Glass-ceramic composite material

Abstract

The present invention relates to a glass-ceramic composite material, which is a composite material with degradability and osteoconductivity, and is composed of CaOMgOSiO.sub.2 (CMS glass)+CaMgSi.sub.2O.sub.6 (CMS ceramic) and CaSO.sub.4 (CS ceramic). In addition to the CaOMgOSiO.sub.2 glass, this synthesized composite material mainly includes two ceramics of CaMgSi.sub.2O.sub.6 and CaSO.sub.4 in crystalline phase, wherein, both the CMS glass and CMS ceramic have high mechanical strength, biocompatibility and osteoconductivity, while CaSO.sub.4 has the characteristics of rapid degradation to promote bone ingrowth.

Claims

1. A glass-ceramic composite material, comprising: (CaOMgOSiO.sub.2+CaMgSi.sub.2O.sub.6).sub.x(CaSO.sub.4).sub.y, wherein CaOMgOSiO.sub.2 is in glass phase, the CaMgSi.sub.2O.sub.6 is in crystalline phase, the CaSO.sub.4 is in crystalline phase, x and y are weight ratios and x:y is 2:1, 1:1 or 1:2.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is the characteristic experimental data diagram of the glass-ceramic composite material according to the present invention;

(2) FIG. 2 is the characteristic experimental data diagram of the glass-ceramic composite material according to the present invention;

(3) FIG. 3 is the characteristic experimental data diagram of the glass-ceramic composite material according to the present invention;

(4) FIG. 4 is the characteristic experimental data diagram of the glass-ceramic composite material according to the present invention;

(5) FIG. 5 is the characteristic experimental data diagram of the glass-ceramic composite material according to the present invention; and

(6) FIG. 6 is the characteristic experimental data diagram of the glass-ceramic composite material according to the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

(7) The glass-ceramic composite material of the present invention is composed of CaOMgOSiO.sub.2 glass+CaMgSi.sub.2O.sub.6 ceramic and CaSO.sub.4 ceramic, and is applied to living organisms and/or biological materials. It can be found from the experiments that the advantage of the CS material, which is conventionally used in artificial bone materials, is rapid degradation to promote bone ingrowth, while the advantages of CMS in the glass-ceramic composite material of the present invention are high mechanical strength, high biocompatibility and high osteoconductivity, the present invention combines these two materials to form a glass-ceramic composite material.

(8) The glass-ceramic composite material with degradability and osteoconductivity of the present invention mainly comprises CMS (CaOMgOSiO.sub.2 in glass phase+CaMgSi.sub.2O.sub.6 in crystalline phase) and CS (CaSO.sub.4 in crystalline phase), wherein the CaMgSi.sub.2O.sub.6 in crystalline phase has high mechanical strength, biocompatibility and osteoconductivity, while the CaSO.sub.4 in crystalline phase has the characteristics of rapid degradation to promote bone ingrowth.

(9) Specifically, the ratios and steps of the synthesis process of the CaOMgOSiO.sub.2 glass include: powder formulation, raw powder mixing, glass melting and powder fine grinding.

(10) Specifically, the powder formulation step is conducted under a ratio of CaCO.sub.3:Mg(OH).sub.2:SiO.sub.2 (25:25:50 mol %)+8.5 wt % ZrO.sub.2 (glass-ceramic nucleating agent).

(11) In the raw powder mixing step, powder:ball:water (20:60:20 wt %) are mixed at 180 rpm for 20 minutes, sieved with a sieve, and dried in an oven at 170 C.

(12) In the glass melting step, the temperature is set at 1500 C. and maintained for 2 hours, and then the glass is quenched with water.

(13) In the powder fine grinding step, powder:ball:water are mixed at a ratio (13:79:8 wt %) and fine-ground to about 1 m with a grinding machine at 30 g/20 min, then sieved with a sieve, and the powder is dried in an oven at 170 C. to complete the production of the CaOMgOSiO.sub.2 bioglass.

(14) Next, the composite material of the present invention is used to synthesize porous scaffolds, and the ratios and steps thereof are as follows: firstly, slurries of CaOMgOSiO.sub.2 glass and CaSO.sub.4.Math.2H.sub.2O ceramic are prepared, in which the powders are formulated according to five weight ratios of CMS:CS2H=3:0, 2:1, 1:1, 1:2, 0:3, and the slurries are formulated with a ratio of powder:water:binder=(50:31.25:18.75 wt %), and stirred-mixed by a rotor (500 rpm, 5 min); then a PU sponge is soaked in the above slurries of different ratios, in which the sponge is cut into 1.5 cm.sup.3 with a hot melt wire, soaked with the slurries, and dried in an oven at 170 C.; finally, the sponges soaked with the slurries of different weight ratios (CMS:CS2H=3:0, 2:1, 1:1, 1:2) are sintered at 900 C. for 2 hours, while the sponge soaked with the slurry (the weight ratio of CMS:CS2H=0:3) is sintered at 1100 C. for 1 hour, thereby the synthesis of porous scaffolds of the composite material of the present invention is completed.

(15) Specifically, the characteristics and data in the experiments for the composite material of the present invention are shown in FIGS. 1-6.

(16) Regarding the porosity of the composite materials, it can be seen from FIG. 1 that, in the cases that the weight ratios of CMS:CS2H are 3:0, 2:1, 1:1, 1:2 and 0:3, respectively, except for the composite material containing only CMS, the porosity of each of the composite materials of the other ratios is greater than 70%, which meet the standard.

(17) Regarding the mechanical strength of the composite materials, it can be seen from FIG. 2 that, in the cases that the weight ratios of CMS:CS2H are 3:0 and 2:1, respectively, the composite materials have better mechanical strength.

(18) Regarding the pH value of the composite materials after degradation, a pH value between 7 and 8 is the most suitable for cell growth in terms of common sense or convention. Therefore, it can be seen from FIG. 3 that, in the cases that in the weight ratios of CMS:CS2H are 3:0, 2:1, 1:1, 1:2 and 0:3, respectively, after being soaked in a Tris-HCl solution for 120 hours, the pH value of each of the composite materials after degradation is between 7 and 8.

(19) Regarding the measurement of weight loss of the composite material after degradation, if the weight lost due to the degradation is more, it means that more ions are released to help the growth of bone cells, and the effect is better. It can be seen from FIG. 4 that, in the cases that the weight ratios of CMS:CS2H are 3:0, 2:1, 1:1, 1:2 and 0:3, respectively, the composite materials of the present invention obviously has a greater weight loss under the condition of containing CS2H, that is, they has faster degradation rates, which can promote the early growth of bone cells into the bone material.

(20) Regarding the experiments for the concentration of the ions released due to the degradation of the composite materials, it can be seen from FIGS. 5 and 6 that, in the cases that the weight ratios of CMS:CS2H are 3:0, 2:1, 1:1, 1:2 and 0:3, respectively, the composite materials will develop into (CaOMgOSiO.sub.2+CaMgSi.sub.2O.sub.6).sub.x(CaSO.sub.4).sub.y, which is abbreviated to CMS.sub.cCS.sub.y, and Ca, Mg, Si, and S ions are obtained after the degradation of CMS.sub.cCS.sub.y. It can be seen from FIG. 5 that in an extreme solution (citric acid solution), the CMS glass-ceramic has lower degradability, while the composite materials of CMS glass-ceramic containing CS calcium sulfate have higher degradability. It can be seen from FIG. 6 that in Tris-HCl simulated body fluid, the concentration of the ions released due to the degradation of CMS glass-ceramic is lower, so the composite materials containing CS calcium sulfate have higher degradability.

(21) Specifically, the preferred weight ratio of CMS to CS in the glass-ceramic composite material is between 3:0 and 1:2.

(22) Finally, the technical features of the present invention and their achievable technical effects are summarized as follows:

(23) First, the biocompatibility is improved by the glass-ceramic composite material of the present invention.

(24) Second, the glass-ceramic composite material according to the present invention degrades rapidly to promote bone ingrowth.

(25) Third, the glass-ceramic composite material according to the present invention has high mechanical strength and high osteoconductivity.

(26) The embodiments of the present invention are described above by means of specific embodiments, those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

(27) The above descriptions are only preferred embodiments of the present invention, but not intended to limit the scope of the present invention; all other equivalent changes or modifications made without departing from the spirit disclosed in the present invention shall be included in the scope of the appended claims.