Endogenous tumor-derived circular RNA and proteins thereof for use as vaccine

Abstract

The present invention relates to an endogenous tumor-derived circular ribonucleic acid (circ RNA) as well as one or more proteins expressed from said tumor-derived circ RNA. The invention further relates said tumor-derived circ RNA and the protein(s) expressed thereof for use vaccines in the prophylaxis and/or treatment of cancer.

Claims

1. A pharmaceutical composition comprising endogenous tumor circRNA, and a pharmaceutically acceptable excipient comprising a preservative, an adjuvant, a stabilizer, a buffer, or any combination thereof, formulated as a vaccine effective in the treatment of cancer, wherein the circRNA is the total circRNA content from the tumor cells.

2. A pharmaceutical composition comprising protein derived from endogenous tumor circRNA, and a pharmaceutically acceptable excipient comprising a preservative, an adjuvant, a stabilizer, a buffer, or any combination thereof, formulated as a therapeutic vaccine effective in the treatment of cancer, wherein the circRNA from which the protein is derived is the total circRNA content from the tumor cells.

3. A method of preparing an endogenous tumor circRNA to be formulated as a vaccine in the treatment of cancer, wherein the method comprises the steps of: a. extracting total RNA content from tumor cells; b. enriching circRNA by enzyme digestion of linear RNA, wherein the enriched circRNA is the total circRNA content from the tumor cells, and c. mixing the enriched circRNA with at least one pharmaceutically acceptable excipient comprising a preservative, an adjuvant, a stabilizer, a buffer, or any combination thereof.

4. A method of preparing an endogenous tumor circRNA vaccine, comprising the steps of: a. extracting total RNA content from tumor cells of a patient; b. enriching circRNA from the extracted total RNA by enzyme digestion of linear RNA, wherein the enriched circRNA is the total circRNA content from the tumor cells; and c. mixing the enriched circRNA with at least one pharmaceutically acceptable excipient suitable for the vaccine.

5. A method of preparing a protein derived from endogenous tumor circRNA for use as a vaccine, comprising the steps of: a. extracting total RNA content from tumor cells of a patient; b. enriching circRNA from the extracted total RNA by enzyme digestion of linear RNA, wherein the enriched circRNA is the total circRNA content from the tumor cells; c. identifying neoantigen protein expressed by the enriched circRNA; and d. detecting personalized/general potential of the protein as immunogen.

6. A method of preparing an endogenous tumor circRNA, comprising: a. extracting total RNA content from tumor cells of a patient; b. enriching circRNA from the extracted total RNA by enzyme digestion of linear RNA, wherein the enriched circRNA is the total circRNA content from the tumor cells; and c. returning the enriched circRNA to antigen presenting cells ex vivo; wherein the antigen presenting cells generate an immune response.

7. A personalized method of treating a prostate cancer patient comprising: a. extracting total RNA content from tumor cells of a patient; b. enriching circRNA from the extracted total RNA by enzyme digestion of linear RNA, wherein the enriched circRNA is the total circRNA content from the tumor cells; c. mixing the enriched circRNA with at least one pharmaceutically acceptable excipient to form a mixture; and d. administering an effective amount of the mixture to the patient.

8. A method of treating a prostate cancer patient comprising: a. extracting total RNA content from tumor cells of a patient; b. enriching circRNA from the extracted total RNA by enzyme digestion of linear RNA, wherein the enriched circRNA is the total circRNA content from the tumor cells; c. identifying an immunogenic potential of neoantigen protein from the circRNA; and d. administering an effective amount of the neoantigen protein to the patient.

9. The pharmaceutical composition according to claim 1, wherein the cancer is prostate cancer, breast cancer, colon cancer, lung cancer and/or pancreatic cancer.

10. The pharmaceutical composition according to claim 2, wherein the cancer is prostate cancer, breast cancer, colon cancer, lung cancer and/or pancreatic cancer.

11. The pharmaceutical composition according to claim 1, wherein the cancer is prostate cancer.

12. The pharmaceutical composition according to claim 2, wherein the cancer is prostate cancer.

13. The pharmaceutical composition according to claim 1, wherein the pharmaceutically acceptable comprises an adjuvant comprising an aluminum salt or an oil-based compound, or a stabilizer comprising a sugar, amino acid, human serum albumin or gelatin, or any combination thereof.

14. The pharmaceutical composition according to claim 2, wherein the pharmaceutically acceptable comprises an adjuvant comprising an aluminum salt or an oil-based compound, or a stabilizer comprising a sugar, amino acid, human serum albumin or gelatin, or any combination thereof.

15. The pharmaceutical composition according to claim 1, wherein the endogenous tumor circRNA is prepared by a method comprising: a. extracting total RNA content from tumor cells of a patient; and b. enriching circRNA from the extracted total RNA by enzyme digestion of linear RNA.

Description

BRIEF DESCRIPTION OF FIGURES

(1) FIG. 1A illustrates RNA splicing and FIG. 1B illustrates circRNA splicing.

(2) FIG. 2 illustrates the translation of circRNA into proteins.

(3) FIG. 3 illustrates the process for manufacturing circRNA-based vaccines.

(4) FIG. 4 illustrates the process for manufacturing vaccines comprising proteins derived from circRNA.

(5) FIGS. 5 and 6 show experimental results from circRNA vaccination of rats. There is increased proliferation of CD8+ T cells in vaccinated rats compared to a control rat group.

(6) FIG. 7 show experimental results from circRNA vaccination of rats. There is no difference in proliferation of CD4+ T cells between vaccinated rats and a control rat group.

(7) FIG. 8 show experimental results from circRNA vaccination of rats. In vaccinated rats there is an increased tumor necrosis.

(8) FIGS. 9a-9c show experimental results from circRNA vaccination of mice. There is increased proliferation of CD4+ T cells and B cells in vaccinated mice compared to a control mice group, FIG. 9a and FIG. 9c, respectively. There is a minimal effect on proliferation of CD8+ T-cells, FIG. 9b.

DETAILED DESCRIPTION

(9) Splicing is the editing of the nascent precursor messenger RNA (pre-mRNA) transcript into a mature mRNA. As illustrated in FIG. 1A, after splicing (i.e. normal RNA splicing), introns are removed and exons are joined together (ligated). The splicing of the tumor-derived circRNA of the present invention differs from normal RNA splicing in that, during the formation of the circular RNA, the back-splicing process will introduce a unique fusion of two RNA nucleotides stretches as illustrated in FIG. 1B.

(10) The tumor-derived circRNA of the present invention can be translated into proteins by at least the three types of processes as illustrated in FIG. 2. Both the circRNA and the resulting proteins can be used for use in the prophylaxis and treatment of cancer.

(11) In the Type-I process illustrated in FIG. 2A, the ORF is out of frame and the RNA is translated into a (neo-antigen) protein from an alternative read frame compared to the normal gene product.

(12) The type-II process which is illustrated in FIG. 2B differs from the Type-I process in that, the Type-II process the translation of the (neo-antigen) protein cross a back-splicing site (BSS), and therefore, in the type-II process novel (neo-antigen) proteins can be produced by out-of-frame (from the normal gene product) translation of the ORF both before and/or after the BSS. In the type-II process the fusion site at the BSS can as well generate neo-antigen peptides.

(13) The type III process which is illustrated in FIG. 2C involves a rolling circle amplified protein. The circRNA has an ORF that only contains a start codon (AUG) and produce a peptide that is in-frame with itself after passing the start codon and protein can continue to be translated in a rolling circle amplification manner. This leads to a rolling circle amplification of the generated peptide and potentiate the neo-antigen production, which leads to an enhanced immune response to the antigen.

(14) Delivering RNA to subjects and induction of an adaptive immune response against said RNA is known in the art. This approach has previously been used in eliciting an immune response to RNA. Hence, full-length mRNAs or short oligonucleotide repeats against mutated regions have been selected and amplified in prior art techniques.

(15) The present invention differs from prior art techniques in that tumor tissue is used and total RNA is extracted from the tumor cells. Within the total pool of tumor derived RNA molecules there is a fraction that consist of circularized RNA molecules (due to back-splicing events). The tumor-derived circRNA pool contains tumor specific circRNA with unique open-reading frames (ORFs) not normally expressed. ORFs that can be translated into peptides as novel proteins and hence be presented as novel neo-antigens that can stimulate immune responses toward the neo-antigens.

(16) The strength of the present invention is that it is totally new protein sequence that compose the epitopes that are inducing the immune response, compared to mutations that only change a single or a few amino acids or full proteins over expressed in cancer that already have had a negative selection against their epitopes. Another aspect is that circRNAs are very diverse in their composition and that cancer induced changes have big impact on the repertoire of expressed circRNAs, thus a wide range of neo-antigens can be present at the same time within a tumor. Moreover, circRNAs are nuclease resistant by their circular structure and much more resistant against degradation than linear RNA molecules once injected in the patient enhancing the delivering potential.

(17) The circRNA extracted from the patient will contain the multiplicity of unique tumor-derived circRNAs that have the potential to via antigen presenting cells present novel neo-antigens for the immune system.

(18) In the present invention, tumor-derived circRNA from the patient will be prepared and divided into vaccination batches and booster batches, and administered either by injection in-vivo at sites of immune presentation (like adjacent to lymph nodes, within lymph nodes) or ex-vivo for immune cell stimulation and cell based therapy.

(19) In the present invention, tumor-derived circRNA are isolated and sequenced from subjects (i.e. patients) with well-defined tumor types. The invention is not limited to a certain cancer type and is therefore applicable for all types of cancer. Subsequently, a database with identified and potential unique open reading frames within circRNA are built that are not present within normal cell transcription within the patients. This will: 1. Allow for the identification of potential neo-antigens within (back-spliced) circRNA that are common for a certain tumor type, and 2. Allow for the identification of potential neo-antigens within (back-spliced) circRNA that are unique for a single patient

(20) Importantly, results from (1) will identify circRNA neo-antigens that are suitable for prophylactic vaccination (i.e. to vaccinate healthy individuals against a particular cancer) and therapeutic vaccination (i.e. patients with corresponding cancer). Results from (2) will identify circRNA neo-antigens that can be rapidly introduced into a delivery vector for personalized therapeutic vaccination against pre-existing tumors in a cancer patient.

(21) The pharmaceutical compositions and vaccines of the present invention may comprise pharmaceutically acceptable excipients used in the art. Preservatives, adjuvants, stabilizers and buffers are examples excipients which may be used but the present invention is not restricted to these examples.

(22) Preservatives are used to prevent growth of bacteria or fungi that may be introduced into the vaccine during its use, for example by repeated puncture of a multi-dose vaccine vial with a needle.

(23) Adjuvants helping stimulate a stronger immune response of vaccinated individuals.

(24) Aluminum salts may be incorporated into a vaccine formulation as an adjuvant. Examples of aluminum salts are aluminum hydroxide, aluminum phosphate, alum (potassium aluminum sulfate), or mixed aluminum salts. Organic compounds such as squalene or oil-based compounds may also be used as adjuvant.

(25) Stabilizers keep vaccines potent during transportation and storage. They help protect the vaccine from adverse conditions such as the freeze-drying process, for those vaccines that are freeze dried. Some examples of stabilizers which may be added to vaccines include: sugars such as sucrose and lactose, amino acids such as glycine or the monosodium salt of glutamic acid and proteins such as human serum albumin or gelatin.

(26) In the present invention, the term protein is defined as a molecule which comprises one or more chains of amino acid residues. The terms peptide, oligopeptide and polypeptide are in the present invention also included in the definition of protein.

(27) In the present invention, the expression tumor-derived circRNA is defined as tumor-isolated circRNA (or alternatively circRNA isolated from tumor).

(28) In the present invention, the expression protein derived from a tumor-derived circRNA is defined as protein encoded by tumor-derived circRNA (or alternatively protein expressed from tumor-derived circRNA.

EXAMPLES

Example 1Tumor-derived circRNA

(29) The method described in Example 1 is briefly illustrated in FIG. 3.

(30) Tumor tissue is harvested from the patient and the total RNA content in the tumor cells are extracted with RNA isolation methodology used in the art. The circular RNA fraction is further enriched by for example enzyme digestion of linear RNA (by for example using RNAse R).

(31) RNA quality control and content may be monitored by a combination of Bioanalyser (Agilent) and Qubit (Thermofisher) measurements or by similar instruments. circRNA is aliquoted and may be stored at 80 C. (or at other suitable temperatures) in different batches (e.g. vaccination and booster) ready to be administered to the patient after reconstituting the frozen batches with physiological buffer (such as Hanks Buffers Saline Solution/NaCl).

(32) The endogenous tumor-derived circRNA prepared according to Example 1 comprises a nucleotide sequence selected from SEQ ID No: 1 to 299 (which are disclosed in Table 1 and the sequence listing) or homologous nucleotide sequences thereof having at least 80% homology. However, the present invention is not restricted to these specific sequences, and therefore, tumor-derived circRNA having other RNA sequences may be used for prophylaxis and/or treatment of disease.

(33) The resulting vaccine is a therapeutic vaccine which is personalized for the patient from whom the tumor tissue has been harvested.

(34) The personalized vaccine described in Example 1 is advantageous since it can be produced in 1-2 days. As a contrast, it takes several months, if not longer, to produce the vaccines described in the prior art.

(35) The usability of the method described has been demonstrated in a pilot experiment where personalized therapeutic vaccination led to an increased immune activation against prostate cancer cells in two animal models (the Dunning Rat prostate cancer model and the TRAMP-C1 prostate cancer mouse model).

Example 2Proteins from Tumor-Derived Circular RNA

(36) The method described in Example 2 is briefly illustrated in FIG. 4.

(37) Tumor tissue is harvested from the patient and the total RNA content in the tumor cells are extracted with RNA isolation methodology used in the art. The circular RNA fraction is further enriched by for example enzyme digestion of linear RNA (by for example using RNAse R).

(38) RNA quality control and content may be monitored by a combination of Bioanalyser (Agilent) and Qubit (Thermofisher) measurements or by similar instruments. circRNA is aliquoted and may be stored at 80 C. (or at other suitable temperatures) in different batches.

(39) The neoantigen proteins which can be expressed by circRNA are identified by using one or more of the following methods: RNA sequencing protein mass-spectrometry In vitro translation Prediction of MHC class I/II-binding

(40) The next step in the method involves the identification of personalized/general potential of the neoantigen protein as immunogen by using one or more of the following methods: In vitro stimulation of T-cells from patients with neo-antigens and detection of specific T cell responses by standard immunological assays, such as immune cell proliferation of cytokine production by Flow cytometry or ELISpot Determination of B cell-responses to neoantigen by standard immunological assays (such as ELISA/ELISpot)

(41) The proteins derived from the tumor-derived circRNA isolated according to the method described in Example 2 comprise a protein sequence selected from SEQ ID No: 300 to 598 (which are disclosed in Table 1 and the sequence listing). However, the present invention is not restricted to these specific sequences, and therefore, proteins derived from tumor-derived circRNA having other protein sequences may be used for prophylaxis and/or treatment of disease.

(42) The proteins can be extracted from tumor cells. Moreover, the proteins can also be prepared by liquid-phase synthesis [11,13], solid-phase synthesis [11,13] or by an expression vector [12,13], or by any other method known in the art.

(43) The proteins can also be synthesized by the patient's cell by genetic vaccination or gene therapy with DNA or RNA vectors coding for neoantigen sequences corresponding to a tumor-derived circRNA sequence.

EXPERIMENTS

(44) Rat Experiment: 1. Total RNA was isolated from MAT-Ly-Lu (Dunning R-3327 prostate cancer animal model) cells. 2. Linear RNA was digested with RNAse R (Epicenter) to enrich for circRNA (1U RNAse R/ug total RNA). The digest total RNA was cleaned-up (Agencourt RNAClean XP), and yielded 12 vaccine doses of 30 ug circRNA per dose. 3. Vaccine was prepared for the four Copenhagen rats: One dose (30 ug) circRNA was mixed with physiological NaCl solution to a volume of 100 ul, and the prepared vaccine was injected intradermal, close to the inguinal lymph nodes in four Copenhagen rats. Resulting in a dose of 80 ug circRNA/kg animal. 4. To four rats in a control group, 100 ul physiological NaCl solution was injected in the same way as in the vaccination group. 5. Time plan: Vaccination took place during three weeks before injecting 10.000 MAT-Ly-Lu cells within prostate. In brief, at day 0 the first dose was administered, and the second and third was injected at day 7 and day 14. At day 21, ten thousand MAT-Ly-Lu cells was injected into the prostate, and at day 35 the animal was sacrificed. 6. Sample collected: Spleen and lymph nodes where collected, as well as prostate tumor and lung. 7. Analysis: Immune activation was measured by labelling splenocytes/lymphocytes with CFSE and exposing them to mitomycin C-treated MAT-Ly-Lu cells for 5 days. Cells were then labelled with anti-CD8 and anti-CD4 and subjected to flow cytometry. Activation and subsequent proliferation of CD4+ and CD8+ T cells were measured as a decrease in CFSE-intensity (the CFSE is diluted in cells upon cell division). The necrotic tumor areas within the tumor was also investigated and measured between the control group and the vaccinated group. 8. Results: The main mediators of tumor induced immune response are the CD8+ T-cells, the so called cytotoxic T-cells. These cells are well-known to mediate tumor cell elimination of cells expressing neoantigen epitopes on their MHC-I complexes. Interestingly there was a more than threefold induction of proliferation in 50% of the animals (2/4) of the CD8+ T-cells after in vitro exposure to MAT-Ly-Lu cells (2:1 spleenocyte/tumor cell ratio), indicative that two rats have acquired an adaptive immune response against the tumor (see FIGS. 5 and 6). In line with an increased CD8+ T-cell activity there was also a trend toward an increased tumor cell death and necrotic area in vaccinated animals (see FIG. 8). There was no difference in induced CD4 activity between vaccinated rats and a control rat group (see FIG. 7). 9. Summary: We could see an increased mobilization of the adaptive immune system toward the tumor cells after administration of a circRNA vaccination program.
Mouse Experiment: 1. Total RNA was isolated from TRAMP-C1 (prostate cancer mouse cell line with C57BL/6 background) cells. 2. Linear RNA was digested with RNAse R (Epicenter) to enrich for circRNA (1U RNAse R/ug total RNA). The digest total RNA was cleaned-up (Agencourt RNAClean XP), and yielded RNA for eight vaccine doses of 10 ug circRNA per dose. 3. Vaccine was prepared for the four C57BL/6 mice: One dose (10 ug) circRNA was prepared as following, 5 ug circRNA was prepared with 5 ug protamine, incubated 30 min RT for complex binding and then another 5 ug of circRNA was added to the tube in a volume of 100 ul in ringers salt solution. The prepared vaccine was injected intradermal, on the flanks close to the groins. Resulting in a dose of 300 ug circRNA/kg animal. 4. To four mice in a control group, 100 ul ringers salt solution containing 5 ug of protamine was injected in the same way as in the vaccination group. 5. Time plan: Animals were vaccinated day 0 and day 14, and then sacrificed on day 21. 6. Sample collected: Spleens where collected. 7. Analysis: Single cell suspension of CFSE-labelled splenocytes were co-incubated with lysate from TRAMP-C1 cells for 4-5 days. Proliferation/activation of B and T cells was measured as reduced CFSE-intensity on B220+ B cells, CD8+ T cells or CD4+ T cells by flow cytometry. 8. Results: The tumor induced immune response were a pronounced effect seen among the CD4+ T-cell (FIG. 9a) and the B-cells (FIG. 9b), with minimal effect on the CD8+ T-cells (FIG. 9c). In this experiment the mice had not been exposed to the tumor cells in question before analysis, contrary to in the rat experiment (discussed above) where the rats had known the tumor cells for two weeks and thereby triggering a potential immune response. 9. Summary: We could see an increased mobilization of the adaptive immune system toward the tumor cells after administration of a circRNA vaccination program.

(45) TABLE-US-00001 TABLE1 SEQ KLK3neo- IDNO antigen cRNA/protein DNAsequence RNAsequence Proteinsequence 1 1/300 TTGCTAGGAAAAGAAATCAGCAGACACAGGTGTA UUGCUAGGAAAAGAAAUCAGCAGACACAG LLGKEISRHRCRPECFLNGVILSSLCPGEY GACCAGAGTGTTTCTTAAATGGTGTAATTTTGTCC GUGUAGACCAGAGUGUUUCUUAAAUGGU WPCLETYHSISLRTQIGWGVCVICGVQR TCTCTGTGTCCTGGGGAATACTGGCCATGCCTGGA GUAAUUUUGUCCUCUCUGUGUCCUGGGG GACATATCACTCAATTTCTCTGAGGACACAGATAG AAUACUGGCCAUGCCUGGAGACAUAUCAC GATGGGGTGTCTGTGTTATTTGTGGGGTACAGAG UCAAUUUCUCUGAGGACACAGAUAGGAUG ATGA GGGUGUCUGUGUUAUUUGUGGGGUACAG AGAUGA 2 2/301 ATGTGCCCTGCCCGAAAGGCCTTCCCTGTACACCA AUGUGCCCUGCCCGAAAGGCCUUCCCUGU MCPARKAFPVHQGGALPEVDQGHHRG AGGTGGTGCATTACCGGAAGTGGATCAAGGACAC ACACCAAGGUGGUGCAUUACCGGAAGUGG QPLSTPINPLL CATCGTGGCCAACCCCTGAGCACCCCTATCAACCC AUCAAGGACACCAUCGUGGCCAACCCCUGA CCTATTGTAG GCACCCCUAUCAACCCCCUAUUGUAG 3 3/302 GTGTCTGTGTTATTTGTGGGGTACAGAGATGAAA GUGUCUGUGUUAUUUGUGGGGUACAGAG VSVLFVGYRDERGVGSTLREWRVTCAGH GAGGGGTGGGATCCACACTGAGAGAGTGGAGAG AUGAAAGAGGGGUGGGAUCCACACUGAGA CP TGACATGTGCTGGACACTGTCCATGA GAGUGGAGAGUGACAUGUGCUGGACACU GUCCAUGA 4 4/303 TTGTCCTTAGGTGTGAGGTCCAGGGTTGCTAGGA UUGUCCUUAGGUGUGAGGUCCAGGGUUG LSLGVRSRVARKRNQQTQV AAAGAAATCAGCAGACACAGGTGTAG CUAGGAAAAGAAAUCAGCAGACACAGGUG UAG 5 5/304 GTGTTTCTTAAATGGTGTAATTTTGTCCTCTCTGTG GUGUUUCUUAAAUGGUGUAAUUUUGUCC VFLKWCNFVLSVSWGILAMPGDISLNFS TCCTGGGGAATACTGGCCATGCCTGGAGACATAT UCUCUGUGUCCUGGGGAAUACUGGCCAUG EDTDRMGCLCYLWGTEMKEGWDPH CACTCAATTTCTCTGAGGACACAGATAGGATGGG CCUGGAGACAUAUCACUCAAUUUCUCUGA GTGTCTGTGTTATTTGTGGGGTACAGAGATGAAA GGACACAGAUAGGAUGGGGUGUCUGUGU GAGGGGTGGGATCCACACTGA UAUUUGUGGGGUACAGAGAUGAAAGAGG GGUGGGAUCCACACUGA 6 6/305 GTGCTGGACACTGTCCATGAAGCACTGAGCAGAA GUGCUGGACACUGUCCAUGAAGCACUGAG VLDTVHEALSRSWRHNAPDTHSKDGAE GCTGGAGGCACAACGCACCAGACACTCACAGCAA CAGAAGCUGGAGGCACAACGCACCAGACAC NITHSVLEALGSLEKAVSQGGRVFLWHG GGATGGAGCTGAAAACATAACCCACTCTGTCCTG UCACAGCAAGGAUGGAGCUGAAAACAUAA MGMK GAGGCACTGGGAAGCCTAGAGAAGGCTGTGAGC CCCACUCUGUCCUGGAGGCACUGGGAAGC CAAGGAGGGAGGGTCTTCCTTTGGCATGGGATGG CUAGAGAAGGCUGUGAGCCAAGGAGGGAG GGATGAAGTAA GGUCUUCCUUUGGCAUGGGAUGGGGAUG AAGUAA 7(BSS) 7/306 TTGAGCCCCAAGCTTACCACCTGCACCCGGAGAGC UUGAGCCCCAAGCUUACCACCUGCACCCGG LSPKLTTCTRRAVSPCGSRLSSSPCP TGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCAC AGAGCUGUGUCACCAUGUGGGUCCCGGUU CCTGTCCGTGA GUCUUCCUCACCCUGUCCGUGA 8(BSS) 8/307 GTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGA GUGCUGCACCCCUCAUCCUGUCUCGGAUU VLHPSSCLGLWEAGSARSIPNPGRCLWP GGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGC GUGGGAGGCUGGGAGUGCGAGAAGCAUU LVAGQSAAVFWCTPSGSSQLPTASGSAA AGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTG CCCAACCCUGGCAGGUGCUUGUGGCCUCU PLILSRIVGGWECEKHSQPWQVLVASRG CGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTC CGUGGCAGGGCAGUCUGCGGCGGUGUUC RAVCGGVLVHPQWVLTAAHCIR ACAGCTGCCCACTGCATCAGGAAGTGCTGCACCCC UGGUGCACCCCCAGUGGGUCCUCACAGCU TCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTG GCCCACUGCAUCAGGAAGUGCUGCACCCCU CGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTG CAUCCUGUCUCGGAUUGUGGGAGGCUGG GCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTC GAGUGCGAGAAGCAUUCCCAACCCUGGCA TGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCAC GGUGCUUGUGGCCUCUCGUGGCAGGGCA TGCATCAGG GUCUGCGGCGGUGUUCUGGUGCACCCCCA GUGGGUCCUCACAGCUGCCCACUGCAUCA GG 9(BSS) 9/308 CTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAG CUGGGAGUGCGAGAAGCAUUCCCAACCCU LGVREAFPTLAGACGLSWQGSLRRCSGA GTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCG GGCAGGUGCUUGUGGCCUCUCGUGGCAG PPVGPHSCPLHQEVLHPSSCLGLWEAGS GCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACA GGCAGUCUGCGGCGGUGUUCUGGUGCACC ARSIPNPGRCLWPLVAGQSAAVFWCTPS GCTGCCCACTGCATCAGGAAGTGCTGCACCCCTCA CCCAGUGGGUCCUCACAGCUGCCCACUGCA GSSQLPTASG TCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGA UCAGGAAGUGCUGCACCCCUCAUCCUGUC GAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCT UCGGAUUGUGGGAGGCUGGGAGUGCGAG CTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGT AAGCAUUCCCAACCCUGGCAGGUGCUUGU GCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCA GGCCUCUCGUGGCAGGGCAGUCUGCGGCG TCAGGA GUGUUCUGGUGCACCCCCAGUGGGUCCUC ACAGCUGCCCACUGCAUCAGGA 10(BSS) 10/309 GTGCTGGACGCTGGACAGGGGGCAAAAGCACCT GUGCUGGACGCUGGACAGGGGGCAAAAGC VLDAGQGAKAPARLDPKETSVCGPPCYF GCTCGTCTTGACCCCAAAGAAACTTCAGTGTGTGGACC UGCUCGUCUUGACCCCAAAGAAACUUC Q ACCTCCATGTTATTTCCAATGA AGUGUGUGGACCUCCAUGUUAUUUCCAAU GA 11(BSS) 11/310 GTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAG GUGUGCGCAAGUUCACCCUCAGAAGGUGA VCASSPSEGDQVHAVCWTLDRGQKHLL TTCATGCTGTGTGCTGGACGCTGGACAGGGGGCA CCAAGUUCAUGCUGUGUGCUGGACGCUGG VLTPKKLQCVDLHVISNDVCAQVHPQKV AAAGCACCTGCTCGTCTTGACCCCAAAGAAACTTC ACAGGGGGCAAAAGCACCUGCUCGUCUUG TKFMLCAGRWTGGKSTCS AGTGTGTGGACCTCCATGTTATTTCCAATGACGTG ACCCCAAAGAAACUUCAGUGUGUGGACCU TGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGT CCAUGUUAUUUCCAAUGACGUGUGUGCGC TCATGCTGTGTGCTGGACGCTGGACAGGGGGCAA AAGUUCACCCUCAGAAGGUGACCAAGUUC AAGCACCTGCTCG AUGCUGUGUGCUGGACGCUGGACAGGGG GCAAAAGCACCUGCUCG 12(BSS) 12/311 ATGTGCCCTGCCCGAAAGGCCTTCCCTGTACACCA AUGUGCCCUGCCCGAAAGGCCUUCCCUGU MCPARKAFPVHQGGALPEVDQGHHRG AGGTGGTGCATTACCGGAAGTGGATCAAGGACAC ACACCAAGGUGGUGCAUUACCGGAAGUGG QPLSTPINPLL CATCGTGGCCAACCCCTGAGCACCCCTATCAACCC AUCAAGGACACCAUCGUGGCCAACCCCUGA CCTATTGTAG GCACCCCUAUCAACCCCCUAUUGUAG 13(BSS) 13/312 CTGATTCACTATGGGGGGAGGTGTATTGAAGTCC CUGAUUCACUAUGGGGGGAGGUGUAUUG LIHYGGRCIEVLQTTLRFDDFLVELTEIKSC TCCAGACAACCCTCAGATTTGATGATTTCCTAGTA AAGUCCUCCAGACAACCCUCAGAUUUGAU YTVGDSGGPLVCNGVLQGITSWGSEPCA GAACTCACAGAAATAAAGAGCTGTTATACTGTGG GAUUUCCUAGUAGAACUCACAGAAAUAAA LPERPSLYTKVVHYRKWIKDTIVANP GTGATTCTGGGGGCCCACTTGTCTGTAATGGTGTG GAGCUGUUAUACUGUGGGUGAUUCUGGG CTTCAAGGTATCACGTCATGGGGCAGTGAACCAT GGCCCACUUGUCUGUAAUGGUGUGCUUCA GTGCCCTGCCCGAAAGGCCTTCCCTGTACACCAAG AGGUAUCACGUCAUGGGGCAGUGAACCAU GTGGTGCATTACCGGAAGTGGATCAAGGACACCA GUGCCCUGCCCGAAAGGCCUUCCCUGUACA TCGTGGCCAACCCCTGA CCAAGGUGGUGCAUUACCGGAAGUGGAUC AAGGACACCAUCGUGGCCAACCCCUGA 14 14/313 GTGATCTTGCTGGGTCGGCACAGCCTGTTTCATCC GUGAUCUUGCUGGGUCGGCACAGCCUGUU VILLGRHSLFHPEDTGQVFQVSHSFPHPL (BSS+RCA) TGAAGACACAGGCCAGGTATTTCAGGTCAGCCAC UCAUCCUGAAGACACAGGCCAGGUAUUUC YDMSLLKNRFLRPGDDSSHDLMLLRLSEP AGCTTCCCACACCCGCTCTACGATATGAGCCTCCT AGGUCAGCCACAGCUUCCCACACCCGCUCU AELTDAVKVMDLPTQEPALGTTCYASG GAAGAATCGATTCCTCAGGCCAGGTGATGACTCC ACGAUAUGAGCCUCCUGAAGAAUCGAUUC WGSIEPEECAAPLILSRIVGGWECEKHSQ AGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCC CUCAGGCCAGGUGAUGACUCCAGCCACGAC PWQVLVASRGRAVCGGVLVHPQWVLT TGCCGAGCTCACGGATGCTGTGAAGGTCATGGAC CUCAUGCUGCUCCGCCUGUCAGAGCCUGC AAHCIR CTGCCCACCCAGGAGCCAGCACTGGGGACCACCT CGAGCUCACGGAUGCUGUGAAGGUCAUGG GCTACGCCTCAGGCTGGGGCAGCATTGAACCAGA ACCUGCCCACCCAGGAGCCAGCACUGGGGA GGAGTGTGCTGCACCCCTCATCCTGTCTCGGATTG CCACCUGCUACGCCUCAGGCUGGGGCAGCA TGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACC UUGAACCAGAGGAGUGUGCUGCACCCCUC CTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCA AUCCUGUCUCGGAUUGUGGGAGGCUGGG GTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGG AGUGCGAGAAGCAUUCCCAACCCUGGCAG TCCTCACA GUGCUUGUGGCCUCUCGUGGCAGGGCAG UCUGCGGCGGUGUUCUGGUGCACCCCCAG UGGGUCCUCACA PCA3neo- antigen DNAsequence RNAsequence ProteinSequence 1 15/314 CTGGCATCAGAAAAACAGAGGGGAGATTTGTGTG CUGGCAUCAGAAAAACAGAGGGGAGAUUU LASEKQRGDLCGCSRGRPGRSAWWEGP GCTGCAGCCGAGGGAGACCAGGAAGATCTGCAT GUGUGGCUGCAGCCGAGGGAGACCAGGAA DDTEVRNKKGC GGTGGGAAGGACCTGATGATACAGAGGTGAGAA GAUCUGCAUGGUGGGAAGGACCUGAUGA ATAAGAAAGGCTGCTGA UACAGAGGUGAGAAAUAAGAAAGGCUGCU GA 2 16/315 GTGCCTGGTCCCGCTTGTGAGGGAAGGACATTAG GUGCCUGGUCCCGCUUGUGAGGGAAGGAC VPGPACEGRTLENELMCSLKDGQENRSC AAAATGAATTGATGTGTTCCTTAAAGGATGGGCA AUUAGAAAAUGAAUUGAUGUGUUCCUUA CGYLFERDYRFEMKSQSEHYQ GGAAAACAGATCCTGTTGTGGATATTTATTTGAAC AAGGAUGGGCAGGAAAACAGAUCCUGUUG GGGATTACAGATTTGAAATGAAGTCACAAAGTGA UGGAUAUUUAUUUGAACGGGAUUACAGA GCATTACCAATGA UUUGAAAUGAAGUCACAAAGUGAGCAUUA CCAAUGA 3 17/316 ATGGAATACTGTGATGACATGAGGCAGCCAAGCT AUGGAAUACUGUGAUGACAUGAGGCAGCC MEYCDDMRQPSWGGDNHGAEGQDSG GGGGAGGAGATAACCACGGGGCAGAGGGTCAGG AAGCUGGGGAGGAGAUAACCACGGGGCAG PAA ATTCTGGCCCTGCTGCCTAA AGGGUCAGGAUUCUGGCCCUGCUGCCUAA 4 18/317 CTGATCTCTACGGTTCCTTCTGGGCCCAACATTCTC CUGAUCUCUACGGUUCCUUCUGGGCCCAA LISTVPSGPNILHISSHTHF CATATATCCAGCCACACTCATTTTTAA CAUUCUCCAUAUAUCCAGCCACACUCAUUU UUAA 5 19/318 GTGTTCTGGCCCAGGGGATCTGTGAACAGGCTGG GUGUUCUGGCCCAGGGGAUCUGUGAACAG VFWPRGSVNRLGSISRSFQGYTY GAAGCATCTCAAGATCTTTCCAGGGTTATACTTAC GCUGGGAAGCAUCUCAAGAUCUUUCCAGG TAG GUUAUACUUACUAG 6 20/319 GTGCCCATTCTCAAGACCTCAAAATGTCATTCCATT GUGCCCAUUCUCAAGACCUCAAAAUGUCA VPILKTSKCHSINITGLTFFFNLEEFNVTCS AATATCACAGGATTAACTTTTTTTTTTAACCTGGAA UUCCAUUAAUAUCACAGGAUUAACUUUUU YGNLITYFVFQCKDD GAATTCAATGTTACATGCAGCTATGGGAATTTAAT UUUUUAACCUGGAAGAAUUCAAUGUUACA TACATATTTTGTTTTCCAGTGCAAAGATGACTAA UGCAGCUAUGGGAAUUUAAUUACAUAUU UUGUUUUCCAGUGCAAAGAUGACUAA 7 21/320 TTGAACATGTCAGGCATACATTATTCCTTCTGCCTG UUGAACAUGUCAGGCAUACAUUAUUCCUU LNMSGIHYSFCLRSSSLSLKSRMM AGAAGCTCTTCCTTGTCTCTTAAATCTAGAATGAT CUGCCUGAGAAGCUCUUCCUUGUCUCUUA GTAA AAUCUAGAAUGAUGUAA 8 22/321 CTGGCAATAAAGAATTTACAAAGAGCTACTCAGG CUGGCAAUAAAGAAUUUACAAAGAGCUAC LAIKNLQRATQDQLLRALCVCVCV ACCAGTTGTTAAGAGCTCTGTGTGTGTGTGTGTGT UCAGGACCAGUUGUUAAGAGCUCUGUGU GTGTGA GUGUGUGUGUGUGUGUGA 9 23/322 GTGTACATGCCAAAGTGTGCCTCTCTCTCTTTGAC GUGUACAUGCCAAAGUGUGCCUCUCUCUC VYMPKCASLSLTHYFRLKNKHVFKWHYE CCATTATTTCAGACTTAAAAACAAGCATGTTTTCAA UUUGACCCAUUAUUUCAGACUUAAAAACA LPMMYHHHISLFSSKCDNNVIC ATGGCACTATGAGCTGCCAATGATGTATCACCACC AGCAUGUUUUCAAAUGGCACUAUGAGCUG ATATCTCATTATTCTCCAGTAAATGTGATAATAATG CCAAUGAUGUAUCACCACCAUAUCUCAUU TCATCTGTTAA AUUCUCCAGUAAAUGUGAUAAUAAUGUCA UCUGUUAA 10 24/323 TTGACTTCACAAAAGCAGCTGGAAATGGACAACC UUGACUUCACAAAAGCAGCUGGAAAUGGA LTSQKQLEMDNHNMHKSNSYHQLHTA ACAATATGCATAAATCTAACTCCTACCATCAGCTA CAACCACAAUAUGCAUAAAUCUAACUCCUA CACACTGCTTGA CCAUCAGCUACACACUGCUUGA 11 25/324 CTGAGCTGTCATCGTCCCCATCTCTGTGAGCCACA CUGAGCUGUCAUCGUCCCCAUCUCUGUGA LSCHRPHLCEPQPTAGPNACLRSLNQGN ACCAACAGCAGGACCCAACGCATGTCTGAGATCC GCCACAACCAACAGCAGGACCCAACGCAUG QCHELNSPIMDASFWPSLALLLTHISF TTAAATCAAGGAAACCAGTGTCATGAGTTGAATTC UCUGAGAUCCUUAAAUCAAGGAAACCAGU TCCTATTATGGATGCTAGCTTCTGGCCATCTCTGG GUCAUGAGUUGAAUUCUCCUAUUAUGGA CTCTCCTCTTGACACATATTAGCTTCTAG UGCUAGCUUCUGGCCAUCUCUGGCUCUCC UCUUGACACAUAUUAGCUUCUAG 12 26/325 TTGCTTCCACGACTTTTATCTTTTCTCCAACACATC UUGCUUCCACGACUUUUAUCUUUUCUCCA LLPRLLSFLQHIAYQSSLCSVALDFPTRIST GCTTACCAATCCTCTCTCTGCTCTGTTGCTTTGGAC ACACAUCGCUUACCAAUCCUCUCUCUGCUC TLKSFLPSPPLT TTCCCCACAAGAATTTCAACGACTCTCAAGTCTTTT UGUUGCUUUGGACUUCCCCACAAGAAUUU CTTCCATCCCCACCACTAACCTGA CAACGACUCUCAAGUCUUUUCUUCCAUCCC CACCACUAACCUGA 13 27/326 ATGCCTAGACCCTTATTTTTATTAATTTCCAATAGA AUGCCUAGACCCUUAUUUUUAUUAAUUUC MPRPLFLLISNRCCLWAILL TGCTGCCTATGGGCTATATTGCTTTAG CAAUAGAUGCUGCCUAUGGGCUAUAUUGC UUUAG 14 28/327 ATGAACATTAGATATTTAAAGCTCAAGAGGTTCAA AUGAACAUUAGAUAUUUAAAGCUCAAGAG MNIRYLKLKRFKIQLIIFSFFHLPAPLPILLIA AATCCAACTCATTATCTTCTCTTTCTTTCACCTCCCT GUUCAAAAUCCAACUCAUUAUCUUCUCUU LNSMVPNVAMQMRNPVAPCGTCMQD GCTCCTCTCCCTATATTACTGATTGCACTGAACAGC UCUUUCACCUCCCUGCUCCUCUCCCUAUAU C ATGGTCCCCAATGTAGCCATGCAAATGAGAAACC UACUGAUUGCACUGAACAGCAUGGUCCCC CAGTGGCTCCTTGTGGTACATGCATGCAAGACTGC AAUGUAGCCAUGCAAAUGAGAAACCCAGU TGA GGCUCCUUGUGGUACAUGCAUGCAAGACU GCUGA 15 29/328 GTGCCGAGAAGCTGGCATCAGAAAAACAGAGGG GUGCCGAGAAGCUGGCAUCAGAAAAACAG VPRSWHQKNRGEICVAAAEGDQEDLHG GAGATTTGTGTGGCTGCAGCCGAGGGAGACCAG AGGGGAGAUUUGUGUGGCUGCAGCCGAG GKDLMIQR GAAGATCTGCATGGTGGGAAGGACCTGATGATAC GGAGACCAGGAAGAUCUGCAUGGUGGGAA AGAGGTGA GGACCUGAUGAUACAGAGGUGA 16 30/329 ATGTTTTTGCACATTTCCAGCCCCTTTAAATATCCA AUGUUUUUGCACAUUUCCAGCCCCUUUAA MFLHISSPFKYPHTQEAQKEAQRSLGEM CACACACAGGAAGCACAAAAGGAAGCACAGAGA AUAUCCACACACACAGGAAGCACAAAAGGA PGRHLGSSMSLALCLVPLVREGH TCCCTGGGAGAAATGCCCGGCCGCCATCTTGGGT AGCACAGAGAUCCCUGGGAGAAAUGCCCG CATCGATGAGCCTCGCCCTGTGCCTGGTCCCGCTT GCCGCCAUCUUGGGUCAUCGAUGAGCCUC GTGAGGGAAGGACATTAG GCCCUGUGCCUGGUCCCGCUUGUGAGGGA AGGACAUUAG 17 31/330 ATGGGCAGGAAAACAGATCCTGTTGTGGATATTT AUGGGCAGGAAAACAGAUCCUGUUGUGGA MGRKTDPVVDIYLNGITDLK ATTTGAACGGGATTACAGATTTGAAATGA UAUUUAUUUGAACGGGAUUACAGAUUUG AAAUGA 18 32/331 GTGAGCATTACCAATGAGAGGAAAACAGACGAG GUGAGCAUUACCAAUGAGAGGAAAACAGA VSITNERKTDEKILMASQDMQQTKWNT AAAATCTTGATGGCTTCACAAGACATGCAACAAAC CGAGAAAAUCUUGAUGGCUUCACAAGACA VMT AAAATGGAATACTGTGATGACATGA UGCAACAAACAAAAUGGAAUACUGUGAUG ACAUGA 19 33/332 GTGAATTATCTAATCAACATCATCCTCAGTGTCTTT GUGAAUUAUCUAAUCAACAUCAUCCUCAG VNYLINIILSVFAHTEIHFPLLCPFSRPQNVI GCCCATACTGAAATTCATTTCCCACTTTTGTGCCCA UGUCUUUGCCCAUACUGAAAUUCAUUUCC PLISQD TTCTCAAGACCTCAAAATGTCATTCCATTAATATCA CACUUUUGUGCCCAUUCUCAAGACCUCAA CAGGATTAA AAUGUCAUUCCAUUAAUAUCACAGGAUUA A 20 34/333 TTGTTTTCCAGTGCAAAGATGACTAAGTCCTTTATC UUGUUUUCCAGUGCAAAGAUGACUAAGUC LFSSAKMTKSFIPPLCLIFFPV CCTCCCCTTTGTTTGATTTTTTTTCCAGTATA CUUUAUCCCUCCCCUUUGUUUGAUUUUU UUUCCAGUAUA 21 35/334 ATGCAAGAGCCACAGAGGGAATGTTTATGGGGCA AUGCAAGAGCCACAGAGGGAAUGUUUAUG MQEPQRECLWGTFVSLGCEAKAGNLIVS CGTTTGTAAGCCTGGGATGTGAAGCAAAGGCAGG GGGCACGUUUGUAAGCCUGGGAUGUGAA YIIYFISLSLSQYPTSFSQNSCSANPQR GAACCTCATAGTATCTTATATAATATACTTCATTTC GCAAAGGCAGGGAACCUCAUAGUAUCUUA TCTATCTCTATCACAATATCCAACAAGCTTTTCACA UAUAAUAUACUUCAUUUCUCUAUCUCUAU GAATTCATGCAGTGCAAATCCCCAAAGGTAA CACAAUAUCCAACAAGCUUUUCACAGAAU UCAUGCAGUGCAAAUCCCCAAAGGUAA 22 36/335 GTGGGTTCTCTTAAGCAAAATACTTGCATTAGGTC GUGGGUUCUCUUAAGCAAAAUACUUGCAU VGSLKQNTCIRSQLGLCIRRFEKYSILSRSQ TCAGCTGGGGCTGTGCATCAGGCGGTTTGAGAAA UAGGUCUCAGCUGGGGCUGUGCAUCAGGC NLNSLIF TATTCAATTCTCAGCAGAAGCCAGAATTTGAATTC GGUUUGAGAAAUAUUCAAUUCUCAGCAGA CCTCATCTTTTAG AGCCAGAAUUUGAAUUCCCUCAUCUUUUA G 23 37/336 CTGTCCCTCTTTGTGTTCATGGATAGTCCAATAAAT CUGUCCCUCUUUGUGUUCAUGGAUAGUCC LSLFVFMDSPINNVIFELMLIGENIRTLSDI AATGTTATCTTTGAACTGATGCTCATAGGAGAGAA AAUAAAUAAUGUUAUCUUUGAACUGAUGC NIRDSKKY TATAAGAACTCTGAGTGATATCAACATTAGGGATT UCAUAGGAGAGAAUAUAAGAACUCUGAGU CAAAGAAATATTAG GAUAUCAACAUUAGGGAUUCAAAGAAAUA UUAG 24 38/337 CTGTTGCTTTGGACTTCCCCACAAGAATTTCAACG CUGUUGCUUUGGACUUCCCCACAAGAAUU LLLWTSPQEFQRLSSLFFHPHH ACTCTCAAGTCTTTTCTTCCATCCCCACCACTAA UCAACGACUCUCAAGUCUUUUCUUCCAUC CCCACCACUAA 25 39/338 GTGGTACATGCATGCAAGACTGCTGAAGCCAGAA GUGGUACAUGCAUGCAAGACUGCUGAAGC VVHACKTAEARRMTDYASWVEGTTPGP GGATGACTGATTACGCCTCATGGGTGGAGGGGAC CAGAAGGAUGACUGAUUACGCCUCAUGGGS CACTCCTGGGCCTTCGTGA UGGAGGGGACCACUCCUGGGCCUUCGUGA 26 40/339 TTGTCAGGAGCAAGACCTGAGATGCTCCCTGCCTT UUGUCAGGAGCAAGACCUGAGAUGCUCCC LSGARPEMLPAFSVLCISPF CAGTGTCCTCTGCATCTCCCCTTTCTAA UGCCUUCAGUGUCCUCUGCAUCUCCCCUU UCUAA 27 41/340 TTGGCATACTATATCAACTTTGATTCTTTGTTACAA UUGGCAUACUAUAUCAACUUUGAUUCUU LAYYINFDSLLQLFLLFYHQSGFYSLYYYYF CTTTTCTTACTCTTTTATCACCAAAGTGGCTTTTATT UGUUACAACUUUUCUUACUCUUUUAUCAC LLLLYYVVIILFSIVSIYLI CTCTTTATTATTATTATTTTCTTTTACTACTATATTA CAAAGUGGCUUUUAUUCUCUUUAUUAUU CGTTGTTATTATTTTGTTCTCTATAGTATCAATTTAT AUUAUUUUCUUUUACUACUAUAUUACGU TTGATTTAG UGUUAUUAUUUUGUUCUCUAUAGUAUCA AUUUAUUUGAUUUAG 28 42/341 GTGACATGTTTTTGCACATTTCCAGCCCCTTTAAAT GUGACAUGUUUUUGCACAUUUCCAGCCCC VTCFCTFPAPLNIHTHRKHKRKHRDPWE ATCCACACACACAGGAAGCACAAAAGGAAGCACA UUUAAAUAUCCACACACACAGGAAGCACAA KCPAAILGHR GAGATCCCTGGGAGAAATGCCCGGCCGCCATCTT AAGGAAGCACAGAGAUCCCUGGGAGAAAU GGGTCATCGATGA GCCCGGCCGCCAUCUUGGGUCAUCGAUGA 29 43/342 GTGACCTTTCTACACTGTAGAATAACATTACTCATT GUGACCUUUCUACACUGUAGAAUAACAUU VTFLHCRITLLILFKDPSCCCLICS TTGTTCAAAGACCCTTCGTGTTGCTGCCTAATATGT ACUCAUUUUGUUCAAAGACCCUUCGUGUU AGCTGA GCUGCCUAAUAUGUAGCUGA 30 44/343 CTGTTTTTCCTAAGGAGTGTTCTGGCCCAGGGGAT CUGUUUUUCCUAAGGAGUGUUCUGGCCCA LFFLRSVLAQGICEQAGKHLKIFPGLYLLA CTGTGAACAGGCTGGGAAGCATCTCAAGATCTTTC GGGGAUCUGUGAACAGGCUGGGAAGCAUC HSMIITE CAGGGTTATACTTACTAGCACACAGCATGATCATT UCAAGAUCUUUCCAGGGUUAUACUUACUA ACGGAGTGA GCACACAGCAUGAUCAUUACGGAGUGA 31 45/344 GTGTCTTTGCCCATACTGAAATTCATTTCCCACTTT GUGUCUUUGCCCAUACUGAAAUUCAUUUC VSLPILKFISHFCAHSQDLKMSFH TGTGCCCATTCTCAAGACCTCAAAATGTCATTCCAT CCACUUUUGUGCCCAUUCUCAAGACCUCA TAA AAAUGUCAUUCCAUUAA 32 46/345 ATGCTTAGCCTTGTACTGAGGCTGTATACAGCCAC AUGCUUAGCCUUGUACUGAGGCUGUAUAC MLSLVLRLYTATASPHPSSLICHHHQPLPC AGCCTCTCCCCATCCCTCCAGCCTTATCTGTCATCA AGCCACAGCCUCUCCCCAUCCCUCCAGCCU T CCATCAACCCCTCCCATGCACCTAA UAUCUGUCAUCACCAUCAACCCCUCCCAUG CACCUAA 33 47/346 ATGCAAAGAAGGGACACATATGAGATTCATCATC AUGCAAAGAAGGGACACAUAUGAGAUUCA MQRRDTYEIHHHMRQQILKV ACATGAGACAGCAAATACTAAAAGTGTAA UCAUCACAUGAGACAGCAAAUACUAAAAG UGUAA 34 48/347 GTGCAAATCCCCAAAGGTAACCTTTATCCATTTCAT GUGCAAAUCCCCAAAGGUAACCUUUAUCC VQIPKGNLYPFHGECALEFWQIILVTYLNF GGTGAGTGCGCTTTAGAATTTTGGCAAATCATACT AUUUCAUGGUGAGUGCGCUUUAGAAUUU EMCLSL GGTCACTTATCTCAACTTTGAGATGTGTTTGTCCTT UGGCAAAUCAUACUGGUCACUUAUCUCAA GTAG CUUUGAGAUGUGUUUGUCCUUGUAG 35 49/348 GTGTGTGTGTGTGTGTGTGTGAGTGTACATGCCA GUGUGUGUGUGUGUGUGUGUGAGUGUA VCVCVCVSVHAKVCLSLFDPLFQT AAGTGTGCCTCTCTCTCTTTGACCCATTATTTCAGA CAUGCCAAAGUGUGCCUCUCUCUCUUUGA CTTAA CCCAUUAUUUCAGACUUAA 36 50/349 TTGACATATATTGTTAGAAGCACCTCGCATTTGTG UUGACAUAUAUUGUUAGAAGCACCUCGCA LTYIVRSTSHLWVLLSKILALGLSWGCASG GGTTCTCTTAAGCAAAATACTTGCATTAGGTCTCA UUUGUGGGUUCUCUUAAGCAAAAUACUU GLRNIQFSAEARI GCTGGGGCTGTGCATCAGGCGGTTTGAGAAATAT GCAUUAGGUCUCAGCUGGGGCUGUGCAUC TCAATTCTCAGCAGAAGCCAGAATTTGA AGGCGGUUUGAGAAAUAUUCAAUUCUCAG CAGAAGCCAGAAUUUGA 37 51/350 TTGGAGAGGATTCAGACAGCTCAGGTGCTTTCACT UUGGAGAGGAUUCAGACAGCUCAGGUGCU LERIQTAQVLSLMSLNFCPSLCSWIVQ AATGTCTCTGAACTTCTGTCCCTCTTTGTGTTCATG UUCACUAAUGUCUCUGAACUUCUGUCCCU GATAGTCCAATAA CUUUGUGUUCAUGGAUAGUCCAAUAA 38 52/351 GTGATATCAACATTAGGGATTCAAAGAAATATTAG GUGAUAUCAACAUUAGGGAUUCAAAGAAA VISTLGIQRNIRFKLTLVKRNQDTKNSELS ATTTAAGCTCACACTGGTCAAAAGGAACCAAGAT UAUUAGAUUUAAGCUCACACUGGUCAAAA SSPSL ACAAAGAACTCTGAGCTGTCATCGTCCCCATCTCT GGAACCAAGAUACAAAGAACUCUGAGCUG GTGA UCAUCGUCCCCAUCUCUGUGA 39 53/352 CTGCTCTGTTGCTTTGGACTTCCCCACAAGAATTTC CUGCUCUGUUGCUUUGGACUUCCCCACAA LLCCFGLPHKNFNDSQVFSSIPTTNLNA AACGACTCTCAAGTCTTTTCTTCCATCCCCACCACT GAAUUUCAACGACUCUCAAGUCUUUUCUU AACCTGAATGCCTAG CCAUCCCCACCACUAACCUGAAUGCCUAG 40 54/353 CTGATTACGCCTCATGGGTGGAGGGGACCACTCC CUGAUUACGCCUCAUGGGUGGAGGGGACC ITPHGWRGPLLGLRDCQEQDLRCSLPSVS TGGGCCTTCGTGATTGTCAGGAGCAAGACCTGAG ACUCCUGGGCCUUCGUGAUUGUCAGGAGC SASPLSNEDP ATGCTCCCTGCCTTCAGTGTCCTCTGCATCTCCCCT AAGACCUGAGAUGCUCCCUGCCUUCAGUG TTCTAATGAAGATCCATAG UCCUCUGCAUCUCCCCUUUCUAAUGAAGA UCCAUAG 41 55/354 TTGCTACATTTGAGAATTCCAATTAGGAACTCACA UUGCUACAUUUGAGAAUUCCAAUUAGGAA LLHLRIPIRNSHVLSALSIF TGTTTTATCTGCCCTATCAATTTTTTAA CUCACAUGUUUUAUCUGCCCUAUCAAUUU UUUAA 42 56/355 GTGTCTTGGCATACTATATCAACTTTGATTCTTTGT GUGUCUUGGCAUACUAUAUCAACUUUGA VSWHTISTLILCYNFSYSFITKVAFILFIIIIFF TACAACTTTTCTTACTCTTTTATCACCAAAGTGGCT UUCUUUGUUACAACUUUUCUUACUCUUU YYYITLLLFCSL TTTATTCTCTTTATTATTATTATTTTCTTTTACTACTA UAUCACCAAAGUGGCUUUUAUUCUCUUUA TATTACGTTGTTATTATTTTGTTCTCTATAG UUAUUAUUAUUUUCUUUUACUACUAUAU UACGUUGUUAUUAUUUUGUUCUCUAUAG 43 57/356 TTGCTGACTTTTAAAATAAGTGATTCGGGGGGTG UUGCUGACUUUUAAAAUAAGUGAUUCGG LLTFKISDSGGGRTGEGEH GGAGAACAGGGGAGGGAGAGCATTAG GGGGUGGGAGAACAGGGGAGGGAGAGCA UUAG 44 58/357 GTGCAGCAAACCACTATGGCACACGTATACCTGTG GUGCAGCAAACCACUAUGGCACACGUAUA VQQTTMAHVYLCNKPTHSAHVSQNVK TAACAAACCTACACATTCTGCACATGTATCCCAGA CCUGUGUAACAAACCUACACAUUCUGCACA ACGTAAAGTAA UGUAUCCCAGAACGUAAAGUAA 45(BSS) 59/358 GTGCAGCAAAGAAAGACTACAGACATCTCAATGG GUGCAGCAAAGAAAGACUACAGACAUCUC VQQRKTTDISMAGELQHIYLVFQ CAGGGGAATTACAACACATATACTTAGTGTTTCAA AAUGGCAGGGGAAUUACAACACAUAUACU TGA UAGUGUUUCAAUGA 46(BSS) 60/359 GTGAGTCTCCTCAGTGACACAGGGCTGGATCACC GUGAGUCUCCUCAGUGACACAGGGCUGGA VSLLSDTGLDHHRRHFLSTQCSKERLQTS ATCGACGGCACTTTCTGAGTACTCAGTGCAGCAAA UCACCAUCGACGGCACUUUCUGAGUACUC QWQGNYNTYT GAAAGACTACAGACATCTCAATGGCAGGGGAATT AGUGCAGCAAAGAAAGACUACAGACAUCU ACAACACATATACTTAG CAAUGGCAGGGGAAUUACAACACAUAUAC UUAG 47(BSS) 61/360 GTGACATGTTTTTGCACATTTCCAGCCCCTTTAAAT GUGACAUGUUUUUGCACAUUUCCAGCCCC VTCFCTFPAPLNIHTHRKHKRKHRGEK ATCCACACACACAGGAAGCACAAAAGGAAGCACA UUUAAAUAUCCACACACACAGGAAGCACAA GAGGTGAGAAATAA AAGGAAGCACAGAGGUGAGAAAUAA 48(BSS) 62/361 GTGCAGCAAAGAAAGACTACAGACATCTCAATGG GUGCAGCAAAGAAAGACUACAGACAUCUC VQQRKTTDISMAGELQHIYLVFQ CAGGGGAATTACAACACATATACTTAGTGTTTCAA AAUGGCAGGGGAAUUACAACACAUAUACU TGA UAGUGUUUCAAUGA 49(BSS) 63/362 ATGTTTTTGCACATTTCCAGCCCCTTTAAATATCCA AUGUUUUUGCACAUUUCCAGCCCCUUUAA MFLHISSPFKYPHTQEAQKEAQRNYNTY CACACACAGGAAGCACAAAAGGAAGCACAGAGG AUAUCCACACACACAGGAAGCACAAAAGGA T AATTACAACACATATACTTAG AGCACAGAGGAAUUACAACACAUAUACUU AG 50(BSS) 64/363 GTGACATGTTTTTGCACATTTCCAGCCCCTTTAAAT GUGACAUGUUUUUGCACAUUUCCAGCCCC VTCFCTFPAPLNIHTHRKHKRKHRGITTHI ATCCACACACACAGGAAGCACAAAAGGAAGCACA UUUAAAUAUCCACACACACAGGAAGCACAA LSVSMNTKINK GAGGAATTACAACACATATACTTAGTGTTTCAATG AAGGAAGCACAGAGGAAUUACAACACAUA AACACCAAGATAAATAAGTGA UACUUAGUGUUUCAAUGAACACCAAGAUA AAUAAGUGA ARneo- antigen DNAsequence RNAsequence Proteinsequence 1 65/364 CTGCCTTCCCCACCCCGAGTGCGGAGCCAGAGAT CUGCCUUCCCCACCCCGAGUGCGGAGCCAG LPSPPRVRSQRSKDEKAVRSSVAKKQNK CAAAAGATGAAAAGGCAGTCAGGTCTTCAGTAGC AGAUCAAAAGAUGAAAAGGCAGUCAGGUC QKQKSRNKRKR CAAAAAACAAAACAAACAAAAACAAAAAAGCCGA UUCAGUAGCCAAAAAACAAAACAAACAAAA AATAAAAGAAAAAGATAA ACAAAAAAGCCGAAAUAAAAGAAAAAGAUA A 2 66/365 TTGCACCTACTTCAGTGGACACTGAATTTGGAAGG UUGCACCUACUUCAGUGGACACUGAAUUU LHLLQWTLNLEGGGFCFFLLRSGHLLNLP TGGAGGATTTTGTTTTTTTCTTTTAAGATCTGGGCA GGAAGGUGGAGGAUUUUGUUUUUUUCUU FKY TCTTTTGAATCTACCCTTCAAGTATTAA UUAAGAUCUGGGCAUCUUUUGAAUCUACC CUUCAAGUAUUAA 3 67/366 GTGTCTTCTTCTGCACGAGACTTTGAGGCTGTCAG GUGUCUUCUUCUGCACGAGACUUUGAGGC VSSSARDFEAVRALFAWLLPQVSFSGASR AGCGCTTTTTGCGTGGTTGCTCCCGCAAGTTTCCTT UGUCAGAGCGCUUUUUGCGUGGUUGCUC RWAASCSDYRIITAC CTCTGGAGCTTCCCGCAGGTGGGCAGCTAGCTGC CCGCAAGUUUCCUUCUCUGGAGCUUCCCG AGCGACTACCGCATCATCACAGCCTGTTGA CAGGUGGGCAGCUAGCUGCAGCGACUACC GCAUCAUCACAGCCUGUUGA 4 68/367 CTGAGCAAGAGAAGGGGAGGCGGGGTAAGGGA CUGAGCAAGAGAAGGGGAGGCGGGGUAAG LSKRRGGGVREVGGRFSQAQGWKCS AGTAGGTGGAAGATTCAGCCAAGCTCAAGGATGG GGAAGUAGGUGGAAGAUUCAGCCAAGCUC AAGTGCAGTTAG AAGGAUGGAAGUGCAGUUAG 5 69/368 GTGAGGATGGTTCTCCCCAAGCCCATCGTAGAGG GUGAGGAUGGUUCUCCCCAAGCCCAUCGU VRMVLPKPIVEAPQATWSWMRNSNLH CCCCACAGGCTACCTGGTCCTGGATGAGGAACAG AGAGGCCCCACAGGCUACCUGGUCCUGGA SRSRPWSATPREVASQSLEPPWPPARGC CAACCTTCACAGCCGCAGTCGGCCCTGGAGTGCC UGAGGAACAGCAACCUUCACAGCCGCAGUC RSSCQHLRTRMTQLPHPRCPCWAPLSPA ACCCCGAGAGAGGTTGCGTCCCAGAGCCTGGAGC GGCCCUGGAGUGCCACCCCGAGAGAGGUU CGCCGTGGCCGCCAGCAAGGGGCTGCCGCAGCA GCGUCCCAGAGCCUGGAGCCGCCGUGGCC GCTGCCAGCACCTCCGGACGAGGATGACTCAGCT GCCAGCAAGGGGCUGCCGCAGCAGCUGCCA GCCCCATCCACGTTGTCCCTGCTGGGCCCCACTTT GCACCUCCGGACGAGGAUGACUCAGCUGC CCCCGGCTTAA CCCAUCCACGUUGUCCCUGCUGGGCCCCAC UUUCCCCGGCUUAA 6 70/369 CTGACAACGCCAAGGAGTTGTGTAAGGCAGTGTC CUGACAACGCCAAGGAGUUGUGUAAGGCA LTTPRSCVRQCRCPWAWVWRRWSI GGTGTCCATGGGCCTGGGTGTGGAGGCGTTGGA GUGUCGGUGUCCAUGGGCCUGGGUGUGG GCATCTGA AGGCGUUGGAGCAUCUGA 7 71/370 GTGTCAAAAGCGAAATGGGCCCCTGGATGGATAG GUGUCAAAAGCGAAAUGGGCCCCUGGAUG VSKAKWAPGWIATPDLTGTCVWRLPGT CTACTCCGGACCTTACGGGGACATGCGTTTGGAG GAUAGCUACUCCGGACCUUACGGGGACAU MFCPLTITFHPRRPA ACTGCCAGGGACCATGTTTTGCCCATTGACTATTA GCGUUUGGAGACUGCCAGGGACCAUGUUU CTTTCCACCCCAGAAGACCTGCCTGA UGCCCAUUGACUAUUACUUUCCACCCCAG AAGACCUGCCUGA 8 72/371 GTGGAGATGAAGCTTCTGGGTGTCACTATGGAGC GUGGAGAUGAAGCUUCUGGGUGUCACUA VEMKLLGVTMELSHVEAARSSSKEPLKG TCTCACATGTGGAAGCTGCAAGGTCTTCTTCAAAA UGGAGCUCUCACAUGUGGAAGCUGCAAGG NRSTCAPAEMIALLINSEGKIVHLVVFGN GAGCCGCTGAAGGGAAACAGAAGTACCTGTGCGC UCUUCUUCAAAAGAGCCGCUGAAGGGAAA VMKQG CAGCAGAAATGATTGCACTATTGATAAATTCCGAA CAGAAGUACCUGUGCGCCAGCAGAAAUGA GGAAAAATTGTCCATCTTGTCGTCTTCGGAAATGT UUGCACUAUUGAUAAAUUCCGAAGGAAAA TATGAAGCAGGGATGA AUUGUCCAUCUUGUCGUCUUCGGAAAUG UUAUGAAGCAGGGAUGA 9 73/372 TTGCATGCAAAAGAAAAAATCCCACATCCTGCTCA UUGCAUGCAAAAGAAAAAAUCCCACAUCCU LHAKEKIPHPAQDASTSSPSSWTPCSLLR AGACGCTTCTACCAGCTCACCAAGCTCCTGGACTC GCUCAAGACGCUUCUACCAGCUCACCAAGC ESCISSLLTC CGTGCAGCCTATTGCGAGAGAGCTGCATCAGTTC UCCUGGACUCCGUGCAGCCUAUUGCGAGA ACTTTTGACCTGCTAA GAGCUGCAUCAGUUCACUUUUGACCUGCU AA 10 74/373 CTGTGCAAGTGCCCAAGATCCTTTCTGGGAAAGTC CUGUGCAAGUGCCCAAGAUCCUUUCUGGGLC KCPRSFLGKSSPSISTPSEALETLFPHPS AAGCCCATCTATTTCCACACCCAGTGAAGCATTGG AAAGUCAAGCCCAUCUAUUUCCACACCCAG SCPLSDVFCLL AAACCCTATTTCCCCACCCCAGCTCATGCCCCCTTT UGAAGCAUUGGAAACCCUAUUUCCCCACCC CAGATGTCTTCTGCCTGTTATAA CAGCUCAUGCCCCCUUUCAGAUGUCUUCU GCCUGUUAUAA 11 75/374 ATGGTGTTGTATGCCTTTAAATCTGTGATGATCCT AUGGUGUUGUAUGCCUUUAAAUCUGUGA MVLYAFKSVMILIWPSVKLCLFTALLCAS CATATGGCCCAGTGTCAAGTTGTGCTTGTTTACAG UGAUCCUCAUAUGGCCCAGUGUCAAGUUG HTNVYLSYATGSLES CACTACTCTGTGCCAGCCACACAAACGTTTACTTA UGCUUGUUUACAGCACUACUCUGUGCCAG TCTTATGCCACGGGAAGTTTAGAGAGCTAA CCACACAAACGUUUACUUAUCUUAUGCCA CGGGAAGUUUAGAGAGCUAA 12 76/375 CTGGGGAAATCAAAACAAAAACAAGCAAACAAAA CUGGGGAAAUCAAAACAAAAACAAGCAAAC LGKSKQKQANKKKKQKQNKK AAAAAAAGCAAAAACAAAACAAAAAATAA AAAAAAAAAAAGCAAAAACAAAACAAAAAA UAA 13 77/376 GTGGAGCAATTCATTATACTGAAAATGTGCTTGTT GUGGAGCAAUUCAUUAUACUGAAAAUGU VEQFIILKMCLLLKICLHVNASPPNPFLSHS GTTGAAAATTTGTCTGCATGTTAATGCCTCACCCC GCUUGUUGUUGAAAAUUUGUCUGCAUGU LPPTSD CAAACCCTTTTCTCTCTCACTCTCTGCCTCCAACTTC UAAUGCCUCACCCCCAAACCCUUUUCUCUC AGATTGA UCACUCUCUGCCUCCAACUUCAGAUUGA 14 78/377 ATGTTCTCTTCAGCCAAAACTTGGCGACTTCCACA AUGUUCUCUUCAGCCAAAACUUGGCGACU MFSSAKTWRLPQKSLTTEKKESRDLTLCK GAAAAGTCTGACCACTGAGAAGAAGGAGAGCAG UCCACAGAAAAGUCUGACCACUGAGAAGA APFGSRSAFSCVSQGGAGARGEENDSLA AGATTTAACCCTTTGTAAGGCCCCATTTGGATCCA AGGAGAGCAGAGAUUUAACCCUUUGUAAG VLLLRTLTE GGTCTGCTTTCTCATGTGTGAGTCAGGGAGGAGC GCCCCAUUUGGAUCCAGGUCUGCUUUCUC TGGAGCCAGAGGAGAAGAAAATGATAGCTTGGCT AUGUGUGAGUCAGGGAGGAGCUGGAGCC GTTCTCCTGCTTAGGACACTGACTGAATAG AGAGGAGAAGAAAAUGAUAGCUUGGCUG UUCUCCUGCUUAGGACACUGACUGAAUAG 15 79/378 CTGCCAAACTCCGTGAAGCCACAAGCACCTTATGT CUGCCAAACUCCGUGAAGCCACAAGCACCU LPNSVKPQAPYVLPSVFCGPEFHHTAFQP CCTCCCTTCAGTGTTTTGTGGGCCTGAATTTCATCA UAUGUCCUCCCUUCAGUGUUUUGUGGGCC WSSSLFASFGHVHRFSVKSPHHQEG CACTGCATTTCAGCCATGGTCATCAAGCCTGTTTG UGAAUUUCAUCACACUGCAUUUCAGCCAU CTTCTTTTGGGCATGTTCACAGATTCTCTGTTAAGA GGUCAUCAAGCCUGUUUGCUUCUUUUGG GCCCCCACCACCAAGAAGGTTAG GCAUGUUCACAGAUUCUCUGUUAAGAGCC CCCACCACCAAGAAGGUUAG 16 80/379 GTGGGAAGAATGAAGGCACTAGAACCAGAAACC GUGGGAAGAAUGAAGGCACUAGAACCAGA VGRMKALEPETLQMLFLSPSISTCRSHEK CTGCAAATGCTCTTCTTGTCACCCAGCATATCCACC AACCCUGCAAAUGCUCUUCUUGUCACCCA REGTKRRL TGCAGAAGTCATGAGAAGAGAGAAGGAACAAAG GCAUAUCCACCUGCAGAAGUCAUGAGAAG AGGAGACTCTGA AGAGAAGGAACAAAGAGGAGACUCUGA 17 81/380 CTGACATTGCCCATACTCACTCAGATTCCCCACCTT CUGACAUUGCCCAUACUCACUCAGAUUCCC LTLPILTQIPHLCCCLLVRGRPNH TGTTGCTGCCTCTTAGTCAGAGGGAGGCCAAACC CACCUUUGUUGCUGCCUCUUAGUCAGAGG ATTGA GAGGCCAAACCAUUGA 18 82/381 ATGAGTAATATGCCAATCCAAGACTGCTGGAGAA AUGAGUAAUAUGCCAAUCCAAGACUGCUG MSNMPIQDCWRKLKLTGSLFGVG AACTAAAGCTGACAGGTTCCCTTTTTGGGGTGGG GAGAAAACUAAAGCUGACAGGUUCCCUUU ATAG UUGGGGUGGGAUAG 19 83/382 ATGTACAGGATCACTTTTAGCTGTTTTAAACAGAA AUGUACAGGAUCACUUUUAGCUGUUUUA MYRITFSCFKQKKISTTLFSYTRLHFNRSFT AAAAATATCCACCACTCTTTTCAGTTACACTAGGTT AACAGAAAAAAAUAUCCACCACUCUUUUCA SVLE ACATTTTAATAGGTCCTTTACATCTGTTTTGGAATG GUUACACUAGGUUACAUUUUAAUAGGUCC A UUUACAUCUGUUUUGGAAUGA 20 84/383 GTGATACACAGATTGAATTATATCATTTTCATATCT GUGAUACACAGAUUGAAUUAUAUCAUUU VIHRLNYIIFISLLVNTRSSPLHFSIKFFIFM CTCCTTGTAAATACTAGAAGCTCTCCTTTACATTTC UCAUAUCUCUCCUUGUAAAUACUAGAAGC GFPIVTLVFMNICFSFAKAKNQ TCTATCAAATTTTTCATCTTTATGGGTTTCCCAATT UCUCCUUUACAUUUCUCUAUCAAAUUUUU GTGACTCTTGTCTTCATGAATATATGTTTTTCATTT CAUCUUUAUGGGUUUCCCAAUUGUGACUC GCAAAAGCCAAAAATCAGTGA UUGUCUUCAUGAAUAUAUGUUUUUCAUU UGCAAAAGCCAAAAAUCAGUGA 21 85/384 ATGACAAAACTAGGGAAAAATAGCCTACACAAGC AUGACAAAACUAGGGAAAAAUAGCCUACA MTKLGKNSLHKPLGLLFLCLGLSEQRRF CTTTAGGCCTACTCTTTCTGTGCTTGGGTTTGAGTG CAAGCCUUUAGGCCUACUCUUUCUGUGCU AACAAAGGAGATTTTAG UGGGUUUGAGUGAACAAAGGAGAUUUUA G 22 86/385 CTGCTCTACAAACAGAGTTGGTATGGTTGGTATAC CUGCUCUACAAACAGAGUUGGUAUGGUUG LLYKQSWYGWYTVLTCEGLATQTHLAGE TGTACTCACCTGTGAGGGACTGGCCACTCAGACCC GUAUACUGUACUCACCUGUGAGGGACUGG LEDEDHSLEKSQGPSPNKLAVLDVDEE ACTTAGCTGGTGAGCTAGAAGATGAGGATCACTC CCACUCAGACCCACUUAGCUGGUGAGCUA ACTGGAAAAGTCACAAGGACCATCTCCAAACAAG GAAGAUGAGGAUCACUCACUGGAAAAGUC TTGGCAGTGCTCGATGTGGACGAAGAGTGA ACAAGGACCAUCUCCAAACAAGUUGGCAG UGCUCGAUGUGGACGAAGAGUGA 23 87/386 CTGTGCTGGGCAGCAGACAGCTGCCAGGATCACG CUGUGCUGGGCAGCAGACAGCUGCCAGGA LCWAADSCQDHELCSQRKESCGSFSSRSL AACTCTGTAGTCAAAGAAAAGAGTCGTGTGGCAG UCACGAACUCUGUAGUCAAAGAAAAGAGU GSSPRPSL TTTCAGCTCTCGTTCATTGGGCAGCTCGCCTAGGC CGUGUGGCAGUUUCAGCUCUCGUUCAUU CCAGCCTCTGA GGGCAGCUCGCCUAGGCCCAGCCUCUGA 24 88/387 CTGAGAAAGGGATATTTTGAAGGACTGTCATATA CUGAGAAAGGGAUAUUUUGAAGGACUGU LRKGYFEGLSYIFEKRKSVIHIFLCMFTGTK TCTTTGAAAAAAGAAAATCTGTAATACATATATTTT CAUAUAUCUUUGAAAAAAGAAAAUCUGUA KYRELHSVLWVVAEVIVQVEK TATGTATGTTCACTGGCACTAAAAAATATAGAGAG AUACAUAUAUUUUUAUGUAUGUUCACUG CTTCATTCTGTCCTTTGGGTAGTTGCTGAGGTAATT GCACUAAAAAAUAUAGAGAGCUUCAUUCU GTCCAGGTTGAAAAATAA GUCCUUUGGGUAGUUGCUGAGGUAAUUG UCCAGGUUGAAAAAUAA 25 89/388 CTGCCCCTTCCCAGCCCTGCACCAAAGCTGCATTT CUGCCCCUUCCCAGCCCUGCACCAAAGCUG LPLPSPAPKLHFRRLSPDSPVTTRAWPLH CAGGAGACTCTCTCCAGACAGCCCAGTAACTACCC CAUUUCAGGAGACUCUCUCCAGACAGCCCA SPGKIRG GAGCATGGCCCCTGCATAGCCCTGGAAAAATAAG GUAACUACCCGAGCAUGGCCCCUGCAUAGC AGGCTGA CCUGGAAAAAUAAGAGGCUGA 26 90/389 CTGTCTACGAATTATCTTGTGCCAGTTGCCCAGGT CUGUCUACGAAUUAUCUUGUGCCAGUUGC LSTNYLVPVAQVRGHWAKGVVFMFDPL GAGAGGGCACTGGGCCAAGGGAGTGGTTTTCAT CCAGGUGAGAGGGCACUGGGCCAAGGGAG QGVMGIRNAKAPDQIQNLKSK GTTTGACCCACTACAAGGGGTCATGGGAATCAGG UGGUUUUCAUGUUUGACCCACUACAAGGG AATGCCAAAGCACCAGATCAAATCCAAAACTTAAA GUCAUGGGAAUCAGGAAUGCCAAAGCACC GTCAAAATAA AGAUCAAAUCCAAAACUUAAAGUCAAAAU AA 27 91/390 GTGTGTGTGTGTGTTCTGATAGCTTTAACTTTCTCT GUGUGUGUGUGUGUUCUGAUAGCUUUAA VCVCVLIALTFSASLYLVPDHT GCATCTTTATATTTGGTTCCAGATCACACCTGA CUUUCUCUGCAUCUUUAUAUUUGGUUCC AGAUCACACCUGA 28 92/391 GTGAGAGAGGATGCAGTTTTGTTTTGGAAGCTCT GUGAGAGAGGAUGCAGUUUUGUUUUGGA VREDAVLFWKLSQNKQDTWIDQLTKSFL CTCAGAACAAACAAGACACCTGGATTGATCAGTTA AGCUCUCUCAGAACAAACAAGACACCUGGA PYWV ACTAAAAGTTTTCTCCCCTATTGGGTTTGA UUGAUCAGUUAACUAAAAGUUUUCUCCCC UAUUGGGUUUGA 29 93/392 GTGAAGGAGCAGAGGGATAAAAAGAGTAGAGGA GUGAAGGAGCAGAGGGAUAAAAAGAGUAG VKEQRDKKSRGHDTLYFTSSRQMNVESI CATGATACATTGTACTTTACTAGTTCAAGACAGAT AGGACAUGAUACAUUGUACUUUACUAGUU KTQWN GAATGTGGAAAGCATAAAAACTCAATGGAACTGA CAAGACAGAUGAAUGUGGAAAGCAUAAAA ACUCAAUGGAACUGA 30 94/393 CTGAGATTTACCACAGGGAAGGCCCAAACTTGGG CUGAGAUUUACCACAGGGAAGGCCCAAAC LRFTTGKAQTWGQKPTQVIDQWPPNGT GCCAAAAGCCTACCCAAGTGATTGACCAGTGGCC UUGGGGCCAAAAGCCUACCCAAGUGAUUG CCCTAATGGGACCTGA ACCAGUGGCCCCCUAAUGGGACCUGA 31 95/394 CTGTTCCTTGGTCTTCACCATCCTTGTGAGAGAAG CUGUUCCUUGGUCUUCACCAUCCUUGUGA LFLGLHHPCERRAVSCIGTWSKRSIFHTNS GGCAGTTTCCTGCATTGGAACCTGGAGCAAGCGC GAGAAGGGCAGUUUCCUGCAUUGGAACCULT TCTATCTTTCACACAAATTCCCTCACCTGA GGAGCAAGCGCUCUAUCUUUCACACAAAU UCCCUCACCUGA 32 96/395 CTGATTCCAATTCAGTATAGCAAGGTGCTAGGTTT CUGAUUCCAAUUCAGUAUAGCAAGGUGCU LIPIQYSKVLGFFLSPPVS TTTCCTTTCCCCACCTGTCTCTTAG AGGUUUUUUCCUUUCCCCACCUGUCUCUU AG 33 97/396 CTGGTGGTTCCCTCTCTGGCTGCTGCCTCACAGTA CUGGUGGUUCCCUCUCUGGCUGCUGCCUC LVVPSLAAASQYGNLYSAEVTGQICIISQP TGGGAACCTGTACTCTGCAGAGGTGACAGGCCAG ACAGUAUGGGAACCUGUACUCUGCAGAGG ATTTGCATTATCTCACAACCTTAG UGACAGGCCAGAUUUGCAUUAUCUCACAA CCUUAG 34 98/397 TTGCTTGAAATCTCTTTAGATGGGGCTCATTTCTCA UUGCUUGAAAUCUCUUUAGAUGGGGCUC LLEISLDGAHFSRWHLASTGQQDQLQAL CGGTGGCACTTGGCCTCCACTGGGCAGCAGGACC AUUUCUCACGGUGGCACUUGGCCUCCACU VFCSLFVILESFVALNTIKNGRNLFVGLHV AGCTCCAAGCGCTAGTGTTCTGTTCTCTTTTTGTAA GGGCAGCAGGACCAGCUCCAAGCGCUAGU TCTTGGAATCTTTTGTTGCTCTAAATACAATTAAAA GUUCUGUUCUCUUUUUGUAAUCUUGGAA ATGGCAGAAACTTGTTTGTTGGACTACATGTGTGA UCUUUUGUUGCUCUAAAUACAAUUAAAAA UGGCAGAAACUUGUUUGUUGGACUACAU GUGUGA 35 99/398 GTGAGCCTAGCAGGGCAGATCTTGTCCACCGTGT GUGAGCCUAGCAGGGCAGAUCUUGUCCAC VSLAGQILSTVCLLLHETLRLSERFLRGCSR GTCTTCTTCTGCACGAGACTTTGAGGCTGTCAGAG CGUGUGUCUUCUUCUGCACGAGACUUUGA KFPSLELPAGGQLAAATTASSQPVELF CGCTTTTTGCGTGGTTGCTCCCGCAAGTTTCCTTCT GGCUGUCAGAGCGCUUUUUGCGUGGUUG CTGGAGCTTCCCGCAGGTGGGCAGCTAGCTGCAG CUCCCGCAAGUUUCCUUCUCUGGAGCUUC CGACTACCGCATCATCACAGCCTGTTGAACTCTTC CCGCAGGUGGGCAGCUAGCUGCAGCGACU TGA ACCGCAUCAUCACAGCCUGUUGAACUCUU CUGA 36 100/399 GTGGAAGATTCAGCCAAGCTCAAGGATGGAAGTG GUGGAAGAUUCAGCCAAGCUCAAGGAUGG VEDSAKLKDGSAVRAGKGLPSAAVQDLP CAGTTAGGGCTGGGAAGGGTCTACCCTCGGCCGC AAGUGCAGUUAGGGCUGGGAAGGGUCUA RSFPESVPERARSDPEPGPQAPRGRERST CGTCCAAGACCTACCGAGGAGCTTTCCAGAATCTG CCCUCGGCCGCCGUCCAAGACCUACCGAGG SRRQFAAAAAAAAAAAAAAAAAAAAAA TTCCAGAGCGTGCGCGAAGTGATCCAGAACCCGG AGCUUUCCAGAAUCUGUUCCAGAGCGUGC AAAARD GCCCCAGGCACCCAGAGGCCGCGAGCGCAGCACC GCGAAGUGAUCCAGAACCCGGGCCCCAGGC TCCCGGCGCCAGTTTGCTGCTGCTGCAGCAGCAG ACCCAGAGGCCGCGAGCGCAGCACCUCCCG CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG GCGCCAGUUUGCUGCUGCUGCAGCAGCAG CAGCAGCAGCAGCAGCAGCAGCAGCAAGAGACT CAGCAGCAGCAGCAGCAGCAGCAGCAGCAG AG CAGCAGCAGCAGCAGCAGCAGCAGCAGCAA GAGACUAG 37 101/400 GTGCCACCCCGAGAGAGGTTGCGTCCCAGAGCCT GUGCCACCCCGAGAGAGGUUGCGUCCCAG VPPRERLRPRAWSRRGRQQGAAAAAAS GGAGCCGCCGTGGCCGCCAGCAAGGGGCTGCCG AGCCUGGAGCCGCCGUGGCCGCCAGCAAG TSGRG CAGCAGCTGCCAGCACCTCCGGACGAGGATGA GGGCUGCCGCAGCAGCUGCCAGCACCUCCG GACGAGGAUGA 38 102/401 TTGCATGTACGCCCCACTTTTGGGAGTTCCACCCG UUGCAUGUACGCCCCACUUUUGGGAGUUC LHVRPTFGSSTRCASHSLCPIGRMQRFSA CTGTGCGTCCCACTCCTTGTGCCCCATTGGCCGAA CACCCGCUGUGCGUCCCACUCCUUGUGCCC RRQRRQEH TGCAAAGGTTCTCTGCTAGACGACAGCGCAGGCA CAUUGGCCGAAUGCAAAGGUUCUCUGCUA AGAGCACTGA GACGACAGCGCAGGCAAGAGCACUGA 39 103/402 CTGGGCGGCTGCGGCGGCGCAGTGCCGCTATGG CUGGGCGGCUGCGGCGGCGCAGUGCCGCU LGGCGGAVPLWGPGEPAWRGCSGTRF GGACCTGGCGAGCCTGCATGGCGCGGGTGCAGC AUGGGGACCUGGCGAGCCUGCAUGGCGCG WVTLSRRFLILAHSLHSRRRPVVWTVW GGGACCCGGTTCTGGGTCACCCTCAGCCGCCGCTT GGUGCAGCGGGACCCGGUUCUGGGUCACC WWWGWWRRRRRRRRRRRRRRRRRG CCTCATCCTGGCACACTCTCTTCACAGCCGAAGAA CUCAGCCGCCGCUUCCUCAUCCUGGCACAC GSCSPLRLHSAPSGAGGPGKRLHRT GGCCAGTTGTATGGACCGTGTGGTGGTGGTGGG UCUCUUCACAGCCGAAGAAGGCCAGUUGU GGTGGTGGCGGCGGCGGCGGCGGCGGCGGCGG AUGGACCGUGUGGUGGUGGUGGGGGUGG CGGCGGCGGCGGCGGCGGCGGCGGCGAGGCGG UGGCGGCGGCGGCGGCGGCGGCGGCGGCG GAGCTGTAGCCCCCTACGGCTACACTCGGCCCCCT GCGGCGGCGGCGGCGGCGGCGGCGAGGCG CAGGGGCTGGCGGGCCAGGAAAGCGACTTCACC GGAGCUGUAGCCCCCUACGGCUACACUCG GCACCTGA GCCCCCUCAGGGGCUGGCGGGCCAGGAAA GCGACUUCACCGCACCUGA 40 104/403 GTGGTACCCTGGCGGCATGGTGAGCAGAGTGCCC GUGGUACCCUGGCGGCAUGGUGAGCAGAG VVPWRHGEQSALSQSHLCQKRNGPLDG TATCCCAGTCCCACTTGTGTCAAAAGCGAAATGGG UGCCCUAUCCCAGUCCCACUUGUGUCAAA CCCCTGGATGGATAG AGCGAAAUGGGCCCCUGGAUGGAUAG 41 105/404 GTGTCACTATGGAGCTCTCACATGTGGAAGCTGC GUGUCACUAUGGAGCUCUCACAUGUGGAA VSLWSSHMWKLQGLLQKSR AAGGTCTTCTTCAAAAGAGCCGCTGA GCUGCAAGGUCUUCUUCAAAAGAGCCGCU GA 42 106/405 GTGGGCCAAGGCCTTGCCTGGCTTCCGCAACTTAC GUGGGCCAAGGCCUUGCCUGGCUUCCGCA VGQGLAWLPQLTRGRPDGCHSVLLDGA ACGTGGACGACCAGATGGCTGTCATTCAGTACTCC ACUUACACGUGGACGACCAGAUGGCUGUC HGVCHGLAILHQCQLQDALLRP TGGATGGGGCTCATGGTGTTTGCCATGGGCTGGC AUUCAGUACUCCUGGAUGGGGCUCAUGGU GATCCTTCACCAATGTCAACTCCAGGATGCTCTAC GUUUGCCAUGGGCUGGCGAUCCUUCACCA TTCGCCCCTGA AUGUCAACUCCAGGAUGCUCUACUUCGCC CCUGA 43 107/406 GTGTGTCCGAATGAGGCACCTCTCTCAAGAGTTTG GUGUGUCCGAAUGAGGCACCUCUCUCAAG VCPNEAPLSRVWMAPNHPPGIPVHEST GATGGCTCCAAATCACCCCCCAGGAATTCCTGTGC AGUUUGGAUGGCUCCAAAUCACCCCCCAG ATLQHYSSGWAEKSKIL ATGAAAGCACTGCTACTCTTCAGCATTATTCCAGT GAAUUCCUGUGCAUGAAAGCACUGCUACU GGATGGGCTGAAAAATCAAAAATTCTTTGA CUUCAGCAUUAUUCCAGUGGAUGGGCUGA AAAAUCAAAAAUUCUUUGA 44 108/407 ATGCAAAAGAAAAAATCCCACATCCTGCTCAAGAC AUGCAAAAGAAAAAAUCCCACAUCCUGCUC MQKKKSHILLKTLLPAHQAPGLRAAYCER GCTTCTACCAGCTCACCAAGCTCCTGGACTCCGTG AAGACGCUUCUACCAGCUCACCAAGCUCCU AASVHF CAGCCTATTGCGAGAGAGCTGCATCAGTTCACTTT GGACUCCGUGCAGCCUAUUGCGAGAGAGC TGA UGCAUCAGUUCACUUUUGA 45 109/408 GTGAAGCATTGGAAACCCTATTTCCCCACCCCAGC GUGAAGCAUUGGAAACCCUAUUUCCCCAC VKHWKPYFPTPAHAPFQMSSACYNSALL TCATGCCCCCTTTCAGATGTCTTCTGCCTGTTATAA CCCAGCUCAUGCCCCCUUUCAGAUGUCUUC LCSALGNFLY CTCTGCACTACTCCTCTGCAGTGCCTTGGGGAATT UGCCUGUUAUAACUCUGCACUACUCCUCU TCCTCTATTGA GCAGUGCCUUGGGGAAUUUCCUCUAUUGA 46 110/409 TTGCTGGGCTTTTTTTTTCTCTTTCTCTCCTTTCTTTT UUGCUGGGCUUUUUUUUUCUCUUUCUCU LLGFFFLFLSFLFLLPSLSNPPMAPSDFASH TCTTCTTCCCTCCCTATCTAACCCTCCCATGGCACC CCUUUCUUUUUCUUCUUCCCUCCCUAUCU CGSYLCFEWCCMPLNL TTCAGACTTTGCTTCCCATTGTGGCTCCTATCTGTG AACCCUCCCAUGGCACCUUCAGACUUUGCU TTTTGAATGGTGTTGTATGCCTTTAAATCTGTGA UCCCAUUGUGGCUCCUAUCUGUGUUUUG AAUGGUGUUGUAUGCCUUUAAAUCUGUG A 47 111/410 GTGTCAAGTTGTGCTTGTTTACAGCACTACTCTGT GUGUCAAGUUGUGCUUGUUUACAGCACU VSSCACLQHYSVPATQTFTYLMPREV GCCAGCCACACAAACGTTTACTTATCTTATGCCAC ACUCUGUGCCAGCCACACAAACGUUUACU GGGAAGTTTAG UAUCUUAUGCCACGGGAAGUUUAG 48 112/411 GTGAAAATTGCAGGCCCATGGGGAGTTACTGATT GUGAAAAUUGCAGGCCCAUGGGGAGUUAC VKIAGPWGVTDFFISSLHGRLYFLPMAIAI TTTTCATCTCCTCCCTCCACGGGAGACTTTATTTTC UGAUUUUUUCAUCUCCUCCCUCCACGGGA RGQSDPRAELGRGVDREERTRRAMEHQ TGCCAATGGCTATTGCCATTAGAGGGCAGAGTGA GACUUUAUUUUCUGCCAAUGGCUAUUGCC YLPTALVPGG CCCCAGAGCTGAGTTGGGCAGGGGGGTGGACAG AUUAGAGGGCAGAGUGACCCCAGAGCUGA AGAGGAGAGGACAAGGAGGGCAATGGAGCATCA GUUGGGCAGGGGGGUGGACAGAGAGGAG GTACCTGCCCACAGCCTTGGTCCCTGGGGGCTAG AGGACAAGGAGGGCAAUGGAGCAUCAGUA CCUGCCCACAGCCUUGGUCCCUGGGGGCU AG 49 113/412 ATGTTAATGCCTCACCCCCAAACCCTTTTCTCTCTC AUGUUAAUGCCUCACCCCCAAACCCUUUUC MLMPHPQTLFSLTLCLQLQIDFQ ACTCTCTGCCTCCAACTTCAGATTGACTTTCAATAG UCUCUCACUCUCUGCCUCCAACUUCAGAU UGACUUUCAAUAG 50 114/413 ATGTCCTCCCTTCAGTGTTTTGTGGGCCTGAATTTC AUGUCCUCCCUUCAGUGUUUUGUGGGCCU MSSLQCFVGLNFITLHFSHGHQACLLLLG ATCACACTGCATTTCAGCCATGGTCATCAAGCCTG GAAUUUCAUCACACUGCAUUUCAGCCAUG MFTDSLLRAPTTKKVSRPTALTSICRCQ TTTGCTTCTTTTGGGCATGTTCACAGATTCTCTGTT GUCAUCAAGCCUGUUUGCUUCUUUUGGG AAGAGCCCCCACCACCAAGAAGGTTAGCAGGCCA CAUGUUCACAGAUUCUCUGUUAAGAGCCC ACAGCTCTGACATCTATCTGTAGATGCCAGTAG CCACCACCAAGAAGGUUAGCAGGCCAACAG CUCUGACAUCUAUCUGUAGAUGCCAGUAG 51 115/414 CTGGGCGTCTTGCCCTTGTCCCCCAGAGATGATAC CUGGGCGUCUUGCCCUUGUCCCCCAGAGA LGVLPLSPRDDTLPASGEVLTSFFRAAKG CCTCCCAGCAAGTGGAGAAGTTCTCACTTCCTTCT UGAUACCCUCCCAGCAAGUGGAGAAGUUC ATQIRVEEKTQLPGWEE TTAGAGCAGCTAAAGGGGCTACCCAGATCAGGGT UCACUUCCUUCUUUAGAGCAGCUAAAGGG TGAAGAGAAAACTCAATTACCAGGGTGGGAAGAA GCUACCCAGAUCAGGGUUGAAGAGAAAAC TGA UCAAUUACCAGGGUGGGAAGAAUGA 52 116/415 ATGGCTTCTTTCGGAAAGGTCTGGTTGGTGTGGCT AUGGCUUCUUUCGGAAAGGUCUGGUUGG MASFGKVWLVWLQYFATHELRVCPGTL CCAATACTTTGCCACCCATGAACTCAGGGTGTGCC UGUGGCUCCAAUACUUUGCCACCCAUGAA VLYSLLAHLCSVDFVLQAQVQGKMSTYFL CTGGGACACTGGTTTTATATAGTCTTTTGGCACAC CUCAGGGUGUGCCCUGGGACACUGGUUUU ILASASLLSS CTGTGTTCTGTTGACTTCGTTCTTCAAGCCCAAGTG AUAUAGUCUUUUGGCACACCUGUGUUCU CAAGGGAAAATGTCCACCTACTTTCTCATCTTGGC GUUGACUUCGUUCUUCAAGCCCAAGUGCA CTCTGCCTCCTTACTTAGCTCTTAA AGGGAAAAUGUCCACCUACUUUCUCAUCU UGGCCUCUGCCUCCUUACUUAGCUCUUAA 53 117/416 CTGTTGAACTCAAGAAATCAAGGGCCAGTCATCA CUGUUGAACUCAAGAAAUCAAGGGCCAGU LLNSRNQGPVIKLPILIDSLCLLRG AGCTGCCCATTTTAATTGATTCACTCTGTTTGTTGA CAUCAAGCUGCCCAUUUUAAUUGAUUCAC GAGGATAG UCUGUUUGUUGAGAGGAUAG 54 118/417 TTGGGGTGGGATAGACATGTTCTGGTTTTCTTTAT UUGGGGUGGGAUAGACAUGUUCUGGUUU LGWDRHVLVFFIITQSGSCTGSLLAVLNR TATTACACAATCTGGCTCATGTACAGGATCACTTTT UCUUUAUUAUUACACAAUCUGGCUCAUGU KKYPPLFSVTLGYILIGPLHLFWNDFHLL AGCTGTTTTAAACAGAAAAAAATATCCACCACTCT ACAGGAUCACUUUUAGCUGUUUUAAACAG TTTCAGTTACACTAGGTTACATTTTAATAGGTCCTT AAAAAAAUAUCCACCACUCUUUUCAGUUA TACATCTGTTTTGGAATGATTTTCATCTTTTGTGA CACUAGGUUACAUUUUAAUAGGUCCUUUA CAUCUGUUUUGGAAUGAUUUUCAUCUUU UGUGA 55 119/418 TTGGCCATTGATGTTCTAGCCAATGTAATTGACAG UUGGCCAUUGAUGUUCUAGCCAAUGUAAU LAIDVLANVIDRSLILHALCSTNRVGMVGI AAGTCTCATTTTGCATGCGCTCTGCTCTACAAACA UGACAGAAGUCUCAUUUUGCAUGCGCUCU LYSPVRDWPLRPT GAGTTGGTATGGTTGGTATACTGTACTCACCTGTG GCUCUACAAACAGAGUUGGUAUGGUUGG AGGGACTGGCCACTCAGACCCACTTAG UAUACUGUACUCACCUGUGAGGGACUGGC CACUCAGACCCACUUAG 56 120/419 TTGTCCAGGTTGAAAAATAATGTGCTGATGCTAGA UUGUCCAGGUUGAAAAAUAAUGUGCUGA LSRLKNNVLMLESLSVHTLLLNTYRHT GTCCCTCTCTGTCCATACTCTACTTCTAAATACATA UGCUAGAGUCCCUCUCUGUCCAUACUCUA TAGGCATACATAG CUUCUAAAUACAUAUAGGCAUACAUAG 57 121/420 CTGGCAGGGCATAAAGGCCCAGGCCACTTCCTCT CUGGCAGGGCAUAAAGGCCCAGGCCACUU LAGHKGPGHFLCPFPALHQSCISGDSLQT GCCCCTTCCCAGCCCTGCACCAAAGCTGCATTTCA CCUCUGCCCCUUCCCAGCCCUGCACCAAAG AQ GGAGACTCTCTCCAGACAGCCCAGTAA CUGCAUUUCAGGAGACUCUCUCCAGACAG CCCAGUAA 58 122/421 TTGACCCACTACAAGGGGTCATGGGAATCAGGAA UUGACCCACUACAAGGGGUCAUGGGAAUC LTHYKGSWESGMPKHQIKSKT TGCCAAAGCACCAGATCAAATCCAAAACTTAA AGGAAUGCCAAAGCACCAGAUCAAAUCCAA AACUUAA 59 123/422 ATGTTCAGTTTCTTGGAAAAGGAAGTTTCTACCCC AUGUUCAGUUUCUUGGAAAAGGAAGUUU MFSFLEKEVSTPDAFVGRSVLTINLFENLL TGATGCCTTTGTAGGCAGATCTGTTCTCACCATTA CUACCCCUGAUGCCUUUGUAGGCAGAUCU KQFLKREMKASHYITKDYIVPAKIPKFIRA ATCTTTTTGAAAATCTTTTAAAGCAGTTTTTAAAAA GUUCUCACCAUUAAUCUUUUUGAAAAUCU GGEQALVPL GAGAGATGAAAGCATCACATTATATAACCAAAGA UUUAAAGCAGUUUUUAAAAAGAGAGAUG TTACATTGTACCTGCTAAGATACCAAAATTCATAA AAAGCAUCACAUUAUAUAACCAAAGAUUA GGGCAGGGGGGGAGCAAGCATTAGTGCCTCTTTG CAUUGUACCUGCUAAGAUACCAAAAUUCA A UAAGGGCAGGGGGGGAGCAAGCAUUAGU GCCUCUUUGA 60 124/423 TTGCTGAGCAAATTGTTGAAGCTCCATCATTGCAT UUGCUGAGCAAAUUGUUGAAGCUCCAUCA LLSKLLKLHHCMVGNGAVLSHCVC GGTTGGAAATGGAGCTGTTCTTAGCCACTGTGTTT UUGCAUGGUUGGAAAUGGAGCUGUUCUU GCTAG AGCCACUGUGUUUGCUAG 61 125/424 TTGAAATACATTGTAAATGAATATTTGTATCCATG UUGAAAUACAUUGUAAAUGAAUAUUUGU LKYIVNEYLYPCFKIEIYIYIYIYIYIYI TTTCAAAATTGAAATATATATATATATATATATATA AUCCAUGUUUCAAAAUUGAAAUAUAUAUA TATATATATATATATATAG UAUAUAUAUAUAUAUAUAUAUAUAUAUA UAUAG 62 126/425 ATGCAGTTTTGTTTTGGAAGCTCTCTCAGAACAAA AUGCAGUUUUGUUUUGGAAGCUCUCUCA MQFCFGSSLRTNKTPGLIS CAAGACACCTGGATTGATCAGTTAA GAACAAACAAGACACCUGGAUUGAUCAGU UAA 63 127/426 TTGACCAGTGGCCCCCTAATGGGACCTGAGCTGTT UUGACCAGUGGCCCCCUAAUGGGACCUGA LTSGPLMGPELLEEENCSLVFTILVREGQF GGAAGAAGAGAACTGTTCCTTGGTCTTCACCATCC GCUGUUGGAAGAAGAGAACUGUUCCUUG PALEPGASALSFTQIPSPEIEVLLLLGVCVL TTGTGAGAGAAGGGCAGTTTCCTGCATTGGAACC GUCUUCACCAUCCUUGUGAGAGAAGGGCA TGGAGCAAGCGCTCTATCTTTCACACAAATTCCCT GUUUCCUGCAUUGGAACCUGGAGCAAGCG CACCTGAGATTGAGGTGCTCTTGTTACTGGGTGTC CUCUAUCUUUCACACAAAUUCCCUCACCUG TGTGTGCTGTAA AGAUUGAGGUGCUCUUGUUACUGGGUGU CUGUGUGCUGUAA 64 128/427 TTGACAAATGAAAATGTGTTTTTCTCTGTTAAAACT UUGACAAAUGAAAAUGUGUUUUUCUCUG LTNENVFFSVKTCQSTRSCISVGAGPFLPT TGTCAGAGTACTAGAAGTTGTATCTCTGTAGGTGC UUAAAACUUGUCAGAGUACUAGAAGUUG GRVFFFD AGGTCCATTTCTGCCCACAGGTAGGGTGTTTTTCT UAUCUCUGUAGGUGCAGGUCCAUUUCUGC TTGATTAA CCACAGGUAGGGUGUUUUUCUUUGAUUA A 65 129/428 ATGAGAAGCCTTAGAATGGGTGGCCCTTGTGACC AUGAGAAGCCUUAGAAUGGGUGGCCCUUG MRSLRMGGPCDLKHFPHKLLNKIVMEL TGAAACACTTCCCACATAAGCTACTTAACAAGATT UGACCUGAAACACUUCCCACAUAAGCUACU QIPLPTKD GTCATGGAGCTGCAGATTCCATTGCCCACCAAAGA UAACAAGAUUGUCAUGGAGCUGCAGAUUC CTAG CAUUGCCCACCAAAGACUAG 66 130/429 ATGCTGTTTCTCTGGTGGTTCCCTCTCTGGCTGCTG AUGCUGUUUCUCUGGUGGUUCCCUCUCU MLFLWWFPLWLLPHSMGTCTLQR CCTCACAGTATGGGAACCTGTACTCTGCAGAGGT GGCUGCUGCCUCACAGUAUGGGAACCUGU GA ACUCUGCAGAGGUGA 67 131/430 CTGTCCTACAGTGAAGTGCCTGGGGGGTTGTCCT CUGUCCUACAGUGAAGUGCCUGGGGGGU LSYSEVPGGLSYPISHLDADSSHHQNDPR ATCCCATAAGCCACTTGGATGCTGACAGCAGCCAC UGUCCUAUCCCAUAAGCCACUUGGAUGCU KKKKKKIKKSPHNPVTPFCFPLDWNID CATCAGAATGACCCACGCAAAAAAAAGAAAAAAA GACAGCAGCCACCAUCAGAAUGACCCACGC AAATTAAAAAGTCCCCTCACAACCCAGTGACACCT AAAAAAAAGAAAAAAAAAAUUAAAAAGUCC TTCTGCTTTCCTCTAGACTGGAACATTGATTAG CCUCACAACCCAGUGACACCUUUCUGCUUU CCUCUAGACUGGAACAUUGAUUAG 68 132/431 ATGGGGCTCATTTCTCACGGTGGCACTTGGCCTCC AUGGGGCUCAUUUCUCACGGUGGCACUUG MGLISHGGTWPPLGSRTSSKR ACTGGGCAGCAGGACCAGCTCCAAGCGCTAG GCCUCCACUGGGCAGCAGGACCAGCUCCAA GCGCUAG 69 133/432 ATGGCAGAAACTTGTTTGTTGGACTACATGTGTGA AUGGCAGAAACUUGUUUGUUGGACUACA MAETCLLDYMCDFGSVSASAFRNVIHCV CTTTGGGTCTGTCTCTGCCTCTGCTTTCAGAAATGT UGUGUGACUUUGGGUCUGUCUCUGCCUC KYWLTGLPAKTWPHPLLWLQDRVIVNKE CATCCATTGTGTAAAATATTGGCTTACTGGTCTGC UGCUUUCAGAAAUGUCAUCCAUUGUGUAA TQEKLLMSSYHCC CAGCTAAAACTTGGCCACATCCCCTGTTATGGCTG AAUAUUGGCUUACUGGUCUGCCAGCUAAA CAGGATCGAGTTATTGTTAACAAAGAGACCCAAG ACUUGGCCACAUCCCCUGUUAUGGCUGCA AAAAGCTGCTAATGTCCTCTTATCATTGTTGTTAA GGAUCGAGUUAUUGUUAACAAAGAGACCC AAGAAAAGCUGCUAAUGUCCUCUUAUCAU UGUUGUUAA 70 134/433 CTGTTTTCCCCCACTCTCTCTCCACCTCCTCCTGCCT CUGUUUUCCCCCACUCUCUCUCCACCUCCU LFSPTLSPPPPAFPTPSAEPEIKR TCCCCACCCCGAGTGCGGAGCCAGAGATCAAAAG CCUGCCUUCCCCACCCCGAGUGCGGAGCCA ATGA GAGAUCAAAAGAUGA 71 135/434 GTGGACACTGAATTTGGAAGGTGGAGGATTTTGT GUGGACACUGAAUUUGGAAGGUGGAGGA VDTEFGRWRILFFSFKIWASFESTLQVLR TTTTTTCTTTTAAGATCTGGGCATCTTTTGAATCTA UUUUGUUUUUUUCUUUUAAGAUCUGGGC DRL CCCTTCAAGTATTAAGAGACAGACTGTGA AUCUUUUGAAUCUACCCUUCAAGUAUUAA GAGACAGACUGUGA 72 136/435 ATGGCCCAGTGTCAAGTTGTGCTTGTTTACAGCAC AUGGCCCAGUGUCAAGUUGUGCUUGUUU MAQCQVVLVYSTTLCQPHKRLLILCHGKF TACTCTGTGCCAGCCACACAAACGTTTACTTATCTT ACAGCACUACUCUGUGCCAGCCACACAAAC RELRLSGEIKTKTSKQKKKAKTKQKISQKT ATGCCACGGGAAGTTTAGAGAGCTAAGATTATCT GUUUACUUAUCUUAUGCCACGGGAAGUU LLVFFPQK GGGGAAATCAAAACAAAAACAAGCAAACAAAAA UAGAGAGCUAAGAUUAUCUGGGGAAAUCA AAAAAAGCAAAAACAAAACAAAAAATAAGCCAAA AAACAAAAACAAGCAAACAAAAAAAAAAAG AAACCTTGCTAGTGTTTTTTCCTCAAAAATAA CAAAAACAAAACAAAAAAUAAGCCAAAAAA CCUUGCUAGUGUUUUUUCCUCAAAAAUAA 73 137/436 TTGACTTTCAATAGTTTTTCTAAGACCTTTGAACTG UUGACUUUCAAUAGUUUUUCUAAGACCU LTFNSFSKTFELNVLFSQNLATSTEKSDH AATGTTCTCTTCAGCCAAAACTTGGCGACTTCCAC UUGAACUGAAUGUUCUCUUCAGCCAAAAC AGAAAAGTCTGACCACTGA UUGGCGACUUCCACAGAAAAGUCUGACCA CUGA 74 138/437 ATGAAGTTTTCTGCCAAACTCCGTGAAGCCACAAG AUGAAGUUUUCUGCCAAACUCCGUGAAGC MKFSAKLREATSTLCPPFSVLWA CACCTTATGTCCTCCCTTCAGTGTTTTGTGGGCCTG CACAAGCACCUUAUGUCCUCCCUUCAGUG A UUUUGUGGGCCUGA 75 139/438 CTGCTGGAGAAAACTAAAGCTGACAGGTTCCCTTT CUGCUGGAGAAAACUAAAGCUGACAGGUU LLEKTKADRFPFWGGIDMFWFSLLLHNL TTGGGGTGGGATAGACATGTTCTGGTTTTCTTTAT CCCUUUUUGGGGUGGGAUAGACAUGUUC AHVQDHF TATTACACAATCTGGCTCATGTACAGGATCACTTTT UGGUUUUCUUUAUUAUUACACAAUCUGG AG CUCAUGUACAGGAUCACUUUUAG 76 140/439 ATGATTTTCATCTTTTGTGATACACAGATTGAATTA AUGAUUUUCAUCUUUUGUGAUACACAGA MIFIFCDTQIELYHFHISPCKY TATCATTTTCATATCTCTCCTTGTAAATACTAG UUGAAUUAUAUCAUUUUCAUAUCUCUCCU UGUAAAUACUAG 77 141/440 TTGACAGAAGTCTCATTTTGCATGCGCTCTGCTCT UUGACAGAAGUCUCAUUUUGCAUGCGCUC LTEVSFCMRSALQTELVWLVYCTHL ACAAACAGAGTTGGTATGGTTGGTATACTGTACTC UGCUCUACAAACAGAGUUGGUAUGGUUG ACCTGTGA GUAUACUGUACUCACCUGUGA 78 142/441 GTGAGGAAGAGAAAAAGAAGGAGCACCAGGGA GUGAGGAAGAGAAAAAGAAGGAGCACCAG VRKRKRRSTREKAPSVLGSRQLPGSRTL GAAGGCTCCGTCTGTGCTGGGCAGCAGACAGCTG GGAGAAGGCUCCGUCUGUGCUGGGCAGCA CCAGGATCACGAACTCTGTAG GACAGCUGCCAGGAUCACGAACUCUGUAG 79 143/442 CTGACTGTCTACGAATTATCTTGTGCCAGTTGCCC CUGACUGUCUACGAAUUAUCUUGUGCCAG LTVYELSCASCPGERALGQGSGFHV AGGTGAGAGGGCACTGGGCCAAGGGAGTGGTTT UUGCCCAGGUGAGAGGGCACUGGGCCAAG TCATGTTTGA GGAGUGGUUUUCAUGUUUGA 80 144/443 TTGTGGGTTTTTTTTTCCCTAATAATATACATGTTT UUGUGGGUUUUUUUUUCCCUAAUAAUAU LWVFFSLIIYMFRRIENNFGKMGLWVLH AGAAGAATTGAAAATAATTTCGGGAAAATGGGAT ACAUGUUUAGAAGAAUUGAAAAUAAUUUC TATGGGTCCTTCACTAA GGGAAAAUGGGAUUAUGGGUCCUUCACU AA 81 145/444 TTGGAAATGGAGCTGTTCTTAGCCACTGTGTTTGC UUGGAAAUGGAGCUGUUCUUAGCCACUG LEMELFLATVFASAHVSLSEDVKPLLIREH TAGTGCCCATGTTAGCTTATCTGAAGATGTGAAAC UGUUUGCUAGUGCCCAUGUUAGCUUAUC LKY CCTTGCTGATAAGGGAGCATTTAAAGTACTAG UGAAGAUGUGAAACCCUUGCUGAUAAGGG AGCAUUUAAAGUACUAG 82 146/445 ATGAATATTTGTATCCATGTTTCAAAATTGAAATAT AUGAAUAUUUGUAUCCAUGUUUCAAAAU MNICIHVSKLKYIYIYIYIYIYIYSVCVCSDSF ATATATATATATATATATATATATATATATATATAT UGAAAUAUAUAUAUAUAUAUAUAUAUAU NFLCIFIFGSRSHLMPCTCERGCSFVLEAL AGTGTGTGTGTGTGTTCTGATAGCTTTAACTTTCTC AUAUAUAUAUAUAUAUAGUGUGUGUGUG SEQTRHLD TGCATCTTTATATTTGGTTCCAGATCACACCTGATG UGUUCUGAUAGCUUUAACUUUCUCUGCA CCATGTACTTGTGAGAGAGGATGCAGTTTTGTTTT UCUUUAUAUUUGGUUCCAGAUCACACCUG GGAAGCTCTCTCAGAACAAACAAGACACCTGGAT AUGCCAUGUACUUGUGAGAGAGGAUGCAG TGA UUUUGUUUUGGAAGCUCUCUCAGAACAAA CAAGACACCUGGAUUGA 83 147/446 ATGGAACTGACTGAGATTTACCACAGGGAAGGCC AUGGAACUGACUGAGAUUUACCACAGGGA MELTEIYHREGPNLGPKAYPSD CAAACTTGGGGCCAAAAGCCTACCCAAGTGATTG AGGCCCAAACUUGGGGCCAAAAGCCUACCC A AAGUGAUUGA 84 148/447 CTGCATTGGAACCTGGAGCAAGCGCTCTATCTTTC CUGCAUUGGAACCUGGAGCAAGCGCUCUA LHWNLEQALYLSHKFPHLRLRCSCYWVS ACACAAATTCCCTCACCTGAGATTGAGGTGCTCTT UCUUUCACACAAAUUCCCUCACCUGAGAU VCCNSGFGYVL GTTACTGGGTGTCTGTGTGCTGTAATTCTGGTTTT UGAGGUGCUCUUGUUACUGGGUGUCUGU GGATATGTTCTGTAA GUGCUGUAAUUCUGGUUUUGGAUAUGUU CUGUAA 85 149/448 ATGAAAATGTGTTTTTCTCTGTTAAAACTTGTCAG AUGAAAAUGUGUUUUUCUCUGUUAAAAC MKMCFSLLKLVRVLEVVSL AGTACTAGAAGTTGTATCTCTGTAG UUGUCAGAGUACUAGAAGUUGUAUCUCU GUAG 86 150/449 GTGCAGGTCCATTTCTGCCCACAGGTAGGGTGTTT GUGCAGGUCCAUUUCUGCCCACAGGUAGG VQVHFCPQVGCFSLIKRLTLLLPRTSQLN TTCTTTGATTAAGAGATTGACACTTCTGTTGCCTAG GUGUUUUUCUUUGAUUAAGAGAUUGACA HF GACCTCCCAACTCAACCATTTCTAG CUUCUGUUGCCUAGGACCUCCCAACUCAAC CAUUUCUAG 87 151/450 TTGTCATGGAGCTGCAGATTCCATTGCCCACCAAA UUGUCAUGGAGCUGCAGAUUCCAUUGCCC LSWSCRFHCPPKTRTHTYPYTKGKTILKCC GACTAGAACACACACATATCCATACACCAAAGGA ACCAAAGACUAGAACACACACAUAUCCAUA FSGGSLSGCCLTVWEPVLCRGDRPDLHYL AAGACAATTCTGAAATGCTGTTTCTCTGGTGGTTC CACCAAAGGAAAGACAAUUCUGAAAUGCU TTLALGANCPTVKCLGGCPIP CCTCTCTGGCTGCTGCCTCACAGTATGGGAACCTG GUUUCUCUGGUGGUUCCCUCUCUGGCUGC TACTCTGCAGAGGTGACAGGCCAGATTTGCATTAT UGCCUCACAGUAUGGGAACCUGUACUCUG CTCACAACCTTAGCCCTTGGTGCTAACTGTCCTAC CAGAGGUGACAGGCCAGAUUUGCAUUAUC AGTGAAGTGCCTGGGGGGTTGTCCTATCCCATAA UCACAACCUUAGCCCUUGGUGCUAACUGU CCUACAGUGAAGUGCCUGGGGGGUUGUCC UAUCCCAUAA 88 152/451 ATGCTGACAGCAGCCACCATCAGAATGACCCACG AUGCUGACAGCAGCCACCAUCAGAAUGACC MLTAATIRMTHAKKRKKKLKSPLTTQ CAAAAAAAAGAAAAAAAAAATTAAAAAGTCCCCT CACGCAAAAAAAAGAAAAAAAAAAUUAAAA CACAACCCAGTGA AGUCCCCUCACAACCCAGUGA 89 153/452 TTGATTAGGGAGTGCCTCAGACATGACATTCTTGT UUGAUUAGGGAGUGCCUCAGACAUGACAU LIRECLRHDILVLSLELIWQQEGADYVNR GCTGTCCTTGGAATTAATCTGGCAGCAGGAGGGA UCUUGUGCUGUCCUUGGAAUUAAUCUGG DKN GCAGACTATGTAAACAGAGATAAAAATTAA CAGCAGGAGGGAGCAGACUAUGUAAACAG AGAUAAAAAUUAA 90 154/453 TTGAAGGAAAAAAGAAATAAGAAGAGAGAGAGA UUGAAGGAAAAAAGAAAUAAGAAGAGAGA LKEKRNKKRERKKASHKDFLKRNNFA AAGAAAGCATCACACAAAGATTTTCTTAAAAGAA GAGAAAGAAAGCAUCACACAAAGAUUUUC ACAATTTTGCTTGA UUAAAAGAAACAAUUUUGCUUGA 91 155/454 GTGGCACTTGGCCTCCACTGGGCAGCAGGACCAG GUGGCACUUGGCCUCCACUGGGCAGCAGG VALGLHWAAGPAPSASVLFSFCNLGIFCC CTCCAAGCGCTAGTGTTCTGTTCTCTTTTTGTAATC ACCAGCUCCAAGCGCUAGUGUUCUGUUCU SKYN TTGGAATCTTTTGTTGCTCTAAATACAATTAA CUUUUUGUAAUCUUGGAAUCUUUUGUUG CUCUAAAUACAAUUAA 92 156/455 CTGGTCTGCCAGCTAAAACTTGGCCACATCCCCTG CUGGUCUGCCAGCUAAAACUUGGCCACAU LVCQLKLGHIPCYGCRIELLLTKRPKKSC TTATGGCTGCAGGATCGAGTTATTGTTAACAAAGA CCCCUGUUAUGGCUGCAGGAUCGAGUUAU GACCCAAGAAAAGCTGCTAA UGUUAACAAAGAGACCCAAGAAAAGCUGC UAA 93 157/456 GTGTCACTATGGAGCTCTCACATGTGGAAGCTGC GUGUCACUAUGGAGCUCUCACAUGUGGAA VSLWSSHMWKLQGLLQKSR AAGGTCTTCTTCAAAAGAGCCGCTGA GCUGCAAGGUCUUCUUCAAAAGAGCCGCU GA 94 158/457 CTGCCAGGGACCATGTTTTGCCCATTGACTATTAC CUGCCAGGGACCAUGUUUUGCCCAUUGAC LPGTMFCPLTITFHPRRPA TTTCCACCCCAGAAGACCTGCCTGA UAUUACUUUCCACCCCAGAAGACCUGCCU GA 95 159/458 GTGGAGATGAAGCTTCTGGGTGTCACTATGGAGC GUGGAGAUGAAGCUUCUGGGUGUCACUA VEMKLLGVTMELSHVEAARSSSKEPLK TCTCACATGTGGAAGCTGCAAGGTCTTCTTCAAAA UGGAGCUCUCACAUGUGGAAGCUGCAAGG GAGCCGCTGAAG UCUUCUUCAAAAGAGCCGCUGAAG 96 160/459 TTGGAGACTGCCAGGGACCATGTTTTGCCCATTGA UUGGAGACUGCCAGGGACCAUGUUUUGCC LETARDHVLPIDYYFPPQKTCLICGDEASG CTATTACTTTCCACCCCAGAAGACCTGCCTGATCT CAUUGACUAUUACUUUCCACCCCAGAAGA CHYGALTCGSCKVFFKRAAEVWRLPGT GTGGAGATGAAGCTTCTGGGTGTCACTATGGAGC CCUGCCUGAUCUGUGGAGAUGAAGCUUCU MFCPLTITFHPRRPA TCTCACATGTGGAAGCTGCAAGGTCTTCTTCAAAA GGGUGUCACUAUGGAGCUCUCACAUGUGG GAGCCGCTGAAGTTTGGAGACTGCCAGGGACCAT AAGCUGCAAGGUCUUCUUCAAAAGAGCCG GTTTTGCCCATTGACTATTACTTTCCACCCCAGAAG CUGAAGUUUGGAGACUGCCAGGGACCAUG ACCTGCCTGA UUUUGCCCAUUGACUAUUACUUUCCACCC CAGAAGACCUGCCUGA 97 161/460 GTGGAGATGAAGCTTCTGGGTGTCACTATGGAGC GUGGAGAUGAAGCUUCUGGGUGUCACUA VEMKLLGVTMELSHVEAARSSSKEPLKFG TCTCACATGTGGAAGCTGCAAGGTCTTCTTCAAAA UGGAGCUCUCACAUGUGGAAGCUGCAAGG DCQGPCFAH GAGCCGCTGAAGTTTGGAGACTGCCAGGGACCAT UCUUCUUCAAAAGAGCCGCUGAAGUUUGG GTTTTGCCCATTGA AGACUGCCAGGGACCAUGUUUUGCCCAUU GA 98(BSS) 162/461 CTGTGCGCCAGCAGAAATGATTGCACTATTGATAA CUGUGCGCCAGCAGAAAUGAUUGCACUAU LCASRNDCTIDKFRRKNCPSCRLRKCYEA ATTCCGAAGGAAAAATTGTCCATCTTGTCGTCTTC UGAUAAAUUCCGAAGGAAAAAUUGUCCAU GMTLGVWRLPGTMFCPLTITFHPRRPA GGAAATGTTATGAAGCAGGGATGACTCTGGGAGT CUUGUCGUCUUCGGAAAUGUUAUGAAGCA TTGGAGACTGCCAGGGACCATGTTTTGCCCATTGA GGGAUGACUCUGGGAGUUUGGAGACUGC CTATTACTTTCCACCCCAGAAGACCTGCCTGA CAGGGACCAUGUUUUGCCCAUUGACUAUU ACUUUCCACCCCAGAAGACCUGCCUGA 99(BSS) 163/462 ATGCACAAGTCCCGGATGTACAGCCAGTGTGTCC AUGCACAAGUCCCGGAUGUACAGCCAGUG MHKSRMYSQCVRMRHLSQEFGWLQITP GAATGAGGCACCTCTCTCAAGAGTTTGGATGGCT UGUCCGAAUGAGGCACCUCUCUCAAGAGU QEFLCMKALLLFSISFRNLHVDDQMAVIQ CCAAATCACCCCCCAGGAATTCCTGTGCATGAAAG UUGGAUGGCUCCAAAUCACCCCCCAGGAA YSWMGLMVFAMGWRSFTNVNSRMLY CACTGCTACTCTTCAGCATTAGCTTCCGCAACTTAC UUCCUGUGCAUGAAAGCACUGCUACUCUU FAPDLVFN ACGTGGACGACCAGATGGCTGTCATTCAGTACTCC CAGCAUUAGCUUCCGCAACUUACACGUGG TGGATGGGGCTCATGGTGTTTGCCATGGGCTGGC ACGACCAGAUGGCUGUCAUUCAGUACUCC GATCCTTCACCAATGTCAACTCCAGGATGCTCTAC UGGAUGGGGCUCAUGGUGUUUGCCAUGG TTCGCCCCTGATCTGGTTTTCAAT GCUGGCGAUCCUUCACCAAUGUCAACUCCA GGAUGCUCUACUUCGCCCCUGAUCUGGUU UUCAAU 100(BSS) 164/463 TTGCATGCAAAAGAAAAAATCCCACATCCTGCTCA UUGCAUGCAAAAGAAAAAAUCCCACAUCCU LHAKEKIPHPAQDASTSSPSSWTPCSLLP AGACGCTTCTACCAGCTCACCAAGCTCCTGGACTC GCUCAAGACGCUUCUACCAGCUCACCAAGC QLTRGRPDGCHSVLLDGAHGVCHGLAIL CGTGCAGCCTGCTTCCGCAACTTACACGTGGACGA UCCUGGACUCCGUGCAGCCUGCUUCCGCA HQCQLQDALLRP CCAGATGGCTGTCATTCAGTACTCCTGGATGGGG ACUUACACGUGGACGACCAGAUGGCUGUC CTCATGGTGTTTGCCATGGGCTGGCGATCCTTCAC AUUCAGUACUCCUGGAUGGGGCUCAUGGU CAATGTCAACTCCAGGATGCTCTACTTCGCCCCTG GUUUGCCAUGGGCUGGCGAUCCUUCACCA A AUGUCAACUCCAGGAUGCUCUACUUCGCC CCUGA 101(BSS) 165/464 ATGCAAAAGAAAAAATCCCACATCCTGCTCAAGAC AUGCAAAAGAAAAAAUCCCACAUCCUGCUC MQKKKSHILLKTLLPAHQAPGLRAACFRN GCTTCTACCAGCTCACCAAGCTCCTGGACTCCGTG AAGACGCUUCUACCAGCUCACCAAGCUCCU LHVDDQMAVIQYSWMGLMVFAMGW CAGCCTGCTTCCGCAACTTACACGTGGACGACCAG GGACUCCGUGCAGCCUGCUUCCGCAACUU RSFTNVNSRMLYFAPDLVFN ATGGCTGTCATTCAGTACTCCTGGATGGGGCTCAT ACACGUGGACGACCAGAUGGCUGUCAUUC GGTGTTTGCCATGGGCTGGCGATCCTTCACCAATG AGUACUCCUGGAUGGGGCUCAUGGUGUU TCAACTCCAGGATGCTCTACTTCGCCCCTGATCTG UGCCAUGGGCUGGCGAUCCUUCACCAAUG GTTTTCAAT UCAACUCCAGGAUGCUCUACUUCGCCCCU GAUCUGGUUUUCAAU 102(BSS) 166/465 GTGGATGGGCTGAAAAATCAAAAATTCTTTGATG GUGGAUGGGCUGAAAAAUCAAAAAUUCUU VDGLKNQKFFDELRMNYIKELDRIIACKR AACTTCGAATGAACTACATCAAGGAACTCGATCGT UGAUGAACUUCGAAUGAACUACAUCAAGG KNPTSCSRRFYQLTKLLDSVQPASATYTW ATCATTGCATGCAAAAGAAAAAATCCCACATCCTG AACUCGAUCGUAUCAUUGCAUGCAAAAGA TTRWLSFSTPGWGSWCLPWAGDPSPM CTCAAGACGCTTCTACCAGCTCACCAAGCTCCTGG AAAAAUCCCACAUCCUGCUCAAGACGCUUC STPGCSTSPLIWFSM ACTCCGTGCAGCCTGCTTCCGCAACTTACACGTGG UACCAGCUCACCAAGCUCCUGGACUCCGUG ACGACCAGATGGCTGTCATTCAGTACTCCTGGATG CAGCCUGCUUCCGCAACUUACACGUGGAC GGGCTCATGGTGTTTGCCATGGGCTGGCGATCCTT GACCAGAUGGCUGUCAUUCAGUACUCCUG CACCAATGTCAACTCCAGGATGCTCTACTTCGCCC GAUGGGGCUCAUGGUGUUUGCCAUGGGC CTGATCTGGTTTTCAATG UGGCGAUCCUUCACCAAUGUCAACUCCAG GAUGCUCUACUUCGCCCCUGAUCUGGUUU UCAAUG FOLH1 neo- antigen DNAsequence RNAsequence ProteinSequence 1 167/466 GTGGTATGTCACTCAGAAAGAATCGTAATGGGTA GUGGUAUGUCACUCAGAAAGAAUCGUAAU VVCHSERIVMGILINFKIGIFEIKLNIIYSYVS TATTGATAAATTTTAAAATTGGTATATTTGAAATAA GGGUAUAUUGAUAAAUUUUAAAAUUGGU VYICVCLYCLSSPYGLKLNFIIIRGYSEVEKF AGTTGAATATTATATATAGTTATGTGAGTGTTTAT AUAUUUGAAAUAAAGUUGAAUAUUAUAU NSVLNLRRMA ATATGTGTGTGTTTATATTGTTTATCTTCTCCCTAT AUAGUUAUGUGAGUGUUUAUAUAUGUGU GGATTAAAACTGAATTTCATAATTATAAGAGGTTA GUGUUUAUAUUGUUUAUCUUCUCCCUAU TTCTGAAGTGGAAAAATTTAACTCAGTATTAAATC GGAUUAAAACUGAAUUUCAUAAUUAUAAG TAAGGAGAATGGCCTAA AGGUUAUUCUGAAGUGGAAAAAUUUAAC UCAGUAUUAAAUCUAAGGAGAAUGGCCUA A 2 168/467 ATGTCACTTCACACAGAAGAAAACATCAGTATGTC AUGUCACUUCACACAGAAGAAAACAUCAG MSLHTEENISMSESTLGNMHKIIPSQRPH AGAGAGCACACTGGGGAATATGCACAAGATTATC UAUGUCAGAGAGCACACUGGGGAAUAUGC GLPGQPGLRGSLSQHTIWEMDQITLLVN CCAAGCCAGAGGCCTCACGGCCTACCTGGCCAGC ACAAGAUUAUCCCAAGCCAGAGGCCUCACG VITL CTGGGCTGAGAGGATCACTATCTCAGCACACTATT GCCUACCUGGCCAGCCUGGGCUGAGAGGA TGGGAAATGGATCAAATCACACTTTTAGTAAATGT UCACUAUCUCAGCACACUAUUUGGGAAAU TATCACTCTATAG GGAUCAAAUCACACUUUUAGUAAAUGUUA UCACUCUAUAG 3 169/468 ATGAACACTTGTGAACCTAATAGCCATATGAAGAA AUGAACACUUGUGAACCUAAUAGCCAUAU MNTCEPNSHMKKITFLISLDAPCTNDSYA AATAACATTTCTAATATCTTTGGATGCCCCATGTAC GAAGAAAAUAACAUUUCUAAUAUCUUUGG FAFS TAATGACAGTTATGCTTTTGCATTTTCTTGA AUGCCCCAUGUACUAAUGACAGUUAUGCU UUUGCAUUUUCUUGA 4 170/469 CTGTCATTATTTATAATTTTATCACACATGGCTGTA CUGUCAUUAUUUAUAAUUUUAUCACACAU LSLFIILSHMAVSFTCFGIMYF TCCTTTACATGTTTTGGCATTATGTATTTTTGA GGCUGUAUCCUUUACAUGUUUUGGCAUU AUGUAUUUUUGA 5 171/470 TTGACACTTCAGAACTCCCCAGAAACTTGTCTTCT UUGACACUUCAGAACUCCCCAGAAACUUG LTLQNSPETCLLGQCVKLFMKKCQARGA GGGCCAATGTGTAAAGCTGTTTATGAAGAAATGT UCUUCUGGGCCAAUGUGUAAAGCUGUUU LLQIWQRTISGEALGRWVLLATMNFRK CAAGCCAGAGGGGCTCTACTACAAATTTGGCAAA AUGAAGAAAUGUCAAGCCAGAGGGGCUCU WVP GGACAATTTCAGGAGAAGCTCTTGGCCGCTGGGT ACUACAAAUUUGGCAAAGGACAAUUUCAG TCTCCTGGCCACCATGAACTTCAGGAAGTGGGTG GAGAAGCUCUUGGCCGCUGGGUUCUCCUG CCATAG GCCACCAUGAACUUCAGGAAGUGGGUGCC AUAG 6 172/471 CTGGGCACTGGTGTAGCTCTGTATGCCCTCCGTGT CUGGGCACUGGUGUAGCUCUGUAUGCCCU LGTGVALYALRVRCWRCHLHCQSLPRVH CAGATGCTGGAGATGTCATTTGCATTGCCAGAGTT CCGUGUCAGAUGCUGGAGAUGUCAUUUGC TESRLKSTLLEHLSNAFYSQSLTSLTRDKEE TGCCAAGGGTGCACACAGAAAGCAGATTGAAAAG AUUGCCAGAGUUUGCCAAGGGUGCACACA LFNGPRSIYEDNQVGVWSG CACCCTCTTGGAACATCTCTCCAATGCCTTCTACTC GAAAGCAGAUUGAAAAGCACCCUCUUGGA ACAAAGTTTAACATCATTAACACGTGACAAAGAA ACAUCUCUCCAAUGCCUUCUACUCACAAAG GAACTATTTAATGGGCCCAGATCTATTTATGAAGA UUUAACAUCAUUAACACGUGACAAAGAAG CAATCAAGTGGGAGTTTGGAGTGGATAA AACUAUUUAAUGGGCCCAGAUCUAUUUAU GAAGACAAUCAAGUGGGAGUUUGGAGUG GAUAA 7 173/472 ATGCCCCATGTACTAATGACAGTTATGCTTTTGCA AUGCCCCAUGUACUAAUGACAGUUAUGCU MPHVLMTVMLLHFLEFYVYLSFLCHYL TTTTCTTGAATTTTATGTTTATTTATCTTTCCTCTGT UUUGCAUUUUCUUGAAUUUUAUGUUUAU CATTATTTATAA UUAUCUUUCCUCUGUCAUUAUUUAUAA 8 174/473 CTGTATCCTTTACATGTTTTGGCATTATGTATTTTT CUGUAUCCUUUACAUGUUUUGGCAUUAU LYPLHVLALCIFELFVKTIIPCVIFRDLIFFID GAACTTTTTGTAAAGACAATCATACCATGTGTAAT GUAUUUUUGAACUUUUUGUAAAGACAAU F TTTCAGGGACTTGATTTTTTTCATTGACTTTTAA CAUACCAUGUGUAAUUUUCAGGGACUUGA UUUUUUUCAUUGACUUUUAA 9 175/474 ATGGTGAATTTGGAGCAGCCAATGAAGAGTCCCC AUGGUGAAUUUGGAGCAGCCAAUGAAGAG MVNLEQPMKSPLTLWPRSKLRSRCSVAL TCACATTGTGGCCTCGCTCAAAGTTAAGAAGTCGC UCCCCUCACAUUGUGGCCUCGCUCAAAGU EESASN TGTAGTGTTGCCCTTGAAGAATCTGCTTCAAATTG UAAGAAGUCGCUGUAGUGUUGCCCUUGAA A GAAUCUGCUUCAAAUUGA 10 176/475 ATGCCCTCCGTGTCAGATGCTGGAGATGTCATTTG AUGCCCUCCGUGUCAGAUGCUGGAGAUGU MPSVSDAGDVICIARVCQGCTQKAD CATTGCCAGAGTTTGCCAAGGGTGCACACAGAAA CAUUUGCAUUGCCAGAGUUUGCCAAGGGU GCAGATTGA GCACACAGAAAGCAGAUUGA 11 177/476 GTGACAAAGAAGAACTATTTAATGGGCCCAGATC GUGACAAAGAAGAACUAUUUAAUGGGCCC VTKKNYLMGPDLFMKTIKWEFGVDNPN TATTTATGAAGACAATCAAGTGGGAGTTTGGAGT AGAUCUAUUUAUGAAGACAAUCAAGUGGG LDNW GGATAACCCAAATTTGGATAACTGGTGA AGUUUGGAGUGGAUAACCCAAAUUUGGA UAACUGGUGA 12 178/477 TTGAATTTGTGTGGTATGTCACTCAGAAAGAATCG UUGAAUUUGUGUGGUAUGUCACUCAGAA LNLCGMSLRKNRNGYIDKF TAATGGGTATATTGATAAATTTTAA AGAAUCGUAAUGGGUAUAUUGAUAAAUU UUAA 13 179/478 ATGTGTGTGTTTATATTGTTTATCTTCTCCCTATGG AUGUGUGUGUUUAUAUUGUUUAUCUUCU MCVFILFIFSLWIKTEFHNYKRLF ATTAAAACTGAATTTCATAATTATAAGAGGTTATT CCCUAUGGAUUAAAACUGAAUUUCAUAAU CTGA UAUAAGAGGUUAUUCUGA 14 180/479 TTGAATTTTATGTTTATTTATCTTTCCTCTGTCATTA UUGAAUUUUAUGUUUAUUUAUCUUUCCU LNFMFIYLSSVIIYNFITHGCILYMFWHYV TTTATAATTTTATCACACATGGCTGTATCCTTTACA CUGUCAUUAUUUAUAAUUUUAUCACACAU FLNFL TGTTTTGGCATTATGTATTTTTGAACTTTTTGTAA GGCUGUAUCCUUUACAUGUUUUGGCAUU AUGUAUUUUUGAACUUUUUGUAA 15 181/480 ATGAAATATTGTCTAGTAATATGTAAAGAGAAGTC AUGAAAUAUUGUCUAGUAAUAUGUAAAG MKYCLVICKEKSQEYVMSRCKELLLSPW TCAAGAATATGTGATGAGCAGATGTAAGGAATTG AGAAGUCUCAAGAAUAUGUGAUGAGCAGA CTCTTGTCTCCATGGTGA UGUAAGGAAUUGCUCUUGUCUCCAUGGU GA 16 182/481 GTGTTGCCCTTGAAGAATCTGCTTCAAATTGACAC GUGUUGCCCUUGAAGAAUCUGCUUCAAAU VLPLKNLLQIDTSELPRNLSSGPMCKAVY TTCAGAACTCCCCAGAAACTTGTCTTCTGGGCCAA UGACACUUCAGAACUCCCCAGAAACUUGUC EEMSSQRGSTTNLAKDNFRRSSWPLGSP TGTGTAAAGCTGTTTATGAAGAAATGTCAAGCCA UUCUGGGCCAAUGUGUAAAGCUGUUUAU GHHELQEVGAIAAA GAGGGGCTCTACTACAAATTTGGCAAAGGACAAT GAAGAAAUGUCAAGCCAGAGGGGCUCUAC TTCAGGAGAAGCTCTTGGCCGCTGGGTTCTCCTGG UACAAAUUUGGCAAAGGACAAUUUCAGGA CCACCATGAACTTCAGGAAGTGGGTGCCATAGCA GAAGCUCUUGGCCGCUGGGUUCUCCUGGC GCAGCCTGA CACCAUGAACUUCAGGAAGUGGGUGCCAU AGCAGCAGCCUGA 17 183/482 ATGCTGGAGATGTCATTTGCATTGCCAGAGTTTGC AUGCUGGAGAUGUCAUUUGCAUUGCCAGA MLEMSFALPEFAKGAHRKQIEKHPLGTSL CAAGGGTGCACACAGAAAGCAGATTGAAAAGCAC GUUUGCCAAGGGUGCACACAGAAAGCAGA QCLLLTKFNIINT CCTCTTGGAACATCTCTCCAATGCCTTCTACTCACA UUGAAAAGCACCCUCUUGGAACAUCUCUC AAGTTTAACATCATTAACACGTGA CAAUGCCUUCUACUCACAAAGUUUAACAU CAUUAACACGUGA 18 184/483 CTGAATGGTGCAGGAGACCCTCTCACACCAGGTT CUGAAUGGUGCAGGAGACCCUCUCACACC LNGAGDPLTPGYPANEYAYRRGIAEAVG ACCCAGCAAATGAATATGCTTATAGGCGTGGAATT AGGUUACCCAGCAAAUGAAUAUGCUUAUA LPSIPVHPIGYYDAQKLLEVVYKILQ GCAGAGGCTGTTGGTCTTCCAAGTATTCCTGTTCA GGCGUGGAAUUGCAGAGGCUGUUGGUCU TCCAATTGGATACTATGATGCACAGAAGCTCCTAG UCCAAGUAUUCCUGUUCAUCCAAUUGGAU AGGTGGTTTATAAAATCCTCCAATGA ACUAUGAUGCACAGAAGCUCCUAGAGGUG GUUUAUAAAAUCCUCCAAUGA 19(BSS) 185/484 CTGAGAACATCAAGAAGTTCTTATAGGTGGTTTAT CUGAGAACAUCAAGAAGUUCUUAUAGGUG LRTSRSSYRWFIKSSNEATNITPKHNMKA AAAATCCTCCAATGAAGCTACTAACATTACTCCAA GUUUAUAAAAUCCUCCAAUGAAGCUACUA FLDELKAENIKKFL AGCATAATATGAAAGCATTTTTGGATGAATTGAAA ACAUUACUCCAAAGCAUAAUAUGAAAGCA GCTGAGAACATCAAGAAGTTCTTA UUUUUGGAUGAAUUGAAAGCUGAGAACA UCAAGAAGUUCUUA 20(BSS) 186/485 TTGAACCACCTCCTCCAGGATATGAAAATGTTTCG UUGAACCACCUCCUCCAGGAUAUGAAAAU LNHLLQDMKMFRILYHLSVLSLLKECQRF GATATTGTACCACCTTTCAGTGCTTTCTCTCCTCAA GUUUCGGAUAUUGUACCACCUUUCAGUGC STHHYLNHLLQDMKMFRILYHLSVLSLLK GGAATGCCAGAGATTTTCAACACATCATTATTTGA UUUCUCUCCUCAAGGAAUGCCAGAGAUUU ECQ ACCACCTCCTCCAGGATATGAAAATGTTTCGGATA UCAACACAUCAUUAUUUGAACCACCUCCUC TTGTACCACCTTTCAGTGCTTTCTCTCCTCAAGGAA CAGGAUAUGAAAAUGUUUCGGAUAUUGU TGCCAG ACCACCUUUCAGUGCUUUCUCUCCUCAAG GAAUGCCAG Nkx3.1 neo- antigen DNAsequence RNAsequence ProteinSequence 1 187/486 GTGTGCACACCAAAGCTATTGGAGATTTGCGTGG GUGUGCACACCAAAGCUAUUGGAGAUUUG VCTPKLLEICVEISDSSLVRQ AAATCTCAGATTCTTCACTGGTGAGACAATGA CGUGGAAAUCUCAGAUUCUUCACUGGUGA GACAAUGA 2 188/487 ATGGTATGCCAACTTAAGTATTTACAGGGTGGCCC AUGGUAUGCCAACUUAAGUAUUUACAGGG MVCQLKYLQGGPNRTRCTRCDFKTSCIN AAATAGAACAAGATGCACTCGCTGTGATTTTAAGA UGGCCCAAAUAGAACAAGAUGCACUCGCU RTPLQEGGPGQENLRLSKTGA CAAGCTGTATAAACAGAACTCCACTGCAAGAGGG GUGAUUUUAAGACAAGCUGUAUAAACAGA GGGGCCGGGCCAGGAGAATCTCCGCTTGTCCAAG ACUCCACUGCAAGAGGGGGGGCCGGGCCA ACAGGGGCCTAA GGAGAAUCUCCGCUUGUCCAAGACAGGGG CCUAA 3 189/488 ATGAGCAGAGAGCAAAGGAGAAATCTGGCTGTCC AUGAGCAGAGAGCAAAGGAGAAAUCUGGC MSREQRRNLAVLPFSFCYLR TTCCATTTTCATTCTGTTATCTCAGGTGA UGUCCUUCCAUUUUCAUUCUGUUAUCUCA GGUGA 4 190/489 TTGGGCTCCACATTGCAATGTTCAATGCCACGTGC UUGGGCUCCACAUUGCAAUGUUCAAUGCC LGSTLQCSMPRAADTDRSTSQHKRQGSL TGCTGACACCGACCGGAGTACTAGCCAGCACAAA ACGUGCUGCUGACACCGACCGGAGUACUA NCFLLFTFLLK AGGCAGGGTAGCCTGAATTGCTTTCTGCTCTTTAC GCCAGCACAAAAGGCAGGGUAGCCUGAAU ATTTCTTTTAAAATAA UGCUUUCUGCUCUUUACAUUUCUUUUAA AAUAA 5 191/490 CTGAGTACTCTTTCTCTCCCCTCCTCTGAATTTAATT CUGAGUACUCUUUCUCUCCCCUCCUCUGA LSTLSLPSSEFNSFNLQFARITHFTVMYIVL CTTTCAACTTGCAATTTGCAAGGATTACACATTTCA AUUUAAUUCUUUCAACUUGCAAUUUGCAA QKKKKSVFV CTGTGATGTATATTGTGTTGCAAAAAAAAAAAAAA GGAUUACACAUUUCACUGUGAUGUAUAU AGTGTCTTTGTTTAA UGUGUUGCAAAAAAAAAAAAAAAGUGUCU UUGUUUAA 6 192/491 CTGACAGGTGAATTGGATGGTTCTCAGAACCATTT CUGACAGGUGAAUUGGAUGGUUCUCAGA LTGELDGSQNHFTQTACFYPV CACCCAGACAGCCTGTTTCTATCCTGTTTAA ACCAUUUCACCCAGACAGCCUGUUUCUAU CCUGUUUAA 7 193/492 CTGAAAACACTTCAGGCGCCCTTCCAAGGCTTCCC CUGAAAACACUUCAGGCGCCCUUCCAAGGC LKTLQAPFQGFPKPLSSRRSAPELPSPTLR CAAACCCCTAAGCAGCCGCAGAAGCGCTCCCGAG UUCCCCAAACCCCUAAGCAGCCGCAGAAGC CTGCCTTCTCCCACACTCAGGTGA GCUCCCGAGCUGCCUUCUCCCACACUCAGG UGA 8 194/493 CTGCCTTCCCCAGGGTGTCTCTATGAAAAGCACAA CUGCCUUCCCCAGGGUGUCUCUAUGAAAA LPSPGCLYEKHKGPRSGSKRCAHQSYWR GGGGCCAAGGTCAGGGAGCAAGAGGTGTGCACA GCACAAGGGGCCAAGGUCAGGGAGCAAGA FAWKSQILHW CCAAAGCTATTGGAGATTTGCGTGGAAATCTCAG GGUGUGCACACCAAAGCUAUUGGAGAUUU ATTCTTCACTGGTGA GCGUGGAAAUCUCAGAUUCUUCACUGGUG A 9 195/494 CTGTTTGAAGGGGAGAGAGGGAAAATCAAGTGG CUGUUUGAAGGGGAGAGAGGGAAAAUCA LFEGERGKIKWYFPALCMILDELYTQGFC TATTTTCCAGCACTTTGTATGATTTTGGATGAGTTG AGUGGUAUUUUCCAGCACUUUGUAUGAU SATPSSCVTEYQL TACACCCAAGGATTCTGTTCTGCAACTCCATCCTCC UUUGGAUGAGUUGUACACCCAAGGAUUCU TGTGTCACTGAATATCAACTCTGA GUUCUGCAACUCCAUCCUCCUGUGUCACU GAAUAUCAACUCUGA 10 196/495 CTGTTGGCCTTGGAATATGGCCAAGGCTCTCTCTG CUGUUGGCCUUGGAAUAUGGCCAAGGCUC LLALEYGQGSLCPCKREGQIESLQENALM TCCCTGTAAAAGAGAGGGGCAAATAGAGAGTCTC UCUCUGUCCCUGUAAAAGAGAGGGGCAAA LSTYLHGRGRWVGGDENISFSYSFLFLLK CAAGAGAACGCCCTCATGCTCAGCACATATTTGCA UAGAGAGUCUCCAAGAGAACGCCCUCAUG WYANLSIYRVAQIEQDALAVILRQAV TGGGAGGGGGAGATGGGTGGGAGGAGATGAAA CUCAGCACAUAUUUGCAUGGGAGGGGGAG ATATCAGCTTTTCTTATTCCTTTTTATTCCTTTTAAA AUGGGUGGGAGGAGAUGAAAAUAUCAGC ATGGTATGCCAACTTAAGTATTTACAGGGTGGCCC UUUUCUUAUUCCUUUUUAUUCCUUUUAA AAATAGAACAAGATGCACTCGCTGTGATTTTAAGA AAUGGUAUGCCAACUUAAGUAUUUACAGG CAAGCTGTATAA GUGGCCCAAAUAGAACAAGAUGCACUCGC UGUGAUUUUAAGACAAGCUGUAUAA 11 197/496 CTGGAGAATTTAGAATCAGAAGTTTCCTGGAGTTT CUGGAGAAUUUAGAAUCAGAAGUUUCCUG LENLESEVSWSFQAIIYTVS TCAGGCTATCATATATACTGTATCCTGA GAGUUUUCAGGCUAUCAUAUAUACUGUA UCCUGA 12 198/497 TTGGGGGCAGATTCTGAATTGGCTAAAAGACATG UUGGGGGCAGAUUCUGAAUUGGCUAAAA LGADSELAKRHAFLKLATLISFL CATTTTTAAAACTAGCAACTCTTATTTCTTTCCTTTA GACAUGCAUUUUUAAAACUAGCAACUCUU A AUUUCUUUCCUUUAA 13 199/498 TTGAGAATCTTTGCATGCAGAGGAGGTAAGAGGT UUGAGAAUCUUUGCAUGCAGAGGAGGUA LRIFACRGGKRYWIFTEEEHSAE ATTGGATTTTCACAGAGGAAGAACACAGCGCAGA AGAGGUAUUGGAUUUUCACAGAGGAAGA ATGA ACACAGCGCAGAAUGA 14 200/499 CTGTCCAGTGGAGGGCTCATGGGTGGGACATGGA CUGUCCAGUGGAGGGCUCAUGGGUGGGA LSSGGLMGGTWKRRQPRPWGAQSTEQ AAAGAAGGCAGCCTAGGCCCTGGGGAGCCCAGTC CAUGGAAAAGAAGGCAGCCUAGGCCCUGG ARD CACTGAGCAAGCAAGGGACTGA GGAGCCCAGUCCACUGAGCAAGCAAGGGA CUGA 15 201/500 GTGAGCCTTTTGCAGGAAAAGGCTAAGAAAAAGG GUGAGCCUUUUGCAGGAAAAGGCUAAGAA VSLLQEKAKKKENHSKTQQETVQMLWE AAAACCATTCTAAAACACAACAAGAAACTGTCCAA AAAGGAAAACCAUUCUAAAACACAACAAGA LCLLPIMGPQNG ATGCTTTGGGAACTGTGTTTATTGCCTATAATGGG AACUGUCCAAAUGCUUUGGGAACUGUGUU TCCCCAAAATGGGTAA UAUUGCCUAUAAUGGGUCCCCAAAAUGGG UAA 16 202/501 TTGGCCAATTTCACCCCATTTTCTGTGGTTTGGGCT UUGGCCAAUUUCACCCCAUUUUCUGUGGU LANFTPFSVVWAPHCNVQCHVLLTPTGV CCACATTGCAATGTTCAATGCCACGTGCTGCTGAC UUGGGCUCCACAUUGCAAUGUUCAAUGCC LASTKGRVA ACCGACCGGAGTACTAGCCAGCACAAAAGGCAGG ACGUGCUGCUGACACCGACCGGAGUACUA GTAGCCTGA GCCAGCACAAAAGGCAGGGUAGCCUGA 17 203/502 TTGTGTTGCAAAAAAAAAAAAAAAGTGTCTTTGTT UUGUGUUGCAAAAAAAAAAAAAAAGUGUC LCCKKKKKVSLFKITWFVNPSCFFPIGTSH TAAAATTACTTGGTTTGTGAATCCATCTTGCTTTTT UUUGUUUAAAAUUACUUGGUUUGUGAAU CCCCATTGGAACTAGTCATTAA CCAUCUUGCUUUUUCCCCAUUGGAACUAG UCAUUAA 18 204/503 GTGAATTGGATGGTTCTCAGAACCATTTCACCCAG GUGAAUUGGAUGGUUCUCAGAACCAUUUC VNWMVLRTISPRQPVSILFNKLVWVLYM ACAGCCTGTTTCTATCCTGTTTAATAAATTAGTTTG ACCCAGACAGCCUGUUUCUAUCCUGUUUA HNKPCSNLSHKSL GGTTCTCTACATGCATAACAAACCCTGCTCCAATC AUAAAUUAGUUUGGGUUCUCUACAUGCA TGTCACATAAAAGTCTGTGA UAACAAACCCUGCUCCAAUCUGUCACAUAA AAGUCUGUGA 19 205/504 CTGCGTGGGCAGCTGGAGCCCAGCTTTTTGGTAA CUGCGUGGGCAGCUGGAGCCCAGCUUUUU LRGQLEPSFLVMPAQVTTIMIKNCLPQG TGCCAGCTCAGGTGACAACCATTATGATCAAAAAC GGUAAUGCCAGCUCAGGUGACAACCAUUA VSMKSTRGQGQGARGVHTKAIGDLRGN TGCCTTCCCCAGGGTGTCTCTATGAAAAGCACAAG UGAUCAAAAACUGCCUUCCCCAGGGUGUC LRFFTGETMKQQRQ GGGCCAAGGTCAGGGAGCAAGAGGTGTGCACAC UCUAUGAAAAGCACAAGGGGCCAAGGUCA CAAAGCTATTGGAGATTTGCGTGGAAATCTCAGA GGGAGCAAGAGGUGUGCACACCAAAGCUA TTCTTCACTGGTGAGACAATGAAACAACAGAGAC UUGGAGAUUUGCGUGGAAAUCUCAGAUU AGTGA CUUCACUGGUGAGACAAUGAAACAACAGA GACAGUGA 20 206/505 TTGCTTCTGGCTACCTGTTTGAAGGGGAGAGAGG UUGCUUCUGGCUACCUGUUUGAAGGGGA LLLATCLKGREGKSSGIFQHFV GAAAATCAAGTGGTATTTTCCAGCACTTTGTATGA GAGAGGGAAAAUCAAGUGGUAUUUUCCAG CACUUUGUAUGA 21 207/506 ATGGGAGGGGGAGATGGGTGGGAGGAGATGAA AUGGGAGGGGGAGAUGGGUGGGAGGAGA MGGGDGWEEMKISAFLIPFYSF AATATCAGCTTTTCTTATTCCTTTTTATTCCTTTTAA UGAAAAUAUCAGCUUUUCUUAUUCCUUU UUAUUCCUUUUAA 22 208/507 CTGTATAAACAGAACTCCACTGCAAGAGGGGGGG CUGUAUAAACAGAACUCCACUGCAAGAGG LYKQNSTARGGAGPGESPLVQDRGLRRV CCGGGCCAGGAGAATCTCCGCTTGTCCAAGACAG GGGGGCCGGGCCAGGAGAAUCUCCGCUUG STLLLGAVAFFY GGGCCTAAGGAGGGTCTCCACACTGCTGCTAGGG UCCAAGACAGGGGCCUAAGGAGGGUCUCC GCTGTTGCATTTTTTTATTAG ACACUGCUGCUAGGGGCUGUUGCAUUUU UUUAUUAG 23 209/508 CTGTATCCTGAAAGGCAACATAATTCTTCCTTCCCT CUGUAUCCUGAAAGGCAACAUAAUUCUUC LYPERQHNSSFPPFKILCSFLQQLLTKGLH CCTTTTAAAATTTTGTGTTCCTTTTTGCAGCAATTA CUUCCCUCCUUUUAAAAUUUUGUGUUCCU FSPDF CTCACTAAAGGGCTTCATTTTAGTCCAGATTTTTAG UUUUGCAGCAAUUACUCACUAAAGGGCUU CAUUUUAGUCCAGAUUUUUAG 24 210/509 ATGCCTCGCTTATTTAGCCCGAGATCTGGTCTTTTT AUGCCUCGCUUAUUUAGCCCGAGAUCUGG MPRLFSPRSGLFFFFFFFFSVSPKLYLS TTTTTTTTTTTTTTTTTTTTTTCCGTCTCCCCAAAGCT UCUUUUUUUUUUUUUUUUUUUUUUUUU TTATCTGTCTTGA UUCCGUCUCCCCAAAGCUUUAUCUGUCUU GA 25 211/510 TTGCATGCAGAGGAGGTAAGAGGTATTGGATTTT UUGCAUGCAGAGGAGGUAAGAGGUAUUG LHAEEVRGIGFSQRKNTAQNEGPGLLSCP CACAGAGGAAGAACACAGCGCAGAATGAAGGGC GAUUUUCACAGAGGAAGAACACAGCGCAG VEGSWVGHGKEGSLGPGEPSPLSKQGTE CAGGCTTACTGAGCTGTCCAGTGGAGGGCTCATG AAUGAAGGGCCAGGCUUACUGAGCUGUCC GGTGGGACATGGAAAAGAAGGCAGCCTAGGCCC AGUGGAGGGCUCAUGGGUGGGACAUGGA TGGGGAGCCCAGTCCACTGAGCAAGCAAGGGACT AAAGAAGGCAGCCUAGGCCCUGGGGAGCC GAGTGA CAGUCCACUGAGCAAGCAAGGGACUGAGU GA 26 212/511 ATGGGTAACCTAGACTTCAGAGAGAATGAGCAGA AUGGGUAACCUAGACUUCAGAGAGAAUGA MGNLDFRENEQRAKEKSGCPSIFILLSQV GAGCAAAGGAGAAATCTGGCTGTCCTTCCATTTTC GCAGAGAGCAAAGGAGAAAUCUGGCUGUC SW ATTCTGTTATCTCAGGTGAGCTGGTAG CUUCCAUUUUCAUUCUGUUAUCUCAGGUG AGCUGGUAG 27 213/512 TTGAAGTTTAGTCAGCACCCCCACCAAACTTTATTT UUGAAGUUUAGUCAGCACCCCCACCAAACU LKFSQHPHQTLFFYVFFATYECFENKVPM TTCTATGTGTTTTTTGCAACATATGAGTGTTTTGAA UUAUUUUUCUAUGUGUUUUUUGCAACAU SLLDL AATAAAGTACCCATGTCTTTATTAGATTTA AUGAGUGUUUUGAAAAUAAAGUACCCAUG UCUUUAUUAGAUUUA 28(BSS) 214/513 GTGCGGGCCGGGCGGGTGCATTCAGGCCAAGGC GUGCGGGCCGGGCGGGUGCAUUCAGGCCA VRAGRVHSGQGGAAGMLRVPEPRPGEA GGGGCCGCCGGGATGCTCAGGGTTCCGGAGCCG AGGCGGGGCCGCCGGGAUGCUCAGGGUUC KAEGAAPPTPSKPLTSFLIQDILRDGAQR CGGCCCGGGGAGGCGAAAGCGGAGGGGGCCGC CGGAGCCGCGGCCCGGGGAGGCGAAAGCG QGGRTSSQRQRDPEPEPEPEPEGGRSRA GCCGCCGACCCCGTCCAAGCCGCTCACGTCCTTCC GAGGGGGCCGCGCCGCCGACCCCGUCCAAG GAQNDQLSTGPRAAPEEAETLAETEPGG TCATCCAGGACATCCTGCGGGACGGCGCGCAGCG CCGCUCACGUCCUUCCUCAUCCAGGACAUC AGRAGAFRPRRGRRDAQGSGAAARGGE GCAAGGCGGCCGCACGAGCAGCCAGAGACAGCG CUGCGGGACGGCGCGCAGCGGCAAGGCGG SGGGRAADPVQAAHVLPHPGHPAGRRA CGACCCGGAGCCGGAGCCAGAGCCAGAGCCAGA CCGCACGAGCAGCCAGAGACAGCGCGACCC AARRPHEQPETARPGAGARARARGRTQ GGGAGGACGCAGCCGCGCCGGGGCGCAGAACGA GGAGCCGGAGCCAGAGCCAGAGCCAGAGG PRRGAERPAEHRAPRRAGGGRDAGRDR CCAGCTGAGCACCGGGCCCCGCGCCGCGCCGGAG GAGGACGCAGCCGCGCCGGGGCGCAGAAC A GAGGCCGAGACGCTGGCAGAGACCGAGCCAGGC GACCAGCUGAGCACCGGGCCCCGCGCCGCG GGTGCGGGCCGGGCGGGTGCATTCAGGCCAAGG CCGGAGGAGGCCGAGACGCUGGCAGAGAC CGGGGCCGCCGGGATGCTCAGGGTTCCGGAGCC CGAGCCAGGCGGUGCGGGCCGGGCGGGUG GCGGCCCGGGGAGGCGAAAGCGGAGGGGGCCG CAUUCAGGCCAAGGCGGGGCCGCCGGGAU CGCCGCCGACCCCGTCCAAGCCGCTCACGTCCTTC GCUCAGGGUUCCGGAGCCGCGGCCCGGGG CTCATCCAGGACATCCTGCGGGACGGCGCGCAGC AGGCGAAAGCGGAGGGGGCCGCGCCGCCG GGCAAGGCGGCCGCACGAGCAGCCAGAGACAGC ACCCCGUCCAAGCCGCUCACGUCCUUCCUC GCGACCCGGAGCCGGAGCCAGAGCCAGAGCCAG AUCCAGGACAUCCUGCGGGACGGCGCGCA AGGGAGGACGCAGCCGCGCCGGGGCGCAGAACG GCGGCAAGGCGGCCGCACGAGCAGCCAGA ACCAGCTGAGCACCGGGCCCCGCGCCGCGCCGGA GACAGCGCGACCCGGAGCCGGAGCCAGAGC GGAGGCCGAGACGCTGGCAGAGACCGAGCC CAGAGCCAGAGGGAGGACGCAGCCGCGCC GGGGCGCAGAACGACCAGCUGAGCACCGG GCCCCGCGCCGCGCCGGAGGAGGCCGAGAC GCUGGCAGAGACCGAGCC NPYneo- antigen DNAsequence RNAsequence Proteinsequence 1 215/514 CTGGCTCTCACCCCTCGGAGACGCTCGCCCGACAG CUGGCUCUCACCCCUCGGAGACGCUCGCCC LALTPRRRSPDSIVLAAQPRPRASHHAR CATAGTACTTGCCGCCCAGCCACGCCCGCGCGCCA GACAGCAUAGUACUUGCCGCCCAGCCACGC GCCACCATGCTAGGTAA CCGCGCGCCAGCCACCAUGCUAGGUAA 2 216/515 GTGCCTGGGTGCGCTGGCCGAGGCGTACCCCTCC GUGCCUGGGUGCGCUGGCCGAGGCGUACC VPGCAGRGVPLQAGQPGRGRTSGGHG AAGCCGGACAACCCGGGCGAGGACGCACCAGCG CCUCCAAGCCGGACAACCCGGGCGAGGACG QILLGAATLHQPHHQAEIWKTIQPRDTD GAGGACATGGCCAGATACTACTCGGCGCTGCGAC CACCAGCGGAGGACAUGGCCAGAUACUAC FRPLDERKHRKCSQNSA ACTACATCAACCTCATCACCAGGCAGAGATATGGA UCGGCGCUGCGACACUACAUCAACCUCAUC AAACGATCCAGCCCAGAGACACTGATTTCAGACCT ACCAGGCAGAGAUAUGGAAAACGAUCCAG CTTGATGAGAGAAAGCACAGAAAATGTTCCCAGA CCCAGAGACACUGAUUUCAGACCUCUUGA ACTCGGCTTGA UGAGAGAAAGCACAGAAAAUGUUCCCAGA ACUCGGCUUGA 3 217/516 GTGGTGATGGGAAATGAGACTTGCTCTCTGGCCT GUGGUGAUGGGAAAUGAGACUUGCUCUC VVMGNETCSLAFSYFQPIFHRVKRESTHP TTTCCTATTTTCAGCCCATATTTCATCGTGTAAAAC UGGCCUUUUCCUAUUUUCAGCCCAUAUUU TNACSHCAEFCNVFLCHHCIYVCLNKVSC GAGAATCCACCCATCCTACCAATGCATGCAGCCAC CAUCGUGUAAAACGAGAAUCCACCCAUCCU IQK TGTGCTGAATTCTGCAATGTTTTCCTTTGTCATCAT ACCAAUGCAUGCAGCCACUGUGCUGAAUU TGTATATATGTGTGTTTAAATAAAGTATCATGCAT CUGCAAUGUUUUCCUUUGUCAUCAUUGU TCAAAAGTGA AUAUAUGUGUGUUUAAAUAAAGUAUCAU GCAUUCAAAAGUGA 4 218/517 ATGCATGCAGCCACTGTGCTGAATTCTGCAATGTT AUGCAUGCAGCCACUGUGCUGAAUUCUGC MHAATVLNSAMFSFVIIVYMCV TTCCTTTGTCATCATTGTATATATGTGTGTTTAA AAUGUUUUCCUUUGUCAUCAUUGUAUAU AUGUGUGUUUAA 5 219/518 GTGCGCTGGCCGAGGCGTACCCCTCCAAGCCGGA GUGCGCUGGCCGAGGCGUACCCCUCCAAG VRWPRRTPPSRTTRARTHQRRTWPDTT CAACCCGGGCGAGGACGCACCAGCGGAGGACAT CCGGACAACCCGGGCGAGGACGCACCAGCG RRCDTTSTSSPGRDMENDPAQRH GGCCAGATACTACTCGGCGCTGCGACACTACATCA GAGGACAUGGCCAGAUACUACUCGGCGCU ACCTCATCACCAGGCAGAGATATGGAAAACGATC GCGACACUACAUCAACCUCAUCACCAGGCA CAGCCCAGAGACACTGA GAGAUAUGGAAAACGAUCCAGCCCAGAGA CACUGA 6 220/519 TTGCTCTCTGGCCTTTTCCTATTTTCAGCCCATATTT UUGCUCUCUGGCCUUUUCCUAUUUUCAGC LLSGLFLFSAHISSCKTRIHPSYQCMQPLC CATCGTGTAAAACGAGAATCCACCCATCCTACCAA CCAUAUUUCAUCGUGUAAAACGAGAAUCC TGCATGCAGCCACTGTGCTGA ACCCAUCCUACCAAUGCAUGCAGCCACUGU GCUGA 7(BSS) 221/520 CTGATTTCAGACCTCTTGATGAGAGAAAGCACAG CUGAUUUCAGACCUCUUGAUGAGAGAAAG LISDLLMRESTENVPRTRYGKRSSPETLIS AAAATGTTCCCAGAACTCGATATGGAAAACGATCC CACAGAAAAUGUUCCCAGAACUCGAUAUG DLLMRESTENVPRT AGCCCAGAGACACTGATTTCAGACCTCTTGATGAG GAAAACGAUCCAGCCCAGAGACACUGAUU AGAAAGCACAGAAAATGTTCCCAGAACT UCAGACCUCUUGAUGAGAGAAAGCACAGA AAAUGUUCCCAGAACU 8(BSS) 222/521 GTGCCTGGGTGCGCTGGCCGAGGCGTACCCCTCC GUGCCUGGGUGCGCUGGCCGAGGCGUACC VPGCAGRGVPLQAGQPGRGRTSGGHG AAGCCGGACAACCCGGGCGAGGACGCACCAGCG CCUCCAAGCCGGACAACCCGGGCGAGGACG QILLGAATLHQPHHQAEMLGNKRLGLSG GAGGACATGGCCAGATACTACTCGGCGCTGCGAC CACCAGCGGAGGACAUGGCCAGAUACUAC LTLALSLLVCLGAEAYPSKPDNPGEDAPA ACTACATCAACCTCATCACCAGGCAGAGATGCTAG UCGGCGCUGCGACACUACAUCAACCUCAUC EDMARYYSALRHYINLITRQ GTAACAAGCGACTGGGGCTGTCCGGACTGACCCT ACCAGGCAGAGAUGCUAGGUAACAAGCGA CGCCCTGTCCCTGCTCGTGTGCCTGGGTGCGCTGG CUGGGGCUGUCCGGACUGACCCUCGCCCU CCGAGGCGTACCCCTCCAAGCCGGACAACCCGGG GUCCCUGCUCGUGUGCCUGGGUGCGCUGG CGAGGACGCACCAGCGGAGGACATGGCCAGATA CCGAGGCGUACCCCUCCAAGCCGGACAACC CTACTCGGCGCTGCGACACTACATCAACCTCATCA CGGGCGAGGACGCACCAGCGGAGGACAUG CCAGGCAG GCCAGAUACUACUCGGCGCUGCGACACUAC AUCAACCUCAUCACCAGGCAG SPDEFneo- antigen DNAsequence RNAsequence Proteinsequence 1 223/522 CTGACTTCCTCCCAGCACATTCCTGCACTCTGCCGT CUGACUUCCUCCCAGCACAUUCCUGCACUC LTSSQHIPALCRVHTAPQTQSSKPAASSL GTCCACACTGCCCCACAGACCCAGTCCTCCAAGCC UGCCGUGUCCACACUGCCCCACAGACCCAG QAPQVGPCHGASRQPWAGGRGLPTGT TGCTGCCAGCTCCCTGCAAGCCCCTCAGGTTGGGC UCCUCCAAGCCUGCUGCCAGCUCCCUGCAA QP CTTGCCACGGTGCCAGCAGGCAGCCCTGGGCTGG GCCCCUCAGGUUGGGCCUUGCCACGGUGC GGGTAGGGGACTCCCTACAGGCACGCAGCCCTGA CAGCAGGCAGCCCUGGGCUGGGGGUAGGG GACUCCCUACAGGCACGCAGCCCUGA 2 224/523 GTGGCCTCAGCTGCCCACACCTCTTCCCGGCCCCT GUGGCCUCAGCUGCCCACACCUCUUCCCGG VASAAHTSSRPLKLALQQTAPWAPGS GAAGTTGGCACTGCAGCAGACAGCTCCCTGGGCA CCCCUGAAGUUGGCACUGCAGCAGACAGC CCAGGCAGCTAA UCCCUGGGCACCAGGCAGCUAA 3 225/524 TTGACATGCTGTACCCTGAGGACAGCAGCTGGGC UUGACAUGCUGUACCCUGAGGACAGCAGC LTCCTLRTAAGQPRPLGPAVGRSHLRSLS AGCCAAGGCCCCTGGGGCCAGCAGTCGGGAGGA UGGGCAGCCAAGGCCCCUGGGGCCAGCAG SARSLTAKPQRAAWTWCPAG GCCACCTGAGGAGCCTGAGCAGTGCCCGGTCATT UCGGGAGGAGCCACCUGAGGAGCCUGAGC GACAGCCAAGCCCCAGCGGGCAGCCTGGACTTGG AGUGCCCGGUCAUUGACAGCCAAGCCCCAG TGCCCGGCGGGCTGA CGGGCAGCCUGGACUUGGUGCCCGGCGGG CUGA 4 226/525 ATGTGCAGAAGTGGCTCCTGTGGACAGAGCACCA AUGUGCAGAAGUGGCUCCUGUGGACAGAG MCRSGSCGQSTNTGCPPWARPSRSWR ATACCGGCTGCCCCCCATGGGCAAGGCCTTCCAG CACCAAUACCGGCUGCCCCCCAUGGGCAAG ARSCAPCRRSSSASARPWVGMCCTPTW GAGCTGGCGGGCAAGGAGCTGTGCGCCATGTCG GCCUUCCAGGAGCUGGCGGGCAAGGAGCU TSGSQRPG GAGGAGCAGTTCCGCCAGCGCTCGCCCCTGGGTG GUGCGCCAUGUCGGAGGAGCAGUUCCGCC GGGATGTGCTGCACGCCCACCTGGACATCTGGAA AGCGCUCGCCCCUGGGUGGGGAUGUGCUG GTCAGCGGCCTGGATGA CACGCCCACCUGGACAUCUGGAAGUCAGCG GCCUGGAUGA 5 227/526 CTGGGGCGATTCACTACTGTGCCTCGACCAGTGA CUGGGGCGAUUCACUACUGUGCCUCGACC LGRFTTVPRPVRRAGPTARWTHHAPGSP GGAGAGCTGGACCGACAGCGAGGTGGACTCATC AGUGAGGAGAGCUGGACCGACAGCGAGGU STCGSSSRSCYSSPTAMAASLGGSTRRRA ATGCTCCGGGCAGCCCATCCACCTGTGGCAGTTCC GGACUCAUCAUGCUCCGGGCAGCCCAUCCA SSKLRTQPRWPGCGASARTVPP TCAAGGAGTTGCTACTCAAGCCCCACAGCTATGGC CCUGUGGCAGUUCCUCAAGGAGUUGCUAC CGCTTCATTAGGTGGCTCAACAAGGAGAAGGGCA UCAAGCCCCACAGCUAUGGCCGCUUCAUUA TCTTCAAAATTGAGGACTCAGCCCAGGTGGCCCG GGUGGCUCAACAAGGAGAAGGGCAUCUUC GCTGTGGGGCATCCGCAAGAACCGTCCCGCCATG AAAAUUGAGGACUCAGCCCAGGUGGCCCG A GCUGUGGGGCAUCCGCAAGAACCGUCCCG CCAUGA 6 228/527 CTGGCCCAGGGCCTGAAACCCGCCCTCAGGGGCC CUGGCCCAGGGCCUGAAACCCGCCCUCAGG LAQGLKPALRGLSPACPASARP TCTCTCCTGCCTGCCCTGCCTCAGCCAGGCCCTGA GGCCUCUCUCCUGCCUGCCCUGCCUCAGCC AGGCCCUGA 7 229/528 CTGACCTTCCAGAGCCCAAGGTCAGGGAGGGGCA CUGACCUUCCAGAGCCCAAGGUCAGGGAG LTFQSPRSGRGNQLPQGDMGPLGPSGP ACCAACTGCCCCAGGGGGATATGGGTCCTCTGGG GGGCAACCAACUGCCCCAGGGGGAUAUGG WGRGASSSGPAAPLEDRGRQGCSPTPA GCCTTCGGGACCCTGGGGCAGGGGTGCTTCCTCC GUCCUCUGGGGCCUUCGGGACCCUGGGGC SDPSISRAEPTEGQ TCAGGCCCAGCTGCTCCCCTGGAGGACAGAGGGA AGGGGUGCUUCCUCCUCAGGCCCAGCUGC GACAGGGCTGCTCCCCAACACCTGCCTCTGACCCC UCCCCUGGAGGACAGAGGGAGACAGGGCU AGCATTTCCAGAGCAGAGCCTACAGAAGGGCAGT GCUCCCCAACACCUGCCUCUGACCCCAGCA GA UUUCCAGAGCAGAGCCUACAGAAGGGCAG UGA 8 230/529 ATGGTGCAGGGAGACATCTGCACCCCTGAGTTGG AUGGUGCAGGGAGACAUCUGCACCCCUGA MVQGDICTPELGSQECPREWIIKILEN GCAGCCAGGAGTGCCCCCGGGAATGGATAATAAA GUUGGGCAGCCAGGAGUGCCCCCGGGAAU GATACTAGAGAACTGA GGAUAAUAAAGAUACUAGAGAACUGA 9 231/530 CTGCACTCTGCCGTGTCCACACTGCCCCACAGACC CUGCACUCUGCCGUGUCCACACUGCCCCAC LHSAVSTLPHRPSPPSLLPAPCKPLRLGLA CAGTCCTCCAAGCCTGCTGCCAGCTCCCTGCAAGC AGACCCAGUCCUCCAAGCCUGCUGCCAGCU TVPAGSPGLGVGDSLQARSPETSEGHPL CCCTCAGGTTGGGCCTTGCCACGGTGCCAGCAGG CCCUGCAAGCCCCUCAGGUUGGGCCUUGC RVARPPVANLSAASATSPAGPWFRWPP CAGCCCTGGGCTGGGGGTAGGGGACTCCCTACAG CACGGUGCCAGCAGGCAGCCCUGGGCUGG RCLAETRQWPQLPTPLPGP GCACGCAGCCCTGAGACCTCAGAGGGCCACCCCT GGGUAGGGGACUCCCUACAGGCACGCAGC TGAGGGTGGCCAGGCCCCCAGTGGCCAACCTGAG CCUGAGACCUCAGAGGGCCACCCCUUGAG TGCTGCCTCTGCCACCAGCCCTGCTGGCCCCTGGT GGUGGCCAGGCCCCCAGUGGCCAACCUGA TCCGCTGGCCCCCCAGATGCCTGGCTGAGACACG GUGCUGCCUCUGCCACCAGCCCUGCUGGCC CCAGTGGCCTCAGCTGCCCACACCTCTTCCCGGCC CCUGGUUCCGCUGGCCCCCCAGAUGCCUG CCTGA GCUGAGACACGCCAGUGGCCUCAGCUGCCC ACACCUCUUCCCGGCCCCUGA 10 232/531 CTGGAGTCCCAGTCCACCCGCCACGCCCGAGCAG CUGGAGUCCCAGUCCACCCGCCACGCCCGA LESQSTRHARAGPVRLLPLLL GGCCTGTCCGCCTTCTACCTCTCCTACTTTGA GCAGGGCCUGUCCGCCUUCUACCUCUCCU ACUUUGA 11 233/532 CTGCAAGCTGCTCAACATCACCGCAGATCCCATGG CUGCAAGCUGCUCAACAUCACCGCAGAUCC LQAAQHHRRSHGLEPQQCAEVAPVDRA ACTGGAGCCCCAGCAATGTGCAGAAGTGGCTCCT CAUGGACUGGAGCCCCAGCAAUGUGCAGA PIPAAPHGQGLPGAGGQGAVRHVGGAV GTGGACAGAGCACCAATACCGGCTGCCCCCCATG AGUGGCUCCUGUGGACAGAGCACCAAUAC PPALAPGWGCAARPPGHLEVSGLDERA GGCAAGGCCTTCCAGGAGCTGGCGGGCAAGGAG CGGCUGCCCCCCAUGGGCAAGGCCUUCCAG DFTWGDSLLCLDQ CTGTGCGCCATGTCGGAGGAGCAGTTCCGCCAGC GAGCUGGCGGGCAAGGAGCUGUGCGCCAU GCTCGCCCCTGGGTGGGGATGTGCTGCACGCCCA GUCGGAGGAGCAGUUCCGCCAGCGCUCGC CCTGGACATCTGGAAGTCAGCGGCCTGGATGAAA CCCUGGGUGGGGAUGUGCUGCACGCCCAC GAGCGGACTTCACCTGGGGCGATTCACTACTGTG CUGGACAUCUGGAAGUCAGCGGCCUGGAU CCTCGACCAGTGA GAAAGAGCGGACUUCACCUGGGGCGAUUC ACUACUGUGCCUCGACCAGUGA 12 234/533 CTGGACCGACAGCGAGGTGGACTCATCATGCTCC CUGGACCGACAGCGAGGUGGACUCAUCAU LDRQRGGLIMLRAAHPPVAVPQGVATQ GGGCAGCCCATCCACCTGTGGCAGTTCCTCAAGG GCUCCGGGCAGCCCAUCCACCUGUGGCAG APQLWPLH AGTTGCTACTCAAGCCCCACAGCTATGGCCGCTTC UUCCUCAAGGAGUUGCUACUCAAGCCCCAC ATTAG AGCUAUGGCCGCUUCAUUAG 13 235/534 GTGGGGCATCCGCAAGAACCGTCCCGCCATGAAC GUGGGGCAUCCGCAAGAACCGUCCCGCCA VGHPQEPSRHELRQAEPLHPPVLQEGHH TACGACAAGCTGAGCCGCTCCATCCGCCAGTATTA UGAACUACGACAAGCUGAGCCGCUCCAUCC PEARHLPAPRLPVRAPHLSAWPRA CAAGAAGGGCATCATCCGGAAGCCAGACATCTCC GCCAGUAUUACAAGAAGGGCAUCAUCCGG CAGCGCCTCGTCTACCAGTTCGTGCACCCCATCTG AAGCCAGACAUCUCCCAGCGCCUCGUCUAC AGTGCCTGGCCCAGGGCCTGA CAGUUCGUGCACCCCAUCUGAGUGCCUGG CCCAGGGCCUGA 14 236/535 CTGCCTGCCCTGCCTCAGCCAGGCCCTGAGATGG CUGCCUGCCCUGCCUCAGCCAGGCCCUGAG LPALPQPGPEMGENGQSALLL GGGAAAACGGGCAGTCTGCTCTGCTGCTCTGA AUGGGGGAAAACGGGCAGUCUGCUCUGCU GCUCUGA 15 237/536 GTGCTTCCTCCTCAGGCCCAGCTGCTCCCCTGGAG GUGCUUCCUCCUCAGGCCCAGCUGCUCCCC VLPPQAQLLPWRTEGDRAAPQHLPLTPA GACAGAGGGAGACAGGGCTGCTCCCCAACACCTG UGGAGGACAGAGGGAGACAGGGCUGCUCC FPEQSLQKGSDSTKATGSPGLSLLHPPAS CCTCTGACCCCAGCATTTCCAGAGCAGAGCCTACA CCAACACCUGCCUCUGACCCCAGCAUUUCC HSAPHLAWCRETSAPLSWAARSAPGNG GAAGGGCAGTGACTCGACAAAGGCCACAGGCAG AGAGCAGAGCCUACAGAAGGGCAGUGACU TCCAGGCCTCTCTCTGCTCCATCCCCCTGCCTCCCA CGACAAAGGCCACAGGCAGUCCAGGCCUCU TTCTGCACCACACCTGGCATGGTGCAGGGAGACA CUCUGCUCCAUCCCCCUGCCUCCCAUUCUG TCTGCACCCCTGAGTTGGGCAGCCAGGAGTGCCC CACCACACCUGGCAUGGUGCAGGGAGACA CCGGGAATGGATAA UCUGCACCCCUGAGUUGGGCAGCCAGGAG UGCCCCCGGGAAUGGAUAA 16 238/537 CTGTCTGACTTCCTCCCAGCACATTCCTGCACTCTG CUGUCUGACUUCCUCCCAGCACAUUCCUGC LSDFLPAHSCTLPCPHCPTDPVLQACCQL CCGTGTCCACACTGCCCCACAGACCCAGTCCTCCA ACUCUGCCGUGUCCACACUGCCCCACAGAC PASPSGWALPRCQQAALGWG AGCCTGCTGCCAGCTCCCTGCAAGCCCCTCAGGTT CCAGUCCUCCAAGCCUGCUGCCAGCUCCCU GGGCCTTGCCACGGTGCCAGCAGGCAGCCCTGGG GCAAGCCCCUCAGGUUGGGCCUUGCCACG CTGGGGGTAG GUGCCAGCAGGCAGCCCUGGGCUGGGGGU AG 17 239/538 GTGCCTGGCCCAGGGCCTGAAACCCGCCCTCAGG GUGCCUGGCCCAGGGCCUGAAACCCGCCCU VPGPGPETRPQGPLSCLPCLSQALRWGK GGCCTCTCTCCTGCCTGCCCTGCCTCAGCCAGGCC CAGGGGCCUCUCUCCUGCCUGCCCUGCCUC TGSLLCCSDLPEPKVREGQPTAPGGYGSS CTGAGATGGGGGAAAACGGGCAGTCTGCTCTGCT AGCCAGGCCCUGAGAUGGGGGAAAACGGG GAFGTLGQGCFLLRPSCSPGGQRETGLLP GCTCTGACCTTCCAGAGCCCAAGGTCAGGGAGGG CAGUCUGCUCUGCUGCUCUGACCUUCCAG NTCL GCAACCAACTGCCCCAGGGGGATATGGGTCCTCT AGCCCAAGGUCAGGGAGGGGCAACCAACU GGGGCCTTCGGGACCCTGGGGCAGGGGTGCTTCC GCCCCAGGGGGAUAUGGGUCCUCUGGGGC TCCTCAGGCCCAGCTGCTCCCCTGGAGGACAGAG CUUCGGGACCCUGGGGCAGGGGUGCUUCC GGAGACAGGGCTGCTCCCCAACACCTGCCTCTGA UCCUCAGGCCCAGCUGCUCCCCUGGAGGAC AGAGGGAGACAGGGCUGCUCCCCAACACC UGCCUCUGA 18 240/539 GTGACTCGACAAAGGCCACAGGCAGTCCAGGCCT GUGACUCGACAAAGGCCACAGGCAGUCCA VTRQRPQAVQASLCSIPLPPILHHTWHG CTCTCTGCTCCATCCCCCTGCCTCCCATTCTGCACC GGCCUCUCUCUGCUCCAUCCCCCUGCCUCC AGRHLHP ACACCTGGCATGGTGCAGGGAGACATCTGCACCC CAUUCUGCACCACACCUGGCAUGGUGCAG CTGA GGAGACAUCUGCACCCCUGA TP53neo- antigen DNAsequence RNAsequence Proteinsequence 1 241/540 CTGACATTCTCCACTTCTTGTTCCCCACTGACAGCC CUGACAUUCUCCACUUCUUGUUCCCCACU LTFSTSCSPLTASHPHLSLPCHFGFWVFEP TCCCACCCCCATCTCTCCCTCCCCTGCCATTTTGGG GACAGCCUCCCACCCCCAUCUCUCCCUCCCC LLAIGVRQKHPGLPFALSRGSTEQVGLH TTTTGGGTCTTTGAACCCTTGCTTGCAATAGGTGT UGCCAUUUUGGGUUUUGGGUCUUUGAAC WCFVVGRRMGSRTYQLRF GCGTCAGAAGCACCCAGGACTTCCATTTGCTTTGT CCUUGCUUGCAAUAGGUGUGCGUCAGAAG CCCGGGGCTCCACTGAACAAGTTGGCCTGCACTG CACCCAGGACUUCCAUUUGCUUUGUCCCG GTGTTTTGTTGTGGGGAGGAGGATGGGGAGTAG GGGCUCCACUGAACAAGUUGGCCUGCACU GACATACCAGCTTAGATTTTAA GGUGUUUUGUUGUGGGGAGGAGGAUGG GGAGUAGGACAUACCAGCUUAGAUUUUAA 2 242/541 TTGGGCAGCTGGTTAGGTAGAGGGAGTTGTCAAG UUGGGCAGCUGGUUAGGUAGAGGGAGUU LGSWLGRGSCQVSAGPAKPCLTTSW TCTCTGCTGGCCCAGCCAAACCCTGTCTGACAACC GUCAAGUCUCUGCUGGCCCAGCCAAACCCU TCTTGGTGA GUCUGACAACCUCUUGGUGA 3 243/542 ATGGGATTGGGGTTTTCCCCTCCCATGTGCTCAAG AUGGGAUUGGGGUUUUCCCCUCCCAUGU MGLGFSPPMCSRLALKVLSFSKV ACTGGCGCTAAAAGTTTTGAGCTTCTCAAAAGTCT GCUCAAGACUGGCGCUAAAAGUUUUGAGC AG UUCUCAAAAGUCUAG 4 244/543 TTGTTCCCTCTCCCTGTTGGTCGGTGGGTTGGTAG UUGUUCCCUCUCCCUGUUGGUCGGUGGG LFPLPVGRWVGSFYSWAAG TTTCTACAGTTGGGCAGCTGGTTAG UUGGUAGUUUCUACAGUUGGGCAGCUGG UUAG 5 245/544 CTGACTCAGACTGACATTCTCCACTTCTTGTTCCCC CUGACUCAGACUGACAUUCUCCACUUCUU LTQTDILHFLFPTDSLPPPSLPPLPFWVLG ACTGACAGCCTCCCACCCCCATCTCTCCCTCCCCTG GUUCCCCACUGACAGCCUCCCACCCCCAUC L CCATTTTGGGTTTTGGGTCTTTGA UCUCCCUCCCCUGCCAUUUUGGGUUUUGG GUCUUUGA 6 246/545 CTGTCCCTCACTGTTGAATTTTCTCTAACTTCAAGG CUGUCCCUCACUGUUGAAUUUUCUCUAAC LSLTVEFSLTSRPISVKCWHLHLPHRVHCE CCCATATCTGTGAAATGCTGGCATTTGCACCTACC UUCAAGGCCCAUAUCUGUGAAAUGCUGGC G TCACAGAGTGCATTGTGAGGGTTAA AUUUGCACCUACCUCACAGAGUGCAUUGU GAGGGUUAA 7 247/546 CTGGCCTTGAAACCACCTTTTATTACATGGGGTCT CUGGCCUUGAAACCACCUUUUAUUACAUG LALKPPFITWGLELDPLEGACSLSLLVGGL AGAACTTGACCCCCTTGAGGGTGCTTGTTCCCTCT GGGUCUAGAACUUGACCCCCUUGAGGGUG VVSTVGQLVR CCCTGTTGGTCGGTGGGTTGGTAGTTTCTACAGTT CUUGUUCCCUCUCCCUGUUGGUCGGUGGG GGGCAGCTGGTTAGGTAG UUGGUAGUUUCUACAGUUGGGCAGCUGG UUAGGUAG 8 248/547 TTGTCAAGTCTCTGCTGGCCCAGCCAAACCCTGTC UUGUCAAGUCUCUGCUGGCCCAGCCAAAC LSSLCWPSQTLSDNLLVNLST TGACAACCTCTTGGTGAACCTTAGTACCTAA CCUGUCUGACAACCUCUUGGUGAACCUUA GUACCUAA 9 249/548 CTGGATCCACCAAGACTTGTTTTATGCTCAGGGTC CUGGAUCCACCAAGACUUGUUUUAUGCUC LDPPRLVLCSGSISFFFFFFFFLFL AATTTCTTTTTTCTTTTTTTTTTTTTTTTTTCTTTTTCT AGGGUCAAUUUCUUUUUUCUUUUUUUUU TTGA UUUUUUUUUCUUUUUCUUUGA 10 250/549 GTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCA GUGUUGCCCAGGCUGGUCUCAAACUCCU GVLPRLVSNSWAQAIHLSQPPRVLGLQL GGCGATCCACCTGTCTCAGCCTCCCAGAGTGCTGG GGCUCAGGCGAUCCACCUGUCUCAGCCUCC GATTACAATTGTGA CAGAGUGCUGGGAUUACAAUUGUGA ERGneo- antigen DNAsequences RNAsequences Proteinsequences 1 251/550 CTGGACCGGTCACGGCCACCCCACGCCCCAGTCG CUGGACCGGUCACGGCCACCCCACGCCCCA LDRSRPPHAPVESCSTISFHSAQN AAAGCTGCTCAACCATCTCCTTCCACAGTGCCCAA GUCGAAAGCUGCUCAACCAUCUCCUUCCAC AACTGA AGUGCCCAAAACUGA 2 252/551 TTGGCAGTTCCTCCTGGAGCTCCTGTCGGACAGCT UUGGCAGUUCCUCCUGGAGCUCCUGUCGG LAVPPGAPVGQLQLQLHHLGRHQRGVQ CCAACTCCAGCTGCATCACCTGGGAAGGCACCAA ACAGCUCCAACUCCAGCUGCAUCACCUGGG DDGSRRGGPALGRAEEQTQHELR CGGGGAGTTCAAGATGACGGATCCCGACGAGGT AAGGCACCAACGGGGAGUUCAAGAUGACG GGCCCGGCGCTGGGGAGAGCGGAAGAGCAAACC GAUCCCGACGAGGUGGCCCGGCGCUGGGG CAACATGAACTACGATAA AGAGCGGAAGAGCAAACCCAACAUGAACUA CGAUAA 3 253/552 GTGGCCCATCAACAGACGTTGATATGCAACTGCAT GUGGCCCAUCAACAGACGUUGAUAUGCAA VAHQQTLICNCMACAVLVEIKYIPFDGQL GGCATGTGCTGTTTTGGTTGAAATCAAATACATTC CUGCAUGGCAUGUGCUGUUUUGGUUGAA SAFSNCEDDPKFPTPLQYYRDYELKGGTE CGTTTGATGGACAGCTGTCAGCTTTCTCAAACTGT AUCAAAUACAUUCCGUUUGAUGGACAGCU DVYRVSV GAAGATGACCCAAAGTTTCCAACTCCTTTACAGTA GUCAGCUUUCUCAAACUGUGAAGAUGACC TTACCGGGACTATGAACTAAAAGGTGGGACTGAG CAAAGUUUCCAACUCCUUUACAGUAUUAC GATGTGTATAGAGTGAGCGTGTGA CGGGACUAUGAACUAAAAGGUGGGACUGA GGAUGUGUAUAGAGUGAGCGUGUGA 4 254/553 CTGGACTCAGGACATTTGGGGACTGTGTACAATG CUGGACUCAGGACAUUUGGGGACUGUGU LDSGHLGTVYNELWRLEGSCSQCYTKPS AGTTATGGAGACTCGAGGGTTCATGCAGTCAGTG ACAAUGAGUUAUGGAGACUCGAGGGUUCA VRRKDTA TTATACCAAACCCAGTGTTAGGAGAAAGGACACA UGCAGUCAGUGUUAUACCAAACCCAGUGU GCGTAA UAGGAGAAAGGACACAGCGUAA 5 255/554 ATGGCCTTCTTGGCTGCCACAATCAGAAATCACGC AUGGCCUUCUUGGCUGCCACAAUCAGAAA MAFLAATIRNHAGILGRRPPVFL AGGCATTTTGGGTAGGCGGCCTCCAGTTTTCCTTT UCACGCAGGCAUUUUGGGUAGGCGGCCUC GA CAGUUUUCCUUUGA 6 256/555 ATGCTTAATGTTTACAATATGAAGTTATTAGTTCTT AUGCUUAAUGUUUACAAUAUGAAGUUAU MLNVYNMKLLVLRMQNVCNKISLA AGAATGCAGAATGTATGTAATAAAATAAGCTTGG UAGUUCUUAGAAUGCAGAAUGUAUGUAA CCTAG UAAAAUAAGCUUGGCCUAG 7 257/556 TTGGGATTCACTAGCCCTGAGCCTGATGTTGCTGG UUGGGAUUCACUAGCCCUGAGCCUGAUGU LGFTSPEPDVAGYPLKTMFISII CTATCCCTTGAAGACAATGTTTATTTCCATAATCTA UGCUGGCUAUCCCUUGAAGACAAUGUUUA G UUUCCAUAAUCUAG 8 258/557 ATGTTTTCCATTAGATCCCTCAACCCTCCACCCCCA AUGUUUUCCAUUAGAUCCCUCAACCCUCC MFSIRSLNPPPPVQVISKSYEQLG GTCCAGGTTATTAGCAAGTCTTATGAGCAACTGG ACCCCCAGUCCAGGUUAUUAGCAAGUCUU GATAA AUGAGCAACUGGGAUAA 9 259/558 GTGGCACCTGCAACCCAGGAGCAGGAGCCGGAG GUGGCACCUGCAACCCAGGAGCAGGAGCC VAPATQEQEPEELPSDSRCSRDGYSSGA GAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATG GGAGGAGCUGCCCUCUGACAGCAGGUGCA GKVMGHRESTDVLQRPKVTHCLEKEKKI GCTACAGCTCAGGAGCTGGGAAGGTGATGGGGC GCAGAGAUGGCUACAGCUCAGGAGCUGGG FFKKLVYLASH ACAGGGAAAGCACAGATGTTCTGCAGCGCCCCAA AAGGUGAUGGGGCACAGGGAAAGCACAGA AGTGACCCATTGCCTGGAGAAAGAGAAGAAAATA UGUUCUGCAGCGCCCCAAAGUGACCCAUU TTTTTTAAAAAGCTAGTTTATTTAGCTTCTCATTAA GCCUGGAGAAAGAGAAGAAAAUAUUUUUU AAAAAGCUAGUUUAUUUAGCUUCUCAUUA A 10 260/559 ATGAATCAAAAGTGCCTCAAGAGGAATGAAAAAA AUGAAUCAAAAGUGCCUCAAGAGGAAUGA MNQKCLKRNEKSFTGAGEGSRGRDPKTL GCTTTACTGGGGCTGGGGAAGGAAGCCGGGGAA AAAAAGCUUUACUGGGGCUGGGGAAGGAA GRELLKSYYRNEEDAKNVTNMDISSVD GAGATCCAAAGACTCTTGGGAGGGAGTTACTGAA GCCGGGGAAGAGAUCCAAAGACUCUUGGG GTCTTACTACAGAAATGAGGAGGATGCTAAAAAT AGGGAGUUACUGAAGUCUUACUACAGAAA GTCACGAATATGGACATATCATCTGTGGACTGA UGAGGAGGAUGCUAAAAAUGUCACGAAUA UGGACAUAUCAUCUGUGGACUGA 11 261/560 GTGCTGTTTTGGTTGAAATCAAATACATTCCGTTT GUGCUGUUUUGGUUGAAAUCAAAUACAU VLFWLKSNTFRLMDSCQLSQTVKMTQSF GATGGACAGCTGTCAGCTTTCTCAAACTGTGAAG UCCGUUUGAUGGACAGCUGUCAGCUUUCU QLLYSITGTMN ATGACCCAAAGTTTCCAACTCCTTTACAGTATTACC CAAACUGUGAAGAUGACCCAAAGUUUCCA GGGACTATGAACTAA ACUCCUUUACAGUAUUACCGGGACUAUGA ACUAA 12 262/561 CTGTGTACAATGAGTTATGGAGACTCGAGGGTTC CUGUGUACAAUGAGUUAUGGAGACUCGA LCTMSYGDSRVHAVSVIPNPVLGERTQR ATGCAGTCAGTGTTATACCAAACCCAGTGTTAGGA GGGUUCAUGCAGUCAGUGUUAUACCAAAC NGERGSSRIQKQKCASLSLFVK GAAAGGACACAGCGTAATGGAGAAAGGGGAAGT CCAGUGUUAGGAGAAAGGACACAGCGUAA AGTAGAATTCAGAAACAAAAATGCGCATCTCTTTC UGGAGAAAGGGGAAGUAGUAGAAUUCAG TTTGTTTGTCAAATGA AAACAAAAAUGCGCAUCUCUUUCUUUGUU UGUCAAAUGA 13 263/562 GTGGGGGCTTTGTTCTCCACAGGGTCAGGTAAGA GUGGGGGCUUUGUUCUCCACAGGGUCAG VGALFSTGSGKRWPSWLPQSEITQAFW GATGGCCTTCTTGGCTGCCACAATCAGAAATCACG GUAAGAGAUGGCCUUCUUGGCUGCCACAA VGGLQFSFESRTLCVCQNEVYKSMFFPLF CAGGCATTTTGGGTAGGCGGCCTCCAGTTTTCCTT UCAGAAAUCACGCAGGCAUUUUGGGUAGG I TGAGTCGCGAACGCTGTGCGTTTGTCAGAATGAA CGGCCUCCAGUUUUCCUUUGAGUCGCGAA GTATACAAGTCAATGTTTTTCCCCCTTTTTATATAA CGCUGUGCGUUUGUCAGAAUGAAGUAUAC AAGUCAAUGUUUUUCCCCCUUUUUAUAUA A 14 264/563 ATGAAAACATGTGCTGAATGTTGTGGATTTTGTGT AUGAAAACAUGUGCUGAAUGUUGUGGAU MKTCAECCGFCVIIYFVQELVQGRAKEIG TATAATTTACTTTGTCCAGGAACTTGTGCAAGGGA UUUGUGUUAUAAUUUACUUUGUCCAGGA CLAPKWRQPLQVLLASPPVFYF GAGCCAAGGAAATAGGATGTTTGGCACCCAAATG ACUUGUGCAAGGGAGAGCCAAGGAAAUAG GCGTCAGCCTCTCCAGGTCCTTCTTGCCTCCCCTCC GAUGUUUGGCACCCAAAUGGCGUCAGCCU TGTCTTTTATTTCTAG CUCCAGGUCCUUCUUGCCUCCCCUCCUGUC UUUUAUUUCUAG 15 265/564 TTGGAACAGAAGGACCCCGGGTTTCACATTGGAG UUGGAACAGAAGGACCCCGGGUUUCACAU LEQKDPGFHIGASIFMPGMERGL CCTCCATATTTATGCCTGGAATGGAAAGAGGCCTA UGGAGCCUCCAUAUUUAUGCCUGGAAUGG TGA AAAGAGGCCUAUGA 16 266/565 GTGAACAAGCTACCACTCGTAAGGCAAACTGTATT GUGAACAAGCUACCACUCGUAAGGCAAAC VNKLPLVRQTVLLLANKASWIAAISHFTET ATTACTGGCAAATAAAGCGTCATGGATAGCTGCA UGUAUUAUUACUGGCAAAUAAAGCGUCAU RDNV ATTTCTCACTTTACAGAAACAAGGGATAACGTCTA GGAUAGCUGCAAUUUCUCACUUUACAGAA G ACAAGGGAUAACGUCUAG 17 267/566 CTGCTACATCAGAGTTACCTGGGCACTGTGGCTTG CUGCUACAUCAGAGUUACCUGGGCACUGU LLHQSYLGTVAWDSLALSLMLLAIP GGATTCACTAGCCCTGAGCCTGATGTTGCTGGCTA GGCUUGGGAUUCACUAGCCCUGAGCCUGA TCCCTTGA UGUUGCUGGCUAUCCCUUGA 18 268/567 ATGCTGCCAACCTTGGTCCAGGTGAAGGCAACTC AUGCUGCCAACCUUGGUCCAGGUGAAGGC MLPTLVQVKATQKVKIQGDRAKALAETS AAAAGGTGAAAATACAAGGTGACCGTGCGAAGG AACUCAAAAGGUGAAAAUACAAGGUGACC CGCTAGCCGAAACATCTTAG GUGCGAAGGCGCUAGCCGAAACAUCUUAG 19 269/568 GTGCTGTGGATGTTTTGGCAGTGGGCTTTGAAGT GUGCUGUGGAUGUUUUGGCAGUGGGCUU VLWMFWQWALKSAGHDYQCS CGGCAGGACACGATTACCAATGCTCCTGA UGAAGUCGGCAGGACACGAUUACCAAUGC UCCUGA 20 270/569 GTGTCATTTGGATTAGACGGAGCCCAACCATCCAT GUGUCAUUUGGAUUAGACGGAGCCCAACC VSFGLDGAQPSIILQQPGKAHKVPVSP CATTTTGCAGCAGCCTGGGAAGGCCCACAAAGTG AUCCAUCAUUUUGCAGCAGCCUGGGAAGG CCCGTATCTCCTTAG CCCACAAAGUGCCCGUAUCUCCUUAG 21 271/570 ATGATTATCATATTCAATTTTAACAGATGTTTTCCA AUGAUUAUCAUAUUCAAUUUUAACAGAUG MIIIFNFNRCFPLDPSTLHPQSRLLASLMS TTAGATCCCTCAACCCTCCACCCCCAGTCCAGGTT UUUUCCAUUAGAUCCCUCAACCCUCCACCC NWDNFG ATTAGCAAGTCTTATGAGCAACTGGGATAATTTTG CCAGUCCAGGUUAUUAGCAAGUCUUAUGA GATAA GCAACUGGGAUAAUUUUGGAUAA 22 272/571 CTGTACAATCTTACTCCTGCTGGCAAGAGATTTGT CUGUACAAUCUUACUCCUGCUGGCAAGAG LYNLTPAGKRFVFFSCLQLAFGPCMW CTTCTTTTCTTGTCTTCAATTGGCTTTCGGGCCTTG AUUUGUCUUCUUUUCUUGUCUUCAAUUG TATGTGGTAA GCUUUCGGGCCUUGUAUGUGGUAA 23 273/572 ATGTGGCACCTGCAACCCAGGAGCAGGAGCCGGA AUGUGGCACCUGCAACCCAGGAGCAGGAG MWHLQPRSRSRRSCPLTAGAAEMATAQ GGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGAT CCGGAGGAGCUGCCCUCUGACAGCAGGUG ELGR GGCTACAGCTCAGGAGCTGGGAAGGTGA CAGCAGAGAUGGCUACAGCUCAGGAGCUG GGAAGGUGA 24 274/573 GTGAGGACCAGTCGTTGTTTGAGTGTGCCTACGG GUGAGGACCAGUCGUUGUUUGAGUGUGC VRTSRCLSVPTERHTWLRQR AACGCCACACCTGGCTAAGACAGAGATGA CUACGGAACGCCACACCUGGCUAAGACAGA GAUGA 25 275/574 ATGGCTCAAGGAACTCTCCTGATGAATGCAGTGT AUGGCUCAAGGAACUCUCCUGAUGAAUGC MAQGTLLMNAVWPKAGRWWAAQTPL GGCCAAAGGCGGGAAGATGGTGGGCAGCCCAGA AGUGUGGCCAAAGGCGGGAAGAUGGUGG G CACCGTTGGGATGA GCAGCCCAGACACCGUUGGGAUGA 26 276/575 ATGGCCTTCCAGACGTCAACATCTTGTTATTCCAG AUGGCCUUCCAGACGUCAACAUCUUGUUA MAFQTSTSCYSRTSMGRNCAR AACATCGATGGGAAGGAACTGTGCAAGATGA UUCCAGAACAUCGAUGGGAAGGAACUGUG CAAGAUGA 27 277/576 ATGCTAGAAACACAGGGGGTGCAGCTTTTATTTTC AUGCUAGAAACACAGGGGGUGCAGCUUUU MLETQGVQLLFSQ1LQYILKLRKELQLGQI CCAAATACTTCAGTATATCCTGAAGCTACGCAAAG AUUUUCCCAAAUACUUCAGUAUAUCCUGA YHMSPPGDQPGPVTATPRPSRKLLNHLL AATTACAACTAGGCCAGATTTACCATATGAGCCCC AGCUACGCAAAGAAUUACAACUAGGCCAG PQCPKLKTSVLS CCAGGAGATCAGCCTGGACCGGTCACGGCCACCC AUUUACCAUAUGAGCCCCCCAGGAGAUCA CACGCCCCAGTCGAAAGCTGCTCAACCATCTCCTT GCCUGGACCGGUCACGGCCACCCCACGCCC CCACAGTGCCCAAAACTGAAGACCAGCGTCCTCA CAGUCGAAAGCUGCUCAACCAUCUCCUUCC GTTAG ACAGUGCCCAAAACUGAAGACCAGCGUCCU CAGUUAG 28 278/577 TTGGACCAACAAGTAGCCGCCTTGCAAATCCAGG UUGGACCAACAAGUAGCCGCCUUGCAAAU LDQQVAALQIQAVARSSFGSSSWSSCRT CAGTGGCCAGATCCAGCTTTGGCAGTTCCTCCTGG CCAGGCAGUGGCCAGAUCCAGCUUUGGCA APTPAASPGKAPTGSSR AGCTCCTGTCGGACAGCTCCAACTCCAGCTGCATC GUUCCUCCUGGAGCUCCUGUCGGACAGCU ACCTGGGAAGGCACCAACGGGGAGTTCAAGATG CCAACUCCAGCUGCAUCACCUGGGAAGGCA A CCAACGGGGAGUUCAAGAUGA 29 279/578 ATGGGAAGCGCTACGCCTACAAGTTCGACTTCCAC AUGGGAAGCGCUACGCCUACAAGUUCGAC MGSATPTSSTSTGSPRPSSPTPRSHLCTST GGGATCGCCCAGGCCCTCCAGCCCCACCCCCCGG UUCCACGGGAUCGCCCAGGCCCUCCAGCCC PQTSRTWAPITPTHRR AGTCATCTCTGTACAAGTACCCCTCAGACCTCCCG CACCCCCCGGAGUCAUCUCUGUACAAGUAC TACATGGGCTCCTATCACGCCCACCCACAGAAGAT CCCUCAGACCUCCCGUACAUGGGCUCCUAU GA CACGCCCACCCACAGAAGAUGA 30 280/579 TTGCTGCCCCAAACCCATACTGGAATTCACCAACT UUGCUGCCCCAAACCCAUACUGGAAUUCAC LLPQTHTGIHQLGVYTPTLGSPPAICLLIW GGGGGTATATACCCCAACACTAGGCTCCCCACCA CAACUGGGGGUAUAUACCCCAACACUAGG ALTTKDLAEAFPISVHSPAHRHKLYRRT GCCATATGCCTTCTCATCTGGGCACTTACTACTAA CUCCCCACCAGCCAUAUGCCUUCUCAUCUG AGACCTGGCGGAGGCTTTTCCCATCAGCGTGCATT GGCACUUACUACUAAAGACCUGGCGGAGG CACCAGCCCATCGCCACAAACTCTATCGGAGAACA CUUUUCCCAUCAGCGUGCAUUCACCAGCCC TGA AUCGCCACAAACUCUAUCGGAGAACAUGA 31 281/580 ATGAAAAAAGCTTTACTGGGGCTGGGGAAGGAA AUGAAAAAAGCUUUACUGGGGCUGGGGAA MKKALLGLGKEAGEEIQRLLGGSY GCCGGGGAAGAGATCCAAAGACTCTTGGGAGGG GGAAGCCGGGGAAGAGAUCCAAAGACUCU AGTTACTGA UGGGAGGGAGUUACUGA 32 282/581 ATGAGGAGGATGCTAAAAATGTCACGAATATGGA AUGAGGAGGAUGCUAAAAAUGUCACGAAU MRRMLKMSRIWTYHLWTDLVKDSVCRS CATATCATCTGTGGACTGACCTTGTAAAAGACAGT AUGGACAUAUCAUCUGUGGACUGACCUUG MKS GTATGTAGAAGCATGAAGTCTTAA UAAAAGACAGUGUAUGUAGAAGCAUGAAG UCUUAA 33 283/582 CTGTATTTAAAAATAGAAACATATCAAAAACAAGA CUGUAUUUAAAAAUAGAAACAUAUCAAAA LYLKIETYQKQEKRHERDCGPSTDVDMQ GAAAAGACACGAGAGAGACTGTGGCCCATCAACA ACAAGAGAAAAGACACGAGAGAGACUGUG LHGMCCFG GACGTTGATATGCAACTGCATGGCATGTGCTGTTT GCCCAUCAACAGACGUUGAUAUGCAACUG TGGTTGA CAUGGCAUGUGCUGUUUUGGUUGA 34 284/583 GTGATTGTAGACAGAGGGGTGAAGAAGGAGGAG GUGAUUGUAGACAGAGGGGUGAAGAAGG VIVDRGVKKEEEEAEKEETRAGKETSQA GAAGAGGCAGAGAAGGAGGAGACCAGGGCTGG AGGAGGAAGAGGCAGAGAAGGAGGAGACC MKTGLRTFGDCVQ GAAAGAAACTTCTCAAGCAATGAAGACTGGACTC AGGGCUGGGAAAGAAACUUCUCAAGCAAU AGGACATTTGGGGACTGTGTACAATGA GAAGACUGGACUCAGGACAUUUGGGGACU GUGUACAAUGA 35 285/584 ATGGAGAAAGGGGAAGTAGTAGAATTCAGAAAC AUGGAGAAAGGGGAAGUAGUAGAAUUCA MEKGEVVEFRNKNAHLFLCLSNENFNW AAAAATGCGCATCTCTTTCTTTGTTTGTCAAATGAA GAAACAAAAAUGCGCAUCUCUUUCUUUGU NCLIFKRNIQDLIIMWGLCSPQGQVRDG AATTTTAACTGGAATTGTCTGATATTTAAGAGAAA UUGUCAAAUGAAAAUUUUAACUGGAAUU LLGCHNQKSRRHFG CATTCAGGACCTCATCATTATGTGGGGGCTTTGTT GUCUGAUAUUUAAGAGAAACAUUCAGGAC CTCCACAGGGTCAGGTAAGAGATGGCCTTCTTGG CUCAUCAUUAUGUGGGGGCUUUGUUCUC CTGCCACAATCAGAAATCACGCAGGCATTTTGGGT CACAGGGUCAGGUAAGAGAUGGCCUUCUU AG GGCUGCCACAAUCAGAAAUCACGCAGGCA UUUUGGGUAG 36 286/585 TTGAGTCGCGAACGCTGTGCGTTTGTCAGAATGA UUGAGUCGCGAACGCUGUGCGUUUGUCA LSRERCAFVRMKYTSQCFSPFLYNNYITY AGTATACAAGTCAATGTTTTTCCCCCTTTTTATATA GAAUGAAGUAUACAAGUCAAUGUUUUUCC AFIHYELISASQRHTTKETIDIMWP ATAATTATATAACTTATGCATTTATACACTACGAGT CCCUUUUUAUAUAAUAAUUAUAUAACUUA TGATCTCGGCCAGCCAAAGACACACGACAAAAGA UGCAUUUAUACACUACGAGUUGAUCUCGG GACAATCGATATAATGTGGCCTTGA CCAGCCAAAGACACACGACAAAAGAGACAA UCGAUAUAAUGUGGCCUUGA 37 287/586 TTGCCTCCCCTCCTGTCTTTTATTTCTAGCCCCTTTT UUGCCUCCCCUCCUGUCUUUUAUUUCUAG LPPLLSFISSPFWNRRTPGFTLEPPYLCLE GGAACAGAAGGACCCCGGGTTTCACATTGGAGCC CCCCUUUUGGAACAGAAGGACCCCGGGUU WKEAYEAGVVIEKF TCCATATTTATGCCTGGAATGGAAAGAGGCCTATG UCACAUUGGAGCCUCCAUAUUUAUGCCUG AAGCTGGGGTTGTCATTGAGAAATTCTAG GAAUGGAAAGAGGCCUAUGAAGCUGGGG UUGUCAUUGAGAAAUUCUAG 38 288/587 CTGCAATTTCTCACTTTACAGAAACAAGGGATAAC CUGCAAUUUCUCACUUUACAGAAACAAGG LQFLTLQKQGITSRFAAGFLFQELSLGRQL GTCTAGATTTGCTGCGGGGTTTCTCTTTCAGGAGC GAUAACGUCUAGAUUUGCUGCGGGGUUU TCTCACTAGGTAGACAGCTTTAG CUCUUUCAGGAGCUCUCACUAGGUAGACA GCUUUAG 39 289/588 CTGGCAGTTAGGCTGACCCAAACTGTGCTAATGG CUGGCAGUUAGGCUGACCCAAACUGUGCU LAVRLTQTVLMEKISHFYFGMQSQDTPT AAAAGATCAGTCATTTTTATTTTGGAATGCAAAGT AAUGGAAAAGAUCAGUCAUUUUUAUUUU FFIEIHIYLDNHSVLSSRLSHEQDHKNKT CAAGACACACCTACATTCTTCATAGAAATACACAT GGAAUGCAAAGUCAAGACACACCUACAUU TTACTTGGATAATCACTCAGTTCTCTCTTCAAGACT CUUCAUAGAAAUACACAUUUACUUGGAUA GTCTCATGAGCAAGATCATAAAAACAAGACATGA AUCACUCAGUUCUCUCUUCAAGACUGUCU CAUGAGCAAGAUCAUAAAAACAAGACAUG A 40 290/589 TTGGATAACATGATAATACTGAGTTCCTTCAAATA UUGGAUAACAUGAUAAUACUGAGUUCCUU LDNMIILSSFKYIILKLFQNGINSLLLL CATAATTCTTAAATTGTTTCAAAATGGCATTAACTC CAAAUACAUAAUUCUUAAAUUGUUUCAAA TCTGTTACTGTTGTAA AUGGCAUUAACUCUCUGUUACUGUUGUA A 41 291/590 TTGCATGAACCTTTTCTCTCTGTTTGTCCCTGTCTCT UUGCAUGAACCUUUUCUCUCUGUUUGUCC LHEPFLSVCPCLLACPDVYSDSCTILLLLAR TGGCTTGCCCTGATGTATACTCAGACTCCTGTACA CUGUCUCUUGGCUUGCCCUGAUGUAUACU DLSSFLVFNWLSGLVCGKITKSQSRLCFCS ATCTTACTCCTGCTGGCAAGAGATTTGTCTTCTTTT CAGACUCCUGUACAAUCUUACUCCUGCUG CTTGTCTTCAATTGGCTTTCGGGCCTTGTATGTGGT GCAAGAGAUUUGUCUUCUUUUCUUGUCU AAAATCACCAAATCACAGTCAAGACTGTGTTTTTG UCAAUUGGCUUUCGGGCCUUGUAUGUGG TTCCTAG UAAAAUCACCAAAUCACAGUCAAGACUGU GUUUUUGUUCCUAG 42 292/591 ATGTCCCGGAGGGGTTCACAAAGTGCTTTGTCAG AUGUCCCGGAGGGGUUCACAAAGUGCUUU MSRRGSQSALSGLLQLEGSLLLLSLLHRC GACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTA GUCAGGACUGCUGCAGUUAGAAGGCUCAC GTCNPGAGAGGAAL AGCCTTCTGCACAGATGTGGCACCTGCAACCCAG UGCUUCUCCUAAGCCUUCUGCACAGAUGU GAGCAGGAGCCGGAGGAGCTGCCCTCTGA GGCACCUGCAACCCAGGAGCAGGAGCCGGA GGAGCUGCCCUCUGA 43 293/592 GTGCAGCAGAGATGGCTACAGCTCAGGAGCTGG GUGCAGCAGAGAUGGCUACAGCUCAGGAG VQQRWLQLRSWEGDGAQGKHRCSAAP GAAGGTGATGGGGCACAGGGAAAGCACAGATGT CUGGGAAGGUGAUGGGGCACAGGGAAAGC QSDPLPGEREENIF TCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAG ACAGAUGUUCUGCAGCGCCCCAAAGUGAC AAAGAGAAGAAAATATTTTTTAA CCAUUGCCUGGAGAAAGAGAAGAAAAUAU UUUUUAA 44(BSS) 294/593 ATGCAGTGTGGCCAAAGGCGGGAAGATGGTGGG AUGCAGUGUGGCCAAAGGCGGGAAGAUGG MQCGQRREDGGQPRHRWDELRQLHG CAGCCCAGACACCGTTGGGATGAACTACGGCAGC UGGGCAGCCCAGACACCGUUGGGAUGAAC GEAHATPKHDHERAQSYRASRNSPDECS TACATGGAGGAGAAGCACATGCCACCCCCAAACA UACGGCAGCUACAUGGAGGAGAAGCACAU VAKGGKMVGSPDTVGMNYGSYMEEKH TGACCACGAACGAGCGCAGAGTTATCGTGCCAGC GCCACCCCCAAACAUGACCACGAACGAGCG MPPPNMTTNERRVIVPA AGGAACTCTCCTGATGAATGCAGTGTGGCCAAAG CAGAGUUAUCGUGCCAGCAGGAACUCUCC GCGGGAAGATGGTGGGCAGCCCAGACACCGTTG UGAUGAAUGCAGUGUGGCCAAAGGCGGGA GGATGAACTACGGCAGCTACATGGAGGAGAAGC AGAUGGUGGGCAGCCCAGACACCGUUGGG ACATGCCACCCCCAAACATGACCACGAACGAGCG AUGAACUACGGCAGCUACAUGGAGGAGAA CAGAGTTATCGTGCCAGCA GCACAUGCCACCCCCAAACAUGACCACGAA CGAGCGCAGAGUUAUCGUGCCAGCA 45(BSS) 295/594 GTGGCCAAAGGCGGGAAGATGGTGGGCAGCCCA GUGGCCAAAGGCGGGAAGAUGGUGGGCA VAKGGKMVGSPDTVGMNYGSYMEEKH GACACCGTTGGGATGAACTACGGCAGCTACATGG GCCCAGACACCGUUGGGAUGAACUACGGC MPPPNMTTNERRVIVPAGTLLMNAVW AGGAGAAGCACATGCCACCCCCAAACATGACCAC AGCUACAUGGAGGAGAAGCACAUGCCACCC PKAGRWWAAQTPLG GAACGAGCGCAGAGTTATCGTGCCAGCAGGAACT CCAAACAUGACCACGAACGAGCGCAGAGUU CTCCTGATGAATGCAGTGTGGCCAAAGGCGGGAA AUCGUGCCAGCAGGAACUCUCCUGAUGAA GATGGTGGGCAGCCCAGACACCGTTGGGATGA UGCAGUGUGGCCAAAGGCGGGAAGAUGG UGGGCAGCCCAGACACCGUUGGGAUGA 46 296/595 ATGGAGTACAGACCATGTGCGGCAGTGGCTGGA AUGGAGUACAGACCAUGUGCGGCAGUGGC MEYRPCAAVAGVGGERIWPSRRQHLVIP (BSS+RCA) GTGGGCGGTGAAAGAATATGGCCTTCCAGACGTC UGGAGUGGGCGGUGAAAGAAUAUGGCCU EHRWEGTVQDDQGRLPEAHPQLQRRH AACATCTTGTTATTCCAGAACATCGATGGGAAGGA UCCAGACGUCAACAUCUUGUUAUUCCAGA PSLTSPLPQRESYAMEYRPCAAVAGVGG ACTGTGCAAGATGACCAAGGACGACTTCCAGAGG ACAUCGAUGGGAAGGAACUGUGCAAGAUG ERIWPSRRQHLVIPEHRWEGTVQDDQG CTCACCCCCAGCTACAACGCCGACATCCTTCTCTCA ACCAAGGACGACUUCCAGAGGCUCACCCCC RLPEAHPQLQRRHPSLTSPLPQR CATCTCCACTACCTCAGAGAGAATCCTACGCTATG AGCUACAACGCCGACAUCCUUCUCUCACAU GAGTACAGACCATGTGCGGCAGTGGCTGGAGTG CUCCACUACCUCAGAGAGAAUCCUACGCUA GGCGGTGAAAGAATATGGCCTTCCAGACGTCAAC UGGAGUACAGACCAUGUGCGGCAGUGGCU ATCTTGTTATTCCAGAACATCGATGGGAAGGAACT GGAGUGGGCGGUGAAAGAAUAUGGCCUU GTGCAAGATGACCAAGGACGACTTCCAGAGGCTC CCAGACGUCAACAUCUUGUUAUUCCAGAA ACCCCCAGCTACAACGCCGACATCCTTCTCTCACAT CAUCGAUGGGAAGGAACUGUGCAAGAUGA CTCCACTACCTCAGAGA CCAAGGACGACUUCCAGAGGCUCACCCCCA GCUACAACGCCGACAUCCUUCUCUCACAUC UCCACUACCUCAGAGA 47 297/596 GTGCGGCAGTGGCTGGAGTGGGCGGTGAAAGAA GUGCGGCAGUGGCUGGAGUGGGCGGUGA VRQWLEWAVKEYGLPDVNILLFQNIDGK (BSS+RCA) TATGGCCTTCCAGACGTCAACATCTTGTTATTCCA AAGAAUAUGGCCUUCCAGACGUCAACAUC ELCKMTKDDFQRLTPSYNADILLSHLHYL GAACATCGATGGGAAGGAACTGTGCAAGATGACC UUGUUAUUCCAGAACAUCGAUGGGAAGGA RENPTLWSTDHVRQWLEWAVKEYGLPD AAGGACGACTTCCAGAGGCTCACCCCCAGCTACA ACUGUGCAAGAUGACCAAGGACGACUUCC VNILLFQNIDGKELCKMTKDDFQRLTPSY ACGCCGACATCCTTCTCTCACATCTCCACTACCTCA AGAGGCUCACCCCCAGCUACAACGCCGACA NADILLSHLHYLRE GAGAGAATCCTACGCTATGGAGTACAGACCATGT UCCUUCUCUCACAUCUCCACUACCUCAGAG GCGGCAGTGGCTGGAGTGGGCGGTGAAAGAATA AGAAUCCUACGCUAUGGAGUACAGACCAU TGGCCTTCCAGACGTCAACATCTTGTTATTCCAGA GUGCGGCAGUGGCUGGAGUGGGCGGUGA ACATCGATGGGAAGGAACTGTGCAAGATGACCAA AAGAAUAUGGCCUUCCAGACGUCAACAUC GGACGACTTCCAGAGGCTCACCCCCAGCTACAAC UUGUUAUUCCAGAACAUCGAUGGGAAGGA GCCGACATCCTTCTCTCACATCTCCACTACCTCAGA ACUGUGCAAGAUGACCAAGGACGACUUCC GAG AGAGGCUCACCCCCAGCUACAACGCCGACA UCCUUCUCUCACAUCUCCACUACCUCAGAG AG 48 298/597 TTGACTTCAGATGATGTTGATAAAGCCTTACAAAA UUGACUUCAGAUGAUGUUGAUAAAGCCU LTSDDVDKALQNSPRLMHARNTAPLPHL (BSS+RCA) CTCTCCACGGTTAATGCATGCTAGAAACACAGCTC UACAAAACUCUCCACGGUUAAUGCAUGCU TSDDVDKALQNSPRLMHARNT CTCTTCCACATTTGACTTCAGATGATGTTGATAAA AGAAACACAGCUCCUCUUCCACAUUUGAC GCCTTACAAAACTCTCCACGGTTAATGCATGCTAG UUCAGAUGAUGUUGAUAAAGCCUUACAAA AAACACA ACUCUCCACGGUUAAUGCAUGCUAGAAAC ACA 49 299/598 GTGCAGCTTTTATTTTCCCAAATACTTCAGTATATC GUGCAGCUUUUAUUUUCCCAAAUACUUCA VQLLFSQILQYILKLRKELQLGQGVQLLFS (BSS+RCA) CTGAAGCTACGCAAAGAATTACAACTAGGCCAGG GUAUAUCCUGAAGCUACGCAAAGAAUUAC QILQYILKLRKELQLGQ GGGTGCAGCTTTTATTTTCCCAAATACTTCAGTATA AACUAGGCCAGGGGGUGCAGCUUUUAUU TCCTGAAGCTACGCAAAGAATTACAACTAGGCCA UUCCCAAAUACUUCAGUAUAUCCUGAAGC G UACGCAAAGAAUUACAACUAGGCCAG

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