CAPSULE ENDOSCOPE, CAPSULE ENDOSCOPIC INSPECTION METHOD, AND CAPSULE ENDOSCOPIC INSPECTION DEVICE
20170360283 · 2017-12-21
Inventors
Cpc classification
H04N23/555
ELECTRICITY
H02J7/00034
ELECTRICITY
H02J2310/23
ELECTRICITY
International classification
A61B1/04
HUMAN NECESSITIES
A61B1/00
HUMAN NECESSITIES
Abstract
A capsule endoscope according to one embodiment includes: a camera; a transceiver; a tubular receiving coil for receiving power supplied from an external power transmitting antenna via magnetic flux; a tubular capsule accommodating these components; and an X-ray marker to be used in location and orientation detection. In the capsule endoscope, a magnetic body is arranged along the inner periphery of the receiving coil, and a self-propelling drive device including an electromagnet and a permanent magnet is arranged in series with the receiving coil along the tubular axial direction of the capsule so that the permanent magnet does not enter the inside of the receiving coil.
Claims
1. A generally cylindrical capsule endoscope to be used for diagnosing the condition of the inside of a tubular organ such as a digestive tract by going into the tubular organ, the capsule endoscope including: a camera which shoots the inside of the tubular organ; a transceiver which performs a wireless communication with the outside; a cylindrical power-reception coil which receives power that is supplied from an external power-transmission antenna via a magnetic flux; a self-propulsion drive device which causes the capsule endoscope to move along the inside of the tubular organ; and a generally cylindrical capsule which houses the above components, wherein a magnetic body is disposed adjoining an inner circumferential surface of the power-reception coil, wherein the self-propulsion drive device has a coil and a magnet, and wherein the self-propulsion drive device is disposed in series to the power-reception coil in an axial direction of the capsule so as not to be located inside the power-reception coil.
2. The capsule endoscope of claim 1, wherein a central portion and both end portions of the capsule are cylindrical and hemispherical, respectively, an outer circumferential surface of the cylindrical portion is formed with a ring-shaped recess, the magnetic body is disposed at the bottom of the recess, the power-reception coil is disposed adjoining an outer circumferential surface of the magnetic body, an outer circumferential surface of the power-reception coil is coated with a coating layer, and the magnetic body and the power-reception coil are housed within a wall thickness of the capsule.
3. (canceled)
4. The capsule endoscope of claim 2, wherein the capsule is 0.5 to 1.0 mm in thickness, the magnetic body is one formed by curling a resin sheet of 100 to 130 in relative permeability and 0.2 to 0.3 mm in thickness containing a ferromagnetic material, and the power-reception coil is a cylindrical coil of 4 to 6.5 mm in coil length formed by winding a coated wire of 0.10 to 0.15 mm in outer diameter around an outer circumferential surface of the magnetic body in two layers.
5. The capsule endoscope of claim 1, wherein a curled electronic circuit board which controls installed devices is disposed in the capsule.
6. The capsule endoscope of claim 1, wherein a central portion and both end portions of the capsule are cylindrical and hemispherical, respectively, an outer circumferential surface of a hemispherical portion that is opposite to an end portion where the camera is disposed is formed with a ring-shaped recess, the magnetic body is disposed at the bottom of the recess, the power-reception coil is disposed adjoining an outer circumferential surface of the magnetic body, and the magnetic body and the power-reception coil are housed in the hemispherical portion of the capsule.
7. The capsule endoscope of claim 6, wherein the magnetic body is one formed by curling a resin sheet of 100 to 130 in relative permeability and 0.1 to 0.5 mm in thickness containing a ferromagnetic material, and the power-reception coil is a cylindrical coil of 3 to 4 mm in coil length formed by winding a coated wire of 0.10 to 0.15 mm in outer diameter around an outer circumferential surface of the magnetic body in three or more layers.
8. The capsule endoscope of claim 1, wherein a liquid chemical supply device is disposed inside the power-reception coil, and includes: a non-metal liquid chemical tank; an electromotive valve or pump which is connected to the liquid chemical tank and driven by power received by the power-reception coil; and a liquid chemical emission opening which is formed at an end portion of the capsule.
9. The capsule endoscope of claim 1, wherein a microhand device is disposed inside the power-reception coil, and device includes: a resin shape-memorized spring which is memorized with an elongated shape at a high temperature and housed in a compressed state at low temperatures; a ceramic heater which heats the resin shape-memorized spring when driven by power received by the power-reception coil; and non-metal (resin or ceramic) scissors which are attached to the tip of the shape-memorized spring, wherein the scissors project from an opening of an end portion of the capsule and open as a result of elongation of the shape-memorized spring that is caused by energization of the ceramic heater, and wherein when the ceramic heater is deenergized, the shape-memorized spring cools and, during that course, the scissors are pulled back and closed as they come to be confined in the opening of the end portion of the capsule.
10. A capsule endoscope examining method including: supplying power intermittently to the power-reception coil of the capsule endoscope of claim 1; detecting a start and an end of a period when the power-reception coil is not supplied with power by a power measurement unit which measures the magnitude of power being received by the power-reception coil or a time measurement unit which operates in synchronism with supply of power to the power-reception coil; and performing a wireless communication with the outside by the transceiver in the period when the power-reception coil is not supplied with power.
11. A capsule endoscope examination instrument which uses a capsule endoscope including: a camera which shoots the inside of a tubular organ; a transceiver which performs a wireless communication with the outside; a cylindrical power-reception coil which receives power that is supplied from an external power-transmission antenna via a magnetic flux; a self-propulsion drive device which causes the capsule endoscope to move along the inside of the tubular organ; and a generally cylindrical capsule which houses the above components, wherein a magnetic body is disposed adjoining an inner circumferential surface of the power-reception coil, wherein the self-propulsion drive device has an electromagnet and a permanent magnet, and wherein the self-propulsion drive device is disposed in series to the power-reception coil in an axial direction of the capsule so that the permanent magnet is not located inside the power-reception coil, the capsule endoscope examination instrument including: the capsule endoscope; and a power-transmission antenna or antennas which supply power wirelessly to the power-reception coil of the capsule endoscope, wherein the power-reception coil comprises a cylindrical coil, and wherein the power-transmission antenna or antennas are ones formed by winding a conductor into a planar spiral.
12. The capsule endoscope examination instrument of claim 11, wherein the capsule endoscope further includes a transmission unit which measures the magnitude of received power and communicates the magnitude of the received power wirelessly wherein the power-transmission antenna or antennas are disposed under and/or over a subject placement part of an examination stage on which a subject is placed so as to be movable relative to the examination stage, wherein the capsule endoscope examination instrument further includes: a receiving unit which receives a signal from the transmission unit of the capsule endoscope; and a power-transmission antenna position controller which arranges the power-transmission antenna or antennas onto a position or positions where the received power becomes larger than or equal to a prescribed value, through a scan by moving the power-transmission antenna or antennas relative to the examination stage.
13. The capsule endoscope examination instrument of claim 11, wherein the capsule endoscope further includes a detector which detects a position and a posture of the capsule, wherein the power-transmission antenna or antennas are disposed under and/or over a subject placement part of the an examination stage on which a subject is placed so as to be moveable independently relative to the examination stage, and wherein the capsule endoscope examination instrument further includes: a receiving unit which receives a signal from a transmission unit of the capsule endoscope; a position determinator which determines a position or positions of the power-transmission antenna or antennas where the power-transmission antenna or antennas allow the received power to be larger than or equal to a prescribed value on the basis of the position and the posture of the capsule endoscope detected by the detector; and a power-transmission antenna position controller which moves the power-transmission antenna or antennas on the basis of a result obtained by the position determinator.
14. The capsule endoscope examination instrument of claim 13, wherein the power-transmission antenna is formed by wind the conductor into the planar spiral to have a circular ring shape having a central hole, and is disposed under or over the subject placement part of the examination stage so that it is movable relative to the examination stage and the axis of the circular ring is perpendicular to the examination stage, and wherein the position determinator and the position controller control such that, if the axis of the power-reception coil is parallel with the axis of the circular ring of the power-transmission antenna, the power-transmission antenna is moved so that the capsule endoscope comes to be located inside an inner edge of the power-transmission antenna, if the axis of the power-reception coil is parallel with a plane that is perpendicular to the axis of the circular ring of the power-transmission antenna, the power-transmission antenna is moved so that the capsule endoscope comes to be located near an outer edge of the power-transmission antenna and the axis of the power-reception coil is directed in a radial direction of the power-transmission antenna, and if the axis of the power-reception coil is inclined with respect to a plane that is perpendicular to the axis of the circular ring of the power-transmission antenna, the power-transmission antenna is moved so that the capsule endoscope comes to be located in a region of the circular ring between the inner edge and the outer edge of the power-transmission antenna and the axis of the power-reception coil is directed in the radial direction of the power-transmission antenna.
15. The capsule endoscope examination instrument of claim 13, wherein the power-transmission antennas are formed by winding the conductor into the planar spiral to have a circular ring shape having a central hole, and include a first power-transmission antenna and a second power-transmission antenna that are disposed under and over the subject placement part of the examination stage, respectively, so that they are movable relative to the examination stage and the axis of the circular ring is perpendicular to the examination stage, and wherein the position determinator and the position controller control such that, if the axis of the power-reception coil is parallel with the axis of the circular ring of each of the first and second power-transmission antennas, the first and second power-transmission antennas are arranged coaxially, moved so that the capsule endoscope comes to be located inside an inner edge of each of the first and second power-transmission antennas, and supplied with power wirelessly so as to generate respective magnetic fields that are in the same direction, if the axis of the power-reception coil is parallel with a plane that is perpendicular to the axis of the circular ring of each of the first and second power-transmission antennas, the first and second power-transmission antennas are arranged coaxially, moved so that the capsule endoscope comes to be located in a region between the respective circular rings bounded by the inner edges and the outer edges of the first and second power-transmission antennas, and supplied with power wirelessly so as to generate respective magnetic fields that are in opposite directions, and if the axis of the power-reception coil is inclined with respect to a plane that is perpendicular to the axis of the circular ring of each of the first and second power-transmission antennas, the first and second power-transmission antennas are deviated from each other so that their central holes overlap with each other, moved so that the capsule endoscope comes to be located in a region of an overlap of the circular rings of the first and second power-transmission antennas, and supplied with power wirelessly so as to generate respective magnetic fields that are in opposite directions, or the first and second power-transmission antennas are deviated from each other so that their central holes do not overlap with each other, moved so that the capsule endoscope comes to be located in a region of an overlap of the circular rings of the first and second power-transmission antennas, and supplied with power wirelessly so as to generate respective magnetic fields that are in the same direction.
16. The capsule endoscope of claim 6, wherein the power-reception coil is formed by winding a coated wire on an outer circumferential surface of the magnetic body, such that the number of winding turns is large at an end of the capsule where the camera is disposed, and becomes lesser toward an opposite end to the end where the camera is disposed.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
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MODES FOR CARRYING OUT THE INVENTION
[0168] Capsule endoscopes according to embodiments of the present invention will be hereinafter described with reference to the drawings. The drawings are schematic ones, and the shapes, the ratios between dimensions, etc. in the drawings are not exactly the same as real ones. The same members etc. are given the same symbol and descriptions therefor may be omitted.
[Capsule Endoscope]
[0169] The configuration of a capsule endoscope will be described below in a specific manner.
[0170]
[0171] The capsule endoscope 100a can go into tubular organs such as the digestive organs, move inside the tubular organs using the self-propulsion drive device 50, shoot the inside of the tubular organs using the camera 14, and administer a liquid chemical using the liquid chemical supply device 40a.
[0172] The capsule 11a is composed by connecting the hemispherical tip cover 12 formed by a transparent member and the generally cylindrical capsule barrel 13a having the hemispherical end portion and has a hermetic structure prevent the camera 14, the illumination device 15 and the semiconductor devices 16 from coming into contact with liquid. It is preferable that the outer size and the length of the capsule 11a be about 9 to 12 mm and about 20 to 30 mm, respectively. The capsule 11a is difficult to ingest if its size or length exceeds this range, and it is difficult to incorporate the necessary members in the capsule 11a if its size or length is smaller than this range.
[0173] The camera 14 is mounted on the electronic circuit board 17 together with the illumination devices 15 so that it is adjacent to the tip cover 12 and the tip of its lens is directed to the tip cover 12 and that it can thus shoot the outside through the transparent tip cover 12. Composed of the lens and a solid-state imaging device, the camera 14 can convert an image formed by performing photoelectric conversion on it. No particular limitations are imposed on the type of the solid-state imaging device; specific examples are a CCD (charge-coupled device) image sensor and a CMOS (complementary metal-oxide-semiconductor) image sensor.
[0174] The illumination devices 15 are used for illuminating a shooting target of the camera 14 to make it brighter. It is preferable that the illumination devices 15 be of a power saving type; more specifically, the use of white light-emitting diodes is preferable.
[0175] The electronic circuit board(s) 18a is mounted with the semiconductor devices 16 having such functions as signal processing, wireless communication, and power control. The electronic circuit board(s) 18a may be a common circuit board(s) made of an epoxy resin or be made of a flexible material and wound into a tubular shape. Alternatively, the electronic circuit board(s) 18a may be divided into plural boards or, conversely, be integral with the electronic circuit board 17. There are no particular limitations on the installation place of the electronic circuit board(s) 18a; for example, it may be disposed inside the power-reception coil 20a. The amounts of conductive materials used in the electronic circuit board(s) 18a are very small and hence no eddy current large enough to affect the power reception efficiency is generated there.
[0176] In the capsule endoscope 100a, the power-reception coil 20a is a cylindrical coil that is a winding of a coated wire. For example, the power-reception coil 20a may be a hollow coil of 9 mm in outer diameter (smaller than the inner diameter of the capsule 11a) and 6 mm in inner diameter that is formed by winding, into a cylindrical shape, a coated wire of 0.3 mm in outer diameter and 2 m in length that has a copper core wire of 0.1 mm in diameter and a thick insulating coating layer. The coated wire may be wound either clockwise or counterclockwise and may have some disorder in winding form. To avoid cancellation between magnetic field components, it is preferable wind the coated wire entirely in the same direction and in order.
[0177] In the capsule endoscope 100a, the magnetic body 30a may be disposed inside the power-reception coil 20a. No particular limitations are imposed on the magnetic body 30a; it is preferable that the magnetic body 30a be a member that is shaped into a cylindrical form and made of a ferromagnetic material such as ferrite, cobalt, iron, iron oxide, chromium oxide, or nickel, and it is particularly preferable that the magnetic body 30a be a member produced by curling, by one turn, a resin sheet of 0.1 to 0.5 mm in thickness containing ferrite. When produced by curling a ferrite resin sheet, the magnetic body 30a is high in magnetic flux density at the inner surface of the power-reception coil 20a. Thus, when the magnetic body 30a is used, the received power (power value) is 15 times (thickness 0.1 mm), 21 times (0.2 mm), and 25 times (0.5 mm) as large as that of a case that no magnetic body is used. Where the magnetic body 30a is formed using a thin ferrite resin sheet, a wide space in which various members can be placed and used effectively is formed inside the power-reception coil 20a.
[0178] In the capsule endoscope 100a, the space inside the power-reception coil 20a can be utilized effectively by disposing a non-metal (resin or ceramic) liquid chemical tank 41a there. Since the liquid chemical tank 41a is made of a non-metal, no eddy current to cause reduction in power reception efficiency is generated there. The liquid chemical supply device 40a is composed of the liquid chemical tank 41a, a liquid chemical suction pipe 42 which is inserted in the liquid chemical tank 41a, an electromotive valve or pump 43 which is driven by power received by the power-reception coil 20a, and a liquid chemical emission opening 44 which is formed at one end of the capsule 11a. Since the electromotive valve or pump 43 can be driven by a control signal that is supplied externally, a liquid chemical can be administered at a desired time and place.
[0179] The capsule endoscope 100a makes it possible to examine a wide range in a short time because it is equipped with the self-propulsion drive device 50 and hence can move inside tubular organs and shoot the inside of them. There are no particular limitations on the self-propulsion drive device 50. For example, an actuator having an electromagnet and a permanent magnet can be used in which electric power obtained by the power-reception coil 20a is used as a motive power source, that is, a magnetic field is generated by causing a current to flow through a coil (to serve as the electromagnet) wound on a cylindrical case and a rod magnet (permanent magnet) placed inside the case is thereby caused to collide with a wall surface strongly that is located on the destination side in its movement direction to obtain propulsion (the rod magnet is returned slowly by causing a weak reverse current through the coil). However, since the self-propulsion drive device 50 includes the magnetic members and the conductive member (coil), it is not preferable that the self-propulsion drive device 50 is disposed inside the power-reception coil 20a. Not to impair the magnetic flux density enhancing effect of the magnetic body 30a which is disposed adjoining the inner circumferential surface of the power-reception coil 20a, it is preferable that the self-propulsion drive device 50 be disposed in series to the power-reception coil 20a along the axial direction of the capsule 11a so that the self-propulsion drive device 50 (more specifically, at least the permanent magnet) does not enter the inside of the power-reception coil 20a.
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[0181] The microhand device 60 is composed of a resin shape-memorized spring 61 which is memorized with an elongated shape at a high temperature and housed in a compressed state at low temperatures, a ceramic heater 62 for heating the resin shape-memorized spring 61, non-metal (resin or ceramic) scissors 63 which are attached to the tip of the shape-memorized spring 61, and a resin spring 64 for opening the scissors 63. The microhand device 60 can be driven by power received by the power-reception coil 20b. Since all of the components of the microhand device 60 are made of non-metal materials, the microhand device 60 does not lower the power reception efficiency even if it is disposed in the inside space of the power-reception coil 20b. Thus, the capsule 11b can be miniaturized by utilizing the inside space of the power-reception coil 20b effectively.
[0182] How the microhand device 60 operates will be described with reference to
[0183] Since the microhand device 60 employed in the invention uses sufficient power that is received efficiently and has a simple structure that the scissors 63 are opened and closed by energizing and deenergizing to the ceramic heater 62, respectively, the microhand device 60 has features that they are small and hard to fail. Furthermore, capable of being driven by an external control signal, the microhand device 60 can take a sample at a desired time and place.
[0184] The capsule endoscope according to the invention may be equipped with X-ray markers for detection of a position and a posture at at least two locations in its longitudinal direction. For example, as shown in
[0185]
[0186] In the embodiment, a power-reception coil 20c and a magnetic body 30c are provided within the wall thickness of the generally cylindrical capsule barrel 13c. With this structure, the inside space of the power-reception coil 20c can be made wider and utilized more efficiently than in the capsule endoscope 100a shown in
[0187] A self-propulsion drive device 50, a liquid chemical supply device 40c, and a capacitor 80 are disposed in this order inside the capsule barrel 13c. The self-propulsion drive device 50 is composed of high permeability members and conductive members.
[0188] The capacitor 80 is equipped with conductive electrode members. It is therefore not preferable to dispose each of the self-propulsion drive device 50 and the capacitor 80 inside the power-reception coil 20c. Not to impair the magnetic flux density enhancing effect of the magnetic body 30c which is disposed adjoining the inner circumferential surface of the power-reception coil 20c, it is preferable that each of the self-propulsion drive device 50 and the capacitor 80 be disposed in series to the power-reception coil 20c. Since the liquid chemical supply device 40c is composed of non-metal members and hence do not affect a magnetic flux, it is disposed inside the power-reception coil 20c. An electronic circuit board(s) 18a which is mounted with semiconductor devices 16 is disposed in the gap between the generally cylindrical capsule barrel 13c and the self-propulsion drive device 50.
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[0190] There are no particular limitations on the dimensions of the individual portions relating to the power-reception coil 20c. For example, preferable modes are as follows.
[0191] To secure necessary mechanical strength, it is preferable that the thickness do of the capsule barrel 13c be 0.8 to 1.0 mm and the thickness d.sub.1 of wall of the recess 13c1 be larger than or equal to 0.2 mm. It is preferable that the magnetic body 30c be a cylindrical magnetic body of 0.2 to 0.3 mm in thickness d.sub.2 formed by curling a resin sheet (e.g., ferrite resin sheet) of 100 to 130 in relative permeability and 0.2 to 0.3 mm in thickness containing a ferroelectric material. It is preferable that the power-reception coil 20c be a cylindrical coil of 0.24 to 0.3 mm in thickness d.sub.3 and 4 to 6.5 mm in coil length I formed by winding a coated wire of 0.10 to 0.15 mm in outer diameter around the outer circumferential surface of the magnetic body 30c in two layers. It is preferable that the outer circumferential surface of the power-reception coil 20c be coated with a coating layer 23c made of a resin or the like. Although there are no particular limitations on the thickness d.sub.4 of the coating layer 23c, it is preferable that, for example, the thickness d.sub.4 be set so that no steps are formed in the capsule surface to reduce frictional resistance and allow a subject to swallow the capsule endoscope 100c more easily.
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[0193] Capable of having a wider space than the capsule endoscope 100a which is equipped with the inside power-reception coil 20a, the capsule endoscope 100c of the above mode which is equipped with the outside power-reception coil 20c can be equipped with, for example, a larger liquid chemical tank.
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[0195] In the embodiment, a power-reception coil 20d and a magnetic body 30d are disposed in the hemispherical end portion of the capsule barrel 13d. With this configuration, it is possible to employ, as a place to dispose the power-reception coil 20d and the magnetic body 30d, the hemispherical end portion whose free space is difficult to use and to dispose high permeability members and conductive members in a desired manner in the inside space of the cylindrical portion of the capsule barrel 13d.
[0196] Inside the cylindrical portion of the capsule barrel 13d, an electronic circuit board(s) 18a which is mounted with semiconductor devices 16 is disposed in the gap between a self-propulsion drive device 50 and the capsule barrel 13d and two electronic circuit boards 18b which are mounted with semiconductor devices 16 are disposed behind the electronic circuit board 17 which is mounted with the camera 14 and the illumination devices 15. Two large capacity capacitors 80 are disposed behind the self-propulsion drive device 50 to enable supply of more electricity.
[0197]
[0198] There are no particular limitations on the dimensions of the individual portions relating to the power-reception coil 20d. For example, preferable modes are as follows.
[0199] There are no particular limitations on the diameter (coil diameter) D.sub.C1 of the cylindrical constricted portion of the ring-shaped recess 13d1 of the capsule barrel 13d. However, since the length I of the ring-shaped recess 13c1 (coil length) becomes shorter as the diameter D.sub.C1 increases, it is preferable that the diameter D.sub.C1 be about ½ of the outer diameter D.sub.C0 of the cylindrical portion of the capsule barrel 13c. For example, the coil length I may be made 4 mm when the coil diameter D.sub.C1 is set at 5 mm for D.sub.C0 being equal to 11 mm.
[0200] It is preferable that the magnetic body 30d be a cylindrical magnetic body of 0.1 to 0.5 mm in thickness d.sub.2 formed by curling a resin sheet (e.g., ferrite resin sheet) of 100 to 130 in relative permeability and 0.1 to 0.5 mm in thickness containing a ferroelectric material. It is preferable that the power-reception coil 20d be a cylindrical coil of 3 to 4 mm in coil length I formed by winding a coated wire of 0.10 to 0.15 mm in outer diameter around the outer circumferential surface of the magnetic body 30d in three or more layers.
[0201] As shown in
[0202]
[0203] Alternatively, as shown in
[0204] Next, an example system configuration of a capsule endoscope 100 according to the invention will be described with reference to
[0205] The rectification/voltage conversion unit 16a converts AC power received by an LC resonance circuit that is a series connection of the power-reception coil 20 and the resonance capacitor 25 into DC power of a prescribed voltage and supplies the latter to the capacitor 80 and the power source control unit 16b. For example, as shown in
[0206] The capacitor 80 has a role of suppressing a voltage variation by storing charge. It is preferable that the capacitor 80 be small and of a large capacity; for example, an electric double-layer capacitor is used preferably. The capacitor 80 may be replaced by a storage battery such as a lithium-ion secondary battery.
[0207] The power source control unit 16b is equipped with a voltage regulation circuit (linear regulator), a power source protection circuit, a reference voltage circuit, an oscillation circuit, etc., and has roles of stable supply of power, monitoring, shutting-off, reference voltage/clock generation. To generate a highly accurate clock signal wave and carrier wave for wireless communication, it is desirable that the power source control unit 16b be connected to the vibrator 90 such as a quartz vibrator or a ceramic vibrator.
[0208] The received power measuring unit 16c can measure the magnitude of AC power received by the power-reception coil 20 in the form of the magnitude of a DC voltage obtained by the rectification/voltage conversion unit 16a through conversion of the AC power.
[0209] The received power indication signal processing/reception unit 16d can encode the magnitude of measured received power into a digital signal and send the latter from the transmission/reception antenna 16h.
[0210] The control signal reception/processing unit 16e can receive, via the transmission/reception antenna 16h, a control signal transmitted from the outside, decode it, and send a resulting signal to the annexed devices control unit 16f.
[0211] The annexed devices control unit 16f can control the camera 14, the illumination devices 15, the self-propulsion drive device 50, the liquid chemical supply device 40, and the microhand device 60.
[0212] The image signal processing/transmission unit 16g can perform signal processing on an image signal taken by the camera 14 and send a resulting signal to the outside via the transmission/reception antenna 16h.
[Capsule Endoscope Examining Method]
[0213] In the capsule endoscope 100 according to the invention, the power-reception coil may be supplied with power continuously. Alternatively, as described below, it may be supplied with power intermittently.
[0214] For example, where there is concern that continuous operation of the self-propulsion drive device 50 may cause temperature increase in the capsule endoscope 100, the power-reception coil 20 may be supplied with power intermittently in the following manner. During power supply periods (power supply on periods), the capsule endoscope 100 is caused to move on its own by energizing the self-propulsion drive device 50. During non-power-supply periods (power supply off periods), the capsule endoscope 100 is allowed to cool by deenergizing the self-propulsion drive device 50.
[0215] Where there is concern that a communication error may occur due to electromagnetic noise during power supply on periods, the power-reception coil 20 may be supplied with power intermittently in the following manner During power supply off periods, the transmission/reception units 16d, 16e, and 16g are allowed to communicate with the outside. During power supply on periods, wireless communications are suspended.
[0216] A start and an end of a power supply off period can be detected by a power measurement unit to measure the magnitude of power received by the power-reception coil or a time measurement unit that operates in synchronism with supply of power to the power-reception coil 20. More specifically, the received power measuring unit 16c can be provided as a unit to measure the magnitude of received power and the power control unit 16b having a counter circuit for counting clocks can be provided as a time measurement unit that operates in synchronism with supply of power to the power-reception coil 20. Using these units, the capsule endoscope 100 can be controlled in synchronism with intermittent supply of power by detecting a start and an end of a power supply off period.
[0217] An example manner of intermittent supply of power will be described below in detail with reference to the related drawings.
[0218] Part (a) of
[0219] Part (b) of
[0220] Supply of power is turned on at time t.sub.1. Received AC power is rectified by the diode bridge 16aa and boosted to 6 V by the booster circuit 16ab, and a resulting voltage is supplied to the capacitor 80. Although the terminal voltage of the capacitor 80 increases in proportion to the amount of charge stored therein, the internal power source voltage is clamped at 3.3 V by the linear regulator (at time t.sub.2). On the other hand, the terminal voltage of the capacitor 80 is saturated after being increased to 6 V which is equal to the output voltage 6 V of the booster circuit 16ab. At time t.sub.3, the supply of power is turned off and the terminal voltage of the capacitor 80 starts to decrease. However, since the internal power source voltage is clamped at 3.3 V by the linear regulator, it is kept at 3.3 V until time t.sub.4. When the terminal voltage of the capacitor 80 has become lower than 3.3 V, the internal power source voltage also starts to decrease and reaches, at time t.sub.5, a lower limit voltage UV under which the semiconductor device 16 is rendered non-operational. However, if the circuit is not shut down, the internal power source voltage continues to decrease. At time t.sub.6, supply of power is turned on again, whereupon charging of the capacitor 80 is started. The same operation as described above is repeated thereafter.
[0221] The internal power source voltage is kept at 3.3 V from time t.sub.2 to time t.sub.4. For example, operations are possible that from time t.sub.2 to time t.sub.3 the capsule endoscope 100 is allowed to move on its own by supplying power to the self-propulsion drive device 50 while charging the capacitor 80, and that from time t.sub.3 to time t.sub.4 the inside of the digestive tract is shot and an image signal is transmitted to the outside by a wireless communication by supplying power stored in the capacitor 80 to the camera 14, the illumination units 15, and the image signal processing/transmission unit 16g. Control signals can be sent and received in the period of time t.sub.3 to time t.sub.4.
[0222] From the viewpoint of the stability of circuit operations, it is desirable to back up the power source by providing a reverse blocking diode and an auxiliary capacitor (neither shown in
[Capsule Endoscope Examination Instrument]
[0223]
[0224] In the capsule endoscope examination instrument 200 according to the invention, there are no particular limitations on the power-transmission antennas 2a and 2b; for example, each of them may be a coil formed by winding a conductor in spiral form or a coil formed by winding a conductor in cylindrical form. Since the position and the posture of the capsule endoscope 100 vary from time to time as the digestive tract makes a vermicular movement, it is preferable that the power-transmission antennas 2a and 2b generate a magnetic field capable of accommodating various positions and postures. The power reception efficiency can be maximized by disposing the power-transmission antennas 2a and 2b so that the axis of the cylindrical power-reception coil 20 coincides with the direction of the magnetic field.
[0225] Either both or one of the power-transmission antennas 2a and 2b may be provided. Although even one of the power-transmission antennas 2a and 2b enables efficient supply of power if a proper position control is made, a wide region where the strength and the direction of a magnetic field are uniform can be obtained by using both power-transmission antennas 2a and 2b, in which case the supply of power is stabilized.
[0226] The manipulators 3a and 3b are capable of moving the power-transmission antennas 2a and 2b to positions where they maximize the power reception efficiency.
[0227] The AC power source 4 is capable of supplying AC power to the power-transmission antennas 2a and 2b and is composed of a frequency generator, a DC power source, and an inverter. The frequency of AC power is preferably 50 to 500 kHz, even preferably 100 to 200 kHz, and particularly preferably 150 kHz. Frequencies lower than 50 kHz are not preferable because the overall transmission efficiency is low and it is difficult to obtain a long transmission distance. Frequencies higher than 500 kHz are not preferable because a drive circuit is costly, the driver efficiency is low, and attenuation in a human body is large.
[0228] When necessary, the capsule endoscope examination instrument 200 according to the invention may be equipped with an X-ray marker position detector 9 (not shown; see
(Example System Configuration 1)
[0229]
[0230] In this capsule endoscope examination instrument 200a, the control unit 5 can be equipped with a control signal processing/transmission unit 5a, a received power indication signal reception/processing unit 5b, an image signal reception/processing unit 5c, a manipulator control unit 5d, and a storage disc 5e. The transmission/reception antenna 6, the manipulation unit 7, the display unit 8, and the manipulators 3a and 3b can be connected to the control unit 5.
[0231] In the manipulation unit 7, a control signal that has been input through a keyboard, a mouse, a switch, or a lever can be encoded by the control signal processing/transmission unit 5a and sent from the transmission/reception antenna 6, whereby the camera 14, the illumination devices 15, the liquid chemical supply device 40, the self-propulsion drive device 50, the microhand device 60, etc. of the capsule endoscope 100 can be manipulated remotely. An image signal that is transmitted from the capsule endoscope 100 by a wireless communication can be received by the transmission/reception antenna 6, and decoded by the image signal reception/processing unit 5c into image data, which can be displayed on the display unit 8 or stored in the storage disc 5e.
[0232] A received power indication signal for notification of the magnitude of power received by the capsule endoscope 100 can be received by the transmission/reception antenna 6, decoded by the received power indication signal reception/processing unit 5b, and sent to the manipulator control unit 5d. The manipulator control unit 5d can perform a scan by moving the power-transmission antenna 2a and/or 2b relative to the examination stage 1 and stop the scan at a position where the power-transmission antenna 2a and/or 2b allows the received power indication signal to be larger than or equal to a prescribed value, preferably, take a maximum value. The sentence “the received power indication signal is larger than or equal to the prescribed value” means that it is larger than or equal to necessary received power.
[0233] In the above mode, the power-transmission antenna 2a and 2b can be positioned so that a received power indication signal becomes larger than or equal to the prescribed value, preferably, takes a maximum value, irrespective of where the capsule endoscope 100 is located.
[0234] However, in this system configuration, it takes a certain time to perform a scan to find a power supply position where to allow a received power indication signal to take a maximum value. Whereas the position of the capsule endoscope 100 is not changed quickly by a vermicular movement of the digestive tract, its posture may vary frequently. Since a scan needs to be performed almost from the start if the posture has been changed by close to 90°, this example configuration tends to be lower in efficiency than the following example configuration 2.
(Example System Configuration 2)
[0235]
[0236] However, in this case, the capsule endoscope 100 is equipped with X-ray markers at at least two position in the longitudinal direction in addition to the system configuration shown in
[0237] This capsule endoscope examination instrument 200b is additionally equipped with an X-ray marker position detector 9 and a power-transmission antenna optimum arrangement calculation unit 5f.
[0238] A position and a posture of the capsule endoscope 100 detected by the X-ray marker position detector 9 are input to the antenna optimum arrangement calculation unit 5f, which calculates positions of the power-transmission antennas 2a and 2b where the power-transmission antennas 2a and 2b allow received power to become larger than or equal to a prescribed value, preferably, take a maximum value. The manipulator control unit 5d can set the power-transmission antennas 2a and 2b at optimum positions by moving the manipulators 3a and 3b on the basis of calculation results. The sentence “the received power is larger than or equal to the prescribed value” means that it is larger than or equal to necessary received power.
[0239] Although the received power indication signal reception/processing unit 5b which receives and decodes a signal for notification of the magnitude of received power is left as an auxiliary function to enable monitoring of a power reception state, it is not connected to the power-transmission antenna optimum arrangement calculation unit 5f and does not relate to the position control directly (in this mode, the received power indication signal reception/processing unit 5b is not indispensable).
[0240] In the above mode, a position and a posture of the capsule endoscope 100 are detected using the X-ray markers and the power-transmission antennas 2a and 2b can be placed so that the received power becomes larger than the prescribed value, preferably a maximum value irrespective of whether the capsule endoscope 100 is located at any position. As a result, even when the capsule endoscope 100 has changed its posture suddenly, stable endoscope examination can be performed by securing necessary received power by moving the power-transmission antennas 2a and 2b efficiently.
[Power-Transmission Antenna]
[0241]
[0242] The power-transmission antenna 2 is formed by winding a conductor spirally in a plane and has a ring shape having a central hole. When the power-transmission antenna 2 is supplied with AC power, a divergent magnetic field can be formed which diverges outward from the central hole. This mode enables efficient supply of power because the power-transmission antenna 2 can be placed so that magnetic field lines become parallel with the axis of the cylindrical power-reception coil irrespective of where the capsule endoscope 100 is located at any position. In the invention, it is appropriate the size of the power-transmission antenna 2 be approximately the same as the width of a human body; it is preferable that the outer diameter Do be 200 to 500 mm, the inner diameter Di be 40 to 300 mm, and the ratio of the inner diameter Di to the outer diameter Do be 0.2 to 0.6. There are no particular limitations on the wire to constitute the power-transmission antenna 2; common wires can be used in which a copper core wire is covered with an insulating coating layer. However, if the interval between adjoining core wires is too small, it is difficult to form a strong magnetic field due to mutual interference; it is preferable that the gap between an nth turn and an (n+1)th turn be in a range of 0.2d to 2d where d is the diameter of the wire. For example, this condition is satisfied when a wire of 2 mm in outer diameter having a copper core wire of 1 mm in diameter and a thick insulating coating layer is used. It suffices that a wire be wound in one direction, that is, a wire may be wound either clockwise or counterclockwise.
[0243] The power-transmission antenna 2 may be such that plural planar, spiral windings of a wire are stacked in such a manner that in a sectional view the wires belonging to the respective layers are arranged in a staggered manner. A strong magnetic field can be generated by increasing the number of turns of the antenna 2; the strength of the magnetic field is proportional to the number of turns.
[Magnetic Field Generated by Power-Transmission Antenna]
[0244] Next, a mode of a magnetic field generated by the above-described antenna (the planar, spiral antenna having a central hole) will be described in a specific manner on the basis of an electromagnetic field simulation result.
[0245] An example will be described below in which directions and strengths of a magnetic field to be generated when an energization current of 1 A is caused to flow through a planar, spiral power-transmission antenna having a central hole (Di/Do=(about 80 mm)/(about 240 mm); (number of turns)=10) were calculated.
[0246]
[0247]
[0248] In the X-axis direction in
[0249] It is therefore preferable to set the power-transmission antenna 2 as close to the body of a subject as possible (i.e., priority is given to securing of a strong magnetic field) and to accommodate attenuation of magnetic field strength in the horizontal direction by moving the power-transmission antenna 2 in the horizontal direction.
[0250] As shown in
[0251]
[0252] In
[Power-Transmission Antenna Placing Method]
[0253] First, a power-transmission antenna placing method will be described briefly using a two-dimensional model.
[0254] In
[0255] Next, a description will be made of a method for placing the power-transmission antenna at a most appropriate position three-dimensionally according to a position and a posture of the capsule endoscope 100.
[0256] For three-dimensional consideration, the Y axis that extends in the left-right direction of the body of the subject P is set in addition to the X axis that extends from the head top to the foot and the Z axis that is perpendicular to the subject placement surface 1a of the examination stage. In this coordinate system, the posture of the capsule endoscope 100 is expressed by the azimuth angle αw with respect to the X axis of a projected image obtained by projecting the axis of the cylindrical capsule endoscope 100 onto the XY plane and the inclination angle βc of the axis of the cylindrical capsule endoscope 100 with respect to the Z axis.
[0257] A position (Xc, Yc, Zc) of the center of the power-reception coil 20 and a posture (αc, βc) of the power-reception coil 20 can be known using the capsule endoscope examination instrument 200b which is equipped with the X-ray marker position detector 9.
[0258]
[0259] At step S1, positions of the X-ray markers of the capsule endoscope 100 is detected by the X-ray marker position detector 9. Pieces of position information of the respective X-ray markers can be input to the antenna optimum arrangement calculation unit 5f of the control unit 5 of the capsule endoscope examination instrument 200b from the X-ray marker position detector 9.
[0260] At step S2, the antenna optimum arrangement calculation unit 5f calculates a center position (Xc, Yc, Zc) of the power-reception coil 20 on the basis of the positions of the X-ray markers.
[0261] At step S3, the antenna optimum arrangement calculation unit 5f calculates an inclination angle of the power-reception coil 20 on the basis of the positions of the X-ray markers. Since the axis of the cylindrical capsule endoscope 100 coincides with the axis of the cylindrical power-reception coil 20, an inclination of the power-reception coil 20 can be calculated easily below on the basis of an inclination of the capsule endoscope 100. The two angular parameters αc and βc exist as parameters that represent the inclination of the power-reception coil 20. The parameter αc is the azimuth angle of the power-reception coil 20 with respect to the X axis when it is projected onto the XY plane, and βc is the inclination angle of the power-reception coil 20 with respect to the Z axis.
[0262] At step S4, the antenna optimum arrangement calculation unit 5f calculates a target center position O′ of the power-transmission antenna 2.
[0263] A procedure for calculating a target center position O′ is as follows.
[0264] First, consideration is given to a first movement for registering the center of the power-transmission antenna 2 with the center (Xc, Yc, Zc) of the power-reception coil 20. In a state that the center registration has been made, the three-dimensional space is cut by a plane (having the azimuth angle αc) that is parallel with the axis of the cylindrical power-reception coil 20. A magnetic field isoclinic line diagram as shown in
[0265] Where a Zs coordinate of a target center position O′ (Xs, Ys, Zs) is fixed, an Xs coordinate and a Ys coordinate of the target center position O′ are determined uniquely. However, where a Zs coordinate of a target center position O′ (Xs, Ys, Zs) is variable, a target center position O′ is not determined uniquely for βc and plural positions satisfy the conditions. However, changing the Zc coordinate in such direction that the power-transmission antenna 2 goes away from the subject P is not preferable because it weakens the magnetic field. Unless there is a special reason to the contrary, it is better to fix the power-transmission antenna 2 at a position that is as close to the subject P as possible. The special reason means that the body of the subject P is so thick that the capsule endoscope 100 is distant too much from the subject placement surface 1a in the Z direction. However, in this case, it is preferable to use the abdomen-side power-transmission antenna 2b rather than the back-side power-transmission antenna 2a. Thus, practically, there is almost no need for a position adjustment involving the Zc coordinate.
[0266] As soon as a target center position O′ of the power-transmission antenna 2 is calculated, at step S5 a calculation result is set to the manipulator control unit 5d and the power-transmission antenna 2a or 2b is moved to the target center position O′ by the manipulator 3a or 3b.
[0267] Specific descriptions will be made below by assuming various relative positional relationships in the three-dimensional space.
[0268]
[0269] As described above, when the axis of the cylindrical power-reception coil 20 is parallel with a plane that is perpendicular to the axis of the power-transmission antenna 2, the power-transmission antenna 2 is moved so that the capsule endoscope 100 comes to be located near the outer edge of the power-transmission antenna 2 and the axis of the cylindrical power-reception coil 20 is directed in a radial direction of the power-transmission antenna 2.
[0270]
[0271] As described above, when the axis of the cylindrical power-reception coil 20 is parallel with the axis of the power-transmission antenna 2, the power-transmission antenna 2 is moved so that the capsule endoscope 100 comes to be located inside the inner edge of the power-transmission antenna 2.
[0272]
[0273] As described above, when the axis of the cylindrical power-reception coil 20 is inclined from a plane that is perpendicular to the axis of the power-transmission antenna 2, the power-transmission antenna 2 is moved so that the capsule endoscope 100 comes to be located in the ring portion between the inner edge and the outer edge of the power-transmission antenna 2 and the axis of the cylindrical power-reception coil 20 is directed in a radial direction of the power-transmission antenna 2.
[0274]
[0275] As described above, when the axis of the cylindrical power-reception coil 20 is parallel with a plane that is perpendicular to the axis of the power-transmission antenna 2, the power-transmission antenna 2 is moved so that the capsule endoscope 100 comes to be located near the outer edge of the power-transmission antenna 2 and the axis of the cylindrical power-reception coil 20 is directed in a radial direction of the power-transmission antenna 2.
[0276] Next, a description will be made of a wireless power supply method that increases the power supply amount using the two power-transmission antennas 2a and 2b.
[0277]
[0278] Where the power-transmission antennas 2a and 2b are formed by winding a wire in opposite directions, the same results as described above are obtained by forming magnetic fields in the same direction by deviating the phases of AC powers applied to them by a half cycle.
[0279] As described above, when the axis of the cylindrical power-reception coil 20 is parallel with the axis of each of the power-transmission antennas 2a and 2b, it is appropriate to arrange the first power-transmission antenna and the second power-transmission antenna coaxially, move them so that the capsule endoscope 100 is placed inside the inner edges of the respective power-transmission antennas, and perform wireless supply of power in such a manner that the first power-transmission antenna and the second power-transmission antenna generate magnetic fields in the same direction.
[0280]
[0281] Where the power-transmission antennas 2a and 2b are formed by winding a wire in opposite directions, the same results as described above are obtained by forming magnetic fields in opposite directions by setting the phases of AC powers applied to them identical.
[0282] As described above, when the axis of the cylindrical power-reception coil 20 is parallel with a plane that is perpendicular to the axis of each of the power-transmission antennas 2a and 2b, it is appropriate to arrange the first power-transmission antenna and the second power-transmission antenna coaxially, move them so that the capsule endoscope 100 is placed in a region between the ring portions each of which is bounded by the inner edge and the outer edge of a power-transmission antenna, and perform wireless supply of power in such a manner that the first power-transmission antenna and the second power-transmission antenna generate magnetic fields in opposite directions.
[0283]
[0284] Where the power-transmission antennas 2a and 2b are formed by winding a wire in opposite directions, the same results as described above are obtained by forming magnetic fields in opposite directions by setting the phases of AC powers applied to them identical.
[0285] As described above, when the axis of the cylindrical power-reception coil 20 is inclined with respect to a plane that is perpendicular to the axes of the power-transmission antennas 2a and 2b, it is appropriate to deviate the first power-transmission antenna and the second power-transmission antenna from each other so that their central holes overlap with each other and the directions of magnetic fields generated by them are thereby inclined in the same direction as the axis of the cylindrical power-reception coil 20, and perform wireless supply of power in such a manner that the first power-transmission antenna and the second power-transmission antenna generate magnetic fields in opposite directions.
[0286]
[0287] Where the power-transmission antennas 2a and 2b are formed by winding a wire in opposite directions, the same results as described above are obtained by forming magnetic fields in the same direction by deviating the phases of AC powers applied to them by a half cycle.
EXAMPLES
[0288] In Examples, the relationship between the power reception efficiency and the makeups of the power-reception coil and the magnetic body will be described in detail on the basis of evaluation data.
Example 1
[0289] In the capsule endoscope 100c shown in
Example 2
[0290] The makeups were the same as in Example 1 except that the coil length I of the power-reception coil 20c was set at 4 mm.
Example 3
[0291] The makeups were the same as in Example 1 except that the coil length I of the power-reception coil 20c was set at 6.5 mm.
Example 4
[0292] The makeups were the same as in Example 1 except that the thickness d.sub.2 of the magnetic body 30c was set at 0.15 mm.
Example 5
[0293] The makeups were the same as in Example 1 except that the thickness d.sub.2 of the magnetic body 30c was set at 0.3 mm.
Example 6
[0294] The makeups were the same as in Example 1 except that the relative permeability of the magnetic body 30c was set at 30.
Example 7
[0295] The makeups were the same as in Example 1 except that the relative permeability of the magnetic body 30c was set at 100.
Example 8
[0296] The makeups were the same as in Example 1 except that the relative permeability of the magnetic body 30c was set at 200.
Example 9
[0297] The makeups were the same as in Example 1 except that the relative permeability of the magnetic body 30c was set at 1,000.
Example 10
[0298] The capsule endoscope 100a shown in
Comparative Example 1
[0299] In the capsule endoscope 100c shown in
[Test 1]
[0300] In Test 1, an inductance, a resistance, an impedance, and a Q value of each of Examples 1-3 and Example 10 were measured using an LCR meter at a frequency 200 kHz.
[0301] As seen from Table 1, it can be said that Example 10 (internal coil type) is approximately equivalent to Example 1 (external coil type; coil length: 4 mm) in coil performance. In Examples of the external coil type, the Q value increased and the coil performance was thus improved as the coil length I became longer.
TABLE-US-00001 TABLE 1 Coil length I (mm) External type Internal type 4 5 6.5 Inductance L (mH) 0.0413 0.0426 0.0673 0.0895 Resistance R (Ω) 1.659 1.737 2.285 2.545 Impedance Z (Ω) 51.88 53.578 84.64 112.47 Q value 31.26 30.85 37.07 44.24
[Test 2]
[0302] In Test 2, the magnitudes of induced electromotive forces of Examples 1, 4, and 5 (external coil type) and Comparative Example 1 having no magnetic body 30c were compared using ratios of voltages to a result (regarded as “1”) of Comparative Example 1. As seen from
[Test 3]
[0303] In Test 3, the magnitudes of induced electromotive forces of Examples 1 and 6-9 (external coil type) and Comparative Example 1 having no magnetic body 30c were compared using ratios of voltages to a result (regarded as “1”) of Comparative Example 1. As seen from
DESCRIPTION OF SYMBOLS
[0304] 1: Examination stage [0305] 1a: Subject placement surface of examination stage [0306] 2, 2a, 2b: Power-transmission antenna [0307] 3a, 3b: Manipulator [0308] 4: AC power source [0309] 5: Control unit [0310] 6: Transmission/reception antenna [0311] 7: Manipulation unit [0312] 8: Display unit [0313] 9: X-ray marker position detector [0314] 11a, 11b, 11c, 11d: Capsule [0315] 12: Tip cover [0316] 13a, 13b, 13c, 13d: Capsule barrel [0317] 13c1: Ring-shaped recess formed along outer circumference of capsule barrel [0318] 13d1: Ring-shaped recess formed along outer circumference of hemispherical portion of capsule barrel [0319] 14: Camera [0320] 15: Illumination device [0321] 16: Semiconductor device [0322] 17, 18a, 18b: Electronic circuit board [0323] 19: Partition wall [0324] 20, 20a, 20b, 20c, 20d: Power-reception coil [0325] 21: Coated wire [0326] 22c1, 22c2, 22d1, 22d2: Through-hole formed through capsule barrel [0327] 23c, 23d: Coating layer covering power-reception coil [0328] 24: Cap [0329] 25: Resonance capacitor [0330] 30a, 30b, 30c, 30d: Magnetic body [0331] 40a, 40b: Liquid chemical supply device [0332] 41a, 41c: Liquid chemical tank [0333] 42: Liquid chemical suction pipe [0334] 43: Electromotive valve or pump [0335] 44: Liquid chemical emission opening [0336] 50: Self-propulsion drive device [0337] 60: Microhand device [0338] 61: Shape-memorized spring [0339] 62: Ceramic heater [0340] 63: Scissors [0341] 64: Spring [0342] 70: X-ray marker [0343] 80: Capacitor [0344] 90: Vibrator [0345] 100, 100a, 100b, 100c, 100d: Capsule endoscope [0346] 200, 200a, 200b: Capsule endoscope examination instrument [0347] P: Subject [0348] Q: Tubular organ [0349] R: Sample