Use of β-1,3-glucan synthase like 5 in improving clubroot disease resistance and related product development in cruciferous crops

Abstract

The present disclosure provides the use of -1,3-glucan synthase like 5 (GSL5) for the improvement of the clubroot resistance in cruciferous crops as well as related products development, belonging to the area of molecular engineering for plant breeding. GSL5 gene is highly conserved in cruciferous plants and mutation of GSL5 can confer a broad-spectrum and high clubroot resistance to the cruciferous crops, demonstrating that molecular engineering of GSL5 can achieve the improvement of the clubroot resistance in cruciferous crops. The present disclosure provides a key gene and techniques for the improvement of the clubroot disease resistance and durable prevention and control of the clubroot disease in cruciferous crops.

Claims

1. A method for obtaining a Brassica napus plant resistant to clubroot disease, comprising the step of knocking out the GSL5 gene in the plant, wherein the knocking out results in the loss of function of the gene, wherein the GSL5 gene is located in subgenome A of the Brassica napus and has the nucleotide sequence set forth in SEQ ID NO: 2.

2. A method for obtaining a Brassica napus plant resistant to clubroot disease, comprising the step of knocking out the GSL5 gene in the plant, wherein the knocking out results in the loss of function of the gene, wherein the GSL5 gene is located in subgenome C of the Brassica napus and has the nucleotide sequence set forth in SEQ ID NO: 3.

3. A method for obtaining a Brassica rapa plant resistant to clubroot disease, comprising the step of knocking out the GSL5 gene in the plant, wherein the knocking out results in the loss of function of the gene and wherein the GSL5 gene in the Brassica rapa has the nucleotide sequence set forth in SEQ ID NO: 4.

4. A method for obtaining a Brassica oleracea plant resistant to clubroot disease, comprising the step of knocking out the GSL5 gene in the plant, wherein the knocking out results in the loss of function of the gene and wherein the GSL5 gene in the Brassica oleracea has the nucleotide sequence set forth in SEQ ID NO: 5.

Description

BRIEF DESCRIPTION OF FIGURES

(1) FIG. 1 shows that loss-of-function mutation of GSL5 confers a broad-spectrum resistance to the clubroot resistance in A. thaliana. A. the gene structure of GSL5 genetic structure. The mutation gsl5-1, also known as pmr4-1 results in the presence of a stop condon at the position 2220 while the mutation gsl5-2 results in a deletion of sequence at position 484-613; B and C. the mutants gls5-1 and gsl5-2 are highly resistant to the clubroot disease and have no significant impact on plant growth and development; D. GSL5 expression is significantly up-regulated during the secondary infection of P. brassicae in the root cortex; E. GSL5 mutation confers a broad-spectrum clubroot resistance.

(2) FIG. 2 shows the highly conserved characteristic of GSL5 in cruciferous plants; A. the highly conserved protein sequence of GSL5 in the representative cruciferous plants. B and C. the GSL5 from five representatives of cruciferous crops can functionally complement the Arabidopsis gsl5 mutant to restore its susceptibility.

(3) FIG. 3 shows that gene editing of GSL5 in susceptible B. napus, B. rapa and B. oleracea can significantly improve the clubroot resistance; A and B. clubroot resistance test of the homozygous gsl5 mutant plants of the B. napus, B. rapa and B. oleracea; C. the edited target sequence of GSL5 the B. napus, B. rapa and B. oleracea.

(4) FIG. 4 shows that B. napus mutant gsl5 has a broad-spectrum clubroot resistance without growth and development penalties. A: B. napus gsl5 homozygous mutant plants have a broad-spectrum high resistance to different P. brassicae isolates. B: the mutation of gsl5 has no obvious effect on plant growth and development of B. napus.

DETAILED DESCRIPTION OF EMBODIMENTS

(5) The present disclosure provides a use of the GSL5 (Glucan Synthase-Like 5 or Callose synthase 12, CalS12) in improving clubroot disease resistance of the cruciferous crop. Decrease or termination in GSL5 transcription or expression level or mutation or modification of the protein sequence to terminate or change GSL5 function by molecular engineering of GSL5 promoter regions, coding regions, and non-coding regions in the cruciferous crops could confer a broad-spectrum clubroot resistance in cruciferous crops.

(6) The preferred molecular engineering includes but is not limited to the gene editing, EMS mutagenesis, radiation mutagenesis, homologous recombination, and T-DNA insertion.

(7) Preferably, the cruciferous crops include but not are limited to Arabidopsis thaliana, Brassica napus, Brassica rapa, Brassica oleracea, Brassica juncea, and Raphanus sativus. Preferably, the nucleotide sequence of the GSL5 genes include SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 7 and SEQ ID NO. 8. The detailed descriptions are in the following: SEQ ID NO. 1 is the genomic sequence of A. thaliana GSL5; SEQ ID NO. 2 is the genomic sequence of the subgenome A GSL5 of the B. napus; SEQ ID NO. 3 is the genomic sequence of the subgenome C GSL5 of the B. napus; SEQ ID NO. 4 is the genomic sequence of B. rapa GSL5; SEQ ID NO. 5 is the genomic sequence of B. oleracea GSL5; SEQ ID NO. 6 is the genomic sequence of the subgenome A GSL5 of the B. juncea; SEQ ID NO. 7 is the genomic sequence of the subgenome BGSL5 of the B. juncea; and SEQ ID NO. 8 is the genomic sequence of R. sativus GSL5. In view of the highly conserved characteristics of GSL5 in the cruciferous plants, the GSL5 genes of other cruciferous plants that were not mentioned should also be listed into the protective scope of the present disclosure.

(8) The present disclosure further provides a nucleotide sequence for gene editing of the cruciferous crop GSL5 which is shown in SEQ ID NO. 9 or SEQ ID NO. 10. The cruciferous crop includes B. napus, B. rapa and B. oleracea crops. The GSL5 target sequences of B. napus, B. rapa and B. oleracea are completely identical and contain a length of 20 bases with the 3 end containing an NGG motif, where N represents any one of the bases A, G, C, and T. In view of the highly conserved characteristics of GSL5 in the cruciferous plants, the consensus sequences of the GSL5 genes of all cruciferous crops containing above characteristics should be listed into the protective scope of the present disclosure.

(9) The present disclosure further provides a recombinant vector containing the above nucleotide sequence. This recombinant vector can be transfected into the cruciferous crop to obtain clubroot resistant materials. The gene editing of GSL5 can result in insertion, deletion or mutation in the exon regions.

(10) The present disclosure further provides a recombinant strain containing the recombinant vector.

(11) The technical solutions provided by the present disclosure will be described in detail in several examples below that, however, should not be viewed to limit the protective scope of the present disclosure.

Example 1: Mutation of A. thaliana GSL5 and Test of the Broad-Spectrum Clubroot Resistance

(12) The A. thaliana mutant gsl5-1, also known as pmr4-1 (Stock No. CS3858), was ordered from the Arabidopsis thaliana Biological Resource Center, containing a mutation from G to A at the position 2220 (gene No. AT4G03550), resulting in the presence of stop codon and loss-of-function mutation of GSL5 protein. The A. thaliana mutant gsl5-2 was obtained by gene editing, and this mutant had a deletion in the first exon at the position 484-613, resulting in a frameshift mutation of the coding region and loss-of-function of GSL5.

(13) FIG. 1 shows that loss-of-function mutation of GSL5 confers a broad-spectrum resistance to the clubroot resistance in A. thaliana. Four target sites for gene editing were designed in the first exon of GSL5 with the target site sequences as follows: sgRNA1: 5-ACGAAACCGACGAACAACCGCGG-3, shown in SEQ ID NO. 11; sgRNA2: 5-TATTGATTCTCTCGATTCCGCGG-3, shown in SEQ ID NO. 12; sgRNA3: 5-GAACGCCATTGAACATACGGCGG-3, shown in SEQ ID NO. 13; sgRNA4: 5-GATTGCCTCGATGAGAACACCGG-3, shown in SEQ ID NO. 14;

(14) Primers used for PCR identification of gene-edited progeny plants were: GSL5-F1: 5-CGCCGTCTCAGAGCTACAA-3, shown in SEQ ID NO. 15; GSL5-R1: 5-GGCGGCTTGAAGGAACAAAG-3, shown in SEQ ID NO. 16.

(15) The GSL5 gene used to complement gsl5-1 was the full length of the genomic region with its native promoter (2500 bp upstream of the start codon). The genomic region of GSL5 was cloned from A. thaliana ecotype Col-0, the primers and sequencing were completed by Tsingke Biotechnology Co., Ltd. (Beijing). The primers used to clone the A. thaliana GSL5 promoter and gene fragment were:

(16) TABLE-US-00001 AtGSL5F: GTCGACCTGCAGGCATGCCTGTCTTAAATGGACATTTGTAGTAACAAA; AtGSL5R: AAGTTCTCTCCTTTACTGACATCGCCTTTTTGATTTCTTC;

(17) As shown in SEQ ID NO. 17 and SEQ ID NO. 18, the targeted sequence is incorporated into the expression vector PBI121 by double enzyme digestion (enzyme cutting sites were HindIII and Kpn I) and homologous recombination. After verification by sequencing, the recombinant vector was transformed into the agrobacterium strain GV3101 subjected to transformation following the agrobacterium-mediated flower dipping method. The progeny plants were screened by using kanamycin resistance and positive plants were further identified by PCR to amplify a fragment of the kanamycin gene. The primers were in the follows:

(18) TABLE-US-00002 KanR-jcF: CCTGTTCCAAAGGTCCTGCA; kanR-jcR: TGTCATACCACTTGTCCGCC;

(19) As shown in SEQ ID NO. 19 and SEQ ID NO. 20, the obtaining of the 500 bp PCR product demonstrated the transgenic plants overexpressing GSL5. By crossing the gsl5-1 plants with GSL5 overexpression plants, the progeny plants were identified with PCR to amplify the kanamycin gene (the primers were the same as the aforementioned) to screen the complemented gsl5-1 GSL5 plants. Clubroot resistance test of Col-0, gsl5-1, GSL5 and gsl5-1 GSL5 plants was carried out in a plant greenhouse. P. brassicae strains were collected from the diseased plants across China. Two-week-old seedlings were used for inoculation of different P. brassicae isolates with the resting spore suspension (108/plant) and the disease severity was investigated 30 days after inoculation according to the disease scale specified by the national industry standard of China Technical Code of Practice for Evaluation of Clubroot Disease Resistance in Oilseed Rape (NY/T 3621-2020). The material with a disease index 10 is considered to be highly resistant.

Example 2: The Highly Conserved Characteristics of GSL5 in Cruciferous Plants

(20) The homologs of Arabidopsis GSL5 were identified with the online collinearity analysis tool of the BRAD database (www.brassicadb.cn/#/syntenic-gene/) in the genomes of B. napus, B. rapa, B. oleracea, B. juncea, R. sativus. The genome of the allotetraploid crops B. napus and B. juncea contained two GSL5 homologs while the diploid crops B. rapa, B. oleracea and R. sativus contain only one GSL5 homolog. Multiple sequence alignment of the GSL5 from different cruciferous plants was carried out with an online tool COBALT (www.ncbi.nlm.nih.gov/tools/cobal-t/re_cobalt.cgi) and was virtualized with the software Jalview. The genomic region of GSL5 from different cruciferous crops including its native promoter (2500 bp upstream of the start codon) was respectively cloned and connected to PBI121 expression vector. The agrobacterium containing the constructed vector was transfected into Arabidopsis gsl5-1 mutant and the progeny plants were identified using PCR. The resultant complemented plants were used for clubroot resistance test as the methods mentioned in Example 1. The primer sequences used to clone the genomic region of GSL5 from different cruciferous crops were shown in Table 1.

(21) TABLE-US-00003 TABLE1 TheprimersequencesusedtoamplifythegenomicregionofGSL5 fromdifferentcruciferouscrops. Serial Amplified number Species gene Primer Primersequence SEQID Brassicanapus BnaA09.GSL5 Forward TATGACCATGATTACGCCCAATTTGCGGCCAAGTTC NO.21 CA Reverse ACTAGTCAGATCTACCATTCAAGACCTTCTTTTTTC NO.22 AACTTCGAC BnaC09.GSL5 Forward TATGACCATGATTACGCCGCTTGTCTTGCTTGTTTT NO.23 TGCTC Reverse ACTAGTCAGATCTACCATTTAAGACCTTCTTTTTTC NO.24 AACTTCGACA Brassicarapa BraGSL5 Forward TATGACCATGATTACGCCCGATAAGGAAACGAGA NO.25 GAGGTTG Reverse ACTAGTCAGATCTACCATGCTGTAACGTTTCAGAC NO.26 AATAACC Brassica BolGSL5 Forward TATGACCATGATTACGCCGTGTGTTTCGGAAAGCA NO.27 oleracea GCAAAC Reverse ACTAGTCAGATCTACCATACTGAAACCCAGGCATC NO.28 CACG Brassicajuncea BjuA09.GSL5 Forward TATGACCATGATTACGCCGTTAGGTGACGACTATA NO.29 TCAGCAT Reverse ACTAGTCAGATCTACCATGAGAGAAAGATATCAAAT NO.30 CTTGCAC BjuB08.GSL5 Forward TATGACCATGATTACGCCGCTAATCTTGAACAAGT NO.31 CCTGGAT Reverse ACTAGTCAGATCTACCATGGAAGACGTGAGATAT NO.32 GAATGCAA Raphanus RsGSL5 Forward TATGACCATGATTACGCCGTACCTGTAATTAGTCA NO.33 sativus ACTGTTC Reverse ACTAGTCAGATCTACCATCACCATCTCCAAGATCC NO.34 ACCAC

(22) The results were shown in FIG. 2. A. the highly conserved protein sequence of GSL5 in the representative cruciferous plants. B and C. the GSL5 from five representatives of cruciferous crops can functionally complement the Arabidopsis gsl5 mutant to restore its susceptibility. B. napus (BnaA09.GSL5, BnaC09.GSL5), B. rapa (BraGSL5), B. oleracea (BolGSL5), B. juncea (BjuA09.GSL5, BjuB08.GSL5) and R. sativus (RsGSL5).

Example 3: Knocking Out of GSL5 Genes of B. napus, B. Rapa and B. oleracea Achieved the Improvement of the Broad-Spectrum Clubroot Resistance Breeding

(23) The cruciferous crops for gene editing of GSL5 include the B. napus spring variety Westar and hemi-winter variety Zhongshuang 11, the B. rapa ssp. chinensis variety Chinese cabbage F554, and the B. oleracea ssp. capitata variety HXF. The gene editing vector pYLCRISPR/Cas9 was used to knock out the GSL5 gene from above crops. Two target sites for gene editing were designed in the first exon of GSL5, and the target sequences were in the following: sgRNA1: 5-ACACGAACATCTGGAAGCAGAGG, shown in SEQ ID NO. 9; sgRNA2: 5-GAAAGCCACCACAGCGTAAAGG, shown in SEQ ID NO. 10; The agrobacterium containing the constructed vectors were used to transfect the hypocotyl of above crops. The T1-generation transgenic plants were self-pollinated to generate the T2 population for screening the homozygous mutant gsl5. The primer sequences used to amplify the targeted editing sites of GSL5 from above crops were listed in the following:
B. napus A Subgenome GSL5: BnGSL5A-F: GACGCTGGCTCGCAACGGT, shown in SEQ ID NO. 35; BnGSL5A-R: CGGCCGCCCCAATCCATACC, shown in SEQ ID NO. 36;
B. napus C Subgenome GSL5: BnGSL5C-F: ACGCTGCCTCGCAACGGC, shown in SEQ ID NO. 37; BnGSL5C-R: TGGCCGCCCAAGTCCATACCT, shown in SEQ ID NO. 38; The primers used to amplify the target site of GSL5 from B. rapa were the same as that used for amplification of the targeted sites from B. napus A subgenome.
B. oleracea GSL5: BoGLS5-F: ACGCCTGGCTCGCAACGGC, shown in SEQ ID NO. 39; BoGSL5-R: CGGCCGCCCCAATCCATACC, shown in SEQ ID NO. 40; Clubroot resistance test of the gsl5 mutant of above crops was performed as the methods mentioned in Example 1.

(24) FIG. 3 shows that gene editing of GSL5 in susceptible B. napus, B. rapa and B. oleracea can significantly improve the clubroot resistance; A and B. clubroot resistance test of the homozygous gsl5 mutant plants of the B. napus, B. rapa and B. oleracea; C. the edited target sequence of GSL5 the B. napus, B. rapa and B. oleracea.

(25) The gsl5 mutant of B. napus variety Westar were inoculated with different isolates of P. brassicae for clubroot resistance test. The results show that the gsl5 mutant plants have a broad-spectrum and high resistance to different isolates of P. brassicae (FIG. 4A). The gsl5 mutation had no obvious effect on the growth and development of the B. napus plants (FIGS. 4B and C).

(26) The above clauses are only the preferable embodiments of the present disclosure. It should be noted that for those who possess the basic skills of the molecular engineering, further improvements and modifications of GSL5 in order to improve the clubroot resistance in cruciferous crops should be regarded as the protective scope of the present disclosure.

(27) TABLE-US-00004 SEQIDNO.1 CTGTCTTAAATGGACATTTGTAGTAACAAAACCGACCATCAGCAAATTAA CGTTAACGTTGCTCTAATCGTGTGTATTTTTCTAATGCTTGGTGAAGCAC ATGCGACCATTTGTTGTGTCAGAACAAAAGGAAGATTCCACATTTAGAAT TTAGATTATAATCCCACATGCCTATTATTTAAACATATGTATACTGTAAT AAATTAGTCCCAGAAGAGCATTTCATCATACTGTATAATTAATCAAATTT AAAAAACATTTGTGTTGAAGAGAAGATGACTAGATTCACTTGATTTTTTT TAATACTGATTGGTCGTTTGACCAGTCAGGATCCAGACTGAAATATTCTC AAAAGGTATGAACTATTTTAATGAAATATTTGAGCTGAGAATTTGCTTAT GGGACATTCTATCCTTCTAAAGAAATCATTAGAAAATGGAGAAAAAGTTA CTAGAAAAAGAGAGGGAAATGGGGCGAGAGTATGAAGAAAGGGTCCCATG TGAATCTAATAATTGAAAAGCAAATATGAGATTTATTTTAGGGTTCTTGT TTTAGCGTCCAAAGCGGTCGCAGTTGCCGTTCAGCGACTTTTCTCTGTTT ATGAAATAAAAACGCTCCACTTGTTCTTTTCTTCTTTCAACCCACTTTGT TATAACTATTAACAAATATTGCTTGGTCCAAATTTTATTATACTGAATTA TTTTAGTTTTTTTGTATCATCATCCTCAATGTTAGTTTTGAAATCCTAGG TCAGTAAGTCAATAACGAAAATGACAAGTTTAATTTTGTAATTGGAACTT ACATGTCACGGTCTTTGTTTACGATCATTGCCACGAATTGTTTAGATACG GGCTTTTTTTTTCTTTCCGTGTTGATGATTATCGTTTCTTCTTACATATC TTGATCAATCACTAACATTTACATAACCTACAATTTTGTAATATAATTGC AATACTCGAGATCTTCAAATGGTGATACTGTTAATAAAATTACGAACTTT TAATCATCATCAAAATCTATAGAAAAAGATACATAGGACCAAAACAAGCC TAAAACAAAGAGTTATAATTTACAAATAAATGCATGTATTTTGTTACTTT TGTTAAGGATTTTCATATCAATGCATGCATAATGCATTCTCTTTTTATTT TATTTATAATGCATTCTTTTATAATATTCGGATCCAAAATTATGAATTAA TTCCAGATTGCCATAAATGTCTTTCTTTGTTTATGCTGACTTTTTTCTTT TCTTAACTTATATAGTAAGTAAACCAGAAAGGTGGAAGATACAAAGCAAT TTCATTGCATTAATAAACTTCAAATGTATTATCCAATAATCAAAATTTAT CTAGTAATTCACAAAAAAAAAAAAATCTGTCTATCATTCAAAATTTCACC AATTTGGATAAATATCTAGAAAATTTTAAAATACAATTCAATAACACTAT TAACATATCAATCAATATATAACATTGCAAAAGTTTACTTGATCATTAGT ATATTCATTTTAAGGTTAAAAGATCTTTAAGAAAAGGAAATTCAAATTAT ATTGTTGGAAAAAAATACAAATCAAAGACAGCAAAAAAAGTAACAAAAAA AAAAGGTAGAAGAAACTGAAACGCGGAAAGGAGGCAAAATCTTCTCGTCG TCGTTGTCGCCGTCTTCAGAGCTACAAACGAAAAAACTCGCTTCCGTTTC GATTTCTCCATTGTTATTGTTTCTTCAGTGAAGCTTTTTTCTTCGAGAAA TTTCTAAGATCTACCACATGCTACTATGAGCCTCCGCCACCGCACCGTCC CGCCGCAAACCGGACGGCCGTTGGCGGCGGAAGCTGTCGGAATCGAAGAG GAGCCGTACAATATCATTCCCGTTAACAATCTCCTCGCCGACCATCCTTC ACTCCGTTTTCCCGAGGTTCGTGCCGCCGCTGCTGCTCTTAAAACCGTTG GAGACCTTCGTCGTCCGCCGTATGTTCAATGGCGTTCTCACTACGATCTC CTCGACTGGCTCGCCTTGTTCTTCGGTTTCCAGAAAGATAACGTTCGTAA CCAGCGTGAGCATATGGTGCTTCATCTCGCAAATGCTCAGATGCGTCTCT CTCCGCCGCCGGATAATATTGATTCTCTCGATTCCGCGGTTGTTCGTCGG TTTCGTCGGAAACTTCTCGCTAACTACTCTAGCTGGTGTTCGTATTTGGG GAAAAAATCAAATATCTGGATCTCAGATCGGAACCCTGATTCGAGACGAG AGCTTCTCTATGTTGGACTCTATCTTCTCATTTGGGGAGAGGCTGCGAAT CTTCGGTTCATGCCTGAATGTATCTGTTACATCTTCCATAACATGGCCTC TGAGCTCAACAAAATCTTAGAGGATTGCCTCGATGAGAACACCGGCCAAC CTTACTTGCCTTCTCTCTCAGGCGAAAACGCTTTCTTAACCGGCGTCGTT AAACCTATTTACGATACTATCCAAGCTGAGATTGATGAGAGCAAGAACGG TACAGTTGCGCATTGTAAGTGGAGGAACTACGACGATATCAATGAGTACT TCTGGACTGATCGGTGTTTCAGCAAATTGAAATGGCCGCTTGATTTGGGA AGCAATTTCTTTAAGAGTAGAGGCAAAAGTGTAGGGAAAACTGGTTTCGT GGAGCGCAGGACGTTCTTCTACCTTTACAGGAGTTTTGATCGACTTTGGG TGATGCTAGCTTTGTTCCTTCAAGCCGCCATTATAGTAGCTTGGGAGGAA AAGCCAGATACCTCGTCGGTAACAAGGCAGCTGTGGAATGCTCTGAAGGC AAGAGATGTTCAGGTGAGACTATTGACCGTGTTCTTGACATGGAGTGGTA TGCGACTCTTGCAGGCTGTGCTGGACGCGGCTTCACAATATCCCCTCGTT TCCAGAGAGACCAAAAGGCATTTTTTCAGAATGCTGATGAAGGTTATAGC TGCCGCAGTTTGGATTGTAGCTTTCACTGTCCTCTACACTAACATCTGGA AGCAGAAGAGGCAAGACAGGCAGTGGTCCAATGCCGCGACGACTAAGATA TACCAATTCCTTTACGCTGTGGGGGCCTTCTTGGTGCCCGAAATCCTGGC TTTGGCTTTGTTTATTATCCCATGGATGAGAAACTTCCTGGAAGAGACCA ATTGGAAAATATTCTTTGCTCTAACTTGGTGGTTTCAAGGCAAAAGCTTT GTGGGTCGAGGTTTGAGAGAGGGTTTAGTGGACAACATCAAGTACTCGAC TTTCTGGATCTTTGTCCTAGCTACAAAGTTTACATTTAGTTACTTCCTGC AGGTTAAGCCAATGATTAAACCCTCAAAGCTGCTATGGAACTTAAAGGAT GTCGATTATGAGTGGCATCAGTTTTATGGAGACAGCAATAGGTTTTCTGT CGCATTGTTATGGTTGCCAGTTGTGTTGATATATCTGATGGATATCCAAA TTTGGTACGCAATCTATTCTTCGATTGTTGGTGCTGTTGTTGGGCTGTTT GATCATCTGGGGGAGATCAGGGACATGGGACAGCTGAGGCTAAGGTTTCA ATTCTTTGCTAGTGCTATTCAATTCAACCTAATGCCTGAGGAACAACTCC TGAATGCTAGAGGCTTTGGTAACAAGTTCAAGGACGGCATTCATAGGTAG TCCGTGGAAGCATGCTACTAATATTCCTAAATAATTTTCTGTACAACGCT TGACTTGACTGTACAAGCTGTGAAATTTTACTTTTGTTAACGCAGATGCT GCATATAATTAAATTTTTCAATATTGTAATAACTTGAGGTTGTGTACTGT ATGCAGATTGAAGCTAAGGTATGGATTTGGGAGGCCGTTTAAGAAACTTG AGTCGAATCAGGTCGAGGCCAACAAGTTTGCGTTGATCTGGAACGAAATC ATCTTAGCTTTCAGAGAAGAGGATATAGTTTCTGATCGTGAAGTAGAGCT ACTGGAGCTGCCAAAGAATTCCTGGGATGTGACGGTTATTCGCTGGCCGT GTTTCTTGTTGTGCAATGAGCTTTTGCTTGCACTGAGCCAGGCCAGAGAG CTGATAGACGCACCTGATAAATGGCTGTGGCACAAAATATGCAAGAATGA ATACAGGCGTTGTGCTGTAGTTGAGGCATATGACAGCATCAAACATCTAT TGCTCTCAATCATCAAAGTTGACACTGAAGAACATTCGATAATTACGGTC TTCTTTCAGATAATTAATCAGTCCATTCAGTCAGAGCAGTTCACCAAGAC CTTTAGAGTGGACCTGCTGCCAAAAATTTATGAAACACTGCAGAAATTGG TTGGGCTGGTAAATGATGAGGAAACAGATAGTGGGCGGGTGGTGAATGTT CTGCAGTCTCTTTATGAGATTGCAACTCGACAGTTCTTTATAGAGAAGAA GACAACTGAACAGCTATCTAATGAAGGTTTAACTCCTCGAGACCCAGCCT CAAAGTTGCTGTTTCAAAATGCTATTAGGCTTCCTGATGCAAGCAATGAA GACTTCTACCGGCAGGTTAGGCGTTTACACACGATTCTCACCTCTAGGGA CTCTATGCACAGCGTCCCTGTGAATCTAGAGGCGAGACGGCGGATTGCTT TCTTCAGTAATTCGCTTTTCATGAACATGCCTCATGCCCCTCAGGTTGAG AAAATGATGGCGTTCAGTGTTCTGACTCCATATTACAGTGAGGAAGTTGT ATACAGCAAAGAACAGCTCCGAAATGAGACTGAGGATGGGATTTCCACCC TATACTACCTGCAGACAATTTATGCTGATGAATGGAAAAATTTCAAGGAA CGGATGCATAGGGAAGGAATCAAGACAGATAGTGAGTTGTGGACAACCAA GCTGAGAGACCTCAGGCTTTGGGCTTCCTACAGAGGTCAGACATTGGCAC GTACAGTTCGTGGGATGATGTACTACTACCGGGCTCTTAAGATGCTCGCT TTTCTTGACTCTGCGTCTGAAATGGACATTCGGGAGGGTGCTCAGGAGCT TGGTTCAGTGAGGAATTTGCAGGGAGAACTGGGTGGTCAATCTGATGGGT TTGTCTCTGAAAACGACCGATCTTCCTTAAGCAGAGCAAGTAGTTCCGTG AGTACGCTGTATAAAGGCCATGAGTATGGGACTGCATTGATGAAATTCAC ATATGTTGTGGCGTGTCAGATCTACGGGTCTCAAAAAGCAAAGAAAGAGC CTCAGGCAGAGGAAATTCTGTATCTGATGAAGCAGAACGAAGCTCTCCGT ATTGCATATGTGGATGAGGTGCCTGCGGGAAGAGGAGAGACTGATTATTA CTCCGTTCTGGTGAAATACGATCACCAGTTGGAGAAGGAAGTGGAAATAT TCCGTGTGAAGCTACCTGGTCCAGTGAAGCTGGGCGAGGGAAAGCCAGAG AACCAGAATCATGCAATGATCTTTACCCGTGGTGATGCTGTTCAGACCAT TGATATGAACCAAGACAGTTATTTTGAGGAAGCTCTCAAGATGAGAAATT TGCTCCAGGAGTACAACCATTATCATGGTATCAGAAAACCAACTATTCTT GGTGTCAGGGAGCATATCTTCACGGGATCAGTCTCGTCACTGGCGTGGTT CATGTCTGCTCAGGAGACAAGTTTTGTCACTCTTGGTCAGCGTGTTCTTG CAAACCCACTGAAGGTCAGAATGCATTATGGCCACCCTGATGTATTTGAC AGATTCTGGTTCTTGAGTCGAGGCGGCATCAGTAAGGCTTCCAGAGTTAT AAATATCAGTGAGGACATCTTTGCCGGGTTTAACTGCACGTTAAGGGGGG GAAACGTCACCCACCACGAGTACATTCAGGTTGGGAAGGGTCCACAATTT GGATTATTTCTAACTAACTATACTGCTACAACGTTTTTTTAACGTTTTTA ACGTTTATTAATTATGCAATCTACTTTTGTTATAATTATGTAATTTAACG TTTTTTAATCTTCTAAATTCAAAAAATTTGAGTAACCTTTGTCTTTATGC ATTTTTCAGGTCGGGAAGGGACGGGATGTTGGATTGAATCAGATATCAAT GTTTGAGGCTAAGGTAGCCAGTGGGAACGGAGAGCAGGTTCTCAGCCGAG ATGTGTACCGGCTCGGGCACAGGCTTGATTTCTTCAGAATGTTATCATTT TTCTACACAACTGTAGGGTTTTTCTTCAACACAATGATGGTCATTCTTAC TGTTTACGCTTTCCTCTGGGGACGGGTTTATCTGGCTCTCAGCGGGGTTG AGAAGTCCGCTCTAGCAGACAGTACGGACACCAACGCCGCGCTTGGGGTG ATCCTGAACCAGCAGTTCATCATTCAGCTCGGTCTGTTCACTGCCCTGCC AATGATTGTTGAATGGTCTCTCGAGGAGGGTTTCCTTCTAGCGATATGGA ATTTCATTCGAATGCAGATTCAGCTTTCAGCTGTCTTCTACACATTCTCA ATGGGGACCAGAGCTCACTATTTCGGTCGAACTATTCTCCATGGTGGGGC CAAGTATAGAGCCACTGGACGTGGATTTGTTGTCGAGCACAAGGGATTCA CTGAGAACTACCGACTGTATGCACGCAGTCACTTTGTGAAGGCCATCGAG CTTGGGCTGATCCTCATAGTCTACGCTTCGCACAGTCCGATTGCCAAAGA CTCGTTGATTTACATAGCCATGACTATCACCAGCTGGTTTCTTGTGATTT CATGGATAATGGCCCCATTTGTGTTTAACCCATCAGGATTCGACTGGCTT AAGACAGTCTATGACTTTGAAGACTTCATGAACTGGATCTGGTACCAAGG CAGAATCTCAACGAAATCTGAACAAAGCTGGGAAAAATGGTGGTACGAGG AACAGGACCACCTGAGAAACACCGGGAAGGCAGGATTATTTGTGGAGATC ATCTTGGTCCTCCGGTTTTTCTTCTTCCAGTATGGGATTGTATACCAGCT TAAAATTGCAAACGGATCCACCAGCCTTTTTGTCTACTTGTTCTCATGGA TATACATCTTTGCTATATTTGTGCTCTTCCTAGTCATCCAATACGCCCGT GACAAGTACTCGGCAAAAGCTCACATACGGTACAGGCTTGTCCAATTCCT CCTGATCGTGCTTGCTATACTGGTGATTGTTGCTTTGCTCGAGTTCACGC ATTTCAGCTTCATCGATATCTTCACAAGCCTTCTTGCATTCATCCCAACT GGCTGGGGAATTCTGCTGATCGCACAGACTCAAAGGAAGTGGCTGAAGAA TTACACTATTTTCTGGAATGCTGTTGTCTCTGTTGCTCGCATGTATGACA TATTGTTTGGGATACTCATAATGGTTCCAGTAGCGTTCTTGTCATGGATG CCTGGATTCCAGTCAATGCAAACGAGGATATTATTCAATGAAGCTTTTAG CAGAGGACTTCGCATCATGCAGATTGTCACTGGGAAGAAATCAAAAGGCG ATGTCTAAGTTTAAAAAACGGTAAAGCTCCTTGTTCTCAACACCTTATGT TATGATCGTTTAAATCCTGGATTTCACACCAATGCGGGCTTTAAATTTGT GTAGGTCTTAAGAAGTAAATGGTAGTTCAAATCCTATTGGTATGTGGCGA AGGAATCAGTTGGAGGTTAGTTTTCCCGAAACAACCGAATTCGAAGTTTT GTTTCGTCTAAAGAAAAACTCAGATGCTGATGATTTATCTTTGTATTTTA AACAGGTTTTTGGAGAGTTTGGTTGGATGAGGAATCGGGAAGTTGGTTTG ATTCGGTTAGATGGGTTTAGGGAGATATTTGATTGTCAGTGTGTGTGGAG GGAACTCTGATTCTTGTATGGTTTTTGTTCTAAAGGTACAGCAATTTGTG TAGTGAGGCTTTGTGTATTTGTTCTCCTTCTCTCATTATAGAGCTTTAGA GCATTTTTAGTTTATATTCAGATTGTTATCTAATGTCATCTCGCAGAGCT TTTGTTCACATTTCACATCTTTTCTTCTCCTTCTTAGTAGAGATCAGTTT CAGATTAGATACTTGTCCATATTCCACTACTCTCGTCTATTATCGGTTTC TGCTTGTCAATTTCTGGGTCCAAAATTGAAATA SEQIDNO.2 CTTCCTTCTTTGCCGTCTCTCTTGAAGCTAAGTACACCGATATGGCCGCC TTTAAGTATGTTAAATGCAAACACAAATCGATTATGTTCATCTCATAAGT TATGTGAATATTTTTAGCTAGTAATTGGGTATAACATGTTTTGTAGGTAT TTTGTGATCGCAAACGCTGTCGTGAGTGTTTACAGCTTTCTAGTTCTGTT TCTTCCTAAGGAGAGTTTACTGTGGAAGTTCGTCGTCGTCTTGGATTTGG TAATAATTGTTATTTGGTTTAGTACTTCTCTTCGTTCATTAATTCATTTG CATTCTATCTCTAAGCATAGTTTTTTTCTAAAGGTAATATTATTGTTGAT ATCTAGTAGTTTGATGTGTTCAGAGGAATAAAAGCATTTTTATTGGTGAA ATACTGAAAAATAATAAAATGTTGATTATTATAGTTCAAATAAACAATTG TTTTCTAGAAGAACATAAAGTAATCACAATATTATATTTTGCATGAGAGT TTTTTCACGAAATTCTCATATTTCCTCTTATTATCATTTATCGTTGAGAT ACTTTCTAAGAACTCTTTAATGGAGATGTTCTAGTAAATTAATCTTTGAA CGAAAAGTTAAAACATACACTTTCAAAAAAAAAAAGTTAAAACAAATAAA CTTGAATGTAATGTGTCTTAGTCACACGCTTATTATAGGTTGTTAGGTGA CGACTATATCAGCATACATACGAATTGTCATTAACTTTTGACATTTTTGG TGAATGTATTGGAGGTGATGACAATGCTACTAACGTCAAGCATATCAGCG GCGTTAGCGGTGGCGCAAGTGGGAAAGAAAGGAAACGCAAACGCAGGTTG GCTTCCAATTTGCGGCCAAGTTCCAAAGTTTTGCGATCAGGTCACCGGAG CTCTCATTGCCGGCTTCGTCGCACTCGTCCTCTACGTCTTGTTACTCTTA TACTCTCTTCACTCCGTCGTCGATCCTTTTCTTCTCCAGAAATCTTGAAT CTAACTTCTTTTTTCACTTTCAGTATCGGTTAATATACGTTTTAATATCT ATACTATAACGTCGTTTGTGTATTGTATTTATATGTTTTCTGTTTTAGGT GTCGAGATTGTCATAGTATTTCATTTTTATGGACTAATTAACATTATAGA CTGAACCACCTCTCATAAACTCTTACTCATAATTAAAAAAAAAAATCAAT GCTTCATATATACATCTCTGTCAATCATTGGATTCGTATTTATTATAGTA TCAACAAATTTGTGATACAAACCTAAACATGTGCAATATCTTTAGCTAAC GAAATGGATATAGATACATCTTCCCTAGCTATGGAAATGAGTATTTGATC AAAACGTAATTGCACTTGTTAGTTAGTCATTTCTCTCAGTGTAACAAAAC ACCATTTATGAAAAAACACTGAGCATGGGCAAGTTTCGTCTTCACCTCCG TTAATCTTTTGCATCGTAAAAACAATCGATGTTACAAAACATGTTTTGTT TTAACGTTGTAAAAATATCAGGCTTGATTTGAATGTCATGTTATGCCGAC TTTACTAGTTTGTGTAACCAACTAAGCTATTAAAATATGCGTAATTACAA AACTGTCAGATTTAGTTTCACAAAATCTTTGTAACTTCGCGGTTTTTGAT ATGGAAGTTGCTACAAAAACTGACTTGTGATATTATAATCTTTCGGCAAG AAAAATATATAATACTAATTTCAGAAAGTATTCTGTTGAATTGTTGATCA CCAAATACACATAAACCGGCAGATGTTGACATGTTTACGTGGGATCACTG GGATAGAAGTTTTGCTTCTGTATTAGTATCGCGAACCGGTTTGTAGTAGC GAAAATAACATTATTATTTTCAGATTTCATCATCGTCAAATTCAACGTTA CATTTGAACAGGCTTGTAAAAAGTGGACATGTGGCATGAGTAAAAGATAA AGAAAATTGTGAGCCTTTTTGTTAATACGAAAAAGCCGAAAACGTTATTA TTTCTATCATCGGCAAATTTAATGTTAAATTTGCTCCACATCATTCAGAG GGTATATGTATATTTTTCTAATGCTTCGGTGAAGCACATGCGACCATTTG TTGCGTCAGAAGTCAGAACAAAAGGAAGATTCCATCTAATGGATTATAAT CCCACATGCCCATTTTTAAAACTAGACAAAATAACTTATAATAGTCCCAT AAGAGCATTAAGACAAACTGAACCAAAAAGAATCTTAAATGCTGGTGAAT CTAGTCTCGAATGCTGCTGAACACTCCTGATATTAGAATTTGGCAGAAAA TATTCATACTAATAACAGTAAATACATTTCAAAACAAGAAAATAGTAGTA GTAAATAAAAACAATTAATATGTTATTATTGTTTCTCTTAGCTGTTACCA TTACATTAACAATTTACATTCAATCCTTTTAATGAAAAATATTATAAAAT ATTAAAAGAAGTTATTAGAAAAGGAGAGGGATATGGGGGGGGGGGGGGGA GAGCATGGAGGGGTCCCATGTGTGTTTCGAAAAGCAGCAAACATGACTTT GTAAAGTCTTGTTTTAGCTAGAGTTCCAAAAAAAAAAGAGTTCAAAAAAA AAGAAAAAAAAAAGTCTTGTTTTAGCGTCCAAAGCGGTCTCACTCGCCGT TCAGCTGTTAAATTTTCTTGAAATAAATCGCTCCACTTGTTTTTTATTTT TGTTTCTTTCAACCCACTTGTATTAATAACAATAATGATATTGCTAATCT TGAACAAATCGTGGATTGTCTTTTCTTCCAGTGATATCATCCTTAGTCAA AACATCTCAAATTAAATAAATATATAGTTGTGAATTAAAAAAAAAGGTAT AGAGTTTATAAAATTAGCATTTGCGAATGTTTTTAAAAGTTTGGCGTTTG TATAGATCACTGTCAGTGTCATGAATCATTCGGTGACAGCAAATTTGTAT ATGCCAAAAAAGAGAGTTGATACTTGCCATTCTCGATATTTTGAATTTTT TTTCGTCGACATACAAACTCAACATTTTCGAAATCTTAGATTAAAAACAA AATGGACAAAACGATACTTATTAATGAATTATGTACTAGCGTCTAAACAT TAGTAACATAGATATAATTATAAGAACAAGAAACATATATGCACAAAGCC TCAAACCAAATTTAAATAGTGTTACGAAACAAGGGATGTACTTGTTATGA AAAATTAATGTATAACCATTCTTAGCATTTTTTACCTAACCCTTAAACTT TATAAAGAAAAATATGTAACATTTCGGTGTGTGGTATATAAAAGTATTTT GAAAATCGATTTGATTATTTCTATTATTAAAATGTACTTACTTTTTTTAT CACACATTTATTTACAATTTCAGAGTTAAACATGATTAAGACAAAGTAGT GAAAATATAGATGATCTACCAGAAAATCATTTGCTTTCTGAGTGAGATCA AAATAAAGGCAAAAATAATGTGATGATTGTATATTAAACAATTATTTTGA ATTTGAAAAGAATAACTCATCGAATGAAGCCTATGAACCGAGTAAGCGGT GAAGCGGTTGGACCGTCACAAAAATTATGACCAACAAGAAAATAAAATTG ATATTAGTGAATGATATATTTTGGAAAGTAATAAATTGGTTCCAGATTTC AATACATCAATGTTTTTCTAATGCTGACTTGCTTTTCCTCTTTTTCTTAC ATGATAAGGAAACGAGAGAGGTCGAAGAAACAAAGAAACTTCCTAAGCAT TTAGCAACGCATCTTCAAAAAATCTAGTATTTACCAAGTAAAATCATACA AAATAAGGAAAAAAAGAAGAATATATTTCCCAATTTGGTTTTCACCCGAA AAAAAAACTGTCTTAACAAAATCTTAATGCACCAAATCATATAAGAACTT TATTTGACCATTGTCATTAGTTTTTTCCTTATGGTAATGGATCTTCAAAT AATTTAAATTAAATTAAAAAAAAAAGAAAAGAGAAACAAAAACGCGGAAA GGAGAGCCCAAATCGTCTCCGTCTGTCATTGTCGCAGTCTCTAAAAGAGA AAAACAAATCGCAACGCTTCTCTCTCTCTCCCTATCGTTTGAATCAGTCT CTCAAGATCCACCACCACCACACATGCTACTATGAGCCTCCGCCACCGCA CCGTCCCCTCTCAACCCGGACGGCCCCCGGCGGCGGGCGCAATCGAGGAC GAGCCCTACAACATCATCCCCGTCAACAACCTCCTCGCCGACCACCCCTC CCTCCGCTACCCCGAGGTCCGCGCCGCCGCCGCCGCCCTCAAAACCGTCG GCGACCTCCGCCGCCCCACCTACGTCCAATGGCGCCCCCACTACGACCTC CTCGACTGGCTCGCCCTCTTCTTCGGCTTCCAGAAGGACAACGTCCGCAA CCAGCGCGAGCACCTCGTCCTCCACCTCGCCAACGCCCAGATGCGCCTCA CCCCGCCGCCGGACAACATCGATTCCCTCGATCCCGCCGTCGTCCGCCGC TTCCGCCGCAAGCTCCTCGGTAACTACTCCAGCTGGTGCTCCTACCTCGG GAGGAAGTCCAACATCTGGATCTCGGATCGGAGCCCCGATTCGCGGCGGG AGCTTCTCTACGTCGGCCTCTACCTCCTCGTCTGGGGCGAGGCGGCCAAT CTTAGGTTTATGCCTGAGTGTATCTGTTACATCTTCCACAATATGGCCTC GGAGCTTAACAAGATCTTAGAGGATTGCCTCGACGAGAGCACGGGGCAGC CGTATTCTCCTAAGATCACGGGGGAGAATAGTTTCCTAAACGGCGTCGTT AAGCCTATCTACGACACGATCAGAGCTGAGATTAATGAGAGCAAGAACGG GACGGAGCCGCATTGTAAGTGGAGGAACTACGATGATATTAATGAGTACT TCTGGACGGATAGGTGTTTTAGTAAATTGAAATGGCCGATTGATTTGGGG AGCAGTTTCTTCAAGAACAGCAGAGGTAGCGGAGTTGGGAAGACAGGTTT TGTGGAGAGGAGGACGTTTTTCTACCTCTACAGGAGCTTTGATAGGCTTT GGGTGATGCTTGCTTTGTTTCTTCAAGCTGCTATTATAGTTGCTTGGGAG GAGAAGCCGGGTGGAGGGTCGGTGACGAGTCAGCTCTGGAATGCGTTGAA GTCGACGGATGTTCAGGTGAGGCTTTTGACTGTGTTCTTGACGTGGAGTG GGATGAGGTTGTTGCAGGCTGTGTTGGACGCTGGCTCGCAACGGTCTCTT ATTTCTAGAGAGACCAAACGGCTGTTTTTCAGAATGTTGATGAAGGTTGT GGCTGCTACGGTTTGGATAGTAGCGTTTATTGTTCTCTACACGAACATCT GGAAGCAGAGGAAGCAAGATAGGCAGTGGTCCAGAGCCGCGAATGATAAG ATCTATCAGTTCCTTTACGCTGTGGTGGCTTTCTTGGTTCCTGAGATCCT GGCTTTGGCTCTGTTTATAGTCCCGTGGATAAGGAACTTTCTGGAAGAGA CGAATTGGAAGATATTCTTTGCTTTGACTTGGTGGTTCCAGGGGAAAAGC TTTGTGGGTCGAGGTTTGAGAGAGGGGTTGGTGGACAACATCAAGTACTC GACTTTCTGGATCTTTGTCCTTGCAACGAAGTTCACGTTCAGCTACTTCC TGCAGGTTAAGCCAATGATTAAACCCTCGAAGCTGCTATGGAATTTGAAG GAGGTGGATTATGAGTGGCATCAGTTCTTTGGCGAGAGCAATAGGTTTTC TGTCTTGTTATTGTGGCTGCCAGTGGTGTTGATATACCTGATGGATATCC AAATTTGGTACGCGATCTATTCTTCGATTGTTGGTGCTGTTGTTGGGCTG TTTGATCATCTGGGGGAGATCAGGGACATGGGACAGCTTAGGCTGAGGTT TCAGTTCTTTGCTAGCGCTATTCAGTTCAACCTAATGCCTGAGGAACAAC TCCTGAATGCTAGAGGATTTGGTAACAAGCTTAAGGACGCCATTCATAGG TAAGTCTATTGAAGCATGTTACTGATATTTCTATATAATTTACTATATAG AGTTTGTCTTTAAAGTACAAGCTATAGTATTTTAGTTTTGTTAAAGCAGA TTCTCCGCAATGAACTCGACTTTTTCACATTGTAATAACATTGAGTTTGT GTACTTTATGCAGATTGAAGCTGAGGTATGGATTGGGGCGGCCGTTTAAG AAACTCGAGTCCAATCAGGTTGAGGCTAACAAGTTTGCGCTGATCTGGAA TGAGATAATCTTAGCTTTCAGAGAGGAGGATATAGTCTCTGATCGAGAAG TAGAGCTGCTGGAGCTGCCAAAGAATTCCTGGAATGTGACAGTTATCCGC TGGCCGTGTTTCCTGTTGTGCAACGAACTTTTGCTTGCACTGAGCCAGGC GAAAGAGCTGGTTGACGCACCTGATAAATGGCTGTGGCACAAGATATGCA AGAATGAGTACAGGCGGTGTGCTGTGGTTGAGGCATATGAAAGCATCAAA CATCTGTTGCTCTCAATCATCAAAATTGACACTGAAGAACATAAAATTGT TACAATTTTCTTTCAGATGATTGAGGTGTCTATTCAGGGTGAGCAGTTCA CCAAGACCTTCAAAGTGGACCTTTTGCCAAAGATTTATGAGACACTGCAG AAGTTGGTTGGGCTGTTGAATGATGAGAAAGTGGATGTTGGGCGAGTGGT GAATGGTCTGCAGTCTATTTATGAGATTGCAACACGACAGTTCTTCCTAG AAAAGAAGACGACTGAACAGCTATCTACTGAGGGGTTAACTCCTCATGAT CCAGCCTCAAAGTTACTGTTTCAGAATGCTGTTAGGCTTCCCGATGCAAG CAATGAAGACTTCTTCCGGCAGGTTAGGCGGTTACACACAATTCTCACTT CTAGGGACTCTATGCACAGCGTCCCTGTGAATCTAGAGGCGAGACGGCGG ATTGCCTTCTTCAGCAATTCGCTCTTCATGAACTTGCCTCATGCACCTCA GGTGGAGAAAATGTTGGCGTTCAGTGTTATGACTCCATACTACAGCGAGG AAGTTGTATACAGCAAAGAACAGCTCCGAAATGAGACTGAGGATGGGATT TCAACCTTGTATTACCTGCAGACGATTTATGCCGACGAATGGAAAAATTT TAAGGAACGGATGCGTAGGGAAGGTATAAAGACAGATGTTGAGTTGTGGA CAACCAAGCTGAGAGAGCTCAGGCTTTGGGCTTCCTACAGAGGTCAGACT TTGGCACGTACAATTCGAGGAATGATGTACTATTACAGGGCTCTTAAGAT GCTTGCTTTTCTTGACTCTGCGTCTGAAATGGACATTCGGGAGGATGCTC AGGAGCTTGGTTCAATGAGGAGTTCGCAGGGAAATCGATTGGATGGGGTG GACGATGTAAATGACGGATCTTCTCTAAGCAGAGCAACTAGCTCTGTGAG CATGCTGTATAAAGGCCATGAGCATGGGACTGCATTGATGAAATTCACAT ATGTCGTGGCGTGCCAGATCTATGGGTCTCAAAAAGCGAAGAAGGAGCCT CAGGCAGAGGAAATTCTGTATCTTATGAAGCAAAACGAAGCCCTCCGTAT TGCATATGTGGATGAGGTGCATGCGGGCAGGGAAGAGACTGAGTATTACT CCGTTCTGGTGAAATACGATCACACGTTGGAGAAGGAAGTGGAGATATTC CGTGTGAAGCTACCTGGTCCGGTGAAGCTGGGTGAGGGAAAGCCAGAGAA CCAGAATCATGCAATGATCTTTACCCGCGGTGATGCTGTTCAGACCATAG ATATGAACCAGGATAATTATTTTGAGGAGGCTCTCAAAATGAGAAATTTA CTCCAGGAGTTTAGGCATTATCATGGGATCAGAAAACCAACTATTCTTGG TGTCAGAGAGCACATCTTCACGGGTTCTGTCTCGTCTCTGGCTTGGTTCA TGTCTGCTCAGGAAACAAGTTTCGTCACTCTGGGTCAGCGTGTTCTAGCC AACCCGCTGAAGGTCAGAATGCATTATGGTCACCCTGATGTATTTGACAG ATTCTGGTTCTTGAGTCGAGGTGGCATCAGCAAAGCTTCTAGAGTTATAA ATATCAGTGAGGACATCTTCGCCGGGTTTAATTGCACATTGCGGGGCGGT AACGTCACCCACCACGAGTATATTCAGGTAGGGAAATGTTCATCATTTGG ATATTCTAACTAATTTTATACATCGACAACAATACTATAATTCCACTTTT TTTGTTATAACCTTTTTGTGTGTGCATATGTATTCAGGTTGGGAAGGGTC GAGATGTTGGATTGAATCAAATATCAATGTTTGAGGCTAAGGTAGCCAGT GGGAATGGAGAGCAGGTTCTTAGCCGAGATGTGTACAGGTTGGGTCATAG GCTCGATTTCTTCAGAATGTTATCATTTTTCTACACAACGGTGGGGTTTT TCTTCAACACGATGATGGTCATTCTCACTGTCTACGCTTTCCTCTGGGGC CGGGTTTATCTTGCTCTGAGCGGTGTTGAGAAGTCCGCTCTAGCAGACAG CACAGACACCAACGCAGCGCTTGCTGTGATATTGAACCAGCAATTCATCA TTCAGCTTGGTCTCTTCACAGCTCTGCCAATGATTGTGGAATGGTCTCTC GAGGAGGGTTTCCTTCTCGCGATATGGAACTTCATTCGGATGCAGATTCA GCTTTCCTCTGTCTTCTACACATTCTCAATGGGGACCAGAGCTCACTATT TTGGCCGAACCATTCTCCATGGTGGAGCAAAGTACAGAGCCACTGGGCGT GGATTTGTTGTCGAGCACAAGAGCTTCACTGAGAATTACCGTCTATACGC ACGCAGTCACTTTGTGAAGGCCATCGAGCTTGGGCTGATCCTCATAGTCT ACGCTACGCACAGTCCCATCGCCAAAGACTCATTGATCTATATAGCTATG ACTCTCACCAGCTGGTTCCTCGTGATATCATGGATACTGGCCCCTTTTGT GTTCAACCCGTCAGGATTCGACTGGCTTAAGACGGTCTACGACTTCGAAG GCTTCATGAACTGGATCTGGTATCAAGGCAGGATCTCAACGAAGTCCGAA CAGAGCTGGGAGATATGGTGGTATGAGGAACAGGACCACCTGAGAACCAC CGGTATACCAGGAAGAATCGTGGAGATAATCTTGGACCTTCGGTTTTTCT TCTTCCAGTACGGGATTGTATACCAGCTCAAAATCGCAAACGGATCAACC AGCATTCTCGTCTACTTACTCTCATGGATATACATCTTCGCAGTGTTTGT GTTCTTCCTAGTAATCCAATACGCCCGTGACAAGTACTCTGCGAGAAACC ACATACGGTACAGGCTCGTTCAGTTCCTCCTGATCGTGTTTGGTACACTG GTGATTGTTGCTCTCCTCGAGTTCACGCATTTCAGCTTCGTGGATATCTT CACGAGTCTTCTTGCGTTCGTCCCAACCGGCTGGGGGATCTTGCTGATCG CACAGGCGTTGAGGCCTGCGCTGCAGAAGATCGGGCTTATCTGGAACGCG GTTATCTCCCTTGCTCGGTTATATGACATACTGTTCGGGATAGTCATCAT GGTTCCCGTAGCGTTCATGTCGTGGATGCCTGGGTTTCAGTCGATGCAAA CGAGGATCTTATTCAATGAAGCTTTTAGCAGAGGGCTTCGTATCATGCAG ATTGTCACTGGGAAGAAATCAAAAGGCGATGTCGAAGTTGAAAAAAGAAG GTAAAGCTTCTTATTTACCCAAACATCTTTTTATGTTCTGTTTGTTTGGA ATCTTAAATTACAACAACACTAATGCAAAGCTTTTACAACTTGTGTAGGT CTTGAGGTATATGGTAATTTAAAAGTTGCTGGTTTGCGGCGATGTGACCT GTTGGAGGTTAGTTTTGTATTCTTACAAGTTATGCTTCTTGTCTGAATAG GAACTCAGACACCCGTGTTTTGTCTTCTTCTTATTAAACCAGGTTTTTGG AGAGCTTTGGTTGAGGAAGCTATTCGATTAGATAAATCTTTTAGTGGGGG AGACATATATATATACATTTGTCAGTACTTTGTTAGTGTGTGGAAGTGGG GACGACTCTGATTCTGATTCCTTATGTGGTTATTGTCTGAAACGTTACAG CATTTTGTGAAGTAGGCTTTTGTGCAAGATTTGATCTCTTTCTCTCATTG TAGAGCTTTAGAGCATTTTTTAGTATATGTTTAATCTTTGATTTTCTAAT GTCATTTGCATTCATATTCACATCTTCTTCGTTGGTCTTAAACCAGTTTT CAGATGCTTATCCATTGTCCACTTCTCTATGTATCTGTTTCTTCTGTTTG TTTTCAGTATTGTCTTTTATTCTTTAATCAGTTTTATTTGGACC SEQIDNO.3 AGTGAGTTTGTTCTCCAGCGAGCCGGAGAAGGCATCAACGCAAACCTGGA GGAACAGATTGACCGGTATGTTCATTAACGCTGCAAGCCAGCTTTGATGT TAGCTGCGTAAAGATCCCTGCGTTTACATCAAAACATTACATTGTTTGCT GTGACTAAGGTAACAGAGTAAACGTGTAAAATACTCTGGTGTTTTGGAGA AAACAAACTTACATGGAGCCCTTAATTGCATCTATGGCAGCTTGTGCTGA GAGGAAACCTTCAACGTCCACTTTTCCTTGTAGGTTACTAATATATGCAT ATTTTATTTAAATCAATCCAAATATATGGGTAAAAAACTTTATTTGAGGA TGTACTATATATATGAATGCCTAAGAGTATAATGTACAAAGGTGAAACTT GCCTTGACATTGAAGGAGTAGAGGACTGTTTGCTCCATGGTAGTCATGTA AGTGTGAAGAATAGAGAGATGAAGATCCTCCAAAAAAGCAATAGTCTTAA TAAGTTGTCCTGGTCTTCTTCTTGAAAGTTTCTTGATCATGGCATCAAAC TCTAGCAGCTTCACCTCCACATCAGCCAAGCACGACTCGTTCTCAGCTGT TTCTTCCCGGAGCCCTCCTCCTCCTCCTATACGACTCATGTGACTCTAGG CATTGTAGAAGTTGCTCAAGCTCTCTTACAAACTCTATTCCACCTATGAT CGACGCTTGATCTCTCTGTTATATACATGCATATTAAAAAATATTTTAAA ATAATGAATACAATCACGAAATGAAGATGTATATGTGTTATCATGATACC CATTGAACGTAGGATCCAGACAAAAGAGACTTGAGGTTACGAAGATGCTC GTTCATTTGCTTCCTATTCCTAGCGACCGCAATATGTCTCATTCGTTAGT TTTCTACTTCTTCGCTTGTCTTGCTTGTTTTTGCTCTTCACCTCCTTTGT CATATCATTCTTGTTCTCACTATCTCCTTCTTCTCCTCCAGTAAACCGAC TTGTTATTGTCGTTAACGTCTAAGGATTCACCTAAAAAATTTGGTGCCTG AAAGAAAATAAAGGTGAAGAAATAATTATTAAGATAATATAGGTCAATTG ACTTGGAATCAAAATTTTCACCCTGCAAGTTGACATGGTTTCATACTAAT GTGATACATTAAGACATAGTTTATGGTTTTAATGATTGTTACCTGATCCA TCAGGCATTATACCAAAAGGACAGGCACGGAGGAACTATTCAGTTAGCCC ATGCTCCTGCACAAATTTATCAATCAACTCATATCTAGAAGGATATATGA GAAAAGAAGTTTCTGGTGTTATTAGGAGTTGTGAGGATGATGTTTATTAA GAAATAAACTATATAAGCCTTTACATATAAATTACAAAATACCTTGATTC TCATCCAAGATTCCGGTGTGGATCGATTTATCAATGACATATTTGCAAAA AAAAATAATAGGGTTACCTGGAAGATGGGTGTTGGTGTTTGCTAGACCAA GCAACTCATCTTTGCAGAACCTGAAACGTTCTTGAGGAATTGGTGAACCT GGGTCAGTTAAGTCTTTCAAACCCGTCTCAATATTGAACCGGATCGACAC AGGAGAGTCGGACAGCTTGAAGTCCGGACAGCTCAAAGCCGCTAACAGAG TACACTTAACCAACAGTGAAAAGATGTCTGAATGTGTTTAAGCGGTAGAC GTTCACGGTGGCTTAGGTGAGAGTGGCCTGCAAAGCATGAAAAATTGGAA ACATAAACAAATGAAATAAATATTGCAATCATTAAAAATAAACTAAAGCG CTTGTTAACTTTTTCATAATCAAAAGACATAAGCATATGGATGTCTCTAC ACGGACTATTTGAATTTTAGGTATGAATAAAATATACGAAAAAAGTAAAA AAGAATCAACAATCACAACAATGATCATATCCCAAATATTTGAAGATAAC AAAAACTTATGGAGAATAACGAAGACATGAATGTATTGATCTCCGGTGAA GAACTATTAGGTTTGAAAGTTTCATAACCAAAACACAACAACGCGAGAAA GGATTAAAAAACAAAACAAAACTACATAGTCAAGCCGGATTTACCTTGGC GTCCATGAAGAGAATGTTGACCCTCTCTGTCGCGCTTAACATTCCTATCT TCCCAGAACCTAAGCAAACGGACCTGGGCGGTGGAGGTGCAGCGGCTAGC TTTCAAATCGGCGAGAAAGACGGAGGAATTAGCCATTATCGACTTTGATT TCTTAGAAAACAGTTTATGGGAATGTAGTAGGATTGTGAGAATGATGTTT CTGGGAAGAGCACATACCTTTTTGTAGGAGGAGCTTCACCGCTTGTAAGA GAGATGAGAGTATTGAGTGAGAAATCGTTGAGCTTCATCGTGGAGGATGG ATTTAAAAAGGGCTTTAAGAGTAAGAATCTGTAACAGGTAGATTGCTGGA TCCGTAGGAAGAAGATGAAGCATCTCGATCAAAACCCTAGGGTATGATAT TGCAACGGCGGAGAAGAGAATGAGATGAAACCATAGAATTAAAAACTCTG CGTTTCAGGCATACGTCTTACTCTGCTTTTTAAAGATTGGGCTTTATAAA CCAAAACAATAACAAAGAATGTAGCCCAAACGGAAACAGAATAAATGAAA CGCGGTAAAGTGAACAGATGTCACATAATGATTGGCTGATTTAATTGTCC TACGTGGACAGCTTCTCTGATGCTCATATAACCCTTTTAGTATAGGTTAG ATGATATCATCCTTAGTCAAAAGTCAAAACATCTCAAATTAAATAAGTAT AGAGTTGTGAATTTTTAAAAAAGTATAGAGTATATAAAATTAGCATTTGC GAATGTTTTTAAAAGTTTGGCGTTTGTATGGATCACTGTCAGTGTCATGA ATCATTCGGTGACTGCAAAATTTTATATGACAAAAAAAAAAGAGAGTTGA TACTTACCATTCTCGATATTTTGAAATTTTTTTCGTCGTTAATACAAACT CAACATTTTCGAAATCTTGGATTAAAAAAAAAAAATATGGACAAAACGGT ACTTATTAATTAATTATGTACTAGCGTCTTGACATTATTAATATAGATAT AATTATAAGAACAAGAAACGTATATGCACAAACCCTCAAACCAAATTTAA ATAGTGTTAAAAAACAAGGGATGTACTTGTTATGAAAAATTAATATATAA CCATTCTTAACATTTTTACCTAACCCTTAAACTTTATAAATAAAAATACG TAATATCCCGATAGAAATATTTTAAAATTTTGATTTGATTATTTATGTTA TCAAAGTGCATTTATTTTTTTTTGTCACGTATATATTTAAAATTTCAACA TTAAAAGTGTGTAAGATGGAGTAGTGAAAATATAGACGACTTACCATAAA ATTATTTGTGATATCATTTGAATAAGACTAAAACACGGACAAAAATAATA TAGTGATTGCATTGTTATTAAACAATTATTTGGATTTGAAAAGAAATAAC TCATTGAATGAAGCCTATGAGCCGAGTAAACGGACGTGGATAGCTTAAGC GGTTGGACCGTACAAAATTTATGACCAACAAGAAAATGAAATTGATTTTT TTTTTGACGAAAAAATGAAATTGATTTTAGAAAGTAACAAAATGGTTCCA GATTTCAATACTTCAACGTTTTTTTATGCCGACTTTCTTTTCCTCTTTTA CTTACATGATAAGGAAACGAGAGAGGTTGAAGAAACAAAGAAACTTCCTA AGCATTTAGAAATGTATCTTCAAAAAATCTAGTATTTACCAAGTAAAATC ATTCAAAATAAGGAAAAAAAGAAGAATCTATTTCCCAATTTGGTTTTCAC CGAAAAAAAAATTGTCTTAATAAAATCTTAATGCACCAAATCATATAAGA ACTTTATATGACCATTGTCATTAGTTTTTTCTTTATGGTAATGGATCTTC AAATAATTTAAATTAAATTAAAAAAAAAAAAGAGAAACAAAAACGCGGAA AGGAGAGCCCAAATCGTCTCCGTCTGTCATTGTCGCAGTCTCTCACAGCT AAATAAAAGAGAAAAACAAATCGCAACGCTTCAATATCTCTCTCCCAATC GTTTGAATCAGTCTTCCTCATCACAATCCCCCAAAGATCCACCACACATG CTACTATGAGCCTCCGCCACCGCACCGTCCCCTCTCAACCCGGACGGCCC CCGGCGGCGGGCGCAATCGACGACGAGCCCTACAACATCATCCCCGTCAA CAACCTCCTCGCCGACCACCCCTCCCTCCGCTACCCCGAGGTCCGCGCCG CCGCCGCCGCCCTCAAAACCGTCGGAGACCTCCGCCGCCCCACCTACGTC CAATGGCGCCCCCACTACGACCTCCTCGACTGGCTCGCCCTCTTCTTCGG CTTCCAGAAGGACAACGTCCGCAACCAGCGCGAGCACCTCGTCCTCCACC TCGCCAACGCCCAGATGCGCCTCACGCCGCCGCCGGATAACATCGATTCC CTCGATCCCGCCGTCGTCCGCCGTTTCCGCCGCAAGCTCCTCGGTAACTA CTCGAGCTGGTGCTCGTACCTCGGGAGGAAGTCGAACATCTGGATCTCGG ATCGGAACCCCGATTCGAGGCGGGAGCTTCTCTACGTCGGCCTCTACCTC CTCGTGTGGGGGGAGGCGGCGAATCTTAGGTTTATGCCGGAGTGTGTCTG TTACATCTTCCACAATATGGCCTCGGAGCTTAACAAGATCCTCGAGGATT GCCTCGACGAGAGCACGGGGCAGCCGTACTCTCCTAGAATCACGGGGGAG AATAGTTTCCTAAACGGCGTCGTTAAACCTATTTACGAGACGATCAAAGC TGAGATTAACGAGAGCAAGAACGGGACGGAGCCGCATTGTAAGTGGAGGA ACTATGATGATATTAATGAATACTTTTGGACGGATAGGTGTTTTAGTAAA TTGAAATGGCCGATTGATTTGGGGAGCAGTTTCTTCAAGAGTAGTAGAGG GAGAGGCGTTGGGAAGACAGGTTTTGTGGAGAGGAGGACGTTCTTTTACC TCTACAGGAGCTTTGATAGGCTTTGGGTGATGCTTGCTTTGTTTCTTCAA GCTGCTATTATAGTCGCTTGGGAGGAGAAGCCGGGTGGAGGGTCGGTGAG GAGTCAGCTCTGGAATGCGTTGAAGTCGAGGGATGTTCGGGTGAGGCTTT TGACTGTGTTCTTGACGTGGAGTGGGATGAGATTACTGCAGGCTGTGCTG GACGCTGCCTCGCAACGGCCGCTTATTTCTAGAGAGACCAAGCGGCTGTT TTTCAGAATGTTGATGAAGGTTGTAGCTGCTACGGTTTGGATAATTGCTT TTATTGTTCTCTACACGAACATCTGGAAGCAGAGGAAGCAAGACAGGCAG TGGTCCAGAGCCGCGAATGACAAGATCTATCAGTTCCTTTACGCTGTGGT GGCTTTCTTGGTCCCTGAGATCCTGGCTTTGGCTCTGTTTATAGTCCCGT GGATAAGGAACTTTCTGGAAGAGACCAATTGGAAGATATTCTTTGCTTTG ACTTGGTGGTTCCAGGGTAAAAGCTTTGTGGGTCGAGGTTTGAGAGAGGG GTTGGTGGACAACATCAAGTACTCGACTTTCTGGATCTTTGTCCTAGCAA CGAAGTTCACGTTCAGCTACTTCCTTCAGGTTAAGCCAATGATTAAACCC TCGAAGCTGCTATGGAATTTGAAGGAGGTGGATTATGAGTGGCATCAGTT CTTTGGCAAGAGCAATAGGTTTTCTGTCTTGTTATTGTGGCTGCCAGTGG TGTTGATATACCTGATGGATATCCAAATTTGGTACGCGATCTATTCTTCG ATTGTTGGTGCTGTTGTTGGGCTGTTTGATCATCTGGGGGAGATCAGGGA CATGGGACAGCTTAGGCTGAGGTTTCAGTTCTTTGCTAGCGCTATTCAGT TCAACCTAATGCCTGAGGAACAACTCCTGAATGCTAGAGGATTTGGTAAC AAGCTTAAGGACGCCATTCATAGGTAAGTCTATTGAAGCATGTTACTGAT ATTCCTTTATAATTTACTGTACAGAGTTTGTCTTTACGGTACAAGTTATG GAATTTTAGTTTTGTTAAAGCAGATTCTCTTAACTCGGCTTTTCAACATT GTAATAACCTTGAGTTTGTGTACTTTATGCAGATTGAAGCTGAGGTATGG ACTTGGGCGGCCATTTAAGAAACTCGAGTCTAATCAGGTTGAGGCTAACA AGTTTGCGCTGATCTGGAATGAGATAATCTTAGCTTTCAGAGAAGAGGAT ATAGTCTCTGATCGAGAAGTAGAGCTACTGGAGCTGCCAAAAAATTCCTG GAATGTGACAGTTATCCGCTGGCCGTGTTTCCTGTTGTGCAACGAGCTTT TGCTTGCACTGAGCCAGGCGAAAGAGCTGGTTGACGCACCTGATAAATGG CTGTGGCACAAGATATGCAAGAACGAGTACAGGCGGTGTGCTGTGGTTGA GGCATATGAAAGCATCAAACATCTGTTGCTCTCAATCATCAAAATTGACA CCGAAGAACATAAAATTATTACAATTTTCTTTCAGATGATTGAGGTGTCT ATTCAGGGTGAGCAGTTCACCAAGACCTTCAAAGTGGACCTATTGCCAAA GATTTATGAGACGCTACAGAAGTTGGTTGGGCTGTTGAATGATGAGAAAG TGGATGTTGGGCGAGTGGTGAATGGTCTGCAGTCTATTTATGAGATTGCA ACACGACAGTTCTTCATAGAAAAGAAGACGACTGAACAGCTATCTACCGA GGGGTTAACTCCTCATGATCCAGCCTCAAAGTTACTGTTTCAGAATGCTG TTAGGCTTCCCGATGCAAGCAATGAAGACTTCTTCCGGCAGGTTAGGCGG TTACACACAATTCTCACTTCTAGGGACTCTATGCACAGCGTCCCTGTGAA TCTAGAGGCGAGACGGCGGATTGCCTTCTTCAGCAATTCGCTCTTCATGA ACTTGCCTCATGCACCTCAGGTGGAGAAAATGTTGGCGTTCAGTGTTATG ACTCCATACTACAGCGAGGAAGTTGTATACAGTAAAGAACAGCTCCGAAA TGAGACTGAGGATGGGATTTCAACCTTGTATTACCTGCAGACGATTTATG CCGACGAATGGAAAAATTTTAAGGAACGGATGCGTAGGGAAGGTATAAAG ACAGATGTTGAGTTGTGGACAACCAAGCTGAGAGAGCTCAGGCTTTGGGC TTCCTACAGAGGTCAGACTTTGGCACGTACAGTTCGAGGAATGATGTACT ATTACAGGGCTCTTAAGATGCTTGCTTTTCTCGACTCTGCGTCTGAAATG GACATTCGGGAGGATGCTCAGGAGCTTGGTTCAATGAGGAGTTCGCAGGG AAATCGATTGGATGGTGTTGACGATGTAAATGACCGATCTTCTCTAAGCA GAGCAACTAGCTCTGTGAGCATGCTGTATAAAGGCCATGAGCATGGGACT GCATTGATGAAATTCACATATGTCGTGGCGTGCCAAATCTATGGGTCTCA AAAAGCGAAGAAAGAGCCTCAGGCAGAGGAAATTCTGTATCTTATGAAGC AAAACGAAGCCCTTCGTATTGCATATGTGGATGAGGTACATGCGGGCAGG GGAGAGACTGAGTATTACTCCGTTCTGGTGAAATACGATCACACGTTGGA GAGGGAAGTGGAGATATTCCGTGTGAAGCTACCTGGTCCGGTGAAGCTGG GTGAGGGAAAGCCAGAGAACCAGAATCATGCAATGATCTTTACCCGTGGT GATGCTGTTCAGACCATAGATATGAACCAGGATAATTATTTTGAGGAGGC TCTCAAGATGAGAAATTTGCTCCAGGAGTTTAGGCATTATCATGGGATCA GAAAACCAACTATTCTTGGTGTCAGAGAGCACATCTTCACGGGTTCTGTC TCGTCTCTGGCTTGGTTCATGTCTGCTCAGGAGACAAGTTTCGTCACTCT TGGTCAGCGTGTTCTAGCCAACCCGCTGAAGGTCAGAATGCATTATGGTC ACCCTGATGTATTTGACAGATTCTGGTTCTTGAGTCGAGGTGGCATCAGC AAAGCTTCTAGAGTTATAAATATCAGTGAGGACATCTTCGCCGGGTTTAA TTGCACATTGCGGGGCGGTAACGTCACCCACCACGAGTATATTCAGGTAG GGAAATGTTCATCGTTTGGATATTCTAACTAATTTATACATCGACAACAA TACTATAATTCCACTTTTTTGTTATAACCTTTTTGTGTGTGCATATGTAT TCAGGTTGGGAAGGGTCGAGATGTTGGATTGAATCAAATATCAATGTTTG AGGCTAAGGTAGCCAGTGGGAATGGAGAGCAGGTTCTTAGCCGAGATGTG TACAGGTTGGGTCATAGGCTCGATTTCTTCAGAATGTTATCATTTTTCTA CACAACGGTGGGGTTTTTCTTCAACACGATGATGGTCATTCTCACTGTCT ACGCTTTCCTCTGGGGCCGGGTTTATCTTGCTCTGAGCGGTGTTGAGAAG TCCGCTCTAGCAGACAGCACAGACACCAACGCAGCGCTTGCTGTGATATT GAACCAGCAGTTCATCATTCAGCTTGGTCTCTTCACAGCTCTGCCAATGA TTGTGGAATGGTCTCTCGAGGAGGGTTTCCTTCTCGCGATATGGAACTTC ATTCGGATGCAGATTCAGCTTTCTTCTGTCTTCTACACATTCTCAATGGG GACCAGAGCTCACTATTTTGGCCGAACCATTCTCCACGGTGGAGCAAAGT ACAGAGCCACTGGACGTGGATTTGTTGTCGAGCACAAGAGTTTCACTGAA AACTACCGTCTATACGCGCGCAGTCACTTTGTGAAGGCCATCGAGCTTGG GCTGATCCTCATAGTCTACGCTACGCACAGTCCCATCGCCAAAGACTCAT TGATCTATATAGCCATGACTCTCACCAGCTGGTTCCTCGTGATTTCATGG ATACTAGCCCCTTTTGTGTTCAACCCGTCAGGTTTCGACTGGCTTAAGAC GGTCTACGACTTCGAAGGCTTCATGAACTGGATCTGGTATCAAGGCAGAA TCTCAACGAAGTCCGAACAGAGCTGGGAGATATGGTGGTATGAGGAACAG GACCACCTGAGAACCACCGGTCTACCAGGAAGAATCATGGAGATAATCTT GGACCTTCGGTTTTTCTTCTTCCAGTACGGGATTGTATACCAGCTCAAAA TCGCAAACGGATCAACCAGCATTCTCGTCTACTTACTCTCATGGATATAC ATCTTCGCAGTGTTTGTGTTCTTCCTGGTAATCCAATACGCCCGTGACAA GTACTCAGCGAGAAACCACATACGGTACAGGCTCGTTCAATTCCTCCTGA TCGTGTTTGGTACACTGGTGATTGTTGCTCTCCTGGAGTTCACGCATTTC AGCTTCGTGGATATCTTCACGAGTCTTCTTGCGTTCGTCCCAACCGGCTG GGGAATCTTGCTGATCGCACAGGCTTTGAGGCCTGCGCTGCAGAAGATCG GGCTTATCTGGAACGCGGTTATCTCCCTTGCTCGGTTATATGACATACTG TTCGGGATAGTCATCATGGTCCCCGTAGCGTTCATGTCGTGGATGCCTGG GTTTCAGTCGATGCAAACGAGGATCTTATTCAATGAAGCTTTTAGCAGAG GGCTTCGTATCATGCAGATTGTCACTGGGAAGAAATCTAAAGGCGATGTC GAAGTTGAAAAAAGAAGGTAAAGCTTTTATAACTTGTGTTCTGTTTATGT TTGTTTGGAATCTTAAATTACAACAACACCAATGCAAAGCTTTTATAACT TGTTTAGGTCTTAAGGTATATGGTAACTTAAAAGTCGTTGGTTTTGCGGC GATGTGATCAGTTGGAGGTTAGTTTTCTCAAGACATGGAAGTTTTATAAG TTATTGCTTCTTGTGTGAAGAAGAAGTCATATACATCCATGTTTTGTTTT GTCTTCTTCTTAAAGCAGGTTTTTGGAGAGCTTTGGTTGAGGAATCCGGA AGTTAGATAATCTTTTAGTGGGGGAGACATATATATACACATTTGTCAGT ACTTTGTTAGAGTGTGTGGAAGTGGGGACGACTCTGATTCTGGTTCCTTA TGTGGTTATTGTCTGAAACGTTACAGCATTTTGTGAAGTAGGCTTTTGTG CAAGATTTGATCTCTTTCTCTCATTGTAGAGCTTTAGAGCATTTTTTAGT ATATGTTTAATCTTTTGATTTTCTAATGTCATTTGCATTCATATTTCACA TCTTCTTCGTTGGTCTTAAACCAGTTTTCAGATGCTTATCCATTGTCCAC TTTTCTATGTATCTGTTTCTTCTGTTTGTTTTCAGTATTGTCTTTTATTC TTTAATCAGTTTTATTTGGACCACAACACCA SEQIDNO.4 AAAGTAATAAAATGGTTCCAAATTTCAATACATCAATGGTTTTCTAATGC TGACTTGCTTTTCCTCTTTTACTTAAACGATAAGGAAACGAGAGAGGTTG AAGAAACAAAGAAACTTCCTAAGCATTTACAAATATATCTTCAAAAAATC TAGTATTTACCAAGTAAAATCATACAAAATAAGAAAAAAAAAGAAGAATC TATTTCCCAATTTGGTTTTCACCGGAAAAAAAAAACTGTCTTAACAAAAT CTTAATGCACCAAATCATATAAGAACTTTATTTGACCATTGTCATTAGTT TTTTTCCTTATGGTAATGGATCTTCAAATAATTTAAATTAAATTAAAAAA AAAGAAAAAAGAAACAAAAACGCGGAAAGGAGAGCCCAAATCGTCTCCGT CTGTCATTGTCGCAGTCTCTAAAAGAGAAAAACAAATCGCAACGCTTCAA TATCTCTCTCTCTCTCCCTATCGTTTGAATCAGTCTCCCAAGATCCACCA CCACACATGCTACTATGAGCCTCCGCCACCGCACCGTCCCCTCACAACCC GGACGGCCCCCGGCGGCGGGCGCAATCGACGAGGAGCCCTACAACATCAT CCCCGTCAACAACCTCCTCGCCGACCACCCCTCCCTCCGCTACCCCGAGG TCCGCGCCGCCGCCGCCGCCCTCAAAACCGTCGGCGACCTCCGCCGCCCC ACCTACGTCCAATGGCGCCCCCACTACGACCTCCTCGACTGGCTCGCCCT CTTCTTCGGCTTCCAGAAGGACAACGTCCGCAACCAGCGCGAGCACCTCG TCCTCCACCTCGCCAACGCCCAGATGCGCCTCTCCCCGCCGCCGGACAAC ATCGATTCCCTCGATCCCGCCGTCGTCCGCCGCTTCCGCCGCAAGCTCCT CGGTAACTACTCCAGCTGGTGCTCCTACCTCGGGAGGAAGTCCAACATCT GGATCTCGGATCGGACCCCCGATTCGCGGCGGGAGCTTCTCTACGTCGGC CTCTACCTCCTCGTGTGGGGCGAGGCGGCGAATCTTAGGTTTATGCCTGA GTGTATCTGTTACATCTTCCACAATATGGCCTCGGAGCTTAACAAGATCT TAGAGGATTGCCTCGACGAGAGCACGGGGCAGCCGTATTCTCCTAAGATC ACGGGGGAGAATAGTTTCCTAAACGGCGTCGTTAAGTCAGAACAAAAGGA AGATTCCATCTAATGGATTATAATCCCACATGCCCATTTTTAAAACTAGA CAAAATAACTTATAATAGTCCCATAAGAGCATTAAGACAAACTGAACCAA AAAGAATCTTAAATGCTGGTGAATCTAGTCTCGAATGCTGCTGAACACTC CTGATATTAGAATTTGGCAGAAAATATTCATACTAATAACAGTAAATACA TTTCAAAACAAGAAAATAGTAGTAGTAAATAAAAACAATTAATATGTTAT TATTGTTTCTCTTAGCTGTTACCATTACATTAACAATTTACATTCAATCC TTTTAATGAAAAATATTATAAAATATTAAAAGAAGTTATTAGAAAAGGAG AGGGATATGGGGGGGGGGAGAGCATGGAGGGGTCCCATGTGTGTTTCGAA AAGCAGCAAACATGACTTTGTAAAGTCTTGTTTTAGCTAGAGTTCCAAAA AAAAAAGAGTTCAAAAAAAAAGAAAAAAAAAAGTCTTGTTTTAGCGTCCA AAGCGGTCTCACTCGCCGTTCAGCTGTTAAATTTTCTTGAAATAAATCGC TCCACTTGTTTTTTATTTTTGTTTCTTTCAACCCACTTGTATTAATAACA ATAATGATATTGCTAATCTTGAACAAATCGTGGATTGTCTTTTCTTCCAG TGATATCATCCTTAGTCAAAACATCTCAAATTAAATAAATATATAGTTGT GAATTAAAAAAAAAGGTATAGAGTTTATAAAATTAGCATTTGCGAATGTT TTTAAAAGTTTGGCGTTTGTATAGATCACTGTCAGTGTCATGAATCATTC GGTGACAGCAAATTTGTATATGCCAAAAAAGAGAGTTGATACTTGCCATT CTCGATATTTTGAATTTTTTTTCGTCGACATACAAACTCAACATTTTCGA AATCTTAGATTAAAAACAAAATGGACAAAACGATACTTATTAATGAATTA TGTACTAGCGTCTAAACATTAGTAACATAGATATAATTATAAGAACAAGA AACATATATGCACAAAGCCTCAAACCAAATTTAAATAGTGTTACGAAACA AGGGATGTACTTGTTATGAAAAATTAATGTATAACCATTCTTAGCATTTT TTACCTAACCCTTAAACTTTATAAAGAAAAATATGTAACATTTCGGTGTG TGGTATATAAAAGTATTTTGAAAATCGATTTGATTATTTCTATTATTAAA ATGTACTTACTTTTTTTATCACACATTTATTTACAATTTCAGAGTTAAAC ATGATTAAGACAAAGTAGTGAAAATATAGATGATCTACCAGAAAATCATT TGCTTTCTGAGTGAGATCAAAATAAAGGCAAAAATAATGTGATGATTGTA TATTAAACAATTATTTTGAATTTGAAAAGAATAACTCATCGAATGAAGCC TATGAACCGAGTAAGCGGTGAAGCGGTTGGACCGTCACAAAAATTATGAC CAACAAGAAAATAAAATTGATATTAGTGAATGATATATTTTGGAAAGTAA TAAATTGGTTCCAGATTTCAATACATCAATGTTTTTCTAATGCTGACTTG CTTTTCCTCTTTTTCTTACATGATAAGGAAACGAGAGAGGTCGAAGAAAC AAAGAAACTTCCTAAGCATTTAGCAACGCATCTTCAAAAAATCTAGTATT TACCAAGTAAAATCATACAAAATAAGGAAAAAAAGAAGAATATATTTCCC AATTTGGTTTTCACCGGAAAAAAAAAACTGTCTTAACAAAATCTTAATGC ACCAAATCATATAAGAACTTTATTTGACCATTGTCATTAGTTTTTTCCTT ATGGTAATGGATCTTCAAACAATTTAAATTAAATTAAAAAAAAAAAGAAA AGAGAAACAAAAACGCGGAAAGGAGAGCCCAAATCGTCTCCGTCTGTCAT TGTCGCAGTCTCTAAAAGAGAAAAACAAATCGCAACGCTTCAATATCTCT CTCTCTCTCTCTCCCTATCGTTTGAATCAGTCTCTCAAGATCCACCACCA CACATGCTACTATGAGCCTCCGCCACCGCACCGTCCCCTCTCAACCCGGA CGGCCCCCGGCGGCGGGCGCAATCGAGGACGAGCCCTACAACATCATCCC CGTCAACAACCTCCTCGCCGACCACCCCTCCCTCCGCTACCCCGAGGTCC GCGCCGCCGCCGCCGCCCTCAAAACCGTCGGCGACCTCCGCCGCCCCACC TACGTCCAATGGCGCCCCCACTACGACCTCCTCGACTGGCTCGCCCTCTT CTTCGGCTTCCAGAAGGACAACGTCCGCAACCAGCGCGAGCACCTCGTCC TCCACCTCGCCAACGCCCAGATGCGCCTCTCCCCGCCGCCGGACAACATC GATTCCCTCGATCCCGCCGTCGTCCGCCGCTTCCGCCGCAAGCTCCTCGG TAACTACTCCAGCTGGTGCTCCTACCTCGGGAGGAAGTCCAACATCTGGA TCTCGGATCGGACCCCCGATTCGCGGCGGGAGCTTCTCTACGTCGGCCTC TACCTCCTCGTGTGGGGCGAGGCGGCGAATCTTAGGTTTATGCCTGAGTG TATCTGTTACATCTTCCACAATATGGCCTCGGAGCTTAACAAGATCTTAG AGGATTGCCTCGACGAGAGCACGGGGCAGCCGTATTCTCCTAAGATCACG GGGGAGAATAGTTTCCTAAACGGCGTCGTTAAGCCTATCTACGACACGAT CAGAGCTGAGATTAATGAGAGCAAGAACGGGACGGAGCCGCATTGTAAGT GGAGGAACTACGATGATATTAATGAGTACTTCTGGACGGATAGGTGTTTT AGTAAATTGAAATGGCCGATTGATTTGGGGAGCAGTTTCTTCAAGAACAG CAGAGGTAGCGGAGTTGGGAAGACAGGTTTTGTGGAGAGGAGGACGTTTT TCTACCTCTACAGGAGCTTTGATAGGCTTTGGGTGATGCTTGCTTTGTTT CTTCAAGCTGCTATTATAGTTGCTTGGGAGGAGAAGCCGGGTGGAGGGTC GGTGACGAGTCAGCTCTGGAATGCGTTGAAGTCGACGGATGTTCAGGTGA GGCTTTTGACTGTTTTCTTGACGTGGAGTGGGATGAGGTTGTTGCAGGCT GTGCTGGACGCTGGCTCGCAACGGTCGCTTATTTCTAGAGAGACCAAACG GCTGTTTTTCAGAATGTTGATGAAGGTTGTGGCTGCTACGGTTTGGATAA TAGCGTTTATTGTTCTCTACACGAACATCTGGAAGCAGAGGAAGCAAGAT AGGCAGTGGTCCAGAGCCGCGAATGATAAGATCTATCAGTTCCTTTACGC TGTGGTGGCTTTCTTGGTCCCTGAGATCCTGGCTTTGGCTCTGTTTATAG TCCCGTGGATAAGGAACTTTCTGGAAGAGACCAATTGGAAGATATTCTTT GCTTTGACTTGGTGGTTCCAGGGGAAAAGCTTTGTGGGTCGAGGTTTGAG AGAGGGGTTGGTGGACAACATCAAGTACTCGACTTTCTGGATCTTTGTCC TCGCAACGAAGTTCACGTTCAGCTACTTCCTTCAGGTTAAGCCAATGATT AAACCCTCGAAGCTGCTATGGAATTTGAAGGAGGTGGATTATGAGTGGCA TCAGTTCTTTGGCGAGAGCAATAGGTTTTCTGTCTTGTTATTGTGGCTGC CAGTGGTGTTGATATACCTGATGGATATCCAAATTTGGTACGCGATCTAT TCTTCGATTGTCGGTGCTGTTGTTGGGCTGTTTGATCATCTGGGGGAGAT CAGGGACATGGGACAGCTTAGGCTGAGGTTCCAGTTCTTTGCTAGCGCTA TTCAGTTCAACCTAATGCCTGAGGAACAACTCCTGAATGCTAGAGGATTT GGTAACAAGCTTAAGGACGCCATTCATAGGTAAGTCTATTGAAGCATGTT ACTGATATTCCTCCTATATAATTTACTATACAGAGTTTGTCTTTACAGTA CAAGCTATAGGATTTTAGTTTTGTTAAAGCAGATTCTCCGCAATGAACTA GACTTTTTCACATTGTAATAACATTGAGTTTGTGTACTTTATGCAGATTG AAGCTGAGGTATGGATTGGGGCGGCCGTTTAAGAAACTCGAGTCCAATCA GGTTGAGGCTAACAAGTTTGCGCTGATCTGGAATGAGATAATCTTAGCTT TCAGAGAGGAGGATATAGTCTCTGATCGAGAAGTAGAGCTGCTGGAGCTG CCAAAGAATTCCTGGAATGTAACAGTTATCCGCTGGCCGTGTTTCCTGTT GTGCAATGAGCTTTTGCTTGCACTGAGCCAGGCGAAAGAGCTGGTTGACG CACCTGATAAATGGCTGTGGCACAAGATATGCAAGAATGAGTACAGGCGG TGTGCTGTGGTTGAGGCATATGAAAGCATCAAACATCTGTTGCTTTCAAT CATCAAAATTGACACTGAAGAACATAAAATTGTTACAATTTTCTTTCAGA TGATTGAGGTCTCTATTCAGGGTGAGCAGTTCACCAAGACCTTCAAAGTG GACCTTTTGCCAAAGATTTATGAGACACTACAGAAGTTGGTTGGTCTGTT GAATGATGAGAAAGTGGATGTTGGGCGAGTGGTGAATGGTCTGCAATCTA TTTATGAGATTGCAACACGACAGTTCTTCATAGAAAAGAAGACGACTGAA CAGCTATCTACTGAGGGGTTAACTCCTCATGATCCAGCCTCAAAGTTACT GTTTCAGAATGCTGTTAGGCTTCCCGATGCAAGCAATGAAGACTTCTTCC GGCAGGTTAGGCGGTTACACACAATTCTCACTTCTAGGGACTCTATGCAC AGCGTCCCTGTGAATCTAGAGGCGAGACGGCGGATTGCCTTCTTCAGCAA TTCGCTCTTCATGAACTTGCCTCATGCACCTCAGGTGGAGAAAATGTTGG CGTTCAGTGTTATGACTCCATACTACAGCGAGGAAGTTGTATACAGCAAA GAACAGCTCCGAAATGAGACTGAGGATGGAATTTCAACCTTGTATTACCT GCAGACGATTTATGCCGACGAATGGAAAAATTTTAAGGAACGGATGCGTA GGGAAGGTATAAAGACAGATGTTGAGTTGTGGACAACCAAGCTGAGAGAG CTCAGGCTTTGGGCTTCCTACAGAGGTCAGACTTTGGCACGTACAGTTCG AGGAATGATGTACTATTACAGGGCTCTTAAGATGCTTGCTTTTCTTGACT CTGCGTCTGAAATGGACATTCGGGAGGATGCTCAGGAGCTTGGTTCAATG AGGAGTTCGCAGGGAAATCGATTGGATGGGGTTGACGATGTAAATGACGG ATCTTCTCTAAGCAGAGCAACTAGCTCTGTGAGCATGCTGTATAAAGGCC ATGAGCATGGGACTGCATTGATGAAATTCACATATGTCGTGGCGTGCCAG ATCTATGGGTCTCAAAAAGCGAAGAAGGAGCCTCAGGCAGAGGAAATTCT GTATCTTATGAAGCAAAACGAAGCCCTCCGTATTGCATATGTGGATGAGG TACATGCGGGCAGGGGAGAGACTGAGTATTACTCCGTTCTGGTGAAATAC GATCATACGTTGGAGAGGGAAGTGGAGATATTCCGTGTGAAGCTACCTGG TCCGGTGAAGCTGGGTGAGGGAAAGCCAGAGAACCAGAATCATGCAATGA TCTTTACCCGTGGTGATGCTGTTCAGACCATAGATATGAACCAGGATAAT TATTTTGAGGAGGCTCTCAAGATGAGAAATTTGCTCCAGGAGTTTAGGCA TTATCATGGGATCAGAAAACCAACTATTCTTGGTGTCCGGGAGCACATCT TCACGGGATCTGTCTCGTCTCTGGCATGGTTCATGTCTGCTCAGGAGACT AGTTTCGTCACTCTTGGTCAGCGTGTTCTCGCCAATCCGCTGAAGGTCAG AATGCATTATGGTCATCCTGATGTTTTTGACAGATTCTGGTTCTTGAGTC GAGGTGGCATCAGCAAAGCTTCTAGAGTTATAAATATCAGTGAGGACATC TTCGCCGGGTTTAATTGCACATTGCGGGGCGGTAACGTCACCCACCACGA GTATATTCAGGTAGGGAAATGTTCATCATTTGGATATTCTAACTAATTTA TACATCGACAACAATACTATAATTCCACTTTTTTTGTTATAACCTTCGTG TGTGTGCATATGTATTCAGGTTGGGAAGGGTCGAGATGTTGGATTGAATC AAATATCAATGTTTGAGGCTAAGGTAGCCAGTGGGAATGGAGAGCAGGTT CTTAGCCGAGATGTGTACAGGCTGGGTCATAGGCTCGATTTCTTCAGAAT GTTATCATTTTTCTACACAACGGTGGGGTTTTTCTTCAACACGATGATGG TCATTCTCACTGTCTACGCTTTCCTCTGGGGTCGGGTTTATCTTGCTCTG AGCGGTGTTGAGAAGTCCGCTCTAGCAGACAGCACAGACACCAACGCAGC GCTTGCTGTGATATTGAACCAGCAATTCATCATTCAGCTTGGTCTCTTCA CAGCTCTGCCAATGATTGTGGAATGGTCTCTCGAGGAGGGTTTCCTTCTA GCGATATGGAATTTCATTCGGATGCAGATTCAGCTTTCATCTGTCTTCTA CACATTCTCAATGGGGACCAGAGCTCACTATTTTGGCCGAACCATTCTCC ATGGTGGAGCAAAGTACAGAGCCACTGGGCGTGGATTTGTTGTCGAGCAC AAGAGCTTCACTGAGAATTACCGTCTATACGCACGCAGTCACTTTGTGAA GGCCATCGAGCTTGGGCTGATCCTCATAGTCTACGCTACGCACAGTCCCA TCGCCAAAGACTCATTGATCTATATAGCTATGACTCTCACCAGCTGGTTC CTCGTGATTTCATGGATACTGGCCCCTTTTGTGTTCAACCCGTCAGGATT CGACTGGCTTAAGACGGTCTATGACTTCGAAGGCTTCATGAACTGGATCT GGTATCAAGGCAGAATCTCAACGAAGTCCGAACAGAGCTGGGAGATATGG TGGTATGAGGAACAGGACCACCTGAGAACCACCGGTATACCAGGAAGAAT CGTGGAGATAATCTTGGACCTTCGGTTTTTCTTCTTCCAGTACGGGATTG TATACCAGCTCAAAATCGCAAACGGATCAACCAGCATTCTCGTCTACTTA CTCTCATGGATATACATCTTCGCAGTGTTTGTGTTCTTCCTAGTAATCCA ATACGCCCGTGACAAGTACTCAGCGAGAAACCACATACGGTACAGGCTCG TCCAGTTCCTCCTGATCGTGTTTGGTACACTGGTGATTGTTGCTCTCCTC GAGTTCACGCATTTCAGCTTCGTGGATATCTTCACGAGTCTTCTTGCGTT CGTCCCAACCGGCTGGGGAATCTTGCTGATCGCACAGGCTTTGAGGCCTG CGCTGCAGAAGATCGGGCTTATCTGGAACGCGGTTGTCTCCCTTGCTCGG TTGTATGACATACTGTTCGGGATAGTCATCATGGTTCCCGTAGCGTTCAT GTCGTGGATGCCTGGGTTTCAATCGATGCAAACGAGGATCTTATTCAATG AAGCTTTTAGCAGAGGGCTTCGTATCATGCAGATTGTCACTGGGAAGAAA TCAAAAGGCGATGTCGAAGTTGAAAAAAGAAGGTAAAGCTTCTTATTTAC CCAAACATCTTTTATGTTCTGTTTGTTTGGAATCTTAAATTACAACAACA CTAATGCAAAGCTTTTATAACTTGTGTAGGTCTTGAGGTATATGGTAATT TAAAAGTTGCTGGTTTGCGGCGATGAGGTTAGTTTTGTATTCTTATAAGT TATGCTTCTTGTCTGAATAAGAACTCAGACACCCGTGTTTTGTCTTCTTC TTATTTTAAACCAGGTTTTTGGAGAGCTTTGGTTGAGGAAGCTATTTGAT TAGTTCATCGGTTAGTGGGAGAAACATATATATACATTTGTCAGTACTTT GTTAGAGTGTGTGGAAATGGGGACGACTCTGATTCTGATTCCTTATGTGG TTATTGTCTGAAACGTTACAGCATTTTGTGAAGTAGGCTTTTGTGCAAGA TTTGATATCTTTCTCTCATTGTAGAGCTTTAGAGCATTTTTTAGTATATG TTTAATCTTTGATTTTTCTAATGTCATTTGCATTCATATTTCAC SEQIDNO.5 GTTTCTTTTTTTTTTTGGTCGAAATTATATTATTGTTTCTCTGAGCTGTT ACCATTACATTAACAATTTACATTCTATCCTTTTGATGAAAAATATTATA AAATGTTAAAAGAAGTTATTAGAAAAGGAGAGGAAAACAGGGGGAGAGCA TGGAGGGGTCCCATGTGTGTTTCGGAAAGCAGCAAACATGACTTTGTAAA GTCTTGTTTTAGCGTCCAAAGCGGTCTCACTCGCCGTTCAGCGAGCTTTA GCTGTTAAATTTTCTTGAAATAAATCGCTCCACTTGTTAAAAAAAAAAAT GATAACTGTGTCCATTTCGACTAATATCTATTTTGTGTCATTTTTGCATA TAATATTTTTTAATATTTTTGAAAATAAATTTAATAAATAGTTTTATAAA CAAAAAAAATTGAAAAATAGTAACTATTGATAAAATACCTATATGAACTT AGTAGTATTTTTTTTCAGTTCTAAAAATGTTTAAATCATAATTTTCAGAT TATGTTATAAATAAAGCAGAAATGACATTCTACGAAGTAGAAAACGAAAT CCATTTTTTTTCATTGAATCTACAATGTTTAGAATACGAAATCTTCGTAA ATAAGAGTATTCTAAAAATATTTAGAATACACATTCCGCGCTTAACCTAC CGATCTAAAATCTTTAGAAATCAAAATCTACAGATTAATATAAATCTAAA ACACGTTGAAACCGACTTCTACAGATTTACTGTAAATCTAAAACATGTAG AAATCAAAATTCTACACATTACTATAATTCTAAAAACCTATAGAAACCGA TTTCTACATATTATCTGTATTCTACGGATAAGAAATCAGTTCTTAAAAAT ATGGAAACAAAATATTTGAGAATATTCACTTTCATATTTTGAAAAAAATC GATTTAAAAAAAACAAAAAAAACAAAAAACCTTCTTTTCACGCCGTCTTC TATATTCCATTGATTGTTCACAAAATTTTCACATTATTTCCACCATATCA GTGTGAAATTGAGTGAGTTAGGGTTTATGAACTTGAGACTTTGATTTTCT CCCTTTTTGTTCGTGAAGGAGATGAGAAATTATGAGTTTCATCTCAAAGA AATCGAGTTTAAAGAGTTGAAATCGTGTTTGGTCGGTTCAAATCAAGTGG GAATTAAACCGGATATAACCGAAGAAAACCAGGAAATCGATTTGGAATAC TTACCTAGGCACAAGATCGATCGGTCTATAATTAGAGATCGGTTGATCTG TATGAAATCGACTTTTGCCGATCGAGTGAAATGGACCAGGTCGATCAGCC GCGTTTTTTTGTTCTGCATAATGATCAGAATCGGTCAATCCGTCCGACCT TGTAATTTCGGATCGATCGATCCCGCTTGATCGAACCTATTATTTATTAT ATTTAAGAATTACAATTTTAAGGATTTTATTGCCATTTTGAAAATAATTA GTCTAATTGAACATAAAATATATAAGATTAGTCTAAAATGACATAGTTAT CATTTTTTGTTCTAAAAAAACAATTTCCCTTTTTTATTTTTGTTTCTTTC AACACACTTGTATTAATAACAATAATGATATTGCTAATCTTGAACAAATC GTGGATTGTCTTTTCTTCCGGTGATATCATCCTTAGTCAAAACATCTCAA ATTAAATAAGTATAGAGTTGTGAATGTTTTTAAAAGTTTGGCGTTTGTAT AGATCACTGTCAGTGTCATGAATCATTAGGTGACTGCAAATTTTTATATG ACAAAAAAGAGAGTTGATACTTGCCATTCTCGAGATTTTGAAGTTTTTTT CGTCGTCAACATACAAACTCAACATTTTCGAAATCTTGGATTAAAAATAA AAATATGGACAAAACGATACTTATTAATTAATTATGTACTAGCGTCTTAA CATTATTAATATAGATATAATTATAAGAACAAGAAACATAAACATATATG CACAAAGCCTCAAAGCAAATTTAAATAATGTTACAAAACAAGGGATGTAC TTGTTATGAAAAATTAATATATAACCATTCTTAACATATTTTTACGTAAA CCTTAAACTTTATAAAGAAAAATATGTAACATTCCGGTGCGTGGTATATA GAAATATTTTTAAAAATTGATTTGACTATTTCCATTAGCAAAATGCATTT ATTTTTTCGATCATACATTTATTTAAAATTTCAGGGTTAAACGTGATTAA AATGGAGTAATAAGAATATGGATGATCTACCAGAAAATCATTTACGTTTT AAGTGAGACCAAAATACGGATAAAAATCATGTGATGATTGTATGGTTATT AAACAATTATTTTGAATTTGAAAATAATTAACTCATCAAATTAAACCTAA GGACCGAGTAAGCGGACGCAGATAGCCGTAAGCGGTTGGGCCGTCACAAA ATTTATGACCAACAAGAAAATGAAACTGATTTTAGTGGATGATATATTTT AGAAAGTAATAAAATGGTTCCAGATTTCAATACTTCAATGGTTTTTTTAT GCTGACTTTCTTTTCCTCTTTTACTTACATGATAAGGAAACGAGAGAGGT TGAAGAAACAAAGAAAATTCCTAAGGATTTAGAAATGTATCTTCAAAAAA TCTAAGTATTTACCAAGTAAAATCATACAAAATAAGGAAAAAAAAAGAAT TTATTTCCCAATTTGGTTTTTACCGGAAAAAAAATTGTTTTAATAAAATC TTATGCACCAAATCATATAAGAACGAACCATAACAAACTTTATTTGACCA TTGTCATTAGTTTATTTTATTTATGGTAATGGATCTTCAAATAATTTGAA TTAAATTAAAAAAAAGAATAAAAAAAGAGAAACAAAAACGCGGAAAGGAG AGCCCAAATCGTCTCCGTCTGTCATTGTCGCAGTCTCTCACAGCTAAATA AAAGAGAAAAACAAATCGCAACGCTTCAATATCTCTCTCCCAATCGTTTG AATTAGTCTTCCTCATCACAATACCCCTAAGATCCACCTCACATGCTACT ATGAGCCTCCGCCACCGCACCACCGTCCCCTCTCAACCCGGACGGCCCCC GGCGGCGGGCGCAATCGACGAGGAGCCCTACAACATCATCCCCGTCAACA ACCTCCTCGCCGACCACCCCTCCCTCCGCTACCCCGAGGTCCGCGCCGCC GCCGCCGCCCTCAAAACCGTCGGAGACCTCCGCCGCCCCACCTACGTCCA ATGGCGCCCCCACTACGACCTCCTCGACTGGCTCGCCCTCTTCTTCGGCT TCCAGAAGGACAACGTCCGCAACCAGCGCGAGCACCTCGTCCTACACCTC GCCAACGCCCAGATGCGCCTCACGCCGCCGCCGGATAACATCGATTCCCT CGATCCCGCCGTCGTCCGCCGTTTCCGCCGCAAGCTCCTCGGTAACTACT CGAGCTGGTGCTCGTACCTCGGGAGGAAGTCGAACATCTGGATCTCGGAT CGGAACCCCGATTCGAGGCGGGAGCTTCTCTACGTCGGCCTCTACCTCCT CGTGTGGGGGGAGGCGGCGAATCTTAGGTTTATGCCGGAGTGTATCTGTT ACATCTTCCACAATATGGCCTCGGAGCTTAACAAGATCCTCGAGGATTGC CTCGACGAGAGCACGGGGCAGCCGTATTCTCCTAGAATCACGGGGGAGAA TAGTTTCCTAAACGGCGTCGTTAAACCTATTTACGAGACGATCAAAGCTG AGATTAACGAGAGCAAGAACGGGACGGAGCCGCATTGTAAGTGGAGGAAC TATGATGATATTAACGAGTACTTTTGGACGGATAGGTGTTTCAGTAAATT GAAATGGCCGATTGATTTGGGGAGCAGTTTCTTCAAGAGTAGTAGAGGGA GCGGCGTTGGGAAGACAGGTTTTGTGGAGCGGAGGACGTTTTTTTACCTC TACAGGAGCTTTGATAGGCTTTGGGTGATGCTTGCTTTGTTTCTTCAAGC TGCTATTATAGTTGCTTGGGAGGAGAAGCCGGGTGGAGGGTCGGTGAGGA GTCAGCTCTGGAATGCGTTGAAGTCGACGGATGTTCAGGTGAGGCTTTTG ACTGTGTTTTTGACGTGGAGTGGGATGAGATTACTGCAGGCTGTGCTGGA CGCTGGCTCGCAACGGCCGCTTATTTCTAGAGAGACCAAACGGCTGTTTT TCAGAATGCTGATGAAGGTTGTAGCTGCTACGGTTTGGATCATTGCTTTT ATTGTTCTCTACACGAACATCTGGAAGCAGAGGAAGCAAGACAGGCAGTG GTCCAGAGCCGCGAATGACAAGATCTACCAGTTCCTTTACGCTGTGGTGG CTTTCTTGGTCCCTGAGATCCTGGCTTTGGCTCTGTTTATAGTCCCGTGG ATAAGGAACTTTCTGGAAGAGACCAATTGGAAGATATTCTTTGCTTTGAC TTGGTGGTTCCAGGGTAAAAGCTTTGTGGGTCGAGGTTTGAGAGAGGGGT TGGTGGACAACATCAAGTACTCGACTTTCTGGATCTTTGTCCTAGCAACG AAGTTCACGTTCAGCTACTTCCTGCAGGTTAAGCCAATGATTAAACCCTC GAAGCTGCTATGGAATTTGAAGGAGGTGGATTATGAGTGGCATCAGTTCT TTGGCAAGAGCAATAGGTTTTCTGTCTTGTTATTGTGGCTGCCAGTGGTG TTGATATACCTGATGGATATCCAAATTTGGTACGCGATCTATTCTTCGAT TGTTGGTGCTGTTGTTGGGCTGTTTGATCATCTGGGGGAGATCAGGGACA TGGGACAGCTTAGGCTGAGGTTTCAGTTCTTTGCTAGCGCTATTCAGTTC AACCTAATGCCTGAGGAACAACTCCTGAATGCTAGAGGATTTGGTAACAA GCTTAAGGACGCCATTCATAGGTAAGTCTATTGAAGCATGTTACTGATAT TTCTATATAATTTATTATACAGAGTTTGTCTTTACAGTACAAGCTATAGG ATTTTAGTTTTGTTAAAGAAGATTTCTCCGCAATGAACTCGACTTTTCAC ATTGTAATAACATTGAGTTTGTGTACTTTATGCAGATTGAAGCTGAGGTA TGGATTGGGGCGGCCGTTTAAGAAACTCGAGTCCAATCAGGTTGAGGCTA ACAAGTTTGCGCTGATCTGGAATGAGATAATCTTAGCTTTCAGAGAGGAG GATATAGTCTCTGATCGAGAAGTAGAGCTGCTGGAGCTGCCAAAGAATTC CTGGAATGTGACAGTTATCCGCTGGCCGTGTTTCCTGTTGTGCAACGAGC TTTTGCTTGCACTGAGCCAGGCGAAAGAGCTGGTTGACGCACCTGATAAA TGGCTGTGGCACAAGATATGCAAGAATGAGTACAGGCGGTGTGCTGTGGT TGAGGCATATGAAAGCATCAAACATCTGTTGCTCTCAATCATCAAAATTG ACACCGAAGAACATAAAATTGTTACAATTTTCTTTCAGATGATTGAGGTG TCTATTCAGGGTGAGCAGTTCACCAAGACCTTCAAAGTGGACCTATTGCC AAAGATTTATGAGACGCTACAGAAGTTGGTTGGGCTGTTGAATGATGAGA AAGTGGATGTTGGGCGAGTGGTGAATGGTCTGCAGTCTATTTATGAGATT GCAACACGACAGTTCTTCATAGAAAAGAAGACGACTGAACAGCTATCTAC CGAGGGGTTAACTCCTCATGATCCAGCCTCAAAGTTACTGTTTCAGAATG CTGTTAGGCTTCCCGATGCAAGCAATGAAGACTTCTTCCGGCAGGTTAGG CGGTTACACACAATTCTCACTTCTAGGGACTCTATGCACAGCGTCCCTGT GAATCTAGAGGCGAGACGGCGGATTGCCTTCTTCAGCAATTCGCTCTTCA TGAACTTGCCTCATGCACCTCAGGTGGAGAAAATGTTGGCGTTCAGTGTT ATGACTCCATACTACAGCGAGGAAGTTGTATACAGTAAAGAACAGCTCCG AAATGAGACTGAGGATGGGATTTCAACCTTGTATTACCTGCAGACGATTT ATGCCGACGAATGGAAAAATTTTAAGGAACGGATGCGTAGGGAAGGTATA AAGACAGATGTTGAGTTGTGGACAACCAAGCTGAGAGAGCTCAGGCTTTG GGCTTCCTACAGAGGTCAGACTTTGGCACGTACAGTTCGAGGAATGATGT ACTATTACAGGGCTCTTAAGATGCTTGCTTTTCTCGACTCTGCGTCTGAA ATGGACATTCGGGAGGATGCTCAGGAGCTTGGTTCAATGAGGAGTTCGCA GGGAAATCGATTGGATGGTGTTGACGATGTAAATGACCGATCTTCTCTAA GCAGAGCAACTAGCTCTGTGAGCATGCTGTATAAAGGCCATGAGTATGGG ACTGCATTGATGAAATTCACATATGTCGTGGCGTGCCAAATCTATGGGTC TCAAAAAGCGAAGAAAGAGCCTCAGGCAGAGGAAATTCTGTATCTTATGA AGCAAAACGAAGCCCTTCGTATTGCATATGTGGATGAGGTACATGCGGGC AGGGGAGAGACTGAGTATTACTCCGTTCTGGTGAAATACGATCACACGTT GGAGAGGGAAGTGGAGATATTCCGTGTGAAGCTACCTGGTCCGGTGAAGC TGGGTGAGGGAAAGCCAGAGAACCAGAATCATGCAATGATCTTTACCCGT GGTGATGCTGTTCAGACCATAGATATGAACCAGGATAATTATTTTGAGGA GGCTCTCAAGATGAGAAATTTGCTCCAGGAGTTTAGGCATTATCATGGGA TCAGAAAACCAACTATTCTTGGTGTCAGAGAGCACATCTTCACGGGTTCT GTCTCGTCTCTGGCTTGGTTCATGTCTGCTCAGGAGACAAGTTTCGTCAC TCTTGGTCAGCGTGTTCTAGCCAACCCGCTGAAGGTCAGAATGCATTATG GTCACCCTGATGTATTTGACAGATTCTGGTTCTTGAGTCGAGGTGGCATC AGCAAAGCTTCTAGAGTTATAAATATCAGTGAGGACATCTTCGCCGGGTT TAATTGCACATTGCGGGGCGGTAACGTCACCCACCACGAGTATATTCAGG TAGGGAAATGTTCATCATTTGGATATTCTAACTAATTTATACATCGACAA CAATACTATAATTCCACTTTTTTGTTATAACCTTTTTGTGTGTGCATATG TATTCAGGTTGGGAAGGGTCGAGATGTTGGATTGAATCAAATATCAATGT TTGAGGCTAAGGTAGCCAGTGGGAATGGAGAGCAGGTTCTTAGCCGAGAT GTGTACAGGTTGGGTCATAGGCTCGATTTCTTCAGAATGTTATCATTTTT CTACACAACGGTGGGGTTTTTCTTCAACACGATGATGGTCATTCTCACTG TCTACGCTTTCCTCTGGGGCCGGGTTTATCTTGCTCTGAGCGGTGTTGAG AAGTCCGCTCTAGCAGACAGCACAGACACCAACGCAGCGCTTGCTGTGAT ATTGAACCAGCAGTTCATCATTCAGCTTGGTCTCTTCACAGCTCTGCCAA TGATTGTGGAATGGTCTCTCGAGGAGGGTTTCCTTCTCGCGATATGGAAC TTCATTCGGATGCAGATTCAGCTTTCTTCTGTCTTCTACACATTCTCAAT GGGGACCAGAGCTCACTATTTTGGCCGAACCATTCTCCACGGTGGAGCAA AGTACAGAGCCACTGGACGTGGATTTGTTGTCGAGCACAAGAGTTTCACT GAAAACTACCGTCTATACGCGCGCAGTCACTTTGTGAAGGCCATCGAGCT TGGGCTGATCCTCATAGTCTACGCTACGCACAGTCCCATCGCCAAAGACT CATTGATCTATATAGCCATGACTCTCACCAGCTGGTTCCTCGTGATTTCA TGGATACTAGCCCCTTTTGTGTTCAACCCGTCAGGTTTCGACTGGCTTAA GACGGTCTACGACTTCGAAGGCTTCATGAACTGGATCTGGTATCAAGGCA GAATCTCAACGAAGTCCGAACAGAGCTGGGAGATATGGTGGTATGAGGAA CAGGACCACCTGAGAACCACCGGTCTACCAGGAAGAATCATGGAGATAAT CTTGGACCTTCGGTTTTTCTTCTTCCAGTACGGGATTGTATACCAGCTCA AAATCGCAAACGGATCAACCAGCGTTCTCGTCTACTTACTCTCATGGATA TACATCTTCGCAGTGTTTGTGTTCTTCCTGGTAATCCAATACGCCCGTGA CAAGTACTCAGCGAGAAACCACATACGGTACAGGCTCGTTCAGTTCCTCC TGATCGTGTTTGGTACACTGGTGATTGTTGCTCTCCTGGAGTTCACGCAT TTCAGCTTCGTGGATATCTTCACGAGTCTTCTTGCGTTCGTCCCAACCGG CTGGGGAATCTTGCTGATCGCACAGGCTTTGAGGCCTGCGCTGCAGAAGA TCGGGCTTATCTGGAACGCGGTTATCTCCCTTGCTCGGTTATATGACATA CTGTTCGGGATAGTCATCATGGTCCCCGTAGCGTTCATGTCGTGGATGCC TGGGTTTCAGTCGATGCAAACGAGGATCTTATTCAATGAAGCTTTTAGCA GAGGGCTTCGTATCATGCAGATTGTCACTGGGAAGAAATCAAAAGGCGAT GTCGAAGTTGAAAAAAGAAGGTAA SEQIDNO.6 CTGTCAGATTTAGTTTCACAAAATCTTTGTAACTTCGCGGTTTTTGATAT GGAAGTTGCTACAAAAACTGACTTGTGATATTATAATCTTTCGGCAAGAA AAATATATAATACTAATTTCAGAAAGTATTCTGTTGAATTGTTGATCACC AAATACACATAAACCGGCAGATGTTGACATGTTTACGTGGGATCACTGGG ATAGAAGTTTTGCTTCTGTATTAGTATCGCGAACCGGTTTGTAGTAGCGA AAATAACATTATTATTTTCAGATTTCATCATCGTCAAATTCAACGTTACA TTTGAACAGGCTTGTAAAAAGTGGACATGTGGCATGAGTAAAAGATAAAG AAAATTGTGAGCCTTTTTGTTAATACGAAAAAGCCGAAAACGTTATTATT TCTATCATCGGCAAATTTAATGTTAAATTTGCTCCACATCATTCAGAGGG TATATGTATATTTTTCTAATGCTTCGGTGAAGCACATGCGACCATTTGTT GCGTCAGAAGTCAGAACAAAAGGAAGATTCCATCTAATGGATTATAATCC CACATGCCCATTTTTAAAACTAGACAAAATAACTTATAATAGTCCCATAA GAGCATTAAGACAAACTGAACCAAAAAGAATCTTAAATGCTGGTGAATCT AGTCTCGAATGCTGCTGAACACTCCTGATATTAGAATTTGGCAGAAAATA TTCATACTAATAACAGTAAATACATTTCAAAACAAGAAAATAGTAGTAGT AAATAAAAACAATTAATATGTTATTATTGTTTCTCTTAGCTGTTACCATT ACATTAACAATTTACATTCAATCCTTTTAATGAAAAATATTATAAAATAT TAAAAGAAGTTATTAGAAAAGGAGAGGGATATGGGGGGGGGAGAGCATGG AGGGGTCCCATGTGTGTTTCGAAAAGCAGCAAACATGACTTTGTAAAGTC TTGTTTTAGCTAGAGTTCCAAAAAAAAAAGAGTTCAAAAAAAAAGAAAAA AAAAAGTCTTGTTTTAGCGTCCAAAGCGGTCTCACTCGCCGTTCAGCTGT TAAATTTTCTTGAAATAAATCGCTCCACTTGTTTTTTATTTTTGTTTCTT TCAACCCACTTGTATTAATAACAATAATGATATTGCTAATCTTGAACAAA TCGTGGATTGTCTTTTCTTCCAGTGATATCATCCTTAGTCAAAACATCTC AAATTAAATAAATATATAGTTGTGAATTAAAAAAAAGGTATAGAGTTTAT AAAATTAGCATTTGCGAATGTTTTTAAAAGTTTGGCGTTTGTATAGATCA CTGTCAGTGTCATGAATCATTCGGTGACAGCAAATTTGTATATGCCAAAA AAGAGAGTTGATACTTGCCATTCTCGATATTTTGAATTTTTTTTCGTCGA CATACAAACTCAACATTTTCGAAATCTTAGATTAAAAACAAAATGGACAA AACGATACTTATTAATGAATTATGTACTAGCGTCTGAACATTAGTAACAT AGATATAATTATAAGAACAAGAAACATATATGCACAAAGCCTCAAACCAA ATTTAAATAGTGTTACGAAACAAGGGATGTACTTGTTATGAAAAATTAAT GTATAACCATTCTTAGCATTTTTTACCTAACCCTTAAACTTTATAAAGAA AAATATGTAACATTTCGGTGTGTGGTATATAAAAGTATTTTGAAAATCGA TTTGATTATTTCTATTATTAAAATGTACTTACTTTTTTTATCACACATTT ATTTACAATTTCAGAGTTAAACATGATTAAGACAAAGTAGTGAAAATATA GATGATCTACCAGAAAATCATTTGCTTTCTGAGTGAGATCAAAATAAAGG CAAAAATAATGTGATGATTGTATATTAAACAATTATTTTGAATTTGAAAA GAATAACTCATCGAATGAAGCCTATGAACCGAGTAAGCGGTGAAGCGGTT GGACCGTCACAAAAATTATGACCAACAAGAAAATAAAATTGATATTAGTG AAGGGCAATTGTCAATAATAGCACCTTTTGAAGTTTATGTCTCAAAAATA GCACTAGAAGGAGAAAGTCACAAAAATGACATTCATTAAAGGGTAAAATA TCTATAATACCCTTGGTTTAAAATTAAATAAACAAACTAAAATAAATAAA AATAAAAAAATAAAAAAAATAAAAATAAAAAAAATAAATTTTTTTTTATA GTTTCAGATTATATGTTTTCAGATTCGAAATTTTTATAATTTTTTTTTAA AAAAAAATTTTAAATCTTTTTTTTATTTTTTTTTCAGATTTTATTTTTAT AATTTAAAAATACTTTTTGAAACTGTTTTTAAAATTTTTATTTTTTATTT TATTATTTATTATTTATAAAATTTTAAATCCTAATTCCAAAACCCCACCC CTTAACTCTAAACCCTAATGTTTGGATTAATTAACCCTAGGGGTATAAGT GTACATTACCTCTTTAATGAAACCTATTTTTGTGACTTTGAACCTTGAGT GCTACTTTGGGAACAAAAACTTGGTTTGGTGCTATTCTAGTATTTTTCTC ATTAGTGAATGATATATTTTAGAAAGTAATAAATTGGTTCCAGATTTCAA TACATCAATGTTTTTCTAATGCTGACTTGCTTTTCCTCTTTTTCTTACAT GATAAGGAAACGAGAGAGGTCGAAGAAACAAAGAAACTTCCTAAGCATTT AGCAACGCATCTTCAAAAAATCTAGTATTTACCAAGTAAAATCATACAAA ATAAGGAAAAAAAGAAGAATATATTTCCCAATTTGGTTTTCACCGGAAAA AAAAAACTGTCTTAACAAAATCTTAATGCACCAAATCATATAAGAACTTT ATTTGACCATTGTCATTAGTTTTTTCCTTATGGTAATGGATCTTCAAATA ATTTAAATTAAATTAAAAAAAAAAAGAAAAGAGAAACAAAAACGCGGAAA GGAGAGCCCAAATCGTCTCCGTCTGTCATTGTCGCAGTCTCTAAAAGAGA AAAACAAATCGCAACGCTTCTCTCTCTCTCCCTATCGTTTGAATCAGTCT CTCAAGATCCACCACCACCACACATGCTACTATGAGCCTCCGCCACCGCA CCGTCCCCTCTCAACCCGGACGGCCCCCGGCGGCGGGCGCAATCGAGGAC GAGCCCTACAACATCATCCCCGTCAACAACCTCCTCGCCGACCACCCCTC CCTCCGCTACCCCGAGGTCCGCGCCGCCGCCGCCGCCCTCAAAACCGTCG GCGACCTCCGCCGCCCCACCTACGTCCAATGGCGCCCCCACTACGACCTC CTCGACTGGCTCGCCCTCTTCTTCGGCTTCCAGAAGGACAACGTCCGCAA CCAGCGCGAGCACCTCGTCCTCCACCTCGCCAACGCCCAGATGCGCCTCA CCCCGCCGCCGGACAACATCGATTCCCTCGATCCCGCCGTCGTCCGCCGC TTCCGCCGCAAGCTCCTCGGTAACTACTCCAGCTGGTGCTCCTACCTCGG GAGGAAGTCCAACATCTGGATCTCGGATCGGACCCCCGATTCGCGGCGGG AGCTTCTCTACGTCGGCCTCTACCTCCTCGTGTGGGGCGAGGCGGCGAAT CTTAGGTTTATGCCTGAGTGTATCTGTTACATCTTCCACAATATGGCCTC GGAGCTTAACAAGATCCTCGAGGATTGCCTCGACGAGAGCACGGGGCAGC CGTATTCTCCTAAGATCACGGGGGAGAATAGTTTCCTAAACGGCGTCGTT AAGCCTATCTACGAGACTATTAAAGCTGAGATTAACGAGAGCAAGAACGG GACGGAGCCGCATTGTAAGTGGAGGAACTATGATGATATTAATGAGTACT TTTGGACGGATAGGTGTTTTAGTAAATTGAAATGGCCGATTGATTTGGGG AGCAGTTTCTTCAAGAACAGCAGAGGTAGCGGCGTTGGGAAGACTGGTTT TGTGGAGAGGAGGACGTTTTTTTACCTCTACAGGAGCTTTGATAGGCTTT GGGTGATGCTTGCTTTGTTTCTTCAAGCTGCTATTATAGTTGCTTGGGAG GAGAAGCCGGGTGGAGGGTCGGTGACGAGTCAGCTCTGGAATGCGTTGAA GTCGACGGATGTTCAGGTGAGGCTTTTGACTGTGTTCTTGACGTGGAGTG GGATGAGGTTGTTGCAGGCTGTGTTGGACGCTGGCTCGCAACGGTCGCTT ATTTCTAGAGAGACCAAACGGCTGTTTTTCAGAATGTTGATGAAGGTTGT GGCTGCTACGGTTTGGATAGTAGCGTTTATTGTTCTCTACACGAACATCT GGAAGCAGAGGAAGCAAGATAGGCAGTGGTCCAGAGCCGCGAATGATAAG ATTTATCAGTTCCTTTACGCTGTGGTGGCTTTCTTGGTCCCTGAGATCCT GGCTTTGGCTCTGTTTATAGTCCCGTGGATAAGGAACTTTCTGGAAGAGA CGAATTGGAAGATATTCTTTGCTTTGACTTGGTGGTTCCAGGGGAAAAGC TTTGTGGGTCGAGGTTTGAGAGAGGGGTTGGTGGACAACATCAAGTACTC GACTTTCTGGATCTTTGTCCTTGCAACGAAGTTTACGTTCAGCTACTTCC TGCAGGTTAAGCCAATGATTAAACCCTCGAAGCTGCTATGGAATTTGAAG GAGGTGGATTATGAGTGGCATCAGTTCTTTGGCGAGAGCAATAGGTTTTC TGTCTTGTTATTGTGGCTGCCAATGGTGTTGATATACCTGATGGATATCC AAATTTGGTACGCGATCTATTCTTCGATTGTTGGTGCTGTTGTTGGGCTG TTTGATCATCTGGGGGAGATCAGGGACATGGGACAGCTTAGGCTGAGGTT TCAGTTCTTTGCTAGCGCTATTCAGTTCAACCTAATGCCTGAGGAACAAC TCCTGAATGCTAGAGGATTTGGTAACAAGCTTAAGGACGCCATTCATAGG TAAGTCTATTGAAGCATGTTACTGATATTTCTATATAATTTACTATATAG TTTGTCTTTACAGTACAAGCTATGGGATTTTAGTTTTGTTAAAGCAGATT TCTCCGCAATGAACTCGACTTTTCACATTGTAATAACATTGAGTTTGTGT ACTTTATGCAGATTGAAGCTGAGGTATGGATTGGGGCGGCCGTTTAAGAA ACTCGAGTCCAATCAGGTTGAGGCTAACAAGTTTGCGCTGATCTGGAATG AGATAATCCTAGCTTTCAGAGAGGAGGATATAGTCTCTGATCGAGAAGTA GAGCTGCTGGAGCTGCCAAAAAATTCCTGGAATGTGACAGTTATCCGCTG GCCGTGTTTTCTGTTGTGCAACGAGCTTTTGCTTGCACTGAGCCAGGCGA AAGAGCTGGTTGACGCACCTGATAAATGGCTGTGGCACAAGATATGCAAG AATGAGTACAGGCGGTGTGCTGTGGTTGAGGCATATGAAAGCATCAAACA TCTGTTGCTCTCAATCATCAAAATTGACACCGAAGAACATAAAATTGTTA CAATTTTCTTTCAGATGATTGAGGTGTCTATTCAGGGTGAGCAGTTCACC AAGACCTTCAAAGTGGACCTTTTGCCAAAGATTTATGAGACACTACAGAA GTTGGTTGGGCTGTTGAATGATGAGAAAGTGGATGTTGGGCGAGTGGTGA ATGGTCTGCAGTCTATTTATGAGATTGCAACACGACAGTTCTTCCTAGAA AAGAAGACGACTGAACAGCTATCTACTGAGGGGTTAACTCCTCATGATCC AGCCTCAAAGTTACTGTTTCAGAATGCTGTTAGGCTTCCCGATGCAAGCA ATGAAGACTTCTTCCGGCAGGTTAGGCGGTTACACACAATTCTCACTTCT AGGGACTCTATGCACAGCGTCCCTGTGAATCTAGAGGCGAGACGGCGGAT TGCCTTCTTCAGCAATTCGCTCTTCATGAACTTGCCTCATGCACCTCAGG TGGAGAAAATGTTGGCGTTCAGTGTTATGACTCCATACTACAGCGAGGAA GTTGTATACAGCAAAGAACAGCTCCGAAATGAGACTGAGGATGGGATTTC AACCTTGTATTACCTGCAGACGATTTATGCCGACGAATGGAAAAATTTTA AGGAACGGATGCGGAGGGAAGGTATAAAGACAGATGTTGAGTTGTGGACA ACCAAGCTGAGAGAGCTCAGGCTTTGGGCTTCCTACAGAGGTCAGACTTT GGCACGTACAGTTCGAGGAATGATGTACTATTACAGGGCTCTTAAGATGC TTGCTTTTCTTGACTCTGCGTCTGAAATGGACATTCGGGAGGATGCTCAG GAGCTTGGTTCAATGAGGAGTTCGCAGGGAAATCGATTGGATGGGGTGGA CGATGTAAATGACGGATCTTCTCTAAGCAGAGCAACTAGCTCTGTGAGCA TGCTGTATAAAGGCCATGAGCATGGGACTGCATTGATGAAATTCACATAT GTCGTGGCGTGCCAGATCTATGGGTCTCAAAAAGCGAAGAAGGAGCCTCA GGCCGAGGAAATTCTGTATCTTATGAAGCAAAACGAAGCCCTCCGTATTG CATATGTGGATGAGGTGCATGCGGGCAGGGAAGAGACTGAGTATTACTCC GTTCTGGTGAAATACGATCACACGTTGGAGAAGGAAGTGGAGATATTCCG TGTGAAGCTACCTGGTCCGGTGAAGCTGGGTGAGGGAAAGCCAGAGAACC AGAATCATGCAATGATCTTTACCCGCGGTGATGCTGTTCAGACCATAGAT ATGAACCAGGATAATTATTTTGAGGAGGCTCTCAAGATGAGAAATTTGCT CCAGGAGTTTAGGCATTACCATGGGATCAGAAAGCCAACTATTCTTGGTG TCCGGGAGCACATCTTCACGGGATCTGTCTCGTCTCTGGCTTGGTTCATG TCTGCTCAGGAGACAAGTTTCGTCACTCTTGGTCAGCGTGTTCTAGCCAA CCCGCTGAAGGTCAGAATGCATTATGGTCACCCTGATGTATTTGACAGAT TCTGGTTCTTGAGTCGAGGTGGCATCAGCAAAGCTTCTAGAGTTATAAAT ATCAGTGAGGACATCTTCGCCGGGTTTAATTGCACATTGCGGGGCGGTAA CGTCACCCACCACGAGTATATTCAGGTAGGGAAATGTTCATCATTTGGAT ATTCTAACTAATTTATACATCGACAACAATACTATAATTCCACTTTTTTT TTGTTATAACCTTTTTGTGTGTGCATATATGTATTCAGGTTGGGAAGGGT CGAGATGTTGGATTGAATCAAATATCAATGTTTGAGGCTAAGGTAGCCAG TGGGAATGGAGAGCAGGTTCTTAGCCGAGATGTGTACAGGCTGGGTCATA GGCTCGATTTCTTCAGAATGTTATCATTTTTCTACACAACGGTGGGGTTT TTCTTCAACACGATGATGGTCATTCTCACTGTCTACGCTTTCCTCTGGGG CCGGGTTTATCTTGCTCTGAGCGGTGTTGAGAAGTCCGCTCTAGCAGACA GCACAGACACCAACGCAGCGCTTGCTGTGATATTGAACCAGCAGTTCATC ATTCAGCTTGGTCTCTTCACAGCTCTGCCAATGATTGTGGAATGGTCTCT CGAGGAAGGTTTCCTTCTCGCGATATGGAACTTCATTCGGATGCAGATTC AGCTTTCCTCTGTCTTCTACACATTCTCAATGGGGACCAGAGCTCACTAT TTTGGCCGAACCATTCTCCACGGTGGAGCAAAGTACAGAGCCACTGGACG TGGATTTGTTGTCGAGCACAAGAGTTTCACTGAAAACTACCGTCTATACG CACGCAGTCACTTTGTGAAGGCCATCGAGCTTGGGCTGATCCTCATAGTC TACGCTACGCACAGTCCCATCGCCAAAGACTCATTGATCTACATAGCCAT GACTCTCACCAGCTGGTTCCTCGTGATTTCATGGATACTGGCCCCTTTTG TGTTCAACCCGTCAGGATTCGACTGGCTTAAGACGGTCTATGACTTCGAA GGCTTCATGAACTGGATCTGGTATCAAGGCAGAATCTCAACGAAGTCCGA ACAGAGCTGGGAGATATGGTGGTATGAGGAACAGGACCACCTGAGAACCA CCGGTATACCAGGAAGAATCATGGAGATAATCTTGGACCTTCGGTTTTTC TTCTTCCAGTACGGGATTGTATACCAGCTCAAAATCGCAAACGGATCAAC CAGCATTCTCGTCTACTTACTCTCATGGATATACATCTTTGCAGTGTTTG TGTTCTTCCTAGTGATCCAATACGCCCGTGACAAGTACTCTGCGAGAAAC CACATACGGTACAGGCTCGTCCAGTTCCTCCTGATCGTGTTTGGTACACT GGTGATTGTTGCTCTCCTCGAGTTCACGCATTTCAGCTTCGTGGATATCT TCACGAGTCTTCTTGCGTTCGTCCCAACCGGCTGGGGGATCTTGCTGATC GCACAGGCTTTGAGGCCCGCGCTGCAGAAGATCGGGCTTATCTGGAACGC GGTTATCTCCCTTGCTCGGTTGTATGACATACTGTTCGGGATAATCATCA TGGTTCCCGTAGCGTTCATGTCGTGGATGCCTGGGTTTCAATCGATGCAA ACGAGGATCTTATTCAATGAAGCTTTTAGCAGAGGGCTTCGTATCATGCA GATTGTCACTGGGAAGAAATCAAAAGGCGATGTCGAAGTTGAAAAAAGAA GGTAAAGCTTCTTATTTACCCAAACATATTTTATGTTCTGTTTGTTTGGA ATCTTAAATTACAACAACACTAATGCAAAGCTTTTATAACTTGTGTAGGT CTTGAGGTATATGGTAATTTAAAAGTTGCTGGTTTGCGGCGATGAGGTTA GTTTTGTATTCTTATAAGTTATGCTTCTTGTCTGAATAAGAACTCAGACA CCCGTGTTTTGTCTTCTTCTTATTTTAAACCAGGTTTTTGGAGAGCTTTG GTTGAGGAAGCTATTTGATTAGTTCATCGGTTAGTGGGAGAAACATATAT ATATACATTTGTCAGTACTTTGTTAGAGTGTGTGGAGGTGGGGACGACTC TGATTCTGATTCCTTATGTGGTTATTGTCTGAAACGTTACAGCATTTTGT GAAGTAGGCTTTTGTGCAAGATTTGATATCTTTCTCTCATTGTAGAGCTT TAGAGCATTTTTTAGTATATGTTTAATCTTTGATTTTCTAATGTCATTTG CATTCATATTCACATCTTCTCTGCTTCTTCGTTGTCTGAAACCAGTTTTC AGATGCTTATCCATTGTCCA SEQIDNO.7 TATCATTGTCGCAGTCTCTCTCACAGCTAAAAGGAAAACAGATCGCAACG CTTCAATATCTCTCTCTCTCCATTGTTTTGAATTGAATCAGTCTCCTCAC CCTTCTCCAAGATCCACCACACCACATGCCACTATGAGCCTCCGCCACCG CACCGTCCCATCTCAAACCGGACGGCCGTCGGCGGCGGGAATCGAGGAGG AGCCCTACAACATCATCCCCGTCAACAACCTCCTCGCCGACCATCCTTCT CTCCGTTACCCCGAGGTCCGCGCCGCCGCCGCCGCTCTCAAAACCGTCGG CGACCTCCGCCGTCCTCCCTACGTCCAATGGCGTCCTCACTACGATCTCC TCGACTGGCTCGCCCTCTTCTTCGGCTTCCAGAAGGATAACGTCCGCAAC CAGCGCGAGCACATGGTGCTCCACCTCGCCAACGCTCAGATGCGTCTCAC GCCGCCGCCGGATAACATCGATTCCCTCGATTCGACGGTTGTCCGTCGCT TTCGCCGGAAACTCCTCGGAAACTACTCGAGCTGGTGCTCTTATTTAGGG AAGAAATCGAACATCTGGATCTCGGATCGGAACCCTGATTCGAGGCGGGA GCTTCTCTACGTTGGCCTCTACCTCCTCGTGTGGGGCGAGGCGGCGAATC TTAGGTTTATGCCTGAGTGCATCTGTTACATCTTCCATAACATGGCCTCG GAGCTTAATAAGATTCTGGAAGATTGCCTCGATGAGAACACGGGGCAACC CTATCTGCCTACTCTCTCGGGGGAAAACGCTTTCCTAAACGGCGTCGTTA AACCTATTTACGAAACTATCAAAGCTGAGATTGATGAGAGCAAGAACGGG ACGGAGCCGCATTGTAAGTGGAGGAACTATGATGATATTAATGAGTATTT CTGGACGGATAGGTGTTTCAGTAAATTGAAGTGGCCGCTTGATCTGGGAA GCAGTTTCTTCAAGAGTAGTAGAGGGAAAAGCGTTGGGAAAACCGGTTTT GTGGAGCGCAGGACCTTCTTTTACCTCTACAGGAGCTTTGATAGGCTTTG GGTGATGCTTGCGTTGTTCCTTCAGGCCGCCATTATAATTGCTTGGGAGG AAAAGCCGGATAGAGGGTCGGTGACAGGGCAGCTGTGGAATGCCTTGAAG TCCAGAGATGTCCAGGTGAGGCTTTTGACAGTTTTCTTGACGTGGAGTGG GATGAGACTACTGCAGGCTGTGCTGGACGCTGGTTCGCAACGGTCTCTTA TTTCTAGAGAGACCAAACGGCTCTTTTTCAGAATGTTGATGAAGGTTGTA GCTGCCACAGTTTGGATAATAGCTTTTATTGTACTCTACACGAACATCTG GAAGCAGAGGAAGCAAGACAGACAGTGGTCCAGAGCCGCGAATGACAAGA TCTACCAGTTCCTTTACGCTGTGGTGGCCTTCTTGATCCCTGAGATCCTG GCTCTGGCCCTGTTTATAATCCCGTGGATTAGGAACTTTCTGGAAGAGAG CAATTGGAAAATATTCTTTGCTTTAACTTGGTGGTTCCAGGGTAAAAGCT TTGTGGGTCGAGGTTTGAGAGAGGGTTTGGTGGACAACATCAAGTACTCG ACGTTCTGGATCTTCGTCCTAGCAACAAAGTTCACATTCAGCTACTTCCT ACAGGTTAAGCCAATGATTAAACCCTCGAAGCTGCTGTGGAACTTAAAGG AGGTAGATTATGAGTGGCATCAGTTCTTTGGCGAGAGCAATAGGTTTTCT GTCTTATTATTGTGGCTGCCAGTGGTGTTGATATACCTGATGGATATCCA AATTTGGTACGCAATCTATTCTTCGATTGTTGGTGCTGTTGTTGGGCTGT TTGATCATCTGGGGGAGATCAGGGACATGGGACAGCTTAGGCTGAGGTTT CAGTTCTTTGCTAGCGCTATTCAGTTCAACCTGATGCCTGAGGAACAACT CCTGAATGCTAGAGGCTTTGGTAACAAGCTTAAGGACGCCATCCATAGGT AAGTCTGTGGAAGCATGTTACTGATTTCCTTTAGAGTTTAATGTACAGAG TTTGTCTTTACGGTACAAGCTATATAATTTTAGTTTTGTTATAGCAGATT CTCGTAACTTGACTTTTTAACATTGTTATAACCTTGAGTTTGTGTACTTT ATGCAGATTGAAGCTGAGGTATGGATTTGGGCGGCCGTTTAAGAAACTCG AGTCTAATCAGGTTGAGGCCAACAAGTTTGCTTTGATCTGGAATGAGATA ATCTTAGCTTTTAGAGAAGAGGATATTGTCTCTGATCGAGAAGTAGAGCT ACTGGAGCTGCCAAAGAATTCCTGGAATGTGACAGTTATCCGCTGGCCGT GTTTCCTGCTGTGTAACGAGCTTTTGCTTGCACTGAGCCAGGCGAAAGAG CTGGTTGATGCTCCTGATAAATGGCTGTGGCACAAGATATGCAAGAATGA GTACAGGCGTTGTGCTGTGGTTGAGGCATACGACAGCATCAAACATCTGT TGCTCTCGATCATCAAAATCGACACTGAAGAACATAAAATCATCACGGTT TTCTTTCAGATGATTAAGGTTTCTATTCAGGGAGAGCAGTTCACCAAGAC CTTCAAAGTGGATCTTCTGCCAAAGATTTACGAGACACTACAGAAGTTGG TTGGGCTGTTGAATGGTGAGGAACCGGATATCGGGAGAGTGGTGAATGTT CTGCAGTCTATATATGAGATTGCAACACGACAGTTCTTTATAGAAAAGAA GACAACTGAACAGCTATCTACTGAAGGATTAACTCCTCATGATCCAGCCT CAAAGTTACTGTTTCAGAACGCTGTTAGGCTTCCCGATGCAAGCAATGAA GACTTCTTCCGGCAGGTGAGGCGGTTACACACAATTCTCACTTCTAGGGA CTCTATGCACAGCGTCCCTGTGAATCTAGAGGCGAGACGTCGGATTGCCT TCTTCAGCAATTCGCTCTTCATGAACTTGCCTCATGCACCTCAGGTGGAA AAAATGTTGGCGTTCAGTGTTATGACTCCATACTACAGCGAGGAAGTTGT ATACAGCAAAGAACAGCTCAAAAATGAGACTGAGGACGGGATTTCAACCT TGTATTACCTGCAGACGATTTATGCTGACGAATGGAAAAATTTTAAGGAA CGGATGCGTAGGGAAGGTATAAAGACAGATGATGAGCTGTATACAACCAA GCTGAGAGAGCTCAGGCTTTGGGCTTCCTACAGAGGTCAGACTTTGGCAC GTACAGTTCGAGGGATGATGTACTATTACAGGGCTCTTAAGATGCTTGCT TTTCTTGACTCTGCGTCTGAAATGGACATTCGGGAGGATGCTCAGGAGCT TGGTTCAATGAGGAGTTCGCAGGGAAATCTGGGCGGTCGATCGAATGGGG TTGACGATGTAAATGACCGATCTTCTCTAAGCAGAGCTACTAGCTCCGTG AGCATGCTGTATAAAGGCCATGAGCATGGGACTGCATTGATGAAATTCAC ATATGTCGTGGCGTGCCAGATCTATGGGTCTCAAAAAGCGAAGAAGGAGC CTCAGGCAGAGGAAATTCTCTATCTTATGAAGCAAAATGAAGCCCTCCGT ATTGCGTATGTTGATGAGGTGCATGCAGGCAGGGGAGAGACCGAATATTA CTCAGTTCTGGTGAAATACGATCACACTTTGGAGAAGGAAGTGGAGATAT TCCGTGTGAAGCTACCTGGTCCCGTGAAGCTGGGTGAGGGAAAGCCAGAG AACCAGAATCATGCAATGATCTTTACCCGTGGTGATGCTGTTCAGACCAT AGATATGAACCAGGATAATTATTTTGAGGAGGCTCTCAAGATGAGAAATT TGCTCCAGGAGTTTAGACATTATCATGGGATCAGAAAACCAACTATTCTT GGTGTCCGAGAGCACATCTTCACTGGCTCTGTCTCGTCTCTGGCTTGGTT CATGTCCGCTCAGGAGACTAGTTTCGTCACTCTTGGTCAGCGTGTTCTTG CTAACCCGCTGAAGGTCAGAATGCATTATGGCCACCCCGATGTATTTGAC AGATTCTGGTTCTTGAGTCGAGGTGGCATCAGCAAAGCGTCCAGAGTCAT AAATATCAGTGAGGACATCTTCGCTGGGTTTAACTGCACATTGCGGGGCG GTAACGTCACACACCACGAGTATATTCAGGTTGGTAACTATTCATTATTT GGTTATTTCTAACTAATTTATACTGCGACAGCAATCCTATATTTCCATAT TTCTTTTGTTATAACCATGCAACTTAACGTTCATTGTATCTGAGTGTCAA TGTAAATTTCATAACCCCTGTTTTTGTGCATATATTCAGGTTGGGAAGGG TCGAGATGTTGGATTGAATCAAATATCAATGTTTGAGGCGAAGGTAGCCA GTGGGAACGGAGAGCAGGTTCTTAGCCGAGATGTGTACAGGCTGGGTCAT AGACTCGATTTCTTCAGAATGTTATCATTTTTCTACACAACGGTCGGGTT TTTCTTCAACACGATGATGGTCATTCTTACCGTTTACGCTTTCCTATGGG GCCGGATTTATCTTGCTCTGAGCGGTGTTGAGAAGTCCGCTCTAGCAGAC AGTACAGACACCAACGCAGCGCTTGCGGTTATATTGAACCAGCAGTTCAT CATTCAGCTCGGTCTCTTCACAGCACTGCCAATGATTGTGGAATGGTCTC TCGAGGAAGGTTTCCTTCTTGCGATATGGAATTTCATCCGGATGCAGATT CAGCTTTCTTCTGTCTTCTACACATTCTCAATGGGGACCAGAGCTCACTA TTTTGGCCGAACCATCCTCCACGGTGGAGCAAAGTACAGAGCCACTGGAC GTGGATTTGTTGTCGAGCACAAGAGTTTCACTGAGAACTACAGACTGTAT GCACGCAGTCACTTTGTGAAGGCCATCGAGCTTGGGCTGATCCTCATAGT CTACGCTACGCACAGTCCCATCGCCAAAGACTCATTGATCTATATAGCCA TGACTCTCACCAGCTGGTTCCTCGTGATATCATGGATACTGGCTCCATTT GTGTTCAACCCGTCAGGTTTCGACTGGCTTAAGACGGTCTATGACTTCGA AGGTTTCATGAACTGGATCTGGTATCAAGGCAGAATCTCAACGAAATCCG AACAGAGCTGGGAGATATGGTGGTACGAGGAACAGGACCACCTGAGAACC ACCGGTATACCAGGAAGAATAATGGAGATAATCTTGGACCTTCGGTTTTT CTTCTTCCAGTACGGGATTGTATACCAGCTCAAAATCGCAAACGGATCAA CCAGCATTCTCGTCTACTTGTTGTCGTGGATATACATCTTTGCTGTGTTT GTGTTCTTCCTGGTAATCCAATACGCCCGTGACAAGTACTCTGCGAAAAA CCACATACGGTACAGGCTTGTCCAGTTCCTCCTGATCGTGTTTGGTATTC TGGTGATCGTTGCTCTGCTGGAGTTCACGCATTTCAGCTTCGTGGATATC TTCACGAGTCTTCTTGCGTTCGTCCCAACCGGCTGGGGAATCTTGCTGAT CGCACAGGCTTTAAGGCCTATGCTGCAGAAGTTCAGGCTTATCTGGAACG CTGTTGTCTCCCTTGCTCGGTTATATGACATACTGTTGGGGATACTCATC ATGGTTCCCGTAGCATTCATGTCATGGATGCCTGGGTTTCAGTCAATGCA AACGAGGATCTTATTCAATGAAGCTTTTAGCAGAGGGCTTCGTATCATGC AGATTGTCACTGGGAAGAAATCAAAAGGCGATGTCTAAGTTGAAAATGAA AGAAGGTAAAGCTCTTTATTTACTCAAACATCTTTTATGTTCTGTTTGTT TGGAATCCTAAGATTACAACAAAACCAATGCAAAGCTTTATAACTTGCGT AGGTCATAATAAGGTACATGGTAATTTAAAGTTGTTGGTTTGCGGCGTTG AGATCAGTTGGAGGTTAGTTTTCTCGAGACATGGTATTCTATAAGTTATT GCTTCTTGTCTGAATAAGAACTCAAAAGAAAAACCATGTGTTGTTGTTGT TGTCTTCTTCTTAAAGCAGGTGTTTGGAGAGCTTTTGTTGAGGAATCTGG AAGTTGGGTTAGATCATGGGTTAGCGGGTGAAATATATATTGTCAGTACT TTGTTAGTGTGTGGAAATGGGACTCTGATTCTTGTTGTCTGAAACGATAC AGCATTTTGTGAAGTAGGGCTTTTGTGAAAGATTTGTTTCTCTTTCTCTC TCAGTGTAGAGCTTTAGAGCATTTTTTAGTATATGTTTAATCTTTTTATT TTCTAATGTCATTTGCATTCATATCTCACGTCTTCCTCGTTGGTCTGAAA CCGGTTTTGAGATGCTTATCCATTGTCCACTTCTCTATG SEQIDNO.8 CAAACGATCATAGAAATGTACCTGTAATTAGTCAACTGTTCAAAGAGCTT AATGCATTGCTCCTTATCAATCTGCCCGGTTTTCTGTCATAAACATGAAA TAGAATACAACGTAAACACATATGTTTAGCTATGTGGTAACTAACAGGGA GCTTCCCTGTATATATCTGTAGGAGGTAAAAATCATTTTGAATGGAGTAA CTTACGTCTTTGTCTATAAGACCAAAGGCTTTCTCCAGCATTCTTCTCTT CATTTGATCCATTCCAGATACTTGCTTTGCGAGCTACAAAAATAACAAAT ATGATACCACGCTAGTGCGGTCGTTTTTAGTTTTAACATACAAAAGATCA AGTTTTGCAATAAACCTGTTCTTTGAAACTGTCATAAACAACGGCAAGAA TCAAGTTCGTGACAAAGTAGACGCCAATTAGTACGTAGAGCACGAAGAAC AACGAAGACCAGCGTGAAGACCTATACAAAAAAAAAAAAGAACAAATCAG TCGCCCAAAACACTGGATGTAACTCATTTCACCATATAAACTTACTTGTA AGCACGAATCCAGACATCAGGATTGTTGGATGTTGTGAACAAAATAAACA TCTGGTAAAGAGTTGCACCGTAAGACGTGAAGACCGTGAGTCCTTGTTGT GTATCCTCAAACATAACAAAAGCAATCCAACTGGCAAAGAGAAGGAACAG CATCCATAGAGCCTGTGGAGATATTCAAGAAGTGAAAGCATAGAAGGACA ATCAATACGAGTTCATCACTGTTCTGAAAGTCAAACTCGATTGGGAAGAC CACTGACCAAGATATTCAAGTATGTGCCAAGCATTCCAGAAAGAAGGACG AGGCTGTCTCGAAGTTCCCTGTACAGAAATTTTAAGAAACACAGTTTTTA GACAAGAAGATAATATAAAACAAAAGTGCACTTTCATCGTAAATGGCATT TTGGATTGAGACAAGTTGATAGAAAAGAAGCATAAATATGTGTTGATACC TTATGCTGAGGATGAATATGATAACTCTGACATATGGGGCGATTCTAAAA GGAAGAAAATCGAAAGCCACTGGAGACAAGTATAGAATGTCAACGAGCAC ATCAACAATCAAAACTACCACGCAAGCAACCTGGAATCAGGAAGAAGAAG ACATTTATTGTGTTAAAAGTTATGAAATCAATATCTTAAGTTCTGTCCAA CATTCAACAAATAGAAAAGAAAAAAAAAAGAAACAGTGAAGAAGACTTAT GTAGGGGAGAATACCTTCACTAGGTTAAGGCGGCTTGTCCAAAAGATACG GGACCCTTCATAGGAGATTGGGAAAAAAGTATGTACAAGTAGTATAACCA GGGTAAGTACCTGTTTGGAGAAAGCAAAAATATAAGAATTTCAGTACAAT GAGAAAGGATCCTGGCTAGTCCGAACGATAAGATAACGAGTATATAAATA TTAGCATCTACTTAAACGAGATCAACTAGTTTTCACAAAAGTGTGTAATG AATCTCAAGCCTTGAACTTTCAAGTGGATGCATATAAGAATATGTCAGTA CAGTGAGAAAGGATCCTGGCTAGTCTAGTCCCAACAATATACACCATGGA AGATAAGACGAGTATGTTAATAAAATTAACAACTTCTTAAACGAGATCAA CGAGTCTTGAATCTTTCAAAAGTGGGTTAATATGAATCTGGTGTGCCTAA TTGCACTAAAATCTATTTGCATCTACAGCGAAAATGAAAGGCCAGCTACT TGCCTCAAAGATAATGGATTCTGCATTGGTCAAGTAGGGTAACTCCCCAA GGTAATAGTAATCTCTGTCTTTGCAAGACGGCGTAGGCTTATTTTCACAC CACAATGGTTGCTGCAAAAAGACAGGACAAGAAAGACTGTCACACTTTTT TCTATTTTCTTTTAAAAGTATTTTCTTTTGGGGGGGTTGGGGGGGGGGCA AAAGGTTGCTGACCTCAAAGAAGTTAATCAAAATGAGAGCGAAATAGTTG AGAGACCAGATGAGATCTAATCGTGTGTAGATAAAGTAGTACTTGGCAGA CTCTCCGAAGCTGGACTGGTCAAGTATTTGCTCAGGTAGACCTATACCAT CTTCAGCCTACATACATACAGCAAAATAAATAAATAAATAAATAAAAAGG TTCTCAAAATCAGCAAAAAAGACAAAGAAACCGAACATTTTCTATTGCTA TATTCGTAACTTATTATCAGGTTAAAGAAACAAATCATTTTGAACAAAAA AAAAAAAAAAAGAAACAAATCATATTCTGAGCAATTATTCAGAATAAACG ATTTGGACTTGTCAGACTGATTCTATTCACTGATAAATTGAGAAATCTCC CTCAAGGGAGTTATGCCATCATGTCACAGTCAGTCGGACAAAGATCCATG AATTTTATCAGAACAAGAAGAAGACAAATATAGTTAGGGAGTTGAGAGAT AGAAAGAGAACCAGATCGACGAGAGCAGCAGCTTTCTGAAAGGTGGTACC ATGAGCGATAGCTTCTGATCTACGAACAATCCGATCCGTACCACCACCAC GACTCTCTCTACCTATCAAAGGATCTTCCATTTTTTTTTTCTTCAAAAGG ATCGAAATGGAAAGCAGAAGACCAAGGACCTTATGTAGTACCTTTCTTTC TTTCTTTCTGTCAGTTTATTGTTGGCTACGAATTTTAATATAATGATACA GATCACAAGAAGAAGATAGTGATGATGGCCCAGAAGTAGTTGAATTTTTA AAATAAATTAAATTTTCCAAGTGATATTAGATCTTGCCGACAAACACGTT GGGGTCCCTTTCTCAATTTGTAACTTTGTGGATCAGGATCTAAGTAGATT GGTCAAAACTGAGAGAGTGGTGTTGTGGTCCGAATAAAACTGATTAAAGA ATAAGACTGCAGAGACTAACAAACAGAAGAAACAGATACATAGAGAAGTG GACAATGGAGAAGCATCTCAAAACTGGTTTAACAAGCAGAGAAGAAGATG TGAAATATGAATGCAAAATGACATTAGAAAATCAAAGATTAAACATATAC TAAAAAGAAAGTACTCTAAAGCTCTACAATGAGAGAGAAAGAGAAGAAAT CTGAACACAAAAGCCCTACTTCACACAAAATGCTGTAACGTTTCAGACAA TAACACCATACAAGAATCAGAATCAGAGTCTTCCCCCCTTCCCCCACACT CTAACAAAGTACTGACAAATGTATATATATATGTTTCCCCCACTAACCGA TGCTCTAACCAGATAACCAACTTCCAAATTCGTCCACAAAAGCTCTCCAA AAACCTGTTTCAAGCACAAGACAGAACAAAAGATGGGTTTATTTGAGTTC TTCTTCGCACACCAAGGATAACTTAAAAAAAATTCCATCTCTCGAGAAAA CTAACTAACCTCCAAATGATCACCATCGCCGCAAACCAACAGCTTTTTCA AGTTACCATTTACCATACGACCTACACAAGTTATAAAGCTTCGCATTGGT CTTGTTGTAAATCTTAGGATTCCAAAACAAACAGGATATTAAAGATGTTT CAGTAAATAAAAGAGCTTTACCTTCTTCTTTCTTCAACTTAGACATCGCC TTTTGATTTCTTCCCAGTGACAATCTGCATGATACGAAGCCCTCTGCTAA AGGCTTCATTGAATAAGATCCTTGTTTGCATTGATTGAAACCCAGGCATC CACGACATGAACGCTACGGGAACCATGATGAGTATCCCGAACAGTATGTC ATATACCCTAGCAAGGGAGACAACCGCGTTCCAGATAAGCCTAAACTTCG TCAGCGCTGGCCTTAAAGCCTGTGCGATCAGCAAGATTCCCCATCCGGTT GGGACGAACGCAAGAAGACTCGTGAAGATATCCACGAAGCTGAAATGCGT GAACTCTAGCAGAGCAACAATCACCAGAATACCAAACACGATCAGGAGGA ACTGAACGAGCCTGTACCGTATGTGGTTTCTCGCAGAGTACTTGTCACGG GCGTACTGGATTATCAGGAAGAACACAAACACTGCAAAGATGTATATCCA TGACAACAAGTAGACGAGAATGCTGGTTGATCCGCTTGCGATTTTGAGCT GGTAAACAATCCCGTACTGGAAGAAGAAAAACCGAAGGTCCAAGATTATC TCCACAACTCTTCCTGGTATACCGGTGGTTCTCAGGTGGTCCTGTTCCTC ATACCACCATATCTCCCAGCTCTGTTCCGATTTCGTTGAGATTCTGCCTT GATACCAGATCCAGTTCATGAAGCCTTCGAAGTCATAGACCGTCTTAAGC CAGTCGAATCCTGACGGGTTGAACACAAATGGGGCCAGTATCCATGATAT CACGAGGAACCAACTGGTGAGAGTCATGGCTATGTAGATCAATGAGTCTT TGGCGATGGGACTGTGCGTAGCATAGACTATGAGGATCAGCCCGAGCTCG ATGGCCTTCACAAAGTGACTGCGTGCATAGAGTCGGTAGTTCTCGGTGAA ACTCTTGTGCTCGACAACAAATCCACGTCCAGTGGCTCTGTACTTTGCTC CACCATGGAGAATGGTTCGACCAAAATAGTGAGCTCTGGTCCCCATTGAG AATGTGTAGAAGACAGAGGAAAGCTGAATCTGCATCCGAATGAAATTCCA TATAGCTAGAAGGAAACCCTCCTCGAGAGACCATTCCACAATCATTGGCA GGGCAGTGAACAGACCAAGCTGAACGATGAACTGCTGGTTCAGTATCACA GCAAGCGCTGCGTTGGTGTCTGTACTGTCTGCTAGAGCGGACTTCTCAAC ACCGCTCAGCGCGAGATAAACCCGGCCCCAGAGGAAAGCGTAAACCGTAA GAATGACCATCATCGTGTTGAAGAAAAACCCGACCGTTGTGTAGAAAAAT GATAACATTCTGAAGAAATCGAGCCTATGACCCAGCCTGTACACATCTCG GCTAAGAACCTGCTCTCCATTCCCACTGGCTACCTTAGCCTCAAACATTG ATATTTGATTCAATCCAACATCCCGGCCCTTCCCAACCTGAATATATGTA CAAAAAACAAGGGTTATGCAATTTACATTGAAGAAACAAGGAACGTTAAG TTGCATGGTTATAACAAAAAAAAAAATTGAACTATAGGATTTCTGTCGCA GTATAAATTAGTTAGAAATATCAAAATAATGAACATTACCAACCTGAATA TACTCGTGGTGGGTGACGTTACCGCCTCGCAATGTGCAATTAAACCCGGC GAAGATGTCTTCACTGATATTTATGACTCTGGAAGCTTTGCTGATACCAC CTCGACTCAAGAACCAGAATCTGTCAAAAACATCGGGGTGACCATAATGC ATTCTGACCTTAAGCGGGTTGGCAAGAACACGCTGACCAAGAGTGACAAA ACTAGTCTCCTGAGCAGACATGAACCACGCCAGAGACGAGACAGAGCCCG TGAAGATGTGCTCCCGGACACCGAGAATAGTTGGCTTTCTGATCCCATGA GATTTTCTAAACTCCTGGAGCAAATTTCTCATCTTGAGAGCCTCCTCAAA ATAATTATCCTGGTTCATATCTATGGTCTGAACAGCATCACCACGGGTAA AGATCATTGCATGATTCTGGTTCTCTGGCTTTCCCTCACCCAGCTTCAAC GGACCAGGCAGCTTCACACGGAATATCTCCACTTCCTTCTCCAACGTGTG ATCGTATTTCACCAGAACTGAGTAATACTCTGTCTCTCCCCTGCCCGCAT GCACCTCATCCACATACGCAATACGGAGGGCTTCATTTTGCTTCATAAGA TACAGAATTTCCTCTGCCTGAGGCTCCTTCTTTGCTTTTTGAGACCCATA GATCTGGCACGCCACGACATATGTGAATTTCATCAATGCAGTCCCATGCT CATGGCCTTTATACAGCATGCTCACGGAGCTAGTTGCTCTGCTTAGAGAA GATCCACCATTTACATCGTCAACCCCATCCAGTCGACCATTTCCCTGCGA ACTCCTCATTGAACCAAGCTCCTGAGCATCCTCCCGAATGTCCATTTCAG ACGCAGAGTCAAGAAAAGCAAGCATCTTAAGAGCCCTGTAATAGTACATC ATTCCTCGAACTGTACGTGCCAAAGTCTGACCTCTGTAGGAAGCCCAAAG CCTGAGCTCTCTCAGCTTGGTTGTCCACAACTCAACATCTGTCTTTATAC CTTCCCTACGCATCCGTTCCTTAAAATTTTTCCATTCGTCAGCATAAATC GTCTGCAGGTAATACAAGGTTGAAATCCCATCCTCAGTCTCGTTTTTGAG CTGTTCTTTGCTGTATACAACTTCCTCGCTGTAGTATGGAGTCAGAACAC TGAACGCCAACATTTTCTCCACCTGAGGTGCATGAGGCAAGTTCATGAAG AGCGAATTGCTGAAGAAGGCAATCCGCCGTCTCGCCTCTAGATTCACAGG GACGCTGTGCATAGAGTCCCTAGAAGTGAGAATTGTGTGTAACCGCCTAA CCTGCCGAAAGAAGTCTTCATTGCTTGCATCGGGAAGCCTAACAGCGTTC TGAAACAGTAACTTGGAGGCTGGATCATGAGGAGTCAACCCCTCATTAGA TAGCTGTTCAGTTGTCTTCTTCTCTATGAAGAACTGTCGTGTTGCAATCT CATAAATCGACTGCAAAACATTCACCACTCGCTCAATATCTGGCTTCTCA GCATTCAGTAGCCCAACCAACTTCTGAAGTGTCTCGTACATCTTTGGCAG AAGGTCCACTTTAAAGGTCTTGGTGAACTGCTCACCCTGAATAGAGACCT CAATCATCTGGAAGAAGATCGTAATGATTTTATGTTCTTCGGTGTCAATC TTGATGATTGAGAGCAGCAGATGTTTGATGCTGTCATATGCCTCAACAAC AGCACAACGCCTGTACTCATTCTTGCATATCTTGTGCCACAGCCATTTAT CAGGAGCATCAACCAGCTCTTTCGCCTGGCTCAGTGCAAGTAAAAGCTCG TTGCACAGCAGGAAACACGGCCAGCGGATAACTGACACATTCCACGAATT CTTTGGCAGCTCCAGTAGCTCTACTTCTCGATCAGAGACTATATCCTCTT CTCTGAAAGCTAAGATTATCTCATTCCAGATCAACGCAAACTTGTTGGCT TCAACCTGATTAGACTCGAGTTTCTTAAACGGCCGCCCAAATCCATACCT CAGCTTCAATCTGCATAAAGTACACAAACTCAAGGTTATTATTATGTTGA AAACTCGAATTCCAAGCTTGTACCGTAAAGACAAACTCTGTATAGTAAAC TATAAATATAGGAATATGCTTGCACAGACTTACCTATGAATGGCGTCCTT AAGCTTGTTACCAAAGCCTCTAGCATTCAGGAGTTGTTCCTCAGGCATTA GGTTGAACTGAATAGCGCTAGCAAAGAACTGAAACCTCAGCCTAAGCTGT CCCATGTCCCTGATCTCCCCCAGATGATCAAACAACCCAACAATAGCACC AACAATCGACGAATAGATTGCGTACCAAATTTGGATATCCATCAGGTATA TCAACACCACTGGCAGCCATAATAACAAGACAGAAAACCTATTGCTCTCG CCAAAGAACTGATGCCACTCATAATCTACCTCCTTTAAGTTCCATAGCAG CTTCGAGGGTTTAATCATTGGTTTAACCTGCAGGAAGTAGCTGAAAATGA ACTTCGTTGCTAGGACAAAGATCCAGAACGCCGAGTACTTGATGTTGTCC ACCAAACCCTCTCTCAAACCTCGACCCACAAAGCTTTTACCCTGGAACCA CCAAGTTAAAGCAAAGAATATTTTCCAATTGCTCTCTTCCAGAAAGTTCC TTATCCACGGGATTATAAACAGAGCCAAAGCCAGGATCTCAGGGACCAAG AATGCCACCACGGCGTAAAGGAATTGGTAGATCTTGTCATTCGCGGCTCT GGACCACTGTCTATCTTGCTTCCTCTGCTTCCAGATGTTCGTGTAGAGAA CAATAAAGGCTATAATCCAAACCGTGGCAGCTACAACCTTCATCAACATT CTGAAAAACAGCCGTTTGGTCTCTCTAGAAATGAGGGGCCGTTGCGAACC AGCGTCCAGCACAGCCTGCAGTAGTCTCATCCCACTCCACGTCAAGAAAA CTGTCAAAAGCCTCACCTGAACATCTCTCGACTTCAAGGCATTCCACATC TGCTTTGCCACCGACCCTCTATCCGGCTTCTCCTCCCAAGCAACTATAAT GGCGGCTTGAAGGAACAAAGCAAGCATCACCCAAAGCCTATCAAAGCTCC TGTAGAGATAAAAAAACGTCCTCCGCTCCACAAAACCGGTCTTCCCAACG CTCTTCCCTCTACTATTCTTGAAGAAACTGCTCCCCAAATCAAGCGGCCA TTTCAACTTACTGAAACACCTATCCGTCCAGAAATACTCATTAATATCAT CATAGTTCCTCCACTTACAATGCGGCTCCGTCCCGTTCTTGCTCTCATTA ATCTCAGCTCGGATCGTCTCGTAAATAGGTTTAACGACGCCGTTTAGGAA AGCGTTCTCCCCAGAGAGAGTAGGCGTATAAGGCTGCCCCGTGTTCTCGT CGAGGCAATCCTCCAACACCTTGTTAAGCTCCGAGGCCATATTGTGGAAG ATGTAACAGACGCACTCGGGCATGAACCTAAGATTCGCGGCCTCGCCCCA CACGAGGAGGTAGAGACCGACGTAGAGAAGCTCCCGCCTCGAATCGGGGC TCCGATCCGAGATCCAGATGTTCGATTTCCTCCCGAGGTAGGAGCACCAG CTGGAGTAGTTCCCGAGGAGCTTGCGGCGGAAGCGGCGGACGACGGCGGG ATCGAGGGAGTCGATGTTGTCGGGGGGAGGGGAGAGGCGCATCTGGGCGT TGGCGAGGTGGAGGACGACGTGCTCGCGCTGGTTGCGGACGTTGTCCTTC TGGAAGCCGAAGAAGAGGGCGAGCCAGTCGAGGAGGTCGTAGTGAGGGCG CCATTGGACGAAGGGAGGACGGCGGAGGTCTCCGACGGTTTTGAGAGCGG CGGCGGCGGCGCGGACCTCGGGGTAGCGGAGGGAAGGGTGGTCGGCGAGG AGGTTGTTGACGGGGATGATGTTGTAGGGCTCCTCCTCGGTTCCCCCCGC CGACGGCCGTCCGGTTTGAGATGGGACGGTGCGGTGGCGGAGGCTCATAG TAGCATGTGGTGGATCTTGGAGATGGTGTGAAGGAGGAGGAGACTGATTC AAAGGATGTGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA GAGATTGAATTGAAGCGTTGCGATATGTTTTTCTCTTTTAGCT