COMPOSITION FOR IMPROVING THE CELLULITE APPEARANCE OF SKIN

Abstract

The present invention relates to the use by oral route of a composition for oral administration comprising at least one probiotic and at least one B group vitamin, for improvement the cellulite appearance of skin.

Claims

1. A method for improving the cellulite appearance of skin, said method comprising at least one step of administering to a subject by oral route a composition for oral administration comprising at least one probiotic and at least one B group vitamin.

2. The method according to claim 1, wherein said at least one B group vitamin is vitamin B3 and/or vitamin B8.

3. The method according to claim 1, wherein said at least one probiotic is of the species Lactobacillus rhamnosus.

4. The method according to claim 1 for maintaining and/or restoring the biomechanical properties of skin.

5. The method according to claim 1 for maintaining and/or restoring the properties in respect of stretchability, tone, firmness, suppleness, density and/or elasticity of the skin.

6. The method according to claim 1, wherein the subject is not following a weight-reducing diet or slimming diet.

7. A method for improving the cellulite appearance of skin, said method comprising at least one step of administering by oral route, simultaneously, separately or sequentially, to a subject in need thereof, at least one probiotic and at least one B group vitamin.

8. The method according to claim 7, wherein said at least one probiotic and said at least one B group vitamin are administered in the form of a single composition.

9. Method according to claim 8, wherein said composition is administered daily for a period of at least 12 weeks.

10. The method according to claim 7, wherein said subject is not following a weight-reducing diet or slimming diet.

11. The method according to claim 7, wherein said subject is not in a weight loss phase.

12. The method according to claim 7, wherein said at least one probiotic is Lactobacillus rhamnosus NCC 4007 and said at least one B group vitamin is a mixture of vitamin B3 and vitamin B8.

13. The method according to claim 12, wherein said at least one probiotic and said at least one B group vitamin are administered in the form of a composition comprising 1×10.sup.5 to 1×10.sup.12 cfu of Lactobacillus rhamnosus NCC 4007, 4 to 7 mg of a mixture of vitamin B3 and vitamin B8, 50 to 100 mg of FOS and 40 to 80 mg of inulin.

14. The method according to claim 2, wherein said at least one probiotic is of the species Lactobacillus rhamnosus.

15. The method according to claim 2 for maintaining and/or restoring the biomechanical properties of skin.

16. The method according to claim 3 for maintaining and/or restoring the biomechanical properties of skin.

17. The method according to claim 2 for maintaining and/or restoring the properties in respect of stretchability, tone, firmness, suppleness, density and/or elasticity of the skin.

18. The method according to claim 3 for maintaining and/or restoring the properties in respect of stretchability, tone, firmness, suppleness, density and/or elasticity of the skin.

19. The method according to claim 4 for maintaining and/or restoring the properties in respect of stretchability, tone, firmness, suppleness, density and/or elasticity of the skin.

20. The method according to claim 2, wherein the subject is not following a weight-reducing diet or slimming diet.

Description

FIGURES

[0085] FIG. 1 represents the progression of the mean CSS score (Cellulite Severity Score) over the four months of supplementation as described in the example.

[0086] FIG. 2 represents the follow-up of the CSS score between the final month of supplementation (month 4) and the following month, as described in the example.

[0087] FIG. 3 represents the results of a survey among the women who perceived an effect of supplementation, assessing their perception of the effects thereof one month after discontinuation, as described in the example.

EXAMPLE

[0088] The oral composition tested is as follows: Lactobacillus rhamnosus (LPR), fructo-oligosaccharides, chicory root extracts (Cichorium intybus), coating agent (hydroxypropylmethylcellulose), inulin extracted from chicory root (Cichorium intybus), anticaking agents (fatty acid magnesium salts, silicon dioxide); vitamin B3 (niacin), colorants (E171, E172, E133), vitamin B8 (D-biotin). It was tested for 4 months as a daily dose on 34 women between 20 and 45 years of age, not following a diet and having a normal BMI of 23.53±1.94 kg/m.sup.2 at the start of the study. It should be noted that the women taking part in this study did not have any significant weight variation during the study (weight of 64.34±6.62 on average at the start of the study and 65.00±6.59 on average at the end of the study, NS p=0.782), and thus a stable BMI of 23.9 kg/m.sup.2 at the end of the study.

[0089] Each month, the degree of severity of the cellulite on their buttocks was evaluated using the CSS (Cellulite Severity score). This score is obtained by evaluating 5 parameters scored on a scale of 0 to 3 (Hexsel D M et al., A validated photonumeric cellulite severity scale. Journal of the European Academy of Dermatology and Venereology 2009; 23: 523-8).

[0090] These 5 parameters are: [0091] A: The number of visible depressions [0092] B: The depth of the visible depressions [0093] C: The clinical appearances of the lesions studied [0094] D: The presence of flaccidity, lack of firmness or slack skin [0095] E: The grade of cellulite

[0096] The CSS score is equal to the sum of the scores awarded to each parameter. A CSS score of 1 to 5 corresponds to a low degree of cellulite, 6 to 10 to a moderate degree of cellulite, 11 to 15 to a severe degree of cellulite.

[0097] It is observed that taking the dietary supplement enables a significant reduction in the CSS score from the second month (FIG. 1), enabling after four months an average reduction of the CSS score by approximately 1 point. It is noted that this reduction persists further for one month after discontinuing the dietary supplement (FIG. 2).

[0098] Furthermore, the women who observed improvements after four months were surveyed on the persistence of the effects of supplementation one month after the discontinuation thereof. The results are presented in FIG. 3. It is observed that a majority of the women surveyed were of the opinion that, one month after the end of supplementation, the effects on the softness of the skin, the dimpling appearance, the visibility of cellulite, the reduction in the depth of depressions and skin uniformity are still visible.