Compositions Comprising an Antimicrobial Boosting Agent

Abstract

The present invention relates to food, cosmetic or pharmaceutical preparations or homecare products comprising or consisting of a synergistic combination of an effective amount of an antimicrobial compound and an effective amount of a certain mycosporine-like amino acid compound. Additionally, the present invention relates to the use of such mycosporine-like amino acid compounds for boosting the efficacy of an antimicrobial compound. Finally, the present invention relates to a method for boosting the efficacy of an antimicrobial component comprising the admixing an antimicrobial compound with at least one of said mycosporine-like amino acid compound.

Claims

1. A food, cosmetic or pharmaceutical preparation or homecare product, comprising (a) at least one antimicrobial compound; and (b) at least one mycosporine-like amino acid compound, represented either by the general formula (V) ##STR00083## wherein Z is selected from the group consisting of OR2 or amide; R1 is selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted C(alkyl).sub.2, unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, halogen, O, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), unsubstituted or substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), and unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles; R2 is selected from the group consisting of H, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, and unsubstituted or substituted heteroaryl; amide is selected from the group consisting of NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, unsubstituted or substituted N(O-alkyl)(alkl) (Weinreb amide), N(OH)(H) (hydroxamate), and unsubstituted or substituted N(OH)(alkyl) (alkylated hydroxamate); R3 is selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; the substituents R4, R5 and R6 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, S(O).sub.2OH, sulfonyl, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; R7 and R8 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl) and unsubstituted or substituted NR9R10; R9 und R10 which may be identical or different, are independently from each other selected from the group consisting of H, OH, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, and unsubstituted or substituted heteroaryl; Y is selected from the group consisting of H and unsubstituted or substituted alkyl; and R is unsubstituted or substituted alkyl; or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds; or represented by the general formula (VI) ##STR00084## wherein R1 is selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted C(alkyl).sub.2, unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, halogen, O, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), unsubstituted or substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles; R2 is selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, C(O)-amide, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; X is selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted CH(alkenyl), unsubstituted or substituted CH(alkynyl), unsubstituted or substituted CH(alkoxy), unsubstituted or substituted CH(alkylthio), unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, O, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), unsubstituted or substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles; the substituents R4, R5 and R6 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, S(O).sub.2OH, sulfonyl, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; R7 and R8 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl) and unsubstituted or substituted NR9R10; amide is selected from the group consisting of NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, unsubstituted or substituted N(O-alkyl)(alkyl) (Weinreb amide), N(OH)(H) (hydroxamate), and unsubstituted or substituted-N(OH)(alkyl)(alkylated hydroxamate); R9 und R10 which may be identical or different, are independently from each other selected from the group consisting of H, OH, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocylcoalkyl, and unsubstituted or substituted heteroaryl; Y is selected from the group consisting of H and unsubstituted or substituted alkyl; and R is unsubstituted or substituted alkyl; or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds; or any mixture of the afore-mentioned compounds; with the proviso, that the following compounds are disclaimed/excluded: ##STR00085## ##STR00086##

2. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein the mycosporine-like amino acid compound (b) is represented either by the general formula (VII) ##STR00087## wherein R1, R2, R3, R4, R5 and R6 have the same meaning as defined for formula (V); or by the general formula (VII) ##STR00088## wherein R1, amide, R3, R4, R5 and R6 have the same meaning as defined for formula (V).

3. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein in the general formula (VI) X is selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted C(alkyl).sub.2, unsubstituted or substituted CH(alkenyl), unsubstituted or substituted CH(alkynyl), unsubstituted or substituted CH(alkoxy), unsubstituted or substituted CH(alkylthio), unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), unsubstituted or substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles

4. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein in the general formula (V) Z is OR2 or amide; and/or R1 is selected from the group consisting of CH.sub.2, C(alkyl).sub.2, O, S, SO, SO.sub.2, NH and N(alkyl); and/or R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, ##STR00089## (2-ethylhexyl) and phenyl; or amide is selected from the group consisting of NH.sub.2, NH(alkyl) and N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or the substituents R4, R5 and R6 have the same meaning as defined for formula (V); wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl; or wherein in the general formulae (VII) or (VIII) R1 is selected from the group consisting of CH.sub.2, C(alkyl).sub.2, O, S, SO, SO.sub.2, NH and N(alkyl); and/or R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, ##STR00090## (2-ethylhexyl) and phenyl; or amide is selected from the group consisting of NH.sub.2, NH(alkyl) and N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or the substituents R4, R5 and R6 have the same meaning as defined for formulae (VII) and (VIII); wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl; or wherein in the general formula (VI) R1 is selected from the group consisting of CH.sub.2, C(alkyl).sub.2, O, S, SO, SO.sub.2, NH and N(alkyl); and/or R2 is selected from the group consisting of CH.sub.2OH, C(O)OY, and C(O)-amide; and/or X is selected from the group consisting of CH.sub.2, CO, O, S, SO, SO.sub.2, NH, and N(alkyl); and/or Y is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, ##STR00091## (2-ethylhexyl) and phenyl; and/or amide is selected from the group consisting of NH.sub.2, NH(alkyl) and N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or the substituents R4, R5 and R6 have the same meaning as defined for formula (VI); wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

5. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein in the general formula (V) Z is OR2 or amide; and/or R1 is selected from the group consisting of CH.sub.2 and C(methyl).sub.2; and/or R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, ##STR00092## (2-ethylhexyl) and phenyl; or amide is selected from the group consisting of NH.sub.2, NH(alkyl) and N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or the substituents R4, R5 and R6 have the same meaning as defined for formula (V); wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl; or wherein in the general formulae (VII) or (VIII) R1 is selected from the group consisting of CH.sub.2, and C(methyl).sub.2; R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, ##STR00093## (2-ethylhexyl) and phenyl; or amide is selected from the group consisting of NH.sub.2, NH(alkyl) and N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or the substituents R4, R5 and R6 have the same meaning as defined for formulae (VII) and (VIII); wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl; and/or or wherein in the general formula (VI) R1 is selected from the group consisting of CH.sub.2 and C(methyl).sub.2; and/or R2 is selected from the group consisting of CH.sub.2OH, C(O)OY, and C(O)-amide; and/or X is selected from the group consisting of CH.sub.2, CO, O, S, SO, SO.sub.2, NH, and N(alkyl); and/or Y is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, ##STR00094## (2-ethylhexyl) and phenyl; and/or amide is selected from the group consisting of NH.sub.2, NH(alkyl) and N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or the substituents R4, R5 and R6 have the same meaning as defined for formula (VI); wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

6. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein the mycosporine-like amino acid compound (b) is selected from the group consisting of the following compounds I-1 to I-128 according to the general formula (V) and II-1 to II-192 according to the general formula (VI): TABLE-US-00043 R1 R3 Z I-1 CH2 H OR2 I-2 CH2 methyl OR2 I-3 CH2 ethyl OR2 I-4 CH2 O-methyl OR2 I-5 CH2 C(O)OH OR2 I-6 CH2 C(O)CH3 OR2 I-7 CH2 C(O)C3H7 OR2 I-8 CH2 C(O)O-methyl OR2 I-9 CH2 H amide I-10 CH2 methyl amide I-11 CH2 ethyl amide I-12 CH2 O-methyl amide I-13 CH2 C(O)OH amide I-14 CH2 C(O)CH3 amide I-15 CH2 C(O)C3H7 amide I-16 CH2 C(O)O-methyl amide I-17 C(methyl)2 H OR2 I-18 C(methyl)2 methyl OR2 I-19 C(methyl)2 ethyl OR2 I-20 C(methyl)2 O-methyl OR2 I-21 C(methyl)2 C(O)OH OR2 I-22 C(methyl)2 C(O)CH3 OR2 I-23 C(methyl)2 C(O)C3H7 OR2 I-24 C(methyl)2 C(O)O-methyl OR2 I-25 C(methyl)2 H amide I-26 C(methyl)2 methyl amide I-27 C(methyl)2 ethyl amide I-28 C(methyl)2 O-methyl amide I-29 C(methyl)2 C(O)OH amide I-30 C(methyl)2 C(O)CH3 amide I-31 C(methyl)2 C(O)C3H7 amide I-32 C(methyl)2 C(O)O-methyl amide I-33 O H OR2 I-34 O methyl OR2 I-35 O ethyl OR2 I-36 O O-methyl OR2 I-37 O C(O)OH OR2 I-38 O C(O)CH3 OR2 I-39 O C(O)C3H7 OR2 I-40 O C(O)O-methyl OR2 I-41 O H amide I-42 O methyl amide I-43 O ethyl amide I-44 O O-methyl amide I-45 O C(O)OH amide I-46 O C(O)CH3 amide I-47 O C(O)C3H7 amide I-48 O C(O)O-methyl amide I-49 S H OR2 I-50 S methyl OR2 I-51 S ethyl OR2 I-52 S O-methyl OR2 I-53 S C(O)OH OR2 I-54 S C(O)CH3 OR2 I-55 S C(O)C3H7 OR2 I-56 S C(O)O-methyl OR2 I-57 S H amide I-58 S methyl amide I-59 S ethyl amide' I-60 S O-methyl amide I-61 S C(O)OH amide I-62 S C(O)CH3 amide I-63 S C(O)C3H7 amide I-64 S C(O)O-methyl amide I-65 SO H OR2 I-66 SO methyl OR2 I-67 SO ethyl OR2 I-68 SO O-methyl OR2 I-69 SO C(O)OH OR2 I-70 SO C(O)CH3 OR2 I-71 SO C(O)C3H7 OR2 I-72 SO C(O)O-methyl OR2 I-73 SO H amide I-74 SO methyl amide I-75 SO ethyl amide I-76 SO O-methyl amide I-77 SO C(O)OH amide I-78 SO C(O)CH3 amide I-79 SO C(O)C3H7 amide I-80 SO C(O)O-methyl amide I-81 SO2 H OR2 I-82 SO2 methyl OR2 I-83 SO2 ethyl OR2 I-84 SO2 O-methyl OR2 I-85 SO2 C(O)OH OR2 I-86 SO2 C(O)CH3 OR2 I-87 SO2 C(O)C3H7 OR2 I-88 SO2 C(O)O-methyl OR2 I-89 SO2 H amide I-90 SO2 methyl amide I-91 SO2 ethyl amide I-92 SO2 O-methyl amide I-93 SO2 C(O)OH amide I-94 SO2 C(O)CH3 amide I-95 SO2 C(O)C3H7 amide I-96 SO2 C(O)O-methyl amide I-97 NH H OR2 I-98 NH methyl OR2 I-99 NH ethyl OR2 I-100 NH O-methyl OR2 I-101 NH C(O)OH OR2 I-102 NH C(O)CH3 OR2 I-103 NH C(O)C3H7 OR2 I-104 NH C(O)O-methyl OR2 I-105 NH H amide I-106 NH methyl amide I-107 NH ethyl amide I-108 NH O-methyl amide I-109 NH C(O)OH amide I-110 NH C(O)CH3 amide I-111 NH C(O)C3H7 amide I-112 NH C(O)O-methyl amide I-113 N(alkyl) H OR2 I-114 N(alkyl) methyl OR2 I-115 N(alkyl) ethyl OR2 I-116 N(alkyl) O-methyl OR2 I-117 N(alkyl) C(O)OH OR2 I-118 N(alkyl) C(O)CH3 OR2 I-119 N(alkyl) (CO)C3H7 OR2 I-120 N(alkyl) C(O)O-methyl OR2 I-121 N(alkyl) H amide I-122 N(alkyl) methyl amide I-123 N(alkyl) ethyl amide I-124 N(alkyl) O-methyl amide I-125 N(alkyl) C(O)OH amide I-126 N(alkyl) C(O)CH3 amide I-127 N(alkyl) C(O)C3H7 amide I-128 N(alkyl) C(O)O-methyl amide R1 X R2 II-1 CH2 CH2 CH2OH II-2 CH2 CO CH2OH II-3 CH2 O CH2OH II-4 CH2 S CH2OH II-5 CH2 SO CH2OH II-6 CH2 SO2 CH2OH II-7 CH2 NH CH2OH II-8 CH2 N(alkyl) CH2OH II-9 CH2 CH2 C(O)OY II-10 CH2 CO C(O)OY II-11 CH2 O C(O)OY II-12 CH2 S C(O)OY II-13 CH2 SO C(O)OY II-14 CH2 SO2 C(O)OY II-15 CH2 NH C(O)OY II-16 CH2 N(alkyl) C(O)OY II-17 CH2 CH2 C(O)- amide II-18 CH2 CO C(O)- amide II-19 CH2 O C(O)- amide II-20 CH2 S C(O)- amide II-21 CH2 SO C(O)- amide II-22 CH2 SO2 C(O)- amide II-23 CH2 NH C(O)- amide II-24 CH2 N(alkyl) C(O)- amide II-25 C(methyl)2 CH2 CH2OH II-26 C(methyl)2 CO CH2OH II-27 C(methyl)2 O CH2OH II-28 C(methyl)2 S CH2OH II-29 C(methyl)2 SO CH2OH II-30 C(methyl)2 SO2 CH2OH II-31 C(methyl)2 NH CH2OH II-32 C(methyl)2 N(alkyl) CH2OH II-33 C(methyl)2 CH2 C(O)OY II-34 C(methyl)2 CO C(O)OY II-35 C(methyl)2 O C(O)OY II-36 C(methyl)2 S C(O)OY II-37 C(methyl)2 SO C(O)OY II-38 C(methyl)2 SO2 C(O)OY II-39 C(methyl)2 NH C(O)OY II-40 C(methyl)2 N(alkyl) C(O)OY II-41 C(methyl)2 CH2 C(O)- amide II-42 C(methyl)2 CO C(O)- amide II-43 C(methyl)2 O C(O)- amide II-44 C(methyl)2 S C(O)- amide II-45 C(methyl)2 SO C(O)- amide II-46 C(methyl)2 SO2 C(O)- amide II-47 C(methyl)2 NH C(O)- amide II-48 C(methyl)2 N(alkyl) C(O)- amide II-49 O CH2 CH2OH II-50 O CO CH2OH II-51 O O CH2OH II-52 O S CH2OH II-53 O SO CH2OH II-54 O SO2 CH2OH II-55 O NH CH2OH II-56 O N(alkyl) CH2OH II-57 O CH2 C(O)OY II-58 O CO C(O)OY II-59 O O C(O)OY II-60 O S C(O)OY II-61 O SO (CO)OY II-62 O SO2 C(O)OY II-63 O NH C(O)OY II-64 O N(alkyl) C(O)OY II-65 O CH2 C(O)- amide II-66 O CO C(O)- amide II-67 O O (CO)- amide II-68 O S C(O)- amide II-69 O SO C(O)- amide II-70 O SO2 C(O)- amide II-71 O NH C(O)- amide II-72 O N(alkyl) C(O)- amide II-73 S CH2 CH2OH II-74 S CO CH2OH II-75 S O CH2OH II-76 S S CH2OH II-77 S SO CH2OH II-78 S SO2 CH2OH II-79 S NH CH2OH II-80 S N(alkyl) CH2OH II-81 S CH2 C(O)OY II-82 S CO C(O)OY II-83 S O C(O)OY II-84 S S C(O)OY II-85 S SO C(O)OY II-86 S SO2 C(O)OY II-87 S NH C(O)OY II-88 S N(alkyl) C(O)OY II-89 S CH2 C(O)- amide II-90 S CO C(O)- amide II-91 S O C(O)- amide II-92 S S C(O)- amide II-93 S SO C(O)- amide II-94 S SO2 C(O)- amide II-95 S NH C(O)- amide II-96 S N(alkyl) C(O)- amide II-97 SO CH2 CH2OH II-98 SO CO CH2OH II-99 SO O CH2OH II-100 SO S CH2OH II-101 SO SO CH2OH II-102 SO SO2 CH2OH II-103 SO NH CH2OH II-104 SO N(alkyl) CH2OH II-105 SO CH2 C(O)OY II-106 SO CO C(O)OY II-107 SO O C(O)OY II-108 SO S C(O)OY II-109 SO SO C(O)OY II-110 SO SO2 C(O)OY II-111 SO NH C(O)OY II-112 SO N(alkyl) C(O)OY II-113 SO CH2 C(O)- amide II-114 SO CO C(O)- amide II-115 SO O C(O)- amide II-116 SO S C(O)- amide II-117 SO SO C(O)- amide II-118 SO SO2 C(O)- amide II-119 SO NH C(O)- amide'' II-120 SO N(alkyl) C(O- amide II-121 SO2 CH2 CH2OH II-122 SO2 CO CH2OH II-123 SO2 O CH2OH II-124 SO2 S CH2OH II-125 SO2 SO CH2OH II-126 SO2 SO2 CH2OH II-127 SO2 NH CH2OH II-128 SO2 N(alkyl) CH2OH II-129 SO2 CH2 C(O)OY II-130 SO2 CO C(O)OY II-131 SO2 O C(O)OY II-132 SO2 S C(O)OY II-133 SO2 SO C(O)OY II-134 SO2 SO2 C(O)OY II-135 SO2 NH C(O)OY II-136 SO2 N(alkyl) C(O)OY II-137 SO2 CH2 C(O)- amide II-138 SO2 CO C(O)- amide II-139 SO2 O C(O)- amide II-140 SO2 S C(O)- amide II-141 SO2 SO C(O)- amide II-142 SO2 SO2 C(O)- amide II-143 SO2 NH C(O)- amide II-144 SO2 N(alkyl) C(O)- amide II-145 NH CH2 CH2OH II-146 NH CO CH2OH II-147 NH O CH2OH II-148 NH S CH2OH II-149 NH SO CH2OH II-150 NH SO2 CH2OH II-151 NH NH CH2OH II-152 NH N(alkyl) CH2OH II-153 NH CH2 C(O)OY II-154 NH CO C(O)OY II-155 NH O C(O)OY II-156 NH S C(O)OY II-157 NH SO C(O)OY II-158 NH SO2 C(O)OY II-159 NH NH C(O)OY II-160 NH N(alkyl) C(O)OY II-161 NH CH2 C(O)- amide II-162 NH CO C(O)- amide II-163 NH O C(O- amide II-164 NH S C(O- amide II-165 NH SO C(O)- amide II-166 NH SO2 C(O)- amide II-167 NH NH C(O)- amide II-168 NH N(alkyl) C(O)- amide II-169 N(alkyl) CH2 CH2OH II-170 N(alkyl) CO CH2OH II-171 N(alkyl) O CH2OH II-172 N(alkyl) S CH2OH II-173 N(alkyl) SO CH2OH II-174 N(alkyl) SO2 CH2OH II-175 N(alkyl) NH CH2OH II-176 N(alkyl) N(alkyl) CH2OH II-177 N(alkyl) CH2 C(O)OY II-178 N(alkyl) CO C(O)OY II-179 N(alkyl) O C(O)OY II-180 N(alkyl) S C(O)OY II-181 N(alkyl) SO C(O)OY II-182 N(alkyl) SO2 C(O)OY II-183 N(alkyl) NH C(O)OY II-184 N(alkyl) N(alky) C(O)OY II-185 N(alkyl) CH2 C(O)- amide II-186 N(alkyl) CO C(O)- amide II-187 N(alkyl) O C(O)- amide II-188 N(alkyl) S C(O)- amide II-189 N(alkyl) SO C(O)- amide II-190 N(alkyl) SO2 C(O)- amide II-191 N(alkyl) NH C(O)- amide II-192 N(alkyl) N(alkyl) C(O)- amide wherein in the above mycosporine-like amino acid compounds the phenyl ring may be unsubstituted or substituted, and R4, R5, R6, R4, R5, R6, amide, Y, amide and alkyl have the same meaning as defined in any one of the preceding claims, or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds; or wherein the mycosporine-like amino acid is selected from the group consisting of ##STR00097## wherein alkyl is either methyl or ethyl or propyl or isopropyl or butyl or isobutyl or tert-butyl, or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds; or any mixture of the afore-mentioned compounds.

7. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein in the general formulae (VI), X is S, SO or SO.sub.2, and/or wherein in the general formulae (V) to (VIII) n=1.

8. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein in the general formulae (V), (VII) and (VIII) the substituents R4, R5 and R6 which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, alkoxy, S(O).sub.2OH, and sulfonyl; or wherein in the general formulae (VI), the substituents R4, R5 and R6 which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, alkoxy, S(O).sub.2OH, and sulfonyl.

9. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein in the general formulae (V) to (VIII) the substituted phenyl bonded to the imino functionality is selected from the group consisting of ##STR00098## wherein the dotted line designates the binding site.

10. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein in the general formulae (V), (VII) and (VIII) the substituents R4, R5, R6, which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, alkoxy, S(O).sub.2OH, and sulfonyl; with the proviso, that if the substituted phenyl ring is monosubstituted, the substituent is either in the ortho or meta-position to the imino-functionality; or wherein in the general formula (VI), the substituents R4, R5 and R6, which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, alkoxy, S(O).sub.2OH, and sulfonyl; with the proviso, that if the substituted phenyl ring is monosubstituted, the substituent is either in the ortho or meta-position to the imino-functionality of the general formulae (VI), but not in the para position to the imino-functionality.

11. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein the mycosporine-like amino acid compound is selected from the group consisting of TABLE-US-00044 Com- pound Structure INCI/chemical name MAA-1 ethyl 2-[[5,5-dimethyl-3- phenylimino-cyclohexen-1- yl]amino]acetate MAA-2 ethyl 2-((5,5-dimethyl-3-((4- octyoxy)phenyl)imino)cyclohex-1- en-1-yl)amino)acetate MAA-3 5,5-dimethyl-3-((4- (octyloxy)phenyl)imino)cyclohex-1- en-1-yl-glycine MAA-4 ethyl 2-((3-((4- benzoylphenyl)imino)-5,5- dimethylcyclohex-1-en-1- yl)amino)acetate MAA-5 3-((4-benzoylphenyl)imino)-5,5- dimethylcyclohex-1-en-1-yl-glycine MAA-6 ethyl 2-((3-([1,1-biphenyl]-4- ylimino)-5,5-dimethylcyclohex-1-en- 1.yl)amino)acetate MAA-7 3-([1,1-biphenyl]-4-ylimino)-5,5- dimethylcyclohex-1-en-1-yl-glycine MAA-8 ethyl 2-((5,5-dimethyl-3-((4- (phenyldiazenyl)phenyl)inino (cyclohex-1-en-1-yl)amino)acetate MAA-9 5,5-dimethyl-3-((4-((E)- phenyldiazenyl)phenyl)imino) cyclohex- 1-en-1-yl-glycine MAA-11 3-((4-fluorophenyl)imino)-5,5- dimethylcyclohex-1-en-1-yl-glycine MAA-12 ethyl 8-((3,4- dimethoyxphenyl)imino)-6,6- dimethyl-3,4,5,6,7,8-hexahydro-2-H- benzol[b][1,4]thiazine-3-carboxylate MAA-13 8-((3,4-dimethoyxphenyl)imino)-6,6- dimethyl-3,4,5,6,7,8-hexahydro-2-H- benzol[b][1,4]thiazine-3-carboxylic acid MAA-14 ethyl 2-((3-((3,4- dimethoxyphenyl)imino)-5,5- dimethylcyclohex-1-en-1- yl)amino)acetate MAA-16 ethyl 2-((5,5-dimethyl-3-((4- morpholinophenyl)imino)cyclohex- 1-en-1-yl)amino)acetate MAA-17 5,5-dimethyl-3-((4- morpholinophenyl)imino)cyclohex- 1-en-1-yl-glycine MAA-20 2-[(5,5-dimethyl-3-phenylimino- cyclohexen-1-yl)amino]acetic acid MAA-21 2-[(3-phenyliminocyclohexen-1- yl)amino]acetic acid MAA-22 2,5,5-trimethyl-3- (phenylimino)cyclohex-1-en-1-yl- glycine MAA-23 2-[(2-methyl-3-phenylimino- cyclohexen-1-yl)amino]acetic acid MAA-24 3-((3,4-dimethoxyphenyl)imino)-5,5- dimethylcyclohex-1-en-1-yl-glycine MAA-25 3-((3,4- dimethoxyphenyl)imino)cyclohex-1- en-1-yl-glycine MAA-26 3-((3,4-dimethoxyphenyl)imino)- 2,5,5-trimethylcyclohex-1-en-1-yl- glycine MAA-27 2-[(3-(3,4-dimethoxyphenyl)imino-2- methyl-cyclohexen-1-yl)amino]acetic acid MAA-28 2-[(5,5-dimethyl-3-(4- sulfophenyl)imino-cyclohexen-1- yl)amino]acetic acid MAA-29 2-[(3-(4- sulfophenyl)iminocyclohexen-1- yl)amino]acetic acid MAA-30 2,5,5-trimethyl-3-((4- sulfophenyl)imino)cyclohex-1-en-1- yl-glycine MAA-31 2-methyl-3-((4- sulfophenyl)imino)cyclohex-1-en-1- yl-glycine MAA-32 2-[(5,5-dimethyl-3-phenylimino- cyclohexen-1-yl)amino]acetamide MAA-33 2-[(3-phenyliminocyclohexen-1- yl)amino]acetamide MAA-34 2-((2,5,5-trimethyl-3- (phenylimino)cyclohex-1-en-1- yl)amino)acetamide MAA-35 2-((2-methyl-3- (phenylimino)cyclohex-1-en-1- yl)amino)acetamide MAA-36 2-((3-((3,4-dimethoxyphenyl)imino)- 5,5-dimethylcyclohex-1-en-1- yl)amino)acetamide MAA-37 2-[(3-(3,4- dimethoxyphenyl)iminocyclohexen- 1-yl)amino]acetamide MAA-38 2-((3-((3,4-dimethoxyphenyl)imino)- 2,5,5-trimethylcyclohex-1-en-1- yl)amino)acetamide MAA-39 2-((3-((3,4-dimethoxyphenyl)imino)- 2-methylcyclohex-1-en-1- yl)amino)acetamide or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds; or any mixture of the afore-mentioned compounds.

12. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, wherein the at least one antimicrobial compound is selected from the group consisting of Caprylhydroxamic Acid, o-Cymen-5-ol, Isopropylparaben, Capryloyl Glycine, Phenylpropanol, Tropolone, PCA Ethyl Cocoyl Arginate, 2-Methyl 5-Cyclohexylpentanol, Phenoxyethanol, Disodium EDTA, Cetrimonium Chloride, Methylparaben and its salts, Sodium Benzoate, Benzyl Alcohol, Potassium Sorbate, Benzyl Salicylate, Propylparaben, Sodium Methylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Sodium Propylparaben, DMDM Hydantoin, Dehydroacetic Acid, Salicylic Acid, Chlorphenesin, Isobutylparaben, Sodium Ethylparaben, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bisabolol, Formic acid and its salts, Glyceryl Caprylate, Sodium Phytate or Phytic Acid, Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its salts, Chlorhexidine Digluconate, TEA-salicylate, Phenethyl Alcohol, Glyceryl Caprate, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate, Trisodium Ethylenediamine Disuccinate, Hydroxyethoxyphenyl Butanone, Hydroxyethoxyphenyl Butanol, Itaconic Acid, Octopirox, Propanediol Caprylate, Climbazole, Undecylenoyl Glycine, Thymol, 4-Hydroxyacetophenone, Lactic Acid, Sodium Lactate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, Benzoesure-3-hydroxypropylester, and mixtures of two or more the aforesaid antimicrobial compounds.

13. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 12, wherein the antimicrobial agent is selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2-benzylheptanol, 2-hydroxyacetophenone, 2-methyl 5-cyclohexylpentanol, 3-hydroxypropyl 2-hydroxybenzoate, 4-hydroxyacetophenone, and any mixture thereof.

14. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, further comprising at least one additional antimicrobial agent, which is different from the at least one antimicrobial compound, selected from the group consisting of 2-benzylheptanol, alkyl (C 12-22) trimethyl ammonium bromide and chloride, ascorbic acid and salts thereof, benzalkonium bromide, benzalkonium chloride, benzalkonium saccharinate, benzethonium chloride, Benzoic Acid, camphor, cetylpyridinium chloride, chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorocresol, chloroxylenol, Cyclohexylglycerin, Chlorobutanol, Carvacrol, Dimethyl phenylbutanol, Dimethyl phenylpropanol, ethanol, ethyl lauroyl arginate HCl, Ethyl Lauroyl Arginate Laurate, eucalyptol, gluconic acid and salts thereof, glycerin, hexamidine, hexamidine diisethionate, Hexylglycerin, Iodopropynyl Butylcarbamate, jasmol, lauryl alcohol, Levulinic Acid and esters and/or ketals thereof, mannitol, menthol, methyl salicylate, Octenidine HCl, polyarginine, Polyglyceryl-10 Laurate, polyglyceryl-2 caprate, Polyglyceryl-3 caprylate, polylysine, Salvia Officinalis (Sage) Oil, silver chloride, silver citrate, sodium caproyl lactylate, Sodium Caproyl/Lauroyl Lactylate, sodium lauroyl lactylate, Sorbic Acid, sorbitol, Tetraselmis extract, triclocarban, triclosan, Triethyl citrate, Xylityl Sesquicaprylate, zinc citrate, zinc pyrithione, Zinc ricinoleate, and mixtures of two or more of the aforesaid antimicrobial agents.

15. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, comprising the at least one antimicrobial compound (a) or a mixture thereof in an amount of 0.0001 to 10.0% by weight, based on the total weight of the composition or product.

16. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, comprising the mycosporine-like amino acid compound or a mixture thereof in an amount of 0.001 to 15.0% by weight, based on the total weight of the composition or product.

17. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, further comprising at least one 1,2-alkanediol or 2,3-alkanediol with 5 to 12 carbon atoms, wherein the 1,2-alkanediol is preferably-selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, and wherein the 2,3-alkaediol is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and any mixture thereof.

18. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1, further comprising at least one excipient and/or active substance selected from the group consisting of agents against ageing of the skin, antioxidants, emulsifiers, preservatives, UV-filters, silicones, chelating agents, surfactants, green and synthetic polymers, skin-cooling agents, rheology additives, oils, carriers and hydrotropes, fragrances or perfume oils, and any mixture of two or more of the afore-mentioned substances.

19. The food, cosmetic or pharmaceutical preparation or homecare product according to claim 1 in the form of (i) a dispersion; (ii) a liquid surfactant formulation; (iii) a solid surfactant formulation; (iv) a water free formulation; or (v) an aqueous, aqueous/alcoholic, aqueous/glycolic, or alcoholic/glycolic solution.

20-22. (canceled)

23. A method for boosting the efficacy of an antimicrobial compound comprising mixing the antimicrobial compound with an effective amount of at least one mycosporine-like amino acid compound.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0040] In the context of the present invention, the following general meanings apply:

[0041] As used herein, the singular form a, a and the include plural references unless the context clearly dictates otherwise. Thus, for example reference to cosmetic preparation, the cosmetic preparation or a cosmetic preparation also includes a plurality of cosmetic preparations.

[0042] The terms comprising, including, and containing are to be understood as open-ended terms and mean that the named components following said term are essential but not limited to, and other components may be added and are still embraced by the present invention.

[0043] The term consisting of as used according to the present invention means that the total amount of components (a) and (b) adds up to 100% by weight, based on the total weight of the sunscreen product or cosmetic or pharmaceutical preparation, and signifies that the subject matter is closed-ended and can only include the limitations that are expressly recited.

[0044] Whenever reference is made to comprising it is intended to cover both meanings as alternatives, that is the meaning can be either comprising or consisting of unless the context dictates otherwise.

[0045] The term optionally means that the subsequently described compound may but need not to be present in the composition, and that the description includes variants, where the compound is included or variants, where the compound is absent.

[0046] The term or or and/or is used as a function word to indicate that two words or phrases are to be taken together or separately.

[0047] The endpoints of all ranges directed to the same component or property are inclusive and independently combinable.

[0048] The term compound(s) or compound(s) of the present invention refers to all compounds encompassed by the structural formulae (V) and/or formula (VI) and/or formula (VII) and/or formula (XIII) and/or formula (IX) and/or formula (X) and their sub-formulae disclosed herein and includes each subgenus and all specific compounds within the formula whose structure is disclosed herein.

[0049] The compounds may be identified by either their chemical structure and/or chemical name. When the chemical structure and chemical name are in conflict, the chemical structure determines the identity of the compound.

[0050] The term at least one . . . compound means that the food, cosmetic cor pharmaceutical preparation or homecare product according to the present invention, in the following also referred to as composition, can comprise either one of said subsequently described individual compound or a mixture of two, three, four, five, six or even more different of said subsequently compounds.

[0051] The term effective amount of a compound means the amount of compound, that is sufficient to achieve the desired effect or improvement. For example: the effective amount of an antimicrobial means the amount or concentration of an antimicrobial, that is sufficient to result in an antimicrobial efficacy.

[0052] The term antimicrobial effect in the context of the present invention means that the microorganisms' growth is reduced or even inhibited, so that the number of living microorganisms is reduced or that microorganisms' growth does not arise.

[0053] The term synergistic effect is an effect achieved when two different chemical substances or biological structures interact resulting in 8rylthiol88e overall effect that is greater than the sum of individual effects of any of them. In the present invention, the synergistic effect relates to a synergistic antimicrobial effect.

[0054] The term food in the context of the present invention is any substance or formulation consumed to provide nutritional support for an organism. Food is usually of plant, animal, or fungal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins or minerals. The substance or formulation is ingested by an organism and assimilated by the organism's cells to provide energy, maintain life, or stimulate growth. The term food also encompass food for animals.

[0055] The term cosmetic or pharmaceutical preparations in the context of the present invention are compositions for cosmetic or pharmaceutical purposes. The term cosmetic or pharmaceutical preparations also encompasses sunscreen products, i.e. a photoprotective topical product for the skin including UV-filter compounds that absorbs or reflects some of the sun's ultraviolet (UV) radiation and thus helps protect against sunburn and most importantly prevent skin cancer.

[0056] A sunscreen product in the context of the present invention, also known as sunblock, sun cream or suntan lotion, is a photoprotective topical product for the skin including UV-filter compounds that absorbs or reflects some of the sun's ultraviolet (UV) radiation and thus helps protect against sunburn and most importantly prevent skin cancer. Sunscreens come as lotions, sprays, gels, foams (such as an expanded foam lotion or whipped lotion), sticks, powders and other topical products. UV-absorbing compounds are used not only in sunscreen, but also in other personal care products, such as lipstick, shampoo, hair spray, body wash, toilet soap, and insect repellent.

[0057] The term homecare products in the context of the present invention are the essentials for daily care and cleaning purpose in households. They are used for maintaining hygiene and a good aura of the homes. The home care products generally include laundry detergents (powder, liquid and tablet), fabric conditioners, dishwashing detergents (liquid and tablet), hard floor and surface cleaners, glass cleaners, carpet cleaners, oven cleaners, air fresheners, disinfectants, stain removers, car wash products. These products are usually manufactured in the form of a liquid, powder, spray, granules and others. The sunscreen containing formulations prevent premature photodamage and photobleaching to surfaces and the homecare formulation itself.

[0058] According to the present invention, the primary object of the present invention is solved by a food, cosmetic, especially dermatological, or pharmaceutical preparation or homecare product, comprising or consisting of [0059] (a) at least one antimicrobial compound; and [0060] (b) at least one mycosporine-like amino acid compound, [0061] represented either by the general formula (V)

##STR00003## [0062] wherein [0063] Z is selected from the group consisting of OR2 or amide; [0064] R1 is selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted C(alkyl).sub.2, unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, halogen, O, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), unsubstituted or substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), and unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles; [0065] R2 is selected from the group consisting of H, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl; [0066] amide is selected from the group consisting of NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), and unsubstituted or substituted NR9R10, unsubstituted or substituted-N(O-alkyl)(alkl) (Weinreb amide), N(OH)(H) (hydroxamate), and unsubstituted or substituted-N(OH)(alkyl) (alkylated hydroxamate); [0067] R3 is selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; [0068] the substituents R4, R5 and R6 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, S(O).sub.2OH, sulfonyl, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), and unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; [0069] R7 and R8 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl) and unsubstituted or substituted NR9R10; [0070] R9 und R10 which may be identical or different, are independently from each other selected from the group consisting of H, OH, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, and unsubstituted or substituted heteroaryl; [0071] Y is selected from the group consisting of H and unsubstituted or substituted alkyl; and [0072] R is unsubstituted or substituted alkyl; [0073] or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds; [0074] or represented by the general formula (VI)

##STR00004## [0075] wherein [0076] R1 is selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted C(alkyl).sub.2, unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, halogen, O, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles; [0077] R2 is selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, C(O)-amide, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; [0078] X is selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted CH(alkenyl), unsubstituted or substituted CH(alkynyl), unsubstituted or substituted CH(alkoxy), unsubstituted or substituted CH(alkylthio), unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, O, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), unsubstituted or substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles; [0079] the substituents R4, R5 and R6 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, S(O).sub.2OH, sulfonyl, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), and unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, and unsubstituted or substituted C-spirocycles; [0080] R7 and R8 which may be identical or different, are independently from each other selected from the group consisting of H, OH, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), CH.sub.2OH, RCH.sub.2OH, C(O)OY, RC(O)OY, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, SO, SO.sub.2, NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl) and unsubstituted or substituted NR9R10; [0081] amide is selected from the group consisting of NH.sub.2, unsubstituted or substituted NH(alkyl), unsubstituted or substituted NH(alkenyl), unsubstituted or substituted NH(alkynyl), unsubstituted or substituted NH(alkoxy), unsubstituted or substituted NH(alkylthio), unsubstituted or substituted NH(cycloalkyl), unsubstituted or substituted NH(aryl), unsubstituted or substituted NH(heterocycloalkyl), unsubstituted or substituted NH(heteroaryl), unsubstituted or substituted NR9R10, unsubstituted or substituted-N(O-alkyl)(alkyl) (Weinreb amide), N(OH)(H) (hydroxamate), and unsubstituted or substituted-N(OH)(alkyl) (alkylated hydroxamate); [0082] R9 und R10 which may be identical or different, are independently from each other selected from the group consisting of H, OH, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted alkoxy, unsubstituted or substituted alkylthio, unsubstituted or substituted alkanoyl/acyl RC(O), unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocylcoalkyl, and unsubstituted or substituted heteroaryl; [0083] Y is selected from the group consisting of H and unsubstituted or substituted alkyl; and [0084] R is unsubstituted or substituted alkyl; [0085] or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds; [0086] or any mixture of the afore-mentioned compounds.

[0087] The component (a) of the food, cosmetic or pharmaceutical preparation or homecare product according to the first aspect of the present invention relates to an antimicrobial compound or substance, which is commonly used in many food, cosmetic preparations, in particular skincare, haircare or body care, or in pharmaceutical preparations or homecare products.

[0088] The term antimicrobial compound in the context of the present invention refers to a group of substances, in particular to an agent that kills microorganisms or stops or inhibits their growth. Antimicrobial agents can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, antifungals are used against fungi, antiprotozoals are used against protozoans, and antivirals are used against virus. They can also be classified according to their function. Agents that kill microbes are biocidal or microbicidal, while those that merely inhibit their growth are called biostatic.

[0089] The antimicrobial compound (a) according to the present invention act primarily against microorganisms, in particular bacteria, yeast and/or fungi. Specified microorganisms are aerobic mesophilic bacteria or yeast or fungi undesirable in a cosmetic product and recognised as a skin pathogen species that may be harmful for human health or as an indication of hygienic failure in the manufacturing process. Microorganisms considered as specified microorganisms according to the present invention are of the genus Pseudomonas (bacterium), Staphylococcus (bacterium), Escherichia (bacterium), Candida (yeast) and Aspergillus (fungi), and combinations thereof.

[0090] More preferably, the microorganisms are selected from the group consisting of Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus brasiliensis, and combinations thereof.

[0091] The composition according to the first aspect of the present invention encompasses at least one antimicrobial active compound (a) selected from the group consisting of Caprylhydroxamic Acid, o-Cymen-5-ol, Isopropylparaben, Capryloyl Glycine, Phenylpropanol, Tropolone, PCA Ethyl Cocoyl Arginate, 2-Methyl 5-Cyclohexylpentanol, Phenoxyethanol, Disodium EDTA, Cetrimonium Chloride, Methylparaben and its salts, Sodium Benzoate, Benzyl Alcohol, Potassium Sorbate, Benzyl Salicylate, Propylparaben, Sodium Methylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Sodium Propylparaben, DMDM Hydantoin, Dehydroacetic Acid, Salicylic Acid, Chlorphenesin, Isobutylparaben, Sodium Ethylparaben, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bisabolol, Formic acid and its salts, Glyceryl Caprylate, Sodium Phytate or Phytic Acid, Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its salts, Chlorhexidine Digluconate, TEA-salicylate, Phenethyl Alcohol, Glyceryl Caprate, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate, Trisodium Ethylenediamine Disuccinate, Hydroxyethoxyphenyl Butanone, Hydroxyethoxyphenyl Butanol, Itaconic Acid, Octopirox, Propanediol Caprylate, Climbazole, Undecylenoyl Glycine, Thymol, 4-Hydroxyacetophenone, Lactic Acid, Sodium Lactate, Trisodium Dicarboxymethyl Alaninate, Frambinon, Xylityl caprylate, Benzoic acid 3-hyroxypropylester, Anisic acid 3-hydroxypropylester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, Benzoesure-3-hydroxypropylester, and mixtures of two or more the aforesaid antimicrobial components.

[0092] In a preferred variant, the antimicrobial active compound (a) is selected from the group consisting of Caprylhydroxamic Acid, o-Cymen-5-ol, Isopropylparaben, Capryloyl Glycine, Phenylpropanol, Tropolone, PCA Ethyl Cocoyl Arginate, 2-Methyl 5-Cyclohexylpentanol, Phenoxyethanol, Disodium EDTA, Methylparaben and its salts, Sodium Benzoate, Benzyl Alcohol, Potassium Sorbate, Benzyl Salicylate, Propylparaben, Sodium Methylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Sodium Propylparaben, DMDM Hydantoin, Dehydroacetic Acid, Salicylic Acid, Chlorphenesin, Isobutylparaben, Sodium Ethylparaben, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Glyceryl Caprylate, Sodium Phytate or Phytic Acid, Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its salts, Chlorhexidine Digluconate, TEA-salicylate, Phenethyl Alcohol, Glyceryl Caprate, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate, Trisodium Ethylenediamine Disuccinate, Hydroxyethoxyphenyl Butanone, Hydroxyethoxyphenyl Butanol, Itaconic Acid, Octopirox, Propanediol Caprylate, Climbazole, Undecylenoyl Glycine, Thymol, 4-Hydroxyacetophenone, Lactic Acid, Sodium Lactate, Trisodium Dicarboxymethyl Alaninate, Frambinon, Xylityl caprylate, Benzoic acid 3-hyroxypropylester, Anisic acid 3-hydroxypropylester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and mixtures of two or more the aforesaid antimicrobial components.

[0093] In a more preferred variant, the antimicrobial compound (a) of the composition of the present invention is selected from the group consisting of Dehydroacetic Acid, Iodopropynyl Butylcarbamate, Salicylic Acid, Chlorphenesin, Isobutylparaben, Sodium Ethylparaben, Diazolidinyl Urea, Diazolidinyl Urea, Farnesol, Bisabolol, Glyceryl Caprylate, Sodium Phytate or Phytic Acid, Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, Chlorhexidine, Glyceryl Laurate, Anisic Acid and its salts, Chlorhexidine Digluconate, TEA-Salicylate, Phenethyl Alcohol, Glyceryl Caprate, Sorbitan Caprylate, Tetrasodium Glutamate Diacetate, Trisodium Ethylenediamine Disuccinate, Sodium Lactate, Frambinon, Xylityl caprylate, Benzoic acid 3-hyroxypropylester, Anisic acid 3-hydroxypropylester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and mixtures of two or more the aforesaid antimicrobial components.

[0094] In a still more preferred variant, the microbial active compound (a) of the composition of the present invention is selected from the group consisting of Phenoxyethanol, Disodium EDTA, Methylparaben, Sodium Benzoate, Benzyl Alcohol, Potassium Sorbate, Benzyl Salicylate, Propylparaben, Methylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Ethylhexylglycerin, Butylparaben, Ethylparaben, Sodium Propylparaben, DMDM Hydantoin, Hydroxyethoxyphenyl Butanone, Hydroxyethoxyphenyl Butanol, Itaconic Acid, Octopirox, Propanediol Caprylate, Climbazole, 4-Hydroxyacetophenone, Frambinon, Xylityl caprylate, Benzoic acid 3-hyroxypropylester, Anisic acid 3-hydroxypropylester, 3-Hydroxypropyl 2-hydroxybenzoate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and mixtures of two or more the aforesaid antimicrobial components.

[0095] In a most preferred variant, the antimicrobial compound (a) of the composition according to the first aspect of the present invention is selected from the group consisting of 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, and mixtures of two or more the aforesaid antimicrobial components.

[0096] Preferably, the food, cosmetic or pharmaceutical preparation or homecare product according to the present invention comprises one or more antimicrobial agents selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2-benzylheptanol, 2-hydroxyacetophenone, 2-methyl 5-cyclohexylpentanol, 3-hydroxypropyl 2-hydroxybenzoate, 4-hydroxyacetophenone, and any mixture thereof. More preferably, the food, cosmetic or pharmaceutical preparation or homecare product according to the present invention comprises one or more antimicrobial agent selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 4-hydroxyacetophenone, and any mixture thereof.

[0097] The aforesaid antimicrobial compound (a) can be used either as a single component or in combination with one or more further antimicrobial components as specified above. In order to enhance the antimicrobial effect and to cover a broader range of antimicrobial effect, a combination of two, three or more antimicrobial components is preferably used.

[0098] The component (b) in the food, cosmetic or pharmaceutical preparation or homecare product according to the first aspect of the present invention is at least one mycosporine-like amino acid compound represented either by the general formula (V)

##STR00005## [0099] as defined herein; [0100] or [0101] represented by the general formula (VI)

##STR00006## [0102] as defined herein.

[0103] Mycosporine-like amino acids (MAAs) are small secondary metabolites produced by organisms that live in environments with high volumes of sunlight, usually marine environments. The MAAs are imine derivatives of mycosporines and contain an amino-cyclohexene-imine ring linked to an amino acid, amino alcohol or amino group. Said compounds are known to demonstrate solar radiation-absorbing characteristics, UV-protection properties. The compounds are capable of electron delocalization. In addition, said compounds demonstrate antioxidant qualities.

[0104] Unless stated otherwise, in the context of the present invention, especially for the definition of the mycosporine-like amino acid compounds represented by any of the general formulae the following general meanings apply:

[0105] The term halogen residue/moiety or group alone or as part of another substituent according to the present invention refers to F, Cl, Br or I.

[0106] The term alkyl alone or as part of another substituent according to the present invention refers to a saturated or mono- or polyunsaturated linear or branched monovalent hydrocarbon radical obtained by removing a hydrogen atom from a single carbon atom of a corresponding parent alkane.

[0107] In a preferred variation, the term alkyl also includes any alkyl moieties in radicals derived therefrom, such as alkoxy, alkylthio, alkylsulphonyl saturated linear or branched hydrocarbon radicals having 1 to 10, 1 to 8, 1 to 6, or 1 to 4 carbon atoms.

[0108] If the alkyl radical is further bonded to another atom, it becomes an alkylene radical or alkylene group. In other words, the term alkylene also refers to a divalent linear or branched alkyl. For example, CH.sub.2CH.sub.3 is an ethyl, while CH.sub.2CH.sub.2 is an ethylene.

[0109] The term alkylene alone or as part of another substituent refers to a saturated linear or branched divalent hydrocarbon radical obtained by removing two hydrogen atoms from a single carbon atom or two different carbon atoms of a starting alkane.

[0110] In preferred variants according to the present invention, the linear or branched alkyl group or alkylene group comprises 1 to 10 carbon atoms. In other still more preferred variants, the linear or branched alkyl group or alkylene group comprises 1 to 6 carbon atoms.

[0111] More preferred according to the invention are saturated linear or branched C1 to C6 alkyl groups or saturated linear or branched C1 to C6 alkylene groups.

[0112] Most preferred the linear or branched alkyl groups or alkylene groups with 1 to 4 carbon atoms.

[0113] Preferred alkyl radicals/moieties or alkyl groups include, but are not limited to: C1 to C6 alkyl comprising methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.

[0114] In a preferred variant, the alkyl radical/moiety is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl or tert-butyl, more preferred from the group consisting of methyl and ethyl.

[0115] The alkyl group or alkylene group as defined above may further be substituted.

[0116] The term alkyl or alkylene further includes radicals or groups having any degree of saturation, i.e., groups having only single carbon-carbon bonds (alkyl or alkylene), groups having one or more double carbon-carbon bonds (alkenyl), radicals having one or more triple carbon-carbon bonds (alkynyl), and groups having a mixture of single, double and/or triple carbon-carbon bonds.

[0117] The term alkenyl alone or as part of another substituent according to the present invention refers to an unsaturated linear or branched monovalent hydrocarbon radical having at least one carbon-carbon double bond (CC double bond). The radical may be in either the cis or trans conformation around the double bond(s). So that the term alkenyl also includes the corresponding cis/trans isomers.

[0118] In preferred variants according to the present invention, the linear or branched alkenyl group comprises 2 to 10 carbon atoms. In other preferred variants, the linear or branched alkenyl group comprises 2 to 6 carbon atoms.

[0119] In still further preferred variants, the linear or branched alkenyl group comprises 2 to 4 carbon atoms.

[0120] Preferred according to the invention are mono- or di-unsaturated linear or branched C1 to C6 alkenyl groups.

[0121] Typical alkenyl radicals or alkenyl groups include, but are not limited to, ethenyl; propenyls such as prop-1-en-1-yl, prop-1-en-2-yl, prop-2-en-1-yl (allyl), prop-2-en-2-yl, cycloprop-1-en-1-yl, cycloprop-2-en-1-yl; butenyls such as but-1-en-1-yl, but-1-en-2-yl, 2-methyl-prop-1-en-1-yl, but-2-en-1-yl, but-2-en-2-yl, buta-1,3-dien-1-yl, buta-1,3-dien-2-yl and the like.

[0122] The alkenyl group as defined above may further be substituted.

[0123] The term alkynyl alone or as part of another substituent according to the present invention refers to an unsaturated linear or branched monovalent hydrocarbon radical having at least one carbon-carbon triple bond (CC triple bond).

[0124] In preferred variants according to the present invention, the linear or branched alkynyl group comprises 2 to 10 carbon atoms. In other preferred variants, the alkynyl group comprises 2 to 6 carbon atoms. In still further preferred variants, the alkynyl group comprises 2 to 4 carbon atoms.

[0125] Most preferred according to the invention are mono- or di-unsaturated linear or branched C1 to C6 alkynyl groups.

[0126] Typical alkynyl radicals/moieties or alkynyl groups include, but are not limited to, ethynyl; propynyls such as prop-1-yn-1-yl, prop-2-in-1-yl, etc.; butynyls such as but-1-in-1-yl, but-1-in-3-yl, but-3-in-1-yl, and the like.

[0127] The alkynyl group as defined above may further be substituted. The alkyl group or alkylene group as defined above may further be substituted.

[0128] The term alkoxy alone or as part of another substituent according to the present invention refers to a linear or branched radical of the formula OR, where R is alkyl or substituted alkyl, as defined herein.

[0129] In preferred variants according to the present invention, the linear or branched alkoxy group comprises 2 to 10 carbon atoms. In other preferred variants, the linear or branched alkoxy group comprises 2 to 6 carbon atoms. In still further preferred variants, the linear or branched alkoxy group comprises 2 to 4 carbon atoms.

[0130] Most preferred according to the invention are linear or branched C1 to C6 alkoxy groups.

[0131] Typical alkoxy radicals/moieties or alkoxy groups include C1 to C6 alkoxy comprising C1 to C4 alkoxy such as. Methoxy, ethoxy, n-propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy or 1,1-dimethylethoxy; as well as pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy or 1-ethyl-2-methylpropoxy.

[0132] In a preferred variant, the alkoxy radical or alkoxy group is selected from the group consisting of methoxy (O-methyl), ethoxy (O-ethyl), propoxy (O-propyl) or butoxy (O-butyl), more preferred from the group consisting of methoxy (O-methyl) or ethoxy (O-ethyl).

[0133] The alkoxy group or alkylene group as defined above may further be substituted.

[0134] The term alkylthio or thioalkoxy alone or as part of another substituent according to the present invention refers to a radical of the formula-SR, wherein R is alkyl or substituted alkyl, as defined herein.

[0135] According to the invention, the term alkyl or alkylene also includes heteroalkyl radicals or heteroalkyl groups. The term heteroalkyl by itself or as part of other substituents refers to alkyl groups in which one or more of the carbon atom(s) is/are independently replaced by the same or another heteroatom or by the same or another heteroatomic group(s). Typical heteroatoms or heteroatomic groups that may replace the carbon atoms include, but are not limited to, O, S, N, Si, NH, S(O), S(O).sub.2, S(O) NH, S(O).sub.2NH, and the like, and combinations thereof. The heteroatoms or heteroatomic groups may be located at any internal position of the alkyl group.

[0136] Typical heteroatomic groups that may be included in these groups include, but are not limited to, O, S, OO, SS, OS, NRR, NN, NN, NNNRR, PR, P(O).sub.2, POR, OP(O).sub.2, SO, SO.sub.2, SR.sub.2OR, and the like, wherein R is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl as defined herein.

[0137] The alkyl group or alkylene group as defined above may further be substituted.

[0138] The term acyl or alkanoyl alone or as part of another substituent according to the present invention refers to a radical RC(O), wherein R is hydrogen, unsubstituted or substituted alkyl, unsubstituted substituted cycloalkyl, unsubstituted or substituted aryl, arylalkyl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted heteroarylalkyl, as defined herein.

[0139] Representative examples include, but are not limited to, formyl, acetyl, propionyl, butyryl, valeryl, benzoyl, cyclohexylcarbonyl, cyclohexylmethylcarbonyl, benzylcarbonyl, and the like.

[0140] The term cycloalkyl alone or as part of another substituent according to the present invention refers to a saturated or mono- or polyunsaturated, non-aromatic, cyclic monovalent hydrocarbon radical in which the carbon atoms are ring-linked and which has no heteroatom.

[0141] The carbon ring can occur as a monocyclic compound, which has only a single ring, or as a polycyclic compound, which has two or more rings.

[0142] In one preferred variation, the term cycloalkyl includes a three- to ten-membered monocyclic cycloalkyl radical or cycloalkyl group or a nine- to twelve-membered polycyclic cycloalkyl radical or cycloalkyl group. In other still more preferred variants, the cycloalkyl moiety comprises a five-, six- or seven-membered monocyclic cycloalkyl moiety or a nine- to twelve-membered bicyclic cycloalkyl moiety.

[0143] In a preferred embodiment according to the present invention, a cycloalkyl radical or group comprises 3 to 20 carbon atoms. In an even more preferred embodiment, a cycloalkyl radical comprises 6 to 15 carbon atoms. In a most preferred embodiment, a cycloalkyl radical comprises 6 to 10 carbon atoms. Most preferred are monocyclic C3 to C7 cycloalkyl groups.

[0144] Typical cycloalkyl radicals or cycloalkyl groups include, but are not limited to, saturated carbocyclic radicals having 3 to 20 carbon atoms, such as C3 to C12 carbocyclyl, comprising cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, cycloundecyl, and cyclododecyl; cyclopentyl, cyclohexyl, cycloheptyl, as well as cyclopropyl-methyl, cyclopropyl-ethyl, cyclobutyl-methyl, cyclobutyl-ethyl, cyclopentyl-methyl, cyclopentyl-ethyl, cyclohexyl-methyl, or C3- to C7-carbocyclyl comprising cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopropyl-methyl, cyclopropyl-ethyl, cyclobutyl-methyl, cyclopentyl-ethyl, cyclohexyl-methyl, cyclobut-1-en-1-yl, cyclobut-1-en-3-yl, 3-dien-1-yl and the like.

[0145] Polycyclic cycloalkyl radicals or cycloalkyl groups preferred according to the invention include but are not limited to naphthyl, indenyl, groups and the like.

[0146] According to the invention, the term cycloalkyl also includes cycloalkenyls, i.e. unsaturated cyclic hydrocarbon radicals containing CC double bonds between two carbon atoms of the ring molecule. In a broader sense, cycloalkenyls are compounds with one, two or more double bond(s), where the number of possible, mostly conjugated double bonds in the molecule depends on the ring size.

[0147] Typical cycloalkenyls include, but are not limited to, cyclopropenyl, cyclopentenyl, cyclohexenyl, cyclopentadienyl, and the like.

[0148] According to the invention, the term cycloalkyl further includes cycloalkynyls, i.e. unsaturated, CC-triple bonds, containing cyclic hydrocarbon radicals between two carbon atoms of the ring molecule, the triple bond depending on the ring size for reasons of ring tension.

[0149] Typical cycloalkynyles include cyclooctin.

[0150] The cycloalkyl, cycloalkenyl or cycloalkynyl moieties or groups, as defined above, may further be substituted.

[0151] The term aryl alone or as part of another substituent according to the present invention refers to a monovalent aromatic hydrocarbon radical derived by removing a hydrogen atom from a single carbon atom of an aromatic ring SY-stem.

[0152] In one preferred variation, the term aryl includes a three- to ten-membered monocyclic aryl radical or aryl group or a nine- to twelve-membered polycyclic aryl radical or aryl group. In other still more preferred variants, the carboaryl radical comprises a five-, six- or seven-membered monocyclic carboaryl radical or a nine- to twelve-membered bicyclic carboaryl radical.

[0153] In a preferred embodiment according to the present invention, the aryl radical comprises 3 to 20 carbon atoms. In a preferred variation, the aryl moiety comprises 6 to 15 ring atoms. In an even more preferred embodiment, an aryl radical comprises 6 to 10 carbon atoms.

[0154] Most preferred according to the invention are monocyclic C3 to C10 aryl groups. Most preferred are monocyclic C3 to C7 aryl groups.

[0155] Typical aryl radicals include, without being limited thereto, benzene, phenyl, biphenyl, naphthyl such as 1- or 2-naphthyl, tetrahydronaphthyl, fluorenyl, indenyl, and phenanthrenyl. Typical carboaryl moieties further include, but are not limited to, groups derived from aceanthrylene, acenaphthylene, acephenanthrylene, anthracene, azulene, benzene, chrysene, corone, fluoranthene, fluorene, hexacene, hexaphene, hexalene, as-indacene, S-indacene, indane, indene, naphthalene, octacene, octaphene, octalene, ovalene, penta-2,4-diene, pentacene, pentalene, pentaphene, perylene, phenalene, phenanthrene, picene, pleiadene, pyrene, pyranthrene, rubicene, triphenylene, trinaphthalene and the like.

[0156] Aromatic polycyclic aryl radicals or aryl groups preferred according to the invention include, but are not limited to, naphthalene, biphenyl and the like.

[0157] The aryl moiety or group, as defined above, may further be substituted.

[0158] The term arylalkyl alone or as part of another substituent according to the present invention refers to an acyclic alkyl group in which one of the hydrogen atoms attached to a carbon atom, typically a terminal or sp carbon atom, is replaced by an aryl group as defined herein. In other words, arylalkyl may also be considered as alkyl substituted by aryl. Typical arylalkyl groups include, but are not limited to, benzyl, 2-phenylethan-1-yl, 2-phenylethen-1-yl, naphthylmethyl, 2-naphthylethan-1-yl, 2-naphthylethen-1-yl, naphthobenzyl, 2-naphthophenylethan-1-yl, and the like.

[0159] The term heteroarylalkyl alone or as part of another substituent refers to a cyclic alkyl group in which one of the hydrogen atoms attached to a carbon atom is replaced by a heteroaryl group.

[0160] In a preferred embodiment according to the present invention, the heteroarylalkyl group is a 6- to 20-membered heteroarylalkyl, e.g., the alkyl, alkenyl, or alkynyl group of the heteroarylalkyl is a C1- to C6-alkyl and the heteroaryl group is a 5- to 15-membered heteroaryl group. In other embodiments, the heteroarylalkyl is a 6- to 13-membered heteroarylalkyl, e.g., the alkyl, alkenyl, or alkynyl group is a C1- to C3-alkyl and the heteroaryl group is a 5 to 10-membered heteroaryl.

[0161] The term heterocycloalkyl alone or as part of another substituent according to the present invention refers to a saturated or mono- or polyunsaturated, non-aromatic, cyclic monovalent hydrocarbon radical in which one or more carbon atom(s) is/are independently replaced by the same or a different heteroatom. Typical heteroatoms to replace the carbon atom(s) include, but are not limited to, N, P, O, S, Si, etc. Typical heterocycloalkyl groups include, without being limited thereto, groups derived from epoxides, azirines, thiiranes, imidazolidine, morpholine, piperazine, piperidine, pyrazolidine, pyrrolidone, quinuclidine and the like.

[0162] In a preferred embodiment according to the present invention, the heterocycloalkyl moiety or group comprises 3 to 20 ring atoms. In a preferred variation, the heterocycloalkyl moiety comprises 6 to 15 ring atoms. In an even more preferred embodiment, the heterocycloalkyl moiety comprises 6 to 10 carbon atoms.

[0163] The heterocycloalkyl moiety can occur as a monocyclic compound, which has only a single ring, or as a polycyclic compound, which has two or more rings, such as bicyclic, tricyclic or spirocyclic.

[0164] Preferably, the term heterocycloalkyl includes three- to seven-membered, saturated or mono- or polyunsaturated heterocycloalkyl moieties comprising one, two, three or four heteroatoms selected from the group consisting of O, N and S. The heteroatom or heteroatoms may occupy any position in the heterocycloalkyl ring.

[0165] In one preferred variation, the term heterocycloalkyl includes a three- to ten-membered monocyclic heterocycloalkyl radical or a nine- to twelve-membered polycyclic heterocycloalkyl radical. In other still more preferred variants, the heterocycloalkyl moiety comprises a five-, six- or seven-membered monocyclic heterocycloalkyl moiety or a nine- to twelve-membered bicyclic heterocycloalkyl moiety.

[0166] Most preferred according to the invention are monocyclic heterocycloalkyl radicals comprising 3 to 12 carbon atoms. Most preferred are monocyclic heterocycloalkyl radicals having 5 to 7 ring atoms.

[0167] Typical heterocycloalkyl moieties include, but are not limited to: Five- or six-membered, saturated or monounsaturated heterocycloalkyl containing one or two nitrogen atoms and/or one oxygen or sulphur atom or one or two oxygen and/or sulphur atoms as ring members comprising 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetrahydrothienyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-Isoxazolidinyl, 4-Isoxazolidinyl, 5-Isoxazolidinyl, 3-Isothiazolidinyl, 4-Isothiazolidinyl, 5-Isothiazolidinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 2-Imidazolidinyl, 4-Imidazolidinyl, 2-pyrrolin-2-yl, 2-pyrrolin-3-yl, 3-pyrrolin-2-yl, 3-pyrrolin-3-yl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1,3-dioxan-5-yl, 2-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothienyl, 3-hexahydropyridazinyl, 4-hexahydropyridazinyl, 2-hexahydropyrimidinyl, 4-hexahydropyrimidinyl, 5-hexahydropyrimidinyl, 2-piperazinyl and the like.

[0168] The heterocycloalkyl moiety or group, as defined above, may further be substituted.

[0169] The term heteroaryl by itself or as part of another substituent according to the present invention refers to a monovalent heteroaromatic radical obtained by removing a hydrogen atom from a single atom of a heteroaromatic ring SY-stem. Typical heteroaryl radicals, or. Heteroaryl groups include, but are not limited to, those derived from acridine, -carboline, chroman, chromium, cinnoline, furan, imidazole, indazole, indole, indoline, indolizine, isobenzofuran, isochromium, isoindole, isoindoline, isoquinoline, isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole, perimidine, phenanthridine, phenanthroline, phenazine, phthalazine, pteridine, purine, pyran, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, thiazole, thiophene, triazole, xanthene and the like are derived.

[0170] The heteroaryl moiety can occur as a monocyclic compound having only a single ring or as a polycyclic compound having two or more rings.

[0171] In one preferred variation, the term heteroaryl includes a three- to ten-membered monocyclic heteroaryl radical or a nine- to twelve-membered polycyclic heteroaryl radical. In other still more preferred variants, the heteroaryl moiety comprises a five-, six- or seven-membered monocyclic heteroaryl moiety or a nine- to twelve-membered bicyclic heteroaryl moiety.

[0172] Preferably, the term heteroaryl includes three- to seven-membered monocyclic heteroaryl radicals comprising one, two, three or four heteroatoms selected from the group consisting of O, N and S. The heteroatom or heteroatoms may occupy any position in the heteroaryl ring.

[0173] In a preferred embodiment according to the present invention, the heteroaryl moiety or group comprises 3 to 20 ring atoms. In an even more preferred variant, the heteroaryl moiety comprises 6 to 15 ring atoms. In a most preferred embodiment, the heteroaryl group comprises 6 to 10 ring atoms. Most preferred according to the invention are monocyclic C3 to C7 heteroaryl groups.

[0174] Particularly preferred heteroaryl moieties or heteroaryl groups include, but are not limited to, those derived from furan, thiophene, pyrrole, benzothiophene, benzofuran, benzimidazole, indole, pyridine, pyrazole, quinoline, imidazole, oxazole, isoxazole, and pyrazine.

[0175] Five-membered aromatic heteroaryl radicals containing, in addition to carbon atoms, one, two or three nitrogen atoms or one or two nitrogen atoms and one sulfur or oxygen atom as ring atoms include 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 3-pyrrolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-Imidazolyl, 4-Imidazolyl, and 1,3,4-triazol-2-yl.

[0176] Five-membered aromatic heteroaryl radicals containing one, two, three or four nitrogen atoms as ring atoms include 1-, 2- or 3-pyrrolyl, 1-, 3- or 4-pyrazolyl, 1-, 2- or 4-Imidazolyl, 1,2,3-[1H]-triazol-1-yl, 1,2,3-[2H]-triazol-2-yl, 1,2,3-[1H]-triazol-4-yl, 1,2,3-[1H]-triazol-5-yl, 1,2,3-[2H]-triazol-4-yl, 1,2,4-[1H]-triazol-1-yl, 1,2,4-[1H]-triazol-3-yl, 1,2,4-[1H]-triazol-5-yl, 1,2,4-[4H]-triazol-4-yl, 1,2,4-[4H]-triazol-3-yl, [1H]-tetrazol-1-yl, [1H]-tetrazol-5-yl, [2H]-tetrazol-2-yl, [2H]-tetrazol-5-yl and the like.

[0177] Five-membered aromatic heteroaryl radicals containing a heteroatom selected from oxygen or sulphur and optionally one, two or three nitrogen atoms as ring atoms include 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 3- or 4-Isoxazolyl, 3- or 4-isothiazolyl, 2-, 4- or 5-oxazolyl, 2-, 4- or 5-thiazolyl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-2-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl and 1,3,4-oxadiazol-2-yl.

[0178] Six-membered heteroaryl radicals containing, in addition to carbon atoms, one or two or one, two or three nitrogen atoms as ring atoms, and comprising, for example. 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl, 1,2,4-triazin-3-yl; 1,2,4-triazin-5-yl, 1,2,4-triazin-6-yl and 1,3,5-triazin-2-yl.

[0179] The heteroaryl moiety or group, as defined above, may further be substituted.

[0180] The term C-spirocycles in the context of the present application means compounds that have at least two molecular rings with only one common atom. The simplest spiro compounds are bicyclic (having just two rings) or have a bicyclic portion as part of the larger ring system, in either case with the two rings connected through the defining single common atom. The one common atom connecting the participating rings distinguishes spiro compounds from other bicyclic structures: from isolated ring compounds like biphenyl that have no connecting atoms, from fused ring compounds like decalin having two rings linked by two adjacent atoms, and from bridged ring compounds like norbornane with two rings linked by two non-adjacent atoms. Spiro compounds may be fully carbocyclic (all carbon) or heterocyclic (having one or more non-carbon atom, such as N, O and S). The common atom that connects the two (or sometimes three) rings is called the spiro atom. Preferably, the spiro atom is a carbon atom. More preferably, the C-spirocycles compound means compounds that are fully carbocyclic (all carbon).

[0181] The term substituted in the context of the present invention means that one or more hydrogen atoms of the indicated radical or group is/are independently replaced by the same or a different substituent(s). Additionally, the term substituted specifically provides for one or more, i.e., two, three, or even more, substitutions commonly used in the art. However, it is generally known that the substituents should be selected so that they do not adversely affect the useful properties of the compound or its function.

[0182] Suitable substituents in the context of the present invention preferably include halogen, perfluoroalkyl groups, perfluoroalkoxy groups, alkyl groups, alkenyl groups, alkynyl groups, hydroxy groups, oxo groups, mercapto groups, alkylthio groups, alkoxy groups, aryl or heteroaryl groups, aryloxy group or heteroaryloxy groups, arylalkyl or heteroarylalkyl groups, arylalkoxy or heteroarylalkoxy groups, amino groups, alkyl and dialkylamino groups, carbamoyl groups, alkylcarbonyl groups, carboxyl groups, alkoxycarbonyl groups, alkylaminocarbonyl groups, dialkylaminocarbonyl groups, arylcarbonyl groups, aryloxycarbonyl groups, alkylsulfonyl groups, arylsulfonyl groups, cycloalkyl groups, cyano groups, C1 to C6 alkylthio groups, arylthiol group, nitro group, keto group, acyl group, boronate or boronyl group, phosphate or phosphonyl group, sulfamyl group, sulfonyl group, sulfinyl group, and combinations thereof.

[0183] Substituents or substituent groups useful for substituting saturated carbon atoms in the indicated group or radical more preferably include, but are not limited to, halogen, hydroxyl, alkyl, alkenyl, alkynyl, alkoxyl, NH.sub.2, amino (primary, secondary, or tertiary), nitro, thiol, thioether, imine, cyano, amido, phosphonato, phosphine, carboxyl, thiocarbonyl, sulfonyl, sulfonamide, ketone, aldehyde, ester, acetyl, acetoxy, carbamoyl, oxygen (O); haloalkyl (e.g., trifluoromethyl); aminoacyl and aminoalkyl, carbocyclic cycloalkyl, which may be monocyclic or fused or non-fused polycyclic (e.g., cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl), or a heterocycloalkyl, which may be monocyclic or fused or non-fused polycyclic (e.g. pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, or thiazinyl), carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic aryl (e.g., phenyl, naphthyl, pyrrolyl, indolyl, furanyl, thiophenyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyrazolyl, pyridinyl, quinolinyl, isoquinolinyl, acridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, benzimidazolyl, benzothiophenyl, or benzofuranyl), CO.sub.2CH.sub.3, CONH.sub.2, OCH.sub.2CONH.sub.2; SO.sub.2NH.sub.2, OCHF.sub.2, CF.sub.3, OCF.sub.3.

[0184] According to the invention, the substituents used to replace a particular radical or radical may in turn be further substituted, typically with one or more of the same or different radicals selected from the various groups indicated above and as defined in detail above. In the case of substituted combinations such as substituted arylalkyl, either the aryl or the alkyl group may be substituted, or both the aryl and the alkyl group may be substituted with one or more substituents.

[0185] In a preferred variant, Z in the general formula (V) is either OR2 or amide.

[0186] In a further preferred variant, R1 in the general formula (V) is CH.sub.2.

[0187] In a further preferred variant, R1 in the general formula (V) is C(alkyl).sub.2.

[0188] In a further preferred variant, R1 in the general formula (V) is O.

[0189] In a further preferred variant, R1 in the general formula (V) is S.

[0190] In a further preferred variant, R1 in the general formula (V) is SO.

[0191] In a further preferred variant, R1 in the general formula (V) is SO.sub.2.

[0192] In a further preferred variant, R1 in the general formula (V) is NH.

[0193] In a still further preferred variant, R1 in the general formula (V) is N(alkyl).

[0194] Most preferred the R1 in the general formula (V) is either CH.sub.2 or C(alkyl).sub.2.

[0195] In a preferred variant, R2 in the general formula (V) is H.

[0196] In a further preferred variant, R2 in the general formula (V) is methyl.

[0197] In a further preferred variant, R2 in the general formula (V) is ethyl.

[0198] In a further preferred variant, R2 in the general formula (V) is propyl.

[0199] In a further preferred variant, R2 in the general formula (V) is isopropyl.

[0200] In a further preferred variant, R2 in the general formula (V) is butyl.

[0201] In a further preferred variant, R2 in the general formula (V) is isobutyl.

[0202] In a further preferred variant, R2 in the general formula (V) is tert-butyl.

[0203] In a further preferred variant, R2 in the general formula (V) is

##STR00007##

[0204] In a further preferred variant, R2 in the general formula (V) is

##STR00008##

[0205] In a preferred variant, R2 in the general formula (V) is

##STR00009##

(2-ethyl-hexyl).

[0206] In a still further preferred variant, R2 in the general formula (V) is phenyl.

[0207] Most preferred the R2 in the general formula (V) is either H or ethyl or isopropyl or 2-ethylhexyl or phenyl.

[0208] In a preferred variant, amide in the general formula (V) is NH.sub.2.

[0209] In a further preferred variant, amide in the general formula (V) is NH(alkyl), wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0210] In a further preferred variant, amide in the general formula (V) is N(alkyl).sub.2, wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0211] In a further preferred variant, amide in the general formula (V) is N(O-alkyl)(alkyl) (Weinreb amide), wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0212] In a still further preferred variant, amide in the general formula (V) is N(OH)(H) (hydroxamate).

[0213] Most preferred the amide in the general formula (V) is NH.sub.2, N(methyl).sub.2 or N(ethyl).sub.2 or N(O-alkyl)(alkyl) (Weinreb amide), wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl, orN(OH)(H) (hydroxamate).

[0214] In a preferred variant, R3 in the general formula (V) is H.

[0215] In a further preferred variant, R3 in the general formula (V) is methyl.

[0216] In a further preferred variant, R3 in the general formula (V) is ethyl.

[0217] In a further preferred variant, R3 in the general formula (V) is O-methyl.

[0218] In a further preferred variant, R3 in the general formula (V) is C(O)OH.

[0219] In a further preferred variant, R3 in the general formula (V) is C(O)CH.sub.3.

[0220] In a further preferred variant, R3 in the general formula (V) is C(O)C.sub.3H.sub.7.

[0221] In a still further preferred variant, R3 in the general formula (V) is C(O)O-methyl.

[0222] Most preferred the R3 in the general formula (V) is either H or methyl or O-methyl.

[0223] In a preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (V) is either an acid compound or an ester compound represented by the general formula (VII)

##STR00010##

wherein R1, R2, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0224] In a preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (V) is an acid compound represented by the general formula (VII-acid)

##STR00011##

wherein R1, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0225] The mycosporine-like amino acid compounds according to general formula (VII-acid) are particularly photo-stable and temperature-stable compounds and show stability in pH solution or in different emulsion types and do not degrade.

[0226] Especially, the mycosporine-like amino acid compounds as defined herein have a better pH stability in a broader pH-range compared to their respective ester compounds which hydrolize, and, thus, are not stable in alkaline solutions having a pH higher than 9.

[0227] In addition, said mycosporine-like amino acid compounds have also a better solubility in water compared to their corresponding ester compounds. Due to their better solubility in water, said mycosporine-like amino acid compounds can be incorporated into the water-phase of formulations in higher concentrations, resulting in a better antimicrobial enhancing or boosting effect in food, cosmetic or pharmaceutical preparations or homecare products. The improved solubility in water is particular useful, since usually microbial contamination takes place in the water phase. This is in particular beneficial for the development of the antimicrobial effect of the mycosporine-like amino acid compounds in the water phase.

[0228] In a preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (V) is an ester compound represented by the general formula (VII-ester)

##STR00012##

wherein R1, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0229] Preferably, the alkyl residue in the general formula (VII-ester) is methyl or ethyl or propyl or isopropyl or butyl or isobutyl, or tert-butyl. Most preferred the alkyl residue in the general formula (VII-ester) is methyl. Such ester compounds are particularly stable.

[0230] In an alternative preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (V) is an amide compound represented by the general formula (VIII)

##STR00013##

wherein R1, amide, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0231] In a more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (V) is an amide compound represented by the general formula (VIII-amide)

##STR00014##

wherein R1, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V) and R11 and R12 are independently from each other selected from the group consisting of H, OH and alkyl.

[0232] In a preferred variant according to the first aspect of the present invention, in the general formula (VIII-amide), R11 and/or R12 are H.

[0233] In a further preferred variant, the R11 alkyl and R12 alkyl in the general formula (VIII-amide) are independently from each other selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0234] Preferably, R11 and/or R12 in the general formula (VIII-amide) are each H or each methyl.

[0235] In a still more preferred variant, the mycosporine-like amino acid compound (b) of the general formula (V) is a Weinreb amide compound represented by the general formula (VIII-Weinreb amide)

##STR00015##

wherein R1, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0236] In a preferred variant, the alkyl residue in the general formula (VIII-Weinreb amide) is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl, more preferred the alkyl residue is methyl.

[0237] Alternatively, in a still more preferred variant, the mycosporine-like amino acid compound (b) of the general formula (V) is a hydroxamate compound represented by the general formula (VIII-hydroxamate derivative)

##STR00016##

wherein R1, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0238] Alternatively, in a still further preferred variant, the mycosporine-like amino acid compound (b) of the general formula (V) is an alkylated hydroxamate compound represented by the general formula (VIII-alkylated hydroxamate derivative)

##STR00017##

wherein R1, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0239] In a preferred variant, the alkyl residue in the general formula (VIII-alkylated hydroxamate derivative) is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl, more preferred the alkyl is methyl.

[0240] In a preferred alternatively variant the mycosporine-like amino acid compound (b) is represented by the general formula (A)

##STR00018##

wherein R1, R3, R4, R5 and R6 have the same meaning as defined herein for the general formula (V).

[0241] Within the present invention, the same preferred variants as defined herein for the mycosporine-like amino acid compounds according to the general formula (V) apply analogously for the mycosporine-like amino acid compounds according to the general formulae (VII) or (VIII) and their variants or general formula (A).

[0242] In a further preferred variant, R1 in the general formula (VI) is CH.sub.2.

[0243] In a further preferred variant, R1 in the general formula (VI) is C(alkyl).sub.2.

[0244] In a further preferred variant, R1 in the general formula (VI) is O.

[0245] In a further preferred variant, R1 in the general formula (VI) is S.

[0246] In a further preferred variant, R1 in the general formula (VI) is SO.

[0247] In a further preferred variant, R1 in the general formula (VI) is SO.sub.2.

[0248] In a further preferred variant, R1 in the general formula (VI) is NH.

[0249] In a still further preferred variant, R1 in the general formula (VI) is N(alkyl).

[0250] Most preferred the R1 in the general formula (VI) is either CH.sub.2 or C(alkyl).sub.2.

[0251] In a preferred variant, R2 in the general formula (VI) is-CH.sub.2OH.

[0252] In a further preferred variant, R2 in the general formula (VI) is C(O)OY.

[0253] In a further preferred variant, R2 in the general formula (VI) is C(O)-amide.

[0254] Most preferred the R2 in the general formula (VI) is C(O)OY or C(O)-amide.

[0255] In a further preferred variant, X in the general formula (VI) is CH.sub.2.

[0256] In a further preferred variant, X in the general formula (VI) is CO.

[0257] In a further preferred variant, X in the general formula (VI) is O.

[0258] In a further preferred variant, X in the general formula (VI) is S.

[0259] In a further preferred variant, X in the general formula (VI) is SO.

[0260] In a further preferred variant, X in the general formula (VI) is SO.sub.2.

[0261] In a further preferred variant, X in the general formula (VI) is NH.

[0262] In a still further preferred variant, X in the general formula (VI) is N(alkyl), wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0263] Most preferred the X in the general formula (VI) is either S, SO or SO.sub.2.

[0264] In a preferred variant, Y in the general formula (VI) is H.

[0265] In a further preferred variant, Y in the general formula (VI) is methyl.

[0266] In a further preferred variant, Y in the general formula (VI) is ethyl.

[0267] In a further preferred variant, Y in the general formula (VI) is propyl.

[0268] In a further preferred variant, Y in the general formula (VI) is isopropyl.

[0269] In a further preferred variant, Y in the general formula (VI) is butyl.

[0270] In a further preferred variant, Y in the general formula (VI) is isobutyl.

[0271] In a further preferred variant, Y in the general formula (VI) is tert-butyl.

[0272] In a further preferred variant, Y in the general formula (VI) is

##STR00019##

[0273] In a further preferred variant, Y in the general formula (VI) is

##STR00020##

[0274] In a preferred variant, Y in the general formula (VI) is

##STR00021##

(2-ethyl-hexyl).

[0275] In a still further preferred variant, Y in the general formula (VI) is phenyl.

[0276] Most preferred the Y in the general formula (VI) is H or ethyl or isopropyl or 2-ethylhexyl or phenyl.

[0277] In a preferred variant, amide in the general formula (VI) is NH.sub.2.

[0278] In a further preferred variant, amide in the general formula (VI) is NH(alkyl), wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0279] In a further preferred variant, amide in the general formula (VI) is N(alkyl).sub.2, wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0280] In a further preferred variant, amide in the general formula (VI) is N(O-alkyl)(alkyl) (Weinreb amide), wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0281] In a still further preferred variant, amide in the general formula (V) is-N(OH)(H) (hydroxamate).

[0282] Most preferred the amide in the general formula (V) is NH.sub.2, N(methyl).sub.2 or N(ethyl) 2 orN(O-alkyl)(alkyl) (Weinreb amide), wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl, orN(OH)(H) (hydroxamate).

[0283] In a more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) is an alcohol compound represented by the general formula (IX-alcohol)

##STR00022##

wherein R1, X, R4, R5 and R6 have the same meaning as defined herein for the general formula (VI).

[0284] Alternatively, in a more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (VI) is an acid compound represented by the general formula (IX-acid)

##STR00023##

wherein R1, X, R4, R5 and R6 have the same meaning as defined herein for the general formula (VI).

[0285] Alternatively, in a more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (VI) is an ester compound represented by the general formula (VII-ester)

##STR00024##

wherein R1, X, R4, R5 and R6 have the same meaning as defined herein for the general formula (VI).

[0286] Preferably, the alkyl residue in the general formula (VII-ester) is methyl or ethyl or propyl or isopropyl or butyl or isobutyl or tert-butyl, more preferred the alkyl residue is methyl.

[0287] In an alternative more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (VI) is an amide compound represented by the general formula (X)

##STR00025##

wherein R1, amide, X, R4, R5 and R6 have the same meaning as defined herein for the general formula (VI).

[0288] In a more preferred alternatively variant according to the first aspect of the present invention, the mycosporine-like amino acid compound (b) of the general formula (VI) is an amide compound represented by the general formula (X-amide),

##STR00026##

wherein R1, X, R4, R5 and R6 have the same meaning as defined herein for general formula (VI) and R11 and R12 are independently from each other selected from the group consisting of H, OH and alkyl.

[0289] In a preferred variant according to the first aspect of the present invention, in the general formula (X-amide), R11 and/or R12 are H.

[0290] Preferably, the R11 alkyl and R12 alkyl in the general formula (X-amide) is methyl or ethyl or propyl or isopropyl or butyl or isobutyl or tert-butyl.

[0291] Preferably, R11 and/or R12 in the general formula (X-amide) are each H or each methyl.

[0292] In a still more preferred variant, the mycosporine-like amino acid compound (b) of the general formula (VI) is a Weinreb amide compound represented by the general formula (X-Weinreb amide)

##STR00027##

wherein R1, X, R4, R5 and R6 have the same meaning as defined herein for the general formula (VI).

[0293] In a preferred variant, the alkyl residue in the general formula (X-Weinreb amide) is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl, more preferred the alkyl residue is methyl.

[0294] Alternatively, in a still more preferred variant, the mycosporine-like amino acid compound (b) of the general formula (VI) is a hydroxamate compound represented by the general formula (X-hydroxamate derivative)

##STR00028##

wherein R1, X, R4, R5 and R6 have the same meaning as defined herein for the general formula (VI).

[0295] Alternatively, in a still further preferred variant, the mycosporine-like amino acid compound (b) of the general formula (VI) is an alkylated hydroxamate compound represented by the general formula (VIII-alkylated hydroxamate derivative)

##STR00029##

wherein R1, X, R4, R5 and R6 have the same meaning as defined herein for the general formula (VI).

[0296] In a preferred variant, the alkyl residue in the general formula (X-alkylated hydroxamate derivative) is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl, more preferred the alkyl residue is methyl.

[0297] Within the present invention, the same preferred variants as defined herein for the mycosporine-like amino acid compounds according to general formula (VI) apply analogously for the mycosporine-like amino acid compounds according to the general formulae (IX) or (X) and their variants.

[0298] In the following, the term according to the general formulae YZ and their variants includes any sub-formulal of said general formulae as disclosed herein. Accordingly, variants of the general formulae (V) and (VI) as defined herein, include formula (VII), formula (VIII), formula (IX) and formula (X) as defined herein. Variants of the general formulae (VII) and (VIII) as defined herein, include sub-formula (VII-acid), sub-formula (VII-ester), sub-formula (VIII-amide), sub-formula (VIII-Weinreb amide), sub-formula (VIII-hydroxamate derivative) and sub-formula (VIII-alkylated hydroxamate derivative) as defined herein. Variants of the general formulae (IX) and (X) as defined herein, include formula (IX-acid), formula (IX-ester), formula (X-amide), formula (X-Weinreb amide), formula (X-hydroxamate derivative) and formula (X-alkylated hydroxamate derivative) as defined herein.

[0299] In a further preferred variant, in the general formulae (VI), (IX), (X) and their variants, X is selected from the group consisting of selected from the group consisting of CH.sub.2, unsubstituted or substituted CH(alkyl), unsubstituted or substituted C(alkyl).sub.2, unsubstituted or substituted CH(alkenyl), unsubstituted or substituted CH(alkynyl), unsubstituted or substituted CH(alkoxy), unsubstituted or substituted CH(alkylthio), unsubstituted or substituted CH(cycloalkyl), unsubstituted or substituted CH(aryl), unsubstituted or substituted CH(heterocycloalkyl), unsubstituted or substituted CH(heteroaryl), CR7R8, CO, S, SO, SO.sub.2, NH, unsubstituted or substituted N(alkyl), unsubstituted or substituted N(alkenyl), unsubstituted or substituted N(alkynyl), unsubstituted or substituted N(alkoxy), unsubstituted or substituted N(alkylthio), unsubstituted or substituted N(cycloalkyl), unsubstituted or substituted N(aryl), unsubstituted or substituted N(heterocycloalkyl), unsubstituted or substituted N(heteroaryl), and unsubstituted or substituted C-spirocycles.

[0300] In a further preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (V), wherein [0301] Z is OR2 or amide; and/or [0302] R1 is selected from the group consisting of CH.sub.2, C(alkyl).sub.2, O, S, SO, SO.sub.2, NH and N(alkyl); and/or [0303] R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00030## (2-ethyl-hexyl) and phenyl; or [0304] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or [0305] R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or [0306] the substituents R4, R5 and R6 have the same meaning as defined for formula (V); [0307] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0308] In another preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (VII) or (VIII), wherein [0309] R1 is selected from the group consisting of CH.sub.2, C(alkyl).sub.2, O, S, SO, SO.sub.2, NH and N(alkyl); and/or [0310] R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00031## (2-ethyl-hexyl) and phenyl; or [0311] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or [0312] R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or [0313] the substituents R4, R5 and R6 have the same meaning as defined for formula (V); [0314] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0315] In another preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formula (VI), wherein [0316] R1 is selected from the group consisting of CH.sub.2, C(alkyl).sub.2, O, S, SO, SO.sub.2, NH and N(alkyl); and/or [0317] R2 is selected from the group consisting of CH.sub.2OH, C(O)OY, and C(O)-amide; and/or [0318] X is selected from the group consisting of CH.sub.2, CO, O, S, SO, SO.sub.2, NH, and N(alkyl); and/or [0319] Y is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00032## (2-ethyl-hexyl) and phenyl; and/or [0320] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or [0321] the substituents R4, R5 and R6 have the same meaning as defined for formula (VI); [0322] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0323] In a further preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (V), wherein [0324] Z is OR2 or amide; and/or [0325] R1 is selected from the group consisting of CH.sub.2 and C(methyl).sub.2; and/or [0326] R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00033## (2-ethyl-hexyl) and phenyl; or [0327] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or [0328] R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or [0329] the substituents R4, R5 and R6 have the same meaning as defined for formula (V); [0330] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0331] In another preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (VII) or (VIII), wherein [0332] R1 is selected from the group consisting of CH.sub.2 and C(methyl).sub.2; and/or [0333] R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00034## [0334] (2-ethyl-hexyl) and phenyl; or [0335] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or [0336] R3 is selected from the group consisting of H, methyl, ethyl, O-methyl, C(O)OH, C(O)CH.sub.3, C(O)C.sub.3H.sub.7 and C(O)O-methyl; and/or [0337] the substituents R4, R5 and R6 have the same meaning as defined for formula (V); [0338] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0339] In another preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formula (VI), wherein [0340] R1 is selected from the group consisting of CH.sub.2 and C(methyl).sub.2; and/or [0341] R2 is selected from the group consisting of CH.sub.2OH, C(O)OY, and C(O)-amide; and/or [0342] X is selected from the group consisting of CH.sub.2, CO, O, S, SO, SO.sub.2, NH, and N(alkyl); and/or [0343] Y is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00035## (2-ethyl-hexyl) and phenyl; and/or [0344] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and/or [0345] the substituents R4, R5 and R6 have the same meaning as defined for formula (VI); [0346] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0347] In a still more preferred variant according to the present invention, the food, cosmetic or pharmaceutical preparation or homecare product comprises at least one mycosporine-like amino acid compound selected from the group consisting of the following compounds I-1 to I-128 according to the general formula (V) and II-1 to II-192 according to the general formula (V):

TABLE-US-00001 TABLE 1 [00036] R1 R3 Z I-1 CH2 H OR2 I-2 CH2 methyl OR2 I-3 CH2 ethyl OR2 I-4 CH2 Omethyl OR2 I-5 CH2 C(O)OH OR2 I-6 CH2 C(O)CH3 OR2 I-7 CH2 C(O)C3H7 OR2 I-8 CH2 C(O)Omethyl OR2 I-9 CH2 H amide I-10 CH2 methyl amide I-11 CH2 ethyl amide I-12 CH2 O-methyl amide I-13 CH2 C(O)OH amide I-14 CH2 C(O)CH3 amide I-15 CH2 C(O)C3H7 amide I-16 CH2 C(O)O-methyl amide I-17 C(methyl)2 H OR2 I-18 C(methyl)2 methyl OR2 I-19 C(methyl)2 ethyl OR2 I-20 C(methyl)2 O-methyl OR2 I-21 C(methyl)2 C(O)OH OR2 I-22 C(methyl)2 C(O)CH3 OR2 I-23 C(methyl)2 C(O)C3H7 OR2 I-24 C(methyl)2 C(O)O-methyl OR2 I-25 C(methyl)2 H amide I-26 C(methyl)2 methyl amide I-27 C(methyl)2 ethyl amide I-28 C(methyl)2 O-methyl amide I-29 C(methyl)2 C(O)OH amide I-30 C(methyl)2 C(O)CH3 amide I-31 C(methyl)2 C(O)C3H7 amide I-32 C(methyl)2 C(O)O-methyl amide I-33 O H OR2 I-34 O methyl OR2 I-35 O ethyl OR2 I-36 O O-methyl OR2 I-37 O C(O)OH OR2 I-38 O C(O)CH3 OR2 I-39 O C(O)C3H7 OR2 I-40 O C(O)O-methyl OR2 I-41 O H amide I-42 O methyl amide I-43 O ethyl amide I-44 O O-methyl amide I-45 O C(O)OH amide I-46 O C(O)CH3 amide I-47 O C(O)C3H7 amide I-48 O C(O)O-methyl amide I-49 S H OR2 I-50 S methyl OR2 I-51 S ethyl OR2 I-52 S O-methyl OR2 I-53 S C(O)OH OR2 I-54 S C(O)CH3 OR2 I-55 S C(O)C3H7 OR2 I-56 S C(O)O-methyl OR2 I-57 S H amide I-58 S methyl amide I-59 S ethyl amide I-60 S O-methyl amide I-61 S C(O)OH amide I-62 S C(O)CH3 amide I-63 S C(O)C3H7 amide I-64 S C(O)O-methyl amide I-65 SO H OR2 I-66 SO methyl OR2 I-67 SO ethyl OR2 I-68 SO O-methyl OR2 I-69 SO C(O)OH OR2 I-70 SO C(O)CH3 OR2 I-71 SO C(O)C3H7 OR2 I-72 SO C(O)O-methyl OR2 I-73 SO H amide I-74 SO methyl amide I-75 SO ethyl amide I-76 SO O-methyl amide I-77 SO C(O)OH amide I-78 SO C(O)CH3 amide I-79 SO C(O)C3H7 amide I-80 SO C(O)O-methyl amide I-81 SO2 H OR2 I-82 SO2 methyl OR2 I-83 SO2 ethyl OR2 I-84 SO2 O-methyl OR2 I-85 SO2 C(O)OH OR2 I-86 SO2 C(O)CH3 OR2 I-87 SO2 C(O)C3H7 OR2 I-88 SO2 C(O)O-methyl OR2 I-89 SO2 H amide I-90 SO2 methyl amide I-9 SO2 ethyl amide I-92 SO2 O-methyl amide I-93 SO2 C(O)OH amide I-94 SO2 C(O)CH3 amide I-95 SO2 C(O)C3H7 amide I-96 SO2 C(O)O-methyl amide I-97 NH H OR2 I-98 NH methyl OR2 I-99 NH ethyl OR2 I-100 NH O-methyl OR2 I-101 NH C(O)OH OR2 I-102 NH C(O)CH3 OR2 I-103 NH C(O)C3H7 OR2 I-104 NH C(O)O-methyl OR2 I-105 NH H amide I-106 NH methyl amide I-107 NH ethyl amide I-108 NH O-methyl amide I-109 NH C(O)OH amide I-110 NH C(O)CH3 amide I-111 NH C(O)C3H7 amide I-112 NH C(O)O-methyl amide I-113 N(alkyl) H OR2 I-114 N(alkyl) methyl OR2 I-115 N(alkyl) ethyl OR2 I-116 N(alkyl) O-methyl OR2 I-117 N(alkyl) C(O)OH OR2 I-118 N(alkyl) C(O)CH3 OR2 I-119 N(alkyl) C(O)C3H7 OR2 I-120 N(alkyl) C(O)O-methyl OR2 I-121 N(alkyl) H amide I-122 N(alkyl) methyl amide I-123 N(alkyl) ethyl amide I-124 N(alkyl) O-methyl amide I-125 N(alkyl) C(O)OH amide I-126 N(alkyl) C(O)CH3 amide I-127 N(alkyl) C(O)C3H7 amide I-128 N(alkyl) C(O)O-methyl amide [00037] R1 X R2 II-1 CH2 CH2 CH2OH II-2 CH2 CO CH2OH II-3 CH2 O CH2OH II-4 CH2 S CH2OH II-5 CH2 SO CH2OH II-6 CH2 SO2 CH2OH II-7 CH2 NH CH2OH II-8 CH2 N(alkyl) CH2OH II-9 CH2 CH2 C(O)OY II-10 CH2 CO C(O)OY II-11 CH2 O C(O)OY II-12 CH2 S C(O)OY II-13 CH2 SO C(O)OY II-14 CH2 SO2 C(O)OY II-15 CH2 NH C(O)OY II-16 CH2 N(alkyl) C(O)OY II-17 CH2 CH2 C(O)-amide II-18 CH2 CO C(O)-amide II-19 CH2 O C(O)-amide II-20 CH2 S C(O)-amide II-21 CH2 SO C(O)-amide II-22 CH2 SO2 C(O)-amide II-23 CH2 NH C(O)-amide II-24 CH2 N(alkyl) C(O)-amide II-25 C(methyl)2 CH2 CH2OH II-26 C(methyl)2 CO CH2OH II-27 C(methyl)2 O CH2OH II-28 C(methyl)2 S CH2OH II-29 C(methyl)2 SO CH2OH II-30 C(methyl)2 SO2 CH2OH II-31 C(methyl)2 NH CH2OH II-32 C(methyl)2 N(alkyl) CH2OH II-33 C(methyl)2 CH2 C(O)OY II-34 C(methyl)2 CO C(O)OY II-35 C(methyl)2 O C(O)OY II-36 C(methyl)2 S C(O)OY II-37 C(methyl)2 SO C(O)OY II-38 C(methyl)2 SO2 C(O)OY II-39 C(methyl)2 NH C(O)OY II-40 C(methyl)2 N(alkyl) C(O)OY II-41 C(methyl)2 CH2 C(O)-amide II-42 C(methyl)2 CO C(O)-amide II-43 C(methyl)2 C C(O)-amide II-44 C(methyl)2 S C(O)-amide II-45 C(methyl)2 SO C(O)-amide II-46 C(methyl)2 SO2 C(O)-amide II-47 C(methyl)2 NH C(O)-amide II-48 C(methyl)2 N(alkyl) C(O)-amide II-49 O CH2 CH2OH II-50 O CO CH2OH II-51 O O CH2OH II-52 O S CH2OH II-53 O SO CH2OH II-54 O SO2 CH2OH II-55 O NH CH2OH II-56 O N(alkyl) CH2OH II-57 O CH2 C(O)OY II-58 O C0 C(O)OY II-59 O O C(O)OY II-60 O S C(O)OY II-61 O SO C(O)OY II-62 O SO2 C(O)OY II-63 O NH C(O)OY II-64 O N(alkyl) C(O)OY II-65 O CH2 C(O)-amide II-66 O CO C(O)-amide II-67 O O C(O)-amide II-68 O S C(O)-amide II-69 O SO C(O)-amide II-70 O SO2 C(O)-amide II-71 O NH C(O)-amide II-72 O N(alkyl) C(O)-amide II-73 S CH2 CH2OH II-74 S CO CH2OH II-75 S O CH2OH II-76 S S CH2OH II-77 S SO CH2OH II-78 S SO2 CH2OH II-79 S NH CH2OH II-80 S N(alkyl) CH2OH II-81 S CH2 C(O)OY II-82 S CO C(O)OY II-83 S O C(O)OY II-84 S S C(O)OY II-85 S SO C(O)OY II-86 S SO2 C(O)OY II-87 S NH C(O)OY II-88 S N(alkyl) C(O)OY II-89 S CH2 C(O)-amide II-90 S CO C(O)-amide II-91 S O C(O)-amide II-92 S S C(O)-amide II-93 S SO C(O)-amide II-94 S SO2 C(O)-amide II-95 S NH C(O)-amide II-96 S N(alkyl) C(O)-amide II-97 SO CH2 CH2OH II-98 SO CO CH2OH II-99 SO O CH2OH II-100 SO S CH2OH II-101 SO SO CH2OH II-102 SO SO2 CH2OH II-103 SO NH CH2OH II-104 SO N(alkyl) CH2OH II-105 SO CH2 C(O)OY II-106 SO CO C(O)OY II-107 SO O C(O)OY II-108 SO S C(O)OY II-109 SO SO C(O)OY II-110 SO SO2 C(O)OY II-111 SO NH C(O)OY II-112 SO N(alkyl) C(O)OY II-113 SO CH2 C(O)-amide II-114 SO CO C(O)-amide II-115 SO O C(O)-amide II-116 SO S C(O)-amide II-117 SO SO C(O)-amide II-118 SO SO2 C(O)-amide II-119 SO NH C(O)-amide II-120 SO N(alkyl) C(O)-amide II-121 SO2 CH2 CH2OH II-122 SO2 CO CH2OH II-123 SO2 O CH2OH II-124 SO2 S CH2OH II-125 SO2 SO CH2OH II-126 SO2 SO2 CH2OH II-127 SO2 NH CH2OH II-128 SO2 N(alkyl) CH2OH II-129 SO2 CH2 C(O)OY II-130 SO2 CO C(O)OY II-131 SO2 O C(O)OY II-132 SO2 S C(O)OY II-133 SO2 SO C(O)OY II-134 SO2 SO2 C(O)OY II-135 SO2 NH C(O)OY II-136 SO2 N(alkyl) C(O)OY II-137 SO2 CH2 C(O)-amide II-138 SO2 CO C(O)-amide II-139 SO2 O C(O)-amide II-140 SO2 S C(O)-amide II-141 SO2 SO C(O)-amide II-142 SO2 SO2 C(O)-amide II-143 SO2 NH C(O)-amide II-144 SO2 N(alkyl) C(O)-amide II-145 NH CH2 CH2OH II-146 NH CO CH2OH II-147 NH O CH2OH II-148 NH S CH2OH II-149 NH SO CH2OH II-150 NH SO2 CH2OH II-151 NH NH CH2OH II-152 NH N(alkyl) CH2OH II-153 NH CH2 C(O)OY II-154 NH CO C(O)OY II-155 NH O C(O)OY II-156 NH S C(O)OY II-157 NH SO C(O)OY II-158 NH SO2 C(O)OY II-159 NH NH C(O)OY II-160 NH N(alkyl) C(O)OY II-161 NH CH2 C(O)-amide II-162 NH CO C(O)-amide II-163 NH O C(O)-amide II-164 NH S C(O)-amide II-165 NH SO C(O)-amide II-166 NH SO2 C(O)-amide II-167 NH NH C(O)-amide II-168 NH N(alkyl) C(O)-amide II-169 N(alkyl) CH2 CH2OH II-170 N(alkyl) CO CH2OH II-171 N(alkyl) O CH2OH II-172 N(alkyl) S CH2OH II-173 N(alkyl) SO CH2OH II-174 N(alkyl) SO2 CH2OH II-175 N(alkyl) NH CH2OH II-176 N(alkyl) N(alkyl) CH2OH II-177 N(alkyl) CH2 C(O)OY II-178 N(alkyl) CO C(O)OY II-179 N(alkyl) O C(O)OY II-180 N(alkyl) S C(O)OY II-181 N(alkyl) SO C(O)OY II-182 N(alkyl) SO2 C(O)OY II-183 N(alkyl) NH C(O)OY II-184 N(alkyl) N(alkyl) C(O)OY II-185 N(alkyl) CH2 C(O)-amide II-186 N(alkyl) CO C(O)-amide II-187 N(alkyl) O C(O)-amide II-188 N(alkyl) S C(O)-amide II-189 N(alkyl) SO C(O)-amide II-190 N(alkyl) SO2 C(O)-amide II-191 N(alkyl) NH C(O)-amide II-192 N(alkyl) N(alkyl) C(O)-amide
or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds, or any mixture of the afore-mentioned compounds.

[0348] In the mycosporine-like amino acid compounds of Table 1, the phenyl ring may be unsubstituted or substituted. The substituents R4, R5, R6, R4, R5, R6, amide, Y, amide and alkyl have the same meaning as defined for the mycosporine-like amino acid compounds according to general formula (V) or (VI) before.

[0349] Particular preferred are those mycosporine-like amino acid compounds, wherein in the general formula (V) R1 is CH.sub.2 or C(methyl).sub.2 or wherein in the general formula (VI) R1 is CH.sub.2 or C(methyl).sub.2:

TABLE-US-00002 TABLE 2 [00038] R1 R3 Z I-1 CH2 H OR2 I-2 CH2 methyl OR2 I-3 CH2 ethyl OR2 I-4 CH2 O-methyl OR2 I-5 CH2 C(O)OH OR2 I-6 CH2 C(O)CH3 OR2 I-7 CH2 C(O)C3H7 OR2 I-8 CH2 C(O)O-methyl OR2 I-9 CH2 H amide I-10 CH2 methyl amide I-11 CH2 ethyl amide I-12 CH2 O-methyl amide I-13 CH2 C(O)OH amide I-14 CH2 C(O)CH3 amide I-15 CH2 C(O)C3H7 amide I-16 CH2 C(O)O-methyl amide I-17 C(methyl)2 H OR2 I-18 C(methyl)2 methyl OR2 I-19 C(methyl)2 ethyl OR2 I-20 C(methyl)2 O-methyl OR2 I-21 C(methyl)2 C(O)OH OR2 I-22 C(methyl)2 C(O)CH3 OR2 I-23 C(methyl)2 C(O)C3H7 OR2 I-24 C(methyl)2 C(O)O-methyl OR2 I-25 C(methyl)2 H amide I-26 C(methyl)2 methyl amide I-27 C(methyl)2 ethyl amide I-28 C(methyl)2 O-methyl amide I-29 C(methyl)2 C(O)OH amide I-30 C(methyl)2 C(O)CH3 amide I-31 C(methyl)2 C(O)C3H7 amide I-32 C(methyl)2 C(O)O-methyl amide [00039] R1 X R2 II-1 CH2 CH2 CH2OH II-2 CH2 CO CH2OH II-3 CH2 O CH2OH II-4 CH2 S CH2OH II-5 CH2 SO CH2OH II-6 CH2 SO2 CH2OH II-7 CH2 NH CH2OH II-8 CH2 N(alkyl) CH2OH II-9 CH2 CH2 C(O)OY II-10 CH2 CO C(O)OY II-11 CH2 O C(O)OY II-12 CH2 S C(O)OY II-13 CH2 SO C(O)OY II-14 CH2 SO2 C(O)OY II-15 CH2 NH C(O)OY II-16 CH2 N(alkyl) C(O)OY II-17 CH2 CH2 C(O)-amide II-18 CH2 CO C(O)-amide II-19 CH2 O C(O)-amide II-20 CH2 S C(O)-amide II-21 CH2 SO C(O)-amide II-22 CH2 SO2 C(O)-amide II-23 CH2 NH C(O)-amide II-24 CH2 N(alkyl) C(O)-amide II-25 C(methyl)2 CH2 CH2OH II-26 C(methyl)2 CO CH2OH II-27 C(methyl)2 O CH2OH II-28 C(methyl)2 S CH2OH II-29 C(methyl)2 SO CH2OH II-30 C(methyl)2 SO2 CH2OH II-31 C(methyl)2 NH CH2OH II-32 C(methyl)2 N(alkyl) CH2OH II-33 C(methyl)2 CH2 C(O)OY II-34 C(methyl)2 CO C(O)OY II-35 C(methyl)2 O C(O)OY II-36 C(methyl)2 S C(O)OY II-37 C(methyl)2 SO C(O)OY II-38 C(methyl)2 SO2 C(O)OY II-39 C(methyl)2 NH C(O)OY II-40 C(methyl)2 N(alkyl) C(O)OY II-41 C(methyl)2 CH2 C(O)-amide II-42 C(methyl)2 CO C(O)-amide II-43 C(methyl)2 O C(O)-amide II-44 C(methyl)2 S C(O)-amide II-45 C(methyl)2 SO C(O)-amide II-46 C(methyl)2 SO2 C(O)-amide II-47 C(methyl)2 NH C(O)-amide II-48 C(methyl)2 N(alkyl) C(O)-amide
or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds, or any mixture of the afore-mentioned compounds.

[0350] In the mycosporine-like amino acid compounds of Table 2, the phenyl ring may be unsubstituted or substituted. The substituents R4, R5, R6, R4, R5, R6, amide, Y, amide and alkyl have the same meaning as defined for the mycosporine-like amino acid compounds according to general formula (V) or (VI) before.

[0351] Preferably, in the mycosporine-like amino acid compounds according to the general formulae (V) and formula (V) specified in Table 1 and Table 2 [0352] R2 is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00040## (2-ethylhexyl) and phenyl; [0353] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); [0354] Y is selected from the group consisting of H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl,

##STR00041## (2-ethylhexyl) and phenyl; [0355] amide is selected from the group consisting of NH.sub.2, NH(alkyl), N(alkyl).sub.2, N(O-alkyl)(alkyl) (Weinreb amide) and N(OH)(H) (hydroxamate); and [0356] alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0357] In a most preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formula (V) and its variants or formula (VI) and its variants, wherein R1 or R1 are CH.sub.2. Such mycosporine-like amino acid compounds have a particular good water solubility.

[0358] In a still further preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (VI), (IX), (X) and their variants, wherein X is selected from the group consisting of S, SO, and SO.sub.2.

[0359] In a still more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (VI), (IX), (X) and their variants, wherein X is S. However, the S atom in said compounds is prone to oxidation.

[0360] In a most preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (VI), (IX), (X) and their variants, wherein X is either SO or SO.sub.2. Such mycosporine-like amino acid compounds are particular stable, due to their oxidation state.

[0361] In a still further preferred variant according to the present invention, in the general formulae (V) to (X) and their variants, n is 1.

[0362] In a more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formula (V), wherein [0363] Z is OR2 or amide; and/or [0364] R1 is either CH.sub.2 or C(methyl).sub.2; and/or [0365] R2 is either H or ethyl or isopropyl or 2-ethylhexyl or phenyl; or [0366] amide is either NH.sub.2 or N(methyl).sub.2 or N (ethyl).sub.2 orN(O-alkyl)(alkyl) (Weinreb amide) orN(OH)(H) (hydroxamate); and/or [0367] R3 is either H or O-methyl or C(O)OH or C(O)CH.sub.3 or C(O)O-methyl; and/or [0368] the substituents R4, R5 and R6 have the same meaning as defined for formula (V); [0369] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0370] In a more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formulae (VII) or (VIII), wherein [0371] R1 is either CH.sub.2 or C(methyl).sub.2; and/or [0372] R2 is either H or ethyl or isopropyl or 2-ethylhexyl or phenyl; or [0373] amide is either NH.sub.2 or N(methyl).sub.2 or N (ethyl).sub.2 orN(O-alkyl)(alkyl) (Weinreb amide) orN(OH)(H) (hydroxamate); and/or [0374] R3 is either H or O-methyl or C(O)OH or C(O)CH.sub.3 or C(O)O-methyl; and/or [0375] the substituents R4, R5 and R6 have the same meaning as defined for formula (V); [0376] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and tert-butyl.

[0377] In a more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid compound is a compound according to general formula (VI), wherein [0378] R1 is either CH.sub.2 or C(methyl).sub.2; and/or [0379] R2 is either-C(O)OY, or C(O)-amide; and/or [0380] X is S, SO or SO.sub.2; and/or [0381] Y is either H or ethyl or isopropyl or 2-ethylhexyl or phenyl; or [0382] amide is either NH.sub.2 or N(methyl).sub.2 or N (ethyl).sub.2 orN(O-alkyl)(alkyl) (Weinreb amide) orN(OH)(H) (hydroxamate); and/or [0383] the substituents R4, R5 and R6 have the same meaning as defined for formula (VI); [0384] wherein alkyl is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, and butyl.

[0385] The phenyl ring in the mycosporine-like amino acid compounds according to the general formulae (V) to (X) and their variants can be unsubstituted or substituted.

[0386] In a preferred variant, the phenyl ring in the mycosporine-like amino acid compounds according to the general formulae (V) to (X) and their variants is unsubstituted, i.e. the substituents R4, R5 and R6 on the phenyl ring in the general formula (V) is H; or the substituents R4, R5 and R6 on the phenyl ring in the general formula (VI) is H.

[0387] In a further preferred variant, the phenyl ring in the mycosporine-like amino acid compounds according to the general formulae (V) to (X) and their variants is substituted.

[0388] Most preferred, the phenyl ring in the mycosporine-like amino acid compounds according to the general formulae (V), (VII), (VIII) and their variants is unsubstituted, i.e. the substituents R4, R5 and R6 are each H. Alternatively, most preferred, the phenyl ring in the mycosporine-like amino acid compounds according to the general formula (VI), (IX), (X) and their variants is unsubstituted, i.e. the substituents R4, R5 and R6 are each H. Said compounds have an improved water solubility.

[0389] Preferably, the phenyl ring in the mycosporine-like amino acid compounds according to the general formulae (V) to (X) and their variants is monosubstituted, disubstituted or trisubstituted.

[0390] In a still more preferred variant according to the first aspect of the present invention, the mycosporine-like amino acid is a compound according to general formulae (V), (VII), (VIII) and their variants, wherein the substituents R4, R5 and R6 which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, preferably methyl, ethyl, propyl, iso-propyl, butyl, isobutyl or tert.-butyl, alkoxy, preferably, O-methyl, O-ethyl, or O-butyl, S(O).sub.2OH, and sulfonyl.

[0391] Still more preferred, the substituents R4, R5 and R6 in the general formulae (V), (VII), (VIII) and their variants, which may be identical or different, are independently from each other selected from the group consisting of H, OH, methyl, O-methyl, S(O).sub.2OH, and sulfonyl.

[0392] Alternatively, the mycosporine-like amino acid compound is a compound according to general formulae (VI), (IX), (X) and their variants, wherein the substituents R4, R5 and R6, which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, preferably methyl, ethyl, propyl, iso-propyl, butyl, isobutyl, tert-butyl, alkoxy, preferably O-methyl, O-ethyl, or O-butyl, S(O).sub.2OH, and sulfonyl.

[0393] Still more preferred, the substituents R4, R5 and R6 in the general formula (VI), (IX), (X) and their variants, which may be identical or different, are independently from each other selected from the group consisting of H, OH, methyl, O-methyl, S(O).sub.2OH, and sulfonyl.

[0394] In the general formulae (V) to (X) and their variants, the following substitution patterns are particularly preferred: [0395] R4=H and R5=H and R6=H; or [0396] R4=H and R5=H and R6=OH; or [0397] R4=H and R5=H and R6=methyl; or [0398] R4=H and R5=H and R6=O-methyl; or [0399] R4=H and R5=H and R6=S(O).sub.2OH; or [0400] R4=H and R5=H and R6=sulfonyl; or [0401] R4=H and R5=OH and R6=H; or [0402] R4=H and R5=OH and R6=OH; or [0403] R4=H and R5=OH and R6=methyl; or [0404] R4=H and R5=OH and R6=O-methyl; or [0405] R4=H and R5=OH and R6=S(O).sub.2OH; or [0406] R4=H and R5=OH and R6=sulfonyl; or [0407] R4=H and R5=methyl and R6=H; or [0408] R4=H and R5=methyl and R6=OH; or [0409] R4=H and R5=methyl and R6=methyl; or [0410] R4=H and R5=methyl and R6=O-methyl; or [0411] R4=H and R5=methyl and R6=S(O).sub.2OH; or [0412] R4=H and R5=methyl and R6=sulfonyl; or [0413] R4=H and R5=O-methyl and R6=H; or [0414] R4=H and R5=O-methyl and R6=OH; or [0415] R4=H and R5=O-methyl and R6=methyl; or [0416] R4=H and R5=O-methyl and R6=O-methyl; or [0417] R4=H and R5=O-methyl and R6=S(O).sub.2OH; or [0418] R4=H and R5=O-methyl and R6=sulfonyl; or [0419] R4=H and R5=S(O).sub.2OH and R6=H; or [0420] R4=H and R5=S(O).sub.2OH and R6=OH; or [0421] R4=H and R5=S(O).sub.2OH and R6=methyl; or [0422] R4=H and R5=S(O).sub.2OH and R6=O-methyl; or [0423] R4=H and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0424] R4=H and R5=S(O).sub.2OH and R6=sulfonyl; or [0425] R4=H and R5=sulfonyl and R6=H; or [0426] R4=H and R5=sulfonyl and R6=OH; or [0427] R4=H and R5=sulfonyl and R6=methyl; or [0428] R4=H and R5=sulfonyl and R6=O-methyl; or [0429] R4=H and R5=sulfonyl and R6=S(O).sub.2OH; or [0430] R4=H and R5=sulfonyl and R6=sulfonyl; or [0431] R4=OH and R5=H and R6=H; or [0432] R4=OH and R5=H and R6=OH; or [0433] R4=OH and R5=H and R6=methyl; or [0434] R4=OH and R5=H and R6=O-methyl; or [0435] R4=OH and R5=H and R6=S(O).sub.2OH; or [0436] R4=OH and R5=H and R6=sulfonyl; or [0437] R4=OH and R5=OH and R6=H; or [0438] R4=OH and R5=OH and R6=OH; or [0439] R4=OH and R5=OH and R6=methyl; or [0440] R4=OH and R5=OH and R6=O-methyl; or [0441] R4=OH and R5=OH and R6=S(O).sub.20H; or [0442] R4=OH and R5=OH and R6=sulfonyl; or [0443] R4=OH and R5=methyl and R6=H; or [0444] R4=OH and R5=methyl and R6=OH; or [0445] R4=OH and R5=methyl and R6=methyl; or [0446] R4=OH and R5=methyl and R6=O-methyl; or [0447] R4=OH and R5=methyl and R6=S(O).sub.2OH; or [0448] R4=OH and R5=methyl and R6=sulfonyl; or [0449] R4=OH and R5=O-methyl and R6=H; or [0450] R4=OH and R5=O-methyl and R6=OH; or [0451] R4=OH and R5=O-methyl and R6=methyl; or [0452] R4=OH and R5=O-methyl and R6=O-methyl; or [0453] R4=OH and R5=O-methyl and R6=S(O).sub.2OH; or [0454] R4=OH and R5=O-methyl and R6=sulfonyl; or [0455] R4=OH and R5=S(O).sub.2OH and R6=H; or [0456] R4=OH and R5=S(O).sub.2OH and R6=OH; or [0457] R4=OH and R5=S(O).sub.2OH and R6=methyl; or [0458] R4=OH and R5=S(O).sub.2OH and R6=O-methyl; or [0459] R4=OH and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0460] R4=OH and R5=S(O).sub.2OH and R6=sulfonyl; or [0461] R4=OH and R5=sulfonyl and R6=H; or [0462] R4=OH and R5=sulfonyl and R6=OH; or [0463] R4=OH and R5=sulfonyl and R6=methyl; or [0464] R4=OH and R5=sulfonyl and R6=O-methyl; or [0465] R4=OH and R5=sulfonyl and R6=S(O).sub.2OH; or [0466] R4=OH and R5=sulfonyl and R6=sulfonyl; or [0467] R4=methyl and R5=H and R6=H; or [0468] R4=methyl and R5=H and R6=OH; or [0469] R4=methyl and R5=H and R6=methyl; or [0470] R4=methyl and R5=H and R6=O-methyl; or [0471] R4=methyl and R5=H and R6=S(O).sub.2OH; or [0472] R4=methyl and R5=H and R6=sulfonyl; or [0473] R4=methyl and R5=OH and R6=H; or [0474] R4=methyl and R5=OH and R6=OH; or [0475] R4=methyl and R5=OH and R6=methyl; or [0476] R4=methyl and R5=OH and R6=O-methyl; or [0477] R4=methyl and R5=OH and R6=S(O).sub.2OH; or [0478] R4=methyl and R5=OH and R6=sulfonyl; or [0479] R4=methyl and R5=methyl and R6=H; or [0480] R4=methyl and R5=methyl and R6=OH; or [0481] R4=methyl and R5=methyl and R6=methyl; or [0482] R4=methyl and R5=methyl and R6=O-methyl; or [0483] R4=methyl and R5=methyl and R6=S(O).sub.20H; or [0484] R4=methyl and R5=methyl and R6=sulfonyl; or [0485] R4=methyl and R5=O-methyl and R6=H; or [0486] R4=methyl and R5=O-methyl and R6=OH; or [0487] R4=methyl and R5=O-methyl and R6=methyl; or [0488] R4=methyl and R5=O-methyl and R6=O-methyl; or [0489] R4=methyl and R5=O-methyl and R6=S(O).sub.2OH; or [0490] R4=methyl and R5=O-methyl and R6=sulfonyl; or [0491] R4=methyl and R5=S(O).sub.2OH and R6=H; or [0492] R4=methyl and R5=S(O).sub.2OH and R6=OH; or [0493] R4=methyl and R5=S(O).sub.2OH and R6=methyl; or [0494] R4=methyl and R5=S(O).sub.2OH and R6=O-methyl; or [0495] R4=methyl and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0496] R4=methyl and R5=S(O).sub.2OH and R6=sulfonyl; or [0497] R4=methyl and R5=sulfonyl and R6=H; or [0498] R4=methyl and R5=sulfonyl and R6=OH; or [0499] R4=methyl and R5=sulfonyl and R6=methyl; or [0500] R4=methyl and R5=sulfonyl and R6=O-methyl; or [0501] R4=methyl and R5=sulfonyl and R6=S(O).sub.2OH; or [0502] R4=methyl and R5=sulfonyl and R6=sulfonyl; or [0503] R4=O-methyl and R5=H and R6=H; or [0504] R4=O-methyl and R5=H and R6=OH; or [0505] R4=O-methyl and R5=H and R6=methyl; or [0506] R4=O-methyl and R5=H and R6=O-methyl; or [0507] R4=O-methyl and R5=H and R6=S(O).sub.2OH; or [0508] R4=O-methyl and R5=H and R6=sulfonyl; or [0509] R4=O-methyl and R5=OH and R6=H; or [0510] R4=O-methyl and R5=OH and R6=OH; or [0511] R4=O-methyl and R5=OH and R6=methyl; or [0512] R4=O-methyl and R5=OH and R6=O-methyl; or [0513] R4=O-methyl and R5=OH and R6=S(O).sub.2OH; or [0514] R4=O-methyl and R5=OH and R6=sulfonyl; or [0515] R4=O-methyl and R5=methyl and R6=H; or [0516] R4=O-methyl and R5=methyl and R6=OH; or [0517] R4=O-methyl and R5=methyl and R6=methyl; or [0518] R4=O-methyl and R5=methyl and R6=O-methyl; or [0519] R4=O-methyl and R5=methyl and R6=S(O).sub.2OH; or [0520] R4=O-methyl and R5=methyl and R6=sulfonyl; or [0521] R4=O-methyl and R5=O-methyl and R6=H; or [0522] R4=O-methyl and R5=O-methyl and R6=OH; or [0523] R4=O-methyl and R5=O-methyl and R6=methyl; or [0524] R4=O-methyl and R5=O-methyl and R6=O-methyl; or [0525] R4=O-methyl and R5=O-methyl and R6=S(O).sub.2OH; or [0526] R4=O-methyl and R5=O-methyl and R6=sulfonyl; or [0527] R4=O-methyl and R5=S(O).sub.2OH and R6=H; or [0528] R4=O-methyl and R5=S(O).sub.2OH and R6=OH; or [0529] R4=O-methyl and R5=S(O).sub.2OH and R6=methyl; or [0530] R4=O-methyl and R5=S(O).sub.2OH and R6=O-methyl; or [0531] R4=O-methyl and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0532] R4=O-methyl and R5=S(O).sub.2OH and R6=sulfonyl; or [0533] R4=O-methyl and R5=sulfonyl and R6=H; or [0534] R4=O-methyl and R5=sulfonyl and R6=OH; or [0535] R4=O-methyl and R5=sulfonyl and R6=methyl; or [0536] R4=O-methyl and R5=sulfonyl and R6=O-methyl; or [0537] R4=O-methyl and R5=sulfonyl and R6=S(O).sub.2OH; or [0538] R4=O-methyl and R5=sulfonyl and R6=sulfonyl; or [0539] R4=S(O).sub.2OH and R5=H and R6=H; or [0540] R4=S(O).sub.2OH and R5=H and R6=OH; or [0541] R4=S(O).sub.2OH and R5=H and R6=methyl; or [0542] R4=S(O).sub.2OH and R5=H and R6=O-methyl; or [0543] R4=S(O).sub.2OH and R5=H and R6=S(O).sub.2OH; or [0544] R4=S(O).sub.2OH and R5=H and R6=sulfonyl; or [0545] R4=S(O).sub.2OH and R5=OH and R6=H; or [0546] R4=S(O).sub.2OH and R5=OH and R6=OH; or [0547] R4=S(O).sub.2OH and R5=OH and R6=methyl; or [0548] R4=S(O).sub.2OH and R5=OH and R6=O-methyl; or [0549] R4=S(O).sub.2OH and R5=OH and R6=S(O).sub.2OH; or [0550] R4=S(O).sub.2OH and R5=OH and R6=sulfonyl; or [0551] R4=S(O).sub.2OH and R5=methyl and R6=H; or [0552] R4=S(O).sub.2OH and R5=methyl and R6=OH; or [0553] R4=S(O).sub.2OH and R5=methyl and R6=methyl; or [0554] R4=S(O).sub.2OH and R5=methyl and R6=O-methyl; or [0555] R4=S(O).sub.2OH and R5=methyl and R6=S(O).sub.2OH; or [0556] R4=S(O).sub.2OH and R5=methyl and R6=sulfonyl; or [0557] R4=S(O).sub.2OH and R5=O-methyl and R6=H; or [0558] R4=S(O).sub.2OH and R5=O-methyl and R6=OH; or [0559] R4=S(O).sub.2OH and R5=O-methyl and R6=methyl; or [0560] R4=S(O).sub.2OH and R5=O-methyl and R6=O-methyl; or [0561] R4=S(O).sub.2OH and R5=O-methyl and R6=S(O).sub.2OH; or [0562] R4=S(O).sub.2OH and R5=O-methyl and R6=sulfonyl; or [0563] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=H; or [0564] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=OH; or [0565] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=methyl; or [0566] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=O-methyl; or [0567] R4=S(O).sub.2OH and R5=sulfonyl= and R6=H; or [0568] R4=S(O).sub.2OH and R5=sulfonyl and R6=OH; or [0569] R4=S(O).sub.2OH and R5=sulfonyl and R6=methyl; or [0570] R4=S(O).sub.2OH and R5=sulfonyl and R6=O-methyl; or [0571] R4=sulfonyl and R5=H and R6=H; or [0572] R4=sulfonyl and R5=H and R6=OH; or [0573] R4=sulfonyl and R5=H and R6=methyl; or [0574] R4=sulfonyl and R5=H and R6=O-methyl; or [0575] R4=sulfonyl and R5=H and R6=S(O).sub.2OH; or [0576] R4=sulfonyl and R5=H and R6=sulfonyl; or [0577] R4=sulfonyl and R5=OH and R6=H; or [0578] R4=sulfonyl and R5=OH and R6=OH; or [0579] R4=sulfonyl and R5=OH and R6=methyl; or [0580] R4=sulfonyl and R5=OH and R6=O-methyl; or [0581] R4=sulfonyl and R5=OH and R6=S(O).sub.2OH; or [0582] R4=sulfonyl and R5=OH and R6=sulfonyl; or [0583] R4=sulfonyl and R5=methyl and R6=H; or [0584] R4=sulfonyl and R5=methyl and R6=OH; or [0585] R4=sulfonyl and R5=methyl and R6=methyl; or [0586] R4=sulfonyl and R5=methyl and R6=O-methyl; or [0587] R4=sulfonyl and R5=methyl and R6=S(O).sub.2OH; or [0588] R4=sulfonyl and R5=methyl and R6=sulfonyl; or [0589] R4=sulfonyl and R5=O-methyl and R6=H; or [0590] R4=sulfonyl and R5=O-methyl and R6=OH; or [0591] R4=sulfonyl and R5=O-methyl and R6=methyl; or [0592] R4=sulfonyl and R5=O-methyl and R6=O-methyl; or [0593] R4=sulfonyl and R5=O-methyl and R6=S(O).sub.2OH; or [0594] R4=sulfonyl and R5=O-methyl and R6=sulfonyl; or [0595] R4=sulfonyl and R5=S(O).sub.2OH and R6=H; or [0596] R4=sulfonyl and R5=S(O).sub.2OH and R6=OH; or [0597] R4=sulfonyl and R5=S(O).sub.2OH and R6=methyl; or [0598] R4=sulfonyl and R5=S(O).sub.2OH and R6=O-methyl; or [0599] R4=sulfonyl and R5=sulfonyl and R6=H; or [0600] R4=sulfonyl and R5=sulfonyl and R6=OH; or [0601] R4=sulfonyl and R5=sulfonyl and R6=methyl; or [0602] R4=sulfonyl and R5=sulfonyl and R6=O-methyl; or [0603] R4=H and R5=H and R6=H; or [0604] R4=H and R5=H and R6=OH; or [0605] R4=H and R5=H and R6=methyl; or [0606] R4=H and R5=H and R6=O-methyl; or [0607] R4=H and R5=H and R6=S(O).sub.2OH; or [0608] R4=H and R5=H and R6=sulfonyl; or [0609] R4=H and R5=OH and R6=H; or [0610] R4=H and R5=OH and R6=OH; or [0611] R4=H and R5=OH and R6=methyl; or [0612] R4=H and R5=OH and R6=O-methyl; or [0613] R4=H and R5=OH and R6=S(O).sub.2OH; or [0614] R4=H and R5=OH and R6=sulfonyl; or [0615] R4=H and R5=methyl and R6=H; or [0616] R4=H and R5=methyl and R6=OH; or [0617] R4=H and R5=methyl and R6=methyl; or [0618] R4=H and R5=methyl and R6=O-methyl; or [0619] R4=H and R5=methyl and R6=S(O).sub.2OH; or [0620] R4=H and R5=methyl and R6=sulfonyl; or [0621] R4=H and R5=O-methyl and R6=H; or [0622] R4=H and R5=O-methyl and R6=OH; or [0623] R4=H and R5=O-methyl and R6=methyl; or [0624] R4=H and R5=O-methyl and R6=O-methyl; or [0625] R4=H and R5=O-methyl and R6=S(O).sub.2OH; or [0626] R4=H and R5=O-methyl and R6=sulfonyl; or [0627] R4=H and R5=S(O).sub.2OH and R6=H; or [0628] R4=H and R5=S(O).sub.2OH and R6=OH; or [0629] R4=H and R5=S(O).sub.2OH and R6=methyl; or [0630] R4=H and R5=S(O).sub.2OH and R6=O-methyl; or [0631] R4=H and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0632] R4=H and R5=S(O).sub.2OH and R6=sulfonyl; or [0633] R4=H and R5=sulfonyl and R6=H; or [0634] R4=H and R5=sulfonyl and R6=OH; or [0635] R4=H and R5=sulfonyl and R6=methyl; or [0636] R4=H and R5=sulfonyl and R6=O-methyl; or [0637] R4=H and R5=sulfonyl and R6=S(O).sub.2OH; or [0638] R4=H and R5=sulfonyl and R6=sulfonyl; or [0639] R4=OH and R5=H and R6=H; or [0640] R4=OH and R5=H and R6=OH; or [0641] R4=OH and R5=H and R6=methyl; or [0642] R4=OH and R5=H and R6=O-methyl; or [0643] R4=OH and R5=H and R6=S(O).sub.2OH; or [0644] R4=OH and R5=H and R6=sulfonyl; or [0645] R4=OH and R5=OH and R6=H; or [0646] R4=OH and R5=OH and R6=OH; or [0647] R4=OH and R5=OH and R6=methyl; or [0648] R4=OH and R5=OH and R6=O-methyl; or [0649] R4=OH and R5=OH and R6=S(O).sub.2OH; or [0650] R4=OH and R5=OH and R6=sulfonyl; or [0651] R4=OH and R5=methyl and R6=H; or [0652] R4=OH and R5=methyl and R6=OH; or [0653] R4=OH and R5=methyl and R6=methyl; or [0654] R4=OH and R5=methyl and R6=O-methyl; or [0655] R4=OH and R5=methyl and R6=S(O).sub.2OH; or [0656] R4=OH and R5=methyl and R6=sulfonyl; or [0657] R4=OH and R5=O-methyl and R6=H; or [0658] R4=OH and R5=O-methyl and R6=OH; or [0659] R4=OH and R5=O-methyl and R6=methyl; or [0660] R4=OH and R5=O-methyl and R6=O-methyl; or [0661] R4=OH and R5=O-methyl and R6=S(O).sub.2OH; or [0662] R4=OH and R5=O-methyl and R6=sulfonyl; or [0663] R4=OH and R5=S(O).sub.2OH and R6=H; or [0664] R4=OH and R5=S(O).sub.2OH and R6=OH; or [0665] R4=OH and R5=S(O).sub.2OH and R6=methyl; or [0666] R4=OH and R5=S(O).sub.2OH and R6=O-methyl; or [0667] R4=OH and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0668] R4=OH and R5=S(O).sub.2OH and R6=sulfonyl; or [0669] R4=OH and R5=sulfonyl and R6=H; or [0670] R4=OH and R5=sulfonyl and R6=OH; or [0671] R4=OH and R5=sulfonyl and R6=methyl; or [0672] R4=OH and R5=sulfonyl and R6=O-methyl; or [0673] R4=OH and R5=sulfonyl and R6=S(O).sub.2OH; or [0674] R4=OH and R5=sulfonyl and R6=sulfonyl; or [0675] R4=methyl and R5=H and R6=H; or [0676] R4=methyl and R5=H and R6=OH; or [0677] R4=methyl and R5=H and R6=methyl; or [0678] R4=methyl and R5=H and R6=O-methyl; or [0679] R4=methyl and R5=H and R6=S(O).sub.2OH; or [0680] R4=methyl and R5=H and R6=sulfonyl; or [0681] R4=methyl and R5=OH and R6=H; or [0682] R4=methyl and R5=OH and R6=OH; or [0683] R4=methyl and R5=OH and R6=methyl; or [0684] R4=methyl and R5=OH and R6=O-methyl; or [0685] R4=methyl and R5=OH and R6=S(O).sub.2OH; or [0686] R4=methyl and R5=OH and R6=sulfonyl; or [0687] R4=methyl and R5=methyl and R6=H; or [0688] R4=methyl and R5=methyl and R6=OH; or [0689] R4=methyl and R5=methyl and R6=methyl; or [0690] R4=methyl and R5=methyl and R6=O-methyl; or [0691] R4=methyl and R5=methyl and R6=S(O).sub.2OH; or [0692] R4=methyl and R5=methyl and R6=sulfonyl; or [0693] R4=methyl and R5=O-methyl and R6=H; or [0694] R4=methyl and R5=O-methyl and R6=OH; or [0695] R4=methyl and R5=O-methyl and R6=methyl; or [0696] R4=methyl and R5=O-methyl and R6=O-methyl; or [0697] R4=methyl and R5=O-methyl and R6=S(O).sub.2OH; or [0698] R4=methyl and R5=O-methyl and R6=sulfonyl; or [0699] R4=methyl and R5=S(O).sub.2OH and R6=H; or [0700] R4=methyl and R5=S(O).sub.2OH and R6=OH; or [0701] R4=methyl and R5=S(O).sub.2OH and R6=methyl; or [0702] R4=methyl and R5=S(O).sub.2OH and R6=O-methyl; or [0703] R4=methyl and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0704] R4=methyl and R5=S(O).sub.2OH and R6=sulfonyl; or [0705] R4=methyl and R5=sulfonyl and R6=H; or [0706] R4=methyl and R5=sulfonyl and R6=OH; or [0707] R4=methyl and R5=sulfonyl and R6=methyl; or [0708] R4=methyl and R5=sulfonyl and R6=O-methyl; or [0709] R4=methyl and R5=sulfonyl and R6=S(O).sub.2OH; or [0710] R4=methyl and R5=sulfonyl and R6=sulfonyl; or [0711] R4=O-methyl and R5=H and R6=H; or [0712] R4=O-methyl and R5=H and R6=OH; or [0713] R4=O-methyl and R5=H and R6=methyl; or [0714] R4=O-methyl and R5=H and R6=O-methyl; or [0715] R4=O-methyl and R5=H and R6=S(O).sub.2OH; or [0716] R4=O-methyl and R5=H and R6=sulfonyl; or [0717] R4=O-methyl and R5=OH and R6=H; or [0718] R4=O-methyl and R5=OH and R6=OH; or [0719] R4=O-methyl and R5=OH and R6=methyl; or [0720] R4=O-methyl and R5=OH and R6=O-methyl; or [0721] R4=O-methyl and R5=OH and R6=S(O).sub.2OH; or [0722] R4=O-methyl and R5=OH and R6=sulfonyl; or [0723] R4=O-methyl and R5=methyl and R6=H; or [0724] R4=O-methyl and R5=methyl and R6=OH; or [0725] R4=O-methyl and R5=methyl and R6=methyl; or [0726] R4=O-methyl and R5=methyl and R6=O-methyl; or [0727] R4=O-methyl and R5=methyl and R6=S(O).sub.2OH; or [0728] R4=O-methyl and R5=methyl and R6=sulfonyl; or [0729] R4=O-methyl and R5=O-methyl and R6=H; or [0730] R4=O-methyl and R5=O-methyl and R6=OH; or [0731] R4=O-methyl and R5=O-methyl and R6=methyl; or [0732] R4=O-methyl and R5=O-methyl and R6=O-methyl; or [0733] R4=O-methyl and R5=O-methyl and R6=S(O).sub.2OH; or [0734] R4=O-methyl and R5=O-methyl and R6=sulfonyl; or [0735] R4=O-methyl and R5=S(O).sub.2OH and R6=H; or [0736] R4=O-methyl and R5=S(O).sub.2OH and R6=OH; or [0737] R4=O-methyl and R5=S(O).sub.2OH and R6=methyl; or [0738] R4=O-methyl and R5=S(O).sub.2OH and R6=O-methyl; or [0739] R4=O-methyl and R5=S(O).sub.2OH and R6=S(O).sub.2OH; or [0740] R4=O-methyl and R5=S(O).sub.2OH and R6=sulfonyl; or [0741] R4=O-methyl and R5=sulfonyl and R6=H; or [0742] R4=O-methyl and R5=sulfonyl and R6=OH; or [0743] R4=O-methyl and R5=sulfonyl and R6=methyl; or [0744] R4=O-methyl and R5=sulfonyl and R6=O-methyl; or [0745] R4=O-methyl and R5=sulfonyl and R6=S(O).sub.2OH; or [0746] R4=O-methyl and R5=sulfonyl and R6=sulfonyl; or [0747] R4=S(O).sub.2OH and R5=H and R6=H; or [0748] R4=S(O).sub.2OH and R5=H and R6=OH; or [0749] R4=S(O).sub.2OH and R5=H and R6=methyl; or [0750] R4=S(O).sub.2OH and R5=H and R6=O-methyl; or [0751] R4=S(O).sub.2OH and R5=H and R6=S(O).sub.2OH; or [0752] R4=S(O).sub.2OH and R5=H and R6=sulfonyl; or [0753] R4=S(O).sub.2OH and R5=OH and R6=H; or [0754] R4=S(O).sub.2OH and R5=OH and R6=OH; or [0755] R4=S(O).sub.2OH and R5=OH and R6=methyl; or [0756] R4=S(O).sub.2OH and R5=OH and R6=O-methyl; or [0757] R4=S(O).sub.2OH and R5=OH and R6=S(O).sub.2OH; or [0758] R4=S(O).sub.2OH and R5=OH and R6=sulfonyl; or [0759] R4=S(O).sub.2OH and R5=methyl and R6=H; or [0760] R4=S(O).sub.2OH and R5=methyl and R6=OH; or [0761] R4=S(O).sub.2OH and R5=methyl and R6=methyl; or [0762] R4=S(O).sub.2OH and R5=methyl and R6=O-methyl; or [0763] R4=S(O).sub.2OH and R5=methyl and R6=S(O).sub.2OH; or [0764] R4=S(O).sub.2OH and R5=methyl and R6=sulfonyl; or [0765] R4=S(O).sub.2OH and R5=O-methyl and R6=H; or [0766] R4=S(O).sub.2OH and R5=O-methyl and R6=OH; or [0767] R4=S(O).sub.2OH and R5=O-methyl and R6=methyl; or [0768] R4=S(O).sub.2OH and R5=O-methyl and R6=O-methyl; or [0769] R4=S(O).sub.2OH and R5=O-methyl and R6=S(O).sub.2OH; or [0770] R4=S(O).sub.2OH and R5=O-methyl and R6=sulfonyl; or [0771] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=H; or [0772] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=OH; or [0773] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=methyl; or [0774] R4=S(O).sub.2OH and R5=S(O).sub.2OH and R6=O-methyl; or [0775] R4=S(O).sub.2OH and R5=sulfonyl= and R6=H; or [0776] R4=S(O).sub.2OH and R5=sulfonyl and R6=OH; or [0777] R4=S(O).sub.2OH and R5=sulfonyl and R6=methyl; or [0778] R4=S(O).sub.2OH and R5=sulfonyl and R6=O-methyl; or [0779] R4=sulfonyl and R5=H and R6=H; or [0780] R4=sulfonyl and R5=H and R6=OH; or [0781] R4=sulfonyl and R5=H and R6=methyl; or [0782] R4=sulfonyl and R5=H and R6=O-methyl; or [0783] R4=sulfonyl and R5=H and R6=S(O).sub.2OH; or [0784] R4=sulfonyl and R5=H and R6=sulfonyl; or [0785] R4=sulfonyl and R5=OH and R6=H; or [0786] R4=sulfonyl and R5=OH and R6=OH; or [0787] R4=sulfonyl and R5=OH and R6=methyl; or [0788] R4=sulfonyl and R5=OH and R6=O-methyl; or [0789] R4=sulfonyl and R5=OH and R6=S(O).sub.2OH; or [0790] R4=sulfonyl and R5=OH and R6=sulfonyl; or [0791] R4=sulfonyl and R5=methyl and R6=H; or [0792] R4=sulfonyl and R5=methyl and R6=OH; or [0793] R4=sulfonyl and R5=methyl and R6=methyl; or [0794] R4=sulfonyl and R5=methyl and R6=O-methyl; or [0795] R4=sulfonyl and R5=methyl and R6=S(O).sub.2OH; or [0796] R4=sulfonyl and R5=methyl and R6=sulfonyl; or [0797] R4=sulfonyl and R5=O-methyl and R6=H; or [0798] R4=sulfonyl and R5=O-methyl and R6=OH; or [0799] R4=sulfonyl and R5=O-methyl and R6=methyl; or [0800] R4=sulfonyl and R5=O-methyl and R6=O-methyl; or [0801] R4=sulfonyl and R5=O-methyl and R6=S(O).sub.2OH; or [0802] R4=sulfonyl and R5=O-methyl and R6=sulfonyl; or [0803] R4=sulfonyl and R5=S(O).sub.2OH and R6=H; or [0804] R4=sulfonyl and R5=S(O).sub.2OH and R6=OH; or [0805] R4=sulfonyl and R5=S(O).sub.2OH and R6=methyl; or [0806] R4=sulfonyl and R5=S(O).sub.2OH and R6=O-methyl; or [0807] R4=sulfonyl and R5=sulfonyl and R6=H; or [0808] R4=sulfonyl and R5=sulfonyl and R6=OH; or [0809] R4=sulfonyl and R5=sulfonyl and R6=methyl; or [0810] R4=sulfonyl and R5=sulfonyl and R6=O-methyl.

[0811] In the general formulae (V) to (X) and their variants, the substituted phenyl ring bonded to the imino functionality is preferably selected from the group consisting of

##STR00042##

wherein the dotted line designates the binding site to the cyclohexene imine ring.

[0812] In a still more preferred variant according to the first aspect of the present invention, in the general formulae (V), (VII), (VIII) and their variants, the substituents R4, R5 and R6, which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, preferably methyl, ethyl, propyl, iso-propyl, butyl, isobutyl or tert.-butyl, alkoxy, preferably, O-methyl, O-ethyl or O-butyl, S(O).sub.2OH, and sulfonyl; with the proviso, that if the substituted phenyl ring is monosubstituted, the substituent is either in the ortho or meta-position to the imino-functionality of the general formulae (V), (VI) and (VIII), but not in the para position to the imino-functionality.

[0813] In a still more preferred variant according to the first aspect of the present invention, in the general formulae (VI), (IX), (X) and their variants, the substituents R4, R5 and R6, which may be identical or different, are independently from each other selected from the group consisting of H, OH, alkyl, preferably methyl, ethyl, propyl, iso-propyl, butyl, isobutyl or tert.-butyl, alkoxy, preferably, O-methyl, O-ethyl or O-butyl, S(O).sub.2OH, and sulfonyl; with the proviso, that if the substituted phenyl ring is monosubstituted, the substituent is either in the ortho or meta-position to the imino-functionality of the general formulae (VI), (IX), (X), but not in the para position to the imino-functionality.

[0814] Still more preferred according to the first aspect of the present invention, the food, cosmetic or pharmaceutical preparation or homecare product comprises at least one mycosporine-like amino acid compound selected from the group consisting of:

TABLE-US-00003 TABLE 3 Com- pound Structure INCI/chemical name MAA-1 [00043] ethyl 2-[5,5-dimethyl-3- phenylimino-cyclohexen-1- yl]amino]acetate MAA-2 [00044] ethyl 2-((5,5-dimethyl-3-((4- octyoxy)phenyl)imino)cyclo- hex-1- en-1-yl)amino)acetate MAA-3 [00045] 5,5-dimethyl-3-((4- (octyloxy)phenyl)imino)cyclo- hex- 1-en-1-yl-glycine MAA-4 [00046] ethyl 2-((3-((4- benzoylphenyl)imino)-5,5- dimethylcyclohex-1-en-1- yl)amino)acetate MAA-5 [00047] 3-((4-benzoylphenyl)imino)-5,5- dimethylcyclohex-1-en-1-yl- glycine MAA-6 [00048] ethyl 2-((3-([1,1-biphenyl]-4- ylimino)-5,5-dimethylcyclohex-1- en-1.yl)amino)acetate MAA-7 [00049] 3-([1,1-biphenyl]-4-ylimino)-5,5- dimethylcyclohex-1-en-1-yl- glycine MAA-8 [00050] ethyl 2-((5,5-dimethyl-3-((4- (phenyldiazenyl)phenyl)inino(cy- clohex-1-en-1-yl)ami- no)acetate MAA-9 [00051] 5,5-dimethyl-3-((4-(I-phenyl- diazenyl)phenyl)imino)cyclo- hex-1-en-1-yl-glycine MAA-11 [00052] 3-((4-fluorophenyl)imino)-5,5- dimethylcyclohex-1-en-1-yl- glycine MAA-12 [00053] ethyl 8-((3,4- dimethoyxphenyl)imino)-6,6- dimethyl-3,4,5,6,7,8- hexahydro-2- H-benzol[b][1,4]thiazine-3- carboxylate MAA-13 [00054] 8-((3,4-dimethoyxphenyl)imino)- 6,6-dimethyl-3,4,5,6,7,8- hexahydro-2-H- benzol[b][1,4]thiazine-3- carboxylic acid MAA-14 [00055] ethyl 2-((3-((3,4- dimethoxyphenyl)imino)-5,5- dimethylcyclohex-1-en-1- yl)amino)acetate MAA-16 [00056] ethyl 2-((5,5-dimethyl-3-((4- morpholinophenyl)imino)cyclo- hex-1-en-1-yl)amino)acetate MAA-17 [00057] 5,5-dimethyl-3-((4-morpho- linophenyl)imino)cyclohex- 1-en-1-yl-glycine MAA-20 [00058] 2-[(5,5-dimethyl-3-phenylimino- cyclohexen-1-yl)amino]acetic acid MAA-21 [00059] 2-[(3-phenyliminocyclohexen-1- yl)amino]acetic acid MAA-22 [00060] 2,5,5-trimethyl-3- (phenylimino)cyclohex-1-en-1-yl- glycine MAA-23 [00061] 2-[(2-methyl-3-phenylimino- cyclohexen-1-yl)amino]acetic acid MAA-24 [00062] 3-((3,4-dimethoxyphenyl)imino)- 5,5-dimethylcyclohex-1-en-1-yl- glycine MAA-25 [00063] 3-((3,4-di- methoxyphenyl)imino)cyclohex- 1-en-1-yl-glycine MAA-26 [00064] 3-((3,4-dimethoxyphenyl)imino)- 2,5,5-trimethylcyclohex-1-en-1- yl-glycine MAA-27 [00065] 2-[(3-(3,4-dimethoxyphenyl)imi- no-2-methyl-cyclohexen-1- yl)amino]acetic acid MAA-28 [00066] 2-[(5,5-dimethyl-3-(4- sulfophenyl)imino-cyclohexen-1- yl)amino]acetic acid MAA-29 [00067] 2-[(3-(4- sulfophenyl)iminocyclohexen-1- yl)amino]acetic acid MAA-30 [00068] 2,5,5-trimethyl-3-((4- sulfophenyl)imino)cyclohex-1-en- 1-yl-glycine MAA-31 [00069] 2-methyl-3-((4- sulfophenyl)imino)cyclohex-1-en- 1-yl-glycine MAA-32 [00070] 2-[(5,5-dimethyl-3-phenylimino- cyclohexen-1-yl)amino]acetamide MAA-33 [00071] 2-[(3-phenyliminocyclohexen-1- yl)amino]acetamide MAA-34 [00072] 2-((2,5,5-trimethyl-3- (phenylimino)cyclohex-1-en-1- yl)amino)acetamide MAA-35 [00073] 2-((2-methyl-3- (phenylimino)cyclohex-1-en-1- yl)amino)acetamide MAA-36 [00074] 2-((3-((3,4- dimethoxyphenyl)imino)-5,5- dimethylcyclohex-1-en-1- yl)amino)acetamide MAA-37 [00075] 2-[(3-(3,4-dimethoxy- phenyl)iminocyclohexen- 1-yl)amino]acetamide MAA-38 [00076] 2-((3-((3,4- dimethoxyphenyl)imino)-2,5,5- trimethylcyclohex-1-en-1- yl)amino)acetamide MAA-39 [00077] 2-((3-((3,4- dimethoxyphenyl)imino)-2- methylcyclohex-1-en-1- yl)amino)acetamide
or a tautomer or a stereoisomer or a salt of the afore-mentioned compounds, or any mixture of the afore-mentioned compounds.

[0815] Among the above specified mycosporine-like amino acid compounds the compounds MAA-1 and MAA-13 are particularly preferred, since they have a pronounced antimicrobial boosting effect. Most preferred are the acid compounds MAA-20, MAA-21, MAA-22, MAA-23, MAA-24, MAA-24, MAA-26, MAA-27, MAA-28, MAA-29, MAA-30, MAA-31, and the amide compounds MAA-32, MAA-33, MAA-34, MAA-35, MAA-36, MAA-37, MAA-38, and MAA-39. Said compound having an acid functionality or an amide functionality are photo-stable and temperature-stable and show stability in pH solution or in different emulsion types and do not degrade. Particularly preferred are the acid compounds MAA-20, MAA-21, MAA-22, MAA-23, MAA-24, MAA-24, MAA-26, MAA-27, MAA-28, MAA-29, MAA-30 and MAA-31 due to their stability and their improved solubility In water.

[0816] Especially, the mycosporine-like amino acid compounds MAA-20, MAA-21, MAA-22, MAA-23, MAA-24, MAA-24, MAA-26, MAA-27, MAA-28, MAA-29, MAA-30 and MAA-31 have a better stability in a broader pH-range compared to their respective ester compounds which hydrolize, and, thus, are not stable in alkaline solutions having a pH higher than 9.

[0817] Due to their better solubility in water, said mycosporine-like amino acid compounds can be incorporated into the water-phase of formulations in higher concentrations, resulting in a better antimicrobial enhancing or boosting effect in food, cosmetic or pharmaceutical preparations or homecare products. The improved solubility in water is particular useful, since usually microbial contamination takes place in the water phase. This is in particular beneficial for the development of the antimicrobial effect of the mycosporine-like amino acid compounds in the water phase.

[0818] Still more preferred according to the first aspect of the present invention, the food, cosmetic or pharmaceutical preparation or homecare product comprises at least one mycosporine-like amino acid compound selected from the group consisting of:

##STR00078##

or a tautomer or a stereoisomer or a salt thereof, or any mixture of the afore-mentioned compounds, wherein alkyl is preferably either methyl or ethyl or propyl or isopropyl or butyl or isobutyl or tert-butyl, most preferred methyl.

[0819] The mycosporine-like amino acid compounds according to the present invention and defined herein are used either as single substance or in a mixture with one, two or more different mycosporine-like amino acid compounds as defined herein.

[0820] Particular preferred are mixtures of two mycosporine-like amino acid compounds according to the present invention and defined herein. Such mixtures show a particular enhanced stabilizing effect, as it is demonstrated by the following examples.

[0821] The food, cosmetic or pharmaceutical composition or homecare product according to the first aspect of the present invention is further characterized in that it does not contain one or more of the following mycosporine-like amino acid compounds:

##STR00079## ##STR00080##

[0822] Various mycosporine-like amino acid compounds (b) as described herein contain one or more chiral centers, and, thus, can exist as racemic mixtures of enantiomers, mixtures of diastereomers or enantiomerically or optically pure compounds. It should also be noted the compounds of the invention include E and Z isomers, or a mixture thereof, and cis and trans isomers or a mixture thereof.

[0823] Accordingly, the chemical structures of the mycosporine-like amino acid compounds according to the general formulae (V) to (X) and their variants and compounds explicitly disclosed herein include all possible enantiomers and diastereomers or stereoisomers thereof.

[0824] In certain embodiments, the mycosporine-like amino acid compounds (b) of the invention are isolated as either the E or Z isomer. In other embodiments, the compounds of the invention are a mixture of the E and Z isomers.

[0825] Alternatively, stereomerically pure compounds are used in the sunscreen product or cosmetic or pharmaceutical preparation according to the present invention. As used herein and unless otherwise indicated, the term stereomerically pure means that one stereoisomer of a compound is substantially free of other stereoisomers of that compound or one geometric isomer (e.g., about a double bond) is substantially free of the other geometric isomer. For example, a stereomerically pure compound of the invention having one chiral center, will be substantially free of the opposite enantiomer of the compound. A stereomerically pure compound of the invention having two chiral centers, or a composition thereof, will be substantially free of other diastereomers of the compound. A stereomerically pure compound of the invention having a double bond capable of E/Z isomerism, or a composition thereof, will be substantially free of one of the E/Z isomers.

[0826] A typical stereomerically pure compound comprises greater than about 80% by weight of one stereoisomer or E/Z isomer of the compound and less than about 20% by weight of other stereoisomers or E/Z isomer of the compound, more preferably greater than about 90% by weight of one stereoisomer or E/Z isomer of the compound and less than about 10% by weight of the other stereoisomers or E/Z isomer of the compound, even more preferably greater than about 95% by weight of one stereoisomer or E/Z isomer of the compound and less than about 5% by weight of the other stereoisomers or E/Z isomer of the compound, and most preferably greater than about 97% by weight of one stereoisomer or E/Z isomer of the compound and less than about 3% by weight of the other stereoisomers or E/Z isomer of the compound.

[0827] As used herein and unless otherwise indicated, the term stereomerically enriched means a compound of the invention, or a composition thereof, that comprises greater than about 60% by weight of one stereoisomer or E/Z isomer of a compound of the invention, preferably greater than about 70% by weight, more preferably greater than about 80% by weight of one stereoisomer or E/Z isomer of a compound of the invention.

[0828] Thus, it should be noted that unless stated otherwise, the term mycosporine-like amino acid compound according to the general formulae (V) to (X) and their variants as well as individual mycosporine-like amino acid compounds specified herein, are to be interpreted as encompassing racemic mixtures of enantiomers, mixtures of diastereomers or enantiomerically or optically pure compounds.

[0829] Due to their amino cyclohexene imine structure and their capability of electron delocalization, the mycosporine-like amino acid compounds according to general formulae (V) to (X) and their variants are in equilibrium with their tautomer structures, in which the hydrogen of the amino group changes its places with the double bond of the cyclohexene ring.

[0830] Tautomerism is defined as each of two or more isomers of a compound which exist together in equilibrium and are readily interchanged by migration of an atom or group within the molecule. Tautomeric pure or enriched systems will readily interchange into the equilibrium state over time.

[0831] The tautomers of the general formula (V) are represented by general formulae (V-tau):

##STR00081##

[0832] The tautomers of the general formula (VI) are represented by general formula (VI-tau):

##STR00082##

[0833] The above principles of tautomerism and redeposition explained on the basis of the mycosporine-like amino acid compounds according to the general formulae (V) and (VI) are likewise applicable with respect to any of the mycosporine-like amino acid compounds defined by the general formulae (VII), (VIII), (IX) and (X) and their variants or with respect to any individual mycosporine-like amino acid compounds specified herein.

[0834] Thus, in the following and throughout the description, the reference to a mycosporine-like amino acid compound represented by any of the general formulae (V) to (X) and their variants or to an individual mycosporine-like amino acid compound specified herein encompasses likewise its tautomer isomer(s).

[0835] The mycosporine-like amino acid compounds according to the general formulae (V) to (X) and their variants as well as individual mycosporine-like amino acid compounds specified herein are used according to the first aspect of the present invention either in neutral, i.e. uncharged form, or in the form of their salts, such as an acid addition salt, with inorganic or organic acids.

[0836] The term salt in the context of the present invention refers to a salt of a compound that possesses the desired effect or pharmacological activity of the parent compound. Such salts include: [0837] (1) acid addition salts formed with inorganic acids, or formed with organic acids, preferably monovalent or polyvalent carboxylic acids; or [0838] (2) salts formed when an acidic proton present in the starting compound is replaced by a metal ion, e.g., an alkali metal ion, an alkaline earth ion, or an aluminium ion; or coordinated with an organic base.

[0839] Among the salts, acid addition salts are again particularly preferred, since the mycosporine-like amino acid compounds according to the general formulae (V) to (X) and their variants or the mycosporine-like amino acid compounds specified herein comprise a protonable N atom.

[0840] The inorganic acids that form acid addition salts with the mycosporine-like amino acid compounds used according to the present invention are preferably selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like. Particularly preferred is the hydrochloride salt or the sulfate salt or the phosphate salt.

[0841] Even more preferred are acid addition salts with organic mono- or polycarboxylic acids. Further preferred are acid addition salts with organic mono- or polycarboxylic acids, wherein the carboxylic acid is selected from saturated or mono- or polyunsaturated C1 to C30 monocarboxylic acids, saturated or mono- or polyunsaturated C3 to 10 di- or tricarboxylic acids. The carboxylic acid may be mono- or poly-substituted with hydroxy groups, preferably -hydroxycarboxylic acids in which the hydroxy group is located on the carbon atom adjacent to the carboxy group. Many representatives occur naturally as so-called fruit acids. Preferred -hydroxycarboxylic acids are malic acid, citric acid, 2-hydroxy-4-methylmercaptobutyric acid, glycolic acid, isocitric acid, mandelic acid, lactic acid, tartronic acid, or tartaric acid.

[0842] The organic acids that form acid addition salts with the mycosporine-like amino acid compounds used according to the present invention are preferably selected from the group consisting of amino acids, acetic acid, trifluoroacetic acid, propionic acid, hexanoic acid, cyclopentane propionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, oxalic acid, succinic acid, malic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethanedisulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, 4-chlorobenzenesulfonic acid, 2-naphthalenesulfonic acid, 4-toluenesulfonic acid, camphorsulfonic acid, 4-methylbicyclo[2.2.2]-oct-2-ene-1-carboxylic acid, glucoheptonic acid, 3-phenylpropionic acid, trimethylacetic acid, tert. butylacetic acid, laurylsulfuric acid, gluconic acid, glutamic acid, hydroxynaphthoic acid, salicylic acid, stearic acid, muconic acid, 4-hydroxybutanoic acid, and the like.

[0843] Suitable anionic counterions are in particular chloride, bromide, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C1- to C4-alkanoic acids, preferably formate, acetate, trifluoroacetate, propionate and butyrate, furthermore lactate, gluconate, and the anions of poly acids such as succinate, oxalate, maleate, fumarate, malate, tartrate and citrate, furthermore sulfonate anions such as besylate (benzenesulfonate), tosylate (p-toluenesulfonate), napsylate (naphthalene-2-sulfonate), mesylate (methanesulfonate), esylate (ethanesulfonate), and ethanedisulfonate. They can be formed by reacting compounds according to the invention that have a basic functionality with an acid of the corresponding anion. Preferred salts of the compounds of formulae (I) to (III) as well as of the individual mycosporine-like amino acid compounds specified herein are chloride salts.

[0844] The metal ions for salt formation that replace an acidic proton present in the starting compound are selected from the group consisting of alkali metal ions, preferably Na+, K+, or Li+, alkaline earth metal ions, preferably Ca++ or Mg++, aluminium+++, and NH4+.

[0845] The coordinating organic base for salt formation is selected from the group consisting of ethanolamine, diethanolamine, triethanolamine, N-methylglucamine, triethylamine, and the like.

[0846] In the following description and claims, and unless stated otherwise, the term mycosporine-like amino acid compound includes both the neutral, uncharged form of the compound/molecule and equally the salt form of the compound.

[0847] The salt form of the mycosporine-like amino acid compounds leads to a lower log Pow and, thus, making the compounds more hydrophilic, which results in a better water solubility. In particular, the cationic salts of the mycosporine-like amino acid compounds support emulsification processes in emulsions, due to their surface reducing activity, i.e. co-emulsifying, properties. In addition, the cationic salt form of the mycosporine-like compounds shows excellent substantivity behaviour on skin and hair and other non-biological surfaces: most conditioning actives are cationic; the conditioning effect leads to a softer skin feel, which makes the end products more accepted by the consumer. In addition, the mycosporine-like amino acid compounds in the cationic salt form exhibit antimicrobial activity.

[0848] In a preferred advantageously variant, the composition according to the first aspect of the present invention comprises one of the following combinations of components (a) and (b): [0849] one or more of the following antimicrobial components: Caprylhydroxamic Acid, and/or o-Cymen-5-ol, and/or Isopropylparaben, and/or Capryloyl Glycine, and/or Phenylpropanol, and/or Tropolone, and/or PCA Ethyl Cocoyl Arginate, and/or 2-Methyl 5-Cyclohexylpentanol, and/or Phenoxyethanol, and/or Disodium EDTA, and/or Cetrimonium Chloride, and/or Methylparaben and its salts, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Sodium Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Dehydroacetic Acid, and/or Salicylic Acid, and/or Chlorphenesin, and/or Isobutylparaben, and/or Sodium Ethylparaben, and/or Diazolidinyl Urea, and/or Diazolidinyl Urea, and/or Farnesol, and/or Bisabolol, and/or Formic acid and its salts, and/or Glyceryl Caprylate, and/or Sodium Phytate or Phytic Acid, and/or Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, and/or Chlorhexidine, and/or Glyceryl Laurate, and/or Anisic Acid and its salts, and/or Chlorhexidine Digluconate, and/or TEA-salicylate, and/or Phenethyl Alcohol, and/or Glyceryl Caprate, and/or Sorbitan Caprylate, and/or Tetrasodium Glutamate Diacetate, and/or Trisodium Ethylenediamine Disuccinate, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or Undecylenoyl Glycine, and/or Thymol, and/or 4-Hydroxyacetophenone, and/or Lactic Acid, and/or Sodium Lactate, and/or Trisodium Dicarboxymethyl Alaninate, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, and/or Benzoesure-3-hydroxypropylester, combined with a mycosporine-like amino acid compound of the general formula (V); or [0850] one or more of the following antimicrobial components: Caprylhydroxamic Acid, and/or o-Cymen-5-ol, and/or Isopropylparaben, and/or Capryloyl Glycine, and/or Phenylpropanol, and/or Tropolone, and/or PCA Ethyl Cocoyl Arginate, and/or 2-Methyl 5-Cyclohexylpentanol, and/or Phenoxyethanol, and/or Disodium EDTA, and/or Cetrimonium Chloride, and/or Methylparaben and its salts, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Sodium Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Dehydroacetic Acid, and/or Salicylic Acid, and/or Chlorphenesin, and/or Isobutylparaben, and/or Sodium Ethylparaben, and/or Diazolidinyl Urea, and/or Diazolidinyl Urea, and/or Farnesol, and/or Bisabolol, and/or Formic acid and its salts, and/or Glyceryl Caprylate, and/or Sodium Phytate or Phytic Acid, and/or Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, and/or Chlorhexidine, and/or Glyceryl Laurate, and/or Anisic Acid and its salts, and/or Chlorhexidine Digluconate, and/or TEA-salicylate, and/or Phenethyl Alcohol, and/or Glyceryl Caprate, and/or Sorbitan Caprylate, and/or Tetrasodium Glutamate Diacetate, and/or Trisodium Ethylenediamine Disuccinate, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or Undecylenoyl Glycine, and/or Thymol, and/or 4-Hydroxyacetophenone, and/or Lactic Acid, and/or Sodium Lactate, and/or Trisodium Dicarboxymethyl Alaninate, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, and/or Benzoesure-3-hydroxypropylester, combined with a mycosporine-like amino acid compound of the general formula (VI).

[0851] More preferred combinations of components (a) and (b) in the composition according to the first aspect of the present invention are: [0852] one or more of the following antimicrobial components: Caprylhydroxamic Acid, and/or o-Cymen-5-ol, and/or Isopropylparaben, and/or Capryloyl Glycine, and/or Phenylpropanol, and/or Tropolone, and/or PCA Ethyl Cocoyl Arginate, and/or 2-Methyl 5-Cyclohexylpentanol, and/or Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben and its salts, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Sodium Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Dehydroacetic Acid, and/or Salicylic Acid, and/or Chlorphenesin, and/or Isobutylparaben, and/or Sodium Ethylparaben, and/or Diazolidinyl Urea, and/or Diazolidinyl Urea, and/or Farnesol, and/or Glyceryl Caprylate, and/or Sodium Phytate or Phytic Acid, and/or Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, and/or Chlorhexidine, and/or Glyceryl Laurate, and/or Anisic Acid and its salts, and/or Chlorhexidine Digluconate, and/or TEA-salicylate, and/or Phenethyl Alcohol, and/or Glyceryl Caprate, and/or Sorbitan Caprylate, and/or Tetrasodium Glutamate Diacetate, and/or Trisodium Ethylenediamine Disuccinate, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or Undecylenoyl Glycine, and/or Thymol, and/or 4-Hydroxyacetophenone, and/or Lactic Acid, and/or Sodium Lactate, and/or Trisodium Dicarboxymethyl Alaninate, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with a mycosporine-like amino acid compound of the general formula (V); or [0853] one or more of the following antimicrobial components: Caprylhydroxamic Acid, and/or o-Cymen-5-ol, and/or Isopropylparaben, and/or Capryloyl Glycine, and/or Phenylpropanol, and/or Tropolone, and/or PCA Ethyl Cocoyl Arginate, and/or 2-Methyl 5-Cyclohexylpentanol, and/or Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben and its salts, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Sodium Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Dehydroacetic Acid, and/or Salicylic Acid, and/or Chlorphenesin, and/or Isobutylparaben, and/or Sodium Ethylparaben, and/or Diazolidinyl Urea, and/or Diazolidinyl Urea, and/or Farnesol, and/or Glyceryl Caprylate, and/or Sodium Phytate or Phytic Acid, and/or Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, and/or Chlorhexidine, and/or Glyceryl Laurate, and/or Anisic Acid and its salts, and/or Chlorhexidine Digluconate, and/or TEA-salicylate, and/or Phenethyl Alcohol, and/or Glyceryl Caprate, and/or Sorbitan Caprylate, and/or Tetrasodium Glutamate Diacetate, and/or Trisodium Ethylenediamine Disuccinate, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or Undecylenoyl Glycine, and/or Thymol, and/or 4-Hydroxyacetophenone, and/or Lactic Acid, and/or Sodium Lactate, and/or Trisodium Dicarboxymethyl Alaninate, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with a mycosporine-like amino acid compound of the general formula (VI).

[0854] In a still more preferred variant, the composition according to the first aspect of the present invention comprises one of the following combinations of components (a) and (b): [0855] one or more of the following antimicrobial components: Dehydroacetic Acid, and/or Iodopropynyl Butylcarbamate, and/or Salicylic Acid, and/or Chlorphenesin, and/or Isobutylparaben, and/or Sodium Ethylparaben, and/or Diazolidinyl Urea, and/or Diazolidinyl Urea, and/or Farnesol, and/or Bisabolol, and/or Glyceryl Caprylate, and/or Sodium Phytate or Phytic Acid, and/or Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, and/or Chlorhexidine, and/or Glyceryl Laurate, and/or Anisic Acid and its salts, and/or Chlorhexidine Digluconate, and/or TEA-Salicylate, and/or Phenethyl Alcohol, and/or Glyceryl Caprate, and/or Sorbitan Caprylate, and/or Tetrasodium Glutamate Diacetate, and/or Trisodium Ethylenediamine Disuccinate, and/or Sodium Lactate, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with a mycosporine-like amino acid compound of the general formula (V); or [0856] one or more of the following antimicrobial components: Dehydroacetic Acid, and/or Iodopropynyl Butylcarbamate, and/or Salicylic Acid, and/or Chlorphenesin, and/or Isobutylparaben, and/or Sodium Ethylparaben, and/or Diazolidinyl Urea, and/or Diazolidinyl Urea, and/or Farnesol, and/or Bisabolol, and/or Glyceryl Caprylate, and/or Sodium Phytate or Phytic Acid, and/or Sodium Levulinate or Levulinic Acid and esters and/or ketals thereof, and/or Chlorhexidine, and/or Glyceryl Laurate, and/or Anisic Acid and its salts, and/or Chlorhexidine Digluconate, and/or TEA-Salicylate, and/or Phenethyl Alcohol, and/or Glyceryl Caprate, and/or Sorbitan Caprylate, and/or Tetrasodium Glutamate Diacetate, and/or Trisodium Ethylenediamine Disuccinate, and/or Sodium Lactate, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with a mycosporine-like amino acid compound of the general formula (VI).

[0857] In a most preferred variant, the composition according to the first aspect of the present invention comprises one of the following combinations of components (a) and (b): [0858] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with a mycosporine-like amino acid compound of the general formula (V); or [0859] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with a mycosporine-like amino acid compound of the general formula (VI).

[0860] The above mycosporine-like amino acid/antimicrobial combinations result in superior synergistic antimicrobial efficacy. This effect is demonstrated by the MIC-test in the following examples.

[0861] In a particular preferred variant, the food, cosmetic or pharmaceutical preparation or homecare product according to the first aspect of the present invention comprises one of the following mixtures/combinations of a mycosporine-like amino acid compound (a) and an antimicrobial compound (b): [0862] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-1 as depicted in Table 3; or [0863] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-2 as depicted in Table 3; [0864] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-3 as depicted in Table 3; or [0865] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-4 as depicted in Table 3; or [0866] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, r 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-5 as depicted in Table 3; or [0867] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-6 as depicted in Table 3; or [0868] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-7 as depicted in Table 3; or [0869] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-8 as depicted in Table 3; or [0870] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-9 as depicted in Table 3; or [0871] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, r 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-11 as depicted in Table 3; or [0872] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-12 as depicted in Table 3; or [0873] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-13 as depicted in Table 3; or [0874] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-14 as depicted in Table 3; or [0875] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-16 as depicted in Table 3; or [0876] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, r 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-17 as depicted in Table 3; or [0877] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-20 as depicted in Table 3; or [0878] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-21 as depicted in Table 3; or [0879] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-22 as depicted in Table 3; or [0880] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-23 as depicted in Table 3; or [0881] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, r 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-24 as depicted in Table 3; or [0882] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-25 as depicted in Table 3; or [0883] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-26 as depicted in Table 3; or [0884] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-27 as depicted in Table 3; or [0885] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-28 as depicted in Table 3; or [0886] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, r 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-29 as depicted in Table 3; or [0887] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-30 as depicted in Table 3; or [0888] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-31 as depicted in Table 3; or [0889] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-32 as depicted in Table 3; or [0890] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-33 as depicted in Table 3; or [0891] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, r 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-34 as depicted in Table 3; or [0892] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-35 as depicted in Table 3; or [0893] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-36 as depicted in Table 3; or [0894] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-37 as depicted in Table 3; or [0895] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, and/or 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-38 as depicted in Table 3; or [0896] one or more of the following antimicrobial components: Phenoxyethanol, and/or Disodium EDTA, and/or Methylparaben, and/or Sodium Benzoate, and/or Benzyl Alcohol, and/or Potassium Sorbate, and/or Benzyl Salicylate, and/or Propylparaben, and/or Methylparaben, and/or Methylchloroisothiazolinone, and/or Methylisothiazolinone, and/or Ethylhexylglycerin, and/or Butylparaben, and/or Ethylparaben, and/or Sodium Propylparaben, and/or DMDM Hydantoin, and/or Hydroxyethoxyphenyl Butanone, and/or Hydroxyethoxyphenyl Butanol, and/or Itaconic Acid, and/or Octopirox, and/or Propanediol Caprylate, and/or Climbazole, and/or 4-Hydroxyacetophenone, and/or Frambinon, and/or Xylityl caprylate, and/or Benzoic acid 3-hyroxypropylester, and/or Anisic acid 3-hydroxypropylester, and/or 3-Hydroxypropyl 2-hydroxybenzoate, and/or 1,3-propanediol, and/or 1,2-pentanediol, and/or 1,2-hexanediol, and/or 1,2-heptanediol, and/or 1,2-octanediol, and/or 1,2-nonanediol, and/or 1,2-decanediol, and/or 1,2-undecanediol, and/or 1,2-dodecanediol, and/or 2,3-pentanediol, and/or 2,3-hexanediol, and/or 2,3-heptanediol, and/or 2,3-octanediol, and/or 2,3-nonanediol, r 2,3-decanediol, and/or 2,3-undecanediol, and/or 2,3-dodecanediol, combined with compound MAA-39 as depicted in Table 3.

[0897] Most preferred combinations are the above specified antimicrobial compounds with MAA-1, MAA-13 or one of the compounds MAA-20 to MAA-39.

[0898] The above combinations exhibit a synergistic antimicrobial effect against a broad spectrum of microorganism, i.e. against bacteria, yeast and fungi/mould as it is discussed below in more detail and demonstrated in the following examples. Surprisingly, the synergistic antimicrobial effect could also demonstrated for Candida, such as Candida albicans and Aspergillus, such as Aspergillus brasiliensis, which both are known to be combated only with great difficulty.

[0899] In order to further enhance antimicrobial efficacy, the food, cosmetic or pharmaceutical preparation or homecare product according to the present invention, is advantageously combined with at least one further antimicrobial agent which is different from the antimicrobial compound (a) of the composition according to the present invention. The combination with a further antimicrobial agent provides reliable protection against microbial degradation and deterioration of the preparation, in particular during storage. Additionally, the further different antimicrobial agent provides reliable protection against other microorganisms as described above, for example Corynebacterium, Anaerococcus, Finegoldia, Moraxella, Porphyromonas, Fusobacterium, Malassezia, Peptoniphilus, Streptococcus, Lactobacillus, Gardnerella, Fannyhessea, Epidermophyton, Trichophyton, Cutibacterium. Hence, the combination with a further different antimicrobial agent allows antimicrobial protection against different groups of microorganisms, and, thus, a broader spectrum of microorganism. Furthermore, with the further different antimicrobial agent the composition according to the present invention can also be provided with a different antimicrobial target, preferably antimicrobials for skin protection.

[0900] The further different antimicrobial agent in the context of the present invention is preferably selected from the group consisting of 2-benzylheptanol, alkyl (C 12-22) trimethyl ammonium bromide and chloride, ascorbic acid and salts thereof, benzalkonium bromide, benzalkonium chloride, benzalkonium saccharinate, benzethonium chloride, Benzoic Acid, camphor, cetylpyridinium chloride, chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorocresol, chloroxylenol, Cyclohexylglycerin, Chlorobutanol, Carvacrol, Dimethyl phenylbutanol, Dimethyl phenylpropanol, ethanol, ethyl lauroyl arginate HCl, Ethyl Lauroyl Arginate Laurate, eucalyptol, gluconic acid and salts thereof, glycerin, hexamidine, hexamidine diisethionate, Hexylglycerin, Iodopropynyl Butylcarbamate, jasmol, lauryl alcohol, Levulinic Acid and esters and/or ketals thereof, mannitol, menthol, methyl salicylate, Octenidine HCl, polyarginine, Polyglyceryl-10 Laurate, polyglyceryl-2 caprate, Polyglyceryl-3 caprylate, polylysine, Salvia Officinalis (Sage) Oil, silver chloride, silver citrate, sodium caproyl lactylate, Sodium Caproyl/Lauroyl Lactylate, sodium lauroyl lactylate, Sorbic Acid, sorbitol, Tetraselmis extract, triclocarban, triclosan, Triethyl citrate, Xylityl Sesquicaprylate, zinc citrate, zinc pyrithione, Zinc ricinoleate, and mixtures of two or more of the aforesaid antimicrobial agents.

[0901] In a more preferred variant, the further different antimicrobial agent is selected from the group consisting of 2-benzylheptanol, Benzoic Acid, Dimethyl phenylbutanol, Dimethyl phenylpropanol, ethyl lauroyl arginate HCl, Ethyl Lauroyl Arginate Laurate, gluconic acid and salts thereof, Glyceryl laurate, jasmol, lauryl alcohol, Levulinic Acid and esters and/or ketals thereof, Mannitol, Octenidine HCl, Polyglyceryl-10 Laurate, polyglyceryl-2 caprate, Polyglyceryl-3 caprylate, Salvia Officinalis (Sage) Oil, sodium caproyl lactylate, Sodium Caproyl/Lauroyl Lactylate, sodium lauroyl lactylate, Sorbic Acid, sorbitol, Tetraselmis extract, Triclosan, Triethyl citrate, Xylityl Sesquicaprylate, Zinc ricinoleate, and mixtures of two or more of the aforesaid antimicrobial agents.

[0902] The at least one antimicrobial compound (a) is present in the food, cosmetic or pharmaceutical preparation or homecare product in an amount of 0.0001 to 10.0% by weight, based on the total weight of the food, cosmetic or pharmaceutical preparation or homecare product. In a preferred variant, the food, cosmetic or pharmaceutical preparation or homecare product comprises the antimicrobial component in an amount of 0.0005 to 8.0% by weight, based on the total weight of the food, cosmetic or pharmaceutical preparation or homecare product. In a most preferred variant, the antimicrobial component is advantageously used in the food, cosmetic or pharmaceutical preparation or homecare product in an amount of at 0.001 to 6.0% by weight, based on the total weight of the composition or final food, cosmetic or pharmaceutical preparation or homecare product.

[0903] For a mixture of antimicrobials, the above amounts relate to the total content of the antimicrobials in the mixture, i.e. the amount is the sum of the content of all antimicrobials in the mixture.

[0904] The at least one mycosporine-like amino acid compound (b) is present in the food, cosmetic or pharmaceutical preparation or homecare product in an amount of 0.001 to 15.0% by weight, based on the total weight of the final formulation. In a preferred variant, the sunscreen product or cosmetic or pharmaceutical preparation comprises the at least one mycosporine-like amino acid compound (b) in an amount of 0.01 to 10.0% by weight, based on the total weight of the final formulation. In a more preferred variant, the at least one mycosporine-like amino acid compound (b) is advantageously used in the sunscreen product or cosmetic or pharmaceutical preparation in an amount of at 0.05 to 7.5% by weight, based on the total weight of the final formulation. In a most preferred variant, the at least one mycosporine-like amino acid compound is advantageously used in the sunscreen product or cosmetic or pharmaceutical preparation in an amount of at 0.1 to 5.0% by weight, based on the total weight of the final formulation.

[0905] For a mixture of mycosporine-like amino acid compounds (b), the above amounts relate to the total content of the mycosporine-like amino acid compounds in the mixture, i.e. the amount is the sum of the content of all mycosporine-like amino acid compounds (b) in the mixture.

[0906] Within the context of the present invention, it is also possible and in some cases advantageous to combine the food, cosmetic or pharmaceutical preparation or homecare product according to the first aspect of the present invention with other customary active substances, adjuvants or additives, customarily used for food, cosmetic or pharmaceutical compositions or homecare products, as further described below, in order to obtain a ready-for-use preparation or formulation.

[0907] The other active agents and/or adjuvants and/or additives or auxiliaries are for example abrasives, anti-acne agents, agents against ageing of the skin, anti-cellulitis agents, anti-dandruff agents, anti-inflammatory agents, irritation-preventing agents, irritation-inhibiting agents, antioxidants, alkanediols, astringents, odour absorbers, perspiration-inhibiting agents, antiseptic agents, anti-statics, antimicrobial agents, binders, buffers, carrier materials, oil components, chelating agents, cell stimulants, cleansing agents, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, softeners, emulsifiers, enzymes, enzyme inhibitors, essential oils, fibres, film-forming agents, water resistance improving agents fixatives, foam-forming agents, foam stabilizers, substances for preventing foaming, foam boosters, gelling agents, gel-forming agents, hair care agents, hair-setting agents, hair-straightening agents, moisture-donating agents, moisturizing substances, moisture-retaining substances, bleaching agents, strengthening agents, stain-removing agents, optically brightening agents, impregnating agents, dirt-repellent agents, dyes, friction-reducing agents, lubricants, moisturizing creams, ointments, opacifying agents, plasticizing agents, covering agents, polish, preservatives, gloss agents, green and synthetic polymers, powders, proteins, re-oiling agents, abrading agents, silicones, skin-soothing agents, skin-cleansing agents, skin care agents, skin-healing agents, skin-lightening agents, skin-protecting agents, skin-softening agents, hair promotion agents, cooling agents, skin-cooling agents, warming agents, skin-warming agents, stabilizers, surfactants, antimicrobial agents, detergents/surfactants, fabric conditioning agents, suspending agents, skin-tanning agents, actives modulating skin or hair pigmentation, matrix-metalloproteinase inhibitors, skin moisturizing agents, glycosaminoglycan stimulators, TRPV1 antagonists, desquamating agents, anti-cellulite agents or fat enhancing agents, hair growth activators or inhibitors, thickeners, rheology additives, vitamins, oils, waxes, pearlizing waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, -hydroxy acids, polyhydroxy fatty acids, liquefiers, dyestuffs, colour-protecting agents, pigments, anti-corrosives, fragrances or perfume oils, aromas, flavouring substances, odoriferous substances, polyols, electrolytes, organic solvents, and mixtures of two or more of the aforementioned substances, as further described below.

[0908] Of the above cosmetically or pharmaceutically excipients and/or active substances and/or additives and/or auxiliaries carriers, oil components, rheology additives, hydrotropes, solubilizing agents, powders, film formers, water resistance improving agents, skin moisturizing and/or moisture-retaining substances, lenitive substances, physiological cooling agents, alkanediols, antioxidants, agents against ageing of the skin, matrix-metalloproteinase inhibitors (MMPI), anti-inflammatory agents, TRPV1 antagonists, emulsifiers, antimicrobial agents, preservatives, antibacterial or antimycotic active substances, chelating agents, surfactants, fragrances/aroma or perfume oils, and any mixture of two or more of the afore-mentioned substances are particularly preferred in the preparation of sunscreen products, cosmetic and pharmaceutical preparations or homecare products.

[0909] Carriers: The sunscreen products, cosmetic or pharmaceutical, in particular dermatological, preparations or homecare products as defined herein, in the form of ointments, pastes, creams and gels, etc., are preferably based on a carrier. Most common acceptable carrier is water. Acceptable carriers other than water include glycerin, C1-4 alcohols, organic solvents, fatty alcohols, fatty ethers, fatty esters, polyols, glycols, vegetable oils, mineral oils, liposomes, laminar lipid materials, water, or a mixture thereof. Non-limiting examples of organic solvents include mono alcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, benzyl alcohol, and phenylethyl alcohol, or glycols or glycol ethers such as, for example, monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof such as, for example, monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, for example monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propane diol, and glycerin. The organic solvents can be volatile or non-volatile compounds. The total amount of carrier in the compositions can vary but is typically 40 to 90% by weight, based on the total weight of the composition.

[0910] The compositions of the present invention may include at least one water-soluble or organic solvent. Non-limiting examples of organic solvents include monoalcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, benzyl alcohol, and phenylethyl alcohol, or glycols or glycol ethers such as, for example, monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof such as, for example, monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, for example monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propane diol, and glycerin. The organic solvents can be volatile or non-volatile compounds.

[0911] Further non-limiting examples of water-soluble solvents include alkanols (polyhydric alcohols such as glycols and polyols) such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, diethylene glycol, butylene glycol, hexylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, and 4-methyl-1,2-pentanediol; alkyl alcohols having 1 to 4 carbon atoms such as ethanol, methanol, butanol, propanol, and isopropanol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol mono-iso-propyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1-methyl-1-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-iso-propyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, and dipropylene glycol mono-iso-propyl ether; 2-pyrrolidone, N-methyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolidinone, formamide, acetamide, dimethyl sulfoxide, sorbit, sorbitan, acetine, diacetine, triacetine, sulfolane, and any mixture thereof. The total amount water-soluble or organic solvent(s) in the composition according to the present invention may vary but is typically 0.1 to 50% by weight, based on the total weight of the composition.

[0912] In addition, hydrotropes, for example ethanol, isopropyl alcohol or polyols, may be used to improve flow behaviour. Suitable polyols preferably contain 2 to 15 carbon atoms and at least two hydroxyl groups. The polyols may contain other functional groups, more especially amino groups, or may be modified with nitrogen. Typical examples are [0913] glycerol; [0914] alkylene glycols such as, for example, ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols with an average molecular weight of 100 to 1000 Dalton; [0915] technical oligoglycerol mixtures with a degree of self-condensation of 1.5 to 10, such as for example technical diglycerol mixtures with a diglycerol content of 40 to 50% by weight; [0916] methylol compounds such as, in particular, trimethylol ethane, trimethylol propane, trimethylol butane, pentaerythritol and dipentaerythritol; [0917] lower alkyl glucosides, particularly those containing 1 to 8 carbon atoms in the alkyl group, for example methyl and butyl glucoside; [0918] sugar alcohols containing 5 to 12 carbon atoms, for example sorbitol or mannitol, [0919] sugars containing 5 to 12 carbon atoms, for example glucose or sucrose; [0920] amino sugars, for example glucamine; and [0921] dialcoholamines, such as diethanolamine or 2-aminopropane-1,3-diol.

[0922] Solubilizing agents: The compositions of the present invention may include at least one solubilizing agent. Solubilizing agents are compounds that help solubilize the UV-filter(s) and/or other components in the compositions. A particularly useful but non limiting example of a solubilizing agent is a hydrotrope. Hydrotropes (or hydrotropic agents) are a diverse class of typically water-soluble compounds that may be characterized by an amphiphilic molecular structure and an ability to dramatically increase the solubility of poorly soluble organic molecules in water. Non-limiting examples of hydrotopes include sodium 1,3-benzenedisulfonate, sodium benzoate, sodium 4-pyridinecarboxylate, sodium salicylate, sodium benzene sulfonate, caffeine, sodium p-toluene sulfonate, sodium butyl monoglycolsulfate, 4-aminobenzoic acid HCl, sodium cumene sulfonate, N, N-diethylnicotinamide, N-picolylnicotinamide, N-allylnicotinamide, 2-methacryloyloxyethyl phosphorylcholine, resorcinol, butylurea, pyrogallol, N-picolylacetamide 3.5, procaine HCl, proline HCl, nicotinamide, pyridine, 3-picolylamine, sodium ibuprofen, sodium xylenesulfonate, ethyl carbamate, pyridoxal hydrochloride, sodium benzoate, 2-pyrrolidone, ethylurea, N,N-dimethylacetamide, N-methylacetamide, and isoniazid and any mixture thereof. In some cases, particularly useful hydrotropes include nicotinamide (niacinamide), caffeine, sodium PCA, sodium salicylate, urea, and dhydroxyethyl urea, in particular, nicotinamide (niacinamide) and/or caffeine. A combination of two or more, three or more, or four or more hydrotopes may also be used in the compositions according to the present invention. The total amount of solubilizing agent(s) in the compositions of the present invention may vary but are typically in an amount of 0.01 to 20% by weight, based on the total weight of the composition.

[0923] Oil components: The sunscreen product or cosmetic or pharmaceutical preparation may include at least one oil phase or at least one oil component, waxes, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silica, talc and zinc oxide or any mixture thereof. Powders include carriers such as lactose, talc, silica, aluminium hydroxide, calcium silicate and polyamide powder or any mixture thereof. Solutions and emulsions include carriers such as solvents such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, propylene glycol, etc. or any mixture thereof. However, preparations solely based on water are also possible. Oils, oil-in-water and water-in-oil emulsions, etc. are preferred.

[0924] The oil phase or the oil component in the sunscreen product, cosmetic or pharmaceutical preparation or homecare product according to the present invention which may be suitable are for example plant oils, hydrocarbons, fatty alcohols, fatty acid esters, or mixtures of two or more of the aforesaid oil components.

[0925] The oil phase or oil component in the cosmetic or pharmaceutical preparation is preferably a plant oil and even more preferably a liquid plant oil. It can also advantageously be a mixture of two or more plant oils components, especially liquid plant oil mixtures.

[0926] Plant oils or vegetable oils are oils extracted from seeds, or less often, from other parts of fruits. Like animal fats, plant oils are mixtures of triglycerides. Soybean oil, rapeseed oil and cocoa butter are examples of plant oils from seeds. Olive oil, palm oil and rice bran oil are examples of oils from other parts of fruits. In common usage, plant oil or vegetable oil may refer exclusively to vegetable fats which are liquid at room temperature or at 35 to 37 C. skin temperature. Vegetable oils are usually edible.

[0927] The term plant oils also includes unsaturated plant oils. Unsaturated oils or vegetable oils can be transformed through partial or complete hydrogenation into oils of higher melting point. The hydrogenation process involves sparging the oil at high temperature and pressure with hydrogen in the presence of a catalyst, typically a powdered nickel compound. As each carbon-carbon double-bond is chemically reduced to a single bond, two hydrogen atoms each form single bonds with the two carbon atoms. The elimination of double bonds by adding hydrogen atoms is called saturation; as the degree of saturation increases, the oil progresses toward being fully hydrogenated. An oil may be hydrogenated to increase resistance to rancidity (oxidation) or to change its physical characteristics. As the degree of saturation increases, the oil's viscosity and melting point increase.

[0928] In a preferred variant, the plant oil is selected from the group consisting of Persea Gratissima (Avocado Oil), Abies Alba Seed Oil, Acacia Victoriae Seed Oil, Actinidia Chinensis (Kiwi) Seed Oil, Amaranthus Hypochondriacus Seed Oil, Arachis Hypogaea (Peanut) Oil, Astrocaryum Murumuru Seed Butter, Astrocaryum Tucuma Seed Butter, Astrocaryum Tucuma Seed Oil, Astrocaryum Vulgare Fruit Oil, Astrocaryum Vulgare Kernel Oil, Avena Sativa (Oat) Kernel Oil, Brassica Alba Seed Oil, Brassica Campestris (Rapeseed) Seed Oil, Butyrospermum Parkii (Shea) Butter, Butyrospermum Parkii (Shea) Oil, Calendula Officinalis Seed Oil, Calophyllum Inophyllum Seed Oil, Calophyllum Tacamahaca Seed Oil, Camellia Oleifera Seed Oil, Camellia Reticulata Seed Oil, Camellia Sinensis Seed Oil, Cannabis Sativa Seed Oil, Cannabis Sativa Seed/Stem Oil, Canola Oil, Carthamus Tinctorius (Safflower) Seed Oil, Chlorella Vulgaris Oil, Citrullus Lanatus (Watermelon) Seed Oil, Citrus Aurantifolia (Lime) Seed Oil, Citrus Aurantium Dulcis (Orange) Seed Oil, Citrus Grandis (Grapefruit) Seed Oil, Cocos Nucifera (Coconut) Oil, Cocos Nucifera (Coconut) Seed Butter, Coffea Arabica (Coffee) Seed Oil, Chlorella Oil (biotech), Corylus Americana (Hazelnut) Seed Oil, Corylus Avellana (Hazelnut) Seed Oil, Cucumis Melo (Melon) Seed Oil, Cucumis Sativus (Cucumber) Seed Oil, Cucurbita Pepo (Pumpkin) Seed Oil, Elaeis Guineensis (Palm) Oil, Elaeis (Palm) Fruit Oil, Glycine Soja (Soybean) Oil, GosSY-pium Herbaceum (Cotton) Seed Oil, GosSY-pium Hirsutum (Cotton) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Macadamia Integrifolia Seed Oil, Macadamia Ternifolia Seed Oil, Mangifera Indica (Mango) Seed Butter, Mangifera Indica (Mango) Seed Oil, Melissa Officinalis Seed Oil, Microalgae Oil, Moringa Oleifera Seed Oil, Moringa Peregrina Seed Oil, Oenothera Biennis (Evening Primrose) Oil, Olea Europaea (Olive) Fruit Oil, Olus Oil, Orbignya Oleifera Seed Oil, Orbignya Speciosa Kernel Oil, Oryza Sativa (Rice) Bran/Germ Oil, Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Oryza Sativa (Rice) Lipids, Oryza Sativa (Rice) Seed Oil, Papaver Somniferum Seed Oil, Passiflora Edulis Seed Oil, Persea Gratissima (Avocado) Butter, Persea Gratissima (Avocado) Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Prunus Armeniaca (Apricot) Kernel Oil, Prunus Persica (Peach) Kernel Oil, Punica Granatum Seed Oil, Pyrus Malus (Apple) Seed Oil, Ricinoleic/Caproic/Caprylic/Capric Triglyceride(s), Ricinus Communis (Castor) Seed Oil, Rosa Canina Fruit Oil, Rosa Moschata Seed Oil, Rubus Idaeus (Raspberry) Seed Oil, Sesamum Indicum (Sesame) Seed Butter, Soybean Glycerides, Theobroma Cacao (Cocoa) Seed Butter, Theobroma Grandiflorum Seed Butter, Triticum Vulgare (Wheat) Bran Lipids, Triticum Vulgare (Wheat) Germ Oil, Vitis Vinifera (Grape) Seed Oil, Zea Mays (Corn) Germ Oil, and Zea Mays (Corn) Oil.

[0929] The above specified plant oils are the most common natural lipid components used as basic substances for the manufacture of cosmetics or pharmaceutical formulations.

[0930] Hydrocarbons (mineral oils) are in general organic compounds consisting entirely of hydrogen and carbon. As defined by IUPAC nomenclature or organic chemistry, the classifications for hydrocarbons are: [0931] 1. Saturated hydrocarbons are the simplest of the hydrocarbon species. They are composed entirely of single bonds and are saturated with hydrogen. The formula for acyclic saturated hydrocarbons (i.e., alkanes) is C.sub.nH.sub.2n+2. The most general form of saturated hydrocarbons is C.sub.nH.sub.2n+2(1r), where r is the number of rings. Those with exactly one ring are the cycloalkanes. Saturated hydrocarbons are the basis of petroleum fuels and are found as either linear or branched species. [0932] 2. Unsaturated hydrocarbons have one or more double or triple bonds between carbon atoms. Those with double bond are called alkenes. Those with one double bond have the formula C.sub.nH.sub.2n (assuming non-cyclic structures). Those containing triple bonds are called alkynes. Those with one triple bond have the formula C.sub.nH.sub.2n2. [0933] 3. Aromatic hydrocarbons, also known as arenes, are hydrocarbons that have at least one aromatic ring.

[0934] Hydrocarbons can be inter alia liquids (e.g. hexane and benzene), waxes or low melting solids (e.g. paraffin wax and naphthalene). The term aliphatic refers to non-aromatic hydrocarbons. Saturated aliphatic hydrocarbons are sometimes referred to as paraffins. Mineral oils and waxes are mixtures of predominantly saturated hydrocarbons consisting of straight-chain, branched and ring structures with carbon chain lengths greater than C14. Mineral oils and waxes are chemical substances prepared from naturally occurring crude petroleum oil. They mainly consist of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). Hydrocarbons have been used for many decades in skin and lip care cosmetic products due to their excellent skin tolerance as well as their high protecting and cleansing performance and broad viscosity options. In contrast to vegetable oils, mineral oils are non-allergenic since they are highly stable and not susceptible to oxidation or rancidity.

[0935] A fatty alcohol (or long-chain alcohol) is usually a high-molecular-weight, straight-chain primary alcohol, but can also range from as few as 4 to 6 carbons to as many as 22 to 26, derived from natural fats and oils. The precise chain length varies with the source. Some commercially important fatty alcohols are lauryl, stearyl and oleyl alcohols. They are colourless oily liquids (for smaller carbon numbers) or waxy solids, although impure samples may appear yellow. Fatty alcohols usually have an even number of carbon atoms and a single alcohol group (OH) attached to the terminal carbon. Some are unsaturated and some are branched. Most fatty alcohols in nature are found as waxes which are esters with fatty acids and fatty alcohols. The traditional sources of fatty alcohols have largely been various vegetable oils and these remain a large-scale feedstock. The alcohols are obtained from the triglycerides (fatty acid triesters), which form the bulk of the oil. The process involves the transesterification of the triglycerides to give methyl esters which are then hydrogenated to give the fatty alcohols. Fatty alcohols are also prepared from petrochemical sources. In the Ziegler process, ethylene is oligomerized using triethylaluminium followed by air oxidation. Alternatively, ethylene can be oligomerized to give mixtures of alkenes, which are subjected to hydroformylation, this process affording odd-numbered aldehyde, which is subsequently hydrogenated. Fatty alcohols are mainly used in the production of detergents and surfactants. They are components also of cosmetic solvents. They find use as co-emulsifiers, emollients and thickeners in cosmetics.

[0936] In a preferred variant, the fatty alcohol is selected from the group consisting of phenyl propanol, dimethyl phenylbutanol, hexyldecanol, octyldodecanol, octyldecanol, tridecylalcohol, isostearyl alcohol, phenylisohexanol, phenylpropanol, trimethylbenzenepropanol, isoamylalcohol, isostearyl alcohol, and isotridecyl alcohol. In a more preferred variant, the fatty alcohol is selected from the group consisting of hexyldecanol, octyldodecanol, phenylpropanol, isoamylalcohol, and mixtures of two or more of the aforesaid fatty alcohols. The fatty alcohol can be used either as a single component or in a mixture with one or more further different fatty alcohol(s) as specified above.

[0937] A fatty acid ester is a type of ester that results from the combination of a fatty acid with an alcohol. When the alcohol component is glycerol, the fatty acid esters produced can be monoglycerides, diglycerides or triglycerides. Fatty acid esters have a conditioning effect of softening the skin to create a smoothing sensation. They are also added to cosmetics to dissolve high-polarity active ingredients and UV absorbers. Esters of straight-chain fatty acids and lower alcohols are effective for dissolving slightly soluble ingredients for oils with a light touch during application. Isostearic acids and other liquid oils with branched fatty acids and unsaturated fatty acids are commonly used as emollients. Higher fatty acid esters and esters of higher alcohols with relatively high melting points are added to skin creams to adjust the application touch.

[0938] Oil bodies and emollients: The food, cosmetic or pharmaceutical preparation or homecare product according to the present invention advantageously includes one or more oil bodies or emollients. An emollient is an oleaginous or oily substance which helps to smooth and soften the skin, and may also reduce its roughness, cracking or irritation. Especially, in sunscreen products emollients keep the crystalline and oil-soluble organic and inorganic UV-filters solubilized and prevent them from recrystallisation. In addition, emollients function as wetting agents for inorganic UV-filters for a homogeneous dispersion in the formulations. Suitable oil bodies are, for example, Guerbet alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters of linear C.sub.6-C.sub.22-fatty acids with linear or branched C.sub.6-C.sub.22-fatty alcohols or esters of branched C.sub.6-C.sub.13-carboxylic acids with linear or branched C.sub.6-C.sub.22-fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate and erucyl erucate. Also suitable are esters of linear C.sub.6-C.sub.22-fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of C.sub.18-C.sub.38-alkylhydroxy carboxylic acids with linear or branched C.sub.6-C.sub.22-fatty alcohols, in particular Dioctyl Malate, esters of linear and/or branched fatty acids with polyhydric alcohols (such as, for example, propylene glycol, dimerdiol or trimertriol) and/or Guerbet alcohols, triglycerides based on C.sub.6-C.sub.10-fatty acids, liquid mono-/di-/triglyceride mixtures based on C.sub.6-C.sub.18-fatty acids, esters of C.sub.6-C.sub.22-fatty alcohols and/or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C.sub.2-C.sub.12-dicarboxylic acids with linear or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, linear and branched C.sub.6-C.sub.22-fatty alcohol carbonates, such as, for example, Dicaprylyl Carbonate (Cetiol CC), Guerbet carbonates, based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters of benzoic acid with linear and/or branched C.sub.6-C.sub.22-alcohols (e.g. Finsolv TN), linear or branched, symmetrical or a symmetrical dialkyl ethers having 6 to 22 carbon atoms per alkyl group, such as, for example, dicaprylyl ether (Cetiol OE), ring-opening products of epoxidized fatty acid esters with polyols, silicone oils (cyclomethicones, silicone methicone grades, etc.) and/or aliphatic or naphthenic hydrocarbons, such as, for example, squalane, squalene or dialkylcyclohexanes and any mixture thereof.

[0939] Powders: The compositions as defined herein may optionally include powders. The optional powders provide formulas that are smoother and softer on the skin. Representative powders include talc, mica, magnesium carbonate, calcium carbonate, magnesium silicate, aluminium magnesium silicate, silica, titanium dioxide, zinc oxide, red iron oxide, yellow iron oxide, black iron oxide, polyethylene powder, methacrylate powder, polystyrene powder, silk powder, Preferred solid powder materials, which may be a component of the composition according to the invention are hydrocolloids, such as starches, degraded starches, chemically or physically modified starches, dextrins, (powdery) maltodextrins (preferably with a dextrose equivalent value of 5 to 25, preferably of 10-20), lactose, silicon dioxide, glucose, modified celluloses, gum arabic, ghatti gum, traganth, karaya, carrageenan, pullulan, curdlan, xanthan gum, gellan gum, guar flour, carob bean flour, alginates, agar, pectin, inulin, and mixtures of two or more of these solids, in particular maltodextrins (preferably with a dextrose equivalent value of 15-20), lactose, silicon dioxide and/or glucose.

[0940] Rheology modifiers: The food, cosmetic or pharmaceutical preparation or homecare products according to the present invention advantageously includes one or more thickening agents and/or rheology modifier. The rheology modifier is present in an amount that prevents significant dripping or pooling of the composition after application to the skin or to surfaces. Preferably, the rheology modifier is a carbomer. In some embodiments, the rheology modifier is selected from stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, the polyethylene glycol ether of stearyl alcohol having an average of about 1 to about 21 ethylene oxide units, the polyethylene glycol ether of cetyl alcohol having an average of about 1 to about 5 ethylene oxide units, and mixtures thereof.

[0941] Additional example of rheology modifiers include thickener or gelling agents, including substances which can increase the viscosity of a composition. Thickening agents include those that can increase the viscosity of a composition without substantially modifying the efficacy of the active ingredient within the formulation. Thickening agents can also increase the stability of the formulations of the present application. In certain aspects of the present application, thickening agents include hydrogenated polyisobutene or trihydroxy stearin, or a mixture of both. Additional non-limiting examples of additional thickening agents that can be used in the context of the present application include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums. Examples of carboxylic acid polymers include crosslinked compounds containing one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids and the substituted acrylic acids, wherein the crosslinking agent contains two or more carbon-carbon double bonds and is derived from a polyhydric alcohol (see CTFA International Cosmetic Ingredient Dictionary, Fourth Edition, 1991, pp. 12 and 80). Examples of commercially available carboxylic acid polymers include carbomers, which are homopolymers of acrylic acid crosslinked with allyl ethers of sucrose or pentaerythritol (e.g., Carbopol 900 series from B. F. Goodrich). Non-limiting examples of crosslinked polyacrylate polymers include cationic and non-ionic polymers.

[0942] Non-limiting examples of polyacrylamide polymers (including non-ionic polyacrylamide polymers including substituted branched or unbranched polymers) include polyacrylamide, isoparaffin and Laureth-7, multi-block copolymers of acrylamides and substituted acrylamides with acrylic acids and substituted acrylic acids.

[0943] Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is an alkyl substituted cellulose where the hydroxy groups of the cellulose polymer are hydroxyalkylated (preferably hydroxy ethylated or hydroxypropylated) to form a hydroxyalkylated cellulose which is then further modified with a C10-C30 straight chain or branched chain alkyl group through an ether linkage. Typically, these polymers are ethers of C10-C30 straight or branched chain alcohols with hydroxyalkylcelluloses. Other useful polysaccharides include scleroglucans comprising a linear chain of (1-3) linked glucose units with a (1-6) linked glucose every three unit.

[0944] Non-limiting examples of gums that can be used with the present compositions include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof. In one embodiment, the thickening agent is Chondrus crispus (carrageenan) extract.

[0945] Film formers: The food, cosmetic or pharmaceutical preparation, in particular sunscreen product, or homecare product according to the present invention may advantageously include one or more film formers or film forming agent. A film forming agent is a hydrophobic material that imparts water resistance and film forming characteristics to the sunscreen products, cosmetic or pharmaceutical preparations or homecare products. Standard film formers are preferably chitosan, microcrystalline chitosan, quaternized chitosan, polyvinyl pyrrolidone, vinyl pyrrolidone/vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid and salts thereof and similar compounds. Preferred film formers for improving water resistance of the composition are selected from the group consisting of Polyamide-8 (such as Oleocraft LP 20 PA (MV)), Polyamide-3 (such as Oleocraft MP 32 PA (MV)), Trimethylpentanediol/Adipic Acid/Glycerin Crosspolymer (such as WetFilm), Octyldodecyl Citrate Crosspolymer (such as CosmoSurf CE 100), Polyglyceryl-3 Methyl Glucose Distearate (such as TegoCare 450), C28-52 Olefin/Undecylenic Acid Copolymer (such as Performa V6112), Hydrolyzed Jojoba esters, Jojoba Esters, Aqua (such as Floraester Jojoba K100), Cyclopentasiloxane Acrylates/Dimethicone copolymer (such as KP545), Acrylates/Beheneth-25 Methacylate Copolymer (such as Volarest), Styrene/Acrylates Copolymer (such as Dermacryl E Polymer), Polyurethane (such as Baycusan C1001), Polyurethane-2 and Polymethyl Methacrylate (such as Hybridur 875 Polymer), Acrylates/Octylacrylamide Copolymer (such as Dermacryl 2.0 Polymer), Beeswax (Cera Alba) (and) Sodium Stearoyl Lactylate (such as SymEffect Sun), Pullulan, Xanthan Gum, Hydrogenated Palm Oil, Saccharum Officinarum Extract (SymEffectUV), Microcrystalline cellulose (and) Sphingomonas ferment extract (and) Cellulose gum (such as PemuPur START Polymer), Acacia Senegal Gum and Xanthan Gum (such as SOLAGUM AX), Microcrystalline Cellulose (and) Cellulose Gum (such as Natpure Cellgum Plus), Sodium Stearoyl Glutamate (such as AMISOFT HS-11P), Hydrogenated Polycyclopentadiene (and) Caprylic/Capric Triglyceride (such as Koboguard 5400 CCT), Glyceryl Hydrogenated Rosinate (and) Caprylic/Capric Triglyceride (and) Tocopherol (such as KOBOGUARD NATURAL 2063-CCT), Galactoarabinan (such as LaraCare A 200), C26-28 Alkyl Dimethicone (such as Wacker BELSIL CDM 3526 VP), Caprylyl Methicone (such as Silsoft 034), Stearyl Dimethicone (and) Octadecene (such as Dowsil 2503 Cosmetic Wax), VP/Hexadecene Copolymer (such as Antaron V 216), Triacontanyl PVP (such as Antaron WP-660), Capryloyl Glycerin/Sebacic Acid Copolymer (such as LexFilm Sun Natural MB), Poly C10-30 Alkyl Acrylate (such as Tego SP 13 Sun Up), Microcrystalline Cellulose (such as Sunspheres BIO SPF Booster), and any mixture thereof. The aforesaid film forming agents are used in the sunscreen, cosmetic or pharmaceutical preparation or homecare product either as a single component or preferably in a mixture with two or more further of said film forming agents as specified above. The film forming agents are used in amounts effective to allow the final formulation to remain on the skin or surface after exposure to circulating water for at least 40 minutes, preferably 80 minutes. The film forming agent is present in the preparations in an amount of 0.01 to 10.0% by weight, preferably 0.05 to 8.0% by weight, based on the total weight of the final formulation.

[0946] Water resistance improving agents: The food, cosmetic or pharmaceutical preparation or homecare product according to the present invention may advantageously include one or more agents for improving water resistance. An agent for improving water resistance is a hydrophobic material that imparts film forming and water resistance characteristics to an emulsion. Typical suitable water resistance improving agents include copolymers derived from polymerization of octadecene-1 and maleic anhydride. A preferred water resistance improving agent is a polyanhydride resin. Another preferred water resistance improving agent is a copolymer of vinyl pyrrolidone and eicosene monomers. The water resistance improving agent(s) is/are used in amounts effective to allow the final formulation to remain on the skin or surface after exposure to circulating water for at least 40 minutes, preferably 80 minutes. One or more water resistance improving agents can optionally be included in the final formulation in an amount ranging from 0.01 to 10.0% by weight, preferably 0.05 to 8.0% by weight, more preferably 0.1 to 5.0% by weight, based on the total weight of the final formulation.

[0947] Silicones: In order to impart a silky, spreadable, and luxurious texture and to make skin look and feel smoother, and additionally to improve processability (antifoaming) the sunscreen product or cosmetic or pharmaceutical preparation according to the present invention preferably includes one or more silicones or silicone derivatives commonly used in the art. The total amount of silicone compound(s) in the compositions according to the present invention can vary but is typically 0.1 to 20% by weight, based on the total weight of the composition.

[0948] Dry-feel modifiers: The sunscreen product or cosmetic or pharmaceutical preparation according to the present invention is preferably combined with dry-feel modifiers. A dry-feel modifier is an agent which, when incorporated in an emulsion, imparts a dry feel to the skin when the emulsion dries. Dry-feel modifiers may also reduce sunscreen migration on the skin. Dry feel modifiers can include starches, talc, kaolin, chalk, zinc oxide, Hydroxyapatite (such as Tinomax CC), silicone fluids, inorganic salts such as barium sulfate and sodium chloride, C6 to C12 alcohols such as octanol; sulfonated oils; surface treated silica, precipitated silica, fumed silica such as Aerosil available from the Degussa Inc. of New York, N.Y. U.S.A. or mixtures thereof; dimethicone, a mixture of mixture of methylated linear siloxane polymers, available as DC200 fluid, tradename of Dow Corning, Midland, Mich. U.S.A. One or more dry-feel modifiers can optionally be included in the sunscreen in amounts ranging from 0.01 to 20% by weight, more preferably from 0.1 to 10.0% by weight.

[0949] Lenitive substances: The sunscreen product or cosmetic or pharmaceutical preparation according to the present invention can also contain advantageously one or more lenitive substances, wherein any lenitive substances can be used which are suitable or customary in cosmetic or pharmaceutical applications such as alpha-bisabolol, azulene, guaiazulene, 18-beta-glycyrrhetinic acid, allantoin, Aloe vera juice or gel, extracts of Hamamelis virginiana (witch hazel), Echinacea species, Centella asiatica, chamomile, Arnica montana, Glycyrrhiza species, algae, seaweed and Calendula officinalis, and vegetable oils such as sweet almond oil, baobab oil, olive oil and panthenol, Laureth-9, Trideceth-9 and 4-t-butylcyclohexanol.

[0950] Physiological cooling agents: The sunscreen product or cosmetic or pharmaceutical preparation according to the present invention can be particularly advantageously combined with one or more physiological cooling agent(s). The use of cooling agents can alleviate itching. Preferred individual cooling agents for use within the framework of the present invention are listed below. The person skilled in the art can add many other cooling agents to this list; the cooling agents listed can also be used in combination with one another: which are preferably selected here from the following list: menthol and menthol derivatives (for example L-menthol, D-menthol, racemic menthol, isomenthol, neoisomenthol, neomenthol) menthylethers (for example (I-menthoxy)-1,2-propanediol, (I-menthoxy)-2-methyl-1,2-propanediol, I-menthyl-methylether), menthone glyceryl acetal, menthone glyceryl ketal or mixtures of both, menthylesters (for example menthylformiate, menthylacetate, menthylisobutyrate, menthyhydroxyisobutyrat, menthyllactates, L-menthyl-L-lactate, L-menthyl-D-lactate, menthyl-(2-methoxy)acetate, menthyl-(2-methoxyethoxy-) acetate, menthylpyroglutamate), menthylcarbonates (for example menthylpropyleneglycolcarbonate, menthylethyleneglycolcarbonate, menthylglycerolcarbonate or mixtures thereof), the semi-esters of menthols with a dicarboxylic acid or derivatives thereof (for example mono-menthylsuccinate, mono-menthylglutarate, mono-menthylmalonate, O-menthyl succinic acid ester-N,N-(dimethyl) amide, O-menthyl succinic acid ester amide), menthanecarboxylic acid amides (in this case preferably menthanecarboxylic acid-N-ethylamide [WS3] or N.sup.-(menthanecarbonyl) glycinethylester [WS5], menthanecarboxylic acid-N-(4-cyanophenyl) amide or menthanecarboxylic acid-N-(4-cyanomethylphenyl) amide, menthanecarboxylic acid-N-(alkoxyalkyl) amides), menthone and menthone derivatives (for example L-menthone glycerol ketal), 2,3-dimethyl-2-(2-propyl)-butyric acid derivatives (for example 2,3-dimethyl-2-(2-propyl)-butyric acid-N-methylamide [WS23]), isopulegol or its esters (I-()-isopulegol, I-()-isopulegolacetate), menthane derivatives (for example p-menthane-3,8-diol), cubebol or synthetic or natural mixtures, containing cubebol, pyrrolidone derivatives of cycloalkyldione derivatives (for example 3-methyl-2 (1-pyrrolidinyl)-2-cyclopentene-1-one) or tetrahydropyrimidine-2-one (for example iciline or related compounds, as described in WO 2004/026840), further carboxamides (for example N-(2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide or related compounds), (1R,2S,5R)N-(4-Methoxyphenyl)-5-methyl-2-(1-isopropyl) cyclohexane-carboxamide [WS12], oxamates and [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] 2-(ethylamino)-2-oxo-acetate (X Cool). Cooling agents which are preferred due to their particular synergistic effect are I-menthol, d-menthol, racemic menthol, menthone glycerol acetal (trade name: Frescolat MGA), menthyl lactate (preferably I-menthyl lactate, in particular I-menthyl I-lactate (trade name: Frescolat ML)), substituted menthyl-3-carboxamides (such as menthyl-3-carboxylic acid N-ethyl amide), 2-isopropyl-N-2,3-trimethyl butanamide, substituted cyclohexane carboxamides, 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate, 2-hydroxypropyl menthyl carbonate and isopulegol. Particularly preferred cooling agents are I-menthol, racemic menthol, menthone glycerol acetal (trade name: Frescolat MGA), menthyl lactate (preferably I-menthyl lactate, in particular I-menthyl I-lactate (trade name: Frescolat ML)), 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate and 2-hydroxypropyl menthyl carbonate. Very particularly preferred cooling agents are I-menthol, menthone glycerol acetal (trade name: Frescolat MGA) and menthyl lactate (preferably I-menthyl lactate, in particular I-menthyl I-lactate (trade name: Frescolat ML).

[0951] Alkanediols: In a further preferred variant, the food, cosmetic or pharmaceutical preparation or homecare product according to the invention comprises one or more linear alkanediol(s) having a carbon chain of 5 to 12 carbon atoms. Preferably, said one or more linear alkanediol(s) is/are selected from the group consisting of 1,2-alkanediols, 2,3-alkanediols, 3,4-alkanediols and 1,3-alkanediols, more preferably of 2,3-alkanediols and 1,3-alkanediols. Most preferably, said linear alkanediol(s) is/are selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol and 2,3-dodecanediol.

[0952] Initial observations of the inventors surprisingly indicated that compositions according to the invention comprising one or more linear alkanediol(s) having a carbon chain of 5 to 12 carbon atoms, preferably as defined herein, display particularly advantageous emulsifying properties. In particular, it was surprisingly found that the one or more of said linear alkanediol(s) (if not emulsions themselves) support(s) the formation of water or oil droplets with a particularly small average size in emulsions or (if emulsions themselves) contain water or oil droplets with a particularly small average size.

[0953] Additionally, it was found that the presence of an alkanediol, in particular a 1,2-alkanediol or 2,3-alkanediol, improves the solubility of oil components, such as one or more oil body/bodies or wax(es) in the food, cosmetic or pharmaceutical preparation or homecare product according to the present invention. Preferably the oil body/bodies or wax(es) are selected from the group consisting of natural fats and oils, fatty alcohols and alcohols, glyceryl esters and derivatives thereof, esters, ethers, siloxanes and silanes, waxes, and naphthenic hydrocarbons, preferably selected from the group consisting of squalene, dialkylcyclohexanes, tetradecane, isohexadecane, dodecane, docosane, paraffin, and mineral oils, and further described below.

[0954] A combination of one or more of said alkanediol(s) with 4-hydroxyacetophenon, typically in amounts from 0.1 to 2% by weight, more preferably from 0.1 to 1% by weight, improves the solubility of the oil components even in a synergistic manner.

[0955] Preferably, the composition comprises from 0.01 to 10% by weight, more preferably from 0.1 to 5% by weight, still more preferably from 0.3 to 3% by weight, most preferably from 0.5 to 1% by weight, of said linear alkanediol(s) having a carbon chain of 5 to 12 carbon atoms and defined herein, based on the total weight of the composition.

[0956] Antioxidants: The food, cosmetic or pharmaceutical preparation or homecare product according to the present invention comprises advantageously one or more antioxidants. Suitable antioxidants encompass amino acids (preferably glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (preferably urocanic acid) and derivatives thereof, peptides, preferably D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (preferably anserine), carnitine, creatine, matrikine peptides (preferably lysyl-threonyl-threonyl-lysyl-serine) and palmitoylated pentapeptides, carotenoids, carotenes (preferably alpha-carotene, beta-carotene, lycopene) and derivatives thereof, lipoic acid and derivatives thereof (preferably dihydrolipoic acid), aurothioglucose, propyl thiouracil and other thiols (preferably thioredoxine, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, gamma-linoleyl, cholesteryl, glyceryl and oligoglyceryl esters thereof) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (preferably esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (preferably buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathionine sulfoximine) in very small tolerated doses (e.g. pmol to mol/kg), also (metal) chelators (preferably alpha-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin, alpha-hydroxy acids (preferably citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, tannins, bilirubin, biliverdin, EDTA, EGTA and derivatives thereof), unsaturated fatty acids and derivatives thereof (preferably gamma-linolenic acid, linoleic acid, oleic acid), folic acid and derivatives thereof, ubiquinone and derivatives thereof, ubiquinol and derivatives thereof, vitamin C and derivatives (preferably ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate, ascorbyl glucoside), tocopherols and derivatives (preferably vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoic resin, rutinic acid and derivatives thereof, flavonoids and glycosylated precursors thereof, in particular quercetin and derivatives thereof, preferably alpha-glucosyl rutin, rosmarinic acid, carnosol, carnosolic acid, resveratrol, caffeic acid and derivatives thereof, sinapic acid and derivatives thereof, ferulic acid and derivatives thereof, curcuminoids, chlorogenic acid and derivatives thereof, retinoids, preferably retinyl palmitate, retinol or tretinoin, ursolic acid, levulinic acid, butyl hydroxytoluene, butyl hydroxyanisole, nordihydroguaiac acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (preferably ZnO, ZnSO.sub.4), selenium and derivatives thereof (preferably selenium methionine), superoxide dismutase, stilbenes and derivatives thereof (preferably stilbene oxide, trans-stilbene oxide) and the derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these cited active ingredients which are suitable according to the invention or extracts or fractions of plants having an antioxidant effect, preferably green tea, rooibos, honeybush, grape, rosemary, sage, melissa, thyme, lavender, olive, oats, cocoa, ginkgo, ginseng, liquorice, honeysuckle, sophora, pueraria, pinus, citrus, Phyllanthus emblica or St. John's wort, grape seeds, wheat germ, Phyllanthus emblica, coenzymes, preferably coenzyme Q10, plastoquinone and menaquinone. Preferred antioxidants are selected from the group consisting of vitamin A and derivatives, vitamin C and derivatives, tocopherol and derivatives, preferably tocopheryl acetate, and ubiquinone.

[0957] Emulsifiers: In addition, the food, cosmetic or pharmaceutical preparation or homecare product according to the present invention can also advantageously contain one or more emulsifiers in order to keep the food, cosmetic or pharmaceutical preparation or homecare product stable. Emulsifiers include amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture. The emulsifiers are chosen in an appropriate manner according to the emulsion to be obtained. Preferred examples include: [0958] products of the addition of 2 to 30 mol ethylene oxide and/or 0 to 5 mol propylene oxide onto linear C.sub.8-22 fatty alcohols, onto C.sub.12-22 fatty acids and onto alkyl phenols containing 8 to 15 carbon atoms in the alkyl group; [0959] C.sub.12/18 fatty acid monoesters and diesters of addition products of 1 to 30 mol ethylene oxide onto glycerol; [0960] glycerol mono- and diesters and sorbitan mono- and diesters of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms and ethylene oxide addition products thereof; [0961] addition products of 15 to 60 mol ethylene oxide onto castor oil and/or hydrogenated castor oil; [0962] polyol esters and in particular, polyglycerol esters such as, for example, polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate or polyglycerol dimerate isostearate. Mixtures of compounds from several of these classes are also suitable; [0963] addition products of 2 to 15 mol ethylene oxide onto castor oil and/or hydrogenated castor oil; [0964] partial esters based on linear, branched, unsaturated or saturated C.sub.6/22 fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (for example sorbitol), alkyl glucosides (for example methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (for example cellulose); [0965] mono-, di and trialkyl phosphates and mono-, di- and/or tri-PEG-alkyl phosphates and salts thereof; [0966] wool wax alcohols; [0967] polysiloxane/polyalkyl polyether copolymers and corresponding derivatives; [0968] mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol and/or mixed esters of C6-22 fatty acids, methyl glucose and polyols, preferably glycerol or polyglycerol, [0969] polyalkylene glycols and [0970] glycerol carbonate.

[0971] The addition products of ethylene oxide and/or propylene oxide onto fatty alcohols, fatty acids, alkylphenols, glycerol mono- and diesters and sorbitan mono- and diesters of fatty acids or onto castor oil are known commercially available products. They are homologue mixtures of which the average degree of alkoxylation corresponds to the ratio between the quantities of ethylene oxide and/or propylene oxide and substrate with which the addition reaction is carried out. C.sub.12/18 fatty acid monoesters and diesters of addition products of ethylene oxide onto glycerol are known as lipid layer enhancers for cosmetic formulations. The preferred emulsifiers are described in more detail as follows:

[0972] Partial glycerides: Typical examples of suitable partial glycerides are hydroxystearic acid monoglyceride, hydroxystearic acid diglyceride, isostearic acid monoglyceride, isostearic acid diglyceride, oleic acid monoglyceride, oleic acid diglyceride, ricinoleic acid monoglyceride, ricinoleic acid diglyceride, linoleic acid monoglyceride, linoleic acid diglyceride, linolenic acid monoglyceride, linolenic acid diglyceride, erucic acid monoglyceride, erucic acid diglyceride, tartaric acid monoglyceride, tartaric acid diglyceride, citric acid monoglyceride, citric acid diglyceride, malic acid monoglyceride, malic acid diglyceride and technical mixtures thereof which may still contain small quantities of triglyceride from the production process. Addition products of 1 to 30 and preferably 5 to 10 mol ethylene oxide onto the partial glycerides mentioned are also suitable.

[0973] Sorbitan esters: Suitable sorbitan esters are sorbitan monoisostearate, sorbitan sesquiisostearate, sorbitan diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan dioleate, sorbitan trioleate, sorbitan monoerucate, sorbitan sesquierucate, sorbitan dierucate, sorbitan trierucate, sorbitan monoricinoleate, sorbitan sorbitan sesquiricinoleate, diricinoleate, sorbitan triricinoleate, sorbitan monohydroxystearate, sorbitan sesquihydroxystearate, sorbitan dihydroxystearate, sorbitan trihydroxystearate, sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimaleate and technical mixtures thereof. Addition products of 1 to 30 and preferably 5 to 10 mol ethylene oxide onto the sorbitan esters mentioned are also suitable.

[0974] Polyglycerol esters: Typical examples of suitable polyglycerol esters are Polyglyceryl-2 Dipolyhydroxystearate (Dehymuls PGPH), Polyglycerin-3-Diisostearate (Lameform TGI), Polyglyceryl-4 Isostearate (Isolan GI 34), Polyglyceryl-3 Oleate, Diisostearoyl Polyglyceryl-3 Diisostearate (Isolan PDI), Poly-glyceryl-3 Methylglucose Distearate (Tego Care 450), Polyglyceryl-3 Beeswax (Cera Bellina), Polyglyceryl-4 Caprate (Polyglycerol Caprate T2010/90), Polyglyceryl-3 Cetyl Ether (Chimexane NL), Polyglyceryl-3 Distearate (Cremophor GS 32) and Polyglyceryl Polyricinoleate (Admul WOL 1403), Polyglyceryl Dimerate Isostearate and mixtures thereof. Examples of other suitable polyolesters are the mono-, di- and triesters of trimethylol propane or pentaerythritol with lauric acid, cocofatty acid, tallow fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like optionally reacted with 1 to 30 mol ethylene oxide.

[0975] Anionic emulsifiers: Typical anionic emulsifiers are aliphatic C12 to C22 fatty acids, such as palmitic acid, stearic acid or behenic acid for example, and C12 to C22 dicarboxylic acids, such as azelaic acid or sebacic acid for example, potassium cetyl phosphate, and hydrogenated palm glycerides (Emulsiphos/Emulsiphos F).

[0976] Amphoteric emulsifiers: Other suitable emulsifiers are amphoteric or zwitterionic surfactants. Zwitterionic surfactants are surface-active compounds which contain at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines, such as the N-alkyl-N, N-dimethyl ammonium glycinates, for example cocoalkyl dimethyl ammonium glycinate, N-acylaminopropyl-N, N-dimethyl ammonium glycinates, for example cocoacylaminopropyl dimethyl ammonium glycinate, and 2-alkyl-3-carboxymethyl-3-hydroxyethyl imidazolines containing 8 to 18 carbon atoms in the alkyl or acyl group and cocoacylaminoethyl hydroxyethyl carboxymethyl glycinate. The fatty acid amide derivative known under the CTFA name of Cocamidopropyl Betaine is particularly preferred. Ampholytic surfactants are also suitable emulsifiers. Ampholytic surfactants are surface-active compounds which, in addition to a C.sub.8/18 alkyl or acyl group, contain at least one free amino group and at least one COOH or SO.sub.3H group in the molecule and which are capable of forming inner salts. Examples of suitable ampholytic surfactants are N-alkyl glycines, N-alkyl propionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropyl glycines, N-alkyl taurines, N-alkyl sarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids containing around 8 to 18 carbon atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-coco-alkylaminopropionate, cocoacylaminoethyl aminopropionate and C12/18 acyl sarcosine.

[0977] Anti-ageing actives: A composition according to the present invention is preferably combined with one or more anti-ageing actives. In the context of the invention, anti-ageing or biogenic agents are, for example antioxidants, matrix-metalloproteinase inhibitors (MMPI), skin moisturizing agents, glycosaminglycan stimulators, anti-inflammatory agents, TRPV1 antagonists and plant extracts.

[0978] Matrix-Metalloproteinase inhibitors (MMPI): The compositions according to the present invention are preferably combined with one or more matrix-metalloproteinase inhibitors, especially those inhibiting matrix-metalloproteinases enzymatically cleaving collagen, selected from the group consisting of ursolic acid, retinyl palmitate, propyl gallate, precocenes, 6-hydroxy-7-methoxy-2,2-dimethyl-1 (2H)-benzopyran, 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1 (2H)-benzopyran, benzamidine hydrochloride, the cysteine proteinase inhibitors N-ethylmalemide and epsilon-amino-n-caproic acid of the serinprotease inhibitors: phenylmethylsufonylfluoride, collhibin (company Pentapharm; INCI: hydrolysed rice protein), oenotherol (company Soliance; INCI: propylene glycol, aqua, Oenothera biennis root extract, ellagic acid and ellagitannins, for example from pomegranate), phosphoramidone hinokitiol, EDTA, MGDA (Trisodiumdicarboxymethyl alaninante), galardin, EquiStat (company Collaborative Group; apple fruit extract, soya seed extract, ursolic acid, soya isoflavones and soya proteins), sage extracts, MDI (company Atrium; INCI: glycosaminoglycans), fermiskin (company Silab/Mawi; INCI: water and lentinus edodes extract), actimp 1.9.3 (company Expanscience/Rahn; INCI: hydrolysed lupine protein), lipobelle soyaglycone (company Mibelle; INCI: alcohol, polysorbate 80, lecithin and soy isoflavones), extracts from green and black tea and further plant extracts, proteins or glycoproteins from soya, hydrolysed proteins from rice, pea or lupine, plant extracts which inhibit MMPs, preferably extracts from shittake mushrooms, extracts from the leaves of the Rosaceae family, sub-family Rosoideae, quite particularly extracts of blackberry leaf, as e.g. SymMatrix (company Symrise, INCI: Maltodextrin, Rubus Fruticosus (Blackberry) Leaf Extract). Preferred actives of are selected from the group consisting of retinyl palmitate, ursolic acid, extracts from the leaves of the Rosaceae family, sub-family Rosoideae, genistein and daidzein.

[0979] Skin moisturizing and/or moisture-retaining substances: The compositions according to the present invention advantageously comprise one or more skin-moisturizing and/or moisture-retaining substances. Preferred skin moisturizing and/or moisture-retaining substances are selected from the group consisting of alkane diols or alkane triols comprising 3 to 12 carbon atoms, preferably C3-C10-alkane diols and C3-C10-alkane triols. More preferably the skin moisturizing agents are selected from the group consisting of glycerol, 1,2-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol and 1,2-decanediol. Further skin moisturizing and/or moisture-retaining substances include sodium lactate, urea, urea derivatives, alcohols, glycerol, diols such as propylene glycol, hexylene glycol, collagen, elastin or hyaluronic acid, diacyl adipates, petrolatum, urocanic acid, lecithin, panthenol, phytantriol, lycopene, (pseudo-) ceramides, glycosphingolipids, cholesterol, phytosterols, chitosan, chondroitin sulphate, lanolin, lanolin esters, amino acids, alpha-hydroxy acids (such as citric acid, lactic acid, malic acid) and their derivatives, mono-, di- and oligosaccharides such as glucose, galactose, fructose, mannose, fructose and lactose, polysugars such as R-glucans, in particular 1,3-1,4--glucan from oats, alpha-hydroxy fatty acids, triterpene acids such as betulinic acid or ursolic acid, and algae extracts.

[0980] Glycosaminoglycan stimulators: Preferred compositions according to the present invention comprise one or more substances stimulating the synthesis of glycosaminoglycans which are selected from the group consisting of hyaluronic acid and derivatives or salts, Subliskin (Sederma, INCI: Sinorhizobium Meliloti Ferment Filtrate, Cetyl Hydroxyethylcellulose, Lecithin), Hyalufix (BASF, INCI: Water, Butylene Glycol, Alpinia galanga leaf extract, Xanthan Gum, Caprylic/Capric Triglyceride), Stimulhyal (Soliance, INCI: Calcium ketogluconate), Syn-Glycan (DSM, INCI: Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Glycerin, Magnesium chloride), Kalpariane (Biotech Marine), DC Upregulex (Distinctive Cosmetic Ingredients, INCI: Water, Butylene Glycol, Phospholipids, Hydrolyzed Sericin), glucosamine, N-acetyl glucosamine, retinoids, preferably retinol and vitamin A, Arctium lappa fruit extract, Eriobotrya japonica extract, Genkwanin, N-Methyl-L-serine, ()-alpha-bisabolol or synthetic alpha-bisabolol such as e.g. Dragosantol and Dragosantol 100 from Symrise, oat glucan, Echinacea purpurea extract and soy protein hydrolysate. Preferred actives are selected from the group consisting of hyaluronic acid and derivatives or salts, retinol and derivatives, ()-alpha-bisabolol or synthetic alpha-bisabolol such as e.g. Dragosantol and Dragosantol 100 from Symrise, oat glucan, Echinacea purpurea extract, Sinorhizobium Meliloti Ferment Filtrate, Calcium ketogluconate, Alpinia galanga leaf extract and tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate.

[0981] Anti-inflammatory agents: The compositions according to the present invention are preferably combined with anti-inflammatory and/or redness and/or itch ameliorating ingredients, in particular steroidal substances of the corticosteroid type selected from the group consisting of hydrocortisone, dexamethasone, dexamethasone phosphate, methyl prednisolone or cortisone, are advantageously used as anti-inflammatory active ingredients or active ingredients to relieve reddening and itching, the list of which can be extended by the addition of other steroidal anti-inflammatories. Non-steroidal anti-inflammatoires can also be used. More particularly: [0982] (i) steroidal anti-inflammatory substances of the corticosteroid type, in particular hydrocortisone, hydrocortisone derivatives such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone, [0983] (ii) non-steroidal anti-inflammatory substances, in particular oxicams such as piroxicam or tenoxicam, salicylates such as aspirin, disalcid, solprin or fendosal, acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac, fenamates such as mefenamic, meclofenamic, flufenamic or niflumic, propionic acid derivatives such as ibuprofen, naproxen or benoxaprofen, pyrazoles such as phenylbutazone, oxyphenylbutazone, febrazone or azapropazone, [0984] (iii) natural or naturally occurring anti-inflammatory substances or substances that alleviate reddening and/or itching, in particular extracts or fractions from camomile, Aloe vera, Commiphora species, Rubia species, willow, willow-herb, oats, calendula, arnica, St John's wort, honeysuckle, rosemary, Passiflora incarnata, witch hazel, ginger or Echinacea, or single active compounds thereof, [0985] (iv) histamine receptor antagonists, serine protease inhibitors (e.g. of Soy extracts), TRPV1 antagonists (e.g. 4-t-Butylcyclohexanol), NK1 antagonists (e.g. Aprepitant, Hydroxyphenyl Propamidobenzoic Acid), cannabinoid receptor agonists (e.g. Palmitoyl Ethanolamine) and TRPV3 antagonists.

[0986] Examples which can be cited here are oxicams such as piroxicam or tenoxicam; salicylates such as aspirin, disalcid, solprin or fendosal; acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac; fenamates such as mefenamic, meclofenamic, flufenamic or niflumic; propionic acid derivatives such as ibuprofen, naproxen, benoxaprofen or pyrazoles such as phenylbutazone, oxyphenylbutazone, febrazone or azapropazone. Anthranilic acid derivatives are preferred anti-itch ingredients in a composition according to the present invention.

[0987] Also useful are natural or naturally occurring anti-inflammatory mixtures of substances or mixtures of substances that alleviate reddening and/or itching, in particular extracts or fractions from camomile, Aloe vera, Commiphora species, Rubia species, willow, willow-herb, oats, calendula, arnica, St John's wort, honeysuckle, rosemary, Passiflora incarnata, witch hazel, ginger or Echinacea; preferably selected from the group consisting of extracts or fractions from camomile, Aloe vera, oats, calendula, arnica, honeysuckle, rosemary, witch hazel, ginger or Echinacea, and/or pure substances, preferably alpha-bisabolol, apigenin, apigenin-7-glucoside, gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols, natural or naturally occurring avenanthramides, preferably tranilast, avenanthramide A, avenanthramide B, avenanthramide C, non-natural or non-naturally occuring avenanthramides, preferably dihydroavenanthramide D, dihydroavenanthramide E, avenanthramide D, avenanthramide E, avenanthramide F, boswellic acid, phytosterols, glycyrrhizin, glabridin and licochalcone A; preferably selected from the group consisting of alpha-bisabolol, natural avenanthramides, non-natural avenanthramides, preferably dihydroavenanthramide D (as described in WO 2004 047833 A1), boswellic acid, phytosterols, glycyrrhizin, and licochalcone A, and/or allantoin, panthenol, lanolin, (pseudo-) ceramides [preferably Ceramide 2, hydroxypropyl bispalmitamide MEA, cetyloxypropyl glyceryl methoxypropyl myristamide, N-(1-hexadecanoyl)-4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethyl palmityl oxyhydroxypropyl palmitamide], glycosphingolipids, phytosterols, chitosan, mannose, lactose and -glucans, in particular 1,3->1,4--glucan from oats.

[0988] TRPV1 antagonists: Preferred compositions according to the present invention comprise one or more TRPV1 antagonists. Suitable compounds which reduce the hypersensitivity of skin nerves based on their action as TRPV1 antagonists, encompass e.g., trans-4-tert-butyl cyclohexanol, or indirect modulators of TRPV1 by an activation of the -receptor, e.g., acetyl tetrapeptide-15, are preferred.

[0989] Preservatives: For preservative purposes, the compositions according to the present invention preferably comprise one or more preservatives. Suitable and advantageously preservatives are, for example, benzoic acid, sodium benzoate, ammonium benzoate, butyl benzoate, calcium benzoate, ethyl benzoate, isobutyl benzoate, isopropyl benzoate, magnesium benzoate, mea-benzoate, methyl benzoate, phenyl benzoate, potassium benzoate, propyl benzoate, propionic acid, ammonium propionate, calcium propionate, magnesium propionate, potassium propionate, sodium propionate, salicylic acid, calcium salicylate, magnesium salicylate, measalicylate, sodium salicylate, potassium salicylate, teasalicylate, sorbic acid, calcium sorbate, sodium sorbate, potassium sorbate, o-phenylphenol, sodium sulfite, ammonium bisulfite, ammonium sulfite, potassium sulfite, potassium hydrogen sulfite, sodium bisulfite, sodium metabisulfite, potassium metabisulfite, chlorobutanol, 4-hydroxybenzoic acid, methylparaben, potassium ethylparaben, potassium paraben, sodium methylparaben, sodium ethylparaben, ethylparaben, sodium paraben, potassium methylparaben, calcium paraben, butylparaben, propylparaben, sodium propoylparaben, sodium butylparaben, potassium butylparaben, potassium propylparaben, dehydroacetic acid, sodium dehydroacetate, formic acid, sodium formate, dibromohexamidine isethionate, thimerosal, phenyl mercuric acetate, phenyl mercuric benzoate, undecylenic acid, potassium undecylenate, sodium undecylenate, calcium undecylenate, mea-undecylenate, tea-undecylenate, hexetidine, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitropropane-1,3-diol, dichlorobenzyl alcohol, triclocarban, p-chloro-m-cresol, triclosan, chloroxylenol, imidazolidinyl urea, polyaminopropyl; biguanide, phenoxyethanol, methenamine, climbazole, DMDM hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon, piroctone olamine, bromochlorophene, o-cymen-5-ol, methylchloroisothiazolinone and methylisothiazolinone, chlorhexidine, chlorhexidine diacetate, chlorhexidine digluconate, chlorhexidine dihydrochloride, phenoxyisopropanol, behentrimonium chloride (1), cetrimonium bromide, cetrimonium chloride (2), laurtrimoniumbromide, laurtrimonium chloride, steartrimonium bromide, steartrimonium chloride (2), dimethyl oxazolidine, diazolidinyl urea, hexamidine, hexamidine diisethionate, hexamidine diparaben, hexamidine paraben, glutaral, 7-ethylbicyclooxazolidine, chlorphenesin, sodium hydroxymethylglycinate, silver chloride, benzethonium chloride, benzalkonium chloride, benzalkonium bromide, benzalkonium saccharinate, benzylhemiformal, iodopropynyl butylcarbamate, methylisothiazolinone, citric acid, silver citrate, hydroxyethoxy-phenyl butanone (HEPB) and any mixture thereof.

[0990] Antibacterial or antimycotic active substances: In addition to the antimicrobials as described therein, antibacterial or antimycotic active substances can also particularly advantageously be used in the compositions according to the present invention, wherein any antibacterial or antimycotic active substances can be used which are suitable or customary in cosmetic or pharmaceutical, in particular dermatological applications. In addition to the large group of conventional antibiotics, other products which are advantageous here include those relevant to cosmetics such as in particular triclosan, climbazole, octoxyglycerin, Octopirox (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 (1H)-pyridone 2-aminoethanol salt), chitosan, farnesol, glycerol monolaurate or combinations of said substances.

[0991] UV-filters: The composition as defined herein, is advantageously combined with at least one primary sun protection factor and/or with at least one secondary sun protection factor, in order to increase the SPF, i.e. to obtain a high SPF and to cover a broad UVA and UVB range.

[0992] The compositions according to the invention advantageously contains at least one UVA filter and/or at least one further UVB filter and/or a broadband filter and/or at least one inorganic pigment, preferably at least one UVA filter and at least one UVB filter for their use in stopping UV radiation.

[0993] For example, the at least one primary UV-filter may be one or more organic UV-filters and/or one or more inorganic UV-filters. Non-limiting examples of UV-filters include: [0994] (i) sparingly soluble UV-filters (not appreciably soluble in either water or oil) such as Methylene Bis-benzotriazolyl Tetramethylbutylphenol, Tris-Biphenyl Triazine, Methanone, 1,1-(1,4-piperazinediyl) bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl-]phenyl]; [0995] (ii) oil soluble organic UV-filters (at least partially soluble in oil or organic solvent), such as Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Butyl Methoxydibenzoylmethane (BMBM), Oxybenzone, Sulisobenzone, Diethylhexyl Drometrizole Butamido Triazone (DBT), Trisiloxane, Ethylhexyl Methoxycinnamate (EHMC), Ethylhexyl Salicylate (EHS), Ethylhexyl Triazone (EHT), Homosalate, Isoamyl p-Methoxycinnamate, 4-Methylbenzylidene Camphor, Octocrylene (OCR), Polysilicone-15, and Diethylamino Hydroxy Benzoyl Hexyl Benzoate (DHHB); [0996] (iii) inorganic UV-filters such as titanium oxide and zinc oxide, iron oxide, zirconium oxide and cerium oxide; and [0997] (iv) water soluble UV-filters such as Phenylbenzimidazole Sulfonic Acid (PBSA), Sulisobenzone-sodium salt, Benzydilene Camphor Sulfonic Acid, Camphor Benzalkonium Methosulfate, Cinoxate, Disodium Phenyl Dibenzylmidazole Tetrasulfonate, Terephthalylidene Dicamphor Sulfonic Acid, PABA, and PEG-25 PAB; and any mixture thereof.

[0998] Many different organic compounds can serve as UV-filters. They fall into several structural classes: [0999] (2) Benzophenones [1000] a. Benzophenone-3 (BP3) [1001] b. Benzophenone-4 (BP4) [1002] (3) Salicylates [1003] a. Homosalate (HMS) [1004] b. 2-ethylhexyl salicylate (EHS) [1005] (4) p-Aminobenzoic acid and derivatives [1006] a. Ethylhexyl dimethyl PABA (OD-PABA) [1007] b. 4-p-aminobenzoic acid (PABA) [1008] (5) Benzimidazole derivatives [1009] a. Phenylbenzimidazole sulfonic acid (PMDSA) [1010] b. Disodium phenyl dibenzimidazole tetrasulfonate (bisdisulizole disodium) [1011] (6) Triazines [1012] a. Ethylhexyltriazone (OT) [1013] b. Diethylhexyl butamido triazone (DBT) [1014] c. Bis-ethylhexyloxyphenol methoxyphenyl triazine (EMT) [1015] (7) Benzotriazoles [1016] a. Drometrizole trisiloxane (DRT) [1017] b. Methylene bis-benzotriazolyl tetramethylbutylphenol (MBP, biscotrizole) [1018] (8) Dibenzoylmethane derivatives [1019] a. 4-tert-Butyl-4-methoxydibenzoylmethane (BM-DBM, avobenzone) [1020] (9) Cinnamates [1021] a. Ethylhexyl methoxycinnamate (OMC) [1022] b. Isoamyl p-methoxycinnamate (IMC, amiloxate) [1023] (10) Camphor derivatives [1024] a. Terephtalydene dicamphor sulfonic acid (PDSA) [1025] b. 3-benzylidene camphor (3BC) [1026] c. Benzylidene camphor sulfonic acid (BCSA) [1027] d. 4-methylbenzylidene camphor (4-MBC) [1028] e. Polyacrylamidomethyl benzylidene camphor (PBC) [1029] (11) Camphor benzalkonium methosulfate (CBM)

[1030] According to the present invention, the at least one inorganic UV-filter (a) is selected from the group of pigments consisting of titanium dioxide (TiO.sub.2) (amorphous or crystallized in rutile and/or anatase form), zinc oxide (ZnO), iron oxide (Fe.sub.2O.sub.3), zirconium oxide (ZrO.sub.2), silicon dioxide (SiO.sub.2), manganese oxide (e.g. MnO), aluminium oxide (Al.sub.2O.sub.3), cerium oxide (Ce.sub.2O.sub.3), barium carbonate (BaCO.sub.3), calcium carbonate (CaCO.sub.3), and mixtures thereof.

[1031] Preferably, the at least one inorganic UV-filter is titanium dioxide, zinc oxide, and mixtures thereof, more preferably the at least one inorganic UV-filter is titanium oxide and/or zinc oxide, and most preferably, the at least one inorganic UV-filter is zinc oxide. ZnO has a broad UVA/UVB absorption curve, while TiO.sub.2 provides better UVB protection.

[1032] According to another variant, the at least one inorganic UV-filter is in form of particles having a weight medium particle size d.sub.50 from 1 nm to 1000 nm, preferably from 3 nm to 800 nm, more preferably from 5 nm to 600 nm, and most preferably from 10 nm to 400 nm.

[1033] The inorganic UV-filters also encompass nano pigments (mean size of the primary particles: generally from 1 nm to 100 nm, preferably from 3 nm to 90 nm, more preferred from 5 nm to 80 nm and most preferred from 10 to 70 nm) of untreated or treated metal oxides such as, for example, nano pigments of titanium dioxide (TiO.sub.2) (amorphous or crystallized in rutile and/or anatase form), zinc oxide (ZnO), iron oxide (Fe.sub.2O.sub.3), zirconium oxide (ZrO.sub.2), silicon dioxide (SiO.sub.2), manganese oxide (e.g. MnO), aluminium oxide (Al.sub.2O.sub.3), cerium oxide (Ce.sub.2O.sub.3), barium carbonate (BaCO.sub.3), calcium carbonate (CaCO.sub.3), or mixtures thereof.

[1034] The treated nano pigments and non-nano pigments are pigments that have undergone one or more surface treatments of chemical, electronic, mechanochemical and/or mechanical nature with compounds, such as amino acids, beeswax, fatty acids, fatty acid esters, fatty alcohols, anionic surfactants, lecithins, sodium, potassium, zinc, iron or aluminium salts of fatty acids, metal (titanium or aluminium) alkoxides, polyethylene, silicones, proteins (collagen or elastin), alkanolamines, silicon oxides, metal oxides, sodium hexametaphosphate, alumina or glycerol, hydrated silica, stearic acid, jojoba esters, or glutamic acid derivates,

[1035] The treated nano pigments and non-nano pigments may more particularly be titanium oxides treated with silica and alumina, alumina and aluminium stearate, alumina and aluminium laurate, aluminium hydroxide, iron oxides and iron stearate, silica, alumina and silicone, sodium hexametaphosphate, octyltrimethoxysilane, alumina and stearic acid, alumina and glycerol, or alumina and silicone or polyhydroxy stearic acid, hydrated silica, jojoba esters, steaoryl glutamic acid, glutamic acid and derivates, trimethoxycaprylylsilane, glycerin, dimethicone, hydrogen dimethicone, simethicone or combinations thereof. Other titanium oxide nano pigments treated with a silicone are preferably TiO.sub.2 treated with octyltrimethylsilane, preferably for which the mean size of the elementary particles is from 25 to 40 nm; TiO.sub.2 treated with a polydimethylsiloxane, preferably for which the mean size of the elementary particles is 21 nm; or TiO.sub.2 treated with a polydimethylhydrogenosiloxane, preferably for which the mean size of the elementary particles is 25 nm.

[1036] The coated zinc oxide nano pigments and zinc oxide non-nano pigments are for example ZnO coated with polymethylhydrogenosiloxane; ZnO dispersions in cyclopolymethylsiloxane/oxyethylenated polydimethylsiloxane, containing 30% or 80% of nano or non-nano zinc oxides coated with silica and polymethylhydrogenosiloxane; ZnO coated with perfluoroalkyl phosphate and copolymer based on perfluoroalkylethyl as a dispersion in cyclopentasiloxane; ZnO coated with dimethoxydiphenylsilanetriethoxycaprylylsilane cross-polymer; ZnO coated with glutamic acid; ZnO coated with octyltriethoxy silane; ZnO coated with dimethicone; ZnO coated with silicone-grafted acrylic polymer, dispersed in cyclodimethylsiloxane; ZnO coated with triethoxycaprylylsilane; ZnO coated with polyhydroxystearic acid; alumina-treated ZnO dispersed in an ethylhexyl methoxycinnamate/PVP-hexadecene/methicone copolymer mixture; ZnO coated with silica and polymethylsilsesquioxane; ZnO dispersed in hydroxystearic acid polycondensate; or ZnO coated with a mixture of steaoryl glutamic acid, jojoba esters, polyhydroxystearic acid, isopropyl titanium triisostearate, hydrogenated olive oil stearyl esters, cetearyl nonanoate, cera alba, dimethicone, dimethoxydiphenylsilanetriethoxycaprylylsilane cross-polymer, octyltriethoxysilane, glutamic acid and sodium stearoyl lactylate.

[1037] Also preferred are particulate UV-filters or inorganic pigments, which can optionally be hydrophobed, such as the oxides of iron (Fe.sub.2O.sub.3), zirconium (ZrO.sub.2), silicon (SiO.sub.2), manganese (e.g. MnO), aluminium (Al.sub.2O.sub.3), cerium (e.g. Ce.sub.2O.sub.3), barium carbonate (BaCO.sub.3), calcium carbonate (CaCO.sub.3), or mixtures thereof.

[1038] The at least one primary organic and/or inorganic UV-filter is selected from the group consisting of Camphor Benzalkonium Methosulfate, Homosalate, Benzophenone-3, Phenylbenzimidazole Sulfonic Acid, Terephthalylidene Dicamphor Sulfonic Acid, Butyl Methoxydibenzoylmethane, Benzylidene Camphor Sulfonic Acid, Octocrylene, Polyacrylamidomethyl Benzylidene Camphor, Ethylhexyl Methoxycinnamate, PEG-25 PABA, Isoamyl p-Methoxycinnamate, Ethylhexyl Triazone, Drometrizole Trisiloxane, Diethylhexyl Butamido Triazone, 4-Methylbenzylidene Camphor, Ethylhexyl Salicylate, Ethylhexyl Dimethyl PABA, Benzophenone-4, Benzophenone-5, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (nano), Disodium Phenyl Dibenzimidazole Tetrasulfonate, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Polysilicone-15, Titanium Dioxide, Titanium Dioxide (nano), Diethylamino Hydroxy benzoyl Hexyl Benzoate, Tris-biphenyl triazine (nano), Zinc Oxide, Zinc Oxide (nano), Phenylene Bis-Diphenyltriazine, Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate, Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine, TEA-Salicylate, Benzophenone-8, PABA, Ethylhexyl Dimethyl PABA, Menthyl Anthranilate, and any mixture thereof.

[1039] The aforesaid primary organic or inorganic UV-filters are used in the compositions either as a single component or preferably in a mixture with two, three, four or more further of said UV-filters as specified above.

[1040] In order to optimize the SPF, i.e. to obtain a high SPF in a range of 6 to 100, preferably in a range of 6 to 70, and to cover a broad UVA and UVB range, the compositions comprises at least two, more preferably at least three, most preferably at least four or even more different primary organic and/or inorganic UV-filters, i.e. in particular organic UV-filters and/or inorganic pigments (UV-filtering pigments). The combination of effective sun protection UV-filters of different categories such as UVA filter, UVB, broadband filter, inorganic pigments provides reliable protection against the different UV rays in the wavelength range of 290 to 400 nm.

[1041] Advantageous the amount of primary organic and/or inorganic sun protection substances (UV-filters) in the compositions according to the present invention is advantageously from 0.01 to 80.0% by weight, preferred from 0.1 to 75.0% by weight, more preferred from 0.5 to 70.0% by weight, and most preferred from 1.0 to 60.0% by weight, based on the total weight of the ready-to-use formulation.

[1042] Besides the group of primary organic and/or inorganic sun protection UV-filters mentioned above, secondary sun protection ingredients of the antioxidant type may also be advantageously used in the compositions according to the present invention in order to further optimize UV protection.

[1043] Secondary sun protection ingredients of the antioxidant type interrupt the photochemical reaction chain which is initiated when UV rays penetrate into the skin.

[1044] Typical examples of secondary sun protection ingredients are amino acids (for example arginine, lysine, glycine, histidine, tyrosine, tryptophane) and derivatives thereof, imidazoles (for example urocanic acid) and derivatives thereof, peptides, such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (for example anserine), carotenoids, carotenes (for example alpha-carotene, beta-carotene, lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, liponic acid and derivatives thereof (for example dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols (for example thioredoxine, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, alpha-linoleyl, cholesteryl and glyceryl esters thereof) and their salts, dilaurylthiodipropionate, distearylthiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (for example butionine sulfoximines, homocysteine sulfoximine, butionine sulfones, penta-, hexa- and hepta-thionine sulfoximine) in very small compatible dosages, also (metal) chelators (for example alpha-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrine), alpha-hydroxy acids (for example citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and derivatives thereof, unsaturated fatty acids and derivatives thereof (for example linoleic acid, oleic acid), folic acid and derivatives thereof, ubiquinone and ubiquinol and derivatives thereof, vitamin C and derivatives thereof (for example ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (for example vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin resin, rutinic acid and derivatives thereof, glycosyl rutin, ferulic acid, furfurylidene glucitol, carnosine, butyl hydroxytoluene, butyl hydroxyanisole, nordihydroguaiac resin acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and derivatives thereof, superoxide dismutase, sinapic acid, sinapoyl malate, sinapate ester derivatives, titanium dioxide (for example dispersions in ethanol), zinc and derivatives thereof (for example ZnO, ZnSO.sub.4), selenium and derivatives thereof (for example selenium methionine), stilbenes and derivatives thereof (for example stilbene oxide, trans-stilbene oxide) and derivatives of these active substances suitable for the purposes of the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids).

[1045] The group of secondary sun protection ingredients also encompasses plant-based extracts that have antioxidative and in general photoprotective properties and interrupt the photochemical reaction chain which is initiated when UV rays penetrate into the skin, and, thus, are effective in preventing skin aging. The plant extracts with UV protection properties are selected from the group consisting of Lignin/Cellulose, Lignin, Lignin Hydrolyzed, Propolis and green propolis, Galanga Extract, macro and micro algae (Porphyra, red algae (Porphyra Umbilicalis), Palmaria palmata, Saccharina latissimi, Corallina pilulifera, Eckloina cava, Sargassum sagamianum, Porphyra rosengurttii, Sargassum siliquastrum, Thalassiosira weissflogii, Green Microalgae (e.g. Interfilum and Klebsormidium), Seaweed (e.g. Padina australis, Euchema, cottonii), Pongamia Glabra Seed Oil, Karanja oil (Millettia pinnata), Rhatania Extrakt (Krameria lappacea), Lichens, Soybean, Caper (Capparis spinosa), Bamboo, Green Coffee oil, Buriti Oil (Mauritia flexuosa), Black Sea Cucumber (Holothuria atra), Cyanobacteria, Fernblock (Polypodium leucotomos), Green Tee, Black Tea (Camellia sinensis), Aloe vera, Walnut, Borage oil, Evening primrose oil, Avocado oil, Tea tree oil, Red Clover (Trifolium pratense L.), Soybean (Glycine max L.), Caper (Capparis spinosa), Almonds, Flame of the forest (Spathodea campanulata), Milk thistle (Silybum marianum L.), Cashew nut shell, Grape, Red Orange, Pomegranate (Punica granatu), Bilberry (Vaccinium myrtillus L.), Bog blueberry (Vaccinium uliginosum L.), Strawberry (Fragaria ananassa), Foti (Polygonum multiflorum Thunb), Turmeric (Curcuma longa L.), Ginseng (Panax ginseng), English ivy (Hedera helix), Broccoli (Brassica oleracea var italica), Tamarind (Tamarindus indica), Opuntia ficus-indica, Coffee, Basil (Ocimum basilicum, Linn.), pomegranate seed oil (Punica granatum), wheat germ oil (Triticum vulgare), blackcurrant seed oil (Ribes nigrum), sesameoil (Sesamum indicum), carrot root (Daucuscarota sativa), raspberry seed oil (Rubus idaeus), traditional medicinal plants from Sri Lanka (Aporosa lindleyana (Euphorbiaceae), Atalantia ceylanica (Rutaceae), Hibiscus furcatus (Malvaceae), Olaxzeylanica (Olacaceae), Ophiorrhiza mungos (Rubiaceae), Argyreia populifolia (Convolvulaceae), Ipomoea mauritiana (Convolvulaceae), Lasia spinosa (Araceae), Leucas zeylanica (Lamiaceae), Plectranthus zeylanicus (Lamiaceae) and Brazil (D. gardneriana seeds, L. microphylla leafs, Amburana cearensis, Aspidosperma cuspa, Aspidosperma pyrifolium, Croton sonderianus, Curatella americana, Dimophandra gardneriana, Lippia microphylla, Luehea paniculata, Sida galheirensis and any mixture thereof.

[1046] Preferably, the plant extracts with UV protection properties are selected from the group consisting of Lignin/Cellulose, Lignin, Lignin Hydrolyzed, Galanga Extract, Porphyra, red algae (Porphyra Umbilicalis), Green Microalgae (e.g. Interfilum and Klebsormidium), Seaweed (e.g. Padina australis, Euchema, cottonii), Pongamia Glabra Seed Oil, Karanja oil (Millettia pinnata), Rhatania Extrakt (Krameria lappacea), Soybean, Bamboo, Buriti Oil (Mauritia flexuosa), Cyanobacteria, Fernblock (Polypodium leucotomos), Green Tee, Black Tea (Camellia sinensis), Evening primrose oil, Cashew nut shell, Pomegranate (Punica granatu), and any mixture thereof.

[1047] Advantageously, the amount of secondary sun protection substances in the food, cosmetic or pharmaceutical preparation or homecare product according to the present invention is advantageously from 0.005 to 5.0% by weight, preferably from 0.01 to 4.0% by weight, most preferred from 0.05 to 3.0% by weight, based on the total weight of the ready-to-use formulation.

[1048] Desquamating agents: The cosmetic or pharmaceutical compositions according to the present invention preferably contain one or more desquamating agents. The expression desquamating agent is understood to mean any compound capable of acting: [1049] either directly on desquamation by promoting exfoliation, such as -hydroxy acids, in particular salicylic acid and its derivatives (including 5-n-octanoylsalicylic acid); -hydroxy acids, such as glycolic, citric, lactic, tartaric, malic or mandelic acids; urea; gentisic acid; oligofucoses; cinnamic acid; extract of Sophora japonica; resveratrol and some derivatives of jasmonic acid; [1050] or on the enzymes involved in the desquamation or the degradation of the corneodesmosomes, glycosidases, stratum corneum chymotryptic enzyme (SCCE) or other proteases (trypsin, chymotrypsin-like). There may be mentioned agents chelating inorganic salts: EDTA; N-acyl-N, N,N-ethylenediaminetriacetic acid; aminosulphonic compounds and in particular (N-2-hydroxyethylpiperazine-N-2-ethane) sulphonic acid (HEPES); derivatives of 2-oxothiazolidine-4-carboxylic acid (procysteine); derivatives of alpha-amino acids of the glycine type (as described in EP-0 852 949, and sodium methylglycine diacetate marketed by BASF under the trade name TRILON M); honey; sugar derivatives such as O-octanoyl-6-D-maltose and N-acetylglucosamine; chestnut extracts such as those marketed by the company SILAB under the name Recoverine, prickly pear extracts such as those marketed under the name Exfolactive by the company SILAB, or Phytosphingosine SLC (phytosphingosine grafted with a salicylic acid) marketed by the company Degussa.

[1051] Desquamating agents suitable for the invention may be chosen in particular from the group comprising sulphonic acids, calcium chelators, -hydroxy acids such as glycolic, citric, lactic, tartaric, malic or mandelic acids; ascorbic acid and its derivatives such as ascorbyl glucoside and magnesium ascorbyl phosphate; nicotinamide; urea; (N-2-hydroxyethylpiperazine-N-2-ethane) sulphonic acid (HEPES), -hydroxy acids such as salicylic acid and its derivatives, retinoids such as retinol and its esters, retinal, retinoic acid and its derivatives, chestnut or prickly pear extracts, in particular marketed by SILAB; reducing compounds such as cysteine or cysteine precursors. Desquamating agents which can be used are also nicotinic acid and its esters and nicotinamide, also called vitamin B3 or vitamin PP, and ascorbic acid and its precursors.

[1052] Anti-dandruff substances: In addition, the compositions according to the present invention can also advantageously be used in combination with one or more anti-dandruff substances, including triclosan, climbazole, octoxyglycerin, Octopirox (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 (1H)-pyridone 2-aminoethanol salt), chitosan, farnesol, glycerol monolaurate, Propanediol Monocaprylate or combinations of said substances, which are used inter alia against dandruff.

[1053] Further suitable anti-dandruff agents are Pirocton Olamin (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridinone monoethanolamine salt), Baypival (Climbazole), Ketoconazol (4-acetyl-1-{4-[2-(2,4-dichlorophenyl) r-2-(1H-imidazol-1-ylmethyl)-1,3-dioxylan-c-4-ylmethoxyphenyl}-piperazine, ketoconazole, elubiol, selenium disulfide, colloidal sulfur, sulfur polyethylene glycol sorbitan monooleate, sulfur ricinol polyethoxylate, sulfur tar distillate, salicylic acid (or in combination with hexachlorophene), undecylenic acid, monoethanolamide sulfosuccinate Na salt, Lamepon UD (protein/undecylenic acid condensate), zinc pyrithione, aluminium pyrithione and magnesium pyrithione/dipyrithione magnesium sulfate.

[1054] (Metal) chelating agents: A combination with one or more (metal) chelating agents can also be advantageous used in the compositions according to the present invention, wherein any metal chelating agents can be used which are suitable or customary in cosmetic or pharmaceutical applications. Preferred (metal) chelating agents include -hydroxy fatty acids, phytic acid, lactoferrin, -hydroxy acids, such as inter alia gluconic acid, glyceric acid, glycolic acid, isocitric acid, citric acid, lactic acid, malic acid, mandelic acid, tartaric acid, as well as humic acids, bile acids, bile extracts, bilirubin, biliverdin or EDTA, EGTA, MGDA (Trisodiumdicarboxymethyl alaninante), and their derivatives. The use of one or more chelating agent(s) improves the stability of the composition according to the present invention.

[1055] Surfactants: The compositions according to the present invention preferably include one or more anionic and/or amphoteric or zwitterionic surfactants. Typical examples encompass: Almondamidopropylamine Oxide, Almondamidopropyl Betaine, Aminopropyl Laurylglutamine, Ammonium C12-15 Alkyl Sulfate, Ammonium C12-16 Alkyl Sulfate, Ammonium Capryleth Sulfate, Ammonium Cocomonoglyceride Sulfate, Ammonium Coco-Sulfate, Ammonium Cocoyl Isethionate, Ammonium Cocoyl Sarcosinate, Ammonium C12-15 Pareth Sulfate, Ammonium C9-10 Perfluoroalkylsulfonate, Ammonium Dinonyl Sulfosuccinate, Ammonium Dodecylbenzenesulfonate, Ammonium Isostearate, Ammonium Laureth-6 Carboxylate, Ammonium Laureth-8 Carboxylate, Ammonium Laureth Sulfate, Ammonium Laureth-5 Sulfate, Ammonium Laureth-7 Sulfate, Ammonium Laureth-9 Sulfate, Ammonium Laureth-12 Sulfate, Ammonium Lauroyl Sarcosinate, Ammonium Lauryl Sulfate, Ammonium Lauryl Sulfosuccinate, Ammonium Myreth Sulfate, Ammonium Myristyl Sulfate, Ammonium Nonoxynol-4 Sulfate, Ammonium Nonoxynol-30 Sulfate, Ammonium Oleate, Ammonium Palm Kernel Sulfate, Ammonium Stearate, Ammonium Tallate, AMPD-Isostearoyl Hydrolyzed Collagen, AMPD-Rosin Hydrolyzed Collagen, AMP-Isostearoyl Hydrolyzed Collagen, AMP-Isostearoyl Hydrolyzed Keratin, AMP-Isostearoyl Hydrolyzed Soy Protein, AMP-Isostearoyl Hydrolyzed Wheat Protein, Apricotamidopropyl Betaine, Arachidic Acid, Arginine Hexyldecyl Phosphate, Avocadamidopropyl Betaine, Avocado Oil Glycereth-8 Esters, Babassu Acid, Babassuamidopropylamine Oxide, Babassuamidopropyl Betaine, Beeswax Acid, Behenamidopropyl Betaine, Behenamine Oxide, Beheneth-25, Beheneth-30, Behenic Acid, Behenyl Betaine, Bis-Butyldimethicone Polyglyceryl-3, Butoxynol-5 Carboxylic Acid, Butoxynol-19 Carboxylic Acid, Butyldimoniumhydroxypropyl Butylglucosides Chloride, Butyldimoniumhydroxypropyl Laurylglucosides Chloride, Butyl Glucoside, Butylglucoside Caprate, Butylglucosides Hydroxypropyltrimonium Chloride, Butyloctanoic Acid, C18-36 Acid, C20-40 Acid, C30-50 Acid, C16-22 Acid Amide MEA, Calcium Dodecylbenzenesulfonate, Calcium Lauroyl Taurate, C9-16 Alkane/Cycloalkane, C10-14 Alkyl Benzenesulfonic Acid, C12-14 Alkyl Diaminoethylglycine HCL, C9-15 Alkyl Phosphate, Candida Bombicola/Glucose/Methyl Rapeseedate Ferment, Canolamidopropyl Betaine, Capric Acid, Caproic Acid, Caproyl Ethyl Glucoside, Capryl/Capramidopropyl Betaine, Capryleth-4 Carboxylic Acid, Capryleth-6 Carboxylic Acid, Capryleth-9 Carboxylic Acid, Caprylic Acid, Capryloyl Collagen Amino Acids, Capryloyl Glycine, Capryloyl Hydrolyzed Collagen, Capryloyl Hydrolyzed Keratin, Capryloyl Keratin Amino Acids, Capryloyl Silk Amino Acids, Caprylyl/Capryl Glucoside, Caprylyl/Capryl Wheat Bran/Straw Glycosides, Caprylyl Glucoside, Caprylyl Glyceryl Ether, Caprylyl Pyrrolidone, Carnitine, Ceteareth-20, Ceteareth-23, Ceteareth-24, Ceteareth-25, Ceteareth-27, Ceteareth-28, Ceteareth-29, Ceteareth-30, Ceteareth-33, Ceteareth-34, Ceteareth-40, Ceteareth-50, Ceteareth-55, Ceteareth-60, Ceteareth-80, Ceteareth-100, Ceteareth-25 Carboxylic Acid, Ceteareth-2 Phosphate, Ceteareth-4 Phosphate, Ceteareth-5 Phosphate, Ceteareth-10 Phosphate, Ceteth-20, Ceteth-23, Ceteth-24, Ceteth-25, Ceteth-30, Ceteth-40, Ceteth-45, Ceteth-150, Ceteth-8 Phosphate, Ceteth-10 Phosphate, Ceteth-20 Phosphate, Cetoleth-22, Cetoleth-24, Cetoleth-25, Cetoleth-30, Cetyl Betaine, Chrysanthemum Sinense Flower Extract, C12-14 Hydroxyalkyl Hydroxyethyl Beta-Alanine, C12-14 Hydroxyalkyl Hydroxyethyl Sarcosine, Cocamidoethyl Betaine, Cocamidopropylamine Oxide, Cocamidopropyl Betainamide MEA Chloride, Cocamidopropyl Betaine, Cocamidopropyl Hydroxysultaine, Cocamine Oxide, Cocaminobutyric Acid, Cocaminopropionic Acid, Coceth-7 Carboxylic Acid, Coceth-4 Glucoside, Cocoamphodipropionic Acid, Cocobetainamido Amphopropionate, Coco-Betaine, Cocodimonium Hydroxypropyl Hydrolyzed Rice Protein, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed Wheat Protein, Coco-Glucoside, Cocoglucosides Hydroxypropyltrimonium Chloride, Coco-Hydroxysultaine, Coco-Morpholine Oxide, Coconut Acid, Coconut Oil Glycereth-8 Esters, Coco/Oleamidopropyl Betaine, Coco-Sultaine, Coco/Sunflower amidopropyl Betaine, Cocoylcholine Methosulfate, Cocoyl Glutamic Acid, Cocoyl Hydrolyzed Collagen, Cocoyl Hydrolyzed Keratin, Cocoyl Hydrolyzed Oat Protein, Cocoyl Hydrolyzed Rice Protein, Cocoyl Hydrolyzed Silk, Cocoyl Hydrolyzed Soy Protein, Cocoyl Hydrolyzed Wheat Protein, Cocoyl Sarcosine, Corn Acid, Cottonseed Acid, Cottonseed Oil Glycereth-8 Esters, C10-16 Pareth-1, C10-16 Pareth-2, C11-13 Pareth-6, C11-13 Pareth-9, C11-13 Pareth-10, C11-15 Pareth-30, C11-15 Pareth-40, C12-13 Pareth-1, C12-13 Pareth-23, C12-14 Pareth-5, C12-14 Pareth-9, C13-15 Pareth-21, C14-15 Pareth-8, C20-22 Pareth-30, C20-40 Pareth-40, C20-40 Pareth-95, C22-24 Pareth-33, C30-50 Pareth-40, C9-11 Pareth-6 Carboxylic Acid, C9-11 Pareth-8 Carboxylic Acid, C11-15 Pareth-7 Carboxylic Acid, C12-13 Pareth-5 Carboxylic Acid, C12-13 Pareth-7 Carboxylic Acid, C12-13 Pareth-8 Carboxylic Acid, C12-13 Pareth-12 Carboxylic Acid, C12-15 Pareth-7 Carboxylic Acid, C12-15 Pareth-8 Carboxylic Acid, C12-15 Pareth-12 Carboxylic Acid, C14-15 Pareth-8 Carboxylic Acid, C6-10 Pareth-4 Phosphate, C12-13 Pareth-2 Phosphate, C12-13 Pareth-10 Phosphate, C12-15 Pareth-6 Phosphate, C12-15 Pareth-8 Phosphate, C12-15 Pareth-10 Phosphate, C12-16 Pareth-6 Phosphate, C4-18 Perfluoroalkylethyl Thiohydroxypropyltrimonium Chloride, Cupuassuamidopropyl Betaine, DEA-C12-13 Alkyl Sulfate, DEA-C12-15 Alkyl Sulfate, DEA-Ceteareth-2 Phosphate, DEA-Cetyl Sulfate, DEA-Cocoamphodipropionate, DEA-C12-13 Pareth-3 Sulfate, DEA-Cyclocarboxypropyloleate, DEA-Dodecylbenzenesulfonate, DEA-Isostearate, DEA-Laureth Sulfate, DEA-Lauryl Sulfate, DEA-Linoleate, DEA-Methyl Myristate Sulfonate, DEA-Myreth Sulfate, DEA-Myristate, DEA-Myristyl Sulfate, DEA-Oleth-5 Phosphate, DEA-Oleth-20 Phosphate, DEA PG-Oleate, Deceth-7 Carboxylic Acid, Deceth-7 Glucoside, Deceth-9 Phosphate, Decylamine Oxide, Decyl Betaine, Decyl Glucoside, Decyltetradeceth-30, Decyltetradecylamine Oxide, Diammonium Lauramido-MEA Sulfosuccinate, Diammonium Lauryl Sulfosuccinate, Diammonium Oleamido PEG-2 Sulfosuccinate, Dibutoxymethane, Di-CI 2-15 Pareth-2 Phosphate, Di-CI 2-15 Pareth-4 Phosphate, Di-CI 2-15 Pareth-6 Phosphate, Di-C12-15 Pareth-8 Phosphate, Di-CI 2-15 Pareth-10 Phosphate, Didodecyl Butanetetracarboxylate, Diethylamine Laureth Sulfate, Diethylhexyl Sodium Sulfosuccinate, Dihydroxyethyl C8-10 Alkoxypropylamine Oxide, Dihydroxyethyl C9-11 Alkoxypropylamine Oxide, Dihydroxyethyl C12-15 Alkoxypropylamine Oxide, Dihydroxyethyl Cocamine Oxide, Dihydroxyethyl Lauramine Oxide, Dihydroxyethyl Stearamine Oxide, Dihydroxyethyl Tallowamine Oxide, Dimethicone PEG-7 Phosphate, Dimethicone PEG-10 Phosphate, Dimethicone PEG/PPG-7/4 Phosphate, Dimethicone PEG/PPG-12/4 Phosphate, Dimethicone/Polyglycerin-3 Crosspolymer, Dimethicone Propyl PG-Betaine, Dimyristyl Phosphate, Dioleoylamidoethyl Hydroxyethylmonium Methosulfate, DIPA-Hydrogenated Cocoate, DIPA-Lanolate, DIPA-Myristate, Dipotassium Capryloyl Glutamate, Dipotassium Lauryl Sulfosuccinate, Dipotassium Undecylenoyl Glutamate, Disodium Babassuamido MEA-Sulfosuccinate, Disodium Caproamphodiacetate, Disodium Caproamphodipropionate, Disodium Capryloamphodiacetate, Disodium Capryloamphodipropionate, Disodium Capryloyl Glutamate, Disodium Cetearyl Sulfosuccinate, Disodium Cetyl Phenyl Ether Disulfonate, Disodium Cetyl Sulfosuccinate, Disodium Cocamido MEA-Sulfosuccinate, Disodium Cocamido MIPA PEG-4 Sulfosuccinate, Disodium Cocamido MIPA-Sulfosuccinate, Disodium Cocamido PEG-3 Sulfosuccinate, Disodium Coceth-3 Sulfosuccinate, Disodium Cocoamphocarboxyethylhydroxypropylsulfonate, Disodium Cocoamphodiacetate, Disodium Cocoamphodipropionate, Disodium Coco-Glucoside Sulfosuccinate, Disodium Coco-Sulfosuccinate, Disodium Cocoyl Butyl Gluceth-10 Sulfosuccinate, Disodium Cocoyl Glutamate, Disodium C12-14 Pareth-1 Sulfosuccinate, Disodium C12-14 Pareth-2 Sulfosuccinate, Disodium C12-15 Pareth Sulfosuccinate, Disodium C12-14 Sec-Pareth-3 Sulfosuccinate, Disodium C12-14 Sec-Pareth-5 Sulfosuccinate, Disodium C12-14 Sec-Pareth-7 Sulfosuccinate, Disodium C12-14 Sec-Pareth-9 Sulfosuccinate, Disodium C12-14 Sec-Pareth-12 Sulfosuccinate, Disodium Deceth-5 Sulfosuccinate, Disodium Deceth-6 Sulfosuccinate, Disodium Decyl Phenyl Ether Disulfonate, Disodium Dihydroxyethyl Sulfosuccinylundecylenate, Disodium Ethylene Dicocamide PEG-15 Disulfate, Disodium Hydrogenated Cottonseed Glyceride Sulfosuccinate, Disodium Hydrogenated Tallow Glutamate, Disodium Hydroxydecyl Sorbitol Citrate, Disodium Isodecyl Sulfosuccinate, Disodium Isostearamido MEA-Sulfosuccinate, Disodium Isostearamido MIPA-Sulfosuccinate, Disodium Isostearoamphodiacetate, Disodium Isostearoamphodipropionate, Disodium Isostearyl Sulfosuccinate, Disodium Laneth-5 Sulfosuccinate, Disodium Lauramido MEA-Sulfosuccinate, Disodium Lauramido MIPA Glycol Sulfosuccinate, Disodium Lauramido PEG-2 Sulfosuccinate, Disodium Lauramido PEG-5 Sulfosuccinate, Disodium Laureth-5 Carboxyamphodiacetate, Disodium Laureth-7 Citrate, Disodium Laureth Sulfosuccinate, Disodium Laureth-6 Sulfosuccinate, Disodium Laureth-9 Sulfosuccinate, Disodium Laureth-12 Sulfosuccinate, Disodium Lauriminobishydroxypropylsulfonate, Disodium Lauriminodiacetate, Disodium Lauriminodipropionate, Disodium Lauriminodipropionate Tocopheryl Phosphates, Disodium Lauroamphodiacetate, Disodium Lauroamphodipropionate, Disodium N-Lauroyl Aspartate, Disodium Lauroyl Glutamate, Disodium Lauryl Phenyl Ether Disulfonate, Disodium Lauryl Sulfosuccinate, Disodium Myristamido MEA-Sulfosuccinate, Disodium Nonoxynol-10 Sulfosuccinate, Disodium Oleamido MEA-Sulfosuccinate, Disodium Oleamido MIPA-Sulfosuccinate, Disodium Oleamido PEG-2 Sulfosuccinate, Disodium Oleoamphodipropionate, Disodium Oleth-3 Sulfosuccinate, Disodium Oleyl Phosphate, Disodium Oleyl Sulfosuccinate, Disodium Palmitamido PEG-2 Sulfosuccinate, Disodium Palmitoleamido PEG-2 Sulfosuccinate, Disodium PEG-4 Cocamido MIPA-Sulfosuccinate, Disodium PEG-12 Dimethicone Sulfosuccinate, Disodium PEG-8 Palm Glycerides Sulfosuccinate, Disodium PPG-2-Isodeceth-7 Carboxyamphodiacetate, Disodium Ricinoleamido MEA-Sulfosuccinate, Disodium Sitostereth-14 Sulfosuccinate, Disodium Soyamphodiacetate, Disodium Stearamido MEA-Sulfosuccinate, Disodium Steariminodipropionate, Disodium Stearoamphodiacetate, Disodium Stearoyl Glutamate, Disodium Stearyl Sulfosuccinamate, Disodium Stearyl Sulfosuccinate, Disodium 2-Sulfolaurate, Disodium 2-Sulfopalmitate, Disodium Tallamido MEA-Sulfosuccinate, Disodium Tallowamido MEA-Sulfosuccinate, Disodium Tallowamphodiacetate, Disodium Tallowiminodipropionate, Disodium Tallow Sulfosuccinamate, Disodium Tridecylsulfosuccinate, Disodium Undecylenamido MEA-Sulfosuccinate, Disodium Undecylenamido PEG-2 Sulfosuccinate, Disodium Undecylenoyl Glutamate, Disodium Wheat Germamido MEA-Sulfosuccinate, Disodium Wheat Germamido PEG-2 Sulfosuccinate, Disodium Wheatgermamphodiacetate, Di-TEA-Cocamide Diacetate, Di-TEA-Oleamido PEG-2 Sulfosuccinate, Di-TEA-Palmitoyl Aspartate, Ditridecyl Sodium Sulfosuccinate, Dodecylbenzene Sulfonic Acid, Erucamidopropyl Hydroxysultaine, Ethylhexeth-3 Carboxylic Acid, Ethyl PEG-15 Cocamine Sulfate, Glyceryl Capryl Ether, Hexyldecanoic Acid, Hydrogenated Coconut Acid, Hydrogenated Laneth-25, Hydrogenated Menhaden Acid, Hydrogenated Palm Acid, Hydrogenated Palm Kernel Amine Oxide, Hydrogenated Tallow Acid, Hydrogenated Tallowamine Oxide, Hydrogenated Tallow Betaine, Hydrogenated Talloweth-25, Hydrogenated Tallowoyl Glutamic Acid, Hydrolyzed Candida Bombicola Extract, Hydroxyceteth-60, Hydroxyethyl Acetomonium PG-Dimethicone, Hydroxyethylbutylamine Laureth Sulfate, Hydroxyethyl Carboxymethyl Cocamidopropylamine, Hydroxyethyl Hydroxypropyl C12-15 Alkoxypropylamine Oxide, Hydroxylauryl/Hydroxymyristyl Betaine, Hydroxystearic Acid, Hydroxysuccinimidyl C10-40 Isoalkyl Acidate, Hydroxysuccinimidyl C21-22 Isoalkyl Acidate, Hydroxysultaines, IPDI/PEG-15 Soyamine Oxide Copolymer, IPDI/PEG-15 Soyethonium Ethosulfate Copolymer, IPDI/PEG-15 Soy Glycinate Copolymer, Isoceteth-30, Isolaureth-4 Phosphate, Isopolyglyceryl-3 Dimethicone, Isopolyglyceryl-3 Dimethiconol, Isopropanolamine Lanolate, Isopropylamine Dodecylbenzenesulfonate, Isostearamidopropylamine Oxide, Isostearamidopropyl Betaine, Isostearamidopropyl Morpholine Oxide, Isosteareth-8, Isosteareth-16, Isosteareth-22, Isosteareth-25, Isosteareth-50, Isostearic Acid, Isostearoyl Hydrolyzed Collagen, Jojoba Oil PEG-150 Esters, Jojoba Wax PEG-80 Esters, Jojoba Wax PEG-120 Esters, Laneth-20, Laneth-25, Laneth-40, Laneth-50, Laneth-60, Laneth-75, Lanolin Acid, Lauramidopropylamine Oxide, Lauramidopropyl Betaine, Lauramidopropyl Hydroxysultaine, Lauramine Oxide, Lauraminopropionic Acid, Laurdimoniumhydroxypropyl Decylglucosides Chloride, Laurdimoniumhydroxypropyl Laurylglucosides Chloride, Laureth-16, Laureth-20, Laureth-21, Laureth-23, Laureth-25, Laureth-30, Laureth-38, Laureth-40, Laureth-3 Carboxylic Acid, Laureth-4 Carboxylic Acid, Laureth-5 Carboxylic Acid, Laureth-6 Carboxylic Acid, Laureth-8 Carboxylic Acid, Laureth-10 Carboxylic Acid, Laureth-11 Carboxylic Acid, Laureth-12 Carboxylic Acid, Laureth-13 Carboxylic Acid, Laureth-14 Carboxylic Acid, Laureth-17 Carboxylic Acid, Laureth-6 Citrate, Laureth-7 Citrate, Laureth-1 Phosphate, Laureth-2 Phosphate, Laureth-3 Phosphate, Laureth-4 Phosphate, Laureth-7 Phosphate, Laureth-8 Phosphate, Laureth-7 Tartrate, Laurie Acid, Laurimino Bispropanediol, Lauriminodipropionic Acid, Lauroamphodipropionic Acid, Lauroyl Beta-Alanine, Lauroyl Collagen Amino Acids, Lauroyl Ethyltrimonium Methosulfate, Lauroyl Hydrolyzed Collagen, Lauroyl Hydrolyzed Elastin, Lauroyl Methyl Glucamide, Lauroyl Sarcosine, Lauroyl Silk Amino Acids, Lauryl Betaine, Lauryl Dimethicone/Polyglycerin-3 Crosspolymer, Lauryldimoniumhydroxypropyl Cocoglucosides Chloride, Lauryl Glucoside, Laurylglucosides Hydroxypropyltrimonium Chloride, Lauryl Glycol Hydroxypropyl Ether, Lauryl Hydroxysultaine, Lauryl Malamide, Lauryl Methylglucamide, Lauryl/Myristyl Glycol Hydroxypropyl Ether, Lauryl/Myristyl Wheat Bran/Straw Glycosides, Lauryl Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Lauryl Pyrrolidone, Lauryl Sultaine, Linoleic Acid, Linolenic Acid, Linseed Acid, Lysine Cocoate, Macadamia Seed Oil Glycereth-8 Esters, Magnesium Coceth Sulfate, Magnesium Coco-Sulfate, Magnesium Isododecylbenzenesulfonate, Magnesium Laureth-11 Carboxylate, Magnesium Laureth Sulfate, Magnesium Laureth-5 Sulfate, Magnesium Laureth-8 Sulfate, Magnesium Laureth-16 Sulfate, Magnesium Laureth-3 Sulfosuccinate, Magnesium Lauryl Hydroxypropyl Sulfonate, Magnesium Lauryl Sulfate, Magnesium Methyl Cocoyl Taurate, Magnesium Myreth Sulfate, Magnesium Oleth Sulfate, Magnesium/TEA-Coco-Sulfate, Manicouagan Clay, MEA-Cocoate, MEA-Laureth-6 Carboxylate, MEA-Laureth Sulfate, MEA-Lauryl Sulfate, MEA PPG-6 Laureth-7 Carboxylate, MEA-PPG-8-Steareth-7 Carboxylate, MEA-Undecylenate, Meroxapol 108, Meroxapol 174, Meroxapol 178, Meroxapol 254, Meroxapol 255, Meroxapol 258, Meroxapol 314, Methoxy PEG-450 Amidoglutaroyl Succinimide, Methoxy PEG-450 Amido Hydroxysuccinimidyl Succinamate, Methoxy PEG-450 Maleimide, Methyl Morpholine Oxide, Milkamidopropyl Amine Oxide, Milkamidopropyl Betaine, Minkamidopropylamine Oxide, Minkamidopropyl Betaine, MIPA C12-15 Pareth Sulfate, MIPA-Dodecylbenzenesulfonate, MIPA-Laureth Sulfate, MIPA-Lauryl Sulfate, Mixed Isopropanolamines Lanolate, Mixed Isopropanolamines Lauryl Sulfate, Mixed Isopropanolamines Myristate, Morpholine Oleate, Morpholine Stearate, Myreth-3 Carboxylic Acid, Myreth-5 Carboxylic Acid, Myristalkonium Chloride, Myristamidopropylamine Oxide, Myristamidopropyl Betaine, Myristamidopropyl Dimethylamine Phosphate, Myristamidopropyl Hydroxysultaine, Myristamidopropyl PG-Dimonium Chloride Phosphate, Myristamine Oxide, Myristaminopropionic Acid, Myristic Acid, Myristoyl Ethyltrimonium Methosulfate, Myristoyl Glutamic Acid, Myristoyl Hydrolyzed Collagen, Myristoyl Sarcosine, Myristyl Betaine, Myristyl/Cetyl Amine Oxide, Myristyldimoniumhydroxypropyl Cocoglucosides Chloride, Myristyl Glucoside, Myristyl Phosphate, Nonoxynol-20, Nonoxynol-23, Nonoxynol-25, Nonoxynol-30, Nonoxynol-35, Nonoxynol-40, Nonoxynol-44, Nonoxynol-50, Nonoxynol-100, Nonoxynol-120, Nonoxynol-5 Carboxylic Acid, Nonoxynol-8 Carboxylic Acid, Nonoxynol-10 Carboxylic Acid, Nonoxynol-3 Phosphate, Nonoxynol-4 Phosphate, Nonoxynol-6 Phosphate, Nonoxynol-9 Phosphate, Nonoxynol-10 Phosphate, Nonyl Nonoxynol-30, Nonyl Nonoxynol-49, Nonyl Nonoxynol-100, Nonyl Nonoxynol-150, Nonyl Nonoxynol-7 Phosphate, Nonyl Nonoxynol-8 Phosphate, Nonyl Nonoxynol-9 Phosphate, Nonyl Nonoxynol-10 Phosphate, Nonyl Nonoxynol-11 Phosphate, Nonyl Nonoxynol-15 Phosphate, Nonyl Nonoxynol-24 Phosphate, Oatamidopropyl Betaine, Octoxynol-16, Octoxynol-25, Octoxynol-30, Octoxynol-33, Octoxynol-40, Octoxynol-70, Octoxynol-20 Carboxylic Acid, Octyldodeceth-20, Octyldodeceth-25, Octyldodeceth-30, Oleamidopropylamine Oxide, Oleamidopropyl Betaine, Oleamidopropyl Hydroxysultaine, Oleamine Oxide, Oleic Acid, Oleoyl Hydrolyzed Collagen, Oleoyl Sarcosine, Oleth-20, Oleth-23, Oleth-24, Oleth-25, Oleth-30, Oleth-35, Oleth-40, Oleth-44, Oleth-50, Oleth-3 Carboxylic Acid, Oleth-6 Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleyl Betaine, Olivamidopropylamine Oxide, Olivamidopropyl Betaine, Olive Acid, Olivoyl Hydrolyzed Wheat Protein, Ophiopogon Extract Stearate, Ozonized Oleth-10, Ozonized PEG-10 Oleate, Ozonized PEG-14 Oleate, Ozonized Polysorbate 80, Palm Acid, Palmamidopropyl Betaine, Palmeth-2 Phosphate, Palmitamidopropylamine Oxide, Palmitamidopropyl Betaine, Palmitamine Oxide, Palmitic Acid, Palmitoyl Collagen Amino Acids, Palmitoyl Glycine, Palmitoyl Hydrolyzed Collagen, Palmitoyl Hydrolyzed Milk Protein, Palmitoyl Hydrolyzed Wheat Protein, Palmitoyl Keratin Amino Acids, Palmitoyl Oligopeptide, Palmitoyl Silk Amino Acids, Palm Kernel Acid, Palm Kernelamidopropyl Betaine, Peach Kernel Oil Glycereth-8 Esters, Peanut Acid, PEG-10 Castor Oil, PEG-40 Castor Oil, PEG-44 Castor Oil, PEG-50 Castor Oil, PEG-54 Castor Oil, PEG-55 Castor Oil, PEG-60 Castor Oil, PEG-80 Castor Oil, PEG-100 Castor Oil, PEG-200 Castor Oil, PEG-11 Cocamide, PEG-6 Cocamide Phosphate, PEG-4 Cocamine, PEG-8 Cocamine, PEG-12 Cocamine, PEG-150 Dibehenate, PEG-90 Diisostearate, PEG-75 Dilaurate, PEG-150 Dilaurate, PEG-75 Dioleate, PEG-150 Dioleate, PEG-75 Distearate, PEG-120 Distearate, PEG-150 Distearate, PEG-175 Distearate, PEG-190 Distearate, PEG-250 Distearate, PEG-30 Glyceryl Cocoate, PEG-40 Glyceryl Cocoate, PEG-78 Glyceryl Cocoate, PEG-80 Glyceryl Cocoate, PEG-30 Glyceryl Isostearate, PEG-40 Glyceryl Isostearate, PEG-50 Glyceryl Isostearate, PEG-60 Glyceryl Isostearate, PEG-90 Glyceryl Isostearate, PEG-23 Glyceryl Laurate, PEG-30 Glyceryl Laurate, PEG-25 Glyceryl Oleate, PEG-30 Glyceryl Oleate, PEG-30 Glyceryl Soyate, PEG-25 Glyceryl Stearate, PEG-30 Glyceryl Stearate, PEG-40 Glyceryl Stearate, PEG-120 Glyceryl Stearate, PEG-200 Glyceryl Stearate, PEG-28 Glyceryl Tallowate, PEG-80 Glyceryl Tallowate, PEG-82 Glyceryl Tallowate, PEG-130 Glyceryl Tallowate, PEG-200 Glyceryl Tallowate, PEG-45 Hydrogenated Castor Oil, PEG-50 Hydrogenated Castor Oil, PEG-54 Hydrogenated Castor Oil, PEG-55 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil, PEG-80 Hydrogenated Castor Oil, PEG-100 Hydrogenated Castor Oil, PEG-200 Hydrogenated Castor Oil, PEG-30 Hydrogenated Lanolin, PEG-70 Hydrogenated Lanolin, PEG-50 Hydrogenated Palmamide, PEG-2 Isostearate, PEG-3 Isostearate, PEG-4 Isostearate, PEG-6 Isostearate, PEG-8 Isostearate, PEG-10 Isostearate, PEG-12 Isostearate, PEG-20 Isostearate, PEG-30 Isostearate, PEG-40 Isostearate, PEG-26 Jojoba Acid, PEG-40 Jojoba Acid, PEG-15 Jojoba Alcohol, PEG-26 Jojoba Alcohol, PEG-40 Jojoba Alcohol, PEG-35 Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-55 Lanolin, PEG-60 Lanolin, PEG-70 Lanolin, PEG-75 Lanolin, PEG-85 Lanolin, PEG-100 Lanolin, PEG-150 Lanolin, PEG-75 Lanolin Oil, PEG-2 Lauramide, PEG-3 Lauramine Oxide, PEG-20 Laurate, PEG-32 Laurate, PEG-75 Laurate, PEG-150 Laurate, PEG-70 Mango Glycerides, PEG-20 Mannitan Laurate, PEG-8 Methyl Ether Dimethicone, PEG-120 Methyl Glucose Dioleate, PEG-80 Methyl Glucose Laurate, PEG-120 Methyl Glucose Trioleate, PEG-4 Montanate, PEG-30 Oleamine, PEG-20 Oleate, PEG-23 Oleate, PEG-32 Oleate, PEG-36 Oleate, PEG-75 Oleate, PEG-150 Oleate, PEG-20 Palmitate, PEG-150 Polyglyceryl-2 Tristearate, PEG/PPG-28/21 Acetate Dimethicone, PEG/PPG-24/18 Butyl Ether Dimethicone, PEG/PPG-3/17 Copolymer, PEG/PPG-5/35 Copolymer, PEG/PPG-8/55 Copolymer, PEG/PPG-10/30 Copolymer, PEG/PPG-10/65 Copolymer, PEG/PPG-12/35 Copolymer, PEG/PPG-16/17 Copolymer, PEG/PPG-20/9 Copolymer, PEG/PPG-20/20 Copolymer, PEG/PPG-20/60 Copolymer, PEG/PPG-20/65 Copolymer, PEG/PPG-22/25 Copolymer, PEG/PPG-28/30 Copolymer, PEG/PPG-30-35 Copolymer, PEG/PPG-30/55 Copolymer, PEG/PPG-35/40 Copolymer, PEG/PPG-50/40 Copolymer, PEG/PPG-150/35 Copolymer, PEG/PPG-160/30 Copolymer, PEG/PPG-190/60 Copolymer, PEG/PPG-200/40 Copolymer, PEG/PPG-300/55 Copolymer, PEG/PPG-20/22 Methyl Ether Dimethicone, PEG-26-PPG-30 Phosphate, PEG/PPG-4/2 Propylheptyl Ether, PEG/PPG-6/2 Propylheptyl Ether, PEG-7/PPG-2 Propylheptyl Ether, PEG/PPG-8/2 Propylheptyl Ether, PEG/PPG-10/2 Propylheptyl Ether, PEG/PPG-14/2 Propylheptyl Ether, PEG/PPG-40/2 Propylheptyl Ether, PEG/PPG-10/2 Ricinoleate, PEG/PPG-32/3 Ricinoleate, PEG-55 Propylene Glycol Oleate, PEG-25 Propylene Glycol Stearate, PEG-75 Propylene Glycol Stearate, PEG-120 Propylene Glycol Stearate, PEG-5 Rapeseed Sterol, PEG-10 Rapeseed Sterol, PEG-40 Ricinoleamide, PEG-75 Shea Butter Glycerides, PEG-75 Shorea Butter Glycerides, PEG-20 Sorbitan Cocoate, PEG-20 Sorbitan Isostearate, PEG-40 Sorbitan Lanolate, PEG-75 Sorbitan Lanolate, PEG-10 Sorbitan Laurate, PEG-40 Sorbitan Laurate, PEG-44 Sorbitan Laurate, PEG-75 Sorbitan Laurate, PEG-80 Sorbitan Laurate, PEG-20 Sorbitan Oleate, PEG-80 Sorbitan Palmitate, PEG-40 Sorbitan Stearate, PEG-60 Sorbitan Stearate, PEG-160 Sorbitan Triisostearate, PEG-40 Soy Sterol, PEG-2 Stearamide Carboxylic Acid, PEG-9 Stearamide Carboxylic Acid, PEG-20 Stearate, PEG-23 Stearate, PEG-25 Stearate, PEG-30 Stearate, PEG-32 Stearate, PEG-35 Stearate, PEG-36 Stearate, PEG-40 Stearate, PEG-45 Stearate, PEG-50 Stearate, PEG-55 Stearate, PEG-75 Stearate, PEG-90 Stearate, PEG-100 Stearate, PEG-120 Stearate, PEG-150 Stearate, PEG-45 Stearate Phosphate, PEG-20 Tallate, PEG-50 Tallow Amide, PEG-2 Tallowamide DEA, PEG-20 Tallowate, PEG-66 Trihydroxystearin, PEG-200 Trihydroxystearin, PEG-60 Tsubakiate Glycerides, Pelargonic Acid, Pentadoxynol-200, Pheneth-6 Phosphate, Poloxamer 105, Poloxamer 108, Poloxamer 182, Poloxamer 183, Poloxamer 184, Poloxamer 188, Poloxamer 217, Poloxamer 234, Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 288, Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamine 908, Poloxamine 1508, Polydimethylsiloxy PEG/PPG-24/19 Butyl Ether Silsesquioxane, Polydimethylsiloxy PPG-13 Butyl Ether Silsesquioxane, Polyglyceryl-6 Caprate, Polyglyceryl-10 Dilaurate, Polyglyceryl-20 Heptacaprylate, Polyglyceryl-20 Hexacaprylate, Polyglyceryl-2 Lauryl Ether, Polyglyceryl-10 Lauryl Ether, Polyglyceryl-20 Octaisononanoate, Polyglyceryl-6 Pentacaprylate, Polyglyceryl-10 Pentacaprylate, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Polyglyceryl-6 Tetracaprylate, Polyglyceryl-10 Tetralaurate, Polyglyceryl-6 Tricaprylate, Polyglyceryl-10 Trilaurate, Polyquaternium-77, Polyquaternium-78, Polyquaternium-79, Polyquaternium-80, Polyquaternium-81, Polyquaternium-82, Pomaderris Kumerahou Flower/Leaf Extract, Poria Cocos Extract, Potassium Abietoyl Hydrolyzed Collagen, Potassium Babassuate, Potassium Behenate, Potassium C9-15 Alkyl Phosphate, Potassium C11-15 Alkyl Phosphate, Potassium C12-13 Alkyl Phosphate, Potassium C12-14 Alkyl Phosphate, Potassium Caprate, Potassium Capryloyl Glutamate, Potassium Capryloyl Hydrolyzed Rice Protein, Potassium Castorate, Potassium Cocoate, Potassium Cocoyl Glutamate, Potassium Cocoyl Glycinate, Potassium Cocoyl Hydrolyzed Casein, Potassium Cocoyl Hydrolyzed Collagen, Potassium Cocoyl Hydrolyzed Corn Protein, Potassium Cocoyl Hydrolyzed Keratin, Potassium Cocoyl Hydrolyzed Oat Protein, Potassium Cocoyl Hydrolyzed Potato Protein, Potassium Cocoyl Hydrolyzed Rice Bran Protein, Potassium Cocoyl Hydrolyzed Rice Protein, Potassium Cocoyl Hydrolyzed Silk, Potassium Cocoyl Hydrolyzed Soy Protein, Potassium Cocoyl Hydrolyzed Wheat Protein, Potassium Cocoyl Hydrolyzed Yeast Protein, Potassium Cocoyl PCA, Potassium Cocoyl Sarcosinate, Potassium Cocoyl Taurate, Potassium Cornate, Potassium Cyclocarboxypropyloleate, Potassium Dihydroxyethyl Cocamine Oxide Phosphate, Potassium Dimethicone PEG-7 Phosphate, Potassium Dodecylbenzenesulfonate, Potassium Hempseedate, Potassium Hydrogenated Cocoate, Potassium Hydrogenated Palmate, Potassium Hydrogenated Tallowate, Potassium Hydroxystearate, Potassium Isostearate, Potassium Lanolate, Potassium Laurate, Potassium Laureth-3 Carboxylate, Potassium Laureth-4 Carboxylate, Potassium Laureth-5 Carboxylate, Potassium Laureth-6 Carboxylate, Potassium Laureth-10 Carboxylate, Potassium Laureth Phosphate, Potassium Lauroyl Collagen Amino Acids, Potassium Lauroyl Glutamate, Potassium Lauroyl Hydrolyzed Collagen, Potassium Lauroyl Hydrolyzed Pea Protein, Potassium Lauroyl Hydrolyzed Soy Protein, Potassium Lauroyl PCA, Potassium Lauroyl Pea Amino Acids, Potassium Lauroyl Sarcosinate, Potassium Lauroyl Silk Amino Acids, Potassium Lauroyl Wheat Amino Acids, Potassium Lauryl Phosphate, Potassium Lauryl Sulfate, Potassium Linoleate, Potassium Metaphosphate, Potassium Methyl Cocoyl Taurate, Potassium Myristate, Potassium Myristoyl Glutamate, Potassium Myristoyl Hydrolyzed Collagen, Potassium Octoxynol-12 Phosphate, Potassium Oleate, Potassium Oleoyl Hydrolyzed Collagen, Potassium Olivate, Potassium Olivoyl Hydrolyzed Oat Protein, Potassium Olivoyl Hydrolyzed Wheat Protein, Potassium Olivoyl/Lauroyl Wheat Amino Acids, Potassium Olivoyl PCA, Potassium Palmate, Potassium Palmitate, Potassium Palmitoyl Hydrolyzed Corn Protein, Potassium Palmitoyl Hydrolyzed Oat Protein, Potassium Palmitoyl Hydrolyzed Rice Protein, Potassium Palmitoyl Hydrolyzed Sweet Almond Protein, Potassium Palmitoyl Hydrolyzed Wheat Protein, Potassium Palm Kernelate, Potassium Peanutate, Potassium Rapeseedate, Potassium Ricinoleate, Potassium Safflowerate, Potassium Soyate, Potassium Stearate, Potassium Stearoyl Hydrolyzed Collagen, Potassium Tallate, Potassium Tallowate, Potassium Taurate, Potassium Taurine Laurate, Potassium Trideceth-3 Carboxylate, Potassium Trideceth-4 Carboxylate, Potassium Trideceth-7 Carboxylate, Potassium Trideceth-15 Carboxylate, Potassium Trideceth-19 Carboxylate, Potassium Trideceth-6 Phosphate, Potassium Trideceth-7 Phosphate, Potassium Tsubakiate, Potassium Undecylenate, Potassium Undecylenoyl Hydrolyzed Collagen, Potassium Undecylenoyl Hydrolyzed Rice Protein, PPG-30-Buteth-30, PPG-36-Buteth-36, PPG-38-Buteth-37, PPG-30-Capryleth-4 Phosphate, PPG-10 Cetyl Ether Phosphate, PPG-2 C9-11 Pareth-8, PPG-1-Deceth-5, PPG-3-Deceth-2 Carboxylic Acid, PPG-30 Ethylhexeth-4 Phosphate, PPG-20-Glycereth-30, PPG-2 Hydroxyethyl Coco/Isostearamide, PPG-2-Isodeceth-8, PPG-2-Isodeceth-10, PPG-2-Isodeceth-18, PPG-2-Isodeceth-25, PPG-4-Isodeceth-10, Propyltrimonium Hydrolyzed Collagen, Quaternium-24, Quaternium-52, Quaternium-87, Rapeseed Acid, Rice Bran Acid, Rice Oil Glycereth-8 Esters, Ricinoleamidopropyl Betaine, Ricinoleic Acid, Ricinoleth-40, Safflower Acid, Sapindus Oahuensis Fruit Extract, Saponaria Officinalis Root Powder, Saponins, Sekken-K, Sekken-Na/K, Sekken Soji, Sekken Soji-K, Sesame Oil Glycereth-8 Esters, Sesamidopropylamine Oxide, Sesamidopropyl Betaine, Shea Butteramidopropyl Betaine, Shea Butter Glycereth-8 Esters, Sodium Arachidate, Sodium Arganampohoacetate, Sodium Astrocaryum Murumuruate, Sodium Avocadoate, Sodium Babassuamphoacetate, Sodium Babassuate, Sodium Babassu Sulfate, Sodium Behenate, Sodium Bisglycol Ricinosulfosuccinate, Sodium Bis-Hydroxyethylglycinate Coco-Glucosides Crosspolymer, Sodium Bis-Hydroxyethylglycinate Lauryl-Glucosides Crosspolymer, Sodium Borageamidopropyl PG-Dimonium Chloride Phosphate, Sodium Butoxynol-12 Sulfate, Sodium Butylglucosides Hydroxypropyl Phosphate, Sodium C13-17 Alkane Sulfonate, Sodium C14-18 Alkane Sulfonate, Sodium C12-15 Alkoxypropyl Iminodipropionate, Sodium C10-16 Alkyl Sulfate, Sodium C11-15 Alkyl Sulfate, Sodium C12-13 Alkyl Sulfate, Sodium C12-15 Alkyl Sulfate, Sodium C12-18 Alkyl Sulfate, Sodium C16-20 Alkyl Sulfate, Sodium C9-22 Alkyl Sec Sulfonate, Sodium C14-17 Alkyl Sec Sulfonate, Sodium Caprate, Sodium Caproamphoacetate, Sodium Caproamphohydroxypropylsulfonate, Sodium Caproamphopropionate, Sodium Caproyl Methyltaurate, Sodium Caprylate, Sodium Capryleth-2 Carboxylate, Sodium Capryleth-9 Carboxylate, Sodium Capryloamphoacetate, Sodium Capryloamphohydroxypropylsulfonate, Sodium Capryloamphopropionate, Sodium Capryloyl Glutamate, Sodium Capryloyl Hydrolyzed Wheat Protein, Sodium Caprylyl PG-Sulfonate, Sodium Caprylyl Sulfonate, Sodium Castorate, Sodium Ceteareth-13 Carboxylate, Sodium Cetearyl Sulfate, Sodium Ceteth-13 Carboxylate, Sodium Cetyl Sulfate, Sodium Cocamidopropyl PG-Dimonium Chloride Phosphate, Sodium Cocaminopropionate, Sodium Coceth Sulfate, Sodium Coceth-30 Sulfate, Sodium Cocoabutteramphoacetate, Sodium Cocoa Butterate, Sodium Cocoamphoacetate, Sodium Cocoamphohydroxypropylsulfonate, Sodium Cocoamphopropionate, Sodium Cocoate, Sodium Coco/Babassu/Andiroba Sulfate, Sodium Coco/Babassu Sulfate, Sodium Cocoglucosides Hydroxypropyl Phosphate, Sodium Cocoglucosides Hydroxypropylsulfonate, Sodium Coco-Glucoside Tartrate, Sodium Cocoglyceryl Ether Sulfonate, Sodium Coco/Hydrogenated Tallow Sulfate, Sodium Cocoiminodiacetate, Sodium Cocomonoglyceride Sulfate, Sodium Cocomonoglyceride Sulfonate, Sodium Coco PG-Dimonium Chloride Phosphate, Sodium Coco-Sulfate, Sodium Coco Sulfoacetate, Sodium Cocoyl Alaninate, Sodium Cocoyl Amino Acids, Sodium Cocoyl Collagen Amino Acids, Sodium Cocoyl Glutamate, Sodium Cocoyl Glutaminate, Sodium Cocoyl Glycinate, Sodium Cocoyl/Hydrogenated Tallow Glutamate, Sodium Cocoyl Hydrolyzed Collagen, Sodium Cocoyl Hydrolyzed Keratin, Sodium Cocoyl Hydrolyzed Rice Protein, Sodium Cocoyl Hydrolyzed Silk, Sodium Cocoyl Hydrolyzed Soy Protein, Sodium Cocoyl Hydrolyzed Sweet Almond Protein, Sodium Cocoyl Hydrolyzed Wheat Protein, Sodium Cocoyl Hydrolyzed Wheat Protein Glutamate, Sodium Cocoyl Isethionate, Sodium Cocoyl Methylaminopropionate, Sodium Cocoyl Oat Amino Acids, Sodium Cocoyl/Palmoyl/Sunfloweroyl Glutamate, Sodium Cocoyl Proline, Sodium Cocoyl Sarcosinate, Sodium Cocoyl Taurate, Sodium Cocoyl Threoninate, Sodium Cocoyl Wheat Amino Acids, Sodium C12-14 Olefin Sulfonate, Sodium C14-16 Olefin Sulfonate, Sodium C14-18 Olefin Sulfonate, Sodium C16-18 Olefin Sulfonate, Sodium Cornamphopropionate, Sodium Cottonseedamphoacetate, Sodium C13-15 Pareth-8 Butyl Phosphate, Sodium C9-11 Pareth-6 Carboxylate, Sodium C11-15 Pareth-7 Carboxylate, Sodium C12-13 Pareth-5 Carboxylate, Sodium C12-13 Pareth-8 Carboxylate, Sodium C12-13 Pareth-12 Carboxylate, Sodium C12-15 Pareth-6 Carboxylate, Sodium C12-15 Pareth-7 Carboxylate, Sodium C12-15 Pareth-8 Carboxylate, Sodium C14-15 Pareth-8 Carboxylate, Sodium C12-14 Sec-Pareth-8 Carboxylate, Sodium C14-15 Pareth-PG Sulfonate, Sodium C12-13 Pareth-2 Phosphate, Sodium C13-15 Pareth-8 Phosphate, Sodium C9-15 Pareth-3 Sulfate, Sodium C10-15 Pareth Sulfate, Sodium C10-16 Pareth-2 Sulfate, Sodium C12-13 Pareth Sulfate, Sodium C12-15 Pareth Sulfate, Sodium C12-15 Pareth-3 Sulfate, Sodium C13-15 Pareth-3 Sulfate, Sodium C12-14 Sec-Pareth-3 Sulfate, Sodium C12-15 Pareth-3 Sulfonate, Sodium C12-15 Pareth-7 Sulfonate, Sodium C12-15 Pareth-15 Sulfonate, Sodium Deceth-2 Carboxylate, Sodium Deceth Sulfate, Sodium Decylbenzenesulfonate, Sodium Decylglucosides Hydroxypropyl Phosphate, Sodium Decylglucosides Hydroxypropylsulfonate, Sodium Dilaureth-7 Citrate, Sodium Dilaureth-10 Phosphate, Sodium Dilinoleamidopropyl PG-Dimonium Chloride Phosphate, Sodium Dilinoleate, Sodium Dioleth-8 Phosphate, Sodium Dodecylbenzenesulfonate, Sodium Ethyl 2-Sulfolaurate, Sodium Glyceryl Oleate Phosphate, Sodium Grapeseedamidopropyl PG-Dimonium Chloride Phosphate, Sodium Grapeseedamphoacetate, Sodium Grapeseedate, Sodium Hempseedamphoacetate, Sodium Hexeth-4 Carboxylate, Sodium Hydrogenated Cocoate, Sodium Hydrogenated Cocoyl Methyl Isethionate, Sodium Hydrogenated Palmate, Sodium Hydrogenated Tallowate, Sodium Hydrogenated Tallowoyl Glutamate, Sodium Hydroxylauryldimonium Ethyl Phosphate, Sodium Hydroxypropyl Palm Kernelate Sulfonate, Sodium Hydroxypropylphosphate Decylglucoside Crosspolymer, Sodium Hydroxypropylphosphate Laurylglucoside Crosspolymer, Sodium Hydroxypropylsulfonate Cocoglucoside Crosspolymer, Sodium Hydroxypropylsulfonate Decylglucoside Crosspolymer, Sodium Hydroxypropylsulfonate Laurylglucoside Crosspolymer, Sodium Hydroxystearate, Sodium Isostearate, Sodium Isosteareth-6 Carboxylate, Sodium Isosteareth-11 Carboxylate, Sodium Isostearoamphoacetate, Sodium Isostearoamphopropionate, Sodium N-Isostearoyl Methyltaurate, Sodium Laneth Sulfate, Sodium Lanolate, Sodium Lardate, Sodium Lauramido Diacetate, Sodium Lauraminopropionate, Sodium Laurate, Sodium Laureth-3 Carboxylate, Sodium Laureth-4 Carboxylate, Sodium Laureth-5 Carboxylate, Sodium Laureth-6 Carboxylate, Sodium Laureth-8 Carboxylate, Sodium Laureth-11 Carboxylate, Sodium Laureth-12 Carboxylate, Sodium Laureth-13 Carboxylate, Sodium Laureth-14 Carboxylate, Sodium Laureth-16 Carboxylate, Sodium Laureth-17 Carboxylate, Sodium Laureth Sulfate, Sodium Laureth-5 Sulfate, Sodium Laureth-7 Sulfate, Sodium Laureth-8 Sulfate, Sodium Laureth-12 Sulfate, Sodium Laureth-40 Sulfate, Sodium Laureth-7 Tartrate, Sodium Lauriminodipropionate, Sodium Lauroamphoacetate, Sodium Lauroamphohydroxypropylsulfonate, Sodium Lauroampho PG-Acetate Phosphate, Sodium Lauroamphopropionate, Sodium Lauroyl Aspartate, Sodium Lauroyl Collagen Amino Acids, Sodium Lauroyl Glycine Propionate, Sodium Lauroyl Hydrolyzed Collagen, Sodium Lauroyl Hydrolyzed Silk, Sodium Lauroyl Hydroxypropyl Sulfonate, Sodium Lauroyl Isethionate, Sodium Lauroyl Methylaminopropionate, Sodium Lauroyl Methyl Isethionate, Sodium Lauroyl Millet Amino Acids, Sodium Lauroyl/Myristoyl Aspartate, Sodium Lauroyl Oat Amino Acids, Sodium Lauroyl Sarcosinate, Sodium Lauroyl Silk Amino Acids, Sodium Lauroyl Taurate, Sodium Lauroyl Wheat Amino Acids, Sodium Lauryl Diethylenediaminoglycinate, Sodium Lauryl Glucose Carboxylate, Sodium Laurylglucosides Hydroxypropyl Phosphate, Sodium Laurylglucosides Hydroxypropylsulfonate, Sodium Lauryl Glycol Carboxylate, Sodium Lauryl Hydroxyacetamide Sulfate, Sodium Lauryl Phosphate, Sodium Lauryl Sulfate, Sodium Lauryl Sulfoacetate, Sodium Linoleate, Sodium Macadamiaseedate, Sodium Mangoamphoacetate, Sodium Mangoseedate, Sodium/MEA Laureth-2 Sulfosuccinate, Sodium Methoxy PPG-2 Acetate, Sodium Methyl Cocoyl Taurate, Sodium Methyl Lauroyl Taurate, Sodium Methyl Myristoyl Taurate, Sodium Methyl Oleoyl Taurate, Sodium Methyl Palmitoyl Taurate, Sodium Methyl Stearoyl Taurate, Sodium Methyl 2-Sulfolaurate, Sodium Methyl 2-Sulfopalmitate, Sodium Methyltaurate Isopalmitamide, Sodium Methyltaurine Cocoyl Methyltaurate, Sodium Myreth Sulfate, Sodium Myristate, Sodium Myristoamphoacetate, Sodium Myristoyl Glutamate, Sodium Myristoyl Hydrolyzed Collagen, Sodium Myristoyl Isethionate, Sodium Myristoyl Sarcosinate, Sodium Myristyl Sulfate, Sodium Nonoxynol-6 Phosphate, Sodium Nonoxynol-9 Phosphate, Sodium Nonoxynol-1 Sulfate, Sodium Nonoxynol-3 Sulfate, Sodium Nonoxynol-4 Sulfate, Sodium Nonoxynol-6 Sulfate, Sodium Nonoxynol-8 Sulfate, Sodium Nonoxynol-10 Sulfate, Sodium Nonoxynol-25 Sulfate, Sodium Octoxynol-2 Ethane Sulfonate, Sodium Octoxynol-2 Sulfate, Sodium Octoxynol-6 Sulfate, Sodium Octoxynol-9 Sulfate, Sodium Oleate, Sodium Oleoamphoacetate, Sodium Oleoamphohydroxypropylsulfonate, Sodium Oleoamphopropionate, Sodium Oleoyl Hydrolyzed Collagen, Sodium Oleoyl Isethionate, Sodium Oleth Sulfate, Sodium Oleyl Methyl Isethionate, Sodium Oleyl Sulfate, Sodium Olivamphoacetate, Sodium Olivate, Sodium Olivoyl Glutamate, Sodium Palmamphoacetate, Sodium Palmate, Sodium Palm Glyceride Sulfonate, Sodium Palmitate, Sodium Palmitoyl Hydrolyzed Collagen, Sodium Palmitoyl Hydrolyzed Wheat Protein, Sodium Palmitoyl Sarcosinate, Sodium Palm Kernelate, Sodium Palm Kerneloyl Isethionate, Sodium Palmoyl Glutamate, Sodium Passiflora Edulis Seedate, Sodium Peanutamphoacetate, Sodium Peanutate, Sodium PEG-6 Cocamide Carboxylate, Sodium PEG-8 Cocamide Carboxylate, Sodium PEG-4 Cocamide Sulfate, Sodium PEG-3 Lauramide Carboxylate, Sodium PEG-4 Lauramide Carboxylate, Sodium PEG-8 Palm Glycerides Carboxylate, Sodium Pentaerythrityl Hydroxypropyl Iminodiacetate Dendrimer, Sodium Propoxy PPG-2 Acetate, Sodium Rapeseedate, Sodium Ricebranamphoacetate, Sodium Ricinoleate, Sodium Ricinoleoamphoacetate, Sodium Rose Hipsamphoacetate, Sodium Rosinate, Sodium Safflowerate, Sodium Saffloweroyl Hydrolyzed Soy Protein, Sodium Sesameseedate, Sodium Sesamphoacetate, Sodium Sheabutteramphoacetate, Sodium Soyate, Sodium Soy Hydrolyzed Collagen, Sodium Stearate, Sodium Stearoamphoacetate, Sodium Stearoamphohydroxypropylsulfonate, Sodium Stearoamphopropionate, Sodium Stearoyl Casein, Sodium Stearoyl Glutamate, Sodium Stearoyl Hyaluronate, Sodium Stearoyl Hydrolyzed Collagen, Sodium Stearoyl Hydrolyzed Corn Protein, Sodium Stearoyl Hydrolyzed Silk, Sodium Stearoyl Hydrolyzed Soy Protein, Sodium Stearoyl Hydrolyzed Wheat Protein, Sodium Stearoyl Lactalbumin, Sodium Stearoyl Methyl Isethionate, Sodium Stearoyl Oat Protein, Sodium Stearoyl Pea Protein, Sodium Stearoyl Soy Protein, Sodium Stearyl Dimethyl Glycine, Sodium Stearyl Sulfate, Sodium Sunflowerseedamphoacetate, Sodium Surfactin, Sodium Sweetalmondamphoacetate, Sodium Sweet Almondate, Sodium Tallamphopropionate, Sodium Tallate, Sodium Tallowamphoacetate, Sodium Tallowate, Sodium Tallow Sulfate, Sodium Tamanuseedate, Sodium Taurate, Sodium Taurine Cocoyl Methyltaurate, Sodium Taurine Laurate, Sodium/TEA-Lauroyl Collagen Amino Acids, Sodium/TEA-Lauroyl Hydrolyzed Collagen, Sodium/TEA-Lauroyl Hydrolyzed Keratin, Sodium/TEA-Lauroyl Keratin Amino Acids, Sodium/TEA-Undecylenoyl Collagen Amino Acids, Sodium/TEA-Undecylenoyl Hydrolyzed Collagen, Sodium/TEA-Undecylenoyl Hydrolyzed Corn Protein, Sodium/TEA-Undecylenoyl Hydrolyzed Soy Protein, Sodium/TEA-Undecylenoyl Hydrolyzed Wheat Protein, Sodium Theobroma Grandiflorum Seedate, Sodium Trideceth-3 Carboxylate, Sodium Trideceth-4 Carboxylate, Sodium Trideceth-6 Carboxylate, Sodium Trideceth-7 Carboxylate, Sodium Trideceth-8 Carboxylate, Sodium Trideceth-12 Carboxylate, Sodium Trideceth-15 Carboxylate, Sodium Trideceth-19 Carboxylate, Sodium Trideceth Sulfate, Sodium Tridecylbenzenesulfonate, Sodium Tridecyl Sulfate, Sodium Trimethylolpropane Hydroxypropyl Iminodiacetate Dendrimer, Sodium Undeceth-5 Carboxylate, Sodium Undecylenate, Sodium Undecylenoamphoacetate, Sodium Undecylenoamphopropionate, Sodium Undecylenoyl Glutamate, Sodium Wheat Germamphoacetate, Sorbeth-160 Tristearate, Soy Acid, Soyamidopropylamine Oxide, Soyamidopropyl Betaine, Soybean Oil Glycereth-8 Esters, Stearamidopropylamine Oxide, Stearamidopropyl Betaine, Stearamine Oxide, Steareth-15, Steareth-16, Steareth-20, Steareth-21, Steareth-25, Steareth-27, Steareth-30, Steareth-40, Steareth-50, Steareth-80, Steareth-100, Steareth-2 Phosphate, Steareth-3 Phosphate, Stearic Acid, Stearoxypropyltrimonium Chloride, Stearoyl Glutamic Acid, Stearoyl Sarcosine, Stearyl Betaine, Stearyldimoniumhydroxypropyl Butylglucosides Chloride, Stearyldimoniumhydroxypropyl Decylglucosides Chloride, Stearyldimoniumhydroxypropyl Laurylglucosides Chloride, Sulfated Castor Oil, Sulfated Coconut Oil, Sulfated Glyceryl Oleate, Sulfated Olive Oil, Sulfated Peanut Oil, Sunfloweramide MEA, Sunflower Seed Acid, Sunflowerseedamidopropyl Hydroxyethyldimonium Chloride, Sunflower Seed Oil Glycereth-8 Esters, Tall Oil Acid, Tallow Acid, Tallowamidopropylamine Oxide, Tallowamidopropyl Betaine, Tallowamidopropyl Hydroxysultaine, Tallowamine Oxide, Tallow Betaine, Tallow Dihydroxyethyl Betaine, Tallowoyl Ethyl Glucoside, TEA-Abietoyl Hydrolyzed Collagen, TEA-C12-14 Alkyl Phosphate, TEA-C10-15 Alkyl Sulfate, TEA-C11-15 Alkyl Sulfate, TEA-C12-13 Alkyl Sulfate, TEA-C12-14 Alkyl Sulfate, TEA-C12-15 Alkyl Sulfate, TEA C14-17 Alkyl Sec Sulfonate, TEA-Canolate, TEA-Cocamide Diacetate, TEA-Cocoate, TEA-Coco-Sulfate, TEA-Cocoyl Alaninate, TEA-Cocoyl Glutamate, TEA-Cocoyl Glutaminate, TEA-Cocoyl Glycinate, TEA-Cocoyl Hydrolyzed Collagen, TEA-Cocoyl Hydrolyzed Soy Protein, TEA-Cocoyl Sarcosinate, TEA-Dimethicone PEG-7 Phosphate, TEA-Dodecylbenzenesulfonate, TEA-Hydrogenated Cocoate, TEA-Hydrogenated Tallowoyl Glutamate, TEA-Isostearate, TEA-Isostearoyl Hydrolyzed Collagen, TEA-Lauraminopropionate, TEA-Laurate, TEA-Laurate/Myristate, TEA-Laureth Sulfate, TEA-Lauroyl Collagen Amino Acids, TEA-Lauroyl Glutamate, TEA-Lauroyl Hydrolyzed Collagen, TEA-Lauroyl Keratin Amino Acids, TEA-Lauroyl Methylaminopropionate, TEA-Lauroyl/Myristoyl Aspartate, TEA-Lauroyl Sarcosinate, TEA-Lauryl Phosphate, TEA-Lauryl Sulfate, TEA-Myristaminopropionate, TEA-Myristate, TEA-Myristoyl Hydrolyzed Collagen, TEA-Oleate, TEA-Oleoyl Hydrolyzed Collagen, TEA-Oleoyl Sarcosinate, TEA-Oleyl Sulfate, TEA-Palmitate, TEA-Palm Kernel Sarcosinate, TEA-PEG-3 Cocamide Sulfate, TEA-Rosinate, TEA-Stearate, TEA-Tallate, TEA-Tridecylbenzenesulfonate, TEA-Undecylenate, TEA-Undecylenoyl Hydrolyzed Collagen, Tetramethyl Decynediol, Tetrasodium Dicarboxyethyl Stearyl Sulfosuccinamate, TIPA-Laureth Sulfate, TIPA-Lauryl Sulfate, TIPA-Myristate, TIPA-Stearate, Tocopheryl Phosphate, Trehalose Undecylenoate, TM-C12-15 Pareth-2 Phosphate, TM-C12-15 Pareth-6 Phosphate, TM-C12-15 Pareth-8 Phosphate, TM-C12-15 Pareth-10 Phosphate, Trideceth-20, Trideceth-50, Trideceth-3 Carboxylic Acid, Trideceth-4 Carboxylic Acid, Trideceth-7 Carboxylic Acid, Trideceth-8 Carboxylic Acid, Trideceth-15 Carboxylic Acid, Trideceth-19 Carboxylic Acid, Trideceth-10 Phosphate, Tridecylbenzenesulfonic Acid, Trilaureth-9 Citrate, Trimethylolpropane Hydroxypropyl Bis-Hydroxyethylamine Dendrimer, Trisodium Lauroampho PG-Acetate Chloride Phosphate, Undecanoic Acid, Undeceth-5 Carboxylic Acid, Undecylenamidopropylamine Oxide, Undecylenamidopropyl Betaine, Undecylenic Acid, Undecylenoyl Collagen Amino Acids, Undecylenoyl Glycine, Undecylenoyl Hydrolyzed Collagen, Undecylenoyl Wheat Amino Acids, Undecyl Glucoside, Wheat Germ Acid, Wheat Germamidopropylamine Oxide, Wheat Germamidopropyl Betaine, Yucca Schidigera Leaf/Root/Stem Extract, Yucca Schidigera Stem Extract, Zinc Coceth Sulfatea and Zinc Coco-Sulfate.

[1056] Green and synthetic polymers: The composition as defined herein, is advantageously combined with at least one green or synthetic polymer. Suitable cationic polymers are, for example, cationic cellulose derivatives such as, for example, the quaternized hydroxyethyl cellulose obtainable from Amerchol under the name of Polymer JR 400R, cationic starch, copolymers of diallyl ammonium salts and acrylamides, quaternized vinyl pyrrolidone/vinyl imidazole polymers such as, for example, Luviquat (BASF), condensation products of polyglycols and amines, quaternized collagen polypeptides such as, for example, Lauryldimonium Hydroxypropyl Hydrolyzed Collagen (Lamequat L, Grnau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone polymers such as, for example, amodimethicone, copolymers of adipic acid and dimethylaminohydroxypropyl diethylenetriamine (Cartaretine, Sandoz), copolymers of acrylic acid with dimethyl diallyl ammonium chloride (Merquat 550, Chemviron), polyaminopolyamides and crosslinked water-soluble polymers thereof, cationic chitin derivatives such as, for example, quaternized chitosan, optionally in microcrystalline distribution, condensation products of dihaloalkyls, for example dibromobutane, with bis-dialkylamines, for example bis-dimethylamino-1,3-propane, cationic guar gum such as, for example, JaguarCBS, JaguarC-17, JaguarC-16 of Celanese, quaternized ammonium salt polymers such as, for example, Mirapol A-15, Mirapol AD-1, Mirapol AZ-1 of Miranol and the various polyquaternium types (for example 6, 7, 32 or 37) which can be found in the market under the tradenames Rheocare CC or Ultragel 300. Suitable anionic, zwitterionic, amphoteric and nonionic polymers are, for example, vinyl acetate/crotonic acid copolymers, vinyl pyrrolidone/vinyl acrylate copolymers, vinyl acetate/butyl maleate/isobornyl acrylate copolymers, methyl vinylether/maleic anhydride copolymers and esters thereof, uncrosslinked and polyol-crosslinked polyacrylic acids, acrylamidopropyl trimethylammonium chloride/acrylate copolymers, octylacrylamide/methyl methacrylate/tert.-butylaminoethyl methacrylate/2-hydroxypropyl methacrylate copolymers, polyvinyl pyrrolidone, vinyl pyrrolidone/vinyl acetate copolymers, vinyl pyrrolidone/dimethylaminoethyl methacrylate/vinyl caprolactam terpolymers and optionally derivatized cellulose ethers and silicones. In a preferred variant, the composition according to the present invention preferably includes an un-crosslinked or polyol-crosslinked polyacrylic acid as additionally polymer component.

[1057] Perfume oils and/or fragrances: The composition according to the present invention preferably includes one or more perfume oils and/or fragrances. Suitable perfume oils are mixtures of natural and synthetic perfumes. Natural perfumes include the extracts of blossoms (lily, lavender, rose, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (anise, coriander, caraway, juniper), fruit peel (bergamot, lemon, orange), roots (nutmeg, angelica, celery, cardamom, costus, iris, calmus), woods (pinewood, sandalwood, guaiac wood, cedarwood, rosewood), herbs and grasses (tarragon, lemon grass, sage, thyme), needles and branches (spruce, fir, pine, dwarf pine), resins and balsams (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). Animal raw materials, for example civet and beaver, may also be used. Typical synthetic perfume compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Examples of perfume compounds of the ester type are benzyl acetate, phenoxyethyl isobutyrate, p-tert.butyl cyclohexylacetate, linalyl acetate, dimethyl benzyl carbinyl acetate, phenyl ethyl acetate, linalyl benzoate, benzyl formate, ethylmethyl phenyl glycinate, allyl cyclohexyl propionate, styrallyl propionate and benzyl salicylate. Ethers include, for example, benzyl ethyl ether while aldehydes include, for example, the linear alkanals containing 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonal. Examples of suitable ketones are the ionones, beta-isomethylionone and methyl cedryl ketone. Suitable alcohols are anethol, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol. The hydrocarbons mainly include the terpenes and balsams. However, it is preferred to use mixtures of different perfume compounds which, together, produce an agreeable perfume. Other suitable perfume oils are essential oils of relatively low volatility which are mostly used as aroma components. Examples are sage oil, camomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, lime-blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, ladanum oil and lavendin oil. The following are preferably used either individually or in the form of mixtures: bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, hexylcinnamaldehyde, geraniol, benzyl acetone, cyclamen aldehyde, linalool, Boisambrene Forte, Ambroxan, indole, hedione, sandelice, citrus oil, mandarin oil, orange oil, allylamyl glycolate, cyclovertal, lavendin oil, clary oil, damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romillat, irotyl and floramat.

[1058] In addition to the above-described substances, further ingredients commonly used in the food industry, cosmetic or pharmaceutical industry or for homecare products, which are suitable or customary in the compositions of the present invention, can be used.

[1059] The cosmetic or pharmaceutical, in particular dermatological, preparations according to the present invention are intended for topical application. The term topical is understood to mean external applications on a mammal's skin or mucosa, which are in particular for the protection, treatment, care and cleansing of the skin, scalp, eyelashes, eyebrows, nails, mucous membranes and hair. The mammal is preferably a human.

[1060] For topical application, the cosmetic or pharmaceutical preparation is either a rinse off or a leave on preparation.

[1061] The cosmetic or pharmaceutical or homecare products according to the present invention may be in the form of an aqueous solution, dispersions, a hydro alcoholic vehicle, a stick, an ointment, a gel, an aerosol (foams, sprays, propellant pump) and the like.

[1062] The cosmetic or pharmaceutical, in particular dermatological, preparation, preferably sunscreen product, or homecare product according to the first aspect of the present invention can be present in different forms, e.g. in the form of a dispersion, in the form of a liquid surfactant formulation, in the form of a solid surfactant formulation, in the form of a water free formulation, or in the form of an aqueous, aqueous/alcoholic, in particular aqueous/ethanolic, aqueous/glycolic or alcoholic/glycolic, in particular ethanolic/glycolic, based solution.

[1063] In a preferred variant, the cosmetic or pharmaceutical preparation or homecare product according to the first aspect of the invention is a dispersion. The term dispersion in the context of the present invention means, that the cosmetic or pharmaceutical preparation, in particular sunscreen product, or homecare product is a disperse two-phase system consisting of colloidal particles (disperse phase) and a medium in which they are suspended (disperse medium). Both phases are not miscible with each other, only with an emulsifier. Such dispersions, for example emulsions, comprise the at least one oil component (without UV-filter(s)) preferably in an amount of 1% by weight, more preferably in an amount of 3% by weight.

[1064] Preferably, the cosmetic or pharmaceutical preparations or homecare products according to the present invention take various forms such as an emulsion, in particular a O/W emulsion, a W/O emulsion, a multiple emulsion, a hydrodispersion gel, a balm, a multiple emulsion of the water-in-oil type (W/O/WO) or of the oil-in-water type (O/W/O), PIT emulsion, Pickering emulsion, a micro-emulsion, a liquid, a lotion, a suspension, a milk, an ointment, a paste, a gel, a cream based, an oil based or a liposome-based formulation or a an aerosol such as foams and sprays, including all types of silicon based emulsions.

[1065] In a most preferred variant, the cosmetic or pharmaceutical preparations or homecare products according to the present invention are in the form of an emulsion as defined herein, advantageously in the form of an oil-in-water (O/W) emulsion comprising an oily phase dispersed in an aqueous phase in the presence of an O/W or polymeric emulsifier.

[1066] If the cosmetic or pharmaceutical preparation or homecare product according to the present invention is a dispersion, preferably an emulsion, the oil component (without UV-filter(s)) is present in the cosmetic or pharmaceutical preparation in an amount of 0.01 to 50.0% by weight, based on the total weight of the composition. In a preferred variant, the cosmetic or pharmaceutical preparation comprises the oil component in an amount of 0.1 to 45.0% by weight, based on the total weight of the composition. In a particular preferred variant, the oil component is advantageously used in the cosmetic or pharmaceutical preparation in an amount of at 1.0 to 40% by weight, based on the total weight of the composition.

[1067] In a further variant, the cosmetic or pharmaceutical, preferably dermatological, preparation or homecare product according to the first of the invention is a water free formulation, i.e. an oil formulation.

[1068] If the cosmetic or pharmaceutical preparation or homecare product according to the present invention is a water free formulation, i.e. an oil formulation, the oil component is present in the cosmetic or pharmaceutical preparation in an amount of 60% by weight, preferably in an amount of 75% by weight, more preferably in an amount of 90% by weight, based on the total weight of the composition.

[1069] Such water free formulations include e.g. oils, skin butters, powders, lip stick, antiperspirant/deo sticks, and decorative cosmetics.

[1070] In addition, further water free formulations are likewise formulations on the basis of ethanol/diols/triols/glycols such as sprays or gels.

[1071] In a further alternative, the cosmetic or pharmaceutical preparation or homecare product according to the present invention is a liquid surfactant formulation.

[1072] Such liquid surfactant formulations include form example shampoo, shower gel, micellar water, liquid soap, cleansing preparations.

[1073] In a further alternative, the cosmetic or pharmaceutical preparation or homecare product according to the present invention is a solid surfactant formulation.

[1074] Such solid surfactant formulations include for example solid shampoos, solid body wash, bar soaps.

[1075] If the cosmetic or pharmaceutical preparation according to the present invention is a liquid or solid surfactant composition, the surfactant component is present in the cosmetic or pharmaceutical preparation or homecare product in an amount of 1.0 to 90.0% by weight, preferably in an amount of 1.5 to 80% by weight, more preferably in an amount of 2.0 to 70% by weight, based on the total weight of the composition.

[1076] Alternatively, the cosmetic or pharmaceutical preparation or homecare product as disclosed herein is an aqueous or an aqueous/alcoholic, preferably aqueous/ethanolic, or an aqueous/glycolic, or an alcoholic/glycolic, preferably ethanolic/glycolic, based solution. Typically, this could be glycerin in water or alcohol compositions. Said solutions are homogeneous one phase system of water/alcohol/glycol and additional components. The aqueous/alcoholic or aqueous/glycolic or alcoholic/glycolic based solution comprises an aliphatic alcohol or a glycol in an amount of 0.1 to 70.0% by weight, preferably in an amount of 0.5 to 60.0% by weight, more preferably in an amount of 1.0 to 50.0% by weight, based on the total weight of the solution. The aliphatic alcohol is preferably selected from the group consisting of ethanol, isopropanol, n-propanol. The glycol is preferably selected from the group consisting of glycerin, propylene glycol, 1,3-Propanediol, 1,2-Propanediol, 1,2-C5 to C10-alkanediols, butylene glycol or dipropylene glycol.

[1077] Preferably, the overall water content in the final aqueous based solutions can be 30% by weight, more preferably 40% by weight, most preferably 50% by weight.

[1078] Such aqueous or aqueous/alcoholic or aqueous/glycolic or alcoholic/glycolic based solutions include for example deo/antiperspirant preparations, after shave, cleansing preparations, or anti-acne preparations.

[1079] In a further preferred variant, the inventive composition is an impregnation solution in the form of an emulsion spray or ethanol/oil spray for wet wipes.

[1080] The above formulations or compositions are prepared according to usual and known methods.

[1081] The cosmetic preparation according to the present invention is a preparation for cosmetic and/or non-therapeutic use for personal care, skin protection, skin care, scalp protection, scalp care, hair care, nail care, in particular for the prevention and/or treatment of skin conditions, intolerant or sensitive skin, skin irritation, skin reddening, rosacea, wheals, pruritus (itching), skin aging, wrinkle formation, loss of skin volume, loss of skin elasticity, pigment spots, pigment abnormalities, skin dryness, flaking, greasiness, hypopigmentation and/or hyperpigmentation of the skin; or a preparation for animal care.

[1082] Examples of personal care are preferably anti-ageing preparations, skin care emulsions, body oils, body lotions, cleansing lotions, face or body balms, after shave balms, after sun balms, deo emulsions, cationic emulsions, body gels, treatment creams, skin protection ointments, moisturizing gels, face and/or body moisturizers, light protective preparations (sunscreens), micellar water, hair spray, colour protection hair care products, skin lightening product, anti-dark spot preparations, etc.

[1083] The cosmetic preparations include also make-ups, eye-care preparation, eye shadows, mascara, eyeliner, lip care preparation such as lip stick, lip gloss, nail care preparations, such as nail varnish, nail varnish removers,

[1084] The pharmaceutical, in particular dermatological, preparation according to the present invention is a preparation for the prevention and treatment of a condition of the skin or mucosa, hair or nails.

[1085] In order to be used, the cosmetic or pharmaceutical, in particular dermatological preparation according to the present invention is applied to the skin, hair, scalp and/or nails in an adequate amount in such manner as is customary with cosmetics and dermatological products.

[1086] In addition, the products and prepartions according to the present invention are homecare products. The homecare products are predominantly detergent formulations, usually liquids, powders, sprays, granules or tablets, used to remove dirt, including dust, stains, bad smells and clutter on surfaces or other types of housecleaning or laundry detergent that is added for cleaning laundry or liquid soap. Typical homecare products include all purpose cleaners, dishwashing detergens, hard floor and surface cleaners, glass cleaners, carpet cleaners, oven cleaners, laundry detergents (powder, liquid and table), fabric softeners, laundry scent, scent lotions, air fresheners, disinfectants, stain removers, carwash products, rim block gel, all aforementioned goods also in encapsulated form, air fresheners or furniture polish, etc.

[1087] Surprisingly, the addition of a mycosporine-like amino acid compound as defined herein to an antimicrobial component in food, a cosmetic or pharmaceutical preparation or homecare product has been found to synergistically enhance the antimicrobial effect thereof.

[1088] The above specified mixtures/combinations according to the first aspect of the present invention, comprising at least one antimicrobial compound (a) and at least a mycosporine-like amino acid compound (b) are characterized by a synergistically antimicrobial efficacy against a broad spectrum of microorganism, i.e. against bacteria, yeast and fungi/mould, when used in combination with an antimicrobial component, compared to their respective single mycosporine-like amino acid substances as it is demonstrated in the following examples.

[1089] Surprisingly, the synergistic antimicrobial effect can even be demonstrated for Candida, such as Candida albicans, and Aspergillus, such as Aspergillus brasiliensis, which both are known to be combated only with great difficulty.

[1090] Said synergistic antimicrobial effect is observed for the mixture including MAA-1 in combination with an antimicrobial compound.

[1091] The mixture including MAA-1 in combination with an antimicrobial compound is particularly beneficial since it has a particularly pronounced synergistic antimicrobial effect.

[1092] The mixture comprising MAA-2 in combination with an antimicrobial compound or a mixture comprising MAA-4 in combination with an antimicrobial compound are particularly advantageous.

[1093] Also, the mixture comprising MAA-6 or the mixture comprising MAA-8 synergistically reduces the microbial load when used in combination with different antimicrobials.

[1094] A synergistic effect is also true for a mixture including MAA-12 in combination with an antimicrobial compound.

[1095] A synergistic effect is particularly distinctive for a combination including MAA-13 and an antimicrobial compound.

[1096] The mixtures comprising MAA-14 or MAA-16 when used in combination with an antimicrobial compound act synergistically against microorganisms as specified herein.

[1097] Particular preferred combinations are at least one of the mycosporine-like aminic acid compounds MAA-20 to MAA-39 and an antimicrobial component.

[1098] The combinations of MAA-A or MAA-B or MAA-C and an antimicrobial compound are also beneficial since they have a particular pronounced synergistic antimicrobial effect.

[1099] With the use of the above-described mixtures/combinations including a mycosporine-like amino acid and an antimicrobial component, the microbial growth in food, or cosmetic or pharmaceutical compositions or homecare products can be considerably reduced or even inhibited, and, thus, microbial load in such formulations can be reduced.

[1100] With the above-described antimicrobial efficacy of the mixtures/combinations, including a mycosporine-like amino acid compound and an antimicrobial compound, microbial load in food, or cosmetic or pharmaceutical compositions or homecare products can be considerably reduced.

[1101] Hence, the storage stability of such formulations can be considerably improved, and, thus, the shelf live can be prolonged. Moreover, the risk of spoilage during individual customer use is significantly reduced.

[1102] The afore specified mixtures including a mycosporine-like amino acid compound in combination with an antimicrobial component display a remarkably synergistic activity and are clearly superior to the individually corresponding mycosporine-like amino acid compounds alone or the individually corresponding antimicrobial compounds and having the same concentration.

[1103] As demonstrated in the following examples, said synergistic antimicrobial effect or action was found for a mixture of MAA-1 and 4-hydroxyacetophenone (50:50), resulting in Synergy Indices of 0.75 against S. aureus, 0.75 against C. albicans, 0.56 against A. brasiliensis and 0.73 against P. aeruginosa is particularly beneficial since it has a particular pronounced synergistic antimicrobial effect against multiple microorganism. Surprisingly, the synergistic antimicrobial effect could also be demonstrated for Candida albicans and Aspergillus brasiliensis, which both are known to be combated only with great difficulty.

[1104] A synergistic antimicrobial effect or action was also found for a mixture of MAA-1 and 1,2-pentanediol (50:50), resulting in Synergy Indices of 0.80 against A. brasiliensis, 0.55 against P. aeruginosa and 0.58 against E. coli.

[1105] Also a mixture of MAA-1 and ethylhexylglycerin (50:50), act synergistically against microorganisms as specified herein, resulting in a Synergy Index of 0.23 against P. aeruginosa.

[1106] A mixture of MAA-13 and 4-hydroxyacetophenone (50:50) resulted in a Synergy Index of 0.90 against S. aureus, and a mixture of MAA-13 and 1,2-pentanediol (50:50) resulted in a Synergy Index of 0.50 against P. aeruginosa.

[1107] A synergistic antimicrobial effect or action was surprisingly also found for a mixture of MAA-20 and 4-hydroxyacetophenone (50:50) resulting in Synergy Indices of 0.90 against S. aureus, 0.78 against C. albicans and 0.71 against P. aeruginosa.

[1108] For a mixture of MAA-20 and 1,2-pentanediol (50:50) the Synergy Index was 0.93 against E. coli and for a mixture of MAA-20 and ethylhexylglycerin (50:50) the Synergy Index was 0.55 against E. coli.

[1109] With the use of the above-described mixtures including at least one mycosporine-like amino acid compound in combination with an antimicrobial compound, the microbial growth in food, or cosmetic or pharmaceutical compositions or homecare products can be considerably inhibited, and, thus, microbial load in such formulations can be reduced.

[1110] Hence, the storage stability of such formulations can be considerably improved, and, thus, the shelf life can be prolonged. Moreover, the risk of spoilage during individual customer use is significantly reduced.

[1111] The antimicrobial boosting effect obtained by use of at least one mycosporine-like amino acid compound has the advantage that the antimicrobial efficiency of the antimicrobial compound is broadened, either by achieving a higher performance of an antimicrobial compound with the same amounts, or, vice versa, by achieving the same performance with lower amounts of an antimicrobial compound, so that the overall content of the antimicrobial component in the final product can be reduced, compared to a final product including an antimicrobial component without the addition of a mycosporine-like amino acid compound.

[1112] For instance, with the addition of MAA-1 to an antimicrobial compound, the antimicrobial efficacy of a antimicrobial compound can be enhanced. Consequently, the concentration of the antimicrobial compound can be reduced while the same antimicrobial effect can be obtained.

[1113] Hence, the use of a mycosporine-like amino acid compound as defined herein in general allows for the use of less antimicrobial component in a food, cosmetic or pharmaceutical composition or homecare product for achieving the same antimicrobial effect compared to a food, cosmetic or pharmaceutical composition comprising the same antimicrobial component but without the use of the mycosporine-like amino-acid compound.

[1114] Since the mycosporine-like amino acid compounds have the advantage that they are water-soluble, the antimicrobial compound can be in admixture with the mycosporine-like amino acid compound easier incorporated into the food, cosmetic or pharmaceutical preparation or homecare product, and, thus are available in the water phase, where usually microbial contamination takes place. This is of particular benefit for products or formulations with a large oil phase, for example sunscreen products, where common preservatives are difficult to incorporate. Hence, a good compromise can be achieved when a mycosporine-like amino acid compound is combined in such a way as to boost the antimicrobial effect, while improving processability in formulations.

[1115] Due to the described advantageously properties, a mycosporine-like amino acid compound (b) as defined herein can be used for the preparation of food, cosmetic or pharmaceutical preparations or homecare products which can be better microbially stabilized thereby. The microbial stabilization allows the food, cosmetic or pharmaceutical preparations or homecare product to be stored without microbial degradation and deterioration, thus improving the shelf life of food, cosmetic or pharmaceutical preparations or homecare products.

[1116] Due to the outstanding antimicrobial boosting effect as described above, the combined use of at least one antimicrobial compound (a) and at least one mycosporine-like amino acid compound (b) is suitable for the preservation of food, cosmetic or pharmaceutical preparations or homecare products.

[1117] Thus, in a further aspect the present invention relates to the combined use of at least one antimicrobial compound (a) and at least one mycosporine-like amino acid compound (b) according to the invention for suppressing or inhibiting microorganism growth in food, a cosmetic or pharmaceutical preparations or homecare products. Here the combinations are valuable in ensuring good preservation of said products. The suppression or inhibition of the growth of microorganisms is a reduction of the microorganisms' growth rate and/or stagnation or reduction of the number of living microorganisms. By suppressing or inhibiting the microorganisms' growth, the degradation and deterioration of the cosmetic or pharmaceutical preparation, in particular during storage, which sometimes goes along with impairment of the sensory quality of the products, can be prevented or at least minimized.

[1118] In addition, the present invention relates in a further aspect to the use of at least one mycosporine-like amino acid compound as defined herein for boosting the efficacy of an antimicrobial component, preferably in food, a cosmetic or pharmaceutical preparation or a homecare product.

[1119] A use is further preferred, wherein the microorganisms are selected from the group consisting of the genus Pseudomonas, Staphylococcus, Echerichia, Candida, Aspergillus, and combinations thereof, in particular selected from the group consisting of Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans und Aspergillus brasiliensis, and combinations thereof, more particular Candida albicans und Aspergillus brasiliensis. The antimicrobial composition according to the first aspect of the present invention showed excellent efficacy against these microorganisms.

[1120] Finally, the present invention also relates to a method of boosting the efficacy of an antimicrobial compound in food, a cosmetic or a pharmaceutical preparation or homecare product. In the method according to the invention a food, a cosmetic or a pharmaceutical preparation or homecare product is provided. Next, an effective amount of an antimicrobial compound is combined with an effective amount of a mycosporine-like amino acid compound as defined herein and incorporated into the food, cosmetic or pharmaceutical preparation or homecare product thereby achieving an enhanced preservation of said products.

[1121] The present invention shall now be described in detail with reference to the following examples, which are merely illustrative of the present invention, such that the content of the present invention is not limited by or to the following examples.

EXAMPLES

Example 1

[1122] The Minimum Inhibitory Concentration (MIC) test is a test on growth inhibition. The estimation of MICs is executed in 96 well plates. Through the comparison of bacterial growth with positive and negative controls via optical density (OD), different concentrations of given test substances are evaluated.

[1123] Bacteria were cultivated under adjusted conditions based on information of the German Collection of Microorganisms and Cell Cultures (DSMZ) and stored in 10% or 50% glycerol prior to use. Afterwards, the following method was applied: Growth medium (according to microorganism) was added to each well of the microplate. Then, test-substances solved in DMSO, and strain specific benchmarks were added. Additionally, positive controls (water controls only with medium) and solvent controls (DMSO controls only with medium) were performed. Finally, the microorganisms were added in a concentration of 1 to 610.sup.6 CFU/ml (CFU=colony forming units). The incubation of the microplates was carried out at appropriate conditions.

[1124] According to the resulting growth, substance concentrations are labelled either as inhibiting or not and MIC is defined as the lowest concentration where a complete growth inhibition is visible. Experiments at concentration limits (highest concentration labelled as growth and lowest concentration labelled as inhibiting) are performed at least twice.

[1125] Tested concentrations were adjusted to performance of test substance, but in general: 5,000 ppm steps between 50,000 ppm and 10,000 ppm, and 2500 ppm steps below 10,000 ppm, finishing with 1000 ppm. To enhance resolution of the approach, additional intermediate steps were included in individual cases. For P. aeruginosa and A. brasiliensis, a maximum concentration of 25,000 ppm was applied as at this point the DMSO concentration itself showed inhibition. For ethylhexylglycerin and 1,2-pentanediol, pure substance without DMSO was tested.

[1126] To verify that the tested combinations act synergistically against microorganisms, corresponding experiments were conducted with Staphylococcus aureus, Candida albicans, Aspergillus brasiliensis, Pseudomonas aeruginosa and Escherichia coli. The synergistic activities of MAA-1 and different antimicrobial compounds in a mixture of 50% and 50% were determined by measuring the MIC of the mixture.

[1127] In order to calculate the synergy index with MIC values, the Kull equation was used as follows:

[00001]$\mathrm{SI}=\left({\mathrm{MIC}}_{\mathrm{mixture}}{P}_A\right)/{\mathrm{MIC}}_A+\left({\mathrm{MIC}}_{\mathrm{mixture}}{P}_B\right)/{\mathrm{MIC}}_B$ [1128] wherein [1129] SI is the Synergy Index according to Kull [1130] MIC.sub.A is the MIC value for Substance A [1131] MIC.sub.B is the MIC value for Substance B [1132] MIC.sub.mixture is the MIC value for the mixture of substances A and B [1133] P.sub.A is the proportion of the substance A in the mixture [1134] P.sub.B is the proportion of the substance B in the mixture

[1135] A Synergy Index (SI) with a value lower than 1 indicates a synergistic effect of the mixture that has been tested. Values higher than 1 indicate the absence of a synergistic effect.

[1136] For mixtures for which no MIC value has been determined, the calculation of an SI is not applicable (marked as n.a. in the following tables).

Example 1.1: MIC Values and Synergy Indices of MAA-1 in Combination with Either 4-hydroxyacetophenone, 1,2-pentanediol and ethylhexylglycerin Against Staphylococcus aureus, Candida albicans, Aspergillus brasiliensis, Pseudomonas aeruginosa and Escherichia coli

[1137] The synergistic activity of MAA-1 in combination with different antimicrobial compounds was determined by measuring the Minimum Inhibitory Concentrations (MIC) according to the method as described above.

TABLE-US-00004 TABLE 4 MIC in ppm Staphylococcus Candida Aspergillus Pseudomonas Escherichia Test substances aureus albicans brasiliensis aeruginosa coli MAA-1 2,500 7,500 20,000 >25,000 2,500 4-Hydroxy- 5,000 6,000 2,500 4,000 2,500 acetophenone MAA-1 and 2,500 5,000 2,500 5,000 2,500 4-Hydroxy- acetophenone (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] 0.75 0.75 0.56 0.73 1.00 MAA-1 2,500 7,500 20,000 >25,000 2,500 1,2-Pentanediol 35,000 12,500 17,500 30,000 15,000 MAA-1 and 5,000 15,000 15,000 15,000 2,500 1,2-pentanediol (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] 1.07 1.60 0.80 0.55 0.58 MAA-1 2,500 7,500 20,000 >25,000 2,500 Ethylhexylglycerin 1,000 1,000 1,000 50,000 2,500 MAA-1 and 2,500 2,500 2,500 7,500 2,500 ethylhexylglycerin (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] 1.75 1.42 1.31 0.23 1.00

[1138] For the tested antimicrobial components, synergistic effects regarding the antimicrobial efficacy were found with SI values below 1, indicating a synergism.

[1139] For a mixture of MAA-1 and 4-hydroxyacetophenone (50:50) the respective MIC values were determined, resulting in Synergy Indices of 0.75 against S. aureus, 0.75 against C. albicans, 0.56 against A. brasiliensis and 0.73 against P. aeruginosa.

[1140] For a mixture of MAA-1 and 1,2-pentanediol (50:50) the respective MIC values were determined, resulting in Synergy Indices of 0.80 against A. brasiliensis, 0.55 against P. aeruginosa and 0.58 against E. coli.

[1141] For a mixture of MAA-1 and ethylhexylglycerin (50:50) the respective MIC values were determined, resulting in a Synergy Index of 0.23 against P. aeruginosa.

[1142] This means that with the addition of MAA-1, the antimicrobial efficacy of a antimicrobial compound can be enhanced.

[1143] Consequently, with the addition of MAA-1, the concentration of the antimicrobial component can be reduced while the same antimicrobial effect can be obtained. Hence, the use of MAA-1 allows for the use of less antimicrobial component in a food, cosmetic or pharmaceutical composition for achieving the same antimicrobial effect compared to a food, cosmetic or pharmaceutical composition comprising the same antimicrobial component but without the use of MAA-1.

Example 1.2: MIC Values and Synergy Indices of MAA-13 in Combination with Either 4-hydroxyacetophenone, 1,2-pentanediol and ethylhexylglycerin Against Staphylococcus aureus, Candida albicans, Aspergillus brasiliensis, Pseudomonas aeruginosa and Escherichia coli

[1144] The synergistic activity of MAA-13 in combination with different antimicrobial compounds was determined by measuring the Minimum Inhibitory Concentrations (MIC) according to the method as described above.

TABLE-US-00005 TABLE 5 MIC in ppm Staphylococcus Candida Aspergillus Pseudomonas Escherichia Test substances aureus albicans brasiliensis aeruginosa coli MAA-13 25,000 25,000 >30,000 >30,000 >25,000 4-Hydroxy- 5,000 6,000 2,500 4,000 2,500 acetophenone MAA-13 and 4-Hydroxy- 7,500 10,000 5,000 5,000 5,000 acetophenone (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] 0.90 1.03 1.08 0.71 1.10 MAA-13 25,000 25,000 >30,000 >30,000 >25,000 1,2-Pentanediol 35,000 12,500 17,500 30,000 15,000 MAA 13 and >25,000 22,500 30,000 15,000 20,000 1,2-pentanediol (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] n.a. 1.35 1.36 0.50 1.07

[1145] For a mixture of MAA-13 and 4-hydroxyacetophenone (50:50) the respective MIC values were determined, resulting in a Synergy Index of 0.90 against S. aureus.

[1146] For a mixture of MAA-13 and 1,2-pentanediol (50:50) the respective MIC values were determined, resulting in a Synergy Index of 0.50 against P. aeruginosa.

[1147] This means that with the addition of MAA-13, the antimicrobial efficacy of an antimicrobial compound can be enhanced.

[1148] Consequently, with the addition of MAA-13, the concentration of the antimicrobial component can be reduced while the same antimicrobial effect can be obtained. Hence, the use of MAA-13 allows for the use of less antimicrobial component in a food, cosmetic or pharmaceutical composition for achieving the same antimicrobial effect compared to a food, cosmetic or pharmaceutical composition comprising the same antimicrobial component but without the use of MAA-13.

Example 1.3: MIC Values and Synergy Indices of MAA-20 in Combination with Either 4-hydroxyacetophenone, 1,2-pentanediol and ethylhexylglycerin Against Staphylococcus aureus, Candida albicans, Aspergillus brasiliensis, Pseudomonas aeruginosa and Escherichia coli

[1149] The synergistic activity of MAA-20 in combination with different antimicrobial compounds was determined by measuring the Minimum Inhibitory Concentrations (MIC) according to the method as described above.

TABLE-US-00006 TABLE 6 MIC in ppm Staphylococcus Candida Aspergillus Pseudomonas Escherichia Test substances aureus albicans brasiliensis aeruginosa coli MAA-20 >25,000 >25,000 >30,000 >30,000 15,000 4-Hydroxy- 5,000 6,000 2,500 4,000 2,500 acetophenone MAA-20 and 7,500 7,500 5,000 5,000 5,000 4-Hydroxy- acetophenone (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] 0.90 0.78 1.08 0.71 1.10 MAA-20 >25,000 >25,000 >30,000 >30,000 15,000 1,2-Pentanediol 35,000 12,500 17,500 30,000 15,000 MAA-20 and >25,000 >25,000 >30,000 >15,000 17,500 1,2-pentanediol (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] n.a. n.a. n.a. n.a. 0.93 MAA-20 >25,000 >25,000 >30,000 >30,000 15,000 Ethylhexylglycerin 1,000 1,000 1,000 50,000 2,500 MAA-20 and 2,500 2,500 2,500 >30,000 2,500 ethylhexylglycerin (mixture 50:50) Synergy Index [SI = (MICmix PA)/MICA + (MICmix PB)/MICB] 1.30 1.30 1.29 n.a. 0.55

[1150] For a mixture of MAA-20 and 4-hydroxyacetophenone (50:50) the respective MIC values were determined, resulting in Synergy Indices of 0.90 against S. aureus, 0.78 against C. albicans and 0.71 against P. aeruginosa.

[1151] For a mixture of MAA-20 and 1,2-pentanediol (50:50) the respective MIC values were determined, resulting in a Synergy Index of 0.93 against E. coli.

[1152] For a mixture of MAA-20 and ethylhexylglycerin (50:50) the respective MIC values were determined, resulting in a Synergy Index of 0.55 against E. coli.

[1153] This means that with the addition of MAA-20, the antimicrobial efficacy of an antimicrobial compound can be enhanced.

[1154] Consequently, with the addition of MAA-20, the concentration of the antimicrobial component can be reduced while the same antimicrobial effect can be obtained. Hence, the use of MAA_20 allows for the use of less antimicrobial component in a food, cosmetic or pharmaceutical composition for achieving the same antimicrobial effect compared to a food, cosmetic or pharmaceutical composition comprising the same antimicrobial component but without the use of MAA-20.

Example 2: Formulation Examples

[1155] In the following formulation examples the following five perfume oils PFO1, PFO2, PFO3, PFO4 or PFO5 were each used as fragrance.

TABLE-US-00007 TABLE F1 Composition of perfume oil 1 (PO1; amounts in b.w.) Ingredients Amount Aldehyde C12 2.0 Allyl amyl glycolate 10% dpg 5.0 Anisic aldehyde pure 5.0 Apple oliffac type 10.0 Benzylacetate 50.0 Bergamot identoil colourless 15.0 Canthoxal 5.0 Cetalox 10% ipm 3.0 Citronellol 950 40.0 Damascenone total 1% dpg 5.0 Damascone alpha 10% dpg 5.0 Damascone delta 10% dpg 2.0 Dimethyl benzyl carbinyl butyrate 2.0 Dipropylene glycol 178.0 Ebanol 2.0 Ethyl decadienoate trans cis-2.4 2.0 Florosa 5.0 Frambinon 10% dpg 7.0 Galaxolide 50% in ipm 100.0 Galbex type base 1.0 Geranyl acetate pure 2.0 Hedione 30.0 Heliotropin 10.0 Hexenyl acetate cis-3 10% dpg 1.0 Hexenyl salicylate cis-3 5.0 Hexyl cinnamic aldehyde alpha 70.0 Hexyl salicylate 50.0 Hydroxy citronellal 10.0 Iso e super 15.0 Isoraldeine 70 20.0 Leafovert 1.0 Lilial 60.0 Linalool 60.0 Linalyl acetate 20.0 Lyral 7.0 Manzanate 2.0 Phenoxanol 7.0 Phenylethyl alcohol 120.0 Sandal mysore core 2.0 Sandranol 7.0 Styralyl acetate 3.0 Tagetes rco 10% tec 2.0 Terpineol pure 20.0 Tetrahydrogeraniol 10% dpg 5.0 Tonalide 7.0 Vertocitral 10% dpg 5.0 Vertofix 15.0 Total 1000.0

TABLE-US-00008 TABLE F2 Composition of perfume oil 2 (PO2; amounts in b.w.) Ingredients Amount Acetophenone. 10% in DPG 10 n-Undecanal 5 Aldehyde C14 15 Allylamyl glycolate, 10% in DPG 20 Amyl salicylate 25 Benzyl acetate 60 Citronellol 80 d-Limonene 50 Decenol trans-9 15 Dihydromyrcenol 50 Dimethylbenzylcarbinyl acetate 30 Diphenyloxide 5 Eucalyptol 10 Geraniol 40 Nerol 20 Geranium oil 15 Hexenol cis-3. 10% in DPG 5 Hexenyl salicylate cis-3 20 Indole. 10% in DPG 10 Alpha-ionone 15 Beta-ionone 5 Lilybelle 60 Linalool 40 Methylphenyl acetate 10 Phenylethyl alcohol 275 Styrolyl acetate 20 Terpineol 30 Tetrahydrolinalool 50 Cinnamyl alcohol 10 Total: 1000

TABLE-US-00009 TABLE F3 Composition of perfume oil 3 (PO3; amounts in b.w.) Ingredients Amount Benzyl acetate 60 Citronellyl acetate 60 Cyclamenaldehyde 20 Dipropylene glycol (DPG) 60 Ethyllinalool 40 Florol (2-isobutyl-4-methyltetrahydro-2H- 30 Globalide 180 Hedione (methyldihydrojasmonate) 140 Hexenyl salicylate. cis-3 10 Vertocitral (2.4-dimethyl-3- 5 Hydratropaldehyde. 10% in DPG 5 Isodamascone (1-(2.4.4-trimethyl-2- 5 Isomuscone (cyclohexadecanone) 40 Jacinthaflor (2-methyl-4-phenyl-1.3- 10 Cis-jasmone. 10% in DPG 20 Linalool 50 Linalyl acetate 30 Methyl benzoate. 10% in DPG 25 para-Methyl cresol. 10% in DPG 10 Nerol 20 Phenylpropylaldehyde 5 2-Phenylethyl alcohol 82 Tetrahydrogeraniol 13 2.2-Dimethyl-3-cyclohexyl-1-propanol 80 Total: 1000

TABLE-US-00010 TABLE F4 Composition of perfume oil 4 (PO4; amounts in b.w.) Ingredients Amount AMBRETTOLIDE (MACRO) 10 AMBROXIDE 10% in IPM 10 BENZYL ACETATE 20 BENZYL SALICYLATE 15 BERGAMOT OIL. bergapten-free 60 CALONE 1951 10% in DPG 15 COUMARIN 5 CYCLOGALBANATER 10% in DPG 10 ALPHA -DAMASCONE 1% in DPG 20 DIHYDROMYRCENOL 10 ETHYL LINALOOL 75 ETHYL LINALYLACETATE 50 ETHYL MALTOL 1% in DEP 10 ETHYLENE BRASSYLATE (MACRO) 80 FLOROSA 40 GERANYLACETATE 10 HEDIONE HC/30 35 HEDIONE 210 HELIONAL 15 HELVETOLIDE (ALICYC) 30 HEXENYLSALICYLATE CIS-3 20 ISO E SUPER 40 LEAFOVERT 10% in DEP 10 LILIAL 80 LYRAL 20 MANDARIN OIL 10 STYRALYL ACETATE 5 SYMROSE 15 VANILLIN 10% in DEP 20 DIPROPYLENE GLYCOL (DPG) 50 TOTAL 1000

TABLE-US-00011 TABLE F5 Composition of perfume oil 5 (PO5; amounts in b.w.) Ingredients Amount AMAROCITE 10 AMBROCENIDE 10% in DPG 5 AMBROXIDE 15 AURELIONE (7/8-Cyclohexadecenone) (MACRO) 70 BERGAMOT OIL. bergapten-free 90 CALONE 1951 10% in DPG 20 CARAWAY OIL 10 CITRAL 20 COUMARIN 10 ALPHA-DAMASCONE 1% in DPG 15 DIHYDROMYRCENOL 70 ESTRAGON OIL 10 ETHYL LINALOOL 100 ETHYL LINALYLACETATE 90 EUGENOL 10 EVERNYL 5 FRUCTATE 5 GERANIUM OIL 5 HEDIONE HC/30 100 HELIONAL 10 INDOLE 10% in DPG 5 ISO E SUPER 100 KEPHALIS 5 LAVENDER OIL 40 CITRUS OIL 80 LILIAL 30 MANDARIN OIL 20 MUSCENONE (MACRO) 5 SANDRANOL 10 VANILLIN 10% in DPG 5 DIPROPYLENE GLYCOL 30 TOTAL 1000

TABLE-US-00012 TABLE F6 Composition of Aroma1 (A1; Peppermint flavour (amounts in b.w.)) Ingredients Amount Isobutyraldehyde 0.5 3-Octanol 0.5 Dimethyl sulphide 0.5 Trans-2-Hexanal 1.0 Cis-3-Hexenol 1.0 4-Terpineol, natural 1.0 Isopulegol 1.0 Piperitone, natural, from eucalyptus 2.0 Linalool 3.0 8-Ocimenyl acetate 10% in triacetin 5.0 Isoamyl alcohol 10.0 Isovaleraldehyde 10.0 Alpha-Pinene, natural 25.0 Beta-Pinene, natural 25.0 Neomenthol. Racemic 40.0 Eucalyptiol (1.8-cineol).natural 50.0 L-Menthyl acetate of the formula D 70.0 L-Menthone 220.0 D-Isomenthone 50.0 L-Menthol 483.5 Nonenolide 1.0 TOTAL 1000

[1156] The above perfume oils PO1, PO2, PO3, PO4 or PO5 or aroma A1 were incorporated into the formulations presented below.

[1157] In the following formula the amounts are indicated as % by weight.

Cosmetic Formulations/Sunscreen Formulations (Compositions)

[1158] Deodorant Spray with ACH [1159] Sport Fit Deo [1160] Biotic Acne Control Gel [1161] Cleansing Micellar Gel [1162] Shampoo Sulfate-Free. [1163] Antidandruff Shampoo. [1164] Fresh Hair Shampoo. [1165] Anti-itch hair conditioner, leave on [1166] Hair Refreshener Mist [1167] Anti-Wrinkle Night Emulsion [1168] Antibacterial Body Lotion, sprayable [1169] Refreshing and soothing after sun cream [1170] Emulsion with low emulsifier content [1171] Natural Night Cream Aloe [1172] Clear Anti-Acne Wipe [1173] After-Shave Wipes. [1174] Sensi Scalp (Green Solid Shampoo) [1175] Hygiene & Care Hand Cream [1176] Mouthwash without alcohol (ready to use) [1177] Sunscreen lotion (o/w; broadband protection). [1178] Sun protection soft cream (w/o), SPF 40

TABLE-US-00013 TABLE F7 Deodorant Spray with ACH Ingredients INCI Amount Triethylcitrate Triethylcitrate 3.0 Solubilizer PEG-40 Hydrogenated 1.0 Castor Oil, Trideceth-9, Propylene Glycol, Aqua Ethanol 96% Ethanol 30.0 Ethylhexylglycerin Ethylhexylglycerin 0.3 SymDeo B125 2-Methyl 5- 0.25 Cycloheylpentanol SymClariol Decylene Glycol 0.25 Frescolat ML Menthyl Lactate 0.6 Tego Cosmo P 813MB Polyglyceryl-3 Caprylate 0.5 Locron L (50%) Aqua, Aluminium 25.0 Chlorohydrate Perfume oil PO1, PO2, PO3, PO4, or Parfum 0.5 PO5 MAA-2 0.8 Water, demin. Aqua add 100

TABLE-US-00014 TABLE F8 Sport Fit Deo Ingredients INCI Amount SymLite G8 Glyceryl caprylate 0.15 Ethanol Alcohol denat add 100 SymClariol Decylene Glycol 0.25 SymDeo B125 2-Methyl 5-Cyclohexylpentanol 0.25 Frescolat ML Menthyl Lactate 0.5 Extrapone Ginseng Propylene Glycol, Aqua, Panax 0.1 ginseng root extract, Lactic acid Extrapone Peppermint Aqua, Propylene Glycol, 0.1 Mentha Piperita Leaf extract Ethylhexyglycerin Ethylhexylglycerin 0.2 MAA-13 0.7 MAA-20 0.3 Perfume oil PO1, PO2, Parfum 1.0 PO3, PO4, or PO5

TABLE-US-00015 TABLE F9 Biotic Acne Control Gel Ingredients INCI Amount Water, distilled Water (Aqua) add 100 SymSave H Hydroxyacetophenone 0.5 Carbopol Acrylates/C10-30 0.5 Alkyl Acrylate Ultrez 21 Polymer Crossploymer MAA-3 0.25 MAA-13 1.0 Solubilizer PEG-40 Hydrogenated Castor 2.5 Oil, Trideceth-9, Propylene Glycol, Aqua SymClariol Decylene Glycol 0.5 SymMollient W/S Trideceth-9, PEG-5 1.0 Isononanoate, Aqua Hydrolite- 5 green Pentylene Glycol 5.0 Dragosantol Bisabolol 0.05 Farnesol Farnesol 0.3 Ethanol Alcohol, Aqua 5.0 Flowerpone Lavender PEG-40 Hydrogenated Castor 0.5 Oil, Trideceth-9, Pentylene Glycol, Lavandula Angustifolia Flower Extract, Propylene Glycol, Bisabolol SymReboot L19 Maltodextrin, Lactobacillus 0.5 Ferment Sodium Hydroxide Aqua, Sodium 1.1 10% solution Hydroxide Colour Colour 0.2 Perfume oil PO1; PO2; Fragrance 0.3 PO3; PO4 or PO5

TABLE-US-00016 TABLE F10 Cleansing Micellar Gel Ingredients INCI Amount Water, distilled Water (Aqua) add 100 MAA-16 0.6 MAA-1 0.4 Carbopol Carbomer 0.7 ETD 2050 Polymer Hydroviton PLUS 2290 Aqua, Pentylene glycol, Glycerin Fructose, Urea, Citric acid, Sodium hydroxide, Maltose 2.0 Sodium pca, Sodium chloride Sodium lactate, Trehalose Allantoin, Sodium hyaluronate Glucose SymOcide PS Phenoxyethanol, 1.0 Decylene glycol, 1,2-hexanediol Sodium Hydroxide Aqua, Sodium Hydroxide 3.28 10% solution SymMollient W/S Trideceth-9, PEG-5 1.0 Isononanoate, Aqua SymSol PF-3 Aqua, Pentylene glycol, Sodium 3.0 lauryl sulfoacetate, Sodium oleoyl sarcosinate, Sodium chloride, Sodium oleate Perfume oil PO1; PO2; Parfum 1.0 PO3; PO4 or PO5 SymVital AR Zingiber officinale 0.2 (ginger) root extract Extrapone Seaweed Aqua 1.0 Butylene glycol Fucus vesiculosus extract Actipone Dandelion Juice Glycerin 1.0 (Organic) GW Taraxacum officinale juice Aqua Colour II Colour 0.20 Caprylhydroxamic Acid Caprylhydroxamic Acid 0.1 Phenylpropanol Phenylpropanol 0.2

TABLE-US-00017 TABLE F11 Shampoo Sulfate-Free Ingredients INCI Amount Aqua/Water Aqua add 100 Akypo Foam RL 40 Sodium Laureth-5 15.00 Carboxylate MAA-13 1.0 MAA-7 0.15 Plantacare 2000 UP Decyl Glucoside 5.00 Dissolvine GL-47-S Tetrasodium Glutamate Diacetate SymOcide PH Phenoxyethanol, 1.45 Hydroxyacetophenone, Caprylyl Glycol, Aqua Aqua/Water Aqua 10.00 Novethix L-10 Polymer Acrylates/Beheneth-25 7.00 Methacrylate Copolymer Dehyton PK 45 Cocamidopropyl Betaine 10.00 SymMollient W/S Trideceth-9, PEG-5 0.50 Isononanoate, Aqua SymCalmin Pentylene Glycol, Butylene 1.00 Glycol, Hydroxyphenyl Propamidobenzoic acid Antil 141 Liquid Propylene Glycol, PEG-55 2.00 Proplyene Glycol Oleate Acusol OP 301 Styrene/Acrylates 1.00 Copolymer SymHair Restore Glycerin, Triticum Vulgare 1.00 Protein, Aqua Perfume oil PO1; PO2; Parfum 1.00 PO3; PO4; or PO5

TABLE-US-00018 TABLE F12 Antidandruff Shampoo Ingredients INCI Amount Water, distilled Water (Aqua) add 100 MAA-1 1.5 Polymer JR 400 Polyquaternium-10 0.4 Texapon NSO IS Sodium Laureth Sulfate 40.0 Dehyton K Cocamidopropyl Betaine 8.0 Plantacare 2000 UP Decyl Glucoside 2.0 Citric Acid 10% solution Citric Acid 0.8 Frescolat X-cool Menthyl Ethylamido Oxalate 0.5 Sym Triol Caprylyl Glycol, 1,2-Hexanediol, 0.8 Methylbenzyl Alcohol Crinipan AD Climbazole 0.5 SymMollient W/S Trideceth-9, PEG-5 Isononanoate, 2.0 Water (Aqua) Tinogard Q Tri(tetramethylhydroxypiperodonol) 0.02 Citrate Sodium Chloride Sodium Chloride 0.5 Perfume oil PO1; PO2; Fragrance 0.4 PO3; PO4 or PO5

TABLE-US-00019 TABLE F13 Fresh Hair shampoo Ingredients INCI Amount Aqua Aqua add 100 EDTA B Powder Disodium EDTA 0.1 MAA-2 0.8 MAA-13 0.6 Nativacare 5600 Zea Mays (Corn Starch) 1.0 Rheocare XGN Xanthan Gum 0.5 Texapon NSO UP Sodium Laureth sulfate 35.0 Dehyton K Cocamidopropyl betaine 8.0 Plantacare 2000 UP Decyl Glucoside 4.0 Perfume oil PO1, PO2, Parfum 1.0 PO3, PO4, or PO5 SymSave H Hydroxyacetophenone 0.5 Hydrolite 6 1,2-Hexanediol 1.0 SymClariol Decylene Glycol 0.3 Frescolat ML cryst Menthyl Lactate 1.0 SymCalmin Pentylene Glycol, Butylene 0.2 Glycol, Hydroxyphenyl propamidobenzoic acid Crinipan AD Climbazole 0.2 Propylene Glycol Propylene Glycol 2.0 SymHair Shield Pentylene Glycol, Aqua, 1.0 Glycerin, Triticum vulgare bran extract, 1,2-Hexanediol, Capryly glycol Sodium Hydroxide 10% solution Aqua, Sodium hydroxide 2.2

TABLE-US-00020 TABLE F14 Anti-itch hair conditioner, leave on Ingredients INCI Amount Dragosantol 100 Bisabolol 0.1 Dehyquart A CA Cetrimonium Chloride 0.5 Dehyquart SP Quaternium-52 4.0 Dracorin CE Glyceryl Stearate Citrate 1.0 Drago-Oat-Active Water (Aqua), Butylene 2.0 Glycol, Avena Sativa (Oat) Kernel Extract Perfume oil PO1; PO2; Fragrance 0.1 PO3; PO4; or PO5 Nativacare 5600 Zea (Mays) Corn Starch 1.5 Lara Care A-200 Galactoarabinan 1.5 Neutral Oil Caprylic/Capric Triglyceride 1.0 PCL Liquid 100 Cetearyl Ethylhexoate 0.3 Ucare Polymer JR 400 Polyquaternium-10 0.1 Propylene Glycol Propylene Glycol 0.8 SymGlucan Aqua, Glycerin, 1,2-Hexandiol, 5 Caprylyl Glycol, Beta-Glucan Crinipan PMC green Propanediol Caprylate 0.5 SymMollient W/S Trideceth-9, PEG-5 2.0 Isononanoate, Water (Aqua) SymOcide PH Phenoxyethanol, 1.2 Hydroxyacetophenone, Caprylyl Glycol, Aqua SymSol PF3 Water, Pentylene Glycol, 1.5 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate MAA-2 1.2 MAA-8 0.7 Water, demineralized Water (Aqua) add 100

TABLE-US-00021 TABLE F15 Hair Refresher Mist Ingredients INCI Amount SymDeo Plus Lauryl alcohol, 0.5 Phenoxyethanol, 2- Benzyleptanol, Decylene Glycol Perfume oil PO1; PO2; Parfum 0.1 PO3; PO4; or PO5 Frescolat ML nat Mentyl Lactate 0.3 Crinipan PMC green Propanediol Caprylate 0.3 Solubilizer PEG-40 Hydrogenated Castor 5.0 oil, Trideceth-9, Propylene glycol, Aqua SymCalmin Pentylene Glycol, Butylene 0.2 Glycol, Hydroxyphenyl Propamidobenzoic acid SymControl Scalp Water (Aqua), Glycerin, 2.0 Mannitol, Tetraselmis Suecica Extract Genuvisco CG-131 Carrageenan 0.2 Propylene Glycol Propylene Glycol 3.0 Butylene Glycol Butylene Glycol 3.0 MAA-13 0.35 Aqua Aqua add 100 Sodium Gluconate Sodium Gluconate 0.2 Caprylhydroxamic acid Caprylhydroxamic acid 0.01 Sodium Benzoate Sodium benzoate 0.4 Actipone Rosemary GW Glycerin, Aqua, Rosmarinus 0.5 officinalis leaf extract

TABLE-US-00022 TABLE F16 Anti-Wrinkle Night Emulsion Raw material INCI Amount Emulsiphos F Potassium cetyl phosphate 2.5 Hydrogenated palm glycerides Dragoxat 89 Ethylhexyl isononanoate 2.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 2.0 SymRepair 100 Hexyldecanol, Bisabolo, 2.5 Cetylhydroxyproline Palmitade, Stearic Acid, Brassica Campestris (Rapeseed) Sterols Caprylic/Capric Triglyceride Caprylic/Capric Triglyceride 3.0 SymMollient S green Cetearyl Nonanoate 2.0 Isoadipate Diisopropyl Adipate 2.0 Sym Decanox HA Caprylic/Capric Triglyceride, 2.0 Hydroxymethdoxyphenyl Decanone MAA-4 0.2 Alpha Tocopherol DL Tocopherol 0.5 Argan Oil Argania Spinosa Kernel Oil 1.0 Jojoba Oil Simmondsia Chinensis |1.0 Seed Oil Avocado Oil CA Persea Gratissima Oil 1.0 SymUrban Benzylidene 0.5 Dimethoxydimethylindanone Food Color Iron CI77491 0.005 Oxide RED E172 Keltrol CG-BT Xanthan Gum 0.2 Cosmedia SP Sodium Polyacrylate 0.5 Aqua/Water Aqua add 100 Glycerin Glycerin 3.0 MAA-13 1.0 Edeta BD Disodium EDTA 0.1 SymSave H Hydroxyacetophenone 0.5 Sym Diol 68 1,2 Hexanediol, Caprylyl Glycol 0.5 Actipone Laminaria Glycerin, Aqua, Laminaria 1.0 Saccharina GW CA Saccharina Extract Macadamia Oil Macadamia Integrifolia Seed Oil 2.0 SymGlucan Aqua, Glycerin, 1,2-Hexanediol, 2.0 Caprylyl Glycol, Beta-Glucan Hydrovition PLUS 2290 Aqua, Pentylene Glycol, 2.0 Glycerin, Fructose, Urea, Citric Acid, Sodium hydroxide, Mtose, Sodium PCA, Sodium Chloride, Sodium Lactate, Trehalose, Allantoin Sodium Hyaluronate, Glucose Sym Vital AR Zingiber Officinale 0.2 (Ginger) Root Extract Ethanol 96% Alcohol Denat. 3.0 Sodium hydroxide Aqua, Sodium 0.7 10% solution Hydroxide Perfume oil PO1; PO2; Parfum 0.3 PO3; PO4; or PO5

TABLE-US-00023 TABLE F17 Antibacterial body lotion, sprayable Ingredients INCI Amount Potassium Sorbate Potassium Sorbate 0.2 Dow Corning 345 Fluid Cyclomethicone 0.5 Dracorin GOC Glyceryl Oleate Citrate, 2.0 Caprylic/Capric Triglyceride Drago-Calm Water, Glycerin, Avena Sativa 1.0 (Oat) Kernel Extract Dragosantol 100 Bisabolol 0.1 Perfume oil PO1; PO2; Fragrance 0.3 PO3; PO4 or PO5 Hydrolite-5 Pentylene Glycol 5.0 Neutral Oil Caprylic/Capric Triglyceride 4.0 MAA-11 0.2 Paraffin Oil Mineral Oil 4.0 PCL Liquid 100 Cetearyl Ethylhexoate 7.0 Pemulen TR-2 Acrylates/C10-30 Alkyl Acrylate 0.2 Crosspolymer Sodium Hydroxide Sodium Hydroxide 0.4 (10% aqueous sol.) Sym Deo MPP Dimethyl Phenylbutanol 0.5 SymRelief 100 Bisabolol, Zingiber Officinale 0.1 (Ginger) Root Extract MAA-13 1.1 SymSave H 4-Hydroxyacetophenone 0.2 Water (demineralized) Water (Aqua) add 100

TABLE-US-00024 TABLE F18 Refreshing and Soothing After Sun Cream Ingredients INCI Amount Dracorin CE Glyceryl Stearate Citrate 2.5 Cutina GMS V Glyceryl Stearate 2.5 Coconut Oil Cocos Nucifera Oil 3.0 SymMollient PDCC Propanediol Dicaprylate/ 8.0 Caprate Plantoil Triglyceride Caprylic/Capric Triglyceride 4.0 MAA-1 1.5 Tocopherol Tocopherol 0.05 Demin. Water Aqua Add100 Glycerin Glycerin 2.0 SymOcide PS Phenoxyethanol, Decylene 1.0 Glycol, 1,2 Hexanediol Nativacare 8600 Oryza Sativa (Rice) Starch 1.0 Keltrol CG-SFT Xanthan Gum 0.4 Sirhamnose Silanetriol (and) Rhamnose 3.0 D-Panthenol 75 L Panthenol 1.0 Perfume oil PO1; PO2; Parfum 0.3 PO3; PO4; or PO5

TABLE-US-00025 TABLE F19 Emulsion with low emulsifier content Ingredients INCI Amount Water, demin. Aqua add 100 Hydrolite 5 green Pentylene Glycol 3.0 Sym Save H Hydroxyacetophenone 0.5 Glycerin Glycerin 1.0 Nativacare 5600 Zea Mays (Corn) Starch 1.5 SymMollient S green Cetaryl Nonanoate 3.0 MAA-13 2.0 Lanette O Cetearyl Alcohol 2.5 Plant oil Triglyceride Caprylic/Capric Triglyceride 4.0 SymMollient PDCC Propanediol Dicaprylate/ 3.0 Caprate Dracorin CE Glyceryl Stearate Citrate 0.5 Rheocare XGN Xanthan Gum 0.1 Amigum Sclerotium Gum 0.25 Citric Acid 10% solution Aqua, Citric Acid 0.1 Perfume oil PO1; PO2; Parfum 0.3 PO3; PO4; or PO5

TABLE-US-00026 TABLE F20 Natural Night Cream Aloe Ingredients INCI Amount Deionised Water Aqua add 100 MAA-7 0.25 MAA-13 2.0 Glycerin 99.5% Glycerin 2.0 Dermofeel PA-3 Sodium Phytate; Aqua; Alcohol 0.1 Dermosoft 1388 eco Glycerin, Aqua, Sodium 3.0 Levulinate, Sodium Anisate Veegum Ultra Granules Magnesium Aluminium Silicate 0.5 Keltrol CG-RD Xanthan Gum 0.5 Dermofeel SL Sodium Stearoyl Lactylate 2.0 Dermofeel PS Polyglyceryl-3 Stearate 3.0 Dermosoft Sodium Caproyl/ 0.8 decalact MB Lauroyl Lactylate Phytosqualan, veg. Grade Squalane 4.0 Cegosoft SBE Butyrosperum Parkii Butter; 2.0 Tocopherol Cutina GMS Glyceryl Stearate 2.0 Lanette O Cetearyl Alcohol 1.0 Sunflower oil Helianthus Annuus Seed Oil 4.0 Dermofeel sensolv Isoamyl Laurate 5.0 Aloe Vera Gel Aloe Barbadensis 0.3 Concentrate 10/1 Leaf Juice Perfume oil PO1; PO2; Parfum 0.3 PO3; PO4; or PO5

TABLE-US-00027 TABLE F21 Clear Anti Acne Wipe Ingredients INCI Amount Farnesol Farnesol 0.2 Methylisothiazolinone Methylisothiazolinone 0.1 Isopropanol Isopropanol 45.0 MAA-1 2.5 Water Water (Aqua) add 100 Camomile CL Chamomilla Recutita 1.0 (Matricaria) Flower Water, Butylene Glycol, Pentylene Glycol Citric Acid 10% Citric Acid 0.03 aqueous solution Perfume oil PO1; PO2; Fragrance 0.1 PO3; PO4 or PO5 Hydroxyethoxyphenyl Hydroxyethoxyphenyl 0.4 Butanone Butanone

TABLE-US-00028 TABLE F22 After-Shave Wipes Ingredients INCI Amount Acrylates/C10-30 Alkyl Acrylates/C10-30 Alkyl 0.1 Acrylate Crosspolymer Acrylate Crosspolymer MAA-13 2.8 MAA-2 0.4 Water Water (Aqua) add 100 Sodium Hydroxide 10% solution Aqua, Sodium Hydroxide 0.13 Glycerin Glycerin 4.0 DOWSIL 2501 Bis-PEG-18 Methyl Ether 2.0 Cosmetic Wax Dimethyl Silane Aloe Vera Aloe Vera 0.6 Propylene Glycol Propylene Glycol 0.3 Witch Hazel Extract Hamamelis Virginiana 0.7 (Witch Hazel) Extract C12-15 Alkyl Benzoate C12-15 Alkyl Benzoate 2.7 Polysorbate-20 Polysorbate-20 0.5 DOWSIL 9040 Silicone Cyclopentasiloxane (and) 3.5 Elastomer Blend Dimethicone Crosspolymer XIAMETER PMX-1184 Dimethicone (and) Trisiloxane 5.8 Silicone Fluid Perfume oil PO1; PO2; Fragrance 0.3 PO3; PO4 or PO5 DOWSIL 9509 Silicone Dimethicone/Vinyl 2.0 Elastomer Suspension Dimethicone Crosspolymer (and) C12-14 Pareth-12 Phytic Acid Phytic Acid 0.1 Salicylic Acid Salicylic Acid 0.1

TABLE-US-00029 TABLE F23 Sensi-SCALP (Green Solid Shampoo) Ingredients INCI Amount AMISOFT MS-11 Sodium Myristoyl Glutamate 30.0 ELFAN AT 84 Sodium cocoyl Isethionate 15.0 ImerCare 02K-S Kaolin 18.8 Hydrolite 5 green Pentylene Glycol 1.5 Dragosantol 100 Bisabolol 0.1 MAA-13 0.4 Potassium Sorbate Potassium Sorbate 0.3 Aqua/Water Aqua add 100 MAA-5 0.7 SymDecanox HA Caprylic/Capric Triglyceride, 1.5 Hydroxymethoxyphenyl decanone Alpha Tocopherol DL Tocopherol 0.5 Cetiol SB45 Butyrospermum parkii butter 13.0 Extrapone Rooibus GW Aqua, Glycerin, Aspalathus 1.0 Linearis leaf extract SymReboot L19 Maltodextrin, Lactobacillus 0.5 Ferment SymOleo Vita7 Glycine soja oil, Gossypium 1.0 herbaceum seed oil, mangifera idica seed butter, olea europaea fruitoil, persea gratissima oil, prununs amygdalus dulcis (sweet almond) oil, Theobroma cacao seed butter Perfume oil PO1; PO2; Parfum 1.2 PO3; PO4; or PO5

TABLE-US-00030 TABLE F24 Hygiene and Care Hand Cream Ingredients INCI Amount Emulsiphos F Potassium Cetyl Phosphate, 1.5 Hydrogenated Palm Glycerides PCL-Solid Stearyl Heptanoate, Stearyl 2.5 Caprylate Dragoxat 89 Ethylhexyl Isononanoate 1.5 Caprylic/Capric Triglyceride Caprylic/Capric Triglyceride 2.0 Tegosoft MM Myristyl Myristate 2.5 SymDecanox H Caprylic/Capric Triglyceride, 1.0 Hydroxymethoxyphenyl decanone Frescolat X-Cool Menthyl ethylamido oxalate 0.5 SymCare O Hexyldecanol, Pentylene 2.0 Glycol, 4-t-Butylcylohexanol, Bisabolol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic acid, Stearic acid, Brassica campestris (Rapeseed)Sterols, Zingiber officinale (Ginger)Root extract MAA-7 0.5 Beeswax Beeswax 1.0 Cosmedia SP Sodium Polyacrylate 0.8 Aristoflex AVC Ammonium 0.6 Acryloydimethyltaurate/VP Copolymer Aqua/Water Aqua add 100 MAA-13 1.5 Neutrol MGDA Trisodium Dicarboymethyl 0.2 Alaninate SymSave H Hydroxyacetophenone 0.5 Hydroviton PLUS 2290 Aqua, Pentylene Glycol, 2.0 Glycerin, Fructose, Urea, Citric acid, Sodium hydroxide, Maltose, Sodium PCA, Sodium chloride, Sodium Lactate, Trehalose, Allantoin, Sodium Hyaluronate, Glucose Actipone Stinging Nettle Juice Glycerin, Urtica Dioica Juice, 1.0 Aqua SymEssence Camomile CC Chamomilla Recuitta 1.0 (Matricaria), Flower/Leaf/Stem Water Colour 0.9 Alpha Tocopherol DL Tocopherol 0.5 Perfume oil PO1; PO2; Parfum 0.4 PO3; PO4; or PO5 SymOcide C o-cymen-5-ol 0.1 SymDeo Plus Lauryl alcohol, 0.5 Phenoxyethanol, 2- Benzylheptanol, Decylene Glycol

TABLE-US-00031 TABLE F25 Mouthwash without alcohol (ready to use) Ingredients INCI Amount Cremophor CO40 PEG_40 Hydrogenated castor oil 2.5 SymGuard CD Phenylpropanol, o-cymen-5-ol, 0.5 Decylene Glycol Propylene Glycol Propylene Glycol 5.0 Flavour/Aroma 1 A1 Aroma 0.2 Aqua Aqua add 100 MAA-13 0.35 Sorbitol Liq. EP 70% Sorbitol 10.0 Sodium Saccharin Sodium Saccharin 0.07 Sodium Fluorid Sodium Fluorid 0.18 SymSave H Hydroxyacetophenone 0.3

TABLE-US-00032 TABLE F26 Sunscreen lotion (o/w; broadband protection) Ingredients INCI Amount Hydrolite-7 1,2-heptanediol 0.6 MAA-13 1.5 1,2-octanediol 1,2-octanediol 0.2 2,3-octanediol 2,3-octanediol 0.01 Benzyl Salicylate Benzyl Salicylate 0.5 Carbopol Ultrez-10 Carbomer 0.2 Dow Corning 246 Fluid Cyclohexasiloxane and 2.0 Cyclopentasiloxane Dragosantol 100* Bisabolol 0.3 EDETA BD Disodium EDTA 0.1 Emulsiphos F Potassium Cetyl Phosphate, 1.5 Hydrogenated Palm Glycerides Perfume oil PO1; PO2; Perfume 0.4 PO3; PO4; or PO5 Frescolat MGA Menthone Glycerol Acetal 0.3 Glycerol 85% Glycerin 4.7 Keltrol RD Xanthan Gum 0.2 Lanette O Cetearyl Alcohol 1.0 Neo Heliopan 357 Butyl Methoxy-dibenzoyl-methane 1.0 Neo Heliopan AP Disodium Phenyl Dibenzimidazole 10.0 (10% as sodium salt) Tetrasulfonate Neo Heliopan AV Ethylhexyl Methoxy-cinnamate 3.0 Neo Heliopan Hydro Phenylbenz-imidazole Sulfonic 6.7 (15% as sodium salt) Acid Neo Heliopan MBC 4-Methylbenzyl-idene Camphor 1.5 Neo Heliopan OS Ethylhexyl Salicylate 5.0 Neutral Oil Caprylic/Capric Triglyceride 2.0 SymMatrix Maltodextrin, Rubus Fruticosus 0.3 (Blackberry) Leaf Extract Methylisothiazolinone Methylisothiazolinone 0.1 SymOcide BHO Hydroxyacetophenone, Benzyl 0.5 alcohol, Caprylyl glycol, Aqua Tegosoft TN C12-15 Alkyl Benzoate 5.0 Tocopherol Acetate Tocopheryl Acetate 0.5 Triethanolamine, 99% Triethanolamine 0.5 Water (demineralized) Water (Aqua) add 100

TABLE-US-00033 TABLE F27 Sun protection soft cream (w/o), SPF 40 Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 5.0 dipolyhydroxystearate Copherol 1250 Tocopheryl acetate 0.5 Permulgin 3220 Ozocerite 0.5 Zinc stearate Zinc stearate 0.5 Tegosoft TN C12-15 Alkyl benzoate 10.0 Neo Heliopan E1000 Isoamyl-p-methoxycinnamate 2.0 Neo Heliopan 303 Octocrylene 5.0 Neo Heliopan MBC 4-Methylbenzylidene camphor 3.0 Zinc oxide, neutral Zinc oxide 5.0 MAA-13 1.0 Water, distilled Water (aqua) add 100 EDETA BD Disodium EDTA 0.1 Glycerol Glycerol 4.0 Magnesium sulfate Magnesium sulfate 0.5 Perfume oil PO1; Perfume 0.3 PO2; PO3; PO4; or PO5 Symdiol 68 Hexanediol, Caprylylglycol 0.5 1,2-heptanediol 1,2-heptanediol 0.2 2,3-heptanediol 2,3-heptanediol 0.01 1,2-octanediol 1,2-octanediol 0.2 2,3-octanediol 2,3-octanediol 0.01

Homecare Products (Compositions)

[1179] All purpose cleaner [1180] APC alkaline [1181] Detergent liquid light duty [1182] Dishwash liquid manual [1183] Fabric softener [1184] Fabric softener concentrate, encapsulated [1185] Hand soap, liquid [1186] Scent Lotion, encapsulated [1187] Cleaner, liquid, citric acid

TABLE-US-00034 TABLE F28 All purpose cleaner No Ingredients Amount 1 Fettalkoholethoxylat 4 2 Sulfonic acid, C 13-17-sec-Alkyl-, Sodium salt 6.2 3 2-octyl-2H-isothiazol-3-one 0.1 4 Fragrance 3.5 5 MAA-13 1.0 6 1,2-heptanediol 0.9 7 Aqua add 100

Colorless Liquid, PH 7

TABLE-US-00035 TABLE F29 APC alkaline No Ingredients Amount 1 Coco-Glycoside 1 2 Benzalkonium Chloride 0.2 3 Sodiumbicarbonat 0.1 4 Tri-sodiumcitrate-dihydrate 0.1 5 Methylglycinediacetic acid 0.1 6 1,2-Benzisothiazol-3(2H)-on 0.1 7 Fragrance 0.1 8 1,2-heptanediol 0.5 9 MAA-3 0.5 10 Hydroxyacetophenone 0.3 11 Aqua add 100

Colorless Liquid, pH 9

TABLE-US-00036 TABLE F30 Detergent liquid light duty No Ingredients Amount 1 Cocos fatty acid 0.85 2 potassium hydroxide 0.45 3 2-octyl-2H-isothiazol-3-one 0.2 4 Sulfonic acid, C 13-17-sec-Alkyl-, Sodium salt 20 5 Sodium Laureth Sulfate 3 6 Trideceth-9 5 7 Sodium Chloride 1.3 8 MAA-7 0.1 9 1,2-heptanediol 0.9 10 Fragrance 0.5 11 Aqua add 100 12 Hydroxyacetophenone 0.2

Liquid, pH 7.3

TABLE-US-00037 TABLE F31 Dishwash liquid manual No Ingredients Amount 1 Sodium Laureth Sulfate add 100 2 Ethanol 2.9 3 lauramine oxide 7.7 4 propylene glycol 1.9 5 Phenoxyethanol 0.1 6 Benzisothiazolinone, Methylisothiazolinone, Laurylamine 0.1 Dipropylenediamine 7 1,2-heptanediol 0.5 8 sodium chloride 3.85 9 Fragrance 0.3 10 Benzyl Alcohol 0.2 11 MAA-13 1.0

Colorless Liquid, pH 8.5

TABLE-US-00038 TABLE F32 Fabric softener No Ingredients Amount 1 Di-(Talg Carboxyethyl) Hydroxyethyl methylammonium- 5.5 methosulfat 2 Simethicone 0.3 3 2-octyl-2H-isothiazol-3-one 0.1 4 1,2-heptanediol 0.5 5 Fragrance 0.2 6 Aqua add 100 7 Phenoxyethanol 0.2 8 MAA-2 1.5

Liquid, pH 3

TABLE-US-00039 TABLE F33 Fabric softener concentrate, encapsulated No Ingredients Amount 1 Di-(Talg Carboxyethyl) Hydroxyethyl methylammonium- 16.6 methosulfat 2 2-octyl-2H-isothiazol-3-one 0.1 3 Simethicone 0.3 4 magnesium chloride 0.8 5 encapsulated perfume oil 0.3 6 crosslinked cationic polymer 0.15 7 MAA-13 0.6 8 1,2-heptanediol 0.5 9 Fragrance 0.6 10 Aqua add 100 11 Glyceryl Caprylate 0.1

White Liquid, pH 2.5

TABLE-US-00040 TABLE F34 Hand soap, liquid No Ingredients Amount 1 Sodium Laureth Sulfate 18 2 Cocoamidopropylbetaine 6 3 Cocamide DEA 3 4 citric acid 0.5 5 sodium chloride 1.9 6 Glycerol 2 7 Fragrance 0.2 8 MAA-13 0.25 9 Aqua add 100 10 Propanediol Caprylate 0.3

Slightly Colored Liquid, pH 6

TABLE-US-00041 TABLE F35 Scent Lotion with capsules No Ingredients Amount 1 microcrystalline cellulose/cellulose gum 1 2 PEG-40 hydrogenated Castor oil/Trideceth-9 0.5 3 encapsulated perfume oil 1 4 2-octyl-2H-isothiazol-3-one 0.1 5 Fragrance 5 6 1,2-heptanediol 1 7 Aqua add 100 8 MAA-20 0.4

White Emulsion, PH Neutral

TABLE-US-00042 TABLE F36 Cleaner, liquid, citric acid No Ingredients Amount 1 Sulfonic acid, C 13-17-sec-Alkyl-, Sodium salt 1 2 Xanthan gum 0-3 3 citric acid 5 4 1,2heptanediol 0.25 5 Fragrance 0.3 6 Aqua add 100 7 Anisic Acid 0.1 8 MAA-13 0.6

Liquid, pH 2