A PRESERVATIVE COMPOSITION

Abstract

Disclosed is the use of a preservative composition comprising or consisting of glycolipids, said glycolipids being selected from at least one spirostan-3-glycosides according to formula (I), A to D.

Claims

1. A method of increasing antimicrobial stabilization of a composition, the method comprising including in the composition a preservative composition comprising or consisting of glycolipids, said glycolipids being selected from the group consisting of at least one spirostan-3-glycoside according to formula (I) ##STR00012## wherein R1 stands for H.sub.2 or O R2 stands for H or OH R3 stands for H, CH.sub.3, or CH.sub.2OH R4 stands for OH, OGlucosyl, OGalactosyl, ORhamnosyl, OXylosyl, or OArabinosyl . . . has the meaning of a single or double bond wherein the composition comprises cosmetic, detergent or food preparations, wherein said composition is active against at least one of the following microorganisms: Actinomyces viscosus Alicyclobacillus acidoterrestris Alternaria alternata Aspergillus brasiliensis Bacillus cereus Bacillus licheniformis Botrytis cinerea Brettanomyces naardenensis Byssochlamys fulva Campylobacter jejuni Clostridium perfringens Clostridium sporogenes Corynebacterium xerosis Enterobacter cloacae Enterococcus faecalis Fusobacterium nucleatum subsp. vincentii Gluconacetobacter liquefaciens Lactobacillus paracasei ssp. paracasei Lactobacillus plantarum ssp. plantarum Leuconostoc lactis Leuconostoc mesenteroides ssp. mesenteroides Listeria monocytogenes Malassezia furfur Pasteurella multocida ssp. multocida Penicillium expansum Phanerochaete chrysosporium Porphyromonas gingivalis Pseudomonas aeruginosa Pseudomonas fluorescens Saccharomyces cerevisiae Salmonella enterica ssp. enterica Ser. typhimurium Staphylococcus aureus Streptococcus mutans Yarrowia lipolytica Zygosaccharomyces bailii Zygosaccharomyces rouxii

2. The method according to claim 1, wherein said glycolipids are selected from the group consisting of the following structures A to D: TABLE-US-00067 Compound Structure A B C D

3. The method according to claim 1 wherein the composition comprising said glycolipids in amounts ranging from 0.0000001 to 1.0 wt.-percent-calculated on the total composition.

4. The method according to claim 1 wherein the composition comprising said glycolipids in amounts ranging from 0.000001 to 0.1 wt.-percent-calculated on the total composition.

5. The method according to claim 1 wherein the composition comprising said glycolipids in amounts ranging from 0.00001 to 0.01 wt.-percent-calculated on the total composition.

6. The method according to claim 1 wherein the composition further comprises at least one preservative (component b) different from compounds according to formula (I) (component a).

7. The use method according to claim 6, wherein said additional preservative (component b) is selected from the group consisting of benzoic acid and parahydroxybenzoic acid, their esters and salts, benzyl benzoate, propionic acid and its salts, salicylic acid and its salts, 2,4-hexadienoic acid (sorbic acid) and its salts, levulinic acid and its salts, anisic acid and its salts, perillic acid and its salts, cinnamic acid and its salts, formaldehyde and paraformaldehyde, 4-hydroxy benzaldehyde, ortho-, meta-, and para-anisic aldehyde, cinnamic aldehyde, cinnamic alcohol, 2-hydroxybiphenyl ether and its salts, 2-zinc-sulfidopyridine N-oxide, inorganic sulfites and bisulfites, sodium iodate, chlorobutanolum, 4-ethylmercury-(II) 5-amino-1,3-bis(2-hydroxybenzoic acid), its salts and esters, dehydracetic acid, formic acid, 1,6-bis(4-amidino-2-bromophenoxy)-n-hexane and its salts, the sodium salt of ethylmercury-(II)-thiosalicylic acid, phenylmercury and its salts, 10-undecylenic acid and its salts, 5-amino-1,3-bis(2-ethylhexyl)-5-methyl-hexahydropyrimidine, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitro-1,3-propanediol, 2,4-dichlorobenzyl alcohol, N-(4-chlorophenyl)-N-(3,4-dichlorophenyl)-urea, 4-chloro-m-cresol, 2,4,4-trichloro-2-hydroxy-diphenyl ether, 4-chloro-3,5-dimethylphenol, 1,1-methylene-bis(3-(1-hydroxymethyl-2,4-dioximidazolidin-5-yl) urea), poly-(hexamethylenediguanide) hydrochloride, (Benzyloxymethoxy)-methanol hexamethylenetetramine, 1-(3-chloroallyl)-3,5,7-triaza-1-azonia-adamantane chloride, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, 1,3-bis-(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, 1,2-dibromo-2,4-dicyanobutane, 2,2-methylene-bis(6-bromo-4-chlorophenol), bromochlorophene, mixture of 5-chloro-2-methyl-3 (2H)isothiazolinone, 2-methyl-3 (2H)-isothiazolinone and with magnesium chloride and magnesium nitrate, 2-Octyl-2H-isothiazol-3-one, 1,2-benzisothiazol-3 (2H)-one, 2-benzyl-4-chlorophenol, 3-(4-Chlorphenoxy)-1,2-propanediol (Chlorphenesin), 2-chloroacetamide, chlorhexidine, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, N-alkyl(C.sub.12-C.sub.22)trimethyl-ammonium bromide and chloride, 4,4-dimethyl-1,3-oxazolidine, N-hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N-hydroxy-methylurea, 1,6-bis(4-amidino-phenoxy)-n-hexane and its salts, glutaraldehyde, 5-ethyl-1-aza-3,7-dioxabicyclo(3.3.0) octane, 3-(4-chlorophenoxy)-1,2-propanediol, hyamines, alkyl(C.sub.8-C.sub.18)-dimethyl-benzyl-ammonium chloride, alkyl-(C.sub.8-C.sub.18)-dimethyl-benzylammonium bromide, alkyl-(C.sub.8-C.sub.18)-dimethyl-benzyl-ammonium saccharinate, benzyl hemiformal, 3-iodo-2-propynyl butylcarbamate, sodium hydroxymethyl-aminoacetate or sodium hydroxymethyl-aminoacetate, imidazolidinylurea, diazolidinylurea, sodium hydroxymethylglycinate, DMDM hydantoin, Tropolone, (Ethylendioxy)dimethanol, 2-Brom-2-(brommethyl) pentandinitril, N-(3-Aminopropyl)-N-dodecylpropan-1,3-diamin, ,,-trimethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol, pyridine-2-thiol-1-oxide, sodium salt, Tetrahydro-1,3,4,6-tetrakis(hydroxymethyl) imidazo[4,5-d]imidazol-2,5(1H,3H)-dion, 1,3-bis(hydroxymethyl)-1-(1,3,4-tris(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl) urea (Diazolidinyl Urea), 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione, 3-Acetyl-2-hydroxy-6-methyl-4H-pyran-4-one, cetyl pyridium chloride, caprylhydroxamic acid, sorbohydroxamic acid and their mixtures; 1,3-propanediol, methyl propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 1,5-pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,2-decanediol, ethylhexylglycerin, hexoxy-propan-1,2-diol, heptoxypropan-1,2-diol, octoxy-propan-1,2-diol, 3-phenoxy-propan-1,2-diol, 3-benzyloxy-propan-1,2-diol, 3-phenylethyloxy-propan-1,2-diol, 3-phenylpropyloxy-propan-1,2-diol, 3-methylbenzyloxy-propan-1,2-diol, sorbitan caprylate, triclosan, climbazole, Octopirox (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 (1H)-pyridone, 2-aminoethanol), chitosan, farnesol, 2-butyloctanoic acid, 2-Benzylheptan-1-ol, glycerol monolaurate, bis(2-pyridylthio) zinc 1,1-dioxide, N,N-(decane-1,10-diyldipyridin-1-yl-4-ylidene)-dioctan-1-amine dihydrochloride (octenidine dihydrochloride), thymol, eugenol, benzyl alcohol, 2-phenyethyl alcohol, 3-phenyl propanol, 2-phenoxyethanol, 1-phenoxy-propan-2-ol, 3-phenoxypropanol, benzyloxymethanol, 4-hydroxyacetophenone and mixtures thereof.

8. A preservative composition comprising or consisting of glycolipids, said glycolipids being selected from the group consisting of at least one of the following structures A and D: TABLE-US-00068 Compound Structure A D

Description

EXAMPLES

Manufacturing Examples

Example 1: Isolation of Spirostan Glycosides in

A) Extraction, Isolation and Identification of Compounds of Formula A to B

[0159] 1.0 kg dried plant material was extracted subsequently with 12.5l methanol-MTB-ether (50:50 v/v) and methanol (100%) at room temperature for 24 h. Both extracts were combined and the solvent evaporated in vacuum. The extract yield depends on the used plant species and the part of the plant. Typically, the extract yield is about 5 to 30% of the dried plant material.

B) Pre-Fractionation by Reverse Phase Chromatography

[0160] The raw extract was subjected to a reverse phase medium pressure chromatography to enrich the compounds of interest. Reverse phase MPLC allows to remove sugars and lipids as well as other secondary metabolites like flavonoids very efficiently and to reach enriched fractions of compounds of interest, which could be put on a second fractions step by HPLC using finer RP material. Sometimes it makes sense, to combine different MPLC prefractionations methods to get a more specific enrichment of selected saponins, e.g. by combination of RP18 and RP4 material.

C) Second Purification Step by Reverse Phase Chromatography

[0161] Pure compounds were isolated by reverse phase chromatography using different fractions from the first separation step by MPLC. To reach a purity of >90% per compound sometimes several repeated separations by HPLC were necessary. Promising fractions from the preparative HPLC runs detected by light scattering detection ELSD were analyzed by LCMS. The solvent of all fractions containing compounds of interest was removed in vacuum followed by a freeze-drying step. Isolated compounds were characterized by LCMS and 1D and 2D NMR spectroscopy.

D) Isolated Compounds

TABLE-US-00002 Com- pound Structure Plant source A [00007] Hosta plantaginea roots B [00008] Paris polyphylla roots C [00009] Paris polyphilla roots D [00010] Hosta plantaginea roots [00011]

Example 2: Antimicrobial Activity

[0162] Compounds are dissolved at a concentration of 20 mg/ml using 100% DMSO. [0163] Preculture: yeast and bacteria are plated on potato dextrose agar, resuspended in potato dextrose broth and CFU via OD measurement determined; adjusting CFU of the strain in PDB pH 3.8. [0164] Preculture: for mycel forming fungi spores were directly used after thawing of cryopreserved stocks of known titre. [0165] Final titre used for the assay: Yeast strains 5*103 CFU/ml, Bacteria 1*106 CFU/ml, Fungi (spores) 5*104 CFU/ml [0166] Potato dextrose broth pH 3.8 was used as assay matrix [0167] 500 ppm (0.05%) of the compounds were screened (final DMSO 2.5% (v/v)) [0168] Volume: 100 l in 96-well format [0169] Positive controls: potassium sorbate, sodium benzoate & triclosan [0170] 28 C. to 30 C., static incubation [0171] Incubation time depending on spoilage organism between 2 and 8 days [0172] Visual evaluation (per eye, for fungi with binocular magnification)
Antimicrobial activities are reported in Table 1.

TABLE-US-00003 TABLE 1 Antimicrobial activities (Minimal Inhibitory Concentration (MIC) in g/ml) of tested compounds compound Taxon Strain ID A B C D Actinomyces viscosus DSM43798 >80 >80 >80 >80 Alicyclobacillus acidoterrestris DSM 2498 40 140 80 40 Alternaria alternata DSM 12633 >80 >80 >80 >80 Aspergillus brasiliensis DSM 1988 >80 >80 >80 >80 Bacillus cereus DSM4490 >80 >80 >80 >80 Bacillus licheniformis DSM 13 >80 >80 >80 >80 Botrytis cinerea DSM 5145 >80 >80 >80 >80 Brettanomyces naardenensis CBS 6115 >80 >80 >80 >80 Byssochlamys fulva DSM 1808 >80 >80 >80 >80 Campylobacter jejuni DSM 4688 >80 >80 >80 >80 Candida albicans ATCC10231 >80 >80 >80 >80 Candida parapsilosis ATCC 20384 >80 >80 >80 >80 Cladosporium cladosporioides DSM19653 >80 >80 >80 >80 Clostridium perfringens DSM 756 >80 >80 >80 >80 Clostridium sporogenes ATCC 19404 80 80 80 80 Corynebacterium xerosis DSM 20743 >80 >80 >80 >80 Cutibacterium acnes DSM 1897 >80 >80 >80 >80 Enterobacter cloacae DSM 6234 >80 >80 >80 >80 Enterococcus faecalis ATCC 7080 >80 >80 >80 >80 Fusobacterium nucleatum subsp. vincentii DSM 19507 80 >80 >80 80 Gluconacetobacter liquefaciens DSM 5603 140 40 40 140 Lactobacillus paracasei ssp. paracasei DSM 46331 >80 >80 >80 >80 Lactobacillus plantarum ssp. plantarum DSM 20174 40 400 400 40 Leuconostoc lactis DSM 20202 80 >80 >80 80 Leuconostoc mesenteroides ssp. mesenteroides DSM 20343 >80 >80 >80 >80 Listeria monocytogenes DSM 20600 >80 >80 >80 >80 Malassezia furfur DSM 6170 >80 80 80 >80 Pasteurella multocida ssp. multocida DSM 16031 >80 >80 >80 >80 Penicillium expansum DSM 62841 >500 >500 >500 >500 Phanerochaete chrysosporium DSM 1556 >80 >80 >80 >80 Porphyromonas gingivalis DSM 20709 >80 >80 >80 >80 Pseudomonas aeruginosa DSM 1117 >80 >80 >80 >80 Pseudomonas fluorescens DSM50337 >80 >80 >80 >80 Saccharomyces cerevisiae DSM 2548 >80 >80 >80 >80 Salmonella enterica ssp. enterica Ser. typhimurium DSM 17058 >80 >80 >80 >80 Staphylococcus aureus DSM 2569 >80 >80 >80 >80 Streptococcus mutans DSM 20523 >80 >80 >80 >80 Yarrowia lipolytica DSM 70561 >80 >80 >80 >80 Zygosaccharomyces bailii DSM 70834 >80 >80 >80 >80 Zygosaccharomyces rouxii DSM 7525 500 500 500 500

[0173] The examples clearly demonstrate that the spirostan glycosides according to the present invention exhibit a serious activity against a wide spectrum of microorganisms, which typically can be found in products of daily life as foodstuff, petfood or cosmetics. The performance of spirostan glycosides according to the present invention is comparable to sorbic and benzoic acid, common natural preservatives, and can be synergistically increased either by blending two or more terpene glycosides according to the invention or by using blends of said glycolipids with secondary preservatives like sorbic acid, benzoic acid, lactic acid, ethanol or PHB (esters).

Formulation Examples Food

[0174] The following examples F1 to F2 show various formulations for food preparations. Saponin stands for one or more spirostan glycosides according to claim 1.

Example F1

[0175] An Italian Salad dressing formulation is prepared as follows:

TABLE-US-00004 Ingredient Parts Part I water 70.0 Vinegar 7.0 Sodium Chloride 2.0 Sweetener 4.0 Gum 0.4 Flavors 0.9 Part II Vegetable Oil 5.3 Part III Water 6.2 Vinegar 4.2 Spices and Flavors 1.8 Parts 1 and 2 are mixed and homogenized. Part 3 is then added and thoroughly mixed to form a homogenous mixture. 400 ppm of saponin is added to the dressing formula.

Example F2: Ketchup

Aqueous Phase

TABLE-US-00005 ground tomato 25.9 cider vinegar 20.7 water 44.3 Sundried tomatoes 2.1 sodium chloride 1.8 dehydrated minced garlic 1.1 frozen oregano 0.4 basil 0.5 Xanthan gum 0.2 white onion powder 2.5 sucrose 7.0 EDTA 0.0007 saponin 0.05

Oil Phase

TABLE-US-00006 soybean oil 53.3 olive oil 46.7

Formulation Examples Petfood

[0176] The following examples P1 to P4 show various formulations for pet food preparations. Saponin stands for one or more spirostan glycosides according to claim 1.

Example P1

[0177] This example describes the preparation of a 60% moisture, microbiologically-stable food product simulating meat chunks which is suitable for use as a dog food. The food is prepared from the following ingredients:

TABLE-US-00007 Ingredient Parts Wheat gluten 10.0 Soya bean oil meal 4.0 Poultry meal 3.0 Meat meal 1.5 Corn meal 1.2 Tallow 5.0 Carrageenan 2.5 Potassium sorbate 0.3 Tween 80 0.25 Span 80 0.75 Saponin 0.5 High fructose corn syrup 15.0 (80% solids, 90% fructose) Water 56.0

[0178] To prepare the food, the carrageenan is added to the water at 70 C. and stirred to dissolve. The Tween 80, polyoxyethylene sorbitan monoleate available from Atlas Chemical, potassium sorbate, benzyl alcohol and the high fructose corn syrup (Isomerose 900, available from Clinton Corn Products) are added to the carrageenan solution and stirred vigorously to dissolve. The tallow is melted and the Span 80, sorbitan monooleate, available from Atlas Chemical, is added to it and mixed thoroughly. The tallow and aqueous solution are then mixed vigorously to emulsify. The remaining dry components are added with stirring to blend with the emulsion. The finished mix is added to a pan and autoclaved at 15 lbs gauge pressure for 20 minutes to heat set the mass. The heat-set cohesive product has a moisture content of 60% and is microbiologically stable. Without the glycolipid component this formulation would not be microbiologically stable.

Example P2

[0179] This example describes the production of a 70% moisture, microbiologically stable food product simulating meat chunks from the following ingredients:

TABLE-US-00008 Ingredient Parts Wheat gluten 7.48 Soya bean oil meal 2.96 Poultry meal 2.23 Meat meal 1.11 Corn meal 0.88 Tallow 3.70 Carrageenan 1.85 Potassium sorbate 0.30 Span 80 0.75 Tween 80 0.25 Saponin 0.50 High fructose corn syrup 10.10 Water 66.90 The process is the same as in Example 1.

Example P3

[0180] This example describes the preparation of a microbiologically-stable gravy having moisture content of 60%. The formulation is as follows:

TABLE-US-00009 Ingredient Parts Meat & bone meal 9.45 Yeast 1.35 Corn flour 1.35 Dried whey 1.35 Whole egg solids 1.35 Tallow 9.45 High fructose corn syrup 20.23 Tween 80 0.25 Span 80 0.75 Saponin 0.50 Kelcosol 0.14 Water 54.0

[0181] The process according to this example calls for first mixing the Span 80 with the tallow in melted condition. Next, a solution containing the high fructose corn syrup, water, potassium sorbate, Tween 80, kelcosol, sodium alginate, available from Kelco Co., and benzyl alcohol is prepared by heating the water to 60 C. and mixing. The solution is then stirred vigorously with the tallow to emulsify. The remaining dry materials are then added and stirred vigorously. No heating is necessary other than in the initial mixing of the fat and aqueous phases.

Example P4

[0182] This example describes the preparation of a microbiologically-stable gravy having a moisture content of 70%. The following ingredients are combined according to the process of Example 3:

TABLE-US-00010 Ingredient Parts Meat & bone meal 7.0 Corn flour 1.0 Brewers yeast 1.0 Dried whey 1.0 Whole egg solids 1.0 Tallow 7.0 High fructose corn syrup 15.0 Kelcosol 0.1 Span 80 0.75 Tween 80 0.25 Saponin 0.50 Water 65.30

Formulation Examples Cosmetics & Detergents

[0183] The following examples F1 to F56 show various formulations for preparations. Formulation 1 stands for one or more spirostan glycosides according to claim 2.

TABLE-US-00011 TABLE F1 Liquid soap; transparent (Amounts in % b.w.) Ingredients INCI Name Amount Tagat O 2 PEG-20 Glyceryl Oleate 2.5 Coconut oil diethanolamine Cocamide DEA 5.0 condensate Abil B 8842 Cyclomethicone 0.5 Sodium laurylethersulfate. Sodium Laureth Sulfate 35.0 28% Tego-Betaine L7 Cocamidopropyl Betaine 5.0 Soap. 25% Coconut acid. Potassium 20.0 salt. Potassium Oleate Hydrolite 5 1,2-propanediol 0.4 Formulation 1 0.3 Water Water Ad 100

TABLE-US-00012 TABLE F2 Syndet soap; liquid (Amounts in % b.w.) Ingredients INCI Name Amount Elfan OS 46 Sodium Olefin C14-C16 Sulfonate 35.5 Armoteric LB Lauryl Betaine 8.0 Elfan SG 10.0 Elfacos GT 282 L Talloweth-60 Myristyl Glycol 3.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 4.0 Hydrolite 5 Green Hydrolite 5 Green 0.4 Preservative Methylchloroisothiazolinone 0.1 Formulation 1 0.4 Water Water Ad 100

TABLE-US-00013 TABLE F3 Cosmetic lotion for body wash (Amounts in % b.w.) Ingredients INCI Name Amount Lumerol K 28 Disodium Laureth Sulfosuccinate. 33.0 Cocamidopropyl Betaine. Magnesium Lauryl Sulfate Amphotensid B 4 Cocamidopropyl Betaine 10.0 Perlglanzmittel MIPA-Pareth-25 Sulfate. Glycol 4.0 GM 4055 Stearate Sodium Chloride Sodium Chloride 2.0 Avocado oil Persea Gratissima (Avocado) Oil 3.0 Water Water Ad 100 Hydrolite 5 Hydrolite 5 Green 0.5 Euxyl K727 Phenoxyethanol. Methyldibromo 0.3 Glutaronitrile. Isothiazolinones Formulation 1 0.6

TABLE-US-00014 TABLE F4 Cosmetic lotion for body wash with Triclosan (Amounts in % b.w.) Ingredients INCI Name Amount Texapon N 25 Sodium Laureth Sulfate 37.5 Lamepon S Potassium Cocoyl Hydrolyzed Collagen 28.0 Lamesoft LMG Hydrogenated Tallow Glycerides. TEA- 5.0 Cocoyl Hydrolyzed Collagen Lamesoft 156 Glyceryl Laurate. TEA-Cocoyl Hydrolyzed 5.0 Collagen Sodium Chloride Sodium Chloride 1.7 Irgasan DP 300 Triclosan 0.5 Water Water Ad 100 Hydrolite 5 Hydrolite 5 Green 0.3 Euxyl K703 Phenoxyethanol. Benzoic Acid. 0.4 Dehydroacetic Acid Formulation 1 0.4

TABLE-US-00015 TABLE F5 Intimate wash (Amounts in % b.w.) Ingredients INCI Name Amount Tegobetaine HS Cocamidopropyl Betaine. Glyceryl 15.0 Laurate Tagat L 2 PEG-20 Glyceryl Laurate 2.0 Arlacide G Chlorhexidine Digluconate 0.1 Rewoquat B 50 Benzalkonium Chloride 0.1 Lactic Acid. 80% Lactic Acid 0.1 Water Water Ad 100 Hydrolite 5 Hydrolite 5 Green 0.2 Euxyl K700 Potassium Sorbate. Benzyl Alcohol. 0.3 Phenoxyethanol Formulation 1 0.5

TABLE-US-00016 TABLE F6 Liquid soap (Amounts in % b.w.) Ingredient INCI Amount Deionized water Water 2.0 Soap bases mix Sodium tallowates/palmitates 95.8 Titanium dioxide Titanium dioxide 1.0 Hydrolite 5 Hydrolite 5 Green 1.2 Preservatives Phenoxyethanol 0.5 Formulation 1 0.5

TABLE-US-00017 TABLE F7 Shampoo (Amounts in % b.w.) Ingredients Amount Sodium lauryl ether sulfate (e.g. Texapon NSO) 12 Cocamidopropyl betaine (e.g. Dehyton K) 2 Sodium chloride 1.4 Citric acid 1.3 1,2-pentanediol (Hydrolite 5) 0.3 Phenoxyethanol. methyl-. ethyl-. butyl- and propylparaben 0.5 Formulation 1 0.5 Water Ad 100

TABLE-US-00018 TABLE F8 2-in-1 Shampoo (Amounts in % b.w.) Ingredients INCI Name Amount Deionized water Water Ad 100 Plantacare PS 10 Sodium Laureth Sulfate. 20.0 Lauryl Glucoside Euperlan PK 771 Glycol Distearate. 6.0 Sodium Lauryl Sulfate. Cocamide MEA. Laureth-10 Sodium chloride Sodium Chloride 1.4 Citric acid monohydrate Citric acid 0.1 crystalline Hydrolite 5 Hydrolite 5 Green 0.5 Dragocid Liquid Phenoxyethanol, Parabens 0.5 Formulation 1 0.5

TABLE-US-00019 TABLE F9 Anti-dandruff Shampoo (Amounts in % b.w.) Ingredients Amount Climbazole 0.50 Sodium Laureth Sulfate 37.00 Cocamidopropyl Betaine 8.00 PEG-6 Caprylic/Capric Glycerides 2.50 Laureth-2 2.00 Water (Aqua). Glycerol. Thymus Vulgaris 0.50 (Thyme). Flower/Leaf Extract Rosmarinus Officinalis (Rosemary) Leaf Water. 0.50 Water (Aqua). Butylene Glycol. Pentylene Glycol Bisabolol 0.10 Panthenol 0.50 Polyquaternium-10 0.40 1,2-pentanediol (Hydrolite 5) 0.50 Phenoxyethanol. Methylparaben. Ethylparaben. 0.70 Butylparaben. Propylparaben. Isobutylparaben Formulation 1 0.30 Water (Aqua) Ad 100

TABLE-US-00020 TABLE F10 Hair conditioner with Crinipan. rinse-off (Amounts in % b.w.) Ingredients INCI Name Amount Lanette O Cetearyl Alcohol 4.00 Dragoxat 89 Ethylhexyl Isononanoate 2.00 Genamin KDM-P Behentrimonium Chloride 1.00 SF 1550 Phenyl Trimethicone 0.10 Neo Heliopan Benzophenone-3 0.10 BB Crinipan AD Climbazole 0.80 Glycerol 99.5 P. Glycerol 6.00 Water Water (Aqua) Ad 100 Actipone Water (Aqua). Butylene Glycol. Malic 0.50 Alpha Pulp Acid. Actinidia Chinensis (Kiwi)Fruit Juice. Citrus. Aurantium Dulcis (Orange). Juice. Citrus Paradisi (Grapefruit) Juice. Pyrus Malus (Apple) Juice. Trideceth-9. PrunusAmygdalus Dulcis (Sweet Almond) Seed Extract Extrapone Propylene Glycol. Water (Aqua). Butylene 0.50 Bamboo P Glycol. Bambusa Vulgaris Shoot Extract Sodium Hydroxide Sodium Hydroxide 0.40 10% solution Colour I Colour 0.60 Colour II Colour 0.30 Hydrolite 5 Hydrolite 5 Green 0.40 Preservative Methylparaben 0.20 Formulation 1 Hydroxyacetophenone 0.70

TABLE-US-00021 TABLE F11 Sprayable hair conditioner with zinc pyrithrione. leave-on (Amounts in % b.w.) Ingredients INCI Name Amount Monomuls 60-35 C Hydrogenated Palm Glycerides 1.70 Cetiol OE Dicaprylyl Ether 7.20 Abil 100 Dimethicone 3.60 Dehyquart F 75 Distearoylethyl Hydroxyethylmonium. 4.00 Methosulfate. Cetearyl Alcohol Eumulgin B1 Ceteareth-12 3.50 Cetiol S Diethylhexylcyclohe xane 7.20 D-Panthenol Panthenol 0.10 Glycerol 99.5 P. Glycerol 1.50 Water Water (Aqua) Ad 100 Actipone Rosemary Water (Aqua). Propylene. Glycol. 0.10 Rosmarinus Officinalis. (Rosemary) Leaf Extract Frescolat ML Menthyl Lactate 0.50 Cryst. Dragosantol100 Bisabolol 0.10 Zinc Omadine Zinc pyrithione 0.10 Hydrolite 5 Hydrolite 5 0.40 Phenonip phenoxyethanol. methylparaben. 0.30 ethylparaben. butylparaben. propylparaben. isobutylparaben Formulation 1 0.5

TABLE-US-00022 TABLE F12 Hair conditioner with UV protection (Amounts in % b.w.) Ingredients I NCI Name Amount Renex PEG 6000 PEG-150 2.50 Hair Conditioner Cetyl alcohol. behentrimonium chloride. 3.00 Base Triticum Vulgare (Wheat) bran extract. linoleic acid PCL-Solid Stearyl heptanoate. stearyl caprylate 0.50 Dow Corning 5200 Laurylmethicone copolyol 0.50 Natrosol 250 HR Hydroxyethylcellulose 0.50 Benzophenone-4 Benzophenone-4 1.00 Neo Heliopan AP Disodiumphenyldibenz-imidazole 1.00 tetrasulphonate Amino methyl Amino methyl propanol 2.00 propanol Dow Corning 949 Amodimethicone. cetrimonium chloride. 2.00 cationic emulsion trideceth-12 Hydrolite 5 Hydrolite 5 0.80 1.2-hexanediol 1.2-hexanediol 0.50 Formulation 1 0.50 Water Water (Aqua) Ad 100

TABLE-US-00023 TABLE 13 Shower gel (Amounts in % b.w.) Ingredients INCI Amount Deionized water Water Ad 100 Plantacare PS 10 Sodium Laureth Sulfate. 20.0 Lauryl Glucoside Sodium chloride Sodium Chloride 1.4 Citric acid monohydrate Citric Acid 1.3 crystalline Hydrolite 5 Hydrolite 5 0.6 SymDiol68 1.2-hexanediol. Caprylyl glycol 0.4 Formulation 1 0.4

TABLE-US-00024 TABLE F14 Shaving foam (Amounts in % b.w.) Ingredients Amount Dem. Water 77.2 Triethanolamine 4.0 Edenor L2 SM (Stearinic acid. Palmitinic acid) (Cognis) 5.3 Laureth-23 3.0 Stearylalcohol 0.5 Sodium lauryl sulfate 3.0 Extrapone Seaweed (water. propylene glycol. potassium 1.0 iodide. Fucus Vesiculosus Extract) Dragosantol (Bisabolol. Farnesol) 0.1 1,2-pentanediol (Hydrolite 5) 1.0 Euxyl K220 (Methylisothiazolinone. Ethylhexylglyerol) 0.6 Formulation 1 0.3 Propane. butane 4.2 Bar 4.0

TABLE-US-00025 TABLE F15 Depilatory cream (Amounts in % b.w.) Ingredients Amount Cetearyl alcohol 10.0 Ceteareth-12 2.0 PCL-Liquid (Cetearylethylhexanoate. Isopropylmyristate) 3.0 Dragosantol (Bisabolol. Farnesol) 0.1 Edenor L2 SM (Stearinic acid. Palmitinic acid) 1.0 Dem. Water 52.2 Urea 5.0 Dem. Water 10.0 Calcium thioglycolate 6.0 Sodium hydroxide solution. 10% 10.0 1,2-pentanediol (Hydrolite 5) 0.5 Neo Dragocid Powder (Methyl parabene. sorbinic acid. 0.2 Dehydro acetic acid. Propyl parabene) Formulation 1 0.4

TABLE-US-00026 TABLE F16 After Shave Tonic (Amounts in % b.w.) Ingredients INCI Amount SymSol PF-3 Water (Aqua). Pentylene Glycol. 3.00 Sodium Lauryl Sulfoacetate. SodiumOleoyl Sarcosinate. Sodium Chloride. Disodium Sulfoacetate. SodiumOleate. Sodium Sulfate SymSitive 1609 Pentylene Glycol. 4-t- 1.00 Butylcyclohexan ol Frescolat ML Menthyl Lactate 0.30 Glycerol 99.5 P. Glycerol 5.00 Water Water (Aqua) Ad 100 Extrapone Glacier Glycerol. Water (Aqua) 1.00 Water GW SymCalmin Butylene Glycol. Pentylene Glycol. 0.50 Hydroxyphenyl Propamidobenzoic Acid Dragosine Carnosine 0.10 Hydrolite 5 Pentylene Glycol 5.00 Ethanol 96% Alcohol Denat. 5.00 Colour Pigment Colour Pigment 0.05 Hydrolite 5 1,2-pentanediol 0.15 Formulation 1 Hydroxyacetophenone 1.00

TABLE-US-00027 TABLE F17 Deodorant formulation in the form of a roll-on gel (Amounts in % b.w.) Ingredients Amount 1.3-butylene glycol 2.00 PEG-40-hydrogenated castor oil 2.00 Hydroxyethylcellulose 0.50 1,2-pentanediol (Hydrolite 5) 0.30 1.3-propanediol 0.50 3-phenylpropanol 0.40 Ethylhexyl glycerin 0.10 Formulation 1 0.50 Water ad 100.00

TABLE-US-00028 TABLE F18 Clear deo anti-perspirant roll-on in % b.w.) Ingredients INCI Amount Methocel E4M Premium Hydroxypropyl Methylcellulose 0.50 Water Water (Aqua) Ad 100 Neo-PCL Water Trideceth-9. PEG-5 Ethylhexanoate. 1.00 Soluble N Water (Aqua) Solubilizer PEG-40 Hydrogenated Castor Oil. 3.00 Trideceth-9. Propylene Glycol. Water (Aqua) Deolite Dimethyl Phenylpropanol. 0.50 Pentylene Glycol Locron LW Aluminium Chlorohydrate 25.00 Aloe Vera Gel Aloe Barbadensis Leaf Juice 1.00 Concentrate 10/1 Propylene Glycol 1.2 Propylene Glycol 4.00 99 P GC Ethanol 96% Alcohol Denat. 30.00 Hydrolite 5 1,2pentanediol 1.00 Formulation 1 Hydroxyacetophenone 0.25

TABLE-US-00029 TABLE F19 Deodorant stick (Amounts in % b.w.) Ingredients Amount Sodium stearate 8.00 PPG-3 Myristyl ether 70.00 1.2-propylene glycol 10.00 1.1-dimethyl-3-phenylpropanol 0.20 2-butyloctanoic acid 0.20 1,2-pentanediol (Hydrolite 5) 0.60 Heptoxy-1.2-propanediol 0.20 Phenoxyethanol 0.30 Formulation 1 0.50 Water Ad 100

TABLE-US-00030 TABLE F20 Zirconium suspensoid antiperspirant stick (Amounts in % b.w.) Ingredients INCI Amount PCL Liquid 100 Cetearyl ethylhexanonate to 100 Silicone Fluid 345 Cyclomethicone 10.00 CRODACOL C90 Cetyl Alcohol 8.00 SYNCROWAX HGLC C18-36 Triglyceride 8.00 CRODAMOL PTC Pentaerythritol Tetracaprylate/ 5.00 Caprate SYNCROWAX HRC Tribehenin 4.00 VOLPO N5 Oleth-5 1.00 Titanium Dioxide 1.00 Rezal 36GP Aluminium Tetrachlorohydrex GLY 20.00 Dry Flo C Aluminium Starch Octenyl 22.50 Succinate Hydrolite 5 1,2-pentanediol 0.60 Preservative Phenoxyethanol 0.40 Hexoxy-1.2-propanediol 0.10 Formulation 1 0.40

TABLE-US-00031 TABLE F21 Deodorant pump spray with SymClariol (Amounts in % b.w.) Ingredients INCI Amount SymClariol Decylene Glycol 0.50 Solubilizer PEG-40 Hydrogenated Castor Oil. 4.00 Trideceth-9. Propylene Glycol. Water (Aqua) Neo-PCL Water Trideceth-9. PEG-5 Ethylhexanoate. 1.50 Soluble N Aqua SymRelief Bisabolol. Zingiber Officinale 0.10 (Ginger) Root Extract Water Water (Aqua) Ad 100 1.2 Propylene Glycol Propylene Glycol 6.00 Hydrolite 5 1,2-pentanediol 0.40 SymDiol 68 1.2-Hexanediol. Caprylyl Glycol 0.20 Formulation 1 0.40

TABLE-US-00032 TABLE F22 Antiperspirant formulations (Amounts in % b.w.) Ingredients Amounts Reach AZP-908 SUF 24.00 Cyclomethicone (Pentamer) Ad 100 Polydecene (Silkflo 364 NF) 17.50 Neo Heliopan OS (ethylhexyl salicylate) 2.50 L-Menthyl lactate (Frescolate ML) 0.25 Polyethylene 3.00 Hydrogenated castor oil 2.00 Promyristyl PM-3 7.00 PEG-8 Distearate 3.00 Silicon dioxide (Cab-O-Sil M-5) 1.00 Stearyl alcohol 15.00 Octyldodecanol 0.10 1,2-pentanediol (Hydrolite 5) 0.80 3-Phenylpropanol 0.40 Formulation 1 0.60

TABLE-US-00033 TABLE F23 Deodorant spray with Triclosan (Amounts in % b.w.) Ingredients Amount PEG-40-hydrogenated castor oil 3.00 Ethylhexylglycerol (Octoxyglycerol) 0.80 Ethanol 40.00 Citrate buffer 0.50 Triclosan (5-chloro-2-(2.4-dichlorophenoxy)phenol) 0.25 1,2-pentanediol (Hydrolite 5) 0.75 Phenoxyethanol 0.40 Formulation 1 0.40 Water Ad 100

TABLE-US-00034 TABLE F24 O/W lotion (Amounts in % b.w.) Ingredients Amount Paraffin oil 5.00 Isopropyl palmitate 5.00 Cetyl alcohol 2.00 Beeswax 2.00 Ceteareth-20 2.00 PEG-20-glyceryl stearate 1.50 Glycerol 3.00 1,2-pentanediol (Hydrolite 5) 0.30 Methylparaben 0.30 Formulation 1 0.60 Water ad 100.00

TABLE-US-00035 TABLE F25 Body lotion (Amounts in % b.w.) Ingredients Amount Cetearyl Alcohol 2.00 Ethylhexyl Isononanoate 5.00 Cetearyl Ethylhexanoate. Isopropyl Myristate 3.00 Glyceryl Oleate Citrate. Caprylic/Capric Triglyceride 4.00 Water (Aqua) 79.50 Carbomer 0.30 Sodium Benzoate 0.100 Propylene Glycol 5.00 Sodium Hydroxide 30% solution 0.30 1,2-pentanediol (Hydrolite 5) 0.30 Triethylene Glycol. Imidazolidinyl Urea. 0.30 Methylparaben. Propylparaben. Dehydroacetic Acid Formulation 1 0.20

TABLE-US-00036 TABLE F26 Cream (Amounts in % b.w.) Ingredients Amount Paraffin oil 10.00 Ozokerite 4.00 Vaseline 4.00 Vegetable oil 10.00 Wool wax alcohol 2.00 Aluminum stearate 0.40 1,2-pentanediol (Hydrolite 5) 2.00 Phenoxyethanol 0.50 Formulation 1 0.50 Water ad 100.00

TABLE-US-00037 TABLE F27 Cream (Amounts in % b.w.) Ingredients INCI Amount Dracorin CE Glyceryl Stearate Citrate 1.00 Lanette O Cetearyl Alcohol 2.00 Cutina GMS-V Glyceryl Stearate 1.00 Tegosoft MM Myristyl Myristate 1.00 Xiameter PMX-0246. Cyclohexasiloxane (and) 0.50 Cyclosiloxane Cyclopentasiloxane Dragoxat 89 Ethylhexyl Isononanoate 2.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 4.00 Neutral Oil Caprylic/Capric Triglyceride 4.00 Carbopol Ultrez 21 Acrylates/C10-30 Alkyl 0.20 Acrylate Crosspolymer Keltrol CG-T Xanthan Gum 0.10 Water Water (Aqua) Ad 100 Glycerol 99.5 P. Glycerol 3.00 Propylene Propylene Glycol 2.00 Glycol -1.2 99 P GC Sodium Benzoate Sodium Benzoate 0.10 Sodium Hydroxide Sodium Hydroxide 0.50 10% solution Hydrolite 5 1,2-pentanediol 0.30 Euxyl K702 Dehydroacetic Acid. Benzoic Acid. 0.30 Phenoxyethanol. Polyaminopropyl Biguanide. Ethylhexylglycerin Formulation 1 0.70

TABLE-US-00038 TABLE F28 Hand and body cream (Amounts in % b.w.) Ingredients INCI Amount Dracorin GOC Glyceryl Oleate Citrate. 2.00 Caprylic/Capric Triglyceride PCL-Solid Stearyl Heptanoate. Stearyl Caprylate 2.50 Lanette O Cetearyl Alcohol 1.50 Cutina GMS-V Glyceryl Stearate 1.00 Dragoxat 89 Ethylhexyl Isononanoate 3.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 7.00 Isodragol Triisononanoin 4.00 Xiameter Cyclopentasiloxane (and) 0.50 PMX-0345 Cyclohexasiloxane Cyclosiloxane Water Water (Aqua) Ad 100 Carbopol Acrylates/C10-30 Alkyl Acrylate 0.20 Ultrez 21 Crosspolymer Keltrol CG-RD Xanthan Gum 0.10 Glycerol 85 P. Glycerol 3.00 DragoBetaGlucan Water (Aqua). Butylene Glycol. Glycerol. 1.50 Avena Sativa (Oat) Kernel Extract Potassium Sorbat Potassium Sorbate 0.10 Sodium Hydroxide Sodium Hydroxide 0.50 10% solution Hydrolite 5 1,2-pentanediol 0.20 Euxyl K300 Methyl-. Butyl-. Ethyl-. Propyl. 0.30 Isobutylparaben. Phenoxyethanol. Formulation 1 0.30

TABLE-US-00039 TABLE F29 Face cream (Amounts in % b.w.) Ingredients INCI Amount Emulsiphos Potassium Cetyl Phosphate. 1.50 Hydrogenated Palm Glycerides Cutina GMS-V Glyceryl Stearate 1.70 Lanette O Cetearyl Alcohol 3.00 Tegosoft MM Myristyl Myristate 1.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 1.00 Isodragol Triisononanoin 3.00 Dragoxat 89 Ethylhexyl Isononanoate 4.00 Avocado Oil Persea Gratissima (Avocado) Oil 3.00 Abil 350 Dimethicone 0.50 Covi-ox T-70 Tocopherol 0.10 Edeta BD Disodium EDTA 0.10 Carbopol Ultrez 21 Acrylates/C10-30 Alkyl Acrylate 0.30 Crosspolymer Keltrol CG-RD Xanthan Gum 0.150 Water Water (Aqua) Ad 100 Glycerol 99.5 P. Glycerol 4.00 Propylene Propylene Glycol 3.00 Glycol -1.2 99 P GC SymMatrix Maltodextrin. Rubus Fruticosus 0.50 (Blackberry) Leaf Extract Sodium Hydroxide Sodium Hydroxide 0.50 10% solution Hydrolite 5 1,2-pentanediol 0.30 Euxyl K712 Sodium Benzoate. Potassium Sorbate 0.20 Formulation 1 0.60

TABLE-US-00040 TABLE F30 Moisturizing body care cream (Amounts in % b.w.) Ingredient Amount PEG-7 hydrogenated castor oil 6.00 Cetearyl ethyl hexanoate 10.00 Isopropyl myristate 5.00 Mineral oil 7.00 Shea Butter (Butyrospermum parkii) 0.50 Aluminum stearate 0.50 Magnesium stearate 0.50 Bisabolol 0.20 Quaternium-18-Hectorit 0.70 Dipropylene glycol 5.0 Magnesium sulfate 0.70 1,2-pentanediol (Hydrolite 5) 4.00 Preservative (Phenoxyethanol) 0.20 Formulation 1 0.40 Aqua dem. 58.90

TABLE-US-00041 TABLE F31 Anti-wrinkle cream (Amounts in % b.w.) Ingredients Amount Glyceryl Stearate Citrate 1.00 Glyceryl Laurate 1.00 Cetearyl Alcohol (and) Myristyl Myristate 3.00 Cetearyl Ethylhexanoate 4.00 Mineral oil 4.00 Cyclohexasiloxane 0.50 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 0.20 Water Ad 100 1.2-Hexanediol 2.00 Sodium Hydroxide 10% solution 0.10 Narcissus Tazetta Bulb Extract 1.00 1,2-pentanediol (Hydrolite 5) 0.30 Formulation 1 0.50

TABLE-US-00042 TABLE F32 Functional skin oil for disinfection (Amounts in % b.w.) Ingredients INCI Amount Neutral Oil Caprylic/Capric Triglyceride Ad 100 Sweet Almond Oil Prunus Dulcis 20.00 Dragoxat 89 Ethylhexyl Isononanoate 4.00 Isopropyl Palmitate Isopropyl Palmitate 6.00 PCL-Liquid 100 Cetearyl Ethylhexanoate 15.00 Dragosantol 100 Bisabolol 0.20 Retinyl Acetate In Retinyl Acetate 0.50 Oil (1 Mio. le/G) Vitamin E Acetate Tocopheryl Acetate 0.50 Covi-ox T-70 Tocopherol 0.10 Hydrolite 5 1,2-pentanediol 0.30 Preservative Methyl-. Butyl-. Ethyl-. Propylparaben 0.30 Formulation 1 0.40

TABLE-US-00043 TABLE F33 Septic wound cream (Amounts in % b.w.) Ingredients (INCI) Amount Sorbitan Isostearate. Hydrogenated Castor Oil. Ceresin. 6.00 Beeswax (Cera Alba) Petrolatum 21.00 Cera Alba 5.00 Cetearyl Alcohol 7.00 Prunus Dulcis 7.00 Lanolin 5.00 Paraffinum Liquidum 12.00 Water (Aqua) Ad 100 Panthenol 7.00 Magnesium Sulfate 0.70 1,2-pentanediol (Hydrolite 5) 1.00 Tocopheryl Acetate 1.00 Octenidine dihydrochloride 0.10 Phenoxyethanol 0.50 Formulation 1 0.50

TABLE-US-00044 TABLE F34 Moisturizing and disinfecting face mask (Amounts in % b.w.) Ingredients INCI Amount Water Water (Aqua) Ad 100 Stabileze QM PVM / Ma Decadiene Crosspolymer 0.50 Biotive L-Arginine Arginine 0.75 Actipone Laminaria Glycerol. Water (Aqua). Laminaria 1.00 Saccharina GW Saccharina Extract Extrapone Water (Aqua). Propylene Glycol. 1.00 Cucumber Cucumis Sativus (Cucumber) Juice Glycerol 99.5 P. Glycerol 7.00 Neo Actipone Sapindus Mukurossi Peel Extract 0.50 Soap Nutshell Colour I Colour 0.01 Hydrolite 5 Pentylene Glycol 5.00 Solubilizer PEG-40 Hydrogenated Castor Oil. 0.60 Trideceth-9. Water (Aqua) Hydrolite 5 1,2-pentanediol 0.08 Preservative Phenoxyethanol 0.40 Formulation 1 0.40

TABLE-US-00045 TABLE F35 Sprayable disinfecting gel (Amounts in % b.w.) Ingredients INCI Amount Water Water (Aqua) Ad 100 Stabileze QM PVM / Ma Decadiene Crosspolymer 0.25 Sodium Hydroxide Sodium Hydroxide 0.40 10% solution Coffein pure Caffeine 0.50 Extrapone Horse Propylene Glycol. Water (Aqua). 1.00 Chestnut Glucose. Aesculus Hippocastanum (Horse Chestnut) Seed Extract. Lactic Acid Hydrolite 5 1,2-pentanediol 3.00 1.3 Butylene Glycol Butylene Glycol 5.00 Biotive Esculin Esculin 0.30 Sesquihydrate Ethanol 96% Alcohol Denat. 10.00 Solubilizer PEG-40 Hydrogenated Castor Oil. 0.50 Trideceth-9. Water (Aqua) Preservative Phenoxyethanol 0.70 Formulation 1 0.30

TABLE-US-00046 TABLE F36 Mineral wash and cleaning gel (Amounts in % b.w.) Ingredients INCI Amount Water Water (Aqua) Ad 100 Pionier NP 37 G Sodium Carbomer 1.50 SymSol PF-3 Water (Aqua). Pentylene Glycol. Sodium Lauryl 5.00 Sulfoacetate. SodiumOleoyl Sarcosinate. Sodium Chloride. Disodium Sulfoacetate. SodiumOleate. Sodium Sulfate Hydroviton 24 Water (Aqua). Pentylene Glycol. Glycerol. 1.00 Sodium Lactate. Lactic Acid. Serine. Urea. Sorbitol. Sodium Chloride. Allantoin Extrapone Silk GW Water (Aqua). Glycerol. Hydrolyzed Silk 1.00 Hydrolite 5 Green Hydrolite 5 Green 4.00 Actipearls Red Star # DH10402/6 Water (Aqua). Propylene Glycol. Algin. Gellan 1.00 Gum. Xanthan Gum. CalciumChloride. CI 12490 (Pigment Red 5). Mica (CI 77019). Titanium Dioxide (CI 77891) 1,2-pentanediol (Hydrolite 5) 1,2-pentanediol 0.50 3-Phenylpropanol 0.70 Formulation 1 0.30

TABLE-US-00047 TABLE F37 Anti-acne wash (Amounts in % b.w.) Ingredients (INCI) Amount Water (Aqua) 45.70 Polyquaternium-7 0.50 Cocamidopropyl Betaine 9.000 9.00 Coco Glucoside 2.000 2.00 Polysorbate 80. Glycerol. Gossypium Herbaceum. (Cotton) Seed 1.00 Oil. Water (Aqua) Trideceth-9. PEG-5 Ethylhexanoate. Water (Aqua) 1.00 Glycereth-90 Isostearate. Laureth-2 0.50 Sodium Laureth Sulfate 37.000 37.00 Glycerol. Triticum Vulgare (Wheat) Gluten. Water (Aqua) 1.00 Sodium Chloride 0.30 1,2-pentanediol (Hydrolite 5) 1.00 Formulation 1 0.50

TABLE-US-00048 TABLE F38 Cosmetic sun protection composition (Amounts in % b.w.) Ingredient Amount Ethylhexyl cinnamic acid 7.50 Benzophenon-3 2.00 Polyglyceryl dimer soyate 0.80 Sorbitane stearate 1.00 Tocopheryl acetate 0.50 Glyceryl stearate. PEG-100 Stearate 3.00 PEG-40. hydrogenated castor oil 1.00 Titanium dioxide. aluminum oxide hydrate. 3.00 Dimethicon/Methicon Copolymer Butyrospermum parkii (Shea Butter) 1.00 C.sub.12-15 alkyl benzoate 6.50 Butylene glycol 5.00 Xanthan gum 0.30 Disodium EDTA 0.10 Allantoin 0.10 Polyacryl amide. C.sub.13-14 isoparaffin. Laureth-7 1.00 1,2-pentanediol (Hydrolite 5) 5.00 4-t Butylcyclohexanol 1.00 Preservatives (Methyl-. Butyl-. Ethyl-. Propylparaben. 0.30 Phenoxyethanol) Formulation 1 0.60 Aqua dem. Ad 100

TABLE-US-00049 TABLE F39 Sun protection spray (Amounts in % b.w.) Ingredients INCI Amount Water. demineralized Water (aqua) 69.50 Glycerol Glycerol 4.00 1.3 butylene glycol Butylene glycol 5.00 D-Panthenol Panthenol 0.50 Lara Care A-200 Galactoarabinan 0.25 Baysilone oil M 10 Dimethicone 1.00 Edeta BD Disodium EDTA 0.10 Copherol 1250 Tocopheryl acetate 0.50 Cetiol OE Dicaprylyl ether 3.00 Neo Heliopan HMS Homosalate 5.00 Neo Heliopan AV Ethylhexyl methoxycinnamate 6.00 Neo Heliopan 357 Butyl methoxydibenzoylmethane 1.00 Corapan TQ Diethylhexylnaphthalate 2.00 Alpha Bisabolol Bisabolol 0.10 Pemulen TR-2 Acrylates/C10-30 alkyl acrylate 0.25 crosspolymer NaOH. 10% Sodium hydroxide 0.60 Hydrolite 5 1,2-pentanediol 0.20 Phenoxyethanol Phenoxyethanol 0.40 Solbrol M Methylparaben 0.10 Solbrol P Propylparaben 0.10 Formulation 1 0.50

TABLE-US-00050 TABLE F40 Sunscreen spray O/W. SPE 15-20 (Amounts in % b.w.) Ingredients INCI Amount Dracorin GOC Glyceryl Oleate Citrate. 2.00 Caprylic/Capric Triglyceride Corapan TQ Diethylhexyl 2.6-Naphthalate 3.00 Neo Heliopan HMS Homosalate 7.00 Neo Heliopan OS Ethylhexyl Salicylate 5.00 Neo Heliopan 357 Butyl Methoxydibenzoylmethane 3.00 Isoadipate Diisopropyl Adipate 6.00 Baysilone Oil M10 Dimethicone 1.00 Edeta BD Disodium EDTA 0.10 Vitamin E Acetate Tocopheryl Acetate 0.50 Dragosantol 100 Bisabolol 0.10 Pemulen TR-2 Acrylates/C10-30 Alkyl Acrylate 0.25 Crosspolymer Water Water (Aqua) Ad 100 Glycerol 99.5 P. Glycerol 4.00 Butylene Glycol Butylene Glycol 5.00 Neo Heliopan Phenylbenzimidazole 8.00 Hydro (103089). used as 25% aq. solution Sulfonic Acid Biotive L-Arginine Arginine 0.55 Hydrolite 5 1,2-pentanediol 0.40 Sobrol M Methylparaben 0.30 Formulation 1 0.60

TABLE-US-00051 TABLE F41 Sun protection soft cream (W/O). SPF 40 (Amounts in % b.w.) Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 5.00 dipolyhydroxystearate Copherol 1250 Tocopheryl acetate 0.50 Permulgin 3220 Ozocerite 0.50 Zinc stearate Zinc stearate 0.50 Tegosoft TN C12-15 Alkyl benzoate 10.00 Neo Heliopan E1000 Isoamyl-p-methoxycinnamate 2.00 Neo Heliopan 303 Octocrylene 5.00 Neo Heliopan MBC 4-Methylbenzylidene camphor 3.00 Zinc oxide. neutral Zinc oxide 5.00 Water. distilled Water (aqua) Add 100 EDETA BD Disodium EDTA 0.10 Glycerol Glycerol 4.00 Magnesium sulfate Magnesium sulfate 0.50 Hydrolite 5 1,2-pentanediol 0.30 Symdiol 68 1.2-Hexanediol. Caprylylglycol 0.30 Formulation 1 0.80

TABLE-US-00052 TABLE F42 Sun protection milk (W/O) (Amounts in % b.w.) Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 3.00 dipolyhydroxystearate Beeswax 8100 Beeswax 1.00 Monomuls 90-0-18 Glyceryl oleate 1.00 Zinc stearate Zinc stearate 1.00 Cetiol SN Cetearyl isononanoate 5.00 Cetiol OE Dicaprylyl ether 5.00 Tegosoft TN C12-15 alkyl benzoate 4.00 Vitamin E Tocopherol 0.50 Neo Heliopan OS Ethylhexyl salicylate 5.00 Neo Heliopan AV Ethylhexyl methoxycinnamate 7.50 Uvinul T150 Ethylhexyl triazone 1.50 Water. distilled Water (Aqua) To 100 Trilon BD Disodium EDTA 0.10 Glycerol Glycerol 5.00 Neo Heliopan Disodium phenyl 15.00 AP 10% solution. dibenzimidazole neutralized with NaOH tetrasulfonate Hydrolite 5 1,2-pentanediol 0.25 Alpha bisabolol Bisabolol 0.10 SymOcide PT Phenoxyethanol. Tropolone 0.25 Formulation 1 0.25

TABLE-US-00053 TABLE F43 After sun gel (Amounts in % b.w.) Ingredients INCI Amount SymSol PF-3 Water (Aqua). Pentylene Glycol. Sodium Lauryl 3.000 Sulfoacetate. SodiumOleoyl Sarcosinate. Sodium Chloride. Disodium Sulfoacetate. SodiumOleate. Sodium Sulfate Glycerol 99.5 P. Glycerol 5.000 SymHelios 1031 Benzylidene Dimethoxydimethylin danone 0.100 Water Water (Aqua) Ad 100 Pemulen TR-2 Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1.000 D-Panthenol 75 W Panthenol 0.500 SymFinity 1298 Echinacea Purpurea Extract 0.100 Extrapone Pearl GW Water (Aqua). Glycerol. Hydrolyzed Pearl. 1.000 Xanthan Gum Sodium Hydroxide 10% solution Sodium Hydroxide 2.500 Ethanol 96% Alcohol Denat. 15.000 Hydrolite 5 1,2-pentanediol 0.20 SymOcide PS Phenoxyethanol. 1.2-Hexanediol. 0.50 Decyleneglycol Formulation 1 0.50

TABLE-US-00054 TABLE F44 After sun lotion (Amounts in % b.w.) Ingredients Amount Acrylate/C10-30 alkylacrylate crosspolymer 0.4 Cetearylethyl hexanoate 15.0 Bisabolol 0.2 Tocopheryl acetate 1.0 Panthenol 1.0 Alcohol 15.0 Glycerol 3.0 1.2-Hexanediol 0.60 Formulation 1 0.30 1,2-pentanediol (Hydrolite 5) 4.0 Aqua dem. Ad 100 Triethanolamine 0.2

TABLE-US-00055 TABLE F45 Hair styling gel (Amounts in % b.w.) Ingredients Amount Water Ad 100 PVM/MA Decadiene Crosspolymer 0.60 PVP 3.00 Isocetyl Stearate 4.00 Ethylhexyl Methoxycinnamate 0.50 Aminomethyl Propanol 0.40 1,2-pentanediol (Hydrolite 5) 0.60 SymDiol 68T (1.2-Hexanediol. 1.2-Octanediol. Tropolone) 0.30 Phenoxyethanol 0.20 Formulation 1 0.40

TABLE-US-00056 TABLE F46 Silicone emulsion (Amounts in % b.w.) Ingredients Amount Potassium Cetyl Phosphate. Hydrogenated Palm Glycerides 1.00 Cyclohexasiloxane 4.00 Cetearyl Alcohol 1.50 Phenyl Trimethicone 3.00 Stearyl Heptanoate. Stearyl Caprylate 3.00 Dimethicone 1.00 Xanthan Gum 0.20 Isoamyl p-Methoxycinnamate 5.00 Water Ad 100 Methylpropanediol 3.00 1,2-pentanediol (Hydrolite 5) 0.30 Diazolidinyl urea 0.10 Formulation 1 0.50

TABLE-US-00057 TABLE F47 Microemulsion gel (Amounts in % b.w.) Ingredient Amount Glycerol isostearate 1.80 Octoxyglycerol 1.00 Ceteareth-15 5.20 PEG-150 Distearate 1.00 Aluminium chlorohydrate 5.00 Isotridecylisononanoate 3.30 Cyclomethicone 6.60 1,2-pentanediol (Hydrolite 5) 0.70 Euxyl K145 (Methylchloroisothiazolinone. 0.10 Methylisothiazlinone. Bronopol) Formulation 1 0.40 Water Ad 100

TABLE-US-00058 TABLE F48 Air freshener in gel form (Amounts in % b.w.) Ingredient Amount Demineralised water Ad 100 Genugel X-6424 (carrageenan) 2.00 Arkopal N 100 or Tergitol NP 10 (Emulsifer) 3.50 1,2-pentanediol (Hydrolite 5) 0.60 Preventol D 7 (5-chloro-2-methyl-4-isothiazolin- 0.10 3-one. 2-methyl-2H isothiazol-3-one) Formulation 1 0.80

TABLE-US-00059 TABLE F49 Cleaner. APC liquid. alkaline pH 8-10 (Amounts in % b.w.) Ingredients (INCI) Amount Aqua 59.06 Tri Sodium Citrate Dihydrate 3.00 Sodium Laureth Sulfate 30.00 Trideceth-9 5.00 Ethanol 2.00 Citric Acid 10% solution 0.24 1,2-pentanediol (Hydrolite 5) 0.50 Mixture of 5-Chloro-2-methyl-2H-isothiazol- 0.10 3-one and 2-Methyl-2H-isothiazol-3-one Formulation 1 0.30

TABLE-US-00060 TABLE F50 Fabric softener (Amounts in % b.w.) Ingredients (INCI) Amount Aqua 72.10 Dialkylester ammomium methosulfate 16.60 Polydimethylsiloxane 0.30 Magnesiumchloride 10.00 1,2-pentanediol (Hydrolite 5) 0.60 Mixture of 5-Chloro-2-methyl-2H-isothiazol- 0.10 3-one and 2-Methyl-2H-isothiazol-3-one Formulation 1 0.40

TABLE-US-00061 TABLE F51 Liquid detergent (Amounts in % b.w.) Ingredients Amount Deionized water 39.60 Optical brightener 0.10 Coconut fatty acids (C12-C18) 7.50 Potassium hydroxide 50% solution 4.30 Propane-1.2-diol 5.00 Fatty alcohols C12-C15. 8 EO 12.00 Na-salt of secondary alkyl sulfonates (C13-C17) 17.00 Triethanolamine 2.00 Trisodium citrate dihydrate 5.00 Dequest 2066 Diethylenetriamine 3.00 penta(methylene phosphonic acid) Ethanol 3.00 Enzymes 0.70 1,2-pentanediol (Hydrolite 5) 0.50 Formulation 1 1.00

TABLE-US-00062 TABLE F52 Liquid detergent concentrate (Amounts in % b.w.) Ingredients Amount Deionized water 12.9 Coconut fatty acids (C12-C18) 10.0 Fatty alcohols C12-C15. 8 EO 26.0 Na-salt of secondary alkyl sulfonates (C13-C17) 26.5 Triethanol amine 8.5 Na-salt of fatty alcohol sulfates C12-C14 3.0 Ethanol 5.5 Urea 4.5 Enzymes 0.9 Citric acid 1.0 1,2-pentanediol (Hydrolite 5) 0.7 Formulation 1 0.8

TABLE-US-00063 TABLE F53 Toilet cleaner (Amounts in % b.w.) Ingredients Amount Water 93.0 Kelzan ASX-T 0.5 Parafin sulfonate. sodium salt 1.0 Citric acid 5.0 Colorant (FD & C Yellow No. 6) 0.1 1,2-pentanediol (Hydrolite 5) 0.3 Preservative (Benzisothiazolinone. Glutaral) 0.05 Formulation 1 0.6

TABLE-US-00064 TABLE F54 Dish washing concentrate (Amounts in % b.w.) Ingredients Amount Sodium laurylsulfate 31.0 Propane-1.2-diole 6.0 Ethyl alcohol 96% 7.0 Palm tree glucosides 6.0 Coco betaine 18.0 1,2-pentanediol (Hydrolite 5) 0.4 Formulation 1 0.5 Water 31.6

TABLE-US-00065 TABLE F55 Dish washing concentrate (Amounts in % b.w.) Ingredients Amount Palm tree glucosides 4.0 Sodium lauryl sulfate 45.0 Coco betaine 8.0 Ethyl alcohol 96% 1.0 Colorant (C.I. Pigment Blue 15) 0.05 1,2-pentanediol (Hydrolite 5) 0.2 Formulation 1 0.7 Water Ad 100

TABLE-US-00066 TABLE F56 Solution for wet wipes (Amounts in % b.w.) Ingredients INCI Amount SymSol PF-3 Water (Aqua). Pentylene Glycol. Sodium Lauryl 2.00 Sulfoacetate. SodiumOleoyl Sarcosinate. Sodium Chloride. Disodium Sulfoacetate. SodiumOleate. Sodium Sulfate Dragosantol 100 Bisabolol 0.10 Glycerol 99.5 P. Glycerol 5.00 Water Water (Aqua) Ad 100 Hydrolite 5 1,2-pentanediol 5.00 D-Panthenol 75 W Panthenol 0.80 DragoCalm Water (Aqua). Glycerol. Avena Sativa (Oat) 1.00 Kernel Extract Witch Hazel-Distillate Hamamelis Virginiana (Witch Hazel) Water. 1.00 Water (Aqua). Alcohol Allplant Essence Org. Pelargonium Graveolens Flower/Leaf/Stem 1.00 Rose Geranium P Water Preservative Phenoxyethanol 0.30 Formulation 1 0.50