BREAKABLE GALENIC CAPSULE

Abstract

The present invention falls within the general field of cosmetics, and in particular, it relates to a breakable capsule (1) with a membrane (2) and core (3) suitable for releasing an active ingredient comprised in the membrane (2), both for cosmetic use and for pharmaceutical use and to the preparation processes thereof. The capsule (1) has good chemical and mechanical stability wherein the capsule, once applied to the skin, reduces or does not generate residues and, at the same time, any residual trace produced by the membrane (2) can be absorbed or adsorbed by the skin. In addition, they have good stability against light and breakage.

Claims

1. A breakable capsule (1) characterised in that: the diameter of the capsule is at least 7 mm, preferably between 7 mm and 30 mm; the flexibility of the capsule is up to 20% the diameter of the capsule; the burst strength of the capsule is from 12 to 25 gr/cm.sup.2 said capsule comprises a core (3) and an outer membrane (2) that surrounds the inner core (3), the outer membrane (2) being characterised in that: the membrane (2) comprises at least 20% water by weight to the total weight of the membrane, preferably the water content by weight in the membrane (2) is between 40% and 99.5% to the total weight of the membrane (2), more preferably between 60% and 99.5%; at least 0.2% of a gelling agent and at least 0.1% of a cosmetically acceptable excipient, to the total weight of the membrane, preferably wherein the gelling agent is between a range of 0.2% and 5% and the cosmetically acceptable excipient is in a range from 0.2% and 10%, both measured with respect to the total weight of the membrane; calcium, magnesium or salts thereof optionally an active ingredient in a concentration of at least 0.01% to 10% to the total weight of the membrane (2); optionally a preservative, which concentration in the solution is between 0.01 and 5%; And wherein the thickness of the membrane (2) is at least 150 μm wherein the thickness of the membrane (2) is at least 300 μm.

2. (canceled)

3. The breakable capsule (1) according to claim 1, wherein the calcium salt is selected from the group consisting of calcium ascorbate, calcium aspartate, calcium carbonate, calcium benzoate, calcium chloride, calcium citrate, calcium gluconate, calcium glycerophosphate, calcium glycinate, calcium ketoglutarate, calcium lactate, calcium phosphate, calcium carbonate, calcium sulfate and calcium glycinate, calcium tartrate, calcium pantothenate, derivative of Carrageenan from algae, calcium polyglutamate crosspolymer, calcium glycerophosphate and a mixture thereof, and/or the magnesium salt are selected from the group consisting of magnesium hydroxide, magnesium carbonate hydroxide, magnesium calcium silicate, dolomite, magnesium chloride, magnesium citrate, magnesium alginate, magnesium glycerophosphate, magnesium glycinate, magnesium lactate, magnesium myristate, magnesium PCA or mixtures thereof.

4. The breakable capsule (1) according to claim 1, wherein the amount of calcium and magnesium is in a concentration of at least 0.01% to 3% to the total weight of the membrane.

5. (canceled)

6. (canceled)

7. The breakable capsule (1) according to claim 1, wherein the cosmetic composition comprises an active ingredient that is a cosmetically acceptable oil, selected from a group consisting of Prunus amygdalus dulcis, Argania spinosa, Simmondsia chinensis seed oil, Camellia oleifera seed oil, aloe oil, Citrus nobilis peel oil and mixtures thereof.

8. (canceled)

9. (canceled)

10. (canceled)

11. The breakable capsule (1) according to claim 1, wherein the percentage by weight of the membrane (2) to the weight of the capsule (1) is between 5-30% and/or the percentage by weight of the core (3) to the weight of the capsule (1) is in a range between 70-95%.

12. The breakable capsule (1) according to claim 1, wherein the active ingredient is in the core (3), or wherein the active ingredient is in the core (3) and in the membrane (1).

13. (canceled)

14. (canceled)

15. The breakable capsule (1) according to claim 1, wherein the gelling agent of the membrane (2) is selected from the group consisting of sodium alginate, carrageenan, gellan gum, acacia gum, guar gum, Ceratonia siliqua gum, sclerotium gum, hydrolysed Caesalpinia spinosa gum, xanthan gum, cellulose gum, cellulose and cellulose derivatives, Lessonia nigrescen powder, Agar, Chondrus crispus, Kelco-Care diutan gum, dihydroxy xanthan gum, biosaccharide gum, Boswellia serrata gum Colophonium, dextran, dextrin, gelatin, Ghatti gum, Himanthalia elongata powder, maltodextrins, mannitol, mel powder, xanthan gum, Pullulan, trehalose, monosaccharides, disaccharides, polysaccharides, polyvinylpyrrolidone, carbomer; acrylates, pectins, gelatins, Astragalus gum, Cassia gum; rice, tapioca, wheat and corn starch, Rosin, Sterculian Urens gum, silica, Ulva lactuca powder and mixtures thereof, preferably the gelling agent of the membrane (2) is selected from the group consisting of alginine, sodium alginate, carrageenan, xanthan gum, maltodextrin and gellan gum.

16. (canceled)

17. The breakable capsule (1) according to claim 1, wherein the active ingredient is selected from the group consisting of hyaluronic acid and salts thereof; mucopolysaccharides; Aloe vera, Aloe barbadensis leaf powder or juice and aloe plant juices; aqueous plant extracts, oily plant extracts; amino acids, peptides and proteins; vitamins, minerals and a mixture thereof.

18. The breakable capsule (1) according to claim 1, wherein the core or the cosmetically acceptable excipient is a cosmetically acceptable carrier suitable for forming saline, aqueous, alcoholic and oily solutions; oily external phase, aqueous external phase and silicone external phase emulsions; aqueous and oily gels; and powders.

19. (canceled)

20. (canceled)

21. The breakable capsule (1) according to claim 1, wherein the excipient is at least one plasticiser that is selected from the group consisting of propanediol, glycerol, propylene glycol of a molecular weight (Mn) between 400 and 2000, polyethylene glycol of a molecular weight (Mn) between 400 and 4000, pentylene glycol and triacetin.

22. The breakable capsule (1) according to claim 1, wherein the excipient is at least one preservative that is selected from the group consisting of benzyl alcohol, dehydroacetic acid, glycerin soja oil, tocopherol, glycols, benzoate and phosphate salts, ethylhexylglycerin, phenoxyethanol.

23. The breakable capsule (1) according to claim 1, wherein the outer membrane (2) and/or the inner core (3) comprise: at least one dye; and/or at least one aromatic agent.

24. (canceled)

25. The breakable capsule (1) according to claim 1, wherein the membrane (2) disintegrates by rubbing on the skin while the components thereof are absorbed or adsorbed by the skin by at least 85%, both processes occurring in a total time between 25 and 150 seconds, preferably between 25 and 120 seconds.

26. (canceled)

27. The breakable capsule (1) according to claim 1, which is stable for at least 30 weeks at room temperature between 15-25° C., preferably 14 weeks, or which is stable for at least 12 weeks at a temperature of 40° C., preferably 8 weeks.

28. A method for preparing a breakable capsule (1) according to claim 1, comprising the following steps: a) Providing a mixture comprising at least one gelling agent, one excipient and cosmetically acceptable water; b) Providing a second mixture comprising an aqueous phase, at least one calcium and/or magnesium salt, optionally an oil and an emulsifier; c) Adding the mixture obtained in step b) to the mixture obtained in step a) in such a way that when adding the mixture of step b) to step a), the mixture of step b) precipitates on the mixture of step a) forming a solid or semi-solid sphere; d) Adding the sphere obtained in step c) to a water and/or oil bath.

29. The method for preparing a breakable capsule (1) according to claim 1, comprising the following steps: a) Providing a mixture comprising at least one gelling agent, one excipient and cosmetically acceptable water; b) Providing a second mixture comprising at least one pharmaceutically and/or cosmetically acceptable excipient and/or an active ingredient, preferably the active ingredient is an essential oil or a fatty acid; c) Simultaneously mixing the mixture of step a) and b) by using a double-walled concentric injector to provide a spherical cosmetic composition comprising the components of steps a) and b); d) Adding the spherical cosmetic composition obtained in step c) to a solution comprising a calcium or magnesium salt until a solid sphere is formed, preferably wherein the concentration of the calcium and magnesium salt in the solution is between 0.01% and 5% by weight; e) Adding the solid sphere obtained in step d) to a bath comprising water and/or oil to obtain the spherical breakable capsule.

30. The method for preparing a capsule (1) according claim 29, wherein the double-walled concentric injector comprises dosing hoppers in order to dose the addition of the mixtures obtained in step a) and b) in step c).

31. (canceled)

32. (canceled)

Description

DESCRIPTION OF THE FIGURES

[0067] FIG. 1 shows the structure of the capsule (1) of the present invention, in which the membrane (2) and the inner core (3) can be seen.

EXAMPLES

Example 1: Composition and Method for Preparing the Breakable Capsule (1) of the First Aspect by Means of the Method of the Second Aspect

[0068] The components of the membrane (2) of the capsule 1 are shown in Table 1. The inner core (3) was made up of a cosmetic base that corresponded to the composition described in Table 2.

TABLE-US-00001 TABLE M1 Table M1: components of the membrane (2) of the capsule 1 Excipients/ Weight Functionality Active ingredients % g Solvent Demineralised water 97.654 483.27 Gelling agent Sodium alginate 0.508 2.500 Gelling agent Carrageenan 0.203 1.000 Active ingredient Sodium hyaluronate 0.010 0.050 Plasticiser Propanediol 0.346 1.700 Calcium salt Calcium lactate 0.1 0.5 Calcium salt Calcium 0.01 0.05 glycerophosphate Preservative Benzyl alcohol 1.169 5.750 Dehydroacetic acid

TABLE-US-00002 TABLE N1 Table N1: components of the core (3). Excipients/ Weight Functionality Active ingredients % g Solvent Demineralised water 97.25 466.00 Gelling agent Xanthan Gum 0.63 3.00 Calcium salt Calcium lactate 0.4 2 Calcium salt Calcium glycerophosphate 0.04 0.2 Plasticiser Propanediol 0.21 1.00 (propylene glycol) Active Sodium hyaluronate 0.01 0.05 ingredient Active Aloe Barbadensis 0.01 0.05 ingredient leaf juice powder Various dyes White, green, purple 0.26 1.24 Preservative Benzyl alcohol 1.20 5.75 Dehydroacetic acid

[0069] The method for preparing the capsule (1) according to the second aspect

[0070] The components of Table 1a were mixed at a temperature between 30° and 40° until forming a mixture referred to as mixture A.

TABLE-US-00003 TABLE 1a Table 1a: Components of mixture A of step a) Excipients/ Weight Functionality Active ingredients % g Solvent Demineralised water 98.283 483.55 Gelling agent Sodium alginate 0.508 2.500 Gelling agent Carrageenan 0.203 1.000 Active Sodium hyaluronate 0.010 0.050 ingredient Plasticiser Propanediol 0.346 1.700 Preservative Benzyl alcohol 1.169 5.750 Geogard ® 221 Dehydroacetic acid

TABLE-US-00004 TABLE 1b Table 1b: Components of mixture B of step b) Excipients/ Weight Active ingredients % g Solvent Demineralised water 97.12 466.00 Gelling agent Xanthan Gum 0.63 3.00 Calcium salt Calcium lactate 0.52 2.50 Calcium salt Calcium 0.05 0.25 glycerophosphate Plasticiser Propanediol 0.21 1.00 Active Sodium hyaluronate 0.01 0.05 ingredient Active Aloe Barbadensis 0.01 0.05 ingredient leaf juice powder Various dyes White, green, purple 0.26 1.24 Preservative Benzyl alcohol 1.20 5.75 Geogard ® 221 Dehydroacetic acid

[0071] Mixture B is prepared according to Table 1 b and is also referred to as serum. Once mixture B was prepared and at a temperature between 20°−25° C., said mixture was added dropwise to the mixture A.

[0072] The mixture obtained in the previous step is left to rest for 15 to 45 seconds until a capsule is formed. After this time, the capsule (1) was removed and added to a container with distilled water at a temperature of 20-25°, wherein it was left to act for 1-10 minutes in order for the reaction to stop and any unwanted components to be eliminated from the capsule (1). Once the capsule is obtained, it is stored in a container containing a suitable medium and the process is repeated until the desired number of capsules is achieved. Once the process was finished, the container was stored in a dark, refrigerated place, such as a refrigerator.

[0073] It was confirmed that the capsules of Example 1 are stable at a temperature of 40° C. for at least 3 months.

[0074] The capsules of Example 1 had the following characteristics: [0075] B strength: 25 gf/cm.sup.2. [0076] Capsule diameter: 10 mm [0077] Flexibility: the diameter of the capsule can expand up to 0.42 cm (limit up to breakage of the membrane (2)), therefore, up to more than 400% of its diameter [0078] Total weight: 0.47 g [0079] Weight of the core (3): 0.37 g (79%) [0080] Weight of the membrane (2): 0.10 g (21%) [0081] Thickness of the membrane (2): 550 microns [0082] Internal volume: 0.52 ml (including membrane (2))/0.38 ml (without membrane (2))

Example 2: Capsule 2 and Method for Preparing the Capsule (1)2 by Means of the Process of the Second Aspect of the Invention

[0083] The components of the membrane (2) of the capsule (1)2 are shown in Table M2.

[0084] The inner core (3) was made up of the components and quantities of Table N1.

TABLE-US-00005 TABLE M2 Table M2: components of the membrane (2) of the capsule (1)2 Excipients/ Actual weight Functionality Active ingredients % g Solvent Demineralised water 96.3 473.8 Gelling agent Sodium alginate 0.62 3.00 Calcium salt Calcium lactate 0.41 2 Calcium salt Calcium 0.04 0.2 glycerophosphate Gelling agent Maltodextrin 1.22 6.00 Active ingredient Sodium hyaluronate 0.01 0.05 Flexibility Propanediol 0.26 1.25 Preservative Benzyl alcohol 1.18 5.75 Geogard ® 221 Dehydroacetic acid

TABLE-US-00006 TABLE N1 Table N1: components of the core (3) of capsule (1)2. Excipients/ Weight Functionality Active ingredients % g Solvent Demineralised water 97.25 466.00 Gelling agent Xanthan Gum 0.63 3.00 Calcium salt Calcium lactate 0.4 2 Calcium salt Calcium 0.04 0.2 glycerophosphate Plasticiser Propanediol 0.21 1.00 Active Sodium hyaluronate 0.01 0.05 ingredient Active Aloe Barbadensis 0.01 0.05 ingredient leaf juice powder Various dyes White, green, purple 0.26 1.24 Preservative Benzyl alcohol 1.20 5.75 Geogard ® 221 Dehydroacetic acid

[0085] To prepare the capsule 1(2), the same method of preparation as in Example 1 was followed. To do so, the components of mixture A were used, as described in Table 2a.

TABLE-US-00007 TABLE 2a Table 2a: Components of mixture A of step a) Excipients/ Actual weight Functionality Active ingredients % g Solvent Demineralised water 96.7 476 Gelling agent Sodium alginate 0.62 3.00 Gelling agent Maltodextrin 1.22 6.00 Active ingredient Sodium hyaluronate 0.01 0.05 Flexibility Propanediol 0.26 1.25 Preservative Benzyl alcohol 1.18 5.75 Geogard ® 221 Dehydroacetic acid

[0086] Components of mixture B that are used are the same as those described in Table 1b (Example 1)

[0087] The capsules (1)2 had the following characteristics: [0088] Burst strength: 35 gf/cm.sup.2. [0089] Diameter: 10 mm [0090] Flexibility: the diameter of the capsule (1) can expand up to 0.48 cm (limit up to breakage of the membrane (2)). Therefore, up to 480% of its diameter [0091] Total weight: 0.49 g [0092] Weight of the core (3): 0.37 g (77%) [0093] Weight of the membrane (2): 0.12 g (23%) [0094] Thickness of the membrane (2): 600 microns [0095] Internal volume: 0.52 ml (including membrane (2))/0.37 ml (without membrane (2))

Example 3: Method for Preparing the Capsule (1)3 by Means of the Technique of the Method of the Third Aspect of the Invention

[0096] This process required the use of a double-walled concentric injector with the corresponding hoppers thereof to correctly dose the drip.

[0097] 1—Membrane (2)

[0098] The components of the membrane (2) of the capsule 3 are shown in Table M3.

TABLE-US-00008 TABLE M3 Table M3: components of the membrane (2) of the capsule (1)3. Excipients/ Weight Functionality Active ingredients % g Solvent Demineralised water 97.75 481.00 Gelling agent Sodium alginate 0.56 2.75 Gelling agent Gellan gum LA 0.06 0.28 Active Aloe Barbadensis 0.01 0.05 ingredient leaf juice powder Plasticiser Propanediol 0.30 1.50 Calcium salt Calcium lactate 0.182 0.9 Calcium salt Calcium 0.02 0.1 glycerophosphate Preservative Benzyl alcohol 1.17 5.75 Geogard ® 221 Dehydroacetic acid

[0099] 2—Core (3)

[0100] The core of Example 3 is a complex cosmetic oil. The components of said oil are described in Table N3.

TABLE-US-00009 TABLE N3 Table N3: components of the core (3) N3. Excipients/ Weight Functionality Active ingredients % g Oil Prunus Amygdalus Dulcis Oil 83 415 (sweet almond oil) Oil Argania Spinosa Oil 4 20 (argan oil) Oil Simmondsia Chinensis seed oil 10 50 (Jojoba seed oil) Oil Camellia Oleifera Seed Oil 1 5 Oil Citrus Nobilis Peel 1.5 7.5 (mandarin peel oil) Antioxidant Glycine Soja Oil, Tocopherol, 0.5 2.5 Beta-sitosterol, squalene

[0101] Process for Preparing the Capsule (1)3, According to the Third Aspect of the Invention.

[0102] The compounds forming part of the membrane (2), Table M3, with the exception of the calcium salts, were homogeneously mixed at a temperature between 30° C. and 40° C. These compounds are listed below in Table Mixture 3a.

TABLE-US-00010 TABLE Mixture 3a Table Mixture 3a: mixture of the components that are added to the mixture 3a of step a) Excipients/ Weight Functionality Active ingredients in g Solvent Demineralised water 482.00 Gelling agent Sodium alginate 2.75 Gelling agent Gellan Gum LA 0.28 Active ingredient Aloe Barbadensis 0.05 leaf juice powder Plasticiser Propanediol 1.50 Preservative Benzyl alcohol 5.75 Dehydroacetic acid

[0103] The components of the mixture 3a were mixed in a temperature range between 20°−25° C. until a homogeneous mixture was obtained. Subsequently, they were placed in the hopper of the outer chamber of a double-walled concentric injector. Then the mixture of the components of Table N3 was prepared at a temperature between 20°−25° C. until a homogeneous mixture was obtained. Once said oil was obtained, it was placed in the hopper connected to the inner chamber of the double-walled concentric injector.

[0104] The components of the tables, Mixture 3a and N3, are simultaneously added from the injector, from a determined height of between 0.1 cm and 2 cm, in the bath A. Bath A comprises an aqueous solution of a calcium salt, as described in Table 4. The components of the reagent bath (bath A) are shown in Table 4.

TABLE-US-00011 TABLE 4 Table 4: components of bath A Excipients/ Weight Functionality Active ingredients % g Solvent Demineralised water 99.5 995 Calcium salt Calcium lactate, 0.5 5 Calcium glycerophosphate. Ratio 10:1

[0105] The contents of the previous step were left in the bath for 10 to 20 seconds until a capsule (1) was formed. After this time, the capsule (1) was removed from bath A and added to a container with distilled water at a temperature of 20-25° (bath B), wherein it was left to act for 1-10 minutes in order for the reaction to stop and the capsule (1) to be obtained clean of other unwanted components. Once the capsule is obtained, it is stored in a container containing a suitable medium and the process is repeated until the desired number of capsules is achieved.

[0106] Once the process was finished, the appropriate controls were carried out. The capsules were then stored in a suitable container which contains a suitable stability medium, as mentioned above, under temperature and humidity conditions that keep them stable until the time of individual packaging.

[0107] The capsules 3 had the following characteristics: [0108] Burst strength: 32 gf/cm.sup.2. [0109] Diameter: 10 mm [0110] Flexibility: the diameter of the capsule can expand up to 6 mm (limit up to breakage of the membrane (2)). Up to 60% of its diameter. [0111] Total weight: 0.38 g [0112] Weight of the core (3): 0.29 g (75%) [0113] Weight of the membrane (2): 0.10 g (25%) [0114] Thickness of the membrane (2): 500 microns [0115] Internal volume: 0.52 ml (including membrane (2))/0.39 ml (without membrane (2))

Example 4: Breakable Capsule (1) Composition of the First Aspect Prepared According to the Method of Preparation of the Second Aspect (Reverse Esterification)

[0116]

TABLE-US-00012 MEMBRANE COMPOSITION % by % by weight weight Excipients/ in the in the Functionality Active ingredients capsule membrane Solvent Aqua 16.437 97.24 Gelling agent Algin 0.077 0.45 Gelling agent Maltodextrin (bio) 0.102 0.60 Flexibility Propanediol 0.051 0.30 Calcium salt Calcium Lactate 0.056 0.33 Calcium salt Calcium Glycerophosphate 0.037 0.21 Active Hyaluronic Acid 0.002 0.01 ingredient Preservative Benzyl Alcohol, 0.153 0.90 Dehydroacetic Acid Gelling agent Xanthan Gum 0.085 0.50 TOTAL 17.000 100

TABLE-US-00013 CORE COMPOSITION % by % by weight weight Excipients/ in the in the Functionality Active ingredients capsule core Active INCI Natural Mint Hand Gel 82.544 99.45 ingredient Solution* Calcium salt Calcium Lactate 0.274 0.33 Calcium salt Calcium Glycerophosphate 0.183 0.22 TOTAL 83.000 100

[0117] The INCI Natural Mint Hand Gel Solution* comprises: Water, propanediol, Aloe barbadensis leaf juice, Leuconostoc/Radish Root Ferment Filtrate. Benzyl alcohol, C13-15 alkane, decyl glucoside, succinoglycan, Peppermint oil, citric acid, dehydroacetic acid, indigo dye leaf extract, mica, tin oxide, titanium oxide. [0118] Capsule weight: 0.28 g. Membrane Weight 0.0477 g and Core Weight 0.233 g. [0119] Brust strength: 25 gf/cm.sup.2

[0120] The burst strength can be measured by a texture analyser.

[0121] To carry out the burst strength test, a 2 mm cylinder probe was used to determine burst strength and/or compression point of the membrane at the point of contact. The capsule is deposited perpendicular to the downward direction of the cylindrical probe which penetrates and breaks the sample at a constant speed. The texture analyser measures the force required to break the capsule.

[0122] Stability Controls of the Capsules 1, 2 and 3.

[0123] Once the capsules were prepared, the stability thereof was determined; to do so, different strength assays and aging tests were performed in the laboratory.

[0124] Stability tests at different temperatures: These tests measured the stability of the capsules of Examples 1, 2 and 3 as a cosmetic. Duration of the stability test was between 12 and 14 weeks.

[0125] Room temperature: Between +18° and +25° C.

[0126] Aim: To evaluate the stability of the capsules at room temperature

[0127] Results at room temperature: The capsules showed no change in any of the cases

[0128] Aim: To age the product in an accelerated manner, at 40° C. in the oven, in order to ensure the stability thereof at temperature over real time. The temperature was maintained constant during the 12 or 14 weeks at 40° C.

[0129] Results: The capsules do not undergo any type of change. Bleeding of the colours towards the external liquid also does not appear, meaning that they remain stable throughout the entire process of the study.

[0130] Aim: To test the stability of the product at low temperatures, +4° C. and +8° C.

[0131] Results: The capsules do not undergo any type of change

[0132] Light stability tests:

[0133] Aim: Light tests are essential for all products whose final packaging is transparent or translucent. It was observed whether there were changes in the behaviour of the product in terms of the stability or physical appearance thereof against 2 types of light.

[0134] a) Natural (without direct solar radiation) and

[0135] b) Artificial “fluorescent”, the type of light usually found in commercial buildings.

[0136] Results: The capsules do not undergo any type of change. The capsules behave in a stable manner against the two types of lights tested.

[0137] In conclusion, the capsules of the first aspect of the invention and those obtained from the second and third aspects were stable to breakage, texture and the application test thereof, especially after 30 weeks at room temperature between 18-25° C., preferably 14 weeks, and/or after 12 weeks at 40° C., preferably 8 weeks, and no type of alteration was observed

[0138] Structural and Mechanical Stability TEST of the Membrane

[0139] If the membrane remains stable over time and under forced temperature conditions, it must be able to disintegrate when pressure is applied with the fingers and be able to mix with the core.

[0140] The following is also analysed: [0141] A—Dissolution and mixing time of the membrane and the core once pressure is exerted and until a homogeneous mixture is obtained in which the products form a single phase. [0142] Method: [0143] 1.—A sample is placed in the palm of the hand. [0144] 2.—When a digital stopwatch is started, the capsule (1) is broken with the other hand and the contents rubbed until the film of the membrane disintegrates until forming a homogeneous mixture in a single phase together with the core. [0145] 3.—The digital stopwatch is observed and the time is measured. (Time A) Time A is between 5 and 25 seconds, preferably less than 15 seconds. [0146] B—Acting time on the skin after application thereof; the action can be absorption or adsorption depending on the excipients or active ingredients of the new phase, by at least 85% and preferably 100%. [0147] The mixture obtained at the end of part A is applied to the desired area of the skin as an ordinary cosmetic and it is necessary to wait until the skin shows the cosmetic's intended effect. Mainly, it is observed that there are no product traces on the skin and the product is not sticky. [0148] The digital stopwatch is observed and the time is measured. (Time B). Time B is between 20 and 120 seconds, preferably between 20 and 60 seconds, more preferably between 20-40 seconds. [0149] The sum of the times will give us the total time, which will be the sum of the dissolution and mixing time of the membrane and the core once pressure is exerted and until a homogeneous mixture is obtained in which the products form a single phase, time A, and the time in which the product is absorbed or adsorbed by the senses (vision and touch) on the skin, time B. The total time (time A+B) is between 25 and 150 seconds, preferably between 25 and 85 seconds, more preferably between 25 and 45 seconds.