A NOVEL PROCESS FOR THE PREPARATION OF CONSIDERABLY PURE SILODOSIN

Abstract

The present invention relates to a connector tongue element (1) for an electrical connector plug receptacle (4), the connector tongue element comprising: a flexible printed circuit (10) having an attachment portion (11); connector pins (12) attached and electrically connected to the flexible printed circuit at the attachment portion; and a first body (13) of polymeric material molded around at least a part of the attachment portion to form a connector base portion (14), the first body mechanically secures the attachment of the connector pins to the flexible printed circuit, wherein the connector pins extend from the connector base portion in a withdrawal direction along which an electrical connector plug is adapted to be withdrawn from the electrical connector plug receptacle; wherein the connector pins form a connector tongue portion (16) extending from the connector base portion in the withdrawal direction; and wherein the first body allow the connector pins to present connecting surfaces for connecting the electrical connector plug receptacle to the electrical connector plug.

Claims

1. A process for the preparation of Silodosin represented by Formula 1; ##STR00001## wherein the process comprises the steps of: a) condensing chiral compound represented by Formula (III) ##STR00002## wherein, Bz represents to Benzoyl group with compound represented by Formula (IV) ##STR00003## wherein, Ms represents to Methanesulfonyl group in presence of a base and a phase transfer catalyst: in an organicsolvent to give intermediate represented by Formula (V) ##STR00004## wherein, n is an integer of 1 and 2; b) optionally isolating compound of Formula (V); c) without purification converting compound of Formula (V) to de-protected compound represented by Formula (IX) in an organic solvent; ##STR00005## wherein, n is as defined above; d) optionally isolating compound of Formula (IX); e) without purification converting compound of Formula (IX) to a compound represented by Formula (X) ##STR00006## wherein n is as defined above; f) subjecting compound of Formula (X) to purification by converting to an acid salt for removal of N,N-dialkyl impurity represented by Formula (IIc); ##STR00007## g) hydrolysis of the acid salt formed in step f) to obtain Silodosin of Formula (I).

2. The process according to claim 1, wherein in step a) the organic solvent is selected from the group comprising of benzene, toluene, o-xylene, m-xylene, p-xylene, acetonitrile, dimethyl sulfoxide, methyl isobutyl ketones, dioxane, dimethyl formamide, dimethyl acetamide, N-methyl pyrrolidone and/or mixture thereof, preferably the organic solvent is selected from toluene, dimethyl sulfoxide and mixture thereof.

3. The process according to claim 1, wherein the base is selected from the group comprising of hydroxides, carbonates, alkoxides, phosphates, or mixture thereof.

4. The process according to claim 3, wherein the base is selected from the group comprising of sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, potassium tert-butoxide, sodium tert-butoxide, sodium methoxide, cesium carbonate, or mixture thereof; preferably the base is dipotassium hydrogen phosphate.

5. The process according to claim 1, wherein the phase transfer catalyst is selected from the group comprising of crown ether, triglyme, tetrabutyl ammonium bromide, tetrabutyl ammonium chloride, tetrabutyl ammonium iodide and potassium fluoride; preferably the phase transfer catalyst is tetrabutyl ammonium iodide

6. The process according to claim 1, wherein the condensation step a carried at a temperature ranging from 85-90° C.

7. The process as claimed in claim 1, wherein in step a) the compound of Formula (V) having n=2 is formed in an amount of less than 5%.

8. The process according to claim 1, wherein in step 1, the said acid salt is oxalic acid salt.

9. The process according to claim 1, wherein the compound of Formula (I) obtained in step (g) is isolated with purity≧99.5%.

10. The process according to claim 1, wherein the compound of Formula (I) obtained in step (g) have N,N-dialkyl impurity of Formula (IIc) in an amount of less than0.03% and other individual impurities below 0.1%.

11. A process for purification of crude Silodosin of Formula (X); ##STR00008## wherein, n is an integer of 1 and 2; comprising the steps of; a) coverting crude Silodosin of Formula (X) to its oxalate salt for removal of N,N-dialkyl impurity of Formula (IIc); ##STR00009## b) hydrolysis of the said oxalate salt to get pure Silodosin of Formula (I). ##STR00010##

12. The process according to claim 11, wherein the pure Silodosin of Formula (I) have N,N-dialkyl impurity in an amount less than 0.03% and other individual impurities below 0.1%.

13. The process according to claim 11, wherein the compound of Formula (I) obtained in step (b) is isolated with purity≧99.5%.

Description

BRIEF DESCRIPTION OF DRAWINGS

[0023] FIG. 1 is schematic view a flexible printed circuit with a plurality of contact pins attached and electrically connected thereto.

[0024] FIG. 2a is a schematic view of a connector tongue element for an electrical connector plug receptacle.

[0025] FIG. 2b is a schematic view of a connector tongue element for an electrical connector plug receptacle.

[0026] FIG. 3a illustrates the insertion of the connector tongue element of FIGS. 2a and 2b into a housing of the electrical connector plug receptacle.

[0027] FIG. 3b illustrates the insertion of the connector tongue element of FIGS. 2a and 2b into a housing of the electrical connector plug receptacle.

[0028] FIG. 3c illustrates the insertion of the connector tongue element of FIGS. 2a and 2b into a housing of the electrical connector plug receptacle.

[0029] FIG. 4 illustrates an alternative embodiment of the connector tongue element for an electrical connector plug receptacle.

[0030] FIG. 5 is a block diagram of the producing of the connector tongue element.

DESCRIPTION OF EMBODIMENTS

[0031] The above and other aspects of the present invention will now be described in more detail, with reference to appended drawings showing embodiments of the invention. The figures should not be considered limiting the invention to the specific embodiment; instead they are used for explaining and understanding the invention.

[0032] As illustrated in the figures, the sizes of layers and regions are exaggerated for illustrative purposes and, thus, are provided to illustrate the general structures of embodiments of the present invention. Like reference numerals refer to like elements throughout.

[0033] The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which currently preferred embodiments of the invention are shown. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided for thoroughness and completeness, and to fully convey the scope of the invention to the skilled person.

[0034] FIG. 1 illustrates a flexible printed circuit 10 with a plurality of contact pins 12 attached and electrically connected thereto. The contact pins 12 are attached to the flexible printed circuit 10 at an attachment portion 11 thereof. The flexible printed circuit 10 together with the contact pins 12 provides a starting point for producing a connector tongue element for an electrical connector plug receptacle. The contact pins 12 may e.g. be contact pads. The contact pins 12 may be soldered to the flexible printed circuit 10. However, other methods for attaching the contact pins 12 to the flexible printed circuit may as well be used.

[0035] FIGS. 2a and 2b illustrates a connector tongue element 1 for an electrical connector plug receptacle 4 seen from different perspectives. The connector tongue element 1 comprises the flexible printed circuit 10 with the plurality of contact pins 12 attached and electrically connected thereto from FIG. 1 and a body 15 of polymeric material molded around the attachment portion 11 of the flexible printed circuit 10. The attachment portion 11 of the flexible printed circuit 10, the connector pins 12 and the body 15 integrally form the connector tongue element 1. The body 15 of polymeric material comprises two portions; a first body 13 of polymeric material molded around at least a part of the attachment portion 11 to form a connector base portion 14, and a second body 17 of polymeric material molded along the connector pins 12. The first body 13 mechanically secures the attachment of the connector pins 12 to the flexible printed circuit 10. Moreover, the first body 13, i.e. the connector base portion 14, sealingly connects the flexible printed circuit 10 and the connector pins 12. The second body 17 mechanically secures the connectors pins 12 relative each other. The connector pins 12 are partly embedded in the second body 17. The first and second bodies 15, 17 may be integrally formed.

[0036] FIGS. 3a-3c illustrates the insertion of the connector tongue element 1 of FIGS. 2a and 2b into a housing 2 of the electrical connector plug receptacle 4. The housing 2 may e.g. be formed as a part of a shell of an electrical device comprising the electrical connector plug receptacle 4. From FIGS. 3a-3c it can be seen that the sealing body provided by the connector base portion 14 is adapted to abut a sealing surface extending around a through-opening 3 in the housing 2. When the connector tongue element 1 is inserted into the housing 2 the flexible printed circuit 10 is extending through the through-opening 3. After inserting the connector tongue element 1 into the housing 2 the through-opening 3 may be sealed adding some kind of sealant, e.g. sealing glue.

[0037] FIG. 4 illustrates an embodiment of the connector tongue element 1 for the electrical connector plug receptacle. In this embodiment the connector base portion 14 further comprises electronic circuitry 18. The electronic circuitry 18 is adapted to monitor status of electric connections within the electrical connector plug receptacle. The first body 13 is molded around the electronic circuitry 18. The first body 13 encloses the electronic circuitry 18. By embedding electronic circuitry 18 within the connector base portion 14 space on the flexible printed circuit 10 to be used for other kind of electronic circuitry may be saved. Hence, a smaller flexible printed circuit 10 may be used saving space in the electrical device comprising the electrical connector plug receptacle 4.

[0038] It has been found that there might be a problem with foreign materials, such as water, dust etc., getting into the electrical connector plug receptacle 4. This might create a short circuit within the electrical connector plug receptacle 4. Such short circuits leads to increased temperatures within the electronic device comprising the electrical connector plug receptacle 4 with a potential hazard of fire. The above embodiment embedding electronic circuitry 18 within the connector base portion 14 allow for temperature sensing of the electrical connector plug receptacle 4. By embedding electronic circuitry 18 for sensing the temperature of the electrical connector plug receptacle 4 within the connector base portion 14 otherwise useless space of the flexible printed circuit may be used saving the space on the flexible printed circuit outside the connector base portion 14 for other kind of electronic circuitry. There is also a benefit locating the temperature sensing electronic circuitry in close proximity of the electrical connector plug receptacle 4.

[0039] In FIG. 5 a schematic block diagram illustrating a method of producing the connector tongue element for the electrical connector plug receptacle. The method comprising: attaching 501 connector pins to the flexible printed circuit at an attachment portion of the flexible printed circuit such that the connector pins are electrically connected to the flexible printed circuit at the attachment portion; and molding 502 a first body of polymeric material around at least a part of the attachment portion to form a connector base portion such that the first body mechanically secure the attachment of the connector pins to the flexible printed circuit and such that the first body allow the connector pins to present connecting surfaces for connecting the electrical connector plug receptacle to an electrical connector plug. The method may further comprise molding 503 a second body of polymeric material along the connector pins such that the connectors pins are mechanically secured relative each other. The two steps of molding 502 and 503 may be combined into a single step.

[0040] The person skilled in the art realizes that the present invention by no means is limited to the preferred embodiments described above. On the contrary, many modifications and variations are possible within the scope of the appended claims.

[0041] For example, first and second bodies 15, 17 may be formed as separate bodies.

[0042] Moreover, the electronic circuitry 18 embedded in the first body 15 of polymeric material, i.e. the connector base portion 14, may have other functions as well.

[0043] Additionally, variations to the disclosed embodiments can be understood and effected by the skilled person in practicing the claimed invention, from a study of the drawings, the disclosure, and the appended claims.