Abstract
According to some aspects, an x-ray source is provided. The x-ray source comprises an electron source configured to generate electrons, a primary target arranged to receive electrons from the electron source to produce broadband x-ray radiation in response to electrons impinging on the primary target, a secondary to produce monochromatic x-ray radiation via fluorescence in response to absorbing incident broadband x-ray radiation emitted by the primary target, an x-ray window positioned between the primary target and the secondary target that allows broadband x-ray radiation to pass through the x-ray window to impinge on the secondary target, and an electron shield positioned between the primary target and the x-ray window to absorb electrons back-scattered from the primary target to prevent the back-scattered electrons from impinging on the x-ray window.
Claims
1. An x-ray source comprising: an electron source configured to generate electrons; a primary target arranged to receive electrons from the electron source to produce broadband x-ray radiation in response to electrons impinging on the primary target; a secondary to produce monochromatic x-ray radiation via fluorescence in response to absorbing incident broadband x-ray radiation emitted by the primary target; an x-ray window positioned between the primary target and the secondary target that allows broadband x-ray radiation to pass through the x-ray window to impinge on the secondary target; and an electron shield positioned between the primary target and the x-ray window to absorb electrons back-scattered from the primary target to prevent the back-scattered electrons from impinging on the x-ray window.
2. The x-ray source of claim 1, further comprising a heat sink component thermally coupled to the primary target to dissipate heat generated by electrons impinging on the primary target.
3. The x-ray source of claim 2, wherein the heat sink component is thermally coupled to the electron shield to dissipate heat generate by electrons impinging on the primary target.
4. The x-ray source of claim 2, wherein the heat sink component is thermally coupled to the x-ray window to dissipate heat from the x-ray window.
5. The x-ray source of claim 3, wherein the electron shield includes a first portion positioned between the primary target and the x-ray source to absorb back-scattered electrons and a second portion positioned between the primary target and the heat sink component, the second portion disposed in thermal contact with the heat sink component and the primary contact.
6. The x-ray source of claim 5, wherein the heat sink component has a conduit formed therein for circulating coolant to absorb heat from the primary target, the x-ray window and the electron shield.
7. The x-ray source of claim 1, wherein the electron shield is formed at least in part of graphite.
8. The x-ray source of claim 1, wherein the x-ray window is formed at least in part of beryllium.
9. The x-ray source of claim 1, wherein the primary target is formed at least in part of tungsten.
10. The x-ray source of claim 2, wherein the heat sink component is formed at least in part of copper.
11. The x-ray source of claim 2, further comprising a vacuum chamber, wherein the electron source, the primary target and the electron shield are positioned within the vacuum chamber, wherein the x-ray window provides an interface between the vacuum chamber and the atmosphere, and the secondary target is positioned outside the vacuum chamber.
12. The x-ray source of claim 11, wherein the x-ray window provides a receptacle to accommodate the secondary target outside the vacuum chamber.
13. The x-ray source of claim 11, wherein the electron shield covers the x-ray window within the vacuum chamber, and wherein the electron shield includes at least one opening that allows air between the electron shield and the x-ray window to be pumped out of the vacuum chamber when the vacuum chamber is evacuated.
14. The x-ray source of claim 12, wherein the heat sink component comprises a first side positioned within the vacuum chamber and a second side external to the vacuum chamber, wherein the first side includes a first recess formed therein that accommodates the primary target and that provides a contact surface for the x-ray window and the electron shield, and wherein the heat sink component further comprises a first passage formed through the heat sink from the first side to the second side through which the secondary target can be positioned within the receptacle formed by the x-ray window.
15. The x-ray source of claim 14, further comprising a collimator.
16. The x-ray source of claim 15, wherein the second side of the heat sink component includes a second recess to accommodate the collimator, and wherein the first passage connects the first recess and the second recess.
17. The x-ray source of claim 16, wherein the collimator is configured to be removably attached to the second side of the heat sink.
18. The x-ray source of claim 17, wherein the collimator comprises a plurality of stacked annular disks formed of a blocking material wherein the annulus of the stacked discs forms a second passage through the collimator.
19. The x-ray source of claim 18, wherein the secondary target is housed within a removeable carrier, the removeable carrier including a first portion having a third passage formed therethrough and a second portion configured for insertion through the first passage to position the secondary target within the receptacle of the x-ray window.
20. The x-ray source of claim 19, wherein the second recess is configured to accommodate the first portion of the carrier, and wherein when the carrier has been inserted into the first passage and the collimator has been positioned within the second recess, the third passage formed through the first portion of the carrier aligns with the second passage formed through the collimator to provide the exit aperture of the x-ray source.
21. The x-ray source of claim 1, further comprising a power supply configured to supply at least 10 kilowatts of power.
22. The x-ray source of claim 21, wherein the electron source comprises a cathode and wherein the power supply is configured to apply a negative voltage to the cathode.
23. The x-ray source of claim 22, wherein the power supply is configured to apply a voltage potential between the cathode and the primary target of between 60 kilovolts and 80 kilovolts and the cathode is configured to emit between 160 milliamps and 200 milliamps of electrons.
24-53. (canceled)
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0024] Various aspects and embodiments of the disclosed technology will be described with reference to the following figures. It should be appreciated that the figures are not necessarily drawn to scale.
[0025] FIG. 1 illustrates a schematic of a broadband x-ray source;
[0026] FIG. 2. illustrates the scenario in which an electron (much lighter than the nucleus) comes very close to the nucleus and the electromagnetic interaction causes a deviation of the trajectory where the electron loses energy and an X-ray photon is emitted and describes Bremsstralung in its simplest form;
[0027] FIG. 3 illustrates the Bremsstrahlung spectrum produced by a typical X-ray tube, wherein the lower energy x-rays trying to escape the target are absorbed causing the characteristic roll over of the spectrum at low energies;
[0028] FIG. 4 illustrates the physical phenomenon that generates characteristic line emissions;
[0029] FIG. 5 illustrates the combined spectrum from an X-ray tube with a molybdenum anode showing the thick target Bremsstrahlung and the characteristic molybdenum line emission;
[0030] FIG. 6A illustrates the photoelectric effect;
[0031] FIG. 6B illustrates the principle of X-Ray fluorescence from the K shell;
[0032] FIG. 7 illustrates the absorption coefficient as a function of x-ray energy for tin, wherein the discontinuous jumps or edges show how the absorption is enhanced just above the binding energies of the electrons in tin;
[0033] FIG. 8 illustrates an X-Ray fluorescence spectrum made by irradiating a target of aluminum (Al) with copper x-rays which were generated by an x-ray tube with an anode of copper;
[0034] FIG. 9 illustrates an x-ray apparatus for generating monochromatic x-rays;
[0035] FIGS. 10A and 10B illustrate on-axis and off-axis x-ray spectra of x-ray radiation emitted from a conventional monochromatic x-ray apparatus;
[0036] FIG. 11A illustrates a monochromatic x-ray device, in accordance with some embodiments;
[0037] FIG. 11B illustrates a zoomed in view of components of the monochromatic x-ray device illustrated in FIG. 11A;
[0038] FIG. 11C illustrates a zoomed in view of components of the monochromatic x-ray device illustrate in FIG. 11A using a hybrid material interface portion, in accordance with some embodiments;
[0039] FIG. 12 illustrates a removeable carrier configured to be inserted and capable of being removed from a receptacle of a monochromatic x-ray device;
[0040] FIGS. 13A, 13B and 13C illustrate views of a secondary target carrier, in accordance with some embodiments;
[0041] FIGS. 14A and 14B illustrate on-axis and off-axis x-ray spectra of x-ray radiation emitted from a monochromatic x-ray apparatus using the exemplary carrier illustrated in FIGS. 13A, 13B and 13C;
[0042] FIG. 14C illustrates field of view characteristic of the x-ray spectra illustrated in FIGS. 10A-B and FIGS. 14A-14B;
[0043] FIG. 15 illustrates integrated power ratios in the low and high energy spectra as a function of viewing angle;
[0044] FIG. 16 illustrates monochromaticity as a function of viewing angle;
[0045] FIGS. 17A, 17B and 17C illustrate views of a secondary target carrier, in accordance with some embodiments;
[0046] FIGS. 18A and 18B illustrate on-axis and off-axis x-ray spectra of x-ray radiation emitted from a monochromatic x-ray apparatus using the exemplary carrier illustrated in FIGS. 17A, 17B and 17C;
[0047] FIG. 19 illustrate fluorescent x-ray spectra of secondary targets of four exemplary materials;
[0048] FIG. 20 illustrates x-ray intensity as a function of emission current for a number of primary voltages for secondary targets of two different geometries;
[0049] FIG. 21 illustrates the x-ray spectrum emitted from a gold primary target;
[0050] FIG. 22 illustrates on-axis and off-axis monochromaticity as a function of primary voltage for a tin secondary target using the carrier illustrated in FIGS. 17A, 17B and 17C;
[0051] FIG. 23 illustrates on-axis and off-axis monochromaticity as a function of primary voltage for a silver secondary target using the carrier illustrated in FIGS. 17A, 17B and 17C;
[0052] FIGS. 24A and 24B illustrate a cross-section of a monochromatic x-ray source 2400 with improved electron optics, in accordance with some embodiments;
[0053] FIG. 25 illustrate the locus of points where the electrons strike the primary target in the monochromatic x-ray source illustrated in FIGS. 24A and 24B;
[0054] FIG. 26 illustrate the locus of points where the electrons strike the primary target in the monochromatic x-ray source illustrated in FIGS. 24A and 24B.
[0055] FIG. 27 illustrates a monochromatic x-ray source including a hybrid interface component;
[0056] FIG. 28 illustrates an alternative configuration in which the cathode is moved further away from the primary target, resulting in divergent electron trajectories and reduced monochromaticity.
[0057] FIG. 29 illustrates a mammographic phantom used to perform imaging experiment using monochromatic x-ray sources described herein;
[0058] FIG. 30 illustrates histograms of the embedded linear array of blocks of the phantom illustrated in FIG. 29;
[0059] FIG. 31 illustrates images of the phantom in FIG. 29 using a commercial broadband x-ray system and a monochromatic x-ray system according to some embodiments, along with corresponding histograms;
[0060] FIG. 32 illustrates stacked mammographic phantoms to model thick breast tissue;
[0061] FIG. 33 illustrates images of the phantom in FIG. 32 using a commercial broadband x-ray system and a monochromatic x-ray system according to some embodiments, along with corresponding histograms;
[0062] FIG. 34 illustrates conventional broadband mammography versus monochromatic mammography according to some embodiments;
[0063] FIG. 35 illustrates images of micro-calcifications using a commercial broadband x-ray system and a monochromatic x-ray system according to some embodiments, along with corresponding histograms;
[0064] FIG. 36 illustrates images of micro-calcifications using a commercial broadband x-ray system and a monochromatic x-ray system according to some embodiments, along with corresponding histograms;
[0065] FIG. 37 illustrates line resolutions for different secondary targets and a commercial broadband x-ray system;
[0066] FIG. 38 illustrates the modulation transfer function (MTF) for the monochromatic instrument;
[0067] FIG. 39 illustrates power requirements needed for desired signal to noise ratios for different exposure times and cone geometries;
[0068] FIG. 40 illustrates power requirements needed for desired signal to noise ratios for different exposure times and cone geometries and with an indication of a commercial machine;
[0069] FIG. 41 illustrates schematically fluorescent x-rays emitted from and absorbed by a solid secondary target;
[0070] FIG. 42 illustrates a layered secondary target, in accordance with some embodiments;
[0071] FIG. 43 illustrates the physics of x-ray transmission and absorption;
[0072] FIGS. 44A and 44B illustrate plots of fluorescent x-ray emission versus material thickness for a number of energies;
[0073] FIGS. 45A and 45B illustrate layered secondary targets used in corresponding simulations and experiments;
[0074] FIG. 46 illustrates simulated fluorescent x-ray emissions from the secondary target illustrated in FIG. 45A and a solid secondary target;
[0075] FIG. 47 illustrates measured fluorescent x-rays emissions from the secondary target illustrated in FIG. 45B and a solid secondary target;
[0076] FIG. 48 illustrates a conical shell secondary target, in accordance with some embodiments;
[0077] FIGS. 49A and 49B illustrate nested conical shell secondary targets, in accordance with some embodiments;
[0078] FIGS. 50A and 50B illustrate nested conical and/or frustoconical shell secondary targets, in accordance with some embodiments;
[0079] FIG. 51-53 illustrate layered secondary targets having inverted and/or open geometries, in accordance with some embodiments;
[0080] FIGS. 54A-54C illustrate cylindrical shell secondary targets, in accordance with some embodiments;
[0081] FIGS. 55A-55C illustrate spiral shell secondary targets, in accordance with some embodiments;
[0082] FIGS. 56-59 illustrate layered secondary targets having open proximal ends, in accordance with some embodiments;
[0083] FIGS. 60A-60F illustrate layered shell secondary targets, in accordance with some embodiments;
[0084] FIGS. 61A-61C illustrate layered open shell secondary targets, in accordance with some embodiments;
[0085] FIG. 62 illustrates the relative fluorescent x-ray output from a number of exemplary geometries, in accordance with some embodiments;
[0086] FIGS. 63A and 63B illustrate an exemplary support for a layered secondary target, in accordance with some embodiments;
[0087] FIGS. 64 and 65 illustrate exemplary layered secondary targets positioned within a carrier, in accordance with some embodiments;
[0088] FIGS. 66A and 66B illustrate a carrier for a layered secondary target, in accordance with some embodiments;
[0089] FIG. 67 illustrates curves of fluorescent x-ray flux versus emission current for a number of secondary target geometries and cathode-anode voltage potentials, in accordance with some embodiments;
[0090] FIGS. 68-71 illustrate power requirements versus signal to noise ratio for a number of secondary target geometries, in accordance with some embodiments;
[0091] FIG. 72 illustrates the mass absorption coefficient curve for iodine;
[0092] FIG. 73 illustrates an example of contrast enhanced imaging using Ag K x-rays at 22 keV and an iodine contrast agent called Oxilan 350;
[0093] FIG. 74A-74C illustrate exemplary x-ray sources configured for high-power operation, in accordance with some embodiments;
[0094] FIGS. 75A-75C illustrate views of an exemplary primary target, in accordance with some embodiments;
[0095] FIGS. 75D-75E illustrate an exemplary method of coupling a primary target is to a heat sink component, in accordance with some embodiments;
[0096] FIGS. 76A-76B illustrate views of an exemplary heat sink component, in accordance with some embodiments;
[0097] FIGS. 77A-77D illustrate view of an exemplary electron shield, in accordance with some embodiments;
[0098] FIGS. 77E-77F illustrate an exemplary method of coupling the electron shield to a heat sink component and securing the shield in place, in accordance with some embodiments;
[0099] FIGS. 78A-78C illustrate views of an exemplary x-ray window, in accordance with some embodiments;
[0100] FIGS. 78D-78E illustrate an exemplary method of attaching the x-ray window to the heat sink component, in accordance with some embodiments;
[0101] FIGS. 79A-79C illustrate views of an exemplary collimator, in accordance with some embodiments;
[0102] FIG. 79D illustrates a exemplary method of inserting and positioning the collimator and a secondary target, in accordance with some embodiments;
[0103] FIG. 80A illustrates an external view of an x-ray source, in accordance with some embodiments;
[0104] FIG. 80B illustrates a view of a power supply interface connection, in accordance with some embodiments;
[0105] FIGS. 81A-81C illustrate calculated heating and cooling curves for an exemplary x-ray source, in accordance with some embodiments;
[0106] FIG. 82 illustrates manufacturer calculated heating and cooling curves for a commercial broadband x-ray source;
[0107] FIG. 83 illustrates measured heating and cooling curves for a prototype x-ray source, in accordance with some embodiments;
[0108] FIG. 84 illustrate images of a breast phantom obtained using a commercial broadband x-ray source and a prototype monochromatic x-ray source, in accordance with some embodiments; and
[0109] FIG. 85 illustrates signal-to-ratio curves versus radiation dose for a exemplary monochromatic x-ray source and a conventional broadband source for 4.5 cm and 9 cm breast material.
DETAILED DESCRIPTION
[0110] As discussed above, conventional x-ray systems capable of generating monochromatic radiation to produce diagnostic images are typically not suitable for clinical and/or commercial use due to the prohibitively high costs of manufacturing, operating and maintaining such systems and/or because the system footprints are much too large for clinic and hospital use. As a result, research with these systems are limited in application to investigations at and by the relatively few research institutions that have invested in large, complex and expensive equipment.
[0111] Cost effective monochromatic x-ray imaging in a clinical setting has been the goal of many physicists and medical professionals for decades, but medical facilities such as hospitals and clinics remain without a viable option for monochromatic x-ray equipment that can be adopted in a clinic for routine diagnostic use.
[0112] The inventor has developed methods and apparatus for producing selectable, monochromatic x-radiation over a relatively large field-of-view (FOV). Numerous applications can benefit from such a monochromatic x-ray source, in both the medical and non-medical disciplines. Medical applications include, but are not limited to, imaging of breast tissue, the heart, prostate, thyroid, lung, brain, torso and limbs. Non-medical disciplines include, but are not limited to, non-destructive materials analysis via x-ray absorption, x-ray diffraction and x-ray fluorescence. The inventor has recognized that 2D and 3D X-ray mammography for routine breast cancer screening could immediately benefit from the existence of such a monochromatic source.
[0113] According to some embodiments, selectable energies (e.g., up to 100 kev) are provided to optimally image different anatomical features. Some embodiments facilitate providing monochromatic x-ray radiation having an intensity that allows for relatively short exposure times, reducing the radiation dose delivered to a patient undergoing imaging. According to some embodiments, relatively high levels of intensity can be maintained using relatively small compact regions from which monochromatic x-ray radiation is emitted, facilitating x-ray imaging at spatial resolutions suitable for high quality imaging (e.g., breast imaging). The ability to generate relatively high intensity monochromatic x-ray radiation from relatively small compact regions facilitates short, low dose imaging at relatively high spatial resolution that, among other benefits, addresses one or more problems of conventional x-ray imaging systems (e.g., by overcoming difficulties in detecting cancerous lesions in thick breast tissue while still maintaining radiation dose levels below the limit set by regulatory authorities, according to some embodiments).
[0114] With conventional mammography systems, large (thick) and dense breasts are difficult, if not impossible, to examine at the same level of confidence as smaller, normal density breast tissue. This seriously limits the value of mammography for women with large and/or dense breasts (30-50% of the population), a population of women who have a six-fold higher incidence of breast cancer. The detection sensitivity falls from 85% to 64% for women with dense breasts and to 45% for women with extremely dense breasts. Additionally, using conventional x-ray imaging systems (i.e., broadband x-ray imaging systems) false positives and unnecessary biopsies occur at unsatisfactory levels. Techniques described herein facilitate monochromatic x-ray imaging capable of providing a better diagnostic solution for women with large and/or dense breasts who have been chronically undiagnosed, over-screened and are most at risk for breast cancer. Though benefits associated with some embodiments have specific advantages for thick and/or dense breasts, it should be appreciated that techniques provided herein for monochromatic x-ray imaging also provide advantages for screening of breasts of any size and density, as well as providing benefits for other clinical diagnostic applications. For example, techniques described herein facilitate reducing patient radiation dose by a factor of 6-26 depending on tissue density for all patients over conventional x-ray imaging systems currently deployed in clinical settings, allowing for annual and repeat exams while significantly reducing the lifetime radiation exposure of the patient. Additionally, according to some embodiments, screening may be performed without painful compression of the breast in certain circumstances. Moreover, the technology described herein facilitates the manufacture of monochromatic x-ray systems that are relatively low cost, keeping within current cost constraints of broadband x-ray systems currently in use for clinical mammography.
[0115] Monochromatic x-ray imaging may be performed with approved contrast agents to further enhance detection of tissue anomalies at a reduced dose. Techniques described herein may be used with three dimensional 3D tomosynthesis at similarly low doses. Monochromatic radiation using techniques described herein may also be used to perform in-situ chemical analysis (e.g., in-situ analysis of the chemical composition of tumors), for example, to improve the chemical analysis techniques described in U.S. patent application Ser. No. 15/825,787, filed Nov. 28, 2017 and titled Methods and Apparatus for Determining Information Regarding Chemical Composition Using X-ray Radiation, which application is incorporated herein in its entirety.
[0116] Conventional monochromatic x-ray sources have previously been developed for purposes other than medical imaging and, as a result, are generally unsuitable for clinical purposes. Specifically, the monochromaticity, intensity, spatial resolution and/or power levels may be insufficient for medical imaging purposes. The inventor has developed techniques for producing monochromatic x-ray radiation suitable for numerous applications, including for clinical purposes such as breast and other tissue imaging, aspects of which are described in further detail below. The inventor recognized that conventional monochromatic x-ray sources emit significant amounts of broadband x-ray radiation in addition to the emitted monochromatic x-ray radiation. As a result, the x-ray radiation emitted from such monochromatic x-ray sources have poor monochromaticity due to the significant amounts of broadband radiation that is also emitted by the source, contaminating the x-ray spectrum.
[0117] The inventor has developed techniques for producing x-ray radiation with high degrees of monochromaticity (e.g., as measured by the ratio of monochromatic x-ray radiation to broadband radiation as discussed in further detail below), both in the on-axis direction and off-axis directions over a relatively large field of view. Techniques described herein enable the ability to increase the power of the broadband x-ray source without significantly increasing broadband x-ray radiation contamination (i.e., without substantially reducing monochromaticity). As a result, higher intensity monochromatic x-ray radiation may be produced using increased power levels while maintaining high degrees of monochromaticity.
[0118] The inventor has further developed geometries for secondary targets (i.e., fluorescent target arranged to emit monochromatic radiation in response to incident broadband x-ray radiation) that significantly increase monochromatic x-ray intensity, allowing for decreased exposure times without degrading image quality or increasing power levels. According to some embodiments, secondary targets are constructed using one or more layers of secondary target material, instead of using solid secondary targets as is conventionally done.
[0119] According to some embodiments, a monochromatic x-ray device is provided that is capable of producing monochromatic x-ray radiation having characteristics (e.g., monochromaticity, intensity, etc.) that enable exposure times of less than 20 seconds, according to some embodiments, exposure times of less than 10 seconds and, according to some embodiments, exposure times of less than? seconds for mammography.
[0120] According to some embodiments, a monochromatic x-ray device is provided that emits monochromatic x-rays having a high degree of monochromaticity (e.g., at 90% purity or better) over a field of view sufficient to image a target organ (e.g., a breast) in a single exposure to produce an image at a spatial resolution suitable for diagnostics (e.g., a spatial resolution of a 100 microns or better).
[0121] Following below are more detailed descriptions of various concepts related to, and embodiments of, monochromatic x-ray systems and techniques regarding same. It should be appreciated that the embodiments described herein may be implemented in any of numerous ways. Examples of specific implementations are provided below for illustrative purposes only. It should be appreciated that the embodiments and the features/capabilities provided may be used individually, all together, or in any combination of two or more, as aspects of the technology described herein are not limited in this respect.
[0122] FIG. 9 illustrates a two dimensional (2D) schematic cut of a conventional x-ray apparatus for generating monochromatic x-rays via x-ray fluoresence. The x-ray apparatus illustrated in FIG. 9 is similar in geometry to the x-ray apparatus illustrated and described in U.S. Pat. No. 4,903,287, titled Radiation Source for Generating Essentially Monochromatic X-rays, as well as the monochromatic x-ray source illustrated and described in Marfeld, et al., Proc. SPIE Vol. 4502, p. 117-125, Advances in Laboratory-based X-ray Sources and Optics II, Ali M. Khounsayr; Carolyn A. MacDonald; Eds. Referring to FIG. 9, x-ray apparatus 900 comprises a vacuum tube 950 that contains a toroidal filament 905 that operates as a cathode and primary target 910 that operates as an anode of the circuit for generating broadband x-ray radiation. Vacuum tube 950 includes a vacuum sealed enclosure formed generally by housing 955, front portion 965 (e.g., a copper faceplate) and a window 930 (e.g., a beryllium window).
[0123] In operation, electrons (e.g., exemplary electrons 907) from filament 905 (cathode) are accelerated toward primary target 910 (anode) due to the electric field established by a high voltage bias between the cathode and the anode. As the electrons are decelerated by the primary target 910, broadband x-ray radiation 915 (i.e., Bremsstrahlung radiation as shown in FIG. 3) is produced. Characteristic emission lines unique to the primary target material may also be produced by the electron bombardment of the anode material provided the voltage is large enough to produce photoelectrons. Thus, broadband x-ray radiation (or alternatively broad spectrum radiation) refers to Bremsstrahlung radiation with or without characteristic emission lines of the primary target. The broadband radiation 915 emitted from primary target 910 is transmitted through window 930 of the vacuum enclosure to irradiate secondary target 920. Window 930 provides a transmissive portion of the vacuum enclosure made of a material (e.g., beryllium) that generally transmits broadband x-ray radiation generated by primary target 910 and blocks electrons from impinging on the secondary target 920 (e.g., electrons that scatter off of the primary target) to prevent unwanted Bremststralung radiation from being produced. Window 930 may be cup-shaped to accommodate secondary target 920 outside the vacuum enclosure, allowing the secondary target to be removed and replaced without breaking the vacuum seal of x-ray tube 950.
[0124] In response to incident broadband x-ray radiation from primary target 910, secondary target 920 generates, via fluorescence, monochromatic x-ray radiation 925 characteristic of the element(s) in the second target. Secondary target 920 is conical in shape and made from a material selected so as to produce fluorescent monochromatic x-ray radiation at a desired energy, as discuss in further detail below. Broadband x-ray radiation 915 and monochromatic x-ray radiation 925 are illustrated schematically in FIG. 9 to illustrate the general principle of using a primary target and a secondary target to generate monochromatic x-ray radiation via fluorescence. It should be appreciated that broadband and monochromatic x-ray radiation will be emitted in the 4 directions by the primary and secondary targets, respectively. Accordingly, x-ray radiation will be emitted from x-ray tube 950 at different angles relative to axis 955 corresponding to the longitudinal axis through the center of the aperture of x-ray tube 950.
[0125] As discussed above, the inventor has recognized that conventional x-ray apparatus for generating monochromatic x-ray radiation (also referred to herein as monochromatic x-ray sources) emit significant amounts of broadband x-ray radiation. That is, though conventional monochromatic sources report the ability to produce monochromatic x-ray radiation, in practice, the monochromaticity of the x-ray radiation emitted by these conventional apparatus is poor (i.e., conventional monochromatic sources exhibit low degrees of monochromaticity. For example, the conventional monochromatic source described in Marfeld, using a source operated at 165 kV with a secondary target of tungsten (W), emits monochromatic x-ray radiation that is approximately 50% pure (i.e., the x-ray emission is approximately 50% broadband x-ray radiation). As another example, a conventional monochromatic x-ray source of the general geometry illustrated in FIG. 9, operating with a cathode at a negative voltage of-50 kV, a primary target made of gold (Au; Z=79) at ground potential, and a secondary target made of tin (Sn; Z=50), emits the x-ray spectra illustrated in FIG. 10A (on-axis) and FIG. 10B (off-axis). As discussed above, x-ray radiation will be emitted from the x-ray tube at different angles relative to the longitudinal axis of the x-ray tube (axis 955 illustrated in FIG. 9).
[0126] Because the on-axis spectrum and the off-axis spectrum play a role in the efficacy of a monochromatic source, both on-axis and off-axis x-ray spectra are shown. In particular, variation in the monochromaticity of x-ray radiation as a function of the viewing angle results in non-uniformity in the resulting images. In addition, for medical imaging applications, decreases in monochromaticity (i.e., increases in the relative amount of broadband x-ray radiation) of the x-ray spectra at off-axis angles increases the dose delivered to the patient. Thus, the degree of monochromaticity of both on-axis and off-axis spectra may be an important property of the x-ray emission of an x-ray apparatus. In FIG. 10A, on-axis refers to a narrow range of angles about the axis of the x-ray tube (less than approximately 0.5 degrees), and off-axis refers to approximately 5 degrees off the axis of the x-ray tube. As shown in FIGS. 10A and 10B, the x-ray spectrum emitted from the conventional monochromatic x-ray source is not in fact monochromatic and is contaminated with significant amounts of broadband x-ray radiation.
[0127] In particular, in addition to the characteristic emission lines of the secondary target (i.e., the monochromatic x-rays emitted via K-shell fluorescence from the tin (Sn) secondary target resulting from transitions from the L and M-shells, labeled as Sn K.sub. and Sn K.sub. in FIGS. 10A and 10B, respectively), x-ray spectra 1000a and 1000b shown in FIGS. 10A and 10B also include significant amounts of broadband x-ray radiation. Specifically, x-ray spectra 1000a and 1000b include significant peaks at the characteristic emission lines of the primary target (i.e., x-ray radiation at the energies corresponding to K-shell emissions of the gold primary target, labeled as Au K and Au K in FIGS. 10A and 10B), as well as significant amounts of Bremsstrahlung background. As indicated by arrows 1003 in FIGS. 10A and 10B, the Sn K.sub. peak is only (approximately) 8.7 times greater than the Bremsstrahlung background in the on-axis direction and approximately 7 times greater than the Bremsstrahlung background in the off-axis direction. Thus, it is clear from inspection alone that this conventional monochromatic x-ray source emits x-ray radiation exhibiting strikingly poor monochromaticity, both on and off-axis, as quantified below.
[0128] Monochromaticity may be computed based on the ratio of the integrated energy in the characteristic fluorescent emission lines of the secondary target to the total integrated energy of the broadband x-ray radiation. For example, the integrated energy of the low energy broadband x-ray radiation (e.g., the integrated energy of the x-ray spectrum below the Sn K.sub. peak indicated generally by arrows 1001 in FIGS. 10A and 10B), referred to herein as P.sub.low, and the integrated energy of the high energy broadband x-ray radiation (e.g., the integrated energy of the x-ray spectrum above the Sn K.sub. peak indicated generally by arrows 1002 in FIGS. 10A and 10B), referred to herein as P.sub.high, may be computed. The ratio of the integrated energy of the characteristic K-shell emission lines (referred to herein as P.sub.k, which corresponds to the integrated energy in the Sn K.sub. and the Sn K.sub. emissions in FIGS. 10A and 10B) to P.sub.low and P.sub.high provides a measure of the amount of broadband x-ray radiation relative to the amount of monochromatic x-ray radiation emitted by the x-ray source. In the example of FIG. 10A, the ratio P.sub.k/P.sub.low is 0.69 and the ratio P.sub.k/P.sub.high is 1.7. In the example of FIG. 10B, the ratio P.sub.k/P.sub.low is 0.9 and the ratio P.sub.k/P.sub.high is 2.4. Increasing the ratios P.sub.low and P.sub.high increases the degree to which the spectral output of the source is monochromatic. As used herein, the monochromaticity, M, of an x-ray spectrum is computed as M=1/(1+1/a+1/b), where a=P.sub.k/P.sub.low, b=P.sub.k/P.sub.high. For the on-axis x-ray spectrum in FIG. 10A produced by the conventional x-ray apparatus, M=0.33, and for the off-axis x-ray spectrum in FIG. 10B produced by the conventional x-ray apparatus, M=0.4. As such, the majority of the energy of the x-ray spectrum is broadband x-ray radiation and not monochromatic x-ray radiation.
[0129] The inventor has developed techniques that facilitate generating an x-ray radiation having significantly higher monochromaticity, thus improving characteristics of the x-ray emission from an x-ray device and facilitating improved x-ray imaging. FIG. 11A illustrates an x-ray device 1100 incorporating techniques developed by the inventor to improve properties of the x-ray radiation emitted from the device, and FIG. 11B illustrates a zoomed in view of components of the x-ray device 1100, in accordance with some embodiments. X-ray device 1100 comprises a vacuum tube 1150 providing a vacuum sealed enclosure for electron optics 1105 and primary target 1110 of the x-ray device. The vacuum sealed enclosure is formed substantially by a housing 1160 (which includes a front portion 1165) and an interface or window portion 1130. Faceplate 1175 may be provided to form an outside surface of front portion 1165. Faceplate 1175 may be comprised of material that is generally opaque to broadband x-ray radiation, for example, a high Z material such as lead, tungsten, thick stainless steel, tantalum, rhenium, etc. that prevents at least some broadband x-ray radiation from being emitted from x-ray device 1100.
[0130] Interface portion 1130 may be comprised of a generally x-ray transmissive material (e.g., beryllium) to allow broadband x-ray radiation from primary target 1110 to pass outside the vacuum enclosure to irradiate secondary target 1120. In this manner, interface portion 1130 provides a window between the inside and outside the vacuum enclosure through which broadband x-ray radiation may be transmitted and, as result, is also referred to herein as the window or window portion 1130. Window portion 1130 may comprise an inner surface facing the inside of the vacuum enclosure and an outer surface facing the outside of the vacuum enclosure of vacuum tube 1150 (e.g., inner surface 1232 and outer surface 1234 illustrated in FIG. 12). Window portion 1130 may be shaped to form a receptacle (see receptacle 1235 labeled in FIG. 12) configured to hold secondary target carrier 1140 so that the secondary target (e.g., secondary target 1120) is positioned outside the vacuum enclosure at a location where at least some broadband x-ray radiation emitted from primary target 1110 will impinge on the secondary target. According to some embodiments, carrier 1140 is removable. By utilizing a removable carrier 1140, different secondary targets can be used with x-ray system 1100 without needing to break the vacuum seal, as discussed in further detail below. However, according to some embodiments, carrier 1140 is not removable.
[0131] The inventor recognized that providing a hybrid interface portion comprising a transmissive portion and a blocking portion facilitates further reducing the amount of broadband x-ray radiation emitted from the x-ray device. For example, FIG. 11C illustrates an interface portion 1130 comprising a transmissive portion 1130a (e.g., a beryllium portion) and a blocking portion 1130b (e.g., a tungsten portion), in accordance with some embodiments. Thus, according to some embodiments, interface portion 1130 may comprise a first material below the dashed line in FIG. 11C and comprise a second material different from the first material above the dashed line. Transmissive portion 1130a and blocking portion 1130b may comprise any respective material suitable for performing intended transmission and absorption function sufficiently, as the aspect are not limited for use with any particular materials.
[0132] According to some embodiments, the location of the interface between the transmissive portion and the blocking portion (e.g., the location of the dashed line in FIG. 11C) approximately corresponds to the location of the interface between the transmissive portion and the blocking portion of the carrier when the carrier is inserted into the receptacle formed by the interface portion. According to some embodiments, the location of the interface between the transmissive portion and the blocking portion (e.g., the location of the dashed line in FIG. 11C) does not correspond to the location of the interface between the transmissive portion and the blocking portion of the carrier when the carrier is inserted into the receptacle formed by the interface portion. A hybrid interface component is also illustrated in FIG. 28A, discussed in further detail below.
[0133] In the embodiment illustrated in FIGS. 11A and 11B, secondary target 1120 has a conical geometry and is made of a material that fluoresces x-rays at desired energies in response to incident broadband x-ray radiation. Secondary target may be made of any suitable material, examples of which include, but are not limited to tin (Sn), silver (Ag), molybdenum (Mo), palladium (Pd), or any other suitable material or combination of materials. FIG. 19 illustrates the x-ray spectra resulting from irradiating secondary target cones of the four exemplary materials listed above. Secondary target 1120 provides a small compact region from which monochromatic x-ray radiation can be emitted via fluorescent to provide good spatial resolution, as discussed in further detail below.
[0134] The inventor has appreciated that removable carrier 1140 can be designed to improve characteristics of the x-ray radiation emitted from vacuum tube 1150 (e.g., to improve the monochromaticity of the x-ray radiation emission). Techniques that improve the monochromaticity also facilitate the ability to generate higher intensity monochromatic x-ray radiation, as discussed in further detail below. In the embodiment illustrated in FIGS. 11A and 11B, removable carrier 1140 comprises a transmissive portion 1142 that includes material that is generally transmissive to x-ray radiation so that at least some broadband x-ray radiation emitted by primary target 1110 that passes through window portion 1130 also passes through transmissive portion 1142 to irradiate secondary target 1120. Transmissive portion 1142 may include a cylindrical portion 1142a configured to accommodate secondary target 1120 and may be configured to allow the secondary target to be removed and replaced so that secondary targets of different materials can be used to generate monochromatic x-rays at the different characteristic energies of the respective material, though the aspects are not limited for use with a carrier that allows secondary targets to be interchanged (i.e., removed and replaced). Exemplary materials suitable for transmissive portion 1142 include, but are not limited to, aluminum, carbon, carbon fiber, boron, boron nitride, beryllium oxide, silicon, silicon nitride, etc.
[0135] Carrier 1140 further comprises a blocking portion 1144 that includes material that is generally opaque to x-ray radiation (i.e., material that substantially absorbs incident x-ray radiation). Blocking portion 1144 is configured to absorb at least some of the broadband x-ray radiation that passes through window 1130 that is not converted by and/or is not incident on the secondary target and/or is configured to absorb at least some of the broadband x-ray radiation that might otherwise escape the vacuum enclosure. In conventional x-rays sources (e.g., conventional x-ray apparatus 900 illustrated in FIG. 9), significant amounts of broadband x-ray radiation is allowed to be emitted from the apparatus, corrupting the fluorescent x-ray radiation emitted by the secondary target and substantially reducing the monochromaticity of the emitted x-ray radiation. In the embodiments illustrated in FIGS. 11A, 11B, 12, 13A-C and 17A-C, the transmissive portion and the blocking portion form a housing configured to accommodate the secondary target.
[0136] According to some embodiments, blocking portion 1144 includes a cylindrical portion 1144a and an annular portion 1144b. Cylindrical portion 1144a allows x-ray radiation fluoresced by the secondary target 1120 in response to incident broadband x-ray radiation from primary target 1110 to be transmitted, while absorbing at least some broadband x-ray radiation as discussed above. Annular portion 1144b provides a portion providing increased surface area to absorb additional broadband x-ray radiation that would otherwise be emitted by the x-ray device 1100. In the embodiment illustrated in FIGS. 11A and 11B, annular portion 1144b is configured to fit snugly within a recess in the front portion of the x-ray tube to generally maximize the amount of broadband x-ray radiation that is absorbed to the extent possible. Annular portion 1144b includes an aperture portion 1144c that corresponds to the aperture through cylindrical portions 1144b and 1142a to allow monochromatic x-ray radiation fluoresced from secondary target 1120 to be emitted from x-ray device 1100, as also shown in FIGS. 13B and 17B discussed below. Exemplary materials suitable for blocking portion 1144 include, but are not limited to, lead, tungsten, tantalum, rhenium, platinum, gold, etc.
[0137] In the embodiment illustrated FIGS. 11A and 11B, carrier 1140 is configured so that a portion of the secondary target is contained within blocking portion 1144. Specifically, as illustrated in the embodiment shown in FIGS. 11A and 11B, the tip of conical secondary target 1120 extends into cylindrical portion 1144b when the secondary target is inserted into transmissive portion 1142 of carrier 1140. The inventor has appreciated that having a portion of the secondary target contained within blocking portion 1144 improves characteristics of the monochromatic x-ray radiation emitted from the x-ray device, as discussed in further below. However, according to some embodiments, a secondary target carrier may be configured so that no portion of the secondary target is contained with the blocking portion of the carrier, examples of which are illustrated FIGS. 13A-C discussed in further detail below. Both configurations of carrier 1140 (e.g., with and without blocking overlap of the secondary target carrier) provide significant improvements to characteristics of the emitted x-ray radiation (e.g., improved monochromaticity), as discussed in further detail below.
[0138] As illustrated in FIG. 12, carrier 1240 (which may be similar or the same as carrier 1140 illustrated in FIGS. 11A and 11B) is configured to be removeable. For example, carrier 1240 may be removeably inserted into receptacle 1235 formed by interface component 1230 (e.g., an interface comprising a transmissive window), for example, by inserting and removing the carrier, respectively, in the directions generally indicated by arrow 1205. That is, according to some embodiments, carrier 1240 is configured as a separate component that can be inserted into and removed from the x-ray device (e.g., by inserting removeable carrier 1240 into and/or removing the carrier from receptacle 1235).
[0139] As shown in FIG. 12, carrier 1240 has a proximal end 1245 configured to be inserted into the x-ray device and a distal end 1247 from which monochromatic x-ray radiation is emitted via aperture 1244d through the center of carrier 1240. In the embodiment illustrated in FIG. 12, cylindrical blocking portion 1244a is positioned adjacent to and distally from cylindrical transmissive portion 1242a. Annular blocking portion 1244b is positioned adjacent to and distally from block portion 1244a. As shown, annular blocking portion 1244b has a diameter D that is larger than a diameter d of the cylindrical blocking portion 1244a (and cylindrical transmissive portion 1242a for embodiments in which the two cylindrical portions have approximately the same diameter). The distance from the extremes of the proximal end and the distal end is labeled as height H in FIG. 12. The dimensions of carrier 1240 may depend on the dimensions of the secondary target that the carrier is configured to accommodate. For example, for an exemplary carrier 1240 configured to accommodate a secondary target having a 4 mm base, diameter d may be approximately 4-5 mm, diameter D may be approximately 13-16 mm, and height H may be approximately 18-22 mm. As another example, for an exemplary carrier 1240 configured to accommodate a secondary target having a 8 mm base, diameter d may be approximately 8-9 mm, diameter D may be approximately 18-22 mm, and height H may be approximately 28-32 mm. It should be appreciated that the dimensions for the carrier and the secondary target provided are merely exemplary, and can be any suitable value as the aspect are not limited for use with any particular dimension or set of dimensions.
[0140] According to some embodiments, carrier 1240 may be configured to screw into receptacle 1235, for example, by providing threads on carrier 1240 capable of being hand screwed into cooperating threads within receptacle 1235. Alternatively, a releasable mechanical catch may be provided to allow the carrier 1240 to be held in place and allows the carrier 1240 to be removed by applying force outward from the receptacle. As another alternative, the closeness of the fit of carrier 1240 and receptacle 1235 may be sufficient to hold the carrier in place during operation. For example, friction between the sides of carrier 1240 and the walls of receptacle 1235 may be sufficient to hold carrier 1240 in position so that no additional fastening mechanism is needed. It should be appreciated that any means sufficient to hold carrier 1240 in position when the carrier is inserted into the receptacle may be used, as the aspects are not limited in this respect.
[0141] As discussed above, the inventor has developed a number of carrier configuration that facilitate improved monochromatic x-ray radiation emission. FIGS. 13A and 13B illustrate a three-dimensional and a two-dimensional view of a carrier 1340, in accordance with some embodiments. The three-dimensional view in FIG. 13A illustrates carrier 1340 separated into exemplary constituent parts. In particular, FIG. 13A illustrates a transmissive portion 1342 separated from a blocking portion 1344. As discussed above, transmissive portion 1342 may include material that generally transmits broadband x-ray radiation at least at the relevant energies of interest (i.e., material that allows broadband x-ray radiation to pass through the material without substantial absorption at least at the relevant energies of interest, such as aluminum, carbon, carbon fiber, boron, boron nitride, beryllium oxide, silicon, silicon nitride, etc. Blocking portion 1344, on the other hand, may include material that is generally opaque to broadband x-ray radiation at least at the relevant energies of interest (i.e., material that substantially absorbs broadband x-ray radiation at least at the relevant energies of interest, such as lead, tungsten, tantalum, rhenium, platinum, gold, etc.
[0142] In this way, at least some broadband x-ray radiation emitted by the primary target is allowed to pass through transmissive portion 1342 to irradiate the secondary target, while at least some broadband x-ray radiation emitted from the primary target (and/or emitted from or scattered by other surfaces of the x-ray tube) is absorbed by blocking portion 1344 to prevent unwanted broadband x-ray radiation from being emitted from the x-ray device. As a result, carrier 1340 facilitates providing monochromatic x-ray radiation with reduced contamination by broadband x-ray radiation, significantly improving monochromaticity of the x-ray emission of the x-ray device. In the embodiments illustrated in FIGS. 13A-C, blocking portion 1344 includes a cylindrical portion 1344a and annular portion 1344b having a diameter greater than cylindrical portion 1344a to absorb broadband x-ray radiation emitted over a wider range of angles and/or originating from a wider range of locations to improve the monochromaticity of the x-ray radiation emission of the x-ray device.
[0143] According to some embodiments, transmissive portion 1342 and blocking portion 1344 may be configured to couple together or mate using any of a variety of techniques. For example, the transmissive portion 1342, illustrated in the embodiment of FIG. 13A as a cylindrical segment, may include a mating portion 1343a at one end of the cylindrical segment configured to mate with mating portion 1342b at a corresponding end of cylindrical portion 1344a of blocking portion 1344. Mating portion 1343a and 1343b may be sized appropriately and, for example, provided with threads to allow the transmissive portion 1342 and the blocking portion 1344 to be mated by screwing the two portion together. Alternatively, mating portion 1343a and 1343b may be sized so that mating portion 1343a slides over mating portion 1343b, or vice versa, to couple the two portions together. It should be appreciated that any mechanism may be used to allow transmissive portion 1342 and blocking portion 1344 to be separated and coupled together. According to some embodiments, transmissive portion 1342 and blocking portion 1344 are not separable. For example, according to some embodiments, carrier 1340 may be manufactured as a single component having transmissive portion 1342 fixedly coupled to blocking portion 1344 so that the portions are not generally separable from one another as a general matter of course.
[0144] Transmissive portion 1342 may also include portion 1325 configured to accommodate secondary target 1320. For example, one end of transmissive portion 1342 may be open and sized appropriately so that secondary target 1320 can be positioned within transmissive portion 1342 so that, when carrier 1340 is coupled to the x-ray device (e.g., inserted into a receptacle formed by an interface portion of the vacuum tube, such as a transmissive window or the like), secondary target 1320 is positioned so that at least some broadband x-ray radiation emitted from the primary target irradiates secondary target 1320 to cause secondary target to fluoresce monochromatic x-rays at the characteristic energies of the selected material. In this way, different secondary targets 1320 can be positioned within and/or held by carrier 1340 so that the energy of the monochromatic x-ray radiation is selectable. According to some embodiments, secondary target 1320 may include a portion 1322 that facilitates mating or otherwise coupling secondary target 1320 to the carrier 1340. For example, portions 1322 and 1325 may be provide with cooperating threads that allow the secondary target to be screwed into place within the transmissive portion 1342 of carrier 1340. Alternatively, portions 1322 and 1325 may be sized so that the secondary target fits snuggly within transmissive portion and is held by the closeness of the fit (e.g., by the friction between the two components) and/or portion 1322 and/or portion 1325 may include a mechanical feature that allows the secondary target to held into place. According to some embodiments, a separate cap piece may be included to fit over transmissive portion 1342 after the secondary target has been inserted into the carrier and/or any other suitable technique may be used to allow secondary target 1320 to be inserted within and sufficiently held by carrier 1340, as the aspects are not limited in this respect.
[0145] In the embodiment illustrated in FIG. 13B, secondary target 1320 is contained within transmissive portion 1342, without overlap with blocking portion 1344. That is, the furthest extent of secondary target 1320 (e.g., the tip of the conical target in the embodiment illustrated in FIG. 13B) does not extend into cylindrical portion 1344a of the blocking portion (or any other part of the blocking portion). By containing secondary target 1320 exclusively within the transmissive portion of the carrier, the volume of secondary target 1320 exposed to broadband x-ray radiation and thus capable of fluorescing monochromatic x-ray radiation may be generally maximized, providing the opportunity to generally optimize the intensity of the monochromatic x-ray radiation produced for a given secondary target and a given set of operating parameters of the x-ray device (e.g., power levels of the x-ray tube, etc.). That is, by increasing the exposed volume of the secondary target, increased monochromatic x-ray intensity may be achieved.
[0146] The front view of annular portion 1344b of blocking portion 1334 illustrated in FIG. 13B illustrates that annular portion 1344b includes aperture 1344c corresponding to the aperture of cylindrical portion 1344a (and cylindrical portion 1342) that allows monochromatic x-rays fluoresced from secondary target 1320 to be emitted from the x-ray device. Because blocking portion 1344 is made from a generally opaque material, blocking portion 1344 will also absorb some monochromatic x-rays fluoresced from the secondary target emitted at off-axis angles greater than some threshold angle, which threshold angle depends on where in the volume of the secondary target the monochromatic x-rays originated. As such, blocking portion 1344 also operates as a collimator to limit the monochromatic x-rays emitted to a range of angles relative to the axis of the x-ray tube, which in the embodiments in FIGS. 13A-C, corresponds to the longitudinal axis through the center of carrier 1340.
[0147] FIG. 13C illustrates a schematic of carrier 1340 positioned within an x-ray device (e.g., inserted into a receptacle formed by an interface portion of the vacuum tube, such as exemplary window portions 1130 and 1230 illustrated in FIGS. 11A, 11B and 12). Portions 1365 correspond to the front portion of the vacuum tube, conventionally constructed of a material such as copper. In addition, a cover or faceplate 1375 made of a generally opaque material (e.g., lead, tungsten, tantalum, rhenium, platinum, gold, etc.) is provided having an aperture corresponding to the aperture of carrier 1340. Faceplate 1375 may be optionally included to provide further absorption of broadband x-ray to prevent spurious broadband x-ray radiation from contaminating the x-ray radiation emitted from the x-ray device.
[0148] According to some embodiments, exemplary carrier 1340 may be used to improve monochromatic x-ray emission characteristics. For example, FIGS. 14A and 14B illustrate the on-axis x-ray spectrum 1400a and off-axis x-ray spectrum 1400b resulting from the use of carrier 1340 illustrated in FIGS. 13A, 13B and/or 13C. As shown, the resulting x-ray spectrum is significantly improved relative to the on-axis and off-axis x-ray spectra shown in FIGS. 10A and 10B that was produced by a conventional x-ray apparatus configured to produce monochromatic x-ray radiation (e.g., conventional x-ray apparatus 900 illustrated in FIG. 9). As indicated by arrow 1403 in FIG. 14A, the on-axis Sn K.sub. peak is approximately 145 times greater than the Bremsstrahlung background, up from approximately 8.7 in the on-axis spectrum illustrated in FIG. 10A. The off-axis Sn K.sub. peak is approximately 36 times greater than the Bremsstrahlung background as indicated by arrow 1403 in FIG. 14B, up from approximately 7.0 in the off-axis spectrum illustrated in FIG. 14B. In addition, the ratios of P.sub.k (the integrated energy of the characteristic K-shell emission lines, labeled as Sn K.sub. and Sn K.sub. in FIGS. 14A and 14B) to P.sub.low (the integrated energy of the low energy x-ray spectrum below the Sn K.sub. peak, indicated generally by arrows 1401 in FIGS. 14A and 14B) and P.sub.high (the integrated energy of the high energy spectrum above the Sn K.sub. peak, indicated generally by arrows 1402) are 21 and 62, respectively, for the on-axis spectrum illustrated in FIG. 14A, up from 0.69 and 1.7 for the on-axis spectrum of FIG. 10A. The ratios P.sub.k/P.sub.low and P.sub.k/P.sub.high are 12.9 and 22, respectively, for the off-axis spectrum illustrated in FIG. 14B, up from 0.9 and 2.4 for the off-axis spectrum of FIG. 10B. These increased ratios translate to an on-axis monochromaticity of 0.94 (M=. 94) and an off-axis monochromaticity of 0.89 (M=. 89), up from an on-axis monochromaticity of 0.33 and an off-axis monochromaticity of 0.4 for the x-ray spectrum of FIGS. 10A and 10B, respectively.
[0149] This significant improvement in monochromaticity facilitates acquiring x-ray images that are more uniform, have better spatial resolution and that deliver significantly less x-ray radiation dose to the patient in medical imaging applications. For example, in the case of mammography, the x-ray radiation spectrum illustrated in FIGS. 10A and 10B would deliver four times the mean glandular dose to normal thickness and density breast tissue than would be delivered by the x-ray radiation spectrum illustrated in FIGS. 14A and 14B. FIG. 14C illustrates the field of view of the conventional x-ray source used to generate the x-ray spectrum illustrated in FIGS. 10A and 10B along with the field of view of the x-ray device used to generate the x-ray spectrum illustrated in FIGS. 14A and 14B. The full width at half maximum (FWHM) of the conventional x-ray apparatus is approximately 30 degrees, while the FWHM of the improved x-ray device is approximately 15 degrees. Accordingly, although the field of view is reduced via exemplary carrier 1340, the resulting field of view is more than sufficient to image an organ such as the breast in a single exposure at compact source detector distances (e.g., approximately 760 mm), but with increased uniformity and spatial resolution and decreased radiation dose, allowing for significantly improved and safer x-ray imaging. FIG. 15 illustrates the integrated power ratios for the low and high energy x-ray radiation (Pk/P.sub.low and Pk/P.sub.High) as a function of the viewing angle and FIG. 16 illustrates the monochromaticity of the x-ray radiation for the conventional x-ray apparatus (1560a, 1560b and 1660) and the improved x-ray apparatus using exemplary carrier 1340 (1570a, 1570b and 1670). As shown by plots 1570a, 1570b and 1670, monochromaticity decreases as a function of viewing angle. Using carrier 1340, monochromatic x-ray radiation is emitted having a monochromaticity of at least 0.7 across a 15 degree field of view and a monochromaticity of at least 0.8 across a 10 degree field of view about the longitudinal axis. As shown by plots 1560a, 1560b and 1660, monochromaticity of the conventional x-ray apparatus is extremely poor across all viewing angles (i.e., less than 0.4 across the entire field of view).
[0150] The inventor has appreciated that further improvements to aspects of the monochromaticity of x-ray radiation emitted from an x-ray tube may be improved by modifying the geometry of the secondary target carrier. According to some embodiments, monochromaticity may be dramatically improved, in particular, for off-axis x-ray radiation. For example, the inventor recognized that by modifying the carrier so that a portion of the secondary target is within a blocking portion of the carrier, the monochromaticity of x-ray radiation emitted by an x-ray device may be improved, particularly with respect to off-axis x-ray radiation. FIGS. 17A and 17B illustrate a three-dimensional and a two-dimensional view of a carrier 1740, in accordance with some embodiments. Exemplary carrier 1740 may include similar parts to carrier 1340, including a transmissive portion 1742 to accommodate secondary target 1720, and a blocking portion 1744 (which may include a cylindrical portion 1744a and annular portion 1744b with an aperture 1744c through the center), as shown in FIG. 17A.
[0151] However, in the embodiment illustrated in FIGS. 17A-C, carrier 1740 is configured so that, when secondary target 1720 is positioned within transmissive portion 1742, a portion of secondary target 1720 extends into blocking portion 1744. In particular, blocking portion includes an overlap portion 1744d that overlaps part of secondary target 1720 so that at least some of the secondary target is contained within blocking portion 1744. According to some embodiments, overlap portion 1744d extends over between approximately 0.5 and 5 mm of the secondary target. According to some embodiments, overlap portion 1744d extends over between approximately 1 and 3 mm of the secondary target. According to some embodiments, overlap portion 1744d extends over approximately 2 mm of the secondary target. According to some embodiments, overlap portion 1744d extends over less than 0.5 mm, and in some embodiments, overlap portion 1744d extends over greater than 5 mm. The amount of overlap will depend in part on the size and geometry of the secondary target, the carrier and the x-ray device. FIG. 17C illustrates carrier 1740 positioned within an x-ray device (e.g., inserted in a receptacle formed at the interface of the vacuum tube), with a faceplate 1775 provided over front portion 1765 of a vacuum tube (e.g., vacuum tube 1150 illustrated in FIG. 11A).
[0152] According to some embodiments, exemplary carrier 1740 may be used to further improve monochromatic x-ray emission characteristics. For example, FIGS. 18A and 18B illustrate the on-axis x-ray spectrum 1800a and off-axis x-ray spectrum 1800b resulting from the use of carrier 1740 illustrated in FIGS. 17A-C. As shown, the resulting x-ray spectrum are significantly improved relative to the on-axis and off-axis x-ray spectrum produced the conventional x-ray apparatus shown in FIGS. 10A and 10B, as well as exhibiting improved characteristics relative to the x-ray spectra produced using exemplary carrier 1340 illustrated in FIGS. 13A-C. As indicated by arrow 1803 in FIG. 18A, the on-axis Sn K.sub. peak is 160 times greater than the Bremsstrahlung background, compared to 145 for the on-axis spectrum in FIG. 14A and 8.7 for the on-axis spectrum illustrated in FIG. 10A. As indicated by arrow 1803 in FIG. 18B, the off-axis Sn K.sub. peak is 84 times greater than the Bremsstrahlung background, compared to 36 for the off-axis spectrum in FIG. 14B and 7.0 for the off-axis spectrum illustrated in FIG. 10B.
[0153] The ratios of P.sub.k (the integrated energy of the characteristic K-shell emission lines, labeled as Sn K.sub. and Sn K.sub. in FIGS. 18A and 18B) to P.sub.low (the integrated energy of the low energy x-ray spectrum below the Sn K.sub. peak, indicated generally by arrows 1801 in FIGS. 18A and 18B) and P.sub.high (the integrated energy of the high energy spectrum above the Sn K.sub. peak, indicated generally by arrows 1802) are 31 and 68, respectively, for the on-axis spectrum illustrated in FIG. 18A, compared to 21 and 62 for the on-axis spectrum of FIG. 14A and 0.69 and 1.7 for the on-axis spectrum of FIG. 10A. The ratios P.sub.k/P.sub.low and P.sub.k/P.sub.high are 29 and 68, respectively, for the off-axis spectrum of FIG. 18B, compared to 12.9 and 22, respectively, for the off-axis spectrum illustrated in FIG. 14B and 0.9 and 2.4 for the off-axis spectrum of FIG. 10B. These increased ratios translate to an on-axis monochromaticity of 0.96 (M=0.96) and an off-axis monochromaticity of 0.95 (M=0.95), compared to an on-axis monochromaticity of 0.94 (M=0.94) for x-ray spectrum of FIG. 14A and an off-axis monochromaticity of 0.89 (M=0.89) for the x-ray spectrum of FIG. 14B, and an on-axis monochromaticity of 0.33 and an off-axis monochromaticity of 0.4 for the x-ray spectra of FIGS. 10A and 10B, respectively.
[0154] Referring again to FIGS. 15 and 16, the stars indicate the on-axis and off-axis low energy ratio (1580a) and high energy ratio (1580b), as well as the on-axis and off-axis monochromaticity (1680), respectively, of the x-ray radiation emitted using exemplary carrier 1640. As shown, the x-ray radiation exhibits essentially the same characteristics on-axis and 5 degrees off-axis. Accordingly, while exemplary carrier 1740 improves both on-axis and off-axis monochromaticity, use of the exemplary carrier illustrate in FIGS. 17A-C exhibits a substantial increase in the off-axis monochromaticity, providing substantial benefits to x-ray imaging using monochromatic x-rays, for example, by improving uniformity, reducing dose and enabling the use of higher x-ray tube voltages to increase the mononchromatic intensity to improve the spatial resolution and ability differentiate small density variations (e.g., small tissue anomalies such as micro-calcifications in breast material), as discussed in further detail below. Using carrier 1740, monochromatic x-ray radiation is emitted having a monochromaticity of at least 0.9 across a 15 degree field of view and a monochromaticity of at least 0.95 across a 10 degree field of view about the longitudinal axis.
[0155] It should be appreciated that the exemplary carrier described herein may be configured to be a removable housing or may be integrated into the x-ray device. For example, one or more aspects of the exemplary carriers described herein may integrated, built-in or otherwise made part an x-ray device, for example, as fixed components, as the aspects are not limited in this respect.
[0156] As is well known, the intensity of monochromatic x-ray emission may be increased by increasing the cathode-anode voltage (e.g., the voltage potential between filament 1106 and primary target 1100 illustrated in FIGS. 11A and 11B) and/or by increasing the filament current which, in turn, increases the emission current of electrons emitted by the filament, the latter technique of which provides limited control as it is highly dependent on the properties of the cathode. The relationship between x-ray radiation intensity, cathode-anode voltage and emission current is shown in FIG. 20, which plots x-ray intensity, produced using a silver (Ag) secondary target and a source-detector distance of 750 mm, against emission current at a number of different cathode-anode voltages using two different secondary target geometries (i.e., an Ag cone having a 4 mm diameter base and an Ag cone having a 8 mm diameter base).
[0157] Conventionally, the cathode-anode voltage was selected to be approximately twice that of the energy of the characteristic emission line of the desired monochromatic x-ray radiation to be fluoresced by the secondary target as a balance between producing sufficient high energy broadband x-ray radiation above the absorption edge capable of inducing x-ray fluorescence in the secondary target to produce adequate monochromatic x-ray intensity, and producing excess high energy broadband x-ray radiation that contaminates the desired monochromatic x-ray radiation. For example, for an Ag secondary target, a cathode-anode potential of 45 kV (e.g., the electron optics would be set at 45 kV) would conventionally be selected to ensure sufficient high energy broadband x-rays are produced above the K-edge of silver (25 keV) as illustrated in FIG. 21 to produce the 22 keV Ag K monochromatic x-ray radiation shown in FIG. 19 (bottom left). Similarly, for a Sn secondary target, a cathode-anode potential of 50 kV would conventionally be selected to ensure sufficient high energy broadband x-rays are produced above the K-edge of tin (29 keV) as illustrated in FIG. 21 to produce the 25 keV Sn K monochromatic x-ray radiation shown in FIG. 19 (bottom right). This factor of two limit on the cathode-anode voltage was conventionally followed to limit the high energy contamination of the monochromatic x-rays emitted from the x-ray apparatus.
[0158] The inventor has recognized that the techniques described herein permit the factor of two limit to be eliminated, allowing high cathode-anode voltages to be used to increase mononchromatic x-ray intensity without significantly increasing broadband x-ray radiation contamination (i.e., without substantial decreases in monochromaticity). In particular, techniques for blocking broadband x-ray radiation, including the exemplary secondary target carriers developed by the inventors can be used to produce high intensity monochromatic radiation while maintaining excellent monochromaticity. For example, FIG. 22 illustrates the on-axis monochromaticity 2200a and the off-axis monochromaticity 2200b for a number of cathode-anode voltages (primary voltage) with a Sn secondary target using exemplary carrier 1740 developed by the inventor. Similarly, FIG. 23 illustrates the on-axis monochromaticity 2300a and the off-axis monochromaticity 2300b for a number of cathode-anode voltages (primary voltage) with an Ag secondary target using exemplary carrier 1740 developed by the inventor. As shown, a high degree of monochromaticity is maintained across the illustrated range of high voltages, varying by only 1.5% over the range illustrated. Thus, higher voltages can be used to increase the monochromatic x-ray intensity (e.g., along the lines shown in FIG. 20) without substantially impacting monochromaticity. For example, monochromatic x-ray radiation of over 90% purity (M>0.9) can be generated using a primary voltage up to and exceeding 100 KeV, significantly increasing the monochromatic x-ray intensity.
[0159] According to some embodiments, a primary voltage (e.g., a cathode-anode voltage potential, such as the voltage potential between filament 1106 and primary target 1110 of x-ray tube 1150 illustrated in FIGS. 11A and 11B) greater than two times the energy of the desired monochromatic x-ray radiation fluoresced from a given target is used to generate monochromatic x-ray radiation. According to some embodiments, a primary voltage greater than or equal to approximately two times and less than or equal to approximately three times the energy of the desired monochromatic x-ray radiation fluoresced from a given target is used to generate monochromatic x-ray radiation. According to some embodiments, a primary voltage greater than or equal to approximately three times and less than or equal to approximately four times the energy of the desired monochromatic x-ray radiation fluoresced from a given target is used to generate monochromatic x-ray radiation. According to some embodiments, a primary voltage greater than or equal to approximately four times and less than or equal to approximately five times the energy of the desired monochromatic x-ray radiation fluoresced from a given target is used to generate monochromatic x-ray radiation. According to some embodiments, a primary voltage greater than or equal to five times greater the energy of the desired monochromatic x-ray radiation fluoresced from a given target is used to generate monochromatic x-ray radiation. In each case, x-ray radiation having monochromaticity of greater than or equal to 0.9, on and off axis across the field of view may be achieved, though it should be appreciated that achieving those levels of monochromaticity is not a requirement.
[0160] The inventor has recognized the geometry of the x-ray tube may contribute to broadband x-ray radiation contamination. The inventor has appreciated that the electron optics of an x-ray tube may be improved to further reduce the amount of broadband x-ray radiation that is generated that could potentially contaminate the monochromatic x-rays emitted from an x-ray device. Referring again to FIGS. 11A and 11B, x-ray device 1100 includes electron optics 1105 configured to generate electrons that impinge on primary target 1110 to produce broadband x-ray radiation. The inventor has developed electron optics geometry configured to reduce and/or eliminate bombardment of surfaces other than the primary target within the vacuum enclosure. This geometry also reduces and/or eliminates parasitic heating of other surfaces that would have to be removed via additional cooling in conventional systems.
[0161] As an example, the geometry of electron optics 1105 is configured to reduce and/or eliminate bombardment of window portion 1130 and/or other surfaces within vacuum tube 1150 to prevent unwanted broadband x-ray radiation from being generated and potentially emitted from the x-ray tube to degrade the monochromaticity of the emitted x-ray radiation spectrum. In the embodiment illustrated in FIGS. 11A and 11B, electron optics 1105 comprises a filament 1106, which may be generally toroidal in shape, and guides 1107, 1108 and/or 1109 positioned on the inside and outside of the toroidal filament 1106. For example, guides 1107, 1108, 1109 may be positioned concentrically with the toroidal filament 1106 (e.g., an inner guide 1107 positioned within the filament torus and an outer guides 1108 and 1109 positioned around the filament torus) to provide walls on either side of filament 1106 to prevent at least some electrons from impinging on surfaces other than primary target 1110, as discussed in further detail below.
[0162] According to some embodiments, electronic optics 105 is configured to operate at a high negative voltage (e.g., 40 kV, 50 kV, 60 kV, 70 KV, 80 kV, 90 kV or more). That is, filament 1106, inner guide 1107 and outer guides 1108, 1109 may all be provided at a high negative potential during operation of the device. As such, in these embodiments, primary target 1110 may be provided at a ground potential so that electrons emitted from filament 1106 are accelerated toward primary target 1110. However, the other components and surfaces of x-ray tube within the vacuum enclosure are typically also at ground potential. As a result, electrons will also accelerate toward and strike other surfaces of x-ray tube 1150, for example, the transmissive interface between the inside and outside of the vacuum enclosure (e.g., window 1130 in FIGS. 11a and 11b). Using conventional electron optics, this bombardment of unintended surfaces produces broadband x-ray radiation that contributes to the unwanted broadband spectrum emitted from the x-ray device and causes undesirable heating of the x-ray tube. The inventor appreciated that this undesirable bombardment of surfaces other than primary target 1110 may be reduced and/or eliminated using inner guide 1107 and outer guides 1108 and/or 1109 that provide a more restricted path for electrons emitted by filament 1106.
[0163] According to some embodiments, guides 1107-1109 are cylindrical in shape and are arranged concentrically to provide a restricted path for electrons emitted by filament 1106 that guides the electrons towards primary target 1110 to prevent at least some unwanted bombardment of other surfaces within the vacuum enclosure (e.g., reducing and/or eliminating electron bombardment of window portion 1130). However, it should be appreciated that the guides used in any given implementation may be of any suitable shape, as the aspects are not limited in this respect. According to some embodiments, guides 1107, 1108 and/or 1109 comprise copper, however, any suitable material that is electrically conducting (and preferably non-magnetic) may be used such as stainless steel, titanium, etc. It should be appreciated that any number of guides may be used. For example, an inner guide may be used in conjunction with a single outer guide (e.g., either guide 1108 or 1109) to provide a pair guides, one on the inner side of the cathode and one on the outer side of the cathode. As another example, a single inner guide may be provided to prevent at least some unwanted electrons from bombarding the interface between the inside and outside of the vacuum tube (e.g., window portion 1130 in FIGS. 11A and 11B), or a single outer guide may be provide to prevent at least some unwanted electrons from bombarding other internal surface of the vacuum tube provides. Additionally, more than three guides may be used to restrict the path of electrons to the primary target to reduce and/or eliminate unwanted bombardment of surfaces within the vacuum enclosure, as the aspects are not limited in this respect.
[0164] FIGS. 24A and 24B illustrate a cross-section of a monochromatic x-ray source 2400 with improved electron optics, in accordance with some embodiments. In the embodiment illustrated, there is a 80 kV potential between the cathode and the anode. Specifically, a tungsten toroidal cathode 2406 is bias at 80 kV and a gold-coated tungsten primary target 2410 is at a ground potential. A copper inner guide 2407 and outer copper guides 2408 and 2409 are also provided at 80 kV to guide electrons emitted from the cathode to prevent at least some electrons from striking surfaces other than primary target 2410 to reduce the amount of spurious broadband x-ray radiation. Monochromatic x-ray source 2400 uses a silver secondary target 2420 and a beryllium interface component 2430. FIG. 24B illustrates the electron trajectories between the toroidal cathode and the primary target when the monochromatic x-ray source 2400 is operated. FIGS. 25 and 26 illustrate the locus of points where the electrons strike primary target 2410, demonstrating that the guides prevent electrons from striking the interface component 2430 in this configuration. FIG. 27 illustrates a monochromatic x-ray source including a hybrid interface component having transmissive portion of beryllium and a blocking portion of tungsten that produces monochromatic x-ray radiation of 97% purity (M=0.97) when combined with other techniques described herein (e.g., using the exemplary carriers described herein). FIG. 28 illustrates an alternative configuration in which the cathode is moved further away from the primary target, resulting in divergent electron trajectories and reduced monochromaticity.
[0165] The monochromatic x-ray sources described herein are capable of providing relatively high intensity monochromatic x-ray radiation having a high degree of monochromaticity, allowing for relatively short exposure times that reduce the radiation dose delivered to a patient undergoing imaging while obtaining images with high signal-to-noise ratio. Provided below are results obtained using techniques described herein in the context of mammography. These results are provided to illustrate the significant improvements that are obtainable using one or more techniques described herein, however, the results are provided as examples as the aspects are not limited for use in mammography, nor are the results obtained requirements on any of the embodiments described herein.
[0166] FIG. 29 illustrates a mammographic phantom (CIRS Model 011a) 2900 used to test aspects of the performance of the monochromatic x-ray device developed by the inventor incorporating techniques described herein. Phantom 2900 includes a number of individual features of varying size and having different absorption properties, as illustrated by the internal view of phantom 2900 illustrated in FIG. 29. FIG. 30 highlights some of the embedded features of phantom 2900, including the linear array of 5 blocks, each 1 cm thick and each having a composition simulating different densities of breast tissue. The left most block simulates 100% glandular breast tissue, the right most, 100% adipose (fat) tissue and the other three have a mix of glandular and adipose with ratios ranging from 70:30 (glandular:adipose) to 50:50 to 30:70. All 5 blocks are embedded in the phantom made from a 50:50 glandular to adipose mix. The total thickness of the phantom is 4.5 cm.
[0167] FIG. 30 also shows a schematic description of the imaging process in one dimension as the x-ray beam enters the phantom, passes through the blocks and the phantom on their way to the imaging detector where the transmitted x-ray intensity, is converted into an integrated value of Gray counts. (The intensity in this case is the sum of the x-ray energies reaching each detector pixel. The electronics in each pixel convert this energy sum into a number between 0 and 7000, where 7000 represents the maximum energy sum allowable before the electronics saturate. The number resulting from this digital conversion is termed a Gray count).
[0168] The data shown by the red horizontal line in a) of FIG. 30 is the x-ray intensity, B, measured through the background 50:50 glandular-adipose mixture. The data shown by the black curve is the x-ray intensity, W, transmitted through the 50:50 mix and the 1 cm blocks. The varying step sizes represent different amounts of x-ray absorption in the blocks due to their different compositions. Plot b) in FIG. 30 defines the signal, S, as W-B and plot c) of FIG. 30 defines the contrast as S/B. The figure of merit that is best used to determine the detectability of an imaging system is the Signal-to-Noise Ratio, SNR. For the discussion here, the SNR is defined as S/noise, where the noise is the standard deviation of the fluctuations in the background intensity shown in plot a) of FIG. 30. Images produced using techniques described herein and may with 22 keV x-rays and 25 keV x-rays and presented herein and compared to the SNR values with those from a commercial broad band x-ray mammography machine.
[0169] Radiation exposure in mammographic examinations is highly regulated by the Mammography Quality Standards Act (MQSA) enacted in 1994 by the U.S. Congress. The MQSA sets a limit of 3 milliGray (mGy) for the mean glandular dose (mgd) in a screening mammogram; a Gray is a joule/kilogram. This 3 mGy limit has important ramifications for the operation of commercial mammography machines, as discussed in further detail below. Breast tissue is composed of glandular and adipose (fatty) tissue. The density of glandular tissue (=1.03 gm/cm.sup.3) is not very different from the density of adipose tissue (=0.93 gm/cm.sup.3) which means that choosing the best monochromatic x-ray energy to optimize the SNR does not depend significantly on the type of breast tissue. Instead, the choice of monochromatic energy for optimal imaging depends primarily on breast thickness. A thin breast will attenuate fewer x-rays than a thick breast, thereby allowing a more significant fraction of the x-rays to reach the detector. This leads to a higher quality image and a higher SNR value. These considerations provide the major rationale for requiring breast compression during mammography examinations with a conventional, commercial mammography machine.
[0170] Imaging experiments were conducted the industry-standard phantom illustrated in FIG. 29, which has a thickness of 4.5 cm and is representative of a typical breast under compression. Phantom 2900 has a uniform distribution of glandular-to-adipose tissue mixture of 50:50. The SNR and mean glandular dose are discussed in detail below for CIRS phantom images obtained with monochromatic energies of 22 keV and 25 keV. Experiments were also conducted with a double phantom, as illustrated in FIG. 32, to simulate a thick breast under compression with a thickness of 9 cm. The double phantom also has a uniform distribution of glandular-to-adipose tissue mixture of 50:50. The SNR and mean glandular dose are presented for the double phantom using a monochromatic energy of 25 keV. The high SNR obtained on this model of a thick breast demonstrates that monochromatic x-rays can be used to examine women with reduced compression or no compression at all, since, typically, a compressed breast of 4.5 cm thickness is equivalent to an uncompressed breast of 8-9 cm thickness, as discussed in further detail below.
[0171] The experiments demonstrate that the mean glandular dose for the monochromatic measurements is always lower than that of the commercial machine for the same SNR. Stated in another way, the SNR for the monochromatic measurements is significantly higher than that of the commercial machines for the same mean glandular dose. Thus, monochromatic X-ray mammography provides a major advance over conventional broadband X-ray mammographic methods and has significant implications for diagnosing breast lesions in all women, and especially in those with thick or dense breast tissue. Dense breasts are characterized by non-uniform distributions of glandular tissue; this non-uniformity or variability introduces artifacts in the image and makes it more difficult to discern lesions. The increased SNR that monochromatic imaging provides makes it easier to see lesions in the presence of the inherent tissue variability in dense breasts, as discussed in further detail below.
[0172] FIG. 31 illustrates images of phantom 2900 obtained from a monochromatic x-ray source described herein using monochromatic Ag K (22 keV) and Sn K (25 keV) x-rays and an image from a conventional commercial mammography machine that uses broad band emission, along with respective histograms through the soft tissue blocks. The image from the commercial machine is shown in (a) of FIG. 31. The SNR for the 100% glandular block is 8.4 and the mean glandular dose (mgd) is 1.25 mGy (1 Gy=1 joule/kgm). Image (b) in FIG. 31 illustrates a monochromatic image using 22 keV x-rays and image (c) in FIG. 31 was obtained with 25 keV X-rays. The mean glandular doses for the 100% glandular block measured with 22 keV is 0.2 mGy and that measured with 25 keV is 0.08 mGy, and the SNR values are 8.7 for both energies. To achieve the same SNR as the commercial machine, the monochromatic system using 22 keV delivers a dose that is 6.7 times lower and using 25 keV delivers a dose that is 15 times lower.
[0173] The dose reduction provided by the monochromatic X-ray technology offers significantly better diagnostic detectability than the conventional broad band system because the SNR can be increased by factors of 3 to 6 times while remaining well below the regulatory dose limit of 3 mGy for screening. For example, the SNR value for the 22 keV images would be 21.8 at the same dose delivered by the commercial machine (1.25 mGy) and 32 for a dose of 2.75 mGy. Similarly, using the 25 keV energy, the SNR values would be 34 and 51 for mean glandular doses of 1.25 mGy and 2.75 mGy, respectively. This significantly enhanced range in SNR has enormous advantages for diagnosing women with dense breast tissue. As mentioned earlier, such tissue is very non-uniform and, unlike the uniform properties of the phantoms and women with normal density tissue, the variability in glandular distribution in dense breast introduces artifacts and image noise, thereby making it more difficult to discern lesions. The higher SNR provided by techniques describe herein can overcome these problems.
[0174] The monochromatic x-ray device incorporating the techniques described herein used to produce the images displayed here is comparable in size and footprint of a commercial broadband x-ray mammography system, producing for the first time low dose, high SNR, uniform images of a mammographic phantom using monochromatic x-rays with a degree of monochromaticity of 95%. In fact, conventional monochromatic x-ray apparatus do not even approach these levels of monochromaticity.
[0175] To simulate thick breast mammography, a model for thick breast tissue was created by placing two phantoms on top of each other (total thickness 9.0 cm), the 18-220 ACR Mammography Accreditation Phantom (3200) placed on top of the CIRS Model 011A phantom (2900), as shown in FIG. 32. For this series of experiments, 25 keV x-rays were selected to optimize the transmission while maintaining good contrast in the soft tissue represented by the 1 cm array of blocks embedded on the CIRS phantom. The images for the 25 keV monochromatic x-rays are compared to the images obtained from the same commercial broad band mammography machine used in the previous experiment. The resulting images are displayed in FIG. 33, along with the histograms of the contrast through the soft tissue blocks.
[0176] The image quality for the thick breast tissue is superior to anything obtainable with current commercial broad band systems. The dose delivered by the commercial machine is 2.75 mGy and only achieves a SNR of 3.8 in the 100% glandular block. The monochromatic image in FIG. 33 has a SNR=7.5 for a dose of 0.43 mGy. The dose required for the commercial broad band X-ray system to reach a SNR of 8.5, the accepted value of radiologists for successful detection in thinner 4.5 cm thick tissue would be 14 mGy, 11 times higher than the commercial dose used to image normal density breast tissue (1.25 mGy). This is prohibitively high and unsafe for screening and 4.7 times higher than the regulated MQSA screening limit. On the other hand, the required dose from the monochromatic system to achieve a SNR=8.5 is only 0.54 mGy, 26 times lower than that required by the commercial machine. The dose required using monochromatic x-rays is safe, more than 5 times lower than the regulatory limit, and still 2.5 times lower than the dose for normal thickness, 4.5 cm breasts using the commercial broad band x-ray mammography machine. Comparing the monochromatic X-ray and the commercial broad band X-ray machines at close to the maximum allowed exposure (2.75 mGy), the monochromatic technology provides 5 times higher SNR. The above discussion is summarized schematically in FIG. 34.
[0177] The measurements on the 9 cm thick breast phantom show that the monochromatic techniques described herein facilitate elimination of breast compression during mammography screening. A 4.5 cm compressed breast could be as thick at 9 cm when uncompressed. Whereas the commercial machine loses sensitivity as the breast thickness increases because it cannot increase the dose high enough to maintain the SNR and still remain below the regulated dose limit, the monochromatic x-ray system very easily provides the necessary SNR. As an example, of a monochromatic mammography procedure, a woman may lie prone on a clinic table designed to allow her breasts to extend through cutouts in the table. The monochromatic x-ray system may be designed to direct the x-rays parallel to the underside of the table. The table also facilitates improved radiation shielding for the patient by incorporating a layer of lead on the underside of the table's horizontal surface.
[0178] The inventor has recognized that the spatial resolution of the geometry of the monochromatic x-ray device described herein is excellent for mammographic applications. According to some embodiments, the monochromatic x-ray system has a source-to-detector distance of 760 mm, a secondary target cone with a 4 mm base diameter and 8 mm height, and an imaging detector of amorphous silicon with pixel sizes of 85 microns. This exemplary monochromatic x-ray device using the techniques described herein can easily resolve microcalicifications with diameters of 100-200 microns in the CIRS and ACR phantoms. FIGS. 35 and 36 illustrate images and associated histograms obtained using this exemplary monochromatic x-ray radiation device compared to images obtained using the same commercial device. The microcalcifications measured in the double ACR-CIRS phantom (stacked 2900 and 3200 phantoms) experiments described earlier using the monochromatic 25 keV x-ray lines have a SNR that is 50% higher than the SNR for the commercial machine and its mean glandular dose (mgd) is 6 times lower for these images. If one were to make the monochromatic SNR the same as that measured in the commercial machine, then the monochromatic mean glandular does (mgd) would be another factor of 2 times smaller for a total of 11 times lower.
[0179] Simple geometric considerations indicate that the effective projected spot size of the secondary cone is 1-2 mm. FIG. 37 illustrates histograms of the measured intensity scans through line-pair targets that are embedded in the CIRS phantom. The spacing of the line-par targets ranges from 5 lines per mm up to 20 lines per mm. The top four histograms show that the scans for 18 keV, 21 keV, 22 keV and 25 keV energies using a 4 mm secondary cone described briefly above can discern alternating intensity structure up to 9 lines per mm which is consistent with a spatial resolution FWHM of 110 microns. The 18 keV energy can still discern structure at 10 lines per mm. The bottom histogram in FIG. 37 is an intensity scan through the same line-pair ensemble using a commonly used commercial broad band mammography system. The commercial system's ability to discern structure fails beyond 8 lines per mm. This performance is consistent with the system's modulation transfer function (MTF), a property commonly used to describe the spatial frequency response of an imaging system or a component. It is defined as the contrast at a given spatial frequency relative to low frequencies and is shown in FIG. 38. The value of 0.25 at 9 lines/mm is comparable to other systems with direct detector systems and better than flat panel detectors.
[0180] According to some embodiments, the exemplary monochromatic system described herein was operated with up to 2000 watts in a continuous mode, i.e., the primary anode is water-cooled, the high voltage and filament current are on continuously and images are obtained using a timer-controlled, mechanical shutter. The x-ray flux data in FIG. 20 together with the phantom images shown in FIGS. 31 and 33 provide scaling guidelines for the power required to obtain a desired signal to noise for a specific exposure time in breast tissue of different compression thicknesses. Using a secondary material of Ag, 4 mm and 8 mm cone assemblies are compared for a compressed thickness of 4.5 cm and 50:50 glandular-adipose mix) in FIG. 39. The power requirements for a compressed thickness of 9 cm (50:50 glandular-adipose mix) as defined by experiments described above are compared in FIG. 40 for the 4 mm, 8 mm cones made from Sn.
[0181] The results indicate that a SNR of 8.5 obtained in a measurement of the 100% glandular block embedded in the CIRS phantom of normal breast density compressed to 4.5 cm can be achieved in a 5 second exposure expending 9.5 kW of power in the primary using the 4 mm cone (FIG. 39 top); 3.7 kW are needed if one uses the 8 mm cone (FIG. 39 bottom). In both of these cases, the source-to-detector (S-D) is 760 mm. If 2 sec are required, 9.2 kW are needed if an 8 mm cone is used or a 4 mm cone can be used at a source-to-detector (S-D) distance of 471 mm instead of 760 mm. Since the spatial resolution dependence is linear with S-D, then moving the 4 mm cone closer to the sample will only degrade the spatial resolution by 1.6 times, but it will still be better than the 8 mm cone at 760 mm. In general, there is a trade-off between spatial resolution and exposure time that will determine whether the 4 mm or 8 mm embodiments at the two source-to-detector distances best suit an application. This data serves as guides for designing monochromatic x-ray sources and do not exclude the possibilities for a variety of other target sizes and source-to-detector distances.
[0182] For thick breast tissue compressed to 9 cm, the dependency of the SNR on power is shown in FIG. 40. A 7 sec exposure can produce a SNR of 8.5 at 11 kW using a 4 mm Sn cone at a source-to-detector distance of 471 mm or with a 8 mm cone at 760 mm. Conventional broad band commercial mammography systems would have to deliver a 14 mGy dose to achieve this same SNR whereas the monochromatic system at 25 keV would only deliver 0.54 mGy, a factor of 26 times lower and still 2.3 times lower than the conventional dose of 1.25 mGy delivered by a commercial machine in screening women with normal density breast tissue compressed to 4.5 cm.
[0183] The inventor has recognized the importance of maximizing the monochromatic X-ray intensity in a compact x-ray generator for applications in medical imaging. Increased intensity allows shorter exposures which reduce motion artifacts and increase patient comfort. Alternatively, increased intensity can be used to provide increased SNR to enable the detection of less obvious features. There are three basic ways to increase the monochromatic flux: 1) maximizing fluorescence efficiency through the geometry of the target, 2) enhance the total power input on the primary in a steady state mode and 3) increase the total power input on the primary in a pulsed mode. The inventor has developed techniques to increase monochromatic flux corresponding to each.
[0184] With respect to improving fluorescence efficiency (which involves increasing the amount of fluorescent x-ray produced by a secondary target and/or decreasing the amount of fluorescent x-rays absorbed by the secondary target) via the geometry of the target, in analyzing the x-ray fluorescence phenomenon, the inventor recognized that conventional solid secondary targets contribute to inefficiency in producing monochromatic fluorescent x-ray flux emitted from the secondary target. In particular, broadband x-rays incident on a secondary target (e.g., the secondary targets described in the foregoing) are described by the Bremsstrahlung spectrum and characteristic lines emitted from the primary target. For example, FIG. 21 illustrates the spectrum 2100 emitted by a gold (Au) primary target (anode) for a 100 kVp cathode-anode voltage, including Bremsstrahlung emission 2100c and characteristic gold L and K-shell emissions 2100a and 2100b, respectively. Also illustrated in FIG. 21 are the K-absorption edges 2110a and 2110b for Ag (25 keV) and Sn (29 keV), respectively. The horizontal arrows 2115a and 2115b extending from the respective absorption edge energy to 100 keV illustrate photons in spectrum 2100 with energies above the respective absorption edges that are therefore candidates for inducing x-ray fluorescence from Ag and Sn targets, respectively.
[0185] As discussed in the foregoing, fluorescence occurs when photons are absorbed by an atom and electrons are ejected from the atom. As vacancies in the inner shell of the atom are filled by electrons from the outer shells, a characteristic fluorescent x-ray whose energy is the difference between the two binding energies of the corresponding shells (i.e., the difference between the binding energy of the outer shell from which an electron left and the binding energy of the inner shell in which a vacancy was filled) is emitted from the atom. The probability that a photon will be absorbed by secondary target material decreases approximately with the third power of the photon energy, thus the absorption length in the secondary target increases with photon energy. For example, 63% of 40 keV photons will be absorbed in the first 60 microns of Ag, whereas 170 microns and 360 microns are required to absorb 63% of 60 keV and 80 keV photons, respectively. The inventor has recognized that due to the fall off in the probability of absorption and the increase in absorption length as a function of photon energy, conventional solid secondary targets exhibit significantly reduced fluorescent x-ray flux because the secondary target itself absorbs a significant amount of the fluorescent x-rays that are generated in the interior of the secondary target.
[0186] FIG. 41 schematically illustrates this principle. In particular, in FIG. 41, two exemplary x-ray photons 4115a and 4115b are incident on a solid secondary target 4120. For example, x-rays 4115a and 4115b may be emitted from a primary target bombarded with electrons from a cathode of the primary stage of the x-ray source illustrated in FIG. 9 (e.g., x-rays 915 emitted by primary target 910 in response to electrons 907 emitted from cathode 905). With reference to the example spectrum illustrated in FIG. 21, x-rays 4115a and 4115b may be those emitted from a primary target comprising a gold surface and, therefore, exemplary x-rays 4115a and 4115b having energies above the absorption edge of the primary target material (e.g., above absorption edge 2110a for silver and above absorption edge 2110b for tin) and are therefore both candidates for producing fluorescent x-rays characteristic of the secondary target material.
[0187] As shown in FIG. 41, x-ray photon 4115a is absorbed near the surface of secondary target 4120, allowing fluorescent x-ray 4125a produced by the absorption event to escape secondary target 4120 before being absorbed (e.g., x-ray photon 4115a may be relatively close to the absorption edge of the secondary target material and therefore have a higher likelihood of being absorbed near the surface). As a result, fluorescent x-ray 4125a contributes to the monochromatic x-ray flux emitted from the secondary target and that can be utilized to perform imaging. That is, because the original absorption event occurred close to the surface of secondary target 4120, monochromatic fluorescent x-ray 4125a exits secondary target 4120.
[0188] On the other hand, x-ray photon 4115b penetrates further into secondary target 4120 before being absorbed (e.g., x-ray photon 4115b may have an energy further away from the absorption edge of the secondary target material and therefore have a lower probability of being absorbed near the surface). As a result of being absorbed in the interior of the secondary target, fluorescent x-ray 4125b is absorbed by secondary target 4120 and prevented from contributing to the monochromatic x-ray flux emitted from the secondary target and available for imaging. That is, because the original absorption event occurred deeper in the interior of secondary target 4120, monochromatic fluorescent x-ray 4125b is absorbed before it can exit secondary target 4120.
[0189] The inventor has appreciated that the geometry of conventional solid secondary targets in fact prevents significant amounts of fluorescent x-rays from exiting the secondary target and contributing to the available monochromatic x-ray flux, and has recognized that different geometries would allow substantial increases in monochromatic x-ray flux to be emitted from the secondary target. Accordingly, the inventor has developed secondary target geometries that substantially reduce the probability that monochromatic x-rays fluoresced by the secondary target will be absorbed by the secondary target, thereby increasing the monochromatic x-ray flux emitted from the secondary target and available to perform imaging.
[0190] According to some embodiments, the geometry of the secondary target increases the probability that an original absorption event occurs at or near a surface of the secondary target. For example, according to some embodiments, the number of opportunities an x-ray photon has to be absorbed near a surface of the secondary target is increased. As another example, according to some embodiments, the number of opportunities an x-ray photon has to be absorbed within an interior of the secondary target sufficiently distant from a surface of the secondary target is reduced and/or eliminated. The inventor has recognized that the above benefits may be achieved by using a secondary target comprising one or more layers of material instead of as a solid bulk target as is conventionally done. A layer refers herein to material provided as, for example, a sheet, foil, coating, film or veneer that can be applied, deposited or otherwise produced to be relatively thin, as opposed to conventional solid targets that are provided as bulk material. According to some embodiments, a secondary target comprises a plurality of layers, each providing an opportunity for incident x-rays to be absorbed at or near a surface of the secondary target, some illustrative examples of which are discussed in further detail below.
[0191] FIG. 42 illustrates a cross-section of a secondary target configured to increase monochromatic x-ray flux emitted from the secondary target, in accordance with some embodiments. In the example illustrated in FIG. 42, secondary target 4220 may be substantially the same shape and size as solid target 4120 illustrated in FIG. 41. However, instead of being constructed as a solid target (e.g., as bulk material), secondary target 4220 is constructed as a conical shell 4220a of secondary target material. The term shell is used herein to refer to one or more layers that form a given geometry (e.g., a conical shell, frustoconical shell, cylindrical shell, etc.). A shell may be open or closed and may be provided in any suitable form (e.g., as a foil, sheet, coating, film, veneer or other material layer), examples of which are described in further detail below.
[0192] Exemplary secondary target 4220 may be of foil construction of the desired secondary target material. The term foil refers herein to a thin layer of material that can be provided according to a desired geometry, further examples of which are discussed below. As a result of the layered nature of secondary target 4220 (e.g., via the foil construction), interior 4222 of secondary target 4220 provides substantially unobstructed transmission paths for x-rays that penetrate through the layers of the conical shell. For example, interior 4222 may be air or may include material substantially transparent to x-ray radiation (e.g., interior may include a substrate to support the secondary target material layer(s) (e.g., foil), or may be a substrate on which secondary target material is otherwise applied such via sputtering or other coating or deposition techniques, as discussed in further detail below.).
[0193] As with x-ray 4115a illustrated in FIG. 41, x-ray 4215a undergoes an initial (also referred to as an original or first) absorption event at or near the surface of secondary target 4220 and, as a result, fluorescent x-ray 4225a is emitted from the secondary target before it can be absorbed (i.e., before a second absorption event occurs). In the exemplary embodiment illustrated in FIG. 42, x-ray 4215a is absorbed within the material thickness of conical shell 4220a. Also, like x-ray 4115b illustrated in FIG. 41, x-ray 4215b penetrates into an interior of secondary target 4220. However, because interior 4222 is made of subject matter substantially transparent to x-rays (e.g., air, plastic, carbon fiber, etc.), x-ray 4215a is transmitted through the interior and undergoes an initial absorption event at or near another surface of secondary target 4220 (i.e., a layer of material on the other side of conical shell 4220a) instead of in the interior of the secondary target, as was the case with conventional solid secondary target 4120 illustrated in FIG. 41. Specifically, x-ray 4215 is transmitted through one layer of conical shell 4220a and interior 4222 and is absorbed by a layer of material on the other side of conical shell 4220a. As a result of this initial absorption event occurring at or near a surface of secondary target 4220, fluorescent x-ray 4225c produced in response to this absorption event exits secondary target 4220 and contributes to the monochromatic flux emitted from the secondary target.
[0194] The inventor has recognized that the thickness of the material layers of the secondary target impacts the efficiency of fluorescent x-ray production. While any thickness for a secondary target layer that increases the fluorescent x-ray flux relative to a solid secondary target may be suitable, the thickness of material layers can be generally optimized by considering the physics of x-ray transmission and absorption. FIG. 43 illustrates schematically an x-ray absorption and fluorescence event in connection with a layer of material having a thickness, t. In reference to FIG. 43, the intensity of x-rays transmitted through a thin layer of material (e.g., foil), I.sub.transmit, can be expressed as follows:
[00001]
[0195] In equation (1), E.sub.incident is the energy of the incident x-ray, u is the absorption coefficient at energy E.sub.incident, t is the thickness of the secondary target layer, and is the apex angle of the layer relative to the vertical direction. The amount of x-rays absorbed in the material layer, I.sub.absorb, is expressed below in equation (2) as follows:
[00002]
[0196] The absorbed x-rays will produce fluorescent x-rays characteristic of the absorbing material of the secondary target as discussed above. The amount of fluorescent x-rays that originate at the location, t/cos (), and escape from the secondary target is expressed below in equations (3) and (4) as follows:
[00003]
[0197] In equations (3) and (4), F.sub. is the efficiency of the fluorescent x-ray production. Accordingly, there is a thickness, t of the layer of material that maximizes the intensity of the escaping fluorescent x-rays. This can be normalized to the ratio, I.sub.escape/I.sub.incident F.sub., as shown below in equation (5) as follows:
[00004]
[0198] Using the equations above, plots 4400a and 4400b illustrated in FIGS. 44A and 44B, respectively, were obtained. Plots 4400a and 4400b show fluorescent x-ray emission (i.e., fluorescent x-ray intensity exiting a layer of secondary target material) as a function of material thickness at a number of exemplary incident x-ray photon energies, using silver (Ag) and tin (Sn) as the secondary target material layer, respectively. Specifically, plot 4400a illustrates fluorescent x-ray emission as a function of the thickness of a layer of Ag material arranged with an apex angle of 14 degrees relative to the vertical (i.e., =14 degrees) for exemplary primary x-ray energies of 40 keV, 50 keV, 60 keV, 80 keV and 100 keV. Similarly, plot 4400b fluorescent x-ray emissions for the same arrangement (geometry) but using instead a layer of Sn material. As demonstrated by plots 4400a and 4400b, each curve at the different primary x-ray energies exhibits a peak corresponding to the optimal thickness for the corresponding material layer. As shown, the optimal thickness at each exemplary energy is within a relatively narrow range. In particular, the optimal thickness for each energy ranges between 17 and 19 microns for the Ag layer and between 24 and 25 microns for the Sn layer.
[0199] Accordingly, the inventor has appreciated that selecting thicknesses within these ranges for a secondary target provides excellent fluorescent x-ray emission characteristics over a wide range of incident x-ray energies. It should be appreciated, however, that thicknesses outside the optimal range may also be used, as the aspects are not limited to selecting values within any particular range, let alone the optimal range for the particular secondary target material. That said, choosing thicknesses within the optimal range may produce secondary targets having better fluorescent x-ray emission characteristics, some examples of which are discussed in further detail below. Accordingly, the thickness of the layer(s) of secondary target material may be chosen based on the material type, the operating parameters of the monochromatic x-ray source and/or the intended application of the monochromatic x-rays. For example, the fluorescent emission vs. thickness curve for uranium has a peak corresponding to the optimal thickness of approximately 60 microns, but the characteristic curve is broader than the characteristic curves for Ag and Sn illustrated in FIGS. 44A and 44B, providing a much larger range of thicknesses exhibiting significantly improved fluorescent x-ray emission characteristics. As another example, molybdenum has a characteristic peak in its emission vs. thickness curve of approximately 13 microns. The choice of material thickness may also be based on the operating parameters of the monochromatic x-ray source. For example, thicker material layers may be preferable when using higher power devices to convert more of the higher energy x-rays emitted. Thus, exemplary secondary target material layers can range from 5 microns or less (e.g., down to micron) up to 200 microns or more. Typical secondary target material thicknesses for mammography diagnostic applications may range from approximately 10 microns or less to 50 microns or more, as an example. Secondary target material thickness may also be selected based on the number of material layers provided (e.g., material thickness may be reduced and additional layers added) to obtain desired fluorescent x-ray emission characteristics.
[0200] FIG. 45A illustrates an exemplary secondary target 4520 similar in geometry to secondary target 4220 illustrated in FIG. 42. In particular, secondary target 4520 is a conical shell of Sn having a total enclosed angle of 28 degrees (i.e., two times the apex angle of 14 degrees (=14) relative to the vertical), a width of 4 millimeters at its base (b=4 mm) and a material thickness of 25 microns (t=25 m). Secondary target 4520 (and 4520 in FIG. 45B) are oriented with the apex at the distal side of the secondary target and the base at the proximal side of the target. The terms distal and proximal refer herein to ends or sides closer to and farther away from the exit aperture of the monochromatic source (e.g., exit aperture 4544 illustrated in FIG. 45B). Accordingly, the distal side or distal end of a secondary target is the side that is closer to the exit aperture than the opposing side, which is referred to as the proximal side or proximal end. In FIG. 45A, the distal end of secondary target 4520 is indicated by arrow 4247 and the proximal end of secondary target 4520 is indicated by arrow 4245. Similarly, the terms distally and proximally refer herein to relative directions towards and away from the exit aperture (e.g., in the directions indicated by arrows 4247 and 4245, respectively).
[0201] The fluorescent x-ray emission from the exemplary secondary target illustrated in FIG. 45A was both simulated and measured experimentally, the results of which are illustrated in FIGS. 46 and 47, respectively. Specifically, for the simulation, x-ray fluorescence was computed using the equations above based on a model of a monochromatic x-ray source used to produce actual x-ray fluorescent emissions for the corresponding experiment discussed below. Additionally, fluorescent x-ray emissions were simulated (i.e., determined computationally) in the same manner for a conventional solid Sn secondary target of the same dimensions (i.e., a solid cone of tin having an apex angle of 14 degrees and a base of 4 mm). The simulated fluorescent x-ray emissions from the Sn foil secondary target (e.g., secondary target 4520) and the solid Sn target are illustrated in FIG. 46 discussed in further detail below.
[0202] To obtain experimental measurements, a conical shell secondary target 4520 was constructed using Sn foil having the approximate dimensions of secondary target 4520a illustrated in FIG. 45A. Specifically, an approximately 25 micron thick Sn foil conical shell was formed having a base width of approximately 4 mm and an apex angle of approximately 14 degrees, as illustrated schematically by secondary target 4520 illustrated in FIG. 45B. The Sn foil secondary target was positioned within a carrier and inserted into a monochromatic x-ray source (i.e., a monochromatic x-ray source as embodied by the aspects of the exemplary monochromatic x-ray sources described herein). Specifically, as illustrated schematically in FIG. 45B, a Sn foil target 4520 was positioned within carrier 4540 and inserted into a beryllium window 4530 that interfaces with the primary stage of a monochromatic x-ray source comprising primary target 4510 (gold plated tungsten) and cathode 4506 formed by a toroidal filament. The monochromatic x-ray source was operated by using 80 kV between the cathode 4506 and primary target 4510 with an emission current of 0.33 mA. Fluorescent x-rays emitted from the monochromatic source were detected using a cadmium telluride (CdTe) photon counting detector. Additionally, the same experiment was performed to obtain x-ray fluorescent measurements using a conventional sold Sn target having a base of 4 mm. As mentioned above, the simulations were performed using a model of the same physical system (i.e., the same monochromatic x-ray source and detector) and operational parameters employed to obtain actual fluorescent x-ray emission measurements to compare simulated results to actual measurements.
[0203] FIGS. 46 and 47 illustrate the fluorescent x-ray emissions obtained via the simulations and actual experiments discussed above, respectively. Specifically, simulated emissions 4625a and 4625b show the simulated K and K fluorescent x-ray emissions for the Sn conical shell secondary target (i.e., secondary target 4520 illustrated schematically in FIG. 45A), respectively. Simulated emissions 4625a and 4625b show the simulated K and K fluorescent x-ray emissions for the Sn solid cone secondary target, respectively. Similarly, measured emissions 4725a and 4725b show the actual K and K fluorescent x-ray emissions measured for the Sn conical shell secondary target (i.e., secondary target 4520 illustrated schematically in FIG. 45B), respectively, and measured emissions 4725a and 4725b show the actual K and K fluorescent x-ray emissions measured for the Sn solid cone secondary target, respectively. As shown, the simulated and measured fluorescent x-ray emissions for the Sn conical shell secondary target are significantly increased relative to the corresponding emissions for the Sn solid cone secondary target. Notably, the simulated and experimental results are in substantial agreement, demonstrating the veracity of the simulations.
[0204] It should be appreciated that the dimension of the secondary target discussed above is merely exemplary and can be chosen as desired. For example, the maximum diameter of the secondary target (e.g., the diameter of the base of secondary target 4220) can be chosen based on the requirements of the monochromatic x-ray source. In particular, the larger the secondary target the greater the monochromatic x-ray flux that can be produced. However, the larger the secondary target, the larger the spot size of the fluorescent x-ray source, resulting in decreased spatial resolution of the resulting images. As such, there is typically a trade-off in increasing or decreasing the size of the secondary target (i.e., the larger the secondary target the greater the fluorescent x-ray intensity and the smaller the secondary target the better the resulting spatial resolution, all other operating parameters held the same. Thus, for applications in which fluorescent x-ray intensity may be more important than optimal spatial resolution, larger secondary targets may be preferred, for example, secondary targets having a maximum diameter of 8 mm, 10 mm, 15 mm or larger. By contrast, for applications in which spatial resolution is paramount, smaller secondary targets may be preferred, for example, secondary targets having a maximum diameter of 4 mm, 2 mm, 1 mm or smaller. As depicted in the drawings herein, the maximum diameter refers to the width of the secondary target at its maximum (e.g., in a direction orthogonal to the longitudinal axis of the secondary target). For example, the maximum diameter for a conical, cylindrical or spiral shell corresponds to the diameter of the shell at its base, whether the base is oriented distally or proximally.
[0205] According to some embodiments, a secondary target has a maximum diameter of less than or equal to approximately 10 mm and greater than or equal to approximately 8 mm, according to some embodiments, a secondary target has a maximum diameter of less than or equal to approximately 8 mm and greater than or equal to approximately 6 mm, according to some embodiments, the secondary target has a maximum diameter of less than or equal to approximately 6 mm and greater than or equal to approximately 4 mm, according to some embodiments, the secondary target has a maximum diameter of less than or equal to approximately 4 mm and greater than or equal to approximately 2 mm, and according to some embodiments, the secondary target has a maximum diameter of less than or equal to approximately 2 mm and greater than or equal to approximately 1 mm. According to other embodiments, a secondary target has a maximum diameter of greater than 10 mm and according to other embodiments a secondary target has a maximum diameter of less than 1 mm.
[0206] It should be appreciated that the above dimensions are merely exemplary and larger or smaller secondary targets may be used, as the aspects are not limited in this respect. Additionally, the size of a secondary target can be varied in other ways, for example, by changing the height (i.e., the maximum dimension in a direction parallel to the longitudinal axis) to base aspect ratio (e.g., height to maximum diameter ratio). A change in the aspect ratio generally has a corresponding change to the apex angle. Thus it should be appreciated that different apex angles may be selected as desired, ranging from 0 degrees (i.e., vertical layers) to 90 degrees (i.e., a horizontal layers), as the aspects are not limited in this respect.
[0207] According to some embodiments, a secondary target has an aspect ratio (e.g., using any of the exemplary diameters discussed above) of between 1:2 and 1:1, according to some embodiments, the secondary target has as aspects ratio between 1:1 and 2:1, according to some embodiments, the secondary target has an aspect ratio of between 2:1 and 3:1, according to some embodiments, the secondary target has an aspect ratio of between 3:1 and 4:1, according to some embodiments, the secondary target has an aspect ratio of between 4:1 and 5:1, according to some embodiments, the secondary target has an aspect ratio of between 5:1 and 6:1, according to some embodiments, the secondary target has an aspect ratio of between 6:1 and 7:1, and according to some embodiments, the secondary target has an aspect ratio of between 7:1 and 8:1. It should further be appreciated that the above aspect ratios are exemplary and other aspects ratios may be chosen, as the aspects are not limited in this respect.
[0208] As demonstrated above, using a layer of secondary target material instead of a solid target may significantly increase fluorescent x-ray flux, as demonstrated by the above simulations and experiments. However, the inventor has appreciated that even at the optimal thickness for the secondary target material, some fraction of incident x-rays will pass through the secondary target without being absorbed by the secondary target, and the potential of producing a monochromatic x-rays from these transmitted x-rays is therefore lost. For example, FIG. 48 illustrates a conical shell secondary target 4820 similar or the same as secondary target 4220 illustrated in FIG. 42. As shown, while some of the incident x-rays are converted to fluorescent x-rays, a number of incident primary x-rays pass through the secondary target without being absorbed. As a result, the potential of generating monochromatic fluorescent x-rays from these transmitted x-rays is lost (e.g. incident x-rays 4815a-f emitted from a primary targeted are transmitted through secondary target 4820 without being absorbed).
[0209] The inventor has recognized that more of the available incident x-rays (e.g., broadband x-rays emitted from a primary target) can be converted to monochromatic fluorescent x-rays by including additional layers of secondary target material, thereby providing additional opportunities for x-rays to undergo an initial absorption event near a surface of the secondary target. More particularly, the inventor has recognized that using multiple layers of secondary target material increases the total absorption probability of incident x-rays while maintaining short path lengths for the resulting fluorescent x-rays to exit the secondary target. This multiple layer geometry also makes it possible to take better advantage of higher energy x-rays present in the incident broadband spectrum (i.e., the higher energy photons in the Bremsstralung spectrum) which would ordinarily be absorbed deep inside a solid secondary target where the resulting fluorescent x-rays have a very low probability of escaping (i.e., exiting the secondary target to contribute to the monochromatic x-ray flux). According to some embodiments, a plurality of nested layers of secondary target material is used to increase monochromatic x-ray flux emission from the secondary target.
[0210] FIGS. 49A and 49B illustrate cross-sections of exemplary secondary targets comprising nested conical shells providing a plurality of layers of secondary target material to increase the probability of an absorption event occurring at or near a surface of the secondary target material. In particular, secondary target 4920 comprises an outer conical shell 4920a and an inner conical shell 4920b, both formed substantially in the shape of a cone in the embodiment illustrated in FIGS. 49A and 49B. By nesting a plurality of shells, additional layers of secondary target material is disposed in the transmission paths of x-rays incident on the secondary target, increasing the number of opportunities for, and thus the probability that, an incident x-ray will undergo an initial absorption event in one of the plurality of layers of secondary target material. Because each of the plurality of layers is relatively thin (e.g., within the optimal range for the corresponding material), the number of initial absorption events occurring at or near a surface of the secondary target material is increased, thereby increasing the amount of monochromatic x-ray flux that exits the secondary target.
[0211] According to some embodiments, each of the plurality of layers has a thickness that falls within an optimal range, for example, a thickness that generally maximizes fluorescent x-ray emission for the respective type of material used, as determined in the manner discussed above. However, it should be appreciated that the thickness of the plurality of layers may be outside the optimal range and can be of any thickness, as the aspects are not limited in this respect. Additionally, the plurality of layers may have the same, substantially the same or different thicknesses. For example, in the embodiment illustrated in FIGS. 49A and 49B, outer conical shell 4920a and inner conical shell 4920b may be constructed having the same thickness (or substantially the same thickness) or may be constructed having different thicknesses, as the aspects are not limited in this respect.
[0212] As discussed above, using nested conical shells increases the probability that incident x-rays will be absorbed by the secondary target. For example, comparing FIG. 48 and FIG. 49A, broadband x-rays 4815a, 4815c, 4815d, 4815e and 4815f that were transmitted through secondary target 4820 were absorbed by secondary target 4920 and, more specifically, by inner conical shell 4920b, thereby producing additional fluorescent x-rays with the potential of exiting the secondary target 4920. However, the inventor recognized that while the layers of secondary target material provide additional opportunities for broadband x-rays to undergo an initial absorption event, the additional layers also present further opportunities for the resulting fluorescent x-rays to be absorbed before exiting the secondary target. For example, as illustrated in FIG. 49B, broadband x-rays 4815d and 4815e, which were transmitted through secondary target 4820 but absorbed by inner conical shell 4920b, produce fluorescent x-rays 4925d and 4925e that are absorbed by the material layers of secondary target 4920 before exiting the secondary target. That is, because the distal end of the exemplary nested conical shells illustrated in FIGS. 42, 48 and 49 are generally closed, some amount of fluorescent x-rays will be absorbed and prevented from exiting the secondary target. Thus, though broadband x-rays 4815d and 4815e underwent an initial absorption event at or near a surface of secondary target 4920 (i.e., at or near the surface of inner conical shell 4920b), the resulting fluorescent monochromatic x-rays 4925d and 4925e were absorbed by inner conical shell 4920b and outer conical shell 4920a, respectively, before exiting secondary target 4920.
[0213] To facilitate a further increase in the fluorescent x-ray flux exiting a secondary target, the inventor has developed geometries that decrease the probability that fluorescent x-rays will be absorbed by second target material before exiting the secondary target and contributing to the monochromatic x-ray flux. According to some embodiments, a secondary target is constructed to have one or more openings in at least one layer of secondary target material to allow fluorescent x-rays to exit the secondary target unimpeded (i.e., without having to be pass through further material layers). For example, the distal end of the secondary target may be opened or partially opened to allow unobstructed transmission of at least some fluorescent x-rays produced in response to initial absorption events of incident x-rays. According to some embodiments, one or more conical shells may be inverted to reduce obstructions to fluorescent x-ray transmission (e.g., one or more conical shell may be arranged with its apex on the proximal side of the secondary target). According to some embodiments, cylindrical or spiral shells are provided to generally open the distal end of the secondary target. Some illustrative examples of secondary targets with open geometries are discussed in further detail below.
[0214] FIG. 50A illustrates a secondary target 5020 comprising nested shells 5020a and 5020b, wherein outer shell 5020a is constructed as a frustoconical shell open at the distal end to provide unimpeded transmission paths for an increased number of fluorescent x-rays produced at layers internal to the secondary target (e.g., produced as a result of broadband x-ray absorption by inner conical shell 5020b). Compared with the exemplary fluorescent x-rays absorbed by secondary target 4920 illustrated in FIGS. 49A and 49B, fluorescent x-ray 4925e exits secondary target 5020 unimpeded via the open distal end of frustoconical shell 5020a, instead of being absorbed by the outer shell (e.g., outer conical shell 4920a of secondary target 4920 illustrated in FIGS. 49A and 49B), thereby increasing the fluorescent x-ray flux emitted by secondary target 5020. However, fluorescent x-ray 4925d is still absorbed by inner conical shell 5020b.
[0215] FIG. 50B illustrates a secondary target 5020 in which both the inner and outer shells (e.g., inner shell 5020b and outer shell 5020a) are frustoconical, providing at least some unimpeded transmission paths from the inside of both shells and thereby reducing the probability that fluorescent monochromatic x-rays will be absorbed by the secondary target. For example, fluorescent x-ray 4925d, which is illustrated as being absorbed by inner conical shell 5020b in FIG. 50a, exits unimpeded via the opening at the distal end of inner frustoconical shell 5020b. Accordingly, by opening one or more nested shells, the probability that fluorescent x-rays are absorbed by the secondary target can be reduced. It should be appreciated, however, that frustoconical shells reduce the probability of fluorescent x-ray absorption but also reduce the surface area of the secondary target available for initial absorption events of incident x-rays (e.g., broadband x-rays emitted by the primary target), thus potentially reducing the number of fluorescent x-rays produced by the secondary target. The inventor has appreciated that by inverting one or more conical shells of a secondary target, the amount of unimpeded transmission paths can be increased without a corresponding loss in surface area.
[0216] FIG. 51 illustrates a secondary target 5120 in which an outer shell has been inverted to decrease the probability that fluorescent x-rays produced by the layers of secondary target material will also be absorbed by those layers. In particular, secondary target 5120 is constructed using an inner conical shell 5120b (e.g., a conical shell similar in geometry to the exemplary inner conical shells illustrated in FIGS. 49A, 49B and 50A). Outer shell 5120a is formed by a conical or frustoconical shell that is inverted relative to inner conical shell 5120b, thereby providing unimpeded transmission paths for an increased number of fluorescent x-rays produced by secondary target 5120 (e.g., produced in response to absorbing broadband x-rays from a primary target.) By inverting outer shell 5120a (e.g., by orienting the outer shell so that the apex-side of the shell is at or toward the proximal end of the secondary target instead of the distal end), the probability of fluorescent x-ray absorption can be decreased without reducing the surface area of the secondary target available to absorb primary x-rays (e.g., broadband x-rays emitted by a primary target). Thus, the generally W shaped geometry of exemplary secondary target 5120 facilitates significantly increasing the fluorescent x-ray intensity emitted by the secondary target, as demonstrated in further detail below.
[0217] FIG. 52 illustrates a secondary target 5220 in which both the inner and outer shells have been inverted so that the apex-side of the respective shells are oriented toward the proximal end of the secondary target. Specifically, secondary target 5220 is constructed using inner conical shell 5220b having its apex directed toward the proximal end of the secondary target (i.e., generally inverted relative to the orientation of inner conical shell 5120b of secondary target 5120) and outer shell 5220a also oriented towards the proximal end in the direction of outer shell 5120a of exemplary secondary target 5220. As another variation using an open geometry, FIG. 53 illustrates a secondary target 5320 in which both outer shell 5320a and inner shell 5320b have a generally conical shape and are oriented with their respective apexes directed towards the proximal end of the secondary stage. It is noted that while the exemplary secondary targets illustrated in FIGS. 51, 52 and 53 have two nested shells, any number of shells may be used, including a single shell (e.g., the single conical shell of exemplary secondary target 4520b illustrated in FIG. 45B may be inverted so that its apex is directed toward the proximal end of the secondary target instead of toward the distal end, with the base optional opened).
[0218] Based on the insight provided by the inventor, numerous other open geometries are also possible. For example, FIGS. 54A-C illustrate exemplary secondary targets formed from generally cylindrical shells. In particular, exemplary secondary targets 5420 and 5420 are constructed using an outer cylindrical shell 5420a and inner cylindrical shell 5420b open at the distal end to decrease the probability of fluorescent x-rays produced from initial absorption of broadband x-rays being absorbed by the secondary target. FIG. 54B illustrates a top down view of secondary targets 5420 and 5420 showing outer cylindrical shell 5420a and inner shell 5420b. As further illustrated, secondary target 5420 illustrated in FIG. 54A includes secondary target material at the proximal end of the secondary target (e.g., the inner and outer shells may be closed or substantially closed at the proximal end), while secondary target 5420 illustrated in FIG. 54C is open at the proximal end. As discussed above in connection with conical or frustoconical shells, any number of cylindrical shells may be used to construct the secondary target, as the aspects are not limited in this respect.
[0219] As another generally open geometry variation, FIGS. 55A-C illustrate secondary targets constructed using a spiral geometry. In particular, secondary target 5520 illustrated in FIG. 55A comprises cylindrical spiral 5520a and secondary target 5520 illustrated in FIG. 55C comprises conical spiral 5520a. While a conical spiral is illustrated in FIG. 55C, a frustoconical (not shown) spiral may be more easily manufactured. FIG. 54B illustrates a top down view of a cross-section of secondary targets 5520 and 5520 showing the characteristic spiral geometry of the secondary targets. As with the number of nested shells, a spiral geometry can have any number of turns to provide a desired number of layers of secondary target material to provide sufficient opportunity for incident broadband radiation to undergo an initial absorption event at or near a surface of the secondary target (i.e., sufficient opportunity to be absorbed by one of the layers of material forming the secondary target), as the aspects are not limited in this respect.
[0220] A number of the exemplary secondary targets described in the foregoing include secondary target material on the proximal side of the secondary target (e.g., side 4220c of secondary target 4220 illustrated in FIG. 42). However, as an alternative, the proximal side of the secondary target may be left open and/or generally free of secondary target material. For example, FIGS. 56-59 illustrate secondary targets 5620, 5720, 5820 and 5920 that are substantially open on the proximal side of the secondary target. This may simplify construction of the secondary target.
[0221] As also discussed in the foregoing, a plurality of layers may be used to increase the probability that broadband x-rays will be absorbed and any number of layers may be employed. For example, FIGS. 60A-C and 61A-C illustrate secondary targets configured with different number of layers of secondary target material using a conical geometry and an inverted conical geometry, respectively. In particular, FIG. 60A illustrates a single conical shell secondary target 6020 in which x-rays passing through the secondary target (e.g., along axis 6053 orthogonal to the longitudinal axis 6055 of the monochromatic x-ray source) typically encounter two layers of secondary target material. Secondary target 6020 illustrated in FIG. 60B is constructed of two nested conical shells and therefore provides four layers of secondary target material for x-rays passing through the target, and secondary target 6020 illustrated in FIG. 60C is constructed from three nested conical shells presenting six layers of secondary target material that provide opportunities for broadband x-rays to be absorbed.
[0222] Similarly, FIGS. 61A-C illustrate secondary targets constructed using an open (e.g., inverted shell) geometry. In particular, secondary target 6120 illustrated in FIG. 61A is constructed using a generally W shape, providing four layers of secondary target material to absorb incident broadband x-rays (e.g., secondary target 6120 comprises four separate layers in the direction orthogonal to the longitudinal axis of the secondary target so that many (if not most) incident x-rays will have four opportunities to undergo an initial absorption event). Secondary targets 6120 and 6120 illustrated in FIGS. 61B and 61C, respectively, are constructed with nested inverted conical shells, both providing six layers of secondary target material capable of absorbing incident broadband x-ray radiation. Referring to FIG. 55C, secondary target 5520 constructed using a spiral geometry provides seven layers of secondary target material capable absorbing primary x-rays emitted from a primary target to produce fluorescent x-rays. As discussed above, the secondary targets illustrated herein are exemplary and any number of layers may be used to construct a secondary target, as the aspects are not limited in this respect. Increasing the number of layers may facilitate converting more high energy incident x-rays to fluorescent x-rays.
[0223] As illustrated by the exemplary secondary targets illustrated in FIGS. 60A-C and 61A-C, each successive shell has a different apex angle (e.g., by virtue of having different aspect ratios). This change in apex angle is more clearly illustrated by exemplary secondary targets 6220 and 6220 in FIGS. 60D and 60E, where a relatively wide apex angle is used to construct the generally conical shells. In particular, outer shell 6220a of exemplary target 6220 illustrated in FIG. 60D has an apex angle of approximately 60 degrees while inner shell 6220b has an apex angle of approximately 30 degrees. A progression from relatively large apex angle to smaller apex angle can also be seen by the decreasing apex angles of outer, middle and inner shells 6220a, 6220b and 6220c of exemplary secondary target 6220 illustrated in FIG. 60E. FIG. 60F illustrates an exemplary secondary target 6220 with a plurality of nested shells in which the apex angle is substantially the same for both outer shell 6220a and inner shell 6220b. It should be appreciated that a secondary target can be constructed to have any desired apex angle or apex angles depending on the geometry of the one or more shells, including the boundary angles of 0 degrees (i.e., vertical layer(s) resulting, for example, by the cylindrical shells illustrated in FIGS. 54A-C or by lining up planar layers of secondary material layers in the horizontal direction) and 90 degrees (i.e., horizontal layer(s) resulting, for example, by rotating the cylindrical shells illustrated in 54A-C by 90 degrees or by stacking planar layers of secondary target material in the vertical direction with a desired amount of spacing between the successive layers). It should be appreciated that varying the apex angle applies to other geometries as well, including the W shaped geometries illustrated in FIGS. 61A-C.
[0224] To illustrate the efficacy of using layered secondary targets, FIG. 62 shows the monochromatic fluorescent x-ray flux output emitted from secondary targets using a number of different geometries relative to the monochromatic fluorescent x-ray flux emitted from a conventional solid cone secondary target. The monochromatic fluorescent x-ray intensity shown in FIG. 62 was simulated using silver (Ag) as the secondary target material and the layered secondary targets were simulated with each layer formed by a 17 micron thick Ag foil. As shown in FIG. 62, monochromatic fluorescent x-ray flux emitted by solid conical secondary target 6220A was normalized to one. Secondary target 6220B, comprising a single conical shell, produced twice the monochromatic fluorescent x-ray intensity and secondary target 6220C, comprising nested conical shells, produced 2.5 times the monochromatic fluorescent x-ray intensity as conventional solid secondary target 6220A. Secondary target 6220D, comprising inverted nested shells in a generally W shaped geometry provided a factor of 3.2 times the monochromatic fluorescent x-ray flux compare to the conventional solid cone secondary target 6220A. The increase in monochromatic fluorescent x-ray intensity produced using techniques described herein has a significant impact on the power requirements of the x-ray source, reducing the input power required at the primary cathode-anode stage to produce the same monochromatic x-ray flux at the output of a monochromatic x-ray source, as discussed in further detail below.
[0225] The secondary target material provided in the exemplary geometries discussed in the foregoing may be provided on a support or substrate to provide a secondary target that can be relatively easily handled and positioned to form the secondary stage of a monochromatic x-ray source. FIGS. 63A and 63B illustrate an exemplary support secondary target material, in accordance with some embodiments. In the example illustrated in FIGS. 63A and 63B, a support 6322 for nested conical shells of secondary target material is provided comprising an outer support 6322a for outer conical shell 6320a and an inner support 6322b for inner conical shell 6320b. Outer support 6322a includes a substrate 6324a and inner support 6322b includes a substrate 6324b on which secondary target material (e.g., a metallic fluorescer) can be applied to form inner and outer nested conical shells, respectively. Support 6322 (e.g., inner and outer supports 6322a and 6322b) may be made of any suitable material, for example, a generally low atomic number material that is sufficiently transparent to both incident broadband x-rays and fluorescent x-rays produced by the secondary target. For example, the support can be constructed using carbon fiber, nylon, polyethylene, boron nitride, aluminum, silicon or any other suitable material. The support for the secondary target material (e.g., support 6322) may be manufactured using any suitable technique, for example, 3D-printing, machining, material growth, casting, molding, etc.
[0226] Moreover, secondary target material may be applied to the substrate surfaces of the secondary target support in any suitable manner. For example, thin foil may be attached or otherwise affixed to the substrate(s) of the support to form the secondary target (e.g., to form inner and outer conical nested foils). Alternatively, if free-standing foils are not the optimum choice, for example, secondary target material may be applied using any suitable deposition technique, such as evaporation, sputtering, epitaxial growth, electroplating or any other suitable material deposition process. For example, some secondary target material may be difficult to produce in thin-foil form, but can be readily deposited using deposition techniques commonly used in semiconductor and MEMS fabrication. Thus, deposition methods make it possible to utilize materials for the secondary target that are not available as free-standing thin foils or not easily machineable, e.g. antimony, tellurium which are useful for x-ray mammography. Higher Z materials, which are applicable, but not limited to cardiac or thorasic imaging, can be made from rare earth elements (e.g., dysprosium, holmium) or higher Z elements (e.g., tantalum, tungsten, platinum or depleted uranium).
[0227] The exemplary support illustrated in FIGS. 63A and 63B may be constructed using hollow conical supports 6322a and 6322b, though the support could also be formed using solid pieces of support material or a combination of solid and hollow support pieces. As illustrated in FIG. 63B, outer support 6322a comprises (in addition to substrate portion 6324a on which secondary target material is applied) base portion 6324c having a groove or other interlocking portion 6324d and a platform portion 6324e that together cooperate with inner support 6322b to allow the inner support to be correctly positioned and snapped into place. In particular, platform 6324e engages with base portion 6324f of inner support 6322b to limit how far the inner support 6322b can be inserted into the outer support 6322a in the direction indicated by arrow 6355. In addition, cooperating portion 6324g engages with the interlocking portion 6324d of base 6324c to snap the inner support to the outer support to nest inner conical shell 6320b within outer conical shell 6320a, thereby forming a nested conical shell secondary target. It should be appreciated that the support may be formed from a single integrated piece of material, or may provide a substrate on which to apply secondary target material in other ways, as the aspects are not limited in this respect.
[0228] FIGS. 64 and 65 illustrate two exemplary secondary targets arranged within a carrier positioned within a window of a monochromatic x-ray source. Specifically, carrier 6440 may be the same or similar to any of the carriers described herein that, when housing a secondary target, forms the secondary stage of a monochromatic x-ray source. It should be appreciated that carrier 6440 may utilize any of the techniques described herein. For example, carrier 6440 may include a blocking portion 6444 and a transmissive portion 6442 in which the secondary target is positioned (e.g., exemplary secondary targets 6420 and 6520). The blocking portion may comprise material that blocks x-ray radiation so that substantially all of the x-rays emitted from the monochromatic x-ray source exit via exit aperture 6544c, details of which were described in the foregoing. Transmissive portion 6442 may be constructed of material that is generally transparent to x-rays, as also discussed in detail herein.
[0229] It should be appreciated that carrier 6440 may be removable from the first stage of the monochromatic x-ray source or may be provided as integrated components of the monochromatic x-ray source that are not generally removable. Moreover, it should be appreciated that layered secondary targets (e.g., exemplary secondary targets 6420 and 6520) can be employed in a monochromatic x-ray source in other ways without using the exemplary carriers described herein. In FIGS. 64 and 65, exemplary carrier 6440 is shown positioned within window 6430 that provides an interface to the primary stage of the monochromatic x-ray source and, more particularly, to primary target 6410 and cathode 6406. In FIG. 64, secondary target 6420 is constructed using a nested conical shell geometry, for example, any of the geometries illustrated in FIGS. 49A-B, 50A-B, 60A-C, etc. In FIG. 65, secondary target 6520 is constructed using an inverted or W shaped geometry, for example, any of the open geometries illustrated in FIGS. 51-53, 61A-C, etc.
[0230] Referring to FIG. 65, the inverted geometry of secondary target 6520 may allow for advantageous modification to the carrier by, for example, eliminating the need for at least part of the carrier of the secondary stage. In particular, because the maximum dimension of secondary target 6520 (or other inverted geometries) is at the distal end of the secondary target, the distal end can be supported by the distal end of the carrier (e.g., a blocking portion of the carrier). As a result, the transmissive portion (e.g., transmissive portions 1342 and 1742 illustrated in FIGS. 13A-C and 17A-C, respectively) can be eliminated in some embodiments, removing material that can potentially interact with primary x-rays from the primary target, fluorescent x-rays from the secondary target, or both. In particular, the support or substrate on which secondary material is applied may also provide the proximal portion of the carrier that connects to or couples with the distal end of the carrier (e.g., the blocking portion in embodiments in which such techniques are used).
[0231] For example, FIGS. 66A and 66B illustrate a carrier 6640 for a layered secondary target 6620 having an inverted geometry in which the maximal diameter of the target is on the distal side of the secondary target. Carrier 6640 includes a distal portion 6644 comprising an exit aperture 6644c through which fluorescent x-rays are emitted from the monochromatic x-ray source. Distal portion may be constructed in any suitable manner and, for example, may be constructed of blocking material as described in the foregoing. Carrier 6640 also comprises proximal portion 6642 comprising secondary target 6620. Specifically, the secondary target itself generally forms the proximal portion of carrier 6640. For example, as illustrated in FIG. 66B, proximal portion 6642 may comprise an outer support 6642 on which secondary target material is applied to form outer shell 6620a and an inner support 6642b on which secondary target material is applied to form inner shell 6620b.
[0232] It should be appreciated that supports 6642a and 6642b may be constructed using any of the techniques described herein (e.g., 3D printing, machining, casting, etc.) and may be formed using any of the materials described herein (e.g., relatively low atomic number material that is substantially transparent to x-ray radiation.). Similarly, secondary target material may be applied using any technique described herein to form the layers of secondary target (e.g., to form exemplary outer shell 6620a and inner shell 6620b illustrated in FIGS. 66A and 66B). The distal and proximal portions of carrier 6640 may include cooperating portions that allow the two portions to be coupled. For example, distal portion 6644 may include a cooperating portion 6644d and proximal portion 6642 may include a cooperating portion 6642d that can be removably coupled (e.g., snapped together) so that different secondary targets can be coupled to the distal portion 6644 of carrier 6640. Thus, in the exemplary carrier 6640 illustrated in FIGS. 66A and 66B, the secondary target 6620 is part of the proximal portion as opposed to being a separate component from the transmissive portion of the carrier.
[0233] As discussed above, the intensity of monochromatic x-ray emission may also be increased by varying the operating parameters of the first stage of the monochromatic source, for example, by increasing the cathode-anode voltage (e.g., the voltage potential between filament 6406 and primary target 6410 illustrated in FIGS. 64 and 65) and/or by increasing the filament current which, in turn, increases the emission current of electrons emitted by the filament. To further illustrate the monochromatic x-ray flux increase using layered secondary targets, FIG. 67 plots x-ray intensity against emission current at a number of different cathode-anode voltages using three different secondary target types: 1) an Ag solid cone having a 4 mm diameter base (see lines 65a, 65b and 65c); 2) an Ag solid cone having a 8 mm diameter base (see lines 67a, 67b and 67c); and 3) a thin foil W shaped target having a base diameter of 4 mm, i.e., the diameter at the distal end of the inverted shell (see lines 69a, 69b and 69c).
[0234] As shown, the W shaped geometry of the layered secondary target produces substantially more fluorescent x-ray flux at the same cathode-anode voltage and, in fact, produces a higher fluorescent x-ray flux at 60 k Vp than the 4 mm solid cone produces at 100 k Vp. The layered secondary target (i.e., the 4 mm W shaped target) also produces more monochromatic x-ray flux than the 8 mm solid cone at 60 kVp despite the larger surface area of the 8 mm solid cone. Accordingly, layered secondary targets provide significant advances over conventional secondary targets with respect to fluorescent x-ray intensity production. More specifically, the curves in FIG. 67 show that the layered secondary target having a W shaped geometry for a 4 mm diameter conical base provides an intensity that is 25% larger than the intensity from the 8 mm diameter solid cone. Since the 4 mm diameter cone provides better spatial imaging resolution than the 8 mm solid cone, the W shaped geometry provides increased fluorescent x-ray intensity while maintaining the spatial imaging resolution of the 4 mm diameter solid conc.
[0235] To increase the power and further decrease the exposure times, power levels of 10 kW-50 KW may be used. The projected power requirements for the layered secondary target with W shaped geometry embodiment is compared to the power requirements of the solid conical targets illustrated in FIGS. 68-71, which solid conical target were examined and compared to a commercial machine in FIGS. 39 and 40. FIG. 39 illustrated the power requirements for a 4.5 cm compressed breast and FIG. 40 the requirements for a 9 cm compressed breast. As shown in FIGS. 68-71, power requirements for the layered secondary target (W shaped geometry) is significantly reduced from the solid secondary targets to achieve the same signal-to-noise ratio, which already provides a significant improvement over commercial machines. FIGS. 68 and 69 illustrate the improvements for a 4.5 cm compressed breast and FIGS. 70-71 the improvements for a 9 cm compressed breast.
[0236] As discussed above, to increase the power and further decrease the exposure times, power levels of 10 kW-50 KW may be used. For example, an electron beam in high power commercial medical x-ray tubes (i.e., broadband x-ray tubes) has approximately a 17 mm fan shape as it strikes an anode that is rotating at 10,000 rpm. Since the anode is at a steep angle to the electron beam, the projected spot size in the long direction as seen by the viewer is reduced to about 1 mm. For an exposure of 1 sec, once can consider the entire annulus swept out by the fan beam as the incident surface for electron bombardment. For a 70 mm diameter anode, this track length is 210 mm, so the total incident anode surface area is about 1400 mm.sup.2. For the monochromatic system using a conical anode with a 36 mm diameter and a truncated height of 6 mm, the total area of incidence for the electrons is 1000 mm.sup.2. Therefore, it should be straightforward to make a 1 sec exposure at a power level that is 70% of the power of strong medical sources without damaging the anode material; 100 KW is a typical power of the highest power medical sources. Assuming a very conservative value that is 50% of the highest power, an anode made of a composite material operating at 50 kW should be achievable for short exposures. This is more power than is needed for thick and/or dense breast diagnostics but offers significant flexibility if reducing the effective size of the secondary cone becomes a priority.
[0237] A one second exposure at 50 kW generates 50 kJ of heat on the anode. If the anode is tungsten, the specific heat is 0.134 J/g/K. To keep the temperature below 1000 C. in order not to deform or melt the anode, the anode mass needs to be at least 370 gm. An anode of copper coated with a thick layer of gold would only have to be 130 gm. These parameters can be increased by at least 2-3 times without seriously changing the size or footprint of the source. For repeat exposures or for longer exposures, the anode in this system can be actively cooled whereas the rotating anode system has to rely on anode mass for heat storage and inefficient cooling through a slip-ring and slow radiative transfer of heat out of the vacuum vessel. The monochromatic x-ray systems described above can be actively cooled with water.
[0238] According to some embodiments, the primary anode material can be chosen to maximize the fluorescent intensity from the secondary. In the tests to date, the material of the primary has been either tungsten (W) or gold (Au). They emit characteristic K emission lines at 59 keV and 68 keV, respectively. These energies are relatively high compared to the absorption edges of silver (Ag; 25.6 keV) or tin (Sn; 29 keV) thereby making them somewhat less effective in inducing x-ray fluorescence in the Ag or Sn secondary targets. These lines may not even be excited if the primary voltage is lower than 59 keV. In this situation only the Bremsstrahlung induces the fluorescence. Primary material can be chosen with characteristic lines that are much closer in energy to the absorption edges of the secondary, thereby increasing the probability of x-ray fluorescence. For example, elements of barium, lanthanum, cerium, samarium or compounds containing these elements may be used as long as they can be formed into the appropriate shape. All have melting points above 1000 C. If one desires to enhance production of monochromatic lines above 50 ke V in the most efficient way, higher Z elements are needed. For example, depleted uranium may be used (K line=98 keV) to effectively induce x-ray fluorescence in Au (absorption edge=80.7 keV). Operating the primary at 160 kV, the Bremsstrahlung plus characteristic uranium K lines could produce monochromatic Au lines for thorasic/chest imaging, cranial imaging or non-destructive industrial materials analysis.
[0239] For many x-ray imaging applications including mammography, the x-ray detector is an imaging array that integrates the energies of the absorbed photons. All spectroscopic information is lost. If a spectroscopic imager is available for a particular situation, the secondary target could be a composite of multiple materials. Simultaneous spectroscopic imaging could be performed at a minimum of two energies to determine material properties of the sample. Even if an imaging detector with spectral capability were available for use with a broad-band source used in a conventional x-ray mammography system for the purpose of determining the chemical composition of a suspicious lesion, the use of the spectroscopic imager would not reduce the dose to the tissue (or generically the sample) because the broad band source delivers a higher dose to the sample than the monochromatic spectrum.
[0240] Contrast-enhanced mammography using monochromatic x-ray radiation is superior to using the broad band x-ray emission. It can significantly increase the image detail by selectively absorbing the monochromatic X-rays at lower doses. The selective X-ray absorption of a targeted contrast agent would also facilitate highly targeted therapeutic X-ray treatment of breast tumors. In the contrast enhanced digital mammographic imaging conducted to date with broad band x-ray emission from conventional x-ray tubes, users try to take advantage of the increased absorption in the agent, such as iodine, by adjusting the filtering and increasing the electron accelerating voltage to produce sufficient x-ray fluorescence above the 33 keV K absorption edge of iodine. FIG. 72 shows the mass absorption curves for iodine as a function of x-ray energy. The discontinuous jumps are the L and K absorption edges. The contrast media will offer greater absorption properties if the broad band spectra from conventional sources span an energy range that incorporates these edges. As a result, detectability should improve.
[0241] Monochromatic radiation used in the mammographic system discussed here offers many more options for contrast-enhanced imaging. Ordinarily, one can select a fluorescent target to produce a monochromatic energy that just exceeds the iodine absorption edge. In this sense, the monochromatic x-ray emission from the tube is tuned to the absorption characteristics of the contrast agent. To further improve the sensitivity, two separate fluorescent secondary targets may be chosen that will emit monochromatic X-rays with energies that are below and above the absorption edge of the contrast agent. The difference in absorption obtained above and below the edge can further improve the image contrast by effectively removing effects from neighboring tissue where the contrast agent did not accumulate. Note that the majority of x-ray imaging detectors currently used in mammography do not have the energy resolution to discriminate between these two energies if they irradiate the detector simultaneously; these two measurements must be done separately with two different fluorescent targets in succession. This is surely a possibility and is incorporated in our system.
[0242] Since the contrast agent enhances the x-ray absorption relative to the surrounding tissue, it is not necessary to select a monochromatic energy above the K edge to maximize absorption. For example, FIG. 72 shows that the absorption coefficient for the Pd K 21.175 keV energy, which is below the K edge, is comparable to the absorption coefficient of the Nd K 37.36 keV energy which is above the K edge. As long as the atoms of the contrast agent are sufficiently heavier (atomic number, Z>45) than the those in the surrounding tissue (C, O, N, P, S; Z<10 and trace amounts of Fe, Ni, Zn, etc., Z<30), the monochromatic x-ray technique increases the potential choices for contrast agents in the future. The secondary targets of Pd, Ag and Sn are perfect options for this application. Using monochromatic energies below the absorption edge of iodine, for example, takes better advantage of the quantum absorption efficiency of a typical mammographic imaging detector. The absorption at 37 keV (above the iodine edge) is about 2 times lower than at 22 keV (below the edge). The lower energy may also prove to have better detectability in the surrounding tissue simultaneously. FIG. 73 shows a linear set of 3 drops of Oxilan 350, an approved iodine contrast agent manufactured by Guerbet superimposed on the the ACR phantom. The amount of iodine in each of the drops 1 mg iodine.
[0243] As discussed above, increasing the input power on the primary target (anode) of a monochromatic x-ray source allows higher intensity production of monochromatic x-rays (characteristic x-rays emitted by the secondary target) by the x-ray source. Increasing x-ray intensity allows shorter exposures which reduce motion artifacts and increase patient comfort. Increased x-ray intensity can additionally be used to provide increased SNR to enable the detection of less obvious features. Though straightforward in principle, providing a high power monochromatic x-ray source presents significant challenges that have thus far prevented their implementation, including problems of heat dissipation. The term high power is used herein generally to refer to an input power above 10 KW, which input power is the product of the voltage potential between the cathode and the anode and the flow of electrons (the current) between the cathode and anode. These electrons originate from the cathode via thermionic emission, the process by which electrons are emitted from a wire or surface that is heated to a high temperature. For example, a cathode filament (e.g., a tungsten wire) may be heated ohmically by a power supply to cause the cathode filament to emit electrons that are then accelerated toward to the anode (primary target) by the applied voltage potential between the cathode and the anode. An 80 kV potential between the cathode and the anode and an 150 mA electron beam emitted by the cathode provides 12 kW of input power to the primary target, as one example.
[0244] Applicant has designed and developed a high-power monochromatic x-ray system that addresses heat dissipation challenges arising from higher power operation, thus providing a monochromatic x-ray source that emits x-rays at correspondingly higher intensity. The increased intensity x-ray emission, in turn, allows x-ray imaging procedures (e.g., breast imaging) to be performed with reduced exposure times, reduced x-ray dose and/or increased SNR. One aspect of the heat dissipation problem associated with high-power operation involves heating of the anode target resulting from the high-intensity bombardment of high-energy electrons on the target. As mentioned above, conventional broadband x-ray sources configured for high-power operation (e.g., above 10 kW) typically address anode heating by using a rotating anode. By continuously rotating the anode at high speeds (e.g., 10,000 RPM) the surface of the anode target that is bombarded by electrons emitted from the cathode continuously changes, thus eliminating sustained bombardment and heating of any one area of the anode. In addition to being relatively complex and expensive components, rotating anode systems are generally not suitable for monochromatic x-rays sources for a number of reasons. For example, broadband x-ray sources have a single stage of x-ray generation, i.e., electrons emitted by the energized cathode bombard the anode target to produce broadband x-rays (Bremsstrahlung) that are emitted from the source to irradiate the subject being imaged. As a result, the resolution of images obtained using conventional broadband images is related to the spot size of the region of the anode target at which electrons impinge. Broadband x-ray sources thus conventionally employ a cathode at ground potential and an anode at a high positive voltage such that the electron beam is drawn to and strikes a relatively small region of the anode target, thereby allowing a spinning anode to continuously vary the surface of the anode target within the impact region of electron bombardment at any given point in time.
[0245] By contrast, the resolution of images acquired using a monochromatic x-ray source is related to the size of the secondary target that produces the fluorescent (monochromatic) x-rays emitted by the source and the intensity of the emitted monochromatic x-rays depends, in part, on the intensity of the broadband x-rays incident on the secondary target, as discussed in the foregoing. It is therefore, in general, preferable to maximize the surface of the primary target of a monochromatic x-ray source that is simultaneously bombarded with electrons (e.g., as much of the interior surface of the conical primary target discussed above and in further detail below) to maximize the broadband x-ray flux capable of being absorbed by the secondary target to produce monochromatic x-rays. This configuration intrinsically distributes the heat over the large surface of the anode, thereby reducing the power density. This allows the primary to be cooled without rotation.
[0246] According to some embodiments, the cathode of an x-ray source is energized at a high negative voltage and a stationary anode/primary target is maintained at ground potential. To cool the primary target during high-power operation, Applicant has developed an integrated cooling system configured to cool the primary target of a monochromatic x-ray source. In the exemplary embodiments illustrated in FIGS. 74-79 discussed below, the primary target is coupled to a heat sink component comprising a conduit through which coolant (e.g., chilled water) is circulated. The heat sink conducts heat generated by electron bombardment of the primary target away from the primary target and transfers the heat to the circulating coolant. According to some preferred embodiments, the primary target is cooled by circulating water through the integrated cooling system, however, a other coolants (e.g., a brine with a lower freezing point than water) can be used to achieve a desired heat transfer capacity for the cooling system.
[0247] Another problem associated with high-power operation of a monochromatic x-ray source involves heating of the x-ray window that provides the interface between the vacuum chamber (e.g., vacuum tube) and the secondary target through which broadband x-rays pass to irradiate the secondary target (see e.g., the x-ray windows of the exemplary monochromatic x-ray sources described in connection with FIGS. 11A-11C, 12, 24A-24B, 27-28, 45B, 64-65 and 66C), which was previously understood to place a limit on the power level that could be employed in such a configuration. While the electron optics design discussed in the foregoing (e.g., the electron optics with concentric guides illustrated in FIG. 11B) are effective in minimizing electrons emitted from the cathode that are directly incident on the x-ray interface (see e.g., FIGS. 24A-24B and 25-28), back scattered electrons from the primary target (i.e., electrons incident on the primary target that are not absorbed but are instead scattered off the primary target) will still strike the x-ray interface and cause undesirable heating of the x-ray window. As just mentioned, the conventional understanding was that heating of the x-ray window from back scattered electrons would limit the power level that could be used in a monochromatic x-ray source to approximately 6 kW without damaging (e.g., melting) the x-ray window and rendering the x-ray source inoperable. Applicant recognized that this previously unresolved problem could be addressed by providing an electron shield over the x-ray window to absorb back scattered electrons to prevent such electrons from bombarding the x-ray window, thus allowing higher-power operation of a monochromatic x-ray source of this configuration than was previously considered feasible.
[0248] Applicant has appreciated that an effective electron shield should be capable of absorbing back scattered electrons to prevent the electrons from striking the x-ray window while being suitably transmissive to broadband x-rays produced by the primary target to avoid interfering with efficient production of fluorescent x-rays by the secondary target in response to broadband x-rays impinging thereon. To that end, Applicant has identified a number of desirable properties of an effective electron shield, including sufficiently high thermal conductivity for dissipating the heat of absorbed electrons, low Z-number to allow highly efficient passage of broadband x-rays capable of producing monochromatic x-ray radiation via fluorescence, sufficiently high melting (or sublimation) point, good electrical conductivity to avoid charging of the electron shield, and suitably cost effective. Applicant recognized that graphite beneficially exhibits these properties. Thus, according to some embodiments, an electron shield formed at least in part from graphite is provided over the x-ray window to absorb back scattered electrons while allowing transmission of broadband x-rays to pass through to impinge on the secondary target.
[0249] Other materials may be used to form an electron shield according to some embodiments (e.g., graphene, aluminum, etc.), as the aspects of an electron shield implementation is not limited to the use of graphite or any specific material. Furthermore, an electron shield need not exhibit (nor optimally exhibit) each of the above-mentioned properties, as a given implementation may favor one or more of these properties over others, or may not require an electron shield that exhibits each of these properties. According to some embodiments, an electron shield formed from a composite of materials may be employed to take advantage of the properties of different materials (e.g., silicon carbide). According to some embodiments, an electron shield is beneficially integrated with the anode cooling system. For example, an electron shield configured to cover the x-ray window may be coupled to the heat sink such that heat generated from the absorption of back scattered electrons is dissipated by the heat sink and/or transferred to the circulating coolant. Exemplary electron shield implementations in accordance with some embodiments are described in further detail below. Such an integrated cooling system provides a relatively simple and cost-effective way to cool the primary target during high-power operation. As illustrated by the heating and cooling curves illustrated in FIGS. 81A-81D and 83 discussed below, the effectiveness of the cooling system demonstrates the scalability of the exemplary high-power x-ray source configuration illustrated in FIGS. 74-80 to much higher power operation, including the feasibility of up to 100-kW operation of the x-ray source.
[0250] FIGS. 74A and 74B illustrate cross-sectional views of a monochromatic x-ray source configured for high-power operation, in accordance with some embodiments. X-ray source 7400 comprises a housing 7405 (e.g., an x-ray tube) having a chamber 7415, held under vacuum, that contains an electron source 8500 comprising a cathode 8510 (e.g., a toroidal cathode) operatively coupled to an external power source (not shown in FIG. 74) via interface 8590 to energize the cathode, and a stationary anode 7500 that houses primary target 7510 and forms the top portion of a heat sink component 7600 that dissipates heat generated when electrons emitted by cathode 8510 impact the primary target, as discussed in further detail below. Unlike conventional high-power broadband x-ray sources that apply a voltage to the anode to accelerate electrons emitted by the cathode via thermionic emission to the anode to form the electron beam, a high negative voltage is applied to cathode 8510 while anode 7500 is held at a more positive reference potential (e.g., ground) so that electrons emitted from cathode 8510, when energized (heated), are accelerated towards primary target 7510 to strike the target's inner surface to produce broadband x-rays. Because anode 1500 is not raised to a high voltage potential, the primary target can be water-cooled without requiring the implementation of relatively complex and expensive de-ionization processes and infrastructure.
[0251] In the exemplary anode 7500 illustrated in FIGS. 74A and 74B, primary target 7510 is positioned within a recess 7520a formed within an upper heat sink portion 7520 configured to conduct heat generated from electron bombardment of the primary target away from the primary target and transfer heat to coolant circulating through the heat sink. To that end, upper heat sink portion 7520 may have a semi-circular trench 7520b formed therein that travels annularly around the upper sink component and that, together with a corresponding semi-circular trench 7620b formed within lower heat sink portion 7620, provides a conduit through which coolant (e.g., water) can be circulated to cool primary target 7510. An exemplary conduit for circulating coolant through the heat sink is discussed in further detail below in connection with FIGS. 76A and 75B. Coolant may be introduced via an inlet tube 8085a (see also FIG. 80A) connected to an inlet provided through the lower heat sink portion 7620 and connected to trench 7620b, circulated through the conduit and removed through an outlet formed through lower heat sink portion 7620 via an outlet tube 8085b, as discussed in further detail in connection with FIGS. 76A and 76B. In this manner, the primary target 7510 of x-ray source 7400 can be cooled in a relatively simple and inexpensive way by integrating the cooling system into the heat sink, a portion of which may form part of the anode. In some embodiments, the coolant circulated through the anode is water that has been chilled to a desired temperature (e.g., via refrigeration such as a chiller and re-circulated, or via a facilities cold water source). In some embodiments, a coolant with a lower freezing point than water may be used to increase the heat transfer capacity of the cooling system. In this way, the heat transfer capacity of the cooling system can be adapted to meet the heat dissipation needs of a given x-ray source implementation.
[0252] In exemplary x-ray source 7400, primary target 7510 has a passage formed through its lower end that is sized to accommodate an electron shield 7750 and an x-ray window 7830 within which a secondary target is positioned. FIG. 74A illustrates the cross-sectional view without a secondary target and FIG. 74B illustrates the cross-sectional view in which a carrier 7940 holding a secondary target 7920 is inserted such that secondary target 7920 is positioned within x-ray window 7930. Removeable carrier 7940 housing the secondary target may be inserted via recess 7620 formed in lower heat sink portion 7620 and fixed into place by inserting collimator 7960 into recess 7620a, as shown in FIG. 74B, and securing the collimator 7960 to the lower heat sink portion 7620 (e.g., via screws). As discussed in further detail in connection with the exemplary components illustrated in FIGS. 75-77, according to some embodiments, recess 7520b formed within upper heat sink portion 7520 may include a further recessed portion at the lower end having a rim configured to support and thermally coupled with electron shield 7750 and a passage formed through upper heat sink portion 7520 to which x-ray window 7830 is attached and through which a secondary target may be inserted into position within the x-ray window. As discussed above, electron shield 7750 is configured to absorb electrons that are back scattered from the primary target (or electrons that would otherwise strike x-ray window 7830) to prevent electron bombardment from overheating the x-ray window and from producing unwanted Bremsstrahlung radiation that could contaminate a desired monochromatic spectrum (i.e., fluorescent x-rays emitted at one or more characteristic energy levels of the secondary target). Thermal coupling between electron shield 7750 and upper heat sink portion 7520 allows heat generated by electrons striking electron shield 7750 to be conducted from the shield to the heat sink and transferred to the coolant circulating through the heat sink, thus making use of the same integrated cooling system implemented to cool the primary target. Exemplary electron shield implementations are discussed in connection with FIGS. 77A-77E below.
[0253] FIG. 74C illustrates a perspective view showing this exemplary configuration with a primary target 7510 positioned within the recess formed in upper heat sink portion 7520, electron shield 7750 seated on the rim of the further recess positioned through the passage formed through the lower portion of the primary target 7510, and x-ray window 7830 positioned through the passage formed through upper heat sink portion 7520 and the passage through the primary target. As discussed above, x-ray window 7830 is configured to provide the interface between the vacuum chamber 7415 and atmosphere when chamber 7415 is vacuum pumped. Thus, x-ray window 7830 may be hermetically joined to upper heat sink portion 7520, for example, by brazing x-ray window 7830 to inner walls of the passage through the upper heat sink portion, as discussed in further detail in connection with FIGS. 78A-7E. FIG. 74C also illustrates secondary target 7920 positioned within the x-ray window 7830 by means of inserting removeable carrier 7940 (e.g., any of the secondary target and carrier configurations discussed in the foregoing) via recess 7620a formed in the lower heat sink portion 7620 (as illustrated in FIG. 74A) with a corresponding passage formed through the top side of the lower heat sink portion 7620 that aligns with the passage formed through the bottom side of the upper heat sink portion 7520, as shown in FIG. 74A and as discussed in further detail in connection with FIGS. 79A-79D. As illustrated in FIGS. 74A and 74B, recess 7620a formed within lower heat sink portion 7620 is configured to accommodate collimator 7960 and the end portion of carrier 7940 as illustrated in FIGS. 74B and 74C. In embodiments that do not employ a carrier or that utilize a carrier that fits completely within the x-ray window, collimator 7960 may be sized to completely fill recess 7620a. Exemplary collimator implementations are discussed in further detail in connection with FIGS. 79A-D below. As shown in the exemplary configurations illustrated in FIGS. 74A-74C, an x-ray window may be positioned between the secondary target and the primary target, and an electron shield may be positioned between the x-ray window and the primary target.
[0254] Exemplary implementations of the above-described components of x-ray source 7400 and illustrative examples of how the components may be integrated together in accordance with some embodiments are further described below in connection with FIGS. 75-79. FIGS. 75A-75C illustrate views of an exemplary primary target 7510, in accordance with some embodiments. FIG. 75D illustrates a view of an exemplary anode 7500 showing the primary target 7510 separated from the upper heat sink portion 7520 and FIG. 75E illustrates a view in which the primary target 7510 is positioned within recess 7520a of the upper heat sink portion 7520, in accordance with some embodiments. As illustrated in FIGS. 75A-75E, primary target 7510 may have a conical shape with an inner surface 7511 to which electrons emitted by the cathode are accelerated to impinge on the primary target to generate broadband x-rays. Primary target 7510 may also comprise a passage 7510e through which an electron shield, x-ray window and secondary target are allowed to pass to position these components internal to inner surface 7511 (e.g., as shown by the exemplary configuration illustrated in FIGS. 74A and 74B discussed above). Exemplary primary target 7510 may also include a brim or lip 7512 and outer surface 7513 (see FIG. 75B) adapted to cooperate with corresponding features of recess 7520a of upper heat sink portion 7520 to facilitate attachment to and thermal coupling between the primary target 7510 and the upper heat sink portion 7520, as shown in FIGS. 75D-E discussed below.
[0255] Primary target 7510 may comprise any material suitable for producing x-rays in response to electrons emitted from the cathode incident thereon (e.g., molybdenum, tantalum, tungsten, gold, etc.) or may comprise a composite of materials (e.g., tungsten plated with gold, a tungsten alloy, etc), as the aspects are not limited to any particular choice of primary target material or materials. According to some embodiments, primary target 7510 is formed from tungsten, thus providing a high atomic number (Z) target that efficiently converts the energy in incident electrons to broadband x-rays and that has a high melting point and that is durable. As discussed above, x-rays produced from electron bombardment of the primary target will include characteristic x-rays of the material(s) used for the primary target (i.e., x-rays at energies corresponding to the K, L and M shells of the material) and bremsstrahlung x-rays resulting from the deceleration of the electrons by the primary target (scc e.g., FIG. 5 for a molybdenum target). The material or materials used to form primary target 7510 may be selected so as to generate characteristic x-rays at energy levels that facilitate the production of the characteristic x-rays emitted by the secondary target (i.e., energy levels having increased probability of being absorbed by the secondary target and causing release of fluorescent x-rays at the characteristic energy levels of the secondary target).
[0256] As illustrated in FIG. 75D, recess 7520a formed in top side of upper heat sink portion 7520 includes a rim or ledge 7522 corresponding to brim 7512 of the primary target so that when the primary target is positioned within recess 7520a, brim 7512 sits on and against rim 7522 and outer surface 7513 of the primary target (best seen in FIG. 75B) inner surface 7523 of recess 7520a to facilitate thermal coupling. In this way, heat generated from the bombardment of the primary target by electrons emitted by the cathode can be dissipated by upper heat sink portion 7520. To this end, upper heat sink portion 7520 may be formed of a material that is suitably heat conductive (e.g., preferably copper, but other materials such as aluminum can be used) to efficiently conduct heat away from the primary target to prevent overheating. It is also advantageous for the heat sink to have high heat capacity minimize its temperature excursions. As discussed further below in connection with FIGS. 76A and 76B, heat from the primary target absorbed by the upper heat sink component can also be transferred to coolant circulating through the heat sink component 760 when the upper and lower heat sink portions are joined together, thus increasing the heat transfer capacity of the exemplary cooling system. Primary target 7510 may be joined to upper heat sink portion 7520, for example, by a brazing process to facilitate retaining good thermal coupling between the primary target and the heat sink.
[0257] FIG. 75E illustrates anode 7500 with primary target 7510 positioned within recess 7520a formed in the top side of upper heat sink portion 7520. As discussed above in connection with the exemplary x-ray source 7400 illustrated in FIGS. 74A and 74B, an electron shield may be positioned between the upper heat sink portion 7520 and primary target 7510 that passes through opening 7510 to cover an x-ray window attached to passage 7520e formed in the bottom of recess 7520e. FIG. 75E illustrates the anode without the electron shield and x-ray window in place to illustrate the coupling between the primary target and the heat sink and to show passage 7520e formed through the upper heat sink portion that accommodates the x-ray window into which a secondary target (preferably accommodated within a carrier device as discussed in the foregoing) can be removably inserted to position the secondary target within the conical interior space of primary target 7510. An exemplary electron shield and x-ray window implementation and illustrative examples of integrating the components together are discussed below in connection with FIGS. 77A-D and 78A-E.
[0258] FIGS. 76A and 76B illustrate an exemplary heat sink component 7600 formed by upper and lower heat sink portions 7520 and 7620 via which an integrated cooling system can be formed in accordance with some embodiments. FIG. 76A illustrates views of the bottom side of upper heat sink portion 7520 (the top side of which is illustrated in FIGS. 75D and 75E) and the top side of lower heat sink portion 7620 and FIG. 76B illustrates views of the bottom side of upper heat sink portion 7520 and the bottom side of lower heat sink portion 7620 to show exemplary features of an exemplary integrated cooling system. As illustrated in FIG. 76A, a semi-circular trench 7520b may be formed in the bottom side of upper heat sink portion 7520 corresponding to a cooperating semi-circular trench 7620b formed in the top side of lower sink component 7620 that together form a conduit for coolant when the upper heat sink portion 7520 and lower heat sink portion 7620 are joined together. In the exemplary embodiment illustrated in FIGS. 76A and 76B, trench 7520b forms an annular ring with terminal ends 7520c and 7520d that align with inlet passage 7620c and outlet passage 7620d, respectively, that are formed at the terminal ends of trench 7620b.
[0259] As can be seen in the view of the bottom side of the lower heat sink portion 7620 illustrated in FIG. 76B, inlet passage 7620c and outlet passage 7620d are formed through the lower heat sink portion 7620 so that inlet and outlet tubes can be connected to the heat sink (see e.g., FIG. 79D). Coolant can thus be introduced to the heat sink via an inlet tube connected to inlet 7620c, circulated through the conduit formed by trenches 7520b and 7620b when the upper and lower heat sink portions are joined together to form heat sink component 7600, and output via an outlet tube connected to outlet 7620d. In this way, an integrated cooling system can be implemented in a compact and efficient manner to provide increased heat transfer capacity that facilitates cooling of the primary target during high-power operation of the monochromatic x-ray source. As discussed above and in further detail below in connection with FIGS. 77A-77F, the integrated cooling system can also be used to dissipate heat generated by back scattered electrons striking an electron shield implemented in accordance with some embodiments.
[0260] According to some embodiments, the x-ray source is water-cooled. However, a coolant with a lower freezing point (e.g., a brine) can be used to further increase the heat transfer capacity of the cooling system. As such, the integrated cooling system developed by Applicant provides a cooling system that can be adapted to meet the cooling needs of different implementations, power levels and/or exposure protocols. While the above-described exemplary cooling system implements the coolant circulating conduit via cooperating trenches in both the upper and lower heat sink portions of the heat sink component, the conduit may be implemented in other ways. For example, the conduit may be formed in the upper heat sink portion that terminates in inlet and outlet passages that connect to corresponding inlet and outlet passages formed through the lower heat sink portion. As another alternative embodiment, the conduit (whether formed as cooperating trenches or otherwise) may be formed in a spiral such that coolant is circulating through multiple annular turns before being removed via the outlet. FIGS. 76A and 76B also illustrate exemplary passage 7520e formed through upper heat sink portion 7520 to which an x-ray window may be attached and illustrates exemplary passage 7620e formed through lower heat sink portion 7620 via which a secondary target may be inserted and positioned within the x-ray window via passage 7520e and that accommodates a portion of a collimator, in accordance with some embodiments.
[0261] As discussed above, Applicant recognized that implementing an electron shield facilitates operating a monochromatic x-ray source at power levels above what was previously considered feasible for implementations that utilize an x-ray window. FIGS. 77A-77D illustrate views of an exemplary electron shield 7750 and FIGS. 77E-77F illustrate the manner in which an electron shield can be positioned within the anode of the x-ray source, in accordance with some embodiments. As illustrated in FIGS. 74A and 74B, an exemplary electron shield 7750 may be dimensioned to accommodate an x-ray window 7830 within the interior space of the shield (see e.g., interior space 7750a labeled in FIG. 77C) to block electrons back scattered from the primary target (and stray electrons from the cathode that would otherwise strike the x-ray window). As illustrated in FIGS. 77A-77C, exemplary electron shield 7750 may comprise top and side portions 7752a and 7752b to provide a cover 7752 over an x-ray window configured to absorb electrons while passing broadband x-rays emitted by the primary target. According to some embodiments, the electron shield may have a thickness of approximately 0.75 mm, but the electron shield may be made thicker or thinner to suit the needs of a particular implementation. Cover 7752 may be formed as a single contiguous piece of a selected material (e.g., a single piece machined from the bulk material selected) or may be formed by separate top and side portions that are attached together (and which may be formed from the same or different materials). Cover 7752 may alternatively be formed from laminated layers of the same or different materials.
[0262] According to some embodiments, electron shield 7750 also includes a brim 7754 to facilitate positioning and securing the electron shield to the anode of the x-ray source, as shown in FIGS. 77E and 77F discussed below. Brim 7754 may be formed from the same material as cover 7752 (e.g., the entirety of the electron shield may be machined as a single piece from the same bulk material) or may be formed from a different material. Brim 7754 and side portion 7752b may include openings 7750c that allow air between the electron shield and the x-ray window to escape when the x-ray source is vacuum pumped, thus avoiding trapping air within the vacuum chamber of the system. As illustrated in FIGS. 77E, brim 7754 may be dimensioned to fit into a further recess formed in the bottom of recess 7520a formed in upper heat sink portion 7520 so that when electron shield 7750 is positioned in recess 7520a, brim 7754 rests on rim 7524 formed at the bottom of the recess. As discussed further in connection with FIGS. 78A-78E, x-ray window 7830 may be positioned through and attached to passage 7520e so that when electron shield 7750 is positioned within recess 7520a in the above-discussed manner, the electron shield covers the portion of the x-ray window that extends into and above recess 7520a (e.g., as illustrated in FIGS. 74A and 75B). The x-ray window is not illustrated in FIGS. 77E and 77F to better illustrate the positioning of the electron shield on the rim formed at the bottom of the recess. Once the electron shield is positioned, primary target 7510 may be placed within recess 7520a in the manner discussed above in connection with FIGS. 75D and 75E. Specifically, when primary target is positioned within recess 7520a, electron shield 7750 passes through opening 7510e in the primary target such that brim 7754 of the electron shield is sandwiched between rim 7524 of upper heat sink portion 7520 and primary target 7510. FIG. 77F illustrates anode 1500 with exemplary electron shield 7750 (under which the x-ray window is disposed) and primary target 7510 positioned within the recess of the upper heat sink portion 7620. Primary target may then be joined to the upper heat sink portion 7520, e.g., via a brazing process, thus securing both the primary target and the electron shield into place.
[0263] The above-described configuration provides several benefits in implementing an x-ray source in addition to shielding the x-ray window from back scattered electrons. For example, providing an electron shield with a brim provides a surface in contact with the upper heat sink portion 7520 so that heat generated when electrons strike the shield can be conducted to the heat sink and transferred to circulating coolant. Thus, the integrated cooling system can be employed to cool both the primary target and the electron shield. Additionally, positioning the brim within a cooperating recess within the heat sink allows the primary target to sit flush within the recess to maintain a large surface area of contact between the primary target and the heat sink to efficiently transfer heat from the primary target to the heat sink. Implementing an electron shield with a brim further allows the electron shieled to be secured to the heat sink outside the interior volume of the primary target to avoid potentially interfering with or otherwise negatively impacting the production of broadband x-rays.
[0264] As discussed above, Applicant recognized that an electron shield formed from graphite provides a number of desirable properties, including a high thermal conductivity (e.g., approximately 2000 watts per meter-Kelvin (W/(m.Math.K) for highly oriented graphite and up to approximately 4000 W/m.Math.K for highly crystalline stress-annealed graphite in the in-plane (basal) direction), a low Z-number (graphite is formed of carbon which has an atomic number of 6) to allow passage of the broadband x-rays with energies capable of producing fluorescent x-ray radiation in response to being absorbed by the secondary target, a high melting/sublimation point (graphite sublimes, meaning it transitions from a solid to a gaseous state, at approximately 3600 C. or more), and good electrical conductivity so as to avoid storing charge in the electron shield. Graphite is also relatively cost effective and is suitable for high-precision machining. Diamond likewise provides similar desirable properties, but is not as cost effective as graphite, nor is it as good of an electrical conductor. Other materials with low Z-numbers and high melting points such as boron and boron-based compounds (e.g., beryllium oxide, boron nitride that exhibits a relatively high thermal conductivity) may also be used to provide a suitable electron shield according to some embodiments, but they also have poorer electrical conductivity properties. Silicon-carbide on the other hand has similarly good thermal properties and has very good electrical conductivity. Higher Z-number materials with high melting points (e.g., Rhenium) may also be used and may be particularly suited for implementations using a secondary target with a sufficiently high absorption edge. In such an embodiment, the broad band Bremsstrahlung radiation would have to extend to very high energies (>100 keV). In this respect, while some preferred embodiments utilize graphite, aspects related to implementing an electron shield are not limited to any particular material or materials.
[0265] FIGS. 78A-78C illustrate different views of an exemplary x-ray window 7830 and FIGS. 78D-78E illustrate how the x-ray window can be positioned within the anode of the x-ray source, in accordance with some embodiments. As illustrated in FIGS. 78A-C, exemplary x-ray window 7830 may be formed by a cylindrical portion 7832 and a tapered or beveled portion 7836 that provide a receptacle in which a secondary target can be positioned via insertion through opening 7830c. As discussed in the foregoing, x-ray window may be formed from beryllium or may be formed using other materials that are transmissive to a suitably range of broadband x-rays. As discussed above, x-ray window may provide the interface between the vacuum chamber and atmosphere. In such embodiments, x-ray window may be hermetically attached to the upper heat sink portion 7520, as illustrated in FIGS. 78D-78E. To facilitate attaching x-ray window 7830 to the heat sink, the side wall 7526 of passage 7520e formed through the upper heat sink portion 7520 may be tapered or beveled to cooperate with corresponding tapered portion 7836 of x-ray window 7830 as illustrated in FIG. 78D. Thus, when x-ray window 7830 is positioned in the bottom of recess 7520a, cylindrical portion 7836 sits on top passage 7520e and tapered portion 7836 fits into passage 7520c and contacts the cooperating tapered side walls of passage 7520e. The contacting tapered portions may then be hermetically attached, for example, using a brazing process to seal the interface between vacuum and atmospheric pressure when the vacuum chamber is pumped to avoid leakage. Once the x-ray window 7830 is attached to upper heat sink portion 7520 as shown in FIG. 78E, the electron shield may be positioned within recess 7520a followed by the primary target as discussed above in connection with FIGS. 77E-F. The upper and lower heat sink components 7520 and 7620 may then be attached, for example, using a brazing process to provide a heat sink component with an internal conduit for circulating coolant (e.g., as discussed above in connection with the exemplary heat sink component 7600 illustrated in FIGS. 76A-76B).
[0266] FIGS. 79A-79C illustrate views of an exemplary removeable collimator 7960, FIG. 79D illustrates the manner in which a secondary target can be removably deployed within the x-ray window of the x-ray source via the bottom side of the lower heat sink portion by detaching and re-attaching the collimator to the lower heat sink portion, and FIG. 80A illustrates a view of the collimator positioned within the lower heat sink portion for operation, in accordance with some embodiments. As illustrated in FIGS. 79A-79C, exemplary collimator 7960 is composed of a plurality of tiered cylindrical portions 7962, 7964 and 7966 sized to cooperate with corresponding features of recess 7620b formed in the bottom side of lower heat sink portion 7620, as illustrated in FIG. 79D. Each of the cylindrical portions comprise one or more stacked annular discs formed of a blocking material (shown in crosshatching) capable of absorbing x-ray radiation and arranged so that the annulus of each disc align to form a passage 7960e through the center of the collimator to allow passage of monochromatic x-rays produced by the secondary target. For example, cylindrical portion 7966 comprises three stacked discs 7966a-7966c and each of cylindrical portions 7964 and 7964 comprise discs 7964a and 7962a, respectively, in exemplary collimator 7960. The stack of annular discs (e.g., lead discs, or discs formed of another high-Z material) are secured together within a housing 7961 comprising a bottom plate 7961b that can be screwed into a top portion 7961. An opening 7961e in bottom plate 7961b of the housing aligns with passage 7960e to provide the aperture of the monochromatic x-ray source.
[0267] The side walls of the annulus of each disc may be tapered to facilitate the capture of obliquely propagating x-rays and to optimally absorb x-rays that are scattered by another discuss and/or any x-rays that may be generated by broadband x-rays that find their way into the passage of the collimator and that are of high enough energy to cause the blocking material to produce fluorescent x-ray radiation. Thus, collimator 7960 is configured to allow passage of desired monochromatic x-rays within a desired view angle (e.g., 30) and to block other x-rays such that the x-ray source emits a cone beam of x-rays that can be narrowed as desired, taking into consideration that, in general, the narrower the cone beam, the lower the exiting x-ray intensity will be due to the increased number of x-rays that get absorbed by the collimator. A narrower cone beam also has a smaller field of view in the image plane. Collimator 7960 is also configured to block broadband x-rays propagating externally to the collimator (e.g., broadband x-rays emitted from primary target in directions away from the secondary target that may pass through the heat sink component) to prevent undesirable broadband x-rays from being emitted by the x-ray source. Thus, collimator 7960 facilitates producing a focused x-ray beam with high monochromaticity (a high proportion of fluorescent x-rays at one or more of the characteristic energy levels (e.g., K, K, etc.) of the exemplary target relative to broadband x-rays (Bremsstralung) that undesirable increase dose and degrade image quality. Exemplary collimator 7960 also includes flanges 7963a and 7963b with screw holes for accommodating screws 7965a and 7965b to attach the collimator to the lower heat sink portion, as illustrated in FIGS. 79D and 79E.
[0268] FIG. 79D illustrates the lower heat sink portion 7620 viewed from the bottom side (i.e., the view also illustrated in FIG. 76B discussed above), an exemplary carrier 7940 that holds a secondary target 7920, and collimator 7960 discussed in connection with FIGS. 79A-C. As shown, recess 7620a formed in the bottom side of lower heat sink portion 7620 is tiered in correspondence with the tiered cylindrical portions of the collimator 7960. Specifically, when collimator 7960 is inserted into recess 7620a, the top surface of cylindrical portion 7962 rests against rim 7622, the top surface of cylindrical portion 7964 rests against rim 7624 and cylindrical portion 7966 fits into passage 7620c. Recess 7620a also includes openings 7623a and 7623b to accommodate flanges 7963a and 7963b, respectively. Screw holes (not shown) are also provided within openings 7623a and 7623b so that the collimator can be screwed securely into the lower heat sink portion via screws 7965a and 7965b.
[0269] Prior to attaching collimator 7960 to the heat sink, a selected secondary target 7920 can be positioned with the x-ray window 7830 by inserting carrier 7940 into passage 7620e. Carrier 7940 may be configured in any of the ways disclosed in the foregoing. For example, carrier 7940 may comprise a cylindrical transmissive portion 7942 adapted to accommodate secondary target 7920 and blocking component 7944 composed a cylindrical blocking portion and an annular blocking portion 7944b having a larger diameter than the cylindrical transmissive and block portions. As discussed in the foregoing, cylindrical portions 7942 and 7944a may be sized such that a portion of the secondary target extends into cylindrical blocking portion 7944b when the secondary target is positioned within the transmissive portion 7942 as illustrated (e.g., any of the exemplary carriers illustrated in FIGS. 11A-11B, 12, 17A-B, 45B and 64-65) or may be sized such that the secondary target is contained entirely within the transmissive portion 7942 (e.g., any of the exemplary carriers illustrated in FIGS. 13A-13B and 66A-66B). In FIG. 79D, exemplary secondary target 7920 is illustrated generically as a cone, but it will be appreciated that any of the secondary targets described herein may be employed, including a solid target (e.g., any of the solid targets illustrated in FIGS. 11A-11C, 12, 13A-C and 17A-C) or any of the secondary targets formed by thin layers of material (e.g., any of the exemplary secondary targets illustrated in FIGS. 42, 45, 48-61, 63-66 and 74B).
[0270] As discussed above in connection with FIG. 76A showing the top side of lower heat sink 7620 and the bottom side of upper heat sink portion 7520, passage 7520e through the upper heat sink component 7520 is smaller than passage 7620e through the lower heat sink portion 7620. When carrier 7940 is inserted into passage 7620e, passage 7620e is large enough to accommodate annular blocking portion 7944b, but passage 7520e is large enough to accommodate cylindrical portions 7942 and 7944a, but not annular blocking portion 7944b. Thus, annular blocking portion 7944b will be stopped at the bottom side of the upper heat sink portion 7520 while the cylindrical portions 7942 and 7944a pass into passage 7520e and x-ray window attached therein such that the cylindrical transmissive portion 7942 and the secondary target housed therein are positioned within x-ray window 7830 covered by electron shield 7750 (e.g., like the configuration illustrated in FIG. 74B). Screwing collimator 7960 into the bottom of the heat sink fixes carrier 7940 in place. If a different secondary target is desired, collimator 7960 can be unscrewed from the heat sink, carrier 7940 removed from the x-ray source, and a different secondary target placed into carrier 7940 and re-inserted into the x-ray source. FIG. 80A illustrates a view of an exemplary x-ray source (e.g., with the internal configuration of components as illustrated in FIGS. 74A-74C) looking into the aperture of the x-ray with the collimator 7960 screwed into the heat sink and inlet and outlet tubes 8085a and 8085b attached to inlet passage 7620c and outlet passage 7620d of the heat sink component, respectively, to circulate coolant through the heat sink transfer heat out of the x-ray source.
[0271] FIG. 80B illustrates a view showing the power interface 8590, which may be a mini-75 power connection for connecting a power cable between a power supply and the power electronics for the cathode of the electron source of the x-ray source (cathode 8510 of electron source 8500 of x-ray source 7400 illustrated in FIGS. 74A and 74B). To demonstrate the efficacy of the integrated cooling system discussed in the foregoing in dissipating heat during high-power operation of the x-ray source, a power supply capable of delivering 12 kW of input power to the electron source. As the heating and cooling curves illustrated in FIGS. 81A-81C calculated for high-power operation of the x-ray source configured described herein and the heating and cooling curves illustrated in FIG. 83 that were measured during high-power operation a prototype x-ray source implementing the above-described configuration demonstrate, the exemplary high-power x-ray source configuration is capable of significantly higher power operation. The 12-kW power supply was the highest power source available to Applicant for demonstrating the efficacy of the x-ray source configuration for high-power operation.
[0272] One industry technique for characterizing the heating and cooling capacity of an x-ray source is to calculate the fractional heat storage of the x-ray source as a function of time under continuous operation of the source. The maximum heat storage capacity of the x-ray source is calculated by summing the heat storage capacity of each of the main components of the x-ray source subject to heating during operation before the components of the x-ray source reach their respective melting points, thus providing a measure of the amount of heat the x-ray source can absorb before the x-ray system overheats based on the mass, specific heat and melting point properties of the components of the x-ray source. Fractional heat storage (i.e., the fraction of the maximum heat storage capacity of the x-ray source) may then be calculated as a function of continuous operation of the x-ray source using a given input power, the heat storage capacity properties of the components discussed above, and any external cooling that may be implemented.
[0273] FIG. 81A illustrates fractional heat storage curves calculated for an x-ray source according to embodiments of the above-discussed configuration operated at low-power (3 kW: heating curve 8503a and cooling curve 8503b) and operation at high-power (12 kW: heating curve 8512a and cooling curve 8512b) and, more specifically, an x-ray source using a copper heat sink, tungsten primary target, beryllium x-ray window and a graphite electron shield. As shown by heating curve 8512a, even after 100 seconds of continuous operation of the x-ray source with 12 kW of input power (70 kV cathode/anode potential and 171 mA electron emission current), the heating of the x-ray source plateaus at approximately 18% of its calculated maximum heat storage capacity; where the input power equals the product of the total thermal conductivity to the outside environment and the net rise in temperature. Cooling curve 8512b illustrates the cooling of this x-ray source configuration as a function of time when the input power is turned off. The calculated cooling capacity of the above-described integrated cooling system is capable of keeping pace with the heating of the x-ray source under continuous operation with 12 kW of input power. As also demonstrated by cooling curve 8512b, the x-ray source configuration is capable of rapidly dissipating the heat generated during operation, cooling the x-ray source on the order of seconds, as discussed in further detail below.
[0274] FIG. 81B illustrates calculated heating and cooling temperature curves for the individual components of the x-ray source as a function of time for continuous operation of the x-ray source at 12 kW of input power. Specifically, curves 8510a and 8510b illustrate the heating and cooling curves calculated for the tungsten (W) anode, curves 8520a and 8520b illustrate the heating and cooling curves calculated for the copper (Cu) heat sink component, curves 8530a and 8530b illustrate heating and cooling curves calculated for the beryllium (Be) x-ray window, and curves 8515a and 8515b illustrate the calculated heating and cooling curves calculated for a stain steel (SS) vacuum chamber. As these curves demonstrate, after 100 seconds of continuous operation with 12 kW of input power, each of the components reach maximum temperatures well below their respective heat storage capacities, that is, well below the melting temperatures of these materials (i.e., W=3432 C., Cu=1085 C., Be=1277 C., and SS=1500 C.), further demonstrating the capability of the high-power x-ray source to operate at significantly higher power levels. It is noteworthy that calculated heating and cooling curves illustrated in FIGS. 81A and 81B discussed above (and FIG. 81C discussed below) did not take into consideration the cooling capabilities of the above-described water cooling system. Thus, embodiment that employ circulating coolant can be expected to have even better thermal properties, allowing for significantly higher power operation.
[0275] By way of comparison, FIG. 82 illustrates the heating and cooling curves calculated by the manufacturer of a commercial broadband x-ray source utilizing a spinning-anode configuration for cooling the x-ray source. There are several striking differences between the thermal properties of the high-power monochromatic x-ray source configuration and the commercial rotating anode broadband x-ray source. First, the heating and cooling curves are calculated for low-power operation. Specifically, curves 8210a and 8210b illustrate heating and cooling curves for 2.8 kW operation (which can reach maximum heat storage capacity), curve 8212a illustrates the heating curve for 1.75 kW operation, curve 8214a illustrates the heating curve for 1 kW, curve 8216a illustrates the heating curve for 650 W operation, and curve 8218a illustrates the heating curve for 400 W operation. Second, the time constants for heating and cooling of the Applicant's x-ray source configuration are measured in seconds (approximately 10 seconds 12 kW operation), while the time constants for the commercial rotating anode broadband source are at least 100-200 times larger and are measured in minutes. At 10 seconds of high-power operation (12 kW), the fractional stored heat energy is approximately 12%, while in steady-state operation (e.g., after 2-3 time constants) the fractional stored heat energy reaches approximately 18%.
[0276] The rapid cooling achieved by Applicant's x-ray source configuration is particularly well-suited for typical exposure protocols for mammography. For example, FIG. 81C illustrates heating and cooling curves for a 7 second exposure at 12 kW input power (curve 8110) and a 2 second exposure at 10.4 KW. As shown, the fractional heat energy is less than 7% for the former and less than 2% for the latter. After the exposure, the x-ray source rapidly cools. FIG. 83 illustrates the actual temperature curves measured for the water-cooled copper heat sink (curve 8320), beryllium x-ray window (curve 8330), and the vacuum chamber (curve 8315) for a 2 second exposure operating the prototype x-ray source at 10.4 KW (65 kV cathode/anode potential and 160 mA electron emission current), demonstrating that the actual thermal properties are consistent with calculated thermal properties. As shown, even at peak heat energy storage, the beryllium window (which has a relatively small heat capacity) does not exceed 160 C. (approximately 12% of its melting temperature) and the cooling system quickly dissipates that heat. The rapid cooling of the x-ray source facilitates multiple possible advantageous operating sequences, such as several successive exposures of 10 seconds and many more at 2 seconds before the x-ray source could be allowed to cool one for about 25-30 sec, operation that is well-suited to obtaining multiple exposures at different view angles for 3-D tomosynthesis imaging procedures. As the calculated and measured heating and cooling curves demonstrate, the x-ray source configuration described herein is capable of operating at significantly higher power (e.g., 25 kW, 50 KW, 75 KW, etc.)
[0277] As discussed above, imaging with monochromatic x-ray radiation provides significant advantages in terms of radiation dose over conventional broadband x-ray sources. This is because only a fraction of the relatively low intensity x-rays at higher energies of the broadband spectrum emitted by conventional sources are useful for imaging while the remaining x-rays either increase the radiation dose received by the patient or degrade the image. Radiation dose refers to the amount of x-ray radiation absorbed by tissue in the body. The radiation dose can be calculated by measuring the intensity of the x-rays emitted by the x-ray source and the intensity of the x-rays transmitted through the tissue being imaged (i.e., the intensity of the x-rays detected by the x-ray detector). The difference corresponds to the radiation dose absorbed by the tissue. Mean glandular dose refers to the amount x-ray radiation absorbed by glandular tissue (which is the tissue of concern with respect to radiation dose for mammography) and is calculated using measured emitted and transmitted x-ray radiation (as discussed above) and models of the distribution of glandular tissue in the anatomy being imaged. As a simple example, if breast tissue were composed of 50% glandular tissue and 50% adipose tissue, the mean glandular dose would be half of the total radiation dose calculated from emitted and transmitted x-ray intensity measurements. The mean glandular dose received by a patient using the monochromatic x-ray sources described herein to acquire a 2-D full field digital mammography (FFDM) image of a 4.5 cm compressed breast is smaller by a factor of 7 and is smaller by a factor of approximately 30 for a 2-D FFDM image of a 9 cm compressed breast compared to the mean glandular dose received by a patient using a conventional commercial broadband x-ray source to in acquiring those same images at the same signal-to-noise ratio (SNR), as shown in the table below.
[0278] For example, FIG. 84 illustrates an FFDM image 8400a of a 4.5 cm thick breast phantom obtained by a commercial broadband x-ray source and an FFDM image 8400b of the same phantom acquired by the prototype monochromatic x-ray source operated at 12 KW (60 kV cathode/anode potential and 200 mA electron emission current). Images 8400a and 8400b have the same SNR, but the mean glandular dose is 1.26 mGy for the commercial broadband source and only 0.18 mGy for the monochromatic x-ray source. Table 1 below shows exposure times and mean glandular doses for Applicant's monochromatic x-ray source operated at low power (1.6 kW), high power (12 kW) and a commercial broadband x-ray source for a 2-D FFDM image of a 4.5 cm and 9 cm compressed breast to obtain the same SNR images, demonstrated the significant reduction in mean glandular dose using a monochromatic x-ray source. As Table 1 also illustrates, high power operation of the monochromatic x-ray source closes the gap in exposure time between low power operation and the commercial broadband x-ray source for a 4.5 cm compressed breast and significantly outperforms the commercial broadband x-ray source for a 9 cm compressed breast in this respect.
TABLE-US-00001 TABLE 1 Compressed Breast Thickness 4.5 cm 9 cm Mean Mean Exposure Glandular Exposure Glandular Time Dose Time Dose (sec) (mGy) (sec) (mGy) Monochromatic X-ray 11 0.18 71 0.46 Source (1.6 kW) Monochromatic X-ray 0.67-1.0 0.18 5.6-7.0 0.46 Source (12 kW) Commercial 0.8 1.26 12.33 13.55 Broadband X-ray Source
[0279] Using a monochromatic x-ray source allows images to be acquired at the same SNR with significantly reduced radiation dose. It is noteworthy that automatic exposure controls on commercial x-ray sources limit exposures to 3 mGy by FDA regulation, and thus images of the same SNR achievable using a monochromatic x-ray source are not possible for thick breast imaging using conventional broadband x-ray sources. As shown in the table above, the disparity between mean glandular dose for monochromatic x-ray versus broadband x-ray exposures is even more pronounced for 9 cm compressed breast imaging. The mean glandular dose for a 9 cm compressed breast using a monochromatic x-ray source achieves nearly a factor of three reduction in mean glandular dose over the conventional broadband x-ray source for the 4.5 cm compressed breast, thus facilitating the ability to perform uncompressed breast imaging for women whose compressed breast thickness is about 4-6 cm. Breast compression is a chief complaint from patients and Applicant's monochromatic x-ray sources provides an unprecedented advance in mammography.
[0280] In addition to the advantage of obtaining images of the same SNR with significantly reduced radiation dose, the capabilities of Applicant's monochromatic x-ray sources allows significantly higher SNR images to be obtained at the same dose as conventional broadband x-ray sources thereby allowing smaller features (e.g., very thin lesions, microcalcifications) to be detected, thus providing an advance in early cancer detection without increasing the radiation dose received by the patient.
[0281] As discussed in the foregoing, SNR is defined as the signal divided by the noise where the signal is the digital conversion of detected x-ray radiation transmitted through the subject matter being imaged referred to as the Gray count and the noise is the standard deviation of the fluctuations in the background intensity (e.g., see FIG. 30). An SNR of 8.5 is an accepted value for successful detection in normal density breast tissue. Thus, the significant reduction in mean glandular dose using monochromatic x-ray radiation provides the ability to take longer exposures to increase the SNR significantly without increasing the mean glandular dose relative to commercial broadband x-ray radiation. SNR increases by a factor of the square root of the factor increase in dose. As illustrated in Table 1 above, the mean glandular dose is larger by a factor or 7 for a 4 cm compressed breast and a factor of almost 30 for a 9 cm breast for the commercial broadband x-ray source. The SNR may be increased for a monochromatic x-ray source by up to a factor of the square root 7 and the square root of 30, respectively, allowing for an increase in the SNR from 8.5 to up to 22.5 for a 4 cm breast and up to 46.5 for a 9 cm breast (and the range of SNR increases therebetween for breast thickness between 4 cm and 9 cm) without increasing the mean glandular dose relative to the commercial broadband x-ray system by increasing the exposure time (which increases by the same factor as the radiation dose), which is made realizable by high power operation of the monochromatic x-ray source. Significant SNR increases may thus be obtained while still reducing radiation dose relative to the commercial broadband x-ray source.
[0282] FIG. 85 illustrates signal-to-noise ratio curves versus mean glandular dose for a monochromatic x-ray source configured as described herein in accordance with some embodiments (curves 8545M and 8590M) and for a conventional broadband x-ray source (curves 8545B and 8590B) for 4.5 cm and 9.0 cm breast tissue. FIG. 85 also shows the FDA regulated limit on mean glandular dose at 3 mGy relative to these curves. As shown, by curves 8545M and 8545B, a monochromatic x-ray source in accordance with embodiments described herein is capable of acquiring an image with an SNR value of almost 35 for a 4.5 cm breast image before reaching the FDA regulated mean glandular dose limit, whereas the conventional broadband x-ray source is only able to acquire images with SNR values of approximately 13 before exceeding the limit. For a 9 cm breast image, a monochromatic x-ray source can acquire an image with an SNR of approximately 18 before exceeding the dose limit while a broadband x-ray source is limit to acquiring images with an SNR less than 4, as illustrated by curves 8590M and 8590B, respectively. As illustrated in Table 1, high-power operation of a monochromatic x-ray source exhibits exposures times that allow for taking advantage of this increased SNR without unduly long exposure times.
[0283] Having thus described several aspects and embodiments of the technology set forth in the disclosure, it is to be appreciated that various alterations, modifications, and improvements will readily occur to those skilled in the art. Such alterations, modifications, and improvements are intended to be within the spirit and scope of the technology described herein. For example, those of ordinary skill in the art will readily envision a variety of other means and/or structures for performing the function and/or obtaining the results and/or one or more of the advantages described herein, and each of such variations and/or modifications is deemed to be within the scope of the embodiments described herein. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments described herein. It is, therefore, to be understood that the foregoing embodiments are presented by way of example only and that, within the scope of the appended claims and equivalents thereto, inventive embodiments may be practiced otherwise than as specifically described. In addition, any combination of two or more features, systems, articles, materials, kits, and/or methods described herein, if such features, systems, articles, materials, kits, and/or methods are not mutually inconsistent, is included within the scope of the present disclosure.
[0284] All definitions, as defined and used herein, should be understood to control over dictionary definitions, definitions in documents incorporated by reference, and/or ordinary meanings of the defined terms.
[0285] The indefinite articles a and an, as used herein in the specification and in the claims, unless clearly indicated to the contrary, should be understood to mean at least one.
[0286] The phrase and/or, as used herein in the specification and in the claims, should be understood to mean either or both of the elements so conjoined, i.e., elements that are conjunctively present in some cases and disjunctively present in other cases. Multiple elements listed with and/or should be construed in the same fashion, i.e., one or more of the elements so conjoined. Other elements may optionally be present other than the elements specifically identified by the and/or clause, whether related or unrelated to those elements specifically identified. Thus, as a non-limiting example, a reference to A and/or B, when used in conjunction with open-ended language such as comprising can refer, in one embodiment, to A only (optionally including elements other than B); in another embodiment, to B only (optionally including elements other than A); in yet another embodiment, to both A and B (optionally including other elements); etc.
[0287] As used herein in the specification and in the claims, the phrase at least one, in reference to a list of one or more elements, should be understood to mean at least one element selected from any one or more of the elements in the list of elements, but not necessarily including at least one of each and every element specifically listed within the list of elements and not excluding any combinations of elements in the list of elements. This definition also allows that elements may optionally be present other than the elements specifically identified within the list of elements to which the phrase at least one refers, whether related or unrelated to those elements specifically identified. Thus, as a non-limiting example, at least one of A and B (or, equivalently, at least one of A or B, or, equivalently at least one of A and/or B) can refer, in one embodiment, to at least one, optionally including more than one, A, with no B present (and optionally including elements other than B); in another embodiment, to at least one, optionally including more than one, B, with no A present (and optionally including elements other than A); in yet another embodiment, to at least one, optionally including more than one, A, and at least one, optionally including more than one, B (and optionally including other elements); etc.
[0288] Also, the phraseology and terminology used herein is for the purpose of description and should not be regarded as limiting. The use of including, comprising, or having, containing, involving, and variations thereof herein, is meant to encompass the items listed thereafter and equivalents thereof as well as additional items.
[0289] In the claims, as well as in the specification above, all transitional phrases such as comprising, including, carrying, having, containing, involving, holding, composed of, and the like are to be understood to be open-ended, i.e., to mean including but not limited to. Only the transitional phrases consisting of and consisting essentially of shall be closed or semi-closed transitional phrases, respectively.
