 (dd, J=8.0, 1.6 Hz, 1H), 7.40 (dd, J=7.6, 1.6 Hz, 1H), 7.32 (t, J=7.8 Hz, 1H), 2.81 (td, J=7.3, 4.0 Hz, 1H), 0.70 (td, J=7.0, 4.8 Hz, 2H), 0.54-0.49 (m, 2H).
[0504] According to route (A1), a reaction mixture of 3-bromo-2-chloro-N-cyclopropylbenzamide (108 mg, 0.392 mmole, 1.0 eq.), methyl 4-amino-3-cyclopropyl-benzoate (75 mg, 0.392 mmole, 1.0 eq.), BrettPhos Pd G3 (26.7 mg, 29.4 μmoles, 7.5 mol %) and Cs.sub.2CO.sub.3 (153 mg, 0.471 mmole, 1.2 eq.) in anhydrous DMF (2 mL) was degassed with N.sub.2 and heated at 80° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-{[2-chloro-3-(cyclopropylcarbamoyl)phenyl]amino}-3-cyclopropylbenzoate (75 mg, 41%).
[0505] .sup.1H NMR (500 MHz, d.sub.6-DMSO) δ 8.47 (d, J=4.4 Hz, 1H), 7.69 (dd, J=8.5, 2.0 Hz, 1H), 7.63-7.58 (m, 2H), 7.36-7.29 (m, 2H), 7.08 (s, 1H), 6.89 (d, J=8.5 Hz, 1H), 3.79 (s, 3H), 2.82 (td, J=7.3, 3.8 Hz, 1H), 1.88 (s, 1H), 1.01-0.96 (m, 2H), 0.69 (dd, J=7.1, 2.2 Hz, 2H), 0.64 (dd, J=5.4, 1.7 Hz, 2H), 0.53 (dd, J=3.9, 2.4 Hz, 2H).
[0506] According to procedure (B), methyl 4-{[2-chloro-3-(cyclopropylcarbamoyl)phenyl]amino}-3-cyclopropylbenzoate (75 mg, 0.195 mmole, 1 eq.) was placed in methanol (3 mL) and an aqueous solution of 2M NaOH (0.808 mL, 1.62 mmole, 10 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 2M HCl (10 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-{[2-chloro-3-(cyclopropylcarbamoyl)phenyl]amino}-3-cyclopropylbenzoic acid (70 mg, 97%).
[0507] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 12.46 (s, 1H), 8.48 (d, J=4.4 Hz, 1H), 7.69 (dd, J=8.4, 2.0 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.54 (s, 1H), 7.35-7.29 (m, 1H), 7.27 (dd, J=8.1, 1.8 Hz, 1H), 7.04 (dd, J=7.2, 1.8 Hz, 1H), 6.93 (d, J=8.4 Hz, 1H), 2.83 (td, J=7.3, 4.0 Hz, 1H), 1.93-1.84 (m, 1H), 1.01-0.95 (m, 2H), 0.69 (dt, J=7.0, 3.4 Hz, 2H), 0.64 (dd, J=5.4, 1.8 Hz, 2H), 0.53 (dd, J=4.0, 2.3 Hz, 2H).
[0508] According to procedure (C), a reaction mixture of 4-{[2-chloro-3-(cyclopropylcarbamoyl)phenyl]amino}-3-cyclopropylbenzoic acid (70 mg, 188 μmoles, 1.0 eq.) and CDI (36.5 mg, 225 μmoles, 1.2 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (39.4 mg, 225 μmoles, 1.2 eq.) and DIPEA (98 μL, 563 μmoles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-{[2-chloro-3-(cyclopropylcarbamoyl)phenyl]amino}-3-cyclopropyl-N-(imidazolidin-2-ylidene)benzamide (25) (18.2 mg, 22%).
[0509] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.45 (d, J=4.5 Hz, 1H), 8.11 (s, 2H), 7.85 (dd, J=8.3, 1.9 Hz, 1H), 7.79 (d, J=1.8 Hz, 1H), 7.33 (s, 1H), 7.23 (s, 1H), 7.10 (d, J=1.5 Hz, 1H), 7.04 (d, J=8.3 Hz, 1H), 6.92-6.85 (m, 1H), 3.52 (s, 4H), 2.87-2.79 (m, 1H), 1.87 (s, 1H), 0.98-0.91 (m, 2H), 0.70 (td, J=7.1, 4.8 Hz, 2H), 0.60 (dd, J=5.5, 1.8 Hz, 2H), 0.56-0.50 (m, 2H).
[0510] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.5, 168.1, 165.8, 144.0, 140.9, 138.9, 132.9, 132.6, 127.9, 127.8, 120.3, 119.5, 118.8, 118.1, 41.7, 23.1, 11.7, 7.3, 6.1
[0511] [M+H].sup.+=438.0
Example 3: compound (26) in Table I
[0512] 2-methylpropanoic acid (461 mg, 5.23 mmoles, 1.2 eq.) and 3-bromoaniline (475 μL, 4.36 mmoles, 1.0 eq.) were placed in anhydrous N,N-dimethylformamide (10 mL). HATU (2.59 g, 6.54 mmoles, 1.5 eq.) and DIPEA (2.30 mL, 13.1 mmoles, 3.0 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched with 1M aqueous hydrochloric acid and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give N-(3-bromophenyl)-2-methylpropanamide (979 mg, 88%).
[0513] .sup.1H NMR (400 MHz, d.sub.6-DMSO) 3 9.98 (s, 1H), 7.98 (d, J=1.8 Hz, 1H), 7.51 (d, J=7.9 Hz, 1H), 7.26 (t, J=7.9 Hz, 1H), 7.21 (d, J=8.1 Hz, 1H), 2.58 (p, J=6.8 Hz, 1H), 1.10 (d, J=6.8 Hz, 6H).
[0514] According to route (A1), a reaction mixture of N-(3-bromophenyl)-2-methylpropanamide (279 mg, 1.15 mmole, 1.1 eq.), methyl 4-amino-3-cyclopropyl-benzoate (200 mg, 1.05 mmole, 1.0 eq.), BrettPhos Pd G.sub.3 (47.4 mg, 52.3 moles, 5 mol %) and Cs.sub.2CO.sub.3 (409 mg, 1.26 mmole, 1.2 eq.) in anhydrous DMF (3 mL) was degassed with N.sub.2 and heated at 80° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 3-cyclopropyl-4-{[3-(2-methylpropanamido)phenyl]amino}benzoate (368 mg, 99%).
[0515] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.77 (s, 1H), 7.86 (s, 1H), 7.66 (dd, J=8.5, 2.1 Hz, 1H), 7.59 (d, J=1.9 Hz, 1H), 7.54 (d, J=2.0 Hz, 1H), 7.25-7.17 (m, 2H), 7.14 (d, J=8.5 Hz, 1H), 6.85 (d, J=7.3 Hz, 1H), 3.78 (s, 3H), 2.63-2.53 (m, 1H), 1.95 (s, 1H), 1.09 (d, J=6.8 Hz, 6H), 0.98 (dd, J=8.3, 2.0 Hz, 2H), 0.60 (d, J=3.6 Hz, 2H).
[0516] According to procedure (B), methyl 3-cyclopropyl-4-{[3-(2-methylpropanamido)phenyl]amino}benzoate (368 mg, 1.04 mmole, 1 eq.) was placed in methanol (3 mL) and an aqueous solution of 2M NaOH (2.61 mL, 5.21 mmoles, 5 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 2M HCl (10 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 3-cyclopropyl-4-{[3-(2-methylpropanamido)phenyl]amino}benzoic acid (278 mg, 79%).
[0517] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 12.34 (s, 1H), 9.75 (s, 1H), 7.80 (s, 1H), 7.64 (dd, J=8.5, 2.0 Hz, 1H), 7.54 (dd, J=12.8, 1.9 Hz, 2H), 7.24-7.10 (m, 3H), 6.84 (dt, J=7.3, 1.9 Hz, 1H), 2.58 (p, J=6.8 Hz, 1H), 1.95 (tt, J=8.4, 5.4 Hz, 1H), 1.09 (d, J=6.8 Hz, 6H), 0.97 (dd, J=8.3, 2.0 Hz, 2H), 0.63-0.56 (m, 2H).
[0518] According to procedure (C), a reaction mixture of 3-cyclopropyl-4-{[3-(2-methylpropanamido)phenyl]amino}benzoic acid (178 mg, 526 μmoles, 1.0 eq.) and CDI (102 mg, 631 μmoles, 1.2 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (110 mg, 631 μmoles, 1.2 eq.) and DIPEA (276 μL, 1.58 mmole, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel followed by preparative TLC to give 3-cyclopropyl-N-(imidazolidin-2-ylidene)-4-{[3-(2-methylpropanamido)phenyl]amino}benzamide (26) (25.7 mg, 12%).
[0519] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.71 (s, 1H), 8.21 (s, 2H), 7.82-7.73 (m, 1H), 7.69 (s, 2H), 7.51 (s, 1H), 7.13 (dt, J=13.7, 7.3 Hz, 3H), 6.78 (d, J=7.7 Hz, 1H), 3.56 (s, 4H), 2.61-2.54 (m, 1H), 1.98 (d, J=14.4 Hz, 1H), 1.08 (d, J=6.8 Hz, 6H), 0.95 (d, J=8.4 Hz, 2H), 0.58 (d, J=4.0 Hz, 2H).
[0520] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.6, 146.1, 144.0, 140.6, 131.1, 129.5, 127.8, 127.5, 116.0, 114.2, 112.2, 109.9, 41.9, 35.3, 19.9, 11.6, 7.6
[0521] [M+H].sup.+=406.0
Example 4: compound (41) in Table I
[0522] According to procedure (E), a solution of methyl 4-amino-3-bromobenzoate (3.00 g, 12.8 mmoles, 1 eq.) and potassium cyclopropyltrifluoroborate (2.84 g, 19.2 mmoles, 1.5 eq.) in toluene (52.5 mL) and water (13.5 mL) was degassed with argon during 5 minutes then tripotassium phosphate (6.88 g, 31.9 mmoles, 2.5 eq.), RuPhos (239 mg, 511 μmoles, 0.04 eq.) and palladium(II) acetate (57.9 mg, 256 μmoles, 0.02 eq.) were added. The reaction mixture was heated at 110° C. and stirred for 2 h30 under inert atmosphere. Upon cooling down to room temperature, it was filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic layers were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-amino-3-cyclopropylbenzoate (2.02 g, 81%). NMR (400 MHz, d.sub.6-DMSO) δ 7.53 (dd, J=8.4, 2.0 Hz, 1H), 7.42 (d, J=1.9 Hz, 1H), 6.63 (d, J=8.4 Hz, 1H), 5.87 (s, 2H), 3.73 (s, 3H), 1.65 (tt, J=8.3, 5.4 Hz, 1H), 0.95-0.82 (m, 2H), 0.54-0.40 (m, 2H).
[0523] 3-Bromophenol (701 mg, 3.97 mmoles, 1.2 eq.) was placed in N,N-dimethylformamide (4 mL) with Cs.sub.2CO.sub.3 (1.3 g, 3.97 mmoles, 1.2 eq.). Upon addition of (3-bromopropyl)cyclohexane (715 mg, 3.31 mmoles, 1 eq.), the reaction mixture was stirred at room temperature for 16 hours under an inert atmosphere of argon. To the reaction mixture was added a saturated aqueous solution of NaHCO.sub.3 and it was extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 1-bromo-3-(3-cyclohexylpropoxy)benzene (882 mg, 90%).
[0524] .sup.1H NMR (500 MHz, d.sub.6-DMSO) δ 7.22 (t, J=8.1 Hz, 1H), 7.14-7.08 (m, 2H), 6.93 (dd, J=8.3, 2.3 Hz, 1H), 3.95 (t, J=6.5 Hz, 2H), 1.68 (tt, J=15.1, 9.2 Hz, 7H), 1.32-1.06 (m, 6H), 0.92-0.82 (m, 2H).
[0525] According to procedure (A1), a reaction mixture of 1-bromo-3-(3-cyclohexylpropoxy)benzene (547 mg, 1.84 mmole, 1.1 eq.), methyl 4-amino-3-cyclopropyl-benzoate (320 mg, 1.67 mmole, 1 eq.), BrettPhos Pd G3 (31.9 mg, 33.5 μmoles, 2 mol %) and Cs.sub.2CO.sub.3 (818 mg, 2.51 mmoles, 1.5 eq.) in anhydrous DMF (8 mL) was degassed with N.sub.2 and heated at 80° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropylbenzoate (1.35 g, 80%).
[0526] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 7.82 (s, 1H), 7.66 (dd, J=8.5, 2.0 Hz, 1H), 7.54 (d, J=2.0 Hz, 1H), 7.24-7.14 (m, 2H), 6.76 (d, J=7.9 Hz, 1H), 6.73 (t, J=2.1 Hz, 1H), 6.56 (dd, J=8.1, 2.2 Hz, 1H), 3.92 (t, J=6.5 Hz, 2H), 3.78 (s, 3H), 1.94 (ddd, J=13.8, 8.3, 5.4 Hz, 1H), 1.75-1.58 (m, 7H), 1.35-1.08 (m, 6H), 1.04-0.94 (m, 2H), 0.88 (q, J=10.0, 9.3 Hz, 2H), 0.65-0.56 (m, 2H).
[0527] According to procedure (B), methyl 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropylbenzoate (575 mg, 1.34 mmole, 1 eq.) was placed in methanol (10 mL) and an aqueous solution of 2M NaOH (4.7 mL, 9.4 mmoles, 7 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 2M HCl (7 mL, 14 mmoles, 10.5 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropylbenzoic acid (540 mg, 97%).
[0528] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 12.37 (s, 1H), 7.76 (s, 1H), 7.64 (dd, J=8.5, 2.0 Hz, 1H), 7.52 (d, J=1.9 Hz, 1H), 7.18 (t, J=8.6 Hz, 2H), 6.74 (d, J=7.9 Hz, 1H), 6.71 (d, J=2.1 Hz, 1H), 6.53 (dd, J=8.1, 2.1 Hz, 1H), 3.91 (t, J=6.5 Hz, 2H), 1.94 (ddd, J=13.6, 8.4, 5.4 Hz, 1H), 1.75-1.58 (m, 7H), 1.35-1.09 (m, 6H), 0.98 (dd, J=4.0, 2.0 Hz, 2H), 0.88 (q, J=10.1, 9.3 Hz, 2H), 0.65-0.56 (m, 2H).
[0529] According to procedure (C), a reaction mixture of 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropylbenzoic acid (150 mg, 362 μmoles, 1 eq.) and CDI (70.5 mg, 435 μmoles, 1.2 eq.) in anhydrous DMF (3.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of guanidinium carbonate (2:1 salt) (130 mg, 724 μmoles, 2 eq.) and DIPEA (158 μL, 905 μmoles, 2.5 eq) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropyl-N-(diaminomethylidene)benzamide (135 mg, 82%).
[0530] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 7.79 (d, J=8.4 Hz, 1H), 7.70 (s, 1H), 7.57 (s, 1H), 7.12 (dd, J=11.2, 8.5 Hz, 2H), 6.64 (d, J=8.0 Hz, 1H), 6.60 (s, 1H), 6.41 (d, J=8.2 Hz, 1H), 3.89 (t, J=6.4 Hz, 2H), 2.00-1.88 (m, 1H), 1.68 (t, J=13.7 Hz, 7H), 1.34-1.09 (m, 6H), 0.91 (dd, J=28.4, 9.6 Hz, 4H), 0.58 (d, J=5.0 Hz, 2H).
[0531] To a solution of 4-{[3-cyclohexylpropoxy)phenyl]amino}-cyclopropyl-N-(diaminomethylidene)benzamide (69.0 mg, 151 moles, 1 eq.) and DIPEA (131 μL, 754 μmoles, 5 eq.) in anhydrous DMF (1.5 mL) was added 2-chloroacetyl chloride (23.7 μL, 226 μmoles, 1.5 eq.). The resulting reaction mixture was stirred at room temperature for 2 hours and then heated at 90° C. and stirred for 2 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with DCM. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-{[3-(3-cyclohexylpropoxy)phenyl]amino }-3-cyclopropyl-N-[(2E)-4-oxoimidazolidin-2-ylidene]benzamide (41) (4.0 mg, 5%).
[0532] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 11.24 (s, 1H), 9.35 (s, 1H), 7.81 (d, J=9.6 Hz, 1H), 7.75 (s, 2H), 7.16 (t, J=8.2 Hz, 2H), 6.78-6.64 (m, 2H), 6.50 (d, J=8.5 Hz, 1H), 4.06 (s, 2H), 3.91 (t, J=6.5 Hz, 2H), 1.93 (d, J=13.8 Hz, 1H), 1.67 (d, J=14.8 Hz, 7H), 1.30-1.16 (m, 6H), 0.98 (d, J=8.6 Hz, 2H), 0.86 (s, 2H), 0.61 (s, 2H). [M+H].sup.+=475.1
Example 5: compound (45) in Table I
[0533] 3-bromo-2-chlorobenzoic acid (200 mg, 832 μmoles, 1 eq.) and morpholine (87.0 mg, 999 μmoles, 1.2 eq.) were placed in anhydrous N,N-dimethylformamide (4 mL). HATU (495 mg, 1.25 mmole, 1.5 eq.) and DIPEA (438 μL, 2.50 mmoles, 3 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched with 1M aqueous hydrochloric acid and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-(3-bromo-2-chlorobenzoyl)morpholine (216 mg, 85%).
[0534] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 7.84 (dd, J=7.8, 1.7 Hz, 1H), 7.46-7.33 (m, 2H), 3.66 (qd, J=8.3, 7.2, 3.8 Hz, 4H), 3.56-3.51 (m, 2H), 3.15-3.10 (m, 2H).
[0535] The experimental set-up was dried with a heat gun under a nitrogen stream, kept under inert atmosphere and then cooled down to room temperature. Methyl 3-acetyl-4-aminobenzoate (1.10 g, 5.41 mmoles, 1 eq.) and anhydrous THF (40 mL) were then added and the reaction mixture was cooled down to −10° C. A 3M methylmagnesium bromide solution in diethyl ether (3.79 mL, 11.4 mmoles, 2.1 eq.) was added dropwise and the reaction mixture was stirred at −10° C. during 30 minutes, then additional 3M methylmagnesium bromide solution in diethyl ether (1.80 mL, 5.43 mmoles, 1 eq.) was added and the reaction mixture was further stirred at −10° C. during 30 minutes. The reaction mixture was quenched with a saturated aqueous solution of ammonium chloride at −10° C. then warmed up to room temperature and extracted with DCM. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-amino-3-(2-hydroxypropan-2-yl)benzoate (986 mg, 87%).
[0536] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 7.64 (s, 1H), 7.55 (d, J=8.4 Hz, 1H), 6.64 (d, J=8.4 Hz, 1H), 6.22 (s, 2H), 5.37 (s, 1H), 3.74 (s, 3H), 1.51 (s, 6H).
[0537] According to route (A1), a mixture of 4-(3-bromo-2-chlorobenzoyl)morpholine (218 mg, 717 μmmoles, 1.5 eq.), methyl 4-amino-3-(2-hydroxypropan-2-yl)benzoate (100 mg, 478 moles, 1 eq.), Pd(OAc).sub.2 (3.2 mg, 14.3 μmoles, 3 mol %), rac-BINAP (6.0 mg, 9.6 moles, 2 mol %) and K.sub.2CO.sub.3 (198 mg, 1.43 mmole, 3 eq.) in anhydrous toluene (3 mL) was degassed with N.sub.2 and heated at 110° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-(2-hydroxypropan-2-yl)benzoate (278 mg, 99%).
[0538] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.53 (s, 1H), 7.86 (d, J=2.0 Hz, 1H), 7.79 (dd, J=8.5, 2.0 Hz, 1H), 7.47 (dd, J=8.2, 1.4 Hz, 1H), 7.33 (dd, J=8.3, 4.5 Hz, 2H), 6.95 (dd, J=7.4, 1.4 Hz, 1H), 6.18 (s, 1H), 3.82 (s, 3H), 3.67 (s, 4H), 3.58-3.54 (m, 2H), 3.22-3.18 (m, 2H), 1.58 (d, J=5.8 Hz, 6H).
[0539] According to procedure (B), methyl 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-(2-hydroxypropan-2-yl)benzoate (278 mg, 642 moles, 1 eq.) was placed in methanol (5 mL) and a 2M aqueous solution of NaOH (1.61 mL, 3.21 mmoles, 5 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 2M HCl (10 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-(2-hydroxypropan-2-yl)benzoic acid (240 mg, 55%).
[0540] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 12.56 (s, 1H), 9.48 (s, 1H), 7.86 (d, J=1.9 Hz, 1H), 7.77 (dd, J=8.5, 1.9 Hz, 1H), 7.46 (d, J=8.2 Hz, 1H), 7.33 (d, J=1.9 Hz, 2H), 6.92 (dd, J=7.4, 1.3 Hz, 1H), 6.14 (s, 1H), 3.67 (s, 4H), 3.58-3.54 (m, 2H), 3.22-3.18 (m, 2H), 1.58 (d, J=6.5 Hz, 6H).
[0541] According to procedure (C), a reaction mixture of 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-(2-hydroxypropan-2-yl)benzoic acid (80 mg, 191 moles, 1.0 eq.) and CDI (37.2 mg, 229 moles, 1.2 eq.) in anhydrous DMI (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (63.4 mg, 382 moles, 2 eq.) and DIPEA (100 μL, 573 μmoles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-{[2-chloro-3-(morpholine-4-carbonyl)phenyl]amino}-3-(2-hydroxypropan-2-yl)-N-(imidazolidin-2-ylidene)benzamide (45) (9.9 mg, 11%).
[0542] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.33 (s, 1H), 8.13 (s, 2H), 8.05 (s, 1H), 7.92 (d, J=8.2 Hz, 1H), 7.42 (d, J=7.4 Hz, 1H), 7.29 (dd, J=8.1, 3.9 Hz, 2H), 6.85 (d, J=7.7 Hz, 1H), 6.04 (s, 1H), 3.67 (s, 4H), 3.59-3.50 (m, 6H), 3.21 (d, J=5.1 Hz, 2H), 1.56 (d,, J=10.1 Hz, 6H).
[0543] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 166.3, 140.3, 137.3, 135.5, 128.8, 128.6, 127.1, 118.9, 118.2, 117.9, 116.9, 72.8, 66.6, 66.4, 47.1, 41.9, 41.7, 29.9
[0544] [M+H].sup.+=486.2
Example 6: compound (46) in Table I
[0545] According to procedure (C), a reaction mixture of 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropylbenzoic acid (100 mg, 241 μmoles, 1 eq.) and CDI (47.0 mg, 290 μmoles, 1.2 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (84.4 mg, 483 μmoles, 2 eq.) and DIPEA (126 μL, 724 μmoles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropyl-N-(imidazolidin-2-ylidene)benzamide (27.0 mg, 23%).
[0546] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.08 (s, 2H), 7.79 (dd, J=8.4, 1.9 Hz, 1H), 7.70 (d, J=1.8 Hz, 1H), 7.58 (s, 1H), 7.18-7.07 (m, 2H), 6.65 (d, J=8.0 Hz, 1H), 6.61 (t, J=2.1 Hz, 1H), 6.43 (dd, J=8.1, 2.2 Hz, 1H), 3.89 (t, J=6.5 Hz, 2H), 3.51 (s, 4H), 1.94 (ddd, J=13.7, 8.4, 5.5 Hz, 1H), 1.74-1.58 (m, 7H), 1.21 (ddt, J=36.1, 21.2, 10.0 Hz, 6H), 0.98-0.83 (m, 4H), 0.61-0.52 (m, 2H).
[0547] [M+H].sup.+=431.3
[0548] To a solution of 4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropyl-N-(imidazolidin-2-ylidene)benzamide (84.0 mg, 109 μmoles, 1 eq.) and DIPEA (95 μL, 547 μmoles, 5 eq.) in DCM (2.0 mL) was added acetyl chloride (16 μL, 219 μmoles, 2.0 eq.). The resulting reaction mixture was stirred at room temperature for 20 minutes and then quenched with a saturated aqueous solution of brine and extracted with DCM. The combined organic layers were then dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give N-[(2E)-1-acetylimidazolidin-2-ylidene]-4-{[3-(3-cyclohexylpropoxy)phenyl]amino}-3-cyclopropylbenzamide (46) (12.0 mg, 20%).
[0549] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 9.70 (s, 1H), 7.81 (d, J=8.4 Hz, 1H), 7.73 (d, J=10.6 Hz, 2H), 7.16 (dd, J=14.6, 8.2 Hz, 2H), 6.71 (d, J=8.1 Hz, 1H), 6.67 (s, 1H), 6.48 (d, J=8.4 Hz, 1H), 3.91 (t, J=6.5 Hz, 2H), 3.87-3.78 (m, 2H), 3.59 (t, J=8.5 Hz, 2H), 2.72 (s, 3H), 1.96 (t, J=5.3 Hz, 1H), 1.68 (t, J=14.8 Hz, 7H), 1.33-1.09 (m, 6H), 0.98 (q, J=5.1, 4.5 Hz, 2H), 0.88 (q, J=10.2, 9.2 Hz, 2H), 0.58 (q, J=5.1 Hz, 2H).
[0550] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 176.3, 170.0, 160.0, 158.4, 146.5, 144.8, 131.1, 130.2, 129.6, 128.1, 127.8, 115.8, 111.5, 107.6, 105.5, 68.1, 42.5, 37.2, 33.7, 33.3, 26.6, 26.5, 26.3, 25.9, 11.4, 7.7
[0551] [M+H].sup.+=503.1
Example 7: compound (123) in Table
[0552] 2,3-dichloropyridine-4-carboxylic acid (288 mg, 1.5 mmole, 1 eq.) and 1-methylcyclopropan-1-amine hydrochloride (178 mg, 1.58 mmole, 1.05 eq.) were placed in anhydrous N,N-dimethylformamide (4 mL). HATU (570 mg, 1.5 mmole, 1.0 eq.) and DIPEA (523 μL, 3.75 mmoles, 2.5 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched with 1M aqueous hydrochloric acid and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 2,3-dichloro-N-(1-methylcyclopropyl)pyridine-4-carboxamide (213 mg, 58%).
[0553] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.88 (s, 1H), 8.43 (d, J=4.8 Hz, 1H), 7.46 (d, J=4.8 Hz, 1H), 1.39 (s, 3H), 0.77-0.72 (m, 2H), 0.65-0.60 (m, 2H).
[0554] According to route (A1), a reaction mixture of 2,3-dichloro-N-(1-methylcyclopropyl)pyridine-4-carboxamide (100 mg, 0.408 mmole, 1.0 eq.), methyl 4-amino-3-cyclopropyl-benzoate (78 mg, 0.408 mmole, 1.0 eq.), BrettPhos Pd G3 (18.5 mg, 20.4 moles, 5 mol %) and Cs2CO3 (199 mg, 0.612 mmole, 1.5 eq.) in anhydrous DMF (2 mL) was degassed with N2 and heated at 80° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-({3-chloro-4-[(1-methylcyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropylbenzoate (56 mg, 34%).
[0555] According to procedure (B), methyl 4-({3-chloro-4-[(1-methylcyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropylbenzoate (56 mg, 0.140 mmole, 1 eq.) was placed in methanol (2 mL) and an aqueous solution of 1M NaOH (0.700 mL, 0.700 mmole, 5 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 1M HCl (5 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-({3-chloro-4-[(1-methylcyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropylbenzoic acid (51 mg, 94%).
[0556] According to procedure (C), a reaction mixture of 4-({3-chloro-4-[(1-methylcyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropylbenzoic acid (51 mg, 132 μmoles, 1.0 eq.) and CDI (32.1 mg, 198 moles, 1.5 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (46.2 mg, 264 moles, 2.0 eq.) and DIPEA (69.3 μL, 397 moles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by preparative HPLC to give 3-chloro-2-[(2-cyclopropyl-4-{[imidazolidin-2-ylidene]carbamoyl}phenypamino]-N-(1-methylcyclopropyl)pyridine-4-carboxamide (123) (9.0 mg, 14%).
[0557] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.79 (s, 1H), 8.30 (s, 1H), 8.15 (dd, J=9.0, 4.2 Hz, 4H), 7.92 (dd, J=8.4, 1.9 Hz, 1H), 7.90-7.87 (m, 1H), 6.80 (d, J=4.9 Hz, 1H), 3.53 (s, 4H), 1.91 (ddd, J=13.6, 8.4, 5.4 Hz, 1H), 1.40 (s, 3H), 1.05-1.00 (m, 2H), 0.77-0.73 (m, 2H), 0.64-0.59 (m, 4H).
[0558] [M+H].sup.+=453.2
Example 8: compound (136) in Table I
[0559] According to procedure (E), a solution of methyl 4-amino-3-bromo-5-fluorobenzoate (1.00 g, 4.03 mmoles, 1 eq) and potassium cyclopropyltrifluoroborate (895 mg, 6.04 mmoles, 1.5 eq.) in toluene (16 mL) and water (4 mL) was degassed with argon during 5 minutes then tripotassium phosphate (2.17 g, 10.1 mmoles, 2.5 eq.), RuPhos (75.2 mg, 161 μmoles, 0.04 eq.) and palladium(II) acetate (18.3 mg, 80.6 μmoles, 0.02 eq.) were added. The reaction mixture was heated at 110° C. and stirred for 2h30 under inert atmosphere. Upon cooling down to room temperature, it was filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic layers were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (847 mg, 100%).
[0560] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 7.39 (dd, J=11.8, 1.9 Hz, 1H), 7.28 (d, J=1.7 Hz, 1H), 5.91 (s, 2H), 3.75 (s, 3H), 1.77 (tt, J=8.3, 5.4 Hz, 1H), 1.00-0.90 (m, 2H), 0.59-0.45 (m, 2H).
[0561] According to route (A1), a reaction mixture of 2,3-dichloro-N-(1-methylcyclopropyl)pyridine-4-carboxamide (100 mg, 0.408 mmole, 1.0 eq.), methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (85 mg, 0.408 mmole, 1.0 eq.), BrettPhos Pd G3 (39.0 mg, 40.8 μmoles, 10 mol %) and Cs.sub.2CO.sub.3 (199 mg, 0.612 mmole, 1.5 eq.) in anhydrous DMF (2 mL) was degassed with N.sub.2 and heated at 80° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-({3-chloro-4-[(1-methylcyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropyl-5-fluorobenzoate (40 mg, 24%).
[0562] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.78 (s, 1H), 8.42 (s, 1H), 7.91 (d, J=4.9 Hz, 1H), 7.55 (dd, J=9.9, 1.8 Hz, 1H), 7.33 (s, 1H), 6.67 (d, J=4.9 Hz, 1H), 3.86 (s, 3H), 2.08-2.00 (m, 1H), 1.40 (s, 3H), 0.95-0.88 (m, 2H), 0.77-0.72 (m, 2H), 0.65 (q, J=5.1, 4.5 Hz, 2H), 0.63-0.59 (m, 2H).
[0563] According to procedure (B), methyl 4-({3-chloro-4-[(1-methyl cyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropyl-5-fluorobenzoate (40 mg, 0.096 mmole, 1 eq.) was placed in methanol (2 mL) and an aqueous solution of 1M NaOH (0.479 mL, 0.479 mmole, 5 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 1M HCl (5 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-({3-chloro-4-[(1-methylcyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropyl-5-fluorobenzoic acid (38.6 mg, 100%).
[0564] According to procedure (C), a reaction mixture of 4-({3-chloro-4-[(1-methylcyclopropyl)carbamoyl]pyridin-2-yl}amino)-3-cyclopropyl-5-fluorobenzoic acid (38.6 mg, 96 moles, 1.0 eq.) and CDI (23.3 mg, 144 moles, 1.5 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (33.4 mg, 191 moles, 2.0 eq.) and DIPEA (50.1 μL, 287 moles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by preparative HPLC to give 3-chloro-2-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]-N-(1-methylcyclopropyl)pyridine-4-carboxamide (136) (14.1 mg, 30%).
[0565] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.76 (s, 1H), 8.26 (s, 1H), 8.17 (s, 2H), 7.89 (d, J=4.9 Hz, 1H), 7.59 (dd, J=10.6, 1.7 Hz, 1H), 7.49 (d, J=1.2 Hz, 1H), 6.62 (d, J=4.9 Hz, 1H), 3.54 (s, 4H), 2.00 (ddd, J=13.8, 8.4, 5.3 Hz, 1H), 1.40 (s, 3H), 0.94-0.84 (m, 2H), 0.78-0.70 (m, 2H), 0.64-0.54 (m, 4H).
[0566] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 174.1, 166.1, 159.3, 157.7, 153.6, 146.3, 145.4, 143.2, 138.2, 129.6 (d, J=13.2 Hz), 120.6, 113.0, 112.8, 111.2, 41.8, 29.2, 22.8, 14.0, 11.7, 8.9
[0567] [M+H].sup.+=471.1
Example 9: compound (153) in Table I
[0568] To a solution of 2,3-dichloropyridine-4-carboxylic acid (288 mg, 1.5 mmole, 1 eq.) and anhydrous DMF (2 drops) in anhydrous DCM (10 mL) was added oxalyl dichloride (193 μL, 2.25 mmoles, 1.5 eq.) dropwise. The resulting reaction mixture was stirred at room temperature for 1 hour and concentrated under reduced pressure. The resulting residue was taken up in anhydrous DCM (8 mL). To the resulting solution was added a solution of morpholine (182 μL, 1.50 mmol, 1 eq) and triethylamine (523 μL, 3.75 mmoles, 2.5 eq) in anhydrous DCM (2 mL) dropwise. The resulting reaction mixture was stirred at room temperature for 2h30. The reaction was quenched with water and extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-(2,3-dichloropyridine-4-carbonyl)morpholine (364 mg, 93%).
[0569] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.48 (d. J=4.8 Hz, 1H), 7.54 (d, J=4.8 Hz, 1H), 3.74-3.67 (m, 2H), 3.67-3.58 (m, 2H), 3.53 (ddd, J=16.4, 10.5, 4.8 Hz, 2H), 3.18 (t, J=4.9 Hz, 2H).
[0570] According to route (A1), a reaction mixture of 4-(2,3-dichloropyridine-4-carbonyl)morpholine (75 mg, 0.287 mmole, 1.0 eq.), methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (60 mg, 0.287 mmole, 1.0 eq.), Pd(OAc).sub.2 (7.8 mg, 34.5 moles, 12 mol %), rac-BINAP (14.3 mg, 23 μmoles, 8 mol %) and Cs.sub.2CO.sub.3 (187 mg, 575 moles, 2 eq.) in anhydrous toluene (2 mL) was degassed with N.sub.2 and heated at 110° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-{[3-chloro-4-(morpholine-4-carbonyl)pyridin-2-yl]amino}-3-cyclopropyl-5-fluorobenzoate (64.0 mg, 51%).
[0571] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.51 (s, 1H), 7.98 (d, J=4.9 Hz, 1H), 7.56 (dd, J=10.0, 1.8 Hz, 1H), 7.33 (s, 1H), 6.74 (d, J=4.9 Hz, 1H), 3.87 (s, 3H), 3.72-3.62 (m, 4H), 3.62-3.54 (m, 2H), 3.25-3.18 (m, 2H), 2.06 (ddd, J=13.7, 8.4, 5.2 Hz, 1H), 0.92 (dd, J=8.4, 2.0 Hz, 2H), 0.65 (td, J=5.1, 2.4 Hz, 2H).
[0572] According to procedure (B), methyl 4-{[3-chloro-4-(morpholine-4-carbonyl)pyridin-2-yl]amino}-3-cyclopropyl-5-fluorobenzoate (64.0 mg, 0.148 mmole, 1 eq.) was placed in methanol (2 mL) and an aqueous solution of 1M NaOH (0.738 mL, 0.738 mmole, 5 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 1M HCl (5 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-{[3-chloro-4-(morpholine-4-carbonyl)pyridin-2-yl]amino } -3-cyclopropyl-5-fluorobenzoic acid (62.0 mg, 100%).
[0573] According to procedure (C), a reaction mixture of 4-{[3-chloro-4-(morpholine-4-carbonyl)pyridin-2-yl]amino}-3-cyclopropyl-5-fluorobenzoic acid (62.0 mg, 148 μmoles, 1.0 eq.) and CDI (35.9 mg, 222 μmoles, 1.5 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (51.6 mg, 295 μmoles, 2.0 eq.) and DIPEA (77.4 μL, 443 moles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by preparative HPLC to give 4-{[3-chloro-4-(morpholine-4-carbonyl)pyridin-2-yl]amino}-3-cyclopropyl-5-fluoro-N-[imidazolidin-2-ylidene]benzamide (153) (36.6 mg, 48%).
[0574] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.35 (s, 1H), 8.18 (s, 2H), 7.96 (d, J=4.9 Hz, 1H), 7.61 (dd, J=10.7, 1.6 Hz, 1H), 7.49 (s, 1H), 6.69 (d, J=4.9 Hz, 1H), 3.71-3.63 (m, 4H), 3.61-3.57 (m, 2H), 3.55 (s, 4H), 3.24-3.18 (m, 2H), 2.02 (ddd, J=13.9, 8.5, 5.4 Hz, 1H), 0.89 (dd,J=8.4, 2.0 Hz, 2H), 0.63-0.52 (m, 2H).
[0575] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 174.1, 165.8, 164.8, 158.5 (d, J=244.9 Hz), 153.7, 146.9, 144.0, 143.3, 138.4 (d, J=7.1 Hz), 129.4 (d, J=13.4 Hz), 120.6, 113.0, 112.8, 112.1, 110.6, 66.6, 66.4, 47.0, 41.9, 41.8, 11.7 (d,J=2.8 Hz), 9.0, 8.9
[0576] [M+H].sup.+=487.1
Example 10: compound (163) in Table I
[0577] According to procedure (E), methyl 4-amino-3-bromo-5-fluorobenzoate (4.0 g, 16.13 mmoles, 1 eq) was placed in anhydrous 1,4-dioxane (60 mL) with Pd(dppf)Cl.sub.2.CH.sub.2Cl.sub.2 (1.3 g, 1.61 mmole, 0.1 eq.). Upon addition of K.sub.3PO.sub.4 (12.0 g, 56.44 mmoles, 3.5 eq.) and cyclopropylboronic acid (1.8 g, 20.96 mmoles, 1.3 eq.), the reaction mixture was heated at 100° C. and stirred for 3 hours under an inert atmosphere of argon. Upon filtration over a pad of celite, the reaction mixture was then concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel to afford methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (2.8 g, 83%).
[0578] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.57-7.54 (m, J=4.8 Hz, 2H), 4.40 (br s, 2H), 3.85 (s, 3H), 1.76-1.60 (m, 1H), 1.03-0.88 (m, 2H), 0.69-0.60 (m, 2H).
[0579] 3-methyloxetane-3-carboxylic acid (1 g, 8.61 mmoles, 1 eq.) was placed in anhydrous dichloromethane (34.5 mL). PyBOP (6.7 g, 12.92 mmoles, 1.5 eq.), DIPEA (5.7 mL, 34.45 mmoles, 4 eq.) and 3-bromoaniline (940 μL, 8.61 mmoles, 1 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was then concentrated under reduced pressure and the resulting residue was diluted with ethyl acetate. The organic phase was washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to afford N-(3-bromophenyl)-3-methyloxetane-3-carboxamide (1.3 g, 56%).
[0580] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.83 (t, J=1.9 Hz, 1H), 7.71 (br s, 1H), 7.50-7.44 (m, 1H), 7.30-7.17 (m, 3H), 4.92 (d, J=6.2 Hz, 1H), 4.58 (d, J=6.3 Hz, 2H), 1.65 (s, 3H).
[0581] According to route (A1), a reaction mixture of methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (542 mg, 2.59 mmoles, 1 eq.), N-(3-bromophenyl)-3-methyloxetane-3-carboxamide (700 mg, 2.59 mmoles, 1 eq.), Pd.sub.2(dba).sub.3 (237 mg, 0.26 mmoles, 0.1 eq.), XPhos (247 mg, 0.52 mmoles, 0.2 eq.) and K.sub.2CO.sub.3 (1.4 g, 10.37 mmoles, 4 eq.) in t-BuOH (10.5 mL) was heated at 90° C. and stirred for 16 hours under an inert atmosphere of argon. The reaction mixture was then concentrated under reduced pressure and the resulting residue was diluted with dichloromethane. The organic phase was washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to afford methyl 3-cyclopropyl-5-fluoro-4-{[3-(3-methyloxetane-3-amido)phenyl]amino}benzoate (694 mg, 67%).
[0582] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.63 (dd, J=11.1, 1.8 Hz, 1H), 7.52 (s, 2H), 7.19 (t, J=8.0 Hz, 1H), 6.99 (d, J=7.9 Hz, 1H), 6.59 (d, J=8.0 Hz, 1H), 5.94 (s, 1H), 4.93 (d, J=6.0 Hz, 2H), 4.56 (d, J=6.1 Hz, 2H), 3.90 (s, 3H), 1.88-1.79 (m, 1H), 1.65 (s, 3H), 0.96 (q, J =6.0 Hz, 2H), 0.72 (q, J=6.0 Hz, 2H).
[0583] According to procedure (B), methyl 3-cyclopropyl-5-fluoro-4-{[3-(3-methyloxetane-3-amido)phenyl]amino}benzoate (694 mg, 1.74 mmole, 1 eq.) was placed in a mixture of THF (10 mL), methanol (1.9 mL) and water (1.9 mL), and LiOH.H.sub.2O (365 mg, 8.71 mmoles, 5 eq.) was added. The reaction mixture was stirred for 16 hours at room temperature. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 6M HCl (5 eq.), the aqueous phase was extracted with dichloromethane. The combined organic phases were washed with a saturated aqueous solution of brine, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 3-cyclopropyl-5-fluoro-4-{[3-(3-methyloxetane-3-amido)phenyl]amino}benzoic acid (537 mg, 80%).
[0584] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.71 (s, 1H), 7.67 (dd, J=11.0, 1.7 Hz, 1H), 7.60 (br s, 1H), 7.31 (br s, 1H), 7.21 (t, J=8.1 Hz, 1H), 7.04 (d, J=7.9 Hz, 1H), 6.63 (d, J=8.2 Hz, 1H), 6.05 (s, 1H), 4.97 (d, J=6.1 Hz, 2H), 4.57 (d, J=6.1 Hz, 2H), 1.88-1.78 (m, 1H), 1.66 (s, 3H), 0.96 (q, J=5.4 Hz, 2H).), 0.73 (q. J=5.4 Hz, 2H).
[0585] According to procedure (C), a reaction mixture of 3-cyclopropyl-5-fluoro-4-{[3-(3-methyloxetane-3-amido)phenyl]amino}benzoic acid (200 mg, 520 μmoles, 1.0 eq.) and CDI (101 mg, 620 μmoles, 1.2 eq.) in anhydrous DMF (2.6 mL) was stirred at room temperature for 3 hours. The mixture was then added to a solution of 4,5-dihydro-1H-imidazol-2-amine (66.5 mg, 780 μmoles, 1.5 eq.) and DIPEA (430 μL, 2.60 mmoles, 5 eq.) in anhydrous DMF (2.7 mL) and the resulting mixture was heated at 60° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature and concentrated under reduced pressure. The resulting residue was taken up in EtOAc and this organic phase was then washed with a saturated aqueous solution of NH.sub.4Cl, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give a fraction which, after trituration in diethyl ether, afforded N-{3-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenypamino]phenyl}-3-methyloxetane-3-carboxamide (163) (109 mg, 46%).
[0586] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.75 (d, J=11.3 Hz, 1H), 7.63 (s, 1H), 7.49 (s, 1H), 7.18 (t, J=8.0 Hz, 1H), 7.06 (d, J=7.7 Hz, 2H), 6.57 (d, J=7.4 Hz, 1H), 5.83 (s, 1H), 4.94 (d, J=6.0 Hz, 2H), 4.53 (d, J=6.0 Hz, 2H), 3.72 (s, 4H), 1.91-1.78 (m, 1H), 1.65 (s, 3H), 0.91 (q, J=5.3 Hz, 2H), 0.75 (q, J=5.3 Hz, 2H).
[0587] .sup.13C NMR (75 MHz, CDCl.sub.3) δ 176.1, 172.7, 165.6, 157.5, 154.2, 145.2, 138.6, 133.9, 133.8, 131.9, 131.7, 129.6, 122.5, 114.5, 114.2, 112.4, 111.9, 107.6, 80.1, 46.4, 41.9, 22.0, 12.0, 7.9
[0588] [M+H].sup.+=452.5
Example 11: compound (164) in Table I
[0589] According to procedure (E), methyl 4-amino-3-bromo-5-fluorobenzoate (4.0 g, 16.13 mmoles, 1 eq) was placed in anhydrous 1,4-dioxane (60 mL) with Pd(dppf)Cl.sub.2.CH.sub.2Cl.sub.2 (1.3 g, 1.61 mmole, 0.1 eq.). Upon addition of K.sub.3PO.sub.4 (12.0 g, 56.44 mmoles, 3.5 eq.) and cyclopropylboronic acid (1.8 g, 20.96 mmoles, 1.3 eq.), the reaction mixture was heated at 100° C. and stirred for 3 hours under an inert atmosphere of argon. Upon filtration over a pad of celite, the reaction mixture was then concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel to afford methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (2.8 g, 83%).
[0590] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.57-7.54 (m, J=4.8 Hz, 2H), 4.40 (br s, 2H), 3.85 (s, 3H), 1.76-1.60 (m, 1H), 1.03-0.88 (m, 2H), 0.69-0.60 (m, 2H).
[0591] 2,3-dichloropyridine-4-carboxylic acid (730 mg, 3.80 mmoles, 1 eq.) was placed in anhydrous dichloromethane (15.5 mL). PyBOP (3.0 g, 5.70 mmoles, 1.5 eq.), DIPEA (2.5 mL, 15.20 mmoles, 4 eq.) and bicyclo[1.1.1]pentan-1-amine hydrochloride (500 mg, 4.18 mmoles, 1.1 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was then concentrated under reduced pressure and the resulting residue was diluted with ethyl acetate. The organic phase was washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to afford N-{bicyclo[1.1.1]pentan-1-yl}-2,3-dichloropyridine-4-carboxamide (728 mg, 74%).
[0592] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.34 (d, J=4.8 Hz, 1H), 7.40 (d, J=4.8 Hz, 1H), 7.26 (s, 1H), 6.42 (s, 1H), 2.55 (s, 1H), 2.21 (s, 6H),
[0593] According to route (A1), a reaction mixture of N-{bicyclo[1.1.1]pentan-1-yl}-2,3-dichloropyridine-4-carboxamide (386 mg, 1.5 mmole, 1.0 eq.), methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (314 mg, 1.5 mmole, 1.0 eq.), Pd(OAc).sub.2 (41 mg, 180 μmoles, 12 mol %), rac-BINAP (75 mg, 120 moles, 8 mol %) and Cs.sub.2CO.sub.3 (977 mg, 3.0 mmoles, 2 eq.) in anhydrous toluene (9.5 mL) was degassed with argon and heated at 110° C. for 16 hours under inert atmosphere. The reaction mixture was cooled down to room temperature and concentrated under reduced pressure. The resulting residue was taken up in dichloromethane and this organic phase was then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-{[4-({bicyclo[1.1.1]pentan-1-yl}carbamoyl)-3-chloropyridin-2-yl]amino}-3-cyclopropyl-5-fluorobenzoate (220 mg, 34%).
[0594] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.07 (d, J=5.0 Hz, 1H), 7.65 (dd, J=10.2, 1.7 Hz, 1H), 7.55 (s, 1H), 6.86 (d, J=5.0 Hz, 1H), 6.83 (s, 1H), 6.29 (s, 1H), 3.91 (s, 3H), 2.54 (s, 1H), 2.22 (s, 6H), 1.93-1.84 (m, 1H), 0.96 (q, J=5.3 Hz, 2H), 0.74 (q, J=5.3 Hz, 2H).
[0595] According to procedure (B), methyl 4-{[4-({bicyclo[1.1.1]pentan-1-yl}carbamoyl)-3-chloropyridin-2-yl]amino}-3-cyclopropyl-5-fluorobenzoate (220 mg, 0.51 mmole, 1 eq.) was placed in a mixture of THF (3 mL), methanol (560 μL) and water (560 μL), and LiOH.H.sub.2O (107 mg, 2.56 mmoles, 5 eq.) was added. The reaction mixture was stirred for 16 hours at room temperature. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 6M HCl (5 eq.), the aqueous phase was extracted with dichloromethane. The combined organic phases were washed with a saturated aqueous solution of brine, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-{[4-({bicyclo[1.1.1]pentan-1-yl}carbamoyl)-3-chloropyridin-2-yl]amino}-3-cyclopropyl-5-fluorobenzoic acid (130 mg, 61%).
[0596] .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 9.12 (s, 1H), 8.44 (s, 1H), 7.92 (d, J=4.9 Hz, 1H), 7.51 (dd, J=10.0, 1.6 Hz, 1H), 7.32 (s, 1H), 6.69 (d, J=4.9 Hz, 1H), 2.47 (s, 1H), 2.08 (s, 6H), 2.06-1.99 (m, 1H), 0.91 (q, J=5.3 Hz, 2H), 0.64 (q, J=5.3 Hz, 2H).
[0597] According to procedure (C), a reaction mixture of 4-{[4-({bicyclo[1.1.1]pentan-1-yl}carbamoyl)-3-chloropyridin-2-yl]amino}-3-cyclopropyl-5-fluorobenzoic acid (130 mg, 310 μmoles, 1.0 eq.) and CDI (61 mg, 370 μmoles, 1.2 eq.) in anhydrous DMF (1.6 mL) was stirred at room temperature for 3 hours. The mixture was then added to a solution of 4,5-dihydro-1H-imidazol-2-amine (40 mg, 470 μmoles, 1.5 eq.) and DIPEA (260 μL, 1.56 mmole, 5 eq.) in anhydrous DMF (1.6 mL) and the resulting mixture was heated at 60° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature and concentrated under reduced pressure. The resulting residue was taken up in EtOAc and this organic phase was then washed with a saturated aqueous solution of NH.sub.4Cl, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give N-{bicyclo[1.1.1]pentan-2-yl}-3-chloro-2-[(2-cyclopropyl-6-fluoro-4-{[imidazolidin-2-ylidene]carbamoyl}phenyl)amino]pyridine-4-carboxamide (164) (66 mg, 44%).
[0598] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 8.03 (d, J=4.9 Hz, 1H), 7.89 (br s, 1H), 7.73 (dd, J=10.6, 1.4 Hz, 1H), 7.62 (s, 1H), 6.80 (d, J=5.0 Hz, 1H), 6.78 (s, 1H), 6.38 (s, 1H), 3.64 (s, 4H), 2.53 (s, 1H), 2.21 (s, 6H), 1.92-1.83 (m, 1H), 0.91 (q, J=5.3 Hz, 2H), 0.76 (q. J=5.3 Hz, 2H).
[0599] .sup.13C NMR (75 MHz, CDCl.sub.3) δ 176.3, 166.0, 165.3, 158.9, 155.6, 152.5, 146.6, 143.3, 140.7, 136.8, 136.7, 129.1, 128.9, 122.2, 114.3, 114.0, 113.8, 112.2, 53.1, 48.8, 41.9, 25.1, 12.1, 7.7
[0600] [M+H].sup.+=483.4
Example 12: compound (167) in Table I
[0601] 3-bromo-2-chlorobenzoic acid (500 mg, 2.1 mmoles, 1 eq.) and 1-methylcyclopropan-1-amine hydrochloride (247 mg, 2.2 mmoles, 1.05 eq.) were placed in anhydrous N,N-dimethylformamide (5 mL). HATU (907 mg, 2.3 mmoles, 1.1 eq.) and DIPEA (544 μL, 3.1 mmoles, 1.5 eq.) were added and the resulting reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched with 1M aqueous hydrochloric acid and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 3-bromo-2-chloro-N-(1-methylcyclopropyl)benzamide (370 mg, 62%).
[0602] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.67 (s, 1H), 7.80 (dd, J=7.8, 1.7 Hz, 1H), 7.35 (dd, J=7.5, 1.7 Hz, 1H), 7.30 (t, J=7.7 Hz, 1H), 1.39 (s, 3H), 0.76-0.68 (m, 2H), 0.64-0.56 (m, 2H).
[0603] According to route (A1), a reaction mixture of 3-bromo-2-chloro-N-(1-methylcyclopropyl)benzamide (226 mg, 0.784 mmole, 1.0 eq.), methyl 4-amino-3-cyclopropyl-benzoate (150 mg, 0.784 mmole, 1.0 eq.), BrettPhos Pd G3 (35.6 mg, 39.2 μmoles, 5 mol %) and Cs.sub.2CO.sub.3 (383 mg, 1.18 mmole, 1.5 eq.) in anhydrous DMF (4 mL) was degassed with N.sub.2 and heated at 80° C. for 75 minutes under inert atmosphere. The reaction mixture was cooled down to room temperature, filtered over a pad of celite and the pad was washed with EtOAc. A saturated aqueous solution of brine was then added to the filtrate and the mixture was extracted with EtOAc. The combined organic phases were dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give methyl 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropylbenzoate (77 mg, 25%). .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.61 (s, 1H), 7.70 (dd, J=8.5, 2.1 Hz, 1H), 7.63-7.59 (m, 2H), 7.35-7.29 (m, 2H), 7.04 (dd, J=6.3, 2.7 Hz, 1H), 6.90 (d. J=8.5 Hz, 1H), 3.80 (s, 3H), 1.89 (ddd, J=13.5, 8.3, 5.4 Hz, 1H), 1.40 (s, 3H), 1.02-0.95 (m, 2H), 0.78-0.70 (m, 2H), 0.67-0.62 (m, 2H), 0.62-0.57 (m, 2H).
[0604] According to procedure (B), methyl 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropylbenzoate (77 mg, 0.193 mmole, 1 eq.) was placed in methanol (3 mL) and an aqueous solution of 1M NaOH (0.965 mL, 0.965 mmole, 5 eq.) was added. The reaction mixture was heated at 80° C. and stirred for 3 hours. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 1M HCl (5 eq.), extracted with dichloromethane. The combined organic phases were dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropylbenzoic acid (71 mg, 96%).
[0605] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 12.47 (s, 1H), 8.61 (s, 1H), 7.69 (dd, J=8.4, 2.0 Hz, 1H), 7.60 (d, J=1.9 Hz, 1H), 7.52 (s, 1H), 7.35-7.22 (m, 2H), 6.99 (dd, J=7.2, 1.8 Hz, 1H), 6.93 (d, J=8.4 Hz, 1H), 1.88 (s, 1H), 1.40 (s, 3H), 1.03-0.93 (m, 2H), 0.78-0.70 (m, 2H), 0.66-0.62 (m, 2H), 0.61-0.58 (m, 2H).
[0606] According to procedure (C), a reaction mixture of 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropylbenzoic acid (35 mg, 91 μmoles, 1.0 eq.) and CDI (22.1 mg, 136 μmoles, 1.5 eq.) in anhydrous DMF (1.0 mL) was stirred at room temperature for 1 hour. The mixture was then added to a solution of imidazolidin-2-imine hydrobromide (31.8 mg, 182 μmoles, 2 eq.) and DIPEA (47.6 μL, 273 μmoles, 3 eq.) in anhydrous DMF (1.0 mL) and the resulting mixture was heated at 75° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature, quenched with a saturated aqueous solution of sodium bicarbonate and extracted with EtOAc. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give 4-({2-chloro-3-[(1-methylcyclopropyl)carbamoyl]phenyl}amino)-3-cyclopropyl-N-[imidazolidin-2-ylidene]benzamide (167) (7.7 mg, 18%).
[0607] .sup.1H NMR (400 MHz, d.sub.6-DMSO) δ 8.58 (s, 1H), 8.11 (s, 2H), 7.85 (dd, J=8.3, 1.9 Hz, 1H), 7.80 (s, 1H), 7.31 (s, 1H), 7.22 (t, J=7.8 Hz, 1H), 7.09 (dd, J=8.2, 1.4 Hz, 1H), 7.04 (d, J=8.3 Hz, 1H), 6.85 (dd, J=7.4, 1.4 Hz, 1H), 3.52 (s, 4H), 1.87 (s, 1H), 1.40 (s, 3H), 0.99-0.90 (m, 2H), 0.77-0.71 (m, 2H), 0.63-0.54 (m, 4H).
[0608] .sup.13C NMR (151 MHz, d.sub.6-DMSO) δ 175.5, 167.5, 165.8, 144.0, 140.9, 139.2, 132.9, 132.5, 128.0, 127.9, 127.8, 120.2, 119.5, 118.7, 118.0, 41.7, 29.2, 22.9, 14.1, 11.7, 7.2
[0609] [M+H].sup.+=452.1
Example 13: compound (169) in Table I
[0610] According to procedure (E), methyl 4-amino-3-bromo-5-fluorobenzoate (4.0 g, 16.13 mmoles, 1 eq) was placed in anhydrous 1,4-dioxane (60 mL) with Pd(dppf)Cl.sub.2.CH.sub.2Cl.sub.2 (1.3 g, 1.61 mmole, 0.1 eq.). Upon addition of K.sub.3PO.sub.4 (12.0 g, 56.44 mmoles, 3.5 eq.) and cyclopropylboronic acid (1.8 g, 20.96 mmoles, 1.3 eq.), the reaction mixture was heated at 100° C. and stirred for 3 hours under an inert atmosphere of argon. Upon filtration over a pad of celite, the reaction mixture was then concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel to afford methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (2.8 g, 83%).
[0611] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.57-7.54 (m, J=4.8 Hz, 2H), 4.40 (br s, 2H), 3.85 (s, 3H), 1.76-1.60 (m, 1H), 1.03-0.88 (m, 2H), 0.69-0.60 (m, 2H).
[0612] 3-bromobenzaldehyde (1.2 mL, 10 mmoles, 1 eq.) was placed in water (240 mL). Ethylenediamine (4.0 mL, 60 mmoles, 6 eq.) and pyridinium bromide perbromide (6.4 g, 20 mmoles, 2 eq.) were added and the resulting reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was then treated with an aqueous solution of 3M NaOH and the resulting aqueous phase was extracted with dichloromethane. The combined organic layers were then dried over MgSO.sub.4, filtered and concentrated under reduced pressure to give 2-(3-bromophenyl)-4,5-dihydro-1H-imidazole (1.1 g, 49%).
[0613] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.96-7.94 (m, 1H), 7.70 (d, J=7.7 Hz, 1H), 7.57 (d, J=7.7 Hz, 1H), 7.28 (t, J=7.7 Hz, 1H), 3.80 (s, 4H).
[0614] 2-(3-bromophenyl)-4,5-dihydro-1H-imidazole (1.1 g, 4.88 mmoles, 1 eq.) was placed at 0° C. in a 1/1 mixture of water/dichloromethane (30 mL). NaHCO.sub.3 (1.6 g, 19.55 mmoles, 4 eq.) and Boc2O (1.6 g, 7.33 mmoles, 1.5 eq.) were added and the resulting reaction mixture was stirred at room temperature for 21 hours. Upon decantation, the aqueous layer was extracted with dichloromethane. The combined organic layers were then washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure to afford tert-butyl 2-(3-bromophenyl)-4,5-dihydro-1H-imidazole-1-carboxylate (1.5 g, 94%).
[0615] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.65 (s, 1H), 7.53 (d, J=7.8 Hz, 1H), 7.45 (d, J=7.8 Hz, 1H), 7.25 (t, J=7.8 Hz, 1H), 3.97 (s, 4H), 1.27 (s, 9H).
[0616] According to route (A1), a reaction mixture of methyl 4-amino-3-cyclopropyl-5-fluorobenzoate (418 mg, 2 mmoles, 1 eq.), tert-butyl 2-(3-bromophenyl)-4,5-dihydro-1H-imidazole-1-carboxylate (650 mg, 2 mmoles, 1 eq.), Pd.sub.2(dba).sub.3 (183 mg, 0.2 mmole, 0.1 eq.), XPhos (191 mg, 0.4 mmole, 0.2 eq.) and K.sub.2CO.sub.3 (1.1 g, 8 mmoles, 4 eq.) in t-BuOH (10.5 mL) was heated at 90° C. and stirred for 20 hours under an inert atmosphere of argon. The reaction mixture was then concentrated under reduced pressure and the resulting residue was diluted with ethyl acetate. The organic phase was washed with a saturated aqueous solution of brine, dried over MgSO.sub.4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to afford tert-butyl 2-(3-{[2-cyclopropyl-6-fluoro-4-(methoxycarbonyl)phenyl]amino}phenyl)-4,5-dihydro-1H-imidazole-1-carboxylate (320 mg, 35%).
[0617] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.62 (dd, J=11.0, 1.7 Hz, 1H), 7.52 (s, 1H), 7.23 (t, J=7.9 Hz, 1H), 7.04 (d, J=7.8 Hz, 1H), 7.01 (s, 1H), 6.85 (d. J=7.8 Hz, 1H), 5.97 (s, 1H), 3.95 (dd, J=62, 4.6 Hz, 4H), 3.90 (s, 3H), 1.84-1.75 (m, 1H), 1.25 (s, 9H), 0.93 (q. J=5.3 Hz, 2H), 0.71 (q, J=5.3 Hz, 2H).
[0618] According to procedure (B), tert-butyl 2-(3-{[2-cyclopropyl-6-fluoro-4-(methoxycarbonyl)phenyl]amino}phenyl)-4,5-dihydro-1H-imidazole-1-carboxylate (320 mg, 0.70 mmole, 1 eq.) was placed in a mixture of THF (4.2 mL), methanol (0.8 mL) and water (0.8 mL), and LiOH.H.sub.2O (148 mg, 3.53 mmoles, 5 eq.) was added. The reaction mixture was stirred for 16 hours at room temperature. It was then concentrated under reduced pressure and, after addition of an aqueous solution of 6M HCl (5 eq.), the aqueous phase was extracted with dichloromethane. The combined organic phases were washed with a saturated aqueous solution of brine, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give 4-[(3-{1-[(tert-butoxy)carbonyl]-4,5-dihydro-1H-imidazol-2-yl}phenyl)amino]-3-cyclopropyl-5-fluorobenzoic acid (294 mg, 95%).
[0619] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.54 (d, J=6.9 Hz, 2H), 7.28 (t, J=7.8 Hz, 1H), 7.04 (d, J=8.0 Hz, 2H), 6.99 (d, J=7.8 Hz, 1H), 6.01 (s, 1H), 4.04 (s, 4H), 1.84-1.79 (m, 1H), 1.29 (s, 9H), 0.93 (q. J=5.3 Hz, 2H), 0.72 (q, J=5.3 Hz, 2H).
[0620] According to procedure (C), a reaction mixture of 4-[(3-{1-[(tert-butoxy)carbonyl]-4,5-dihydro-1H-imidazol-2-yl}phenyl)amino]-3-cyclopropyl-5-fluorobenzoic acid (250 mg, 0.57 mmole, 1 eq.) and CDI (111 mg, 0.68 mmole, 1.2 eq.) in anhydrous DMF (2.9 mL) was stirred at room temperature for 5 hours. The mixture was then added to a solution of 4,5-dihydro-1H-imidazol-2-amine (73 mg, 0.85 mmole, 1.5 eq.) and DIPEA (470 μL, 2.84 mmoles, 5 eq.) in anhydrous DMI (2.9 mL) and the resulting mixture was heated at 60° C. and stirred for 16 hours. The reaction mixture was then cooled down to room temperature and concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel to give tert-butyl-2-[3-({2-cyclopropyl-6-fluoro-4-[(imidazolidin-2-ylidene)carbamoyl]phenyl}amino)phenyl]-4,5-dihydro-1H-imidazole-1-carboxylate (127 mg, 44%).
[0621] .sup.1H NMR (300 MHz, CDCl.sub.3) δ 7.72 (dd, J=11.2, 1.6 Hz, 1H), 7.66 (br s, 1H), 7.60 (s, 1H), 7.19 (t, J=7.8 Hz, 1H), 6.98 (d, J=7.8 Hz, 1H), 6.95 (s, 1H), 6.80 (d, J=7.8 Hz, 1H), 5.83 (s, 1H), 3.93 (dd, J=6.6, 4.8 Hz, 4H), 3.67 (s, 4H), 1.88-1.76 (m, 1H), 1.23 (s, 9H), 0.89 (q, J=5.3 Hz, 2H), 0.74 (q, J=5.3 Hz, 2H).
[0622] To a solution of tert-butyl-2-[3-({2-cyclopropyl-6-fluoro-4-[(imidazolidin-2-ylidene)carbamoyl]phenyl}amino)phenyl]-4,5-dihydro-1H-imidazole-1-carboxylate (100 mg, 0.20 mmole, 1 eq.) in anhydrous DCM (600 μL) was added a 4N HCl solution in dioxane (250 μL, 0.99 mmole, 5 eq.) and the reaction mixture was stirred at room temperature for 6 hours. After filtering the resulting precipitate and washing it with dichloromethane, 20 mg were loaded onto a SCX cartridge, eluting with MeOH and then with a 2N ammonia solution in MeOH to afford 3-cyclopropyl-4-{[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]amino}-5-fluoro-N-(imidazolidin-2-ylidene)benzamide (169) (15 mg, 59% extrapolated).
[0623] .sup.1H NMR (300 MHz, d.sub.6-DMSO) δ 8.16 (s, 2H), 7.84 (s, 1H), 7.61 (d, J=11.5 Hz, 1H), 7.48 (s, 1H), 7.22-7.08 (m, 3H), 6.75 (d, J=7.7 Hz, 1H), 3.53 (s, 4H), 3.33 (s, 4H), 2.04-1.94 (m, 1H), 0.90 (q, J=5.3 Hz, 2H), 0.60 (q. J=5.3 Hz, 2H).
[0624] .sup.13C NMR (75 MHz, d.sub.6-DMSO) δ 173.8, 165.3, 164.2, 156.6 (d, J=242.4 Hz), 145.6, 140.3, 135.6 (d, J=6.8 Hz), 131.3, 130.5 (d, J=12.8 Hz), 128.5, 120.6, 117.0, 116.2, 113.1 (d, J=21.0 Hz), 112.8, 41.3, 11.3, 8.8
[0625] [M+H].sup.+=407.3
[0626] Pharmacological Data
Example 14: RSV Virus
[0627] The compounds of the invention have been the subject of pharmacological tests which have demonstrated their relevance as active substances in therapy and in particular for preventing, inhibiting or treating RSV virus infection.
[0628] Material and Methods
[0629] Protocol for Screening Antiviral Compounds for RSV Inhibition and Cytotoxicity using Viral ToxGlo Assay
[0630] HEp-2 cells were maintained in Eagle's minimum essential medium (EMEM) with Earle's BSS adjusted to contain 2 mM L-glutamine, 10% fetal bovine serum, 100 U/ml penicillin and 100 μg/ml streptomycin. For the purposes of the screening assay they were grown to 90% confluency, trypsinized and recovered. The trypsin was neutralised with cell culture media and cells were centrifuged at 150×g for 5 minutes before discarding the supernatant and resuspending cell pellet in assay media (EMEM with Earle's BSS adjusted to contain 2 mM L-glutamine, 2% fetal bovine serum and 100 U/ml penicillin and 100 μg/ml streptomycin). The cells were seeded into white clear-bottomed cell culture plates at a density of 1.5×10.sup.4 cells/well in 50 μl and 4×10.sup.3 cells/well in 25 μl for 96 well plates and 384 well plates respectively. For the media/background control column assay media only was added. Cell plates were placed in a humid chamber and incubated overnight at 37° C./5% CO.sub.2. After overnight incubation cells were checked for confluency and healthy appearance.
[0631] Test articles were made up at 10× test concentration in a maximum DMSO concentration of 10% (final assay concentration maximal 1% DMSO) and added to the cell plates in volumes of 10 μl for 96 well plates and 5 μl for 384 well plates. For cell control and virus control wells the test article solvent only was added. Virus or assay media for cytotoxicity test wells and media/cell control wells was added immediately after test articles at an MOI of 0.5, 40 or 20 μl for 96 and 384 well plates respectively. Virus suspension was prepared by thawing RSV A2 frozen stocks and diluting to the required concentration of plaque forming units in assay media on ice.
[0632] Cell plates were further incubated inside a humid chamber for 72 h p.i at 37° C./5% CO.sub.2. After the incubation period cells were observed under the microscope to check for characteristic cytopathic effect in virus control wells and healthy cells in the cell control wells. After plates were adjusted to room temperature 20/40 μl Viral ToxGlo (Promega) was added to each well of the 384/96 well cell plates. Plates were incubated at room temperature, protected from light on a plate rocker for 20 minutes before measuring the luminescence on a spectrophotometer (Biotek Synergy HTX).
[0633] RSV inhibition was calculated as percentage of cytopathic effect inhibition relative to the virus control and cytotoxicity as percentage of cell survival relative to cell control wells. This allowed EC.sub.50 values to be calculated for each test article where a virus inhibition or cytotoxic dose response was identified. EC.sub.50 values ranging between 0.001 μM and 2.5 μM were found, and more particularly for compounds 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 69, 70, 71, 72, 73, 74, 91, 92, 94, 95, 96, 97, 98, 99, 100, 102, 103, 104, 105, 106, 107, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 125, 127, 128, 129, 130, 131, 132, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 163, 164 and 167.
TABLE-US-00003 TABLE III Ex EC.sub.50 (nM) 1 1.6 2 1.9 3 2.2 4 5.7 5 6.1 6 6.5 7 7.0 8 10.3 9 10.8 10 11.5 11 11.8 12 12.2 13 13.6 14 14.4 15 14.9 16 15.6 17 19.8 18 21.2 19 22.8 20 23.5 21 25.8 22 26.0 23 30.3 24 31.7 25 32.2 26 34.4 27 41.4 28 42.1 29 42.3 30 42.7 31 47.7 32 49.2 33 50.2 34 50.4 35 51.6 36 55.4 37 55.5 38 63.7 39 66.2 40 69.2 41 77.2 42 78.4 43 79.8 44 90.4 45 91.5 46 103.9 47 113.4 48 117.1 49 118.1 50 135.7 51 140.4 52 141.8 53 152.8 54 165.9 55 168.3 56 174.0 57 199.7 58 206.6 59 237.1 60 241.1 61 515.9 62 640.9 63 726.9 64 950.4 69 1134 70 1148 71 1170 72 1227 73 1288 74 1307 91 2.0 92 276.7 94 240.0 95 95.9 96 839.4 97 51.0 98 228.4 99 35.3 100 458.3 102 819.4 103 19.4 104 12.4 105 3.2 106 5.7 107 14.0 109 45.0 110 323.8 111 30.4 112 709.7 113 59.9 114 32.6 115 29.6 116 130.6 117 5.6 118 27.0 119 108.3 120 19.5 121 5.1 122 7.8 123 83.0 125 19.1 127 100.8 128 13.2 129 4.3 130 7.3 131 77.9 132 23.6 134 39.2 135 28.7 136 32.0 137 204.5 138 233.2 139 151.9 140 227.1 141 150.5 142 41.4 143 59.7 144 48.1 145 474.6 146 252.7 147 99.4 148 346.7 149 45.8 150 262.6 152 1136.6 153 31.6 154 69.8 155 51.8 156 40.7 157 26.6 158 6.8 159 225.2 160 544.7 161 690.2 163 35.0 164 3.8 167 17.8
[0634] Conclusion
[0635] Based on the previous results, it can be concluded that the compounds of foi nula (I) are suitable chemical compounds for treating and/or preventing RNA virus infections caused by RNA viruses of group V, more particularly, pneumovirus infections, and most particularly RSV virus infections.
[0636] The present invention further relates to a pharmaceutical composition comprising at least one new compound as defined above or any of its pharmaceutically acceptable salts, or at least any of compounds (1) to (181) as defined above or any of its pharmaceutically acceptable salts and also at least one phaimaceutically acceptable excipient.
[0637] Pharmaceutical compositions of the invention can contain one or more compound(s) of the invention in any form described herein. Still a further object of the present invention consists of the use of at least one compound of formula (I), as defined above, and compounds (1) to (181) as defined above, or one of their pharmaceutically acceptable salts according to the present invention for preparing a drug to prevent or treat, in a subject, a RNA virus infection caused by a RNA virus from group V according to the Baltimore classification, and for example a RSV infection.
[0638] Therefore, the present invention relates to one compound of formula (I), as defined above, and compounds (1) to (181) or one of their acceptable salts as an agent for inhibiting, preventing or treating a RNA virus infection, and most preferably a RNA virus infection from group V, and for example a RSV infection.
[0639] According to a particular embodiment, the treatment is continuous or non-continuous.
[0640] A “continuous treatment” means a long-term treatment which can be implemented with various administration frequencies, such as once every day, every three days, once a week, or once every two weeks or once every month.
[0641] According to one embodiment, the compound of formula (I), or anyone of its pharmaceutically acceptable salts, is administered at a dose varying from 0.1 to 1000 mg, in particular varying from 0.1 to 10 mg, or for example varying from 10 to 200 mg, or for example varying from 200 to 1000 mg.
[0642] Another object of the invention relates to a therapeutic method for treating and/or preventing a subject from a RNA virus infection, and most preferably a RNA virus infection caused by a virus belonging to group V of the Baltimore classification comprising the administration of a therapeutically effective quantity of a compound of formula (I), compounds (1) to (181), as defined above, or one of their acceptable salts.
[0643] In a specific embodiment, the invention provides a use of a compound of formula (I) according to the invention or a pharmaceutically acceptable salt thereof or a pharmaceutically active derivative thereof or a method according to the invention wherein the compound of formula (I) is to be administered in combination with a co-agent useful in the treatment of said RNA virus infection, and most preferably said RNA virus infection from group V, and for example RSV infection.
[0644] The compounds can be administered through any mode of administration such as, for example, intramuscular, intravenous, intranasal or oral route, etc.
[0645] Compounds of the present invention may, in appropriate cases, be administered as prodrugs, such as esters, of compounds with which the invention is concerned. “Prodrug” means a compound which is convertible in vivo by metabolic means (e.g. by hydrolysis, reduction or oxidation) to a compound of the present invention. For example, an ester prodrug of a compound of the present invention may be convertible by hydrolysis in vivo to the parent molecule. Suitable esters of compounds of the present invention are for example acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-13-hydroxynaphthoates, gentisates, isethionates, di-p-toluoyltartrates, methanesulphonates, ethanesulphonates, benzenesulphonates, p-toluenesulphonates, cyclohexylsulfamates and quinates. Examples of ester prodrugs are those described by F. J. Leinweber, Drug Metab. Res., 1987, 18, 379. As used herein, references to the compounds of the present invention are meant to also include any prodrug or metabolite forms.
[0646] The inventive composition can further include one or more additives such as diluents, excipients, stabilizers and preservatives. Such additives are well known to those skilled in the art and are described notably in “Ullmann's Encyclopedia of Industrial Chemistry, 6.sup.th Ed.” (various editors, 1989-1998, Marcel Dekker) and in “Pharmaceutical Dosage Forms and Drug Delivery Systems” (ANSEL et al., 1994, WILLIAMS & WILKINS).
[0647] The aforementioned excipients are selected according to the dosage form and the desired mode of administration.
[0648] According to another embodiment, pharmaceutically acceptable compositions of this invention can be administered to humans and other animals orally, rectally, parenterally, intracisternally, intravaginally, intraperitoneally, topically (as by powders, ointments, or drops), bucally, as an oral or nasal spray, or the like, depending on the severity of the infection being treated.
[0649] Compositions of the present invention may be administered orally, parenterally, by inhalation spray, topically, rectally, nasally, buccally, vaginally or via an implanted reservoir. The term “parenteral” as used herein includes subcutaneous, intravenous, intramuscular, intra-articular, intra-synovial, intrasternal, intrathecal, intrahepatic, intralesional and intracranial injection or infusion techniques. Preferably, the compositions are administered orally, intraperitoneally or intravenously. Sterile injectable forms of the compositions of this invention may be aqueous or oleaginous suspension. These suspensions may be formulated according to techniques known in the art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium.
[0650] Compositions of this invention may be administered in any manner, including, but not limited to, orally, parenterally, sublingually, transdermally, vaginally, rectally, transmucosally, topically, intranasally via inhalation, via buccal or intranasal administration, or combinations thereof. Parenteral administration includes, but is not limited to, intravenous, intra-arterial, intra-peritoneal, subcutaneous, intramuscular, intra-thecal, and intra-articular. The compositions of this invention may also be administered in the form of an implant, which allows slow release of the compositions as well as a slow controlled i.v. infusion.
[0651] For example, a compound of formula (I) can be present in any pharmaceutical form which is suitable for enteral or parenteral administration, in association with appropriate excipients, for example in the form of plain or coated tablets, hard gelatine, soft shell capsules and other capsules, suppositories, or drinkable, such as suspensions, syrups, or injectable solutions or suspensions, in doses which enable the daily administration of from 0.1 to 1000 mg of active substance.
[0652] In a particular embodiment, a compound of formula (I) according to the invention is administered orally.
[0653] Oral route of administration is in particular preferred in the prophylaxis or treatment aspect of the invention.