METHOD FOR TREATING HIV/AIDS COMPLICATIONS SUCH AS VIRAL ENCEPHALOPATHY, DRUG-INDUCED ENCEPHALOPATHY, AND NEUROLOGICAL DISORDERS OF IMMUNOCOMPROMISED CONCURRENT OPPORTUNISTIC INFECTIONS INCLUDING MOTOR NERVE, SENSORY NERVE AND OPTIC NERVE DISORDERS

Abstract

The present invention relates to a method for treating HIV/AIDS complications including administering a first Chinese herbal medicine composition to a subject in need; wherein the first Chinese herbal medicine composition is an extract of a first mixture including Polygonatum sibiricum, Astragalus membranaceus, Panax ginseng, Liriope spicata, Schisandra chinensis, Ziziphus zizyphus, Cornus officinalis, Fallopia multiflora, and Salvia miltiorrhiza.

Claims

1. A method for treating HIV/AIDS complications, comprising: administering a first Chinese medicine composition to a subject in need thereof; wherein, the first Chinese medicine composition is an extract of a first mixture comprising Polygonatum sibiricum, Astragalus membranaceus, Panax ginseng, Liriope spicata, Schisandra chinensis, Ziziphus zizyphus, Cornus officinalis, Fallopia multiflora, and Salvia miltiorrhiza.

2. The method of claim 1, wherein the first Chinese medicine composition is prepared by the following steps: providing the first mixture; mixing the first mixture with water to form a second mixture; heating the second mixture to obtain a first crude extract; and filtering the first crude extract to keep a first liquid extract and obtain the first Chinese medicine composition.

3. The method of claim 1, wherein the first mixture comprises 4-6 parts by weight of Polygonatum sibiricum, 2-4 parts by weight of Astragalus membranaceus, 2-4 parts by weight of Panax ginseng, 4-6 parts by weight of Liriope spicata, 1-3 parts by weight of Schisandra chinensis, 2-4 parts by weight of Ziziphus zizyphus, 2-4 parts by weight of Cornus officinalis, 2-4 parts by weight of Fallopia multiflora, and 2-4 parts by weight of Salvia miltiorrhiza.

4. The method of claim 1, wherein the first mixture further comprises Glycyrrhizae radix.

5. The method of claim 4, wherein the first mixture further comprises 2-4 parts by weight of Glycyrrhizae radix.

6. The method of claim 1, further comprising administering a second Chinese medicine composition to the subject in need thereof; wherein, the second Chinese medicine composition is an extract of a third mixture comprising Astragalus membranaceus, Angelica sinensis, Ligusticum striatum, Paeonia veitchii, Salvia miltiorrhiza, Ginkgo biloba, Gastrodia elata, Uncariae ramulus cum uncis, Leonurus japonicas, Aralia cordata, and Achyranthes bidentata.

7. The method of claim 6, wherein the second Chinese medicine composition is prepared by the following steps: providing the third mixture; mixing the third mixture with water to form a fourth mixture; heating the fourth mixture to obtain a second crude extract; and filtering the second crude extract to keep a second liquid extract and obtain the second Chinese medicine composition.

8. The method of claim 6, wherein the third mixture comprises 19-21 parts by weight of Astragalus membranaceus, 3-5 parts by weight of Angelica sinensis, 3-5 parts by weight of Ligusticum striatum, 3-5 parts by weight of Paeonia veitchii, 3-5 parts by weight of Salvia miltiorrhiza, 3-5 parts by weight of Ginkgo biloba, 2-4 parts by weight of Gastrodia elata, 2-4 parts by weight of Uncariae ramulus cum uncis, 2-4 parts by weight of Leonurus japonicas, 2-4 parts by weight of Aralia cordata, and 2-4 parts by weight of Achyranthes bidentata.

9. The method of claim 6, further comprising administering a third Chinese medicine composition to the subject in need thereof; wherein, the third Chinese medicine composition is an extract of a fifth mixture comprising Lycii radicis cortex, Cortex moutan radices, Angelica sinensis, Ligusticum striatum, Paeonia veitchii, Rehmannia glutinosa, Scutellaria baicalensis, Atractylodes lancea, Glycyrrhiza uralensis, Gastrodia elata, Lycium chinense, Dendrobium nobile, Wolfiporia extensa, Cicadae Periostracum, and Senecio scandens.

10. The method of claim 9, wherein the third Chinese medicine composition is prepared by the following steps: providing the fifth mixture; mixing the fifth mixture with water to form a sixth mixture; heating the sixth mixture to obtain a third crude extract; and filtering the third crude extract to keep a third liquid extract and obtain the third Chinese medicine composition.

11. The method of claim 9, wherein the fifth mixture comprises 4-6 parts by weight of Lycii radicis cortex, 4-6 parts by weight of Cortex moutan radices, 2-4 parts by weight of Angelica sinensis, 2-4 parts by weight of Ligusticum striatum, 2-4 parts by weight of Paeonia veitchii, 2-4 parts by weight of Rehmannia glutinosa, 2-4 parts by weight of Scutellaria baicalensis, 3-5 parts by weight of Atractylodes lancea, 2-4 parts by weight of Glycyrrhiza uralensis, 2-4 parts by weight of Gastrodia elata, 2-4 parts by weight of Lycium chinense, 3-5 parts by weight of Dendrobium nobile, 2-4 parts by weight of Wolfiporia extensa, 1-3 parts by weight of Cicadae Periostracum, and 2-4 parts by weight of Senecio scandens.

12. The method of claim 1, further comprising administering a medicine pillow or a medicine mask to the subject in need thereof, wherein the medicine-filled pillow comprises a seventh mixture comprising Pinus tabuliformis, Fallopia multiflora, Cortex albiziae, and Nardostachys chinensis batal; and, the medicine mask comprises a eighth mixture comprising Agastache rugosa, Ephedra sinica, Magnolia liliflora desr, Saposhnikovia divaricate, Mentha Canadensis, Xanthium strumarium, Scutellaria baicalensis, Angelica dahurica, Ligusticum striatum, Boswellia carter, Chrysanthemum morifolium, Senna obtusifolia, and Cymbopogon.

13. The method of claim 12, wherein the medicine pillow is prepared by the following steps: providing and grinding the seventh mixture to form a powder mixture; mixing the powder mixture and a thermal conductive substance to form a ninth mixture; and filling the ninth mixture into a bag to obtain a medicine pillow.

14. The method of claim 12, wherein the seventh mixture comprises 20-40 parts by weight of Pinus tabuliformis, 20-40 parts by weight of Fallopia multiflora, 20-40 parts by weight of Cortex albiziae, and 20-40 parts by weight of Nardostachys chinensis batal.

15. The method of claim 12, wherein the medicine mask is prepared by the following steps: providing the eighth mixture; and filling the eighth mixture into a medicine bag to obtain a medicine mask.

16. The method of claim 12, the eighth mixture comprises 1-2 parts by weight of Agastache rugosa, 1-2 parts by weight of Ephedra sinica, 0.5-1.5 parts by weight of Magnolia liliflora desr, 0.5-1.5 parts by weight of Saposhnikovia divaricate, 0.5-1.5 parts by weight of Mentha Canadensis, 0.5-1.5 parts by weight of Xanthium strumarium, 0.5-1.5 parts by weight of Scutellaria baicalensis, 2-4 parts by weight of Angelica dahurica, 1.5-2.5 parts by weight of Ligusticum striatum, 0.5-1.5 parts by weight of Boswellia carter, 0.5-1.5 parts by weight of Chrysanthemum morifolium, 0.5-1.5 parts by weight of Senna obtusifolia, and 0.5-1.5 parts by weight of Cymbopogon.

17. The method of claim 1, wherein the HIV/AIDS complications comprise pneumonia, meningitis, retinitis, hearing defect, viral encephalopathy, drug-induced encephalopathy, neurological disorders of immunocompromised concurrent opportunistic infections, or immunocompromised disease.

18. The method of claim 1, wherein the Chinese medicine composition is administered via oral administration or injection.

19. The method of claim 6, wherein the second Chinese medicine composition is administered via oral administration or injection.

20. The method of claim 9, wherein the third Chinese medicine composition is administered via oral administration or injection.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0035] The following embodiments are meant to explain the implementation of the present invention, they should be construed as descriptive merely, and should not restrict the remaining part of the present invention. The person having ordinary skills in the art can easily understand other advantages and effects of the present invention. The present invention may also be implemented or applied by other different embodiments, and various details in this specification may also be modified and changed according to different viewpoints and applications without departing from the spirit of the invention.

[0036] Unless specified otherwise, all technical and scientific terms described in the specification and claims of the present invention are defined as follows. In the present invention, the singular term and “the”, may refer to one or more objects, unless specified otherwise. In addition, the term “comprise” is an open-ended transition word which does not limit to the items listed. The foregoing paragraphs are only systematic references and should not be construed as limitations for the subject of the invention. Unless specified otherwise, the materials used in the present invention are commercially available and easy to obtain. Possible sources for obtaining the materials are listed below and it is exemplary only.

Preparation Example 1

[0037] Five parts by weight of Polygonatum sibiricum, 3 parts by weight of Astragalus membranaceus, 3 parts by weight of Panax ginseng, 5 parts by weight of Liriope spicata, 1.5 parts by weight of Schisandra chinensis, 3 parts by weight of Ziziphus zizyphus, 3 parts by weight of Cornus officinalis, 3 parts by weight of Fallopia multiflora, and 3 parts by weight of Salvia miltiorrhiza were provided to form a Mixture-1; the Mixture-1 was mixed with 42 parts by weight of water and decocted for 2.5 hours to form a Crude extract-1 being about 40 parts by weight; the Crude extract-1 was filtered and the filtrate was collected to obtain the Chinese medicine composition-1 of the present preparation example. In the present preparation example, the part by weight was 3.75 grain per part.

Preparation Example 2

[0038] The Mixture-1 of Preparation Example 1 was added with 3 parts by weight of Glycyrrhizae radix to obtain a Mixture-2 of the present preparation example; followed by extraction in a similar manner to Preparation Example 1 in order to obtain a Chinese medicine composition-2 of the present preparation example. In the present preparation example, the part by weight was 3.75 gram per part.

Preparation Example 3

[0039] Twenty parts by weight of Astragalus membranaceus, 4 parts by weight of Angelica sinensis, 4 parts by weight of Ligusticum striatum, 4 parts by weight of Paeonia veitchii, 4 parts by weight of Salvia miltiorrhiza, 4 parts by weight of Ginkgo biloba, 3 parts by weight of Gastrodia elata, 3 parts by weight of Uncariae ramulus cum uncis, 3 parts by weight of Leonurus japonicas, 3 parts by weight of Aralia cordata, and 3 parts by weight of Achyranthes bidentata were provided to form a Mixture-3; and, the Mixture-3 was mixed with 53 parts by weight of water and decocted for 2.5 hours to form a Crude extract-3 being about 40 parts by weight; the Crude extract-3 was filtered and the filtrate was collected to obtain the Chinese medicine composition-3 of the present preparation example. That Leonurus japonicus, Ligusticum striatum, Aralia cordata, and Salvia miltiorrhiza were added to invigorate blood and diuresis; Achyranthes bidentata was added to improve blood circulation in the lower human body; Ginkgo biloba was added to invigorate blood and improve microcirculation; Gastrodia elata and Uncariae ramulus cum uncis were added as ingredients for the treatment of brain diseases. In addition, the part by weight is 3.75 grain per part in the present preparation example.

Preparation Exmaple 4

[0040] Five parts by weight of Lycii radicis cortex, 5 parts by weight of Cortex moutan radices, 3 parts by weight of Angelica sinensis, 3 parts by weight of Ligusticum striatum, 3 parts by weight of Paeonia veitchii, 3 parts by weight of Rehmannia glutinosa, 3 parts by weight of Scutellaria baicalensis, 4 parts by weight of Atractylodes lancea, 3 parts by weight of Glycyrrhiza uralensis, 3 parts by weight of Gastrodia elata, 3 parts by weight of Lycium chinense, 4 parts by weight of Dendrobium nobile, 3 parts by weight of Wolfiporia extensa, 1.5 parts by weight of Cicadae Periostracum, and 3 parts by weight of Senecio scandens were provided to form a Mixture-4; and, the Mixture-4 was mixed with 43 parts by weight of water and decocted for 2.5 hours to form a Crude extract-4 being about 40 parts by weight; the Crude extract-4 was filtered and the filtrate was collected to obtain the Chinese medicine composition-4 of the present preparation example. In the present preparation example, the part by weight was 3.75 grain per part.

Preparation Example 5

[0041] Thirty parts by weight of Pinus tabuliformis, 30 parts by weight of Fallopia multiflora, 30 parts by weight of Cortex albiziae, and 30 parts by weight of Nardostachys chinensis batal were provided to form a Mixture-5; the Mixture-5 was ground to obtain a powder mixture; the powder mixture was mixed with 3000 parts by weight of red beans and then the mixture was filled into a pillow case to obtain a medicine pillow. The way to use this medicine pillow was: microwave heating the medicine pillow for about 3-4 minutes; and applying the medicine pillow to the occipital bone and cervical spine of the subject for hot compress for 30-40 minutes, thereby promoting the vertebral artery and improving the blood supply to the back half of the brain. In addition, the part by weight was 1 gram per part in the present example.

Preparation Example 6

[0042] Fifteen parts by weight of Agastache rugosa, 15 parts by weight of Ephedra sinica, 10 parts by weight of Magnolia liliflora desr, 10 parts by weight of Saposhnikovia divaricate, 10 parts by weight of Mentha Canadensis, 10 parts by weight of Xanthium strumarium, 10 parts by weight of Scutellaria baicalensis,30 parts by weight of Angelica dahurica, 20 parts by weight of Ligusticum striatum, 10 parts by weight of Boswellia carter, 10 parts by weight of Chrysanthemum morifohum, 10 parts by weight of Senna obtusifoha, and 10 parts by weight of Cymbopogon were provided to form a Mixture-6; and, 20 parts by weight of the Mixture-6 was taken and filled into a medicine bag to obtain a medicine mask. The way to use said medicine mask was: microwave heating the medicine mask before use; and, placing the medicine mask on the chest, nose or eyes to promote blood circulation in the carotid or ophthalmic artery, thereby promoting blood supply to the head, face and eyes. In addition, the part by weight was 1 grain per part in the present example.

[0043] Embodiment 1

[0044] The patient of Embodiment 1 was a patient infected with HIV. The patient had dry mouth, body dryness-heat, itchy skin and multiple rashes due to opportunistic infection.

[0045] A treatment of the present invention applied to the patient of Embodiment 1 was described below. From day one, a total amount of the Chinese medicine composition-1 of Preparation Example 1 was administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration. A follow-up report indicated that the patient still took the medicine as of the reporting date; the symptoms of dry mouth and body dryness-heat in the patient were alleviated; and, the skin no longer had itching and rash.

[0046] Embodiment 2

[0047] The patient of Embodiment 1 was a patient infected with HIV, and the patient suffered from chest tightness, palpitation, and pale complexion due to opportunistic infections.

[0048] A treatment of the present invention applied to the patient of Embodiment 2 was described below. From day one, a total amount of the Chinese medicine composition-2 of Preparation Example 2 was administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration. A follow-up report indicated that the patient still took the medicine as of the reporting date; the patient's symptoms of chest tightness and palpitation were significantly relieved, the heart rate was back to normal and the complexion was ruddy.

Embodiment 3

[0049] The patient of Embodiment 3 was a patient infected with HIV, and the patient suffered from multiple pneumonia, respiratory failure, and sepsis due to opportunistic infections.

[0050] A treatment of the present invention applied to the patient of Embodiment 3 was described below. From day one, the total amount of the Chinese medicine composition-1 of Preparation Example 1 and Chinese medicine composition-3 of Preparation Example 3 were administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration. A follow-up report indicated that the patient still took the medicine as of the reporting date; the patient's infection of sepsis was significantly relieved; and, the patient was able to breathe easily without difficulty. In addition, the patient's life had returned to normal.

Embodiment 4

[0051] The patient of Embodiment 4 was a patient infected with HIV, and the patient was unable to stand for long periods due to the weakness of lower limbs caused by opportunistic infections.

[0052] The treatment of the present invention applied to the patient of Embodiment 4 was described below. From day one, the total amount of the Chinese medicine composition-1 of Preparation Example 1 and Chinese medicine composition-3 of Preparation Example 3 were administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration; and, the medicine pillow of Preparation Example 5 was applied to the patient two times a day to promote vertebral artery circulation, thereby improving the blood supply to the back half of the brain. A follow-up report indicated that the patient still took the medicine as of the reporting date; the weakness of lower limbs was significantly relieved; and, the patient was able to walk normally and even walk briskly.

Embodiment 5

[0053] The patient of Embodiment 5 was a patient infected with HIV, and the patient's hands and feet were weak and numb; and, the patient's joints of the fingers were deformed and unable to grasp objects.

[0054] The treatment of the present invention applied to the patient of Embodiment 5 was described below. From day one, the total amount of the Chinese medicine composition-1 of Preparation Example 1, Chinese medicine composition-3 of Preparation Example 3, and Chinese medicine composition-4 of Preparation Example 4 were administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration; and, the medicine pillow of Preparation Example 5 was applied to the patient two times a day. A follow-up report indicated that the patient still took the medicine as of the reporting date; the numbness of the patient's hands and feet disappeared, the patient was able to stand, and the joint deformity was significantly improved.

Embodiment 6

[0055] The patient of Embodiment 6 was a patient infected with HIV, and a blurred vision was in the patient's left eye due to optic nerve damage.

[0056] The treatment of the present invention applied to the patient of Embodiment 6 was described below. From day one, the total amount of the Chinese medicine composition-3 of Preparation Example 3 and Chinese medicine composition-4 of Preparation Example 4 were administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration; and, the medicine mask of Preparation Example 6 was applied to the patient two times a day. A follow-up report indicated that the patient still took the medicine as of the reporting date; and, the patient's symptom of blurred vision has been completely relieved.

Embodiment 7

[0057] The patient of Embodiment 7 was a patient infected with HIV, the patient suffered from hearing loss and binocular retinitis due to meningitis, and almost lost sight in both eyes.

[0058] The treatment of the present invention applied to the patient of Embodiment 7 was described below. From day one, the total amount of the Chinese medicine composition-1 of Preparation Example 1, Chinese medicine composition-3 of Preparation Example 3 and Chinese medicine composition-4 of Preparation Example 4 were administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration; and, the medicine mask of Preparation Example 6 was applied to the patient two times a day. A follow-up report indicated that the patient still took the medicine as of the reporting date; the patient's hearing loss was significantly relieved; and, the patient's eyes were able to see the shape of an object.

Embodiment 8

[0059] The patient of Embodiment 8 was a patient infected with HIV. The patient was unable to walk due to neurological disability, relied on a wheelchair to move and had incontinence of urine and feces. The patient's optic nerves were damaged, and the patient almost blind.

[0060] The treatment of the present invention applied to the patient of Embodiment 8 was described below. From day one, the total amount of the Chinese medicine composition-1 of Preparation Example 1, Chinese medicine composition-3 of Preparation Example 3 and Chinese medicine composition-4 of Preparation Example 4 were administered to the patient every day, wherein the total amount was divided into aliquots for bis in die administration, the medicine pillow of Preparation Example 5 was applied to the patient two times a day; and, the medicine mask of Preparation Example 6 was applied to the patient two times a day. A follow-up report indicated that the patient still took the medicine as of the reporting date; the patient's Modified Rankin Scale (mRS) score was recovered from 5 to 0 after the treatment. In addition, said patient's Barthel Index (Barthel Index) score was improved from 0 to 100 after the treatment. At present, the patient was able to walk normally and do the activities of daily living alone, and the patient's vision was restored.

[0061] Although the present invention has been explained in relation to its preferred embodiment, it is to be understood that many other possible modifications and variations can be made without departing from the spirit and scope of the invention as hereinafter claimed.