Plant extract for hair tonic for treating baldness and preventing hair loss and hair bulb regenerator

Abstract

The present invention relates to an extract from Pteridium Arachnoideum or Pteridium Aquilinum and the preparation process thereof, useful for re-growing hair in subjects who have experienced hair loss due to any cause on head and eyebrow.

Claims

1. A composition base selected from the group consisting of creams, ointment, and emulsions, said composition base comprising an alcoholic extract from leaves, stems, roots or rhizomes of Pteridium arachnoideum, wherein the composition base containing from 1% to 99% of the extract by weight or volume.

2. The COMPOSITION BASE according to claim 1, in combination with a cosmetic.

3. The COMPOSITION BASE according to claim 1, in combination with a pharmaceutical product.

4. The COMPOSITION BASE according to claim 1, wherein the extract has a 92% alcohol content.

5. The COMPOSITION BASE according to claim 1, in combination with phytocosmetics.

6. The COMPOSITION BASE according to claim 1, in combination with soaps, shampoos, conditioners, hair gel, aerosol hair sprays, moisturizers, cream rinse, mousses, or oils.

7. The COMPOSITION BASE according to claim 1, in combination with topical pharmaceuticals.

8. The COMPOSITION BASE according to claim 1, in combination with aerosols, water in oil, or oil in water emulsions.

9. The COMPOSITION BASE according to claim 1, in combination with formulations containing hydroethanolic, ethanolic or oily extracts derived from natural sources or synthetic presentations containing any percentage of weight.

10. The COMPOSITION BASE according to claim 1, in combination with cosmetics, phytocosmetics, or topical pharmaceuticals containing from 1% to 99% of the extract by weight or volume.

11. The COMPOSITION BASE according to claim 1, in combination with cosmetics, phytocosmetics, or topical pharmaceutical products having formulations containing any percentage by weight.

12. The COMPOSITION BASE according to claim 1, in combination with cosmetics, phytocosmetics, or topical pharmaceutical products comprising formulations with tannins.

13. The COMPOSITION BASE according to claim 1, in combination with cosmetics, phytocosmetics, or topical pharmaceutical products having formulations associated with a drug, a vitamin, a salt, a sugar or any excipient in any percentage.

Description

BRIEF DESCRIPTION OF THE GRAPHICS

(1) FIG. 1—Monitoring the extraction in ethanol by UV-Vis spectroscopy.

(2) FIG. 2—Monitoring the extraction in isopropanol by UV-Vis spectroscopy.

(3) FIG. 3—Comparison of absorption versus time of extraction in ethanol and isopropanol.

(4) FIG. 4—Comparison of the spectra of absorption of the extracts in water, ethanol, and isopropanol after 26 hours of extraction.

(5) FIG. 5—Emission spectrum of the ethanol extract, λexc=365 nm.

(6) FIG. 6—Excitation spectrum of the ethanol extract, λemi=672 nm.

(7) FIG. 7—Back of the subject's scalp (subject “A”), on the third day of treatment. It is observed the growth of new hair in sparse locations, new hair strand is strong and in natural color, brown (1 cm2 area on top of the skull: no hair strands).

(8) FIG. 8—Subject “A” within one week of treatment, showing the hair growth, increasing in caliber and, at the same time, noticing the appearance of new hair strands and formation of visible hair bulbs.

(9) FIG. 9—Subject “A” in one month of treatment, the hair strands begin to emerge throughout the treated, but still, rarefied area.

(10) FIG. 10—Subject “A” in three months of treatment (after skipping a month without applying the product, for the reason of the study), many hair strands have grown, packing more densely on the scalp, showing the presence of hair follicles in greater amount, to cover the bald area.

(11) FIG. 11—Subject “A” within five months of treatment. One can notice the increasing growth and development of hair strands, in addition to its strengthening and concentration, virtually covering the entire bald area studied.

DETAILED DESCRIPTION OF THE INVENTION

(12) The invention consists of the use of extract of Pteridium Arachnoideum or Pteridium Aquilinum as capillary tonic. The genus Pteridium contains a wide variety of chemical compounds, including tannins; shikimic, succinic and fumaric acids; pterosins; “pterosideos”; quercetin; prunasin; carotenoids; chlorophil and catecholamines. In particular, quercetin is a natural flavonoid having pharmacological properties such as anti-inflammatory, anticarcinogenic (because it acts on the immune system), antiviral, anti-histamine, anti-allergic, cardiovascular, it influences on the inhibition of cataracts in diabetics, among other benefits. High concentrations of quercetin are found in apples, onions, tea, broccoli and red wine. As for the catecholamines, they are chemical compounds derived from the amino acid tyrosine. Some of them are biogenic amines. The catecholamines are soluble in water and circulate in the blood 50% bound to plasma proteins. The most abundant catecholamines are adrenaline, noradrenalin and dopamine. As hormones, they are released by the adrenal gland during stress, such as psychological stress, or hypoglycemia. Regarding fumaric acid, recent studies have shown the efficacy of its derivatives in psoriasis.

(13) The extract of Pteridium Arachnoideum or Pteridium Aquilinum was prepared as tonic and facilitator of hair growth. Its action occurs in the first days of dermal application. Experiments were conducted to better characterize its qualities. The tonic has promoted total stoppage of hair loss in men and women in one week, and hair growth has started from the third day of application. In all case studies, it was observed that its action is cumulative, preventing the fall of hair and stimulating the growth of new hair strand with daily treatment. The extract of Pteridium Arachnoideum or Pteridium Aquilinum encourages the maximum growth of the hair strands, increases hair strength, leads to the growth of hair strand where there is live bulb, and reverses the process of baldness in a short time. Experience shows that in people who had been bald for up to fifteen years, plenty of new hair growth occurred in a short period of time. In people who had been bald for more than fifteen years the process is slower, however, the action of this extract is observed in the activation of the hair bulbs, and the growth of thin hair follicles in a period of three months of treatment.

(14) The action of this tonic also seems to indicate that it fights leucotricose, which is responsible for the loss of natural hair color by the lack of melanin production by the melanocyte cell.

(15) Also reported were cases of disappearance of seborrhea with the use of the alcoholic extract of Pteridium Arachnoideum or Pteridium Aquilinum.

(16) The objective of this invention is:

(17) A—Using the extract of Pteridium Arachnoideum or Pteridium Aquilinum as hair tonic.

(18) The advantages of this invention using the extract of Pteridium Arachnoideum or Pteridium Aquilinum are that it is the most potent and effective than any other product on the market; its action occurs rapidly and it is lasting, in all phases of hair growth, development and maintenance of hair cells and hair bulbs; it is natural, safe, painless, and easy to apply.

(19) The present invention consists of:

(20) a) Obtaining the hair tonic by extracting the active principle in a simple and quick way, without the need for many steps of synthesis and purification of synthetic dyes;

(21) b) Utilizing Pteridium Arachnoideum or Pteridium Aquilinum as a natural species that naturally contains the active ingredient for the hair tonic.

Experimental Procedures

(22) A—Preparation of Tonic by Extraction

(23) In the beginning of the experimental procedures the leaves of Pteridium Arachnoideum or Pteridium Aquilinum were harvested, crushed and left to decoction in water, ethanol or isopropanol and then filtered.

(24) FIGS. 1 and 2 show the evolution of the extraction of active principles in ethanol and isopropanol respectively, accompanied by an increase in visible light absorption of the extract with the extraction time. The electronic spectra show intense bands in the visible, typical of the chlorophyll absorption (maximum absorption at 667, 610, 538 and 413 nm), carotenoids (maximum absorption at 465 and 432 nm) [4] region. Bands in the ultraviolet region can be attributed to the electronic transitions of prunasin, present in fern. Although the prunasin plant has cyanogenic effect, mostly from fresh leaves and stem [5,6], there was no HCN gas evolution during the extraction, perhaps because of the use of dry leaves.

(25) FIG. 3 is a comparison of the absorption of active ingredients regarding time and the two different solvents, being mostly evident the efficiency of the extraction in ethanol. Furthermore, we note that after 26 hours it already reaches constancy in the values of absorption, indicating that it is not necessary to go beyond this timeframe for the efficacy of the extraction.

(26) FIG. 4 compares the absorption spectra of the extracts obtained with three different solvents, being, water, ethanol and isopropanol, after 26 hours of extraction, indicating that water is not able to extract carotenes or chlorophyll present in the plant, resulting in an electronic spectrum band without characteristics in the visible region.

(27) In FIG. 5, the ethanol extract exhibits emission maximum at 672 nm, assigned to the emission of chlorophyll, and the corresponding excitation spectrum, in FIG. 6, is similar to the absorption spectrum of this species.

(28) The pH of the extracts (water, 5.8; ethanol, 5.0; isopropanol, 5.7) is slightly acidic and viable for cutaneous use.

(29) TLC chromatography of the ethanol extract solution using a 1:1 acetone:isopropanol showed three different spots: one of green color, related to chlorophyll, with an Rf=0.56 and two other colors developed using irradiation at 250 nm Rf equal to 0.67 and 0.90.

(30) Mesoporous TiO2 films were immersed in ethanol extract for 1 day. The TiO2 acquired a pale greenish tinge, even with the solution acidified to pH 3, it was not possible to obtain the absorption spectrum in the visible. By removing these films from the solution, the adsorbed dye rapidly oxidizes, turning to beige color.

(31) B—Application of the Tonic on the Scalp

(32) The analysis of the action of the product makes us believe that most likely it acts in decreased androgen DHT, preventing the conversion of testosterone to DHT in the hair follicles of the scalp, in addition to other forms of action yet to be studied. However, it was observed a stoppage of hair loss in female subjects undergoing strong chemotherapy treatments, as well as growth and maintenance of hair, thus evidencing additional forms of action.

(33) The extract effectively acts to induce hair growth, hair, and skin cells (capillary bulb) regeneration.

(34) The extract has been proven effective for inducing the creation of hair cells, causing the hair bulbs to mature and sprout. In the case of subject “A” (Franklin Kilbert Karbstein), 50 years old, Caucasian, which is a carrier of androgenetic alopecia has been established for at least 25 years at the front area, and 15 years on the back and middle of the scalp, it was found both on the back and in the middle part, the hair grew again vigorously. The result of the action of the extract is evidenced from the 3rd third day of topical cutaneous application, FIG. 7. At this stage, the hair begins to emerge from active hair bulbs. From the third day, the action of the extract appears to be cumulative, and constantly induces the growth of new hair on the treated area, day after day, FIGS. 8, 9 and 10. By the fifth month of treatment, FIG. 11, the area of the scalp is filled almost entirely with hair. The hair strands grow stronger and noticeably better than the hair grown in the area where there was no treatment. The hair strands protrude vigorously up without bending during the first stage of growth, and then they start to bend with the continued growth and action of their weight on their base. The extract promotes the creation of new hair strands.

Method of Preparation

(35) The method of producing the extract of Pteridium Arachnoideum or Pteridium Aquilinum consists of the following steps:

(36) 1. The green or dried leaves and/or stems of the plant Pteridium Arachnoideum or Pteridium Aquilinum may be used, duly crushed.

(37) 2. Place the plant Pteridium Arachnoideum or Pteridium Aquilinum in ethanol solution (which may be any type of ethanol, preferably ethanol 92%, or grain alcohol) and wait a minimum of 26 hours and maximum of 72 hours, when the extract with the active principles is already obtained.
3. The solution color is a deep green, almost like an olive green color.
4. The extract is then filtered, separating the pulp from the liquid.