Pharmaceutical Use of Potassium Hydroxide

Abstract

This relates to the pharmaceutical use of KOH, in forms of topical, oral drugs or intravenous drip, prepared for treating high blood uric acid, especially gout. The external application refers to footbath in soaking solution or embrocation on attack position. The action of the drugs is also to promote the excretion of uric acid. Compared with colchicine and other drugs, KOH has three notable features. First, it takes effect quickly. No matter being applied by footbath, oral or embrocation, it can relieve symptoms within ten minutes, and the pain during gout attack will be significantly reduced. Second, it takes curative effect quickly. After application of the drugs for 2-3 consecutive days, gout symptoms will completely disappear. Third, it has no side effects. In one respect, with a low concentration, the KOH will not corrode the skin. In a further respect, potassium ion itself is diuretic and it has no harm to kidney.

Claims

1. It is a pharmaceutical use of KOH and characterized by: the application of KOH in preparation of the drugs for treating high blood uric acid, especially gout.

2. Based on the pharmaceutical use aforesaid in the claims (1), it is characterized by: the application of the aforesaid drugs prepared for treating high blood uric acid, especially gout.

3. Based on the pharmaceutical use aforesaid in the claims (2), it is characterized by: the aforesaid soaking KOH solution for external application at a concentration of 0.01-0.05mol/L.

4. Based on the pharmaceutical use aforesaid in the claims (2), it is characterized by: the aforesaid emboracation for external application at a concentration of 0.1-0.5mol/L.

5. Based on the pharmaceutical use aforesaid in the claims 1), it is characterized by: the application of oral drug of KOH prepared for treating high blood uric acid, especially gout, at a concentration of 0.001-0.005 mol/L.

6. Based on the pharmaceutical use aforesaid in the claims (1), it is characterized by: the application of KOH injection prepared for treating high blood uric acid, especially gout, at a concentration of 1-10 μmol/L.

Description

IV. EMBODIMENT

(i) Preparation of Topical Drugs

[0016] 1. Preparation of Soaking Solution [0017] Take KOH 0.56 kg, dissolve in 1 liters of distilled water, and get a concentration of 0.01 mol/L. [0018] 2. Preparation of Embrocation [0019] Take KOH16.8 g, dissolve in 1 liters of distilled water, and get a concentration of 0.3 mol/L. [0020] 2. Preparation of Oral Liquid [0021] Take KOH0.12 g, dissolve in 1 liters of distilled water, and get a concentration of 0.0021 mol/L. Take orally for 50 ml per time and one time per day.
The aforesaid KOH is a solid body. Add in chemical pure reagent when used externally, and add analytical reagent when used orally.

(ii) Experiments in Lowering Blood Uric Acid and Curing Gout

[0022] The applicant tried the drugs in person

[0023] In May 2008 when the applicant had gout attack at the position of the first metatarsophalangeal joint, his foot could not touch the ground. He dripped a cotton swab into the embrocation (0.1 mol/L) prepared by himself and embrocated on the attack position. In about ten minutes, the pain was relived and his foot could be able to touch the ground. He kept embrocating for 2-3 times per day, and gout symptoms disappeared three days later and everything got back normal.

[0024] Since then, the applicant had gout attack once a year and even twice or three times when being severe. The time is uncertain, but the position is always on foot. It is the forerunner of gout that the foot got swollen with soreness. From 2009, once he noticed the forerunner of gout, he immediately embrocated KOH solution, and the swelling and soreness disappeared quickly, which effective prevented the onset of gout. During a period of five years till 2013, the molar concentration of KOH solution of 0.1, 0.2, 0.3 and 0.4 was used respectively, and all were effective. The higher molar concentration was, the more obvious effect was.

[0025] KOH embrocation can relieve gout symptoms and cure gout through promoting uric acid excretion and lowering blood uric acid. However, this is qualitative. In order to get the quantitative data of lowering blood uric acid, he began to take footbath with KOH soaking solution, and then went to the doctor to test blood uric acid immediately. [0026] 2. Footbath in KOH Soaking Solution

[0027] The blood uric acid tested on Dec. 2, 2014 was 455 μmol/L. In order to take the test, he was requested to eat two chicken livers that day. The next day the tested blood uric acid is 495 μmol/L, and the urine uric acid tested was 6.3mmol/L, which showed that exogenous purine supplementation could increase the level of blood uric acid. On December 3, he took a footbath in 45° C. soaking solution (0.01mol/L) for an hour, and then went to test at Chaohu Hospital of Anhui Medical University. The tested blood uric acid was 486 μmol/LL, and the urine uric acid tested was 6.59 mmol/L. The blood uric acid was lowered and the urine uric acid was increased, which showed that the footbath had effectively promoted the excretion of uric acid. He kept taking footbath for once a day, on December 10, the tested blood uric acid was 389 μmol/L, dropping by 21%, and had dropped to the range of normal value, 208-428 μmol/L. [0028] 3. Test with Oral Liquid

[0029] After many years of practice in external application, the applicant realized that KOH alkaline strong though, it would have no harm to human body as long as its concentration is appropriately controlled, with no harm to skin and no harm to digestive tract. Besides, the absorption through digestive tract must be faster than percutaneous absorption, and is very convenient. So he began to take oral use tests from January 2016. To April 2016, the applicant had taken KOH solution for 23 times in order to get the ideal concentration. The oral concentration (mol/L) he had tried includes 0.001, 0.0018, 0.0021, 0.0025, 0.003, 0.005 and 0.008 in turn. At last, the concentration of oral liquid was determined to be 0.001 mol/L-0.005 mol/L. With such concentration, the oral liquid tasted same as boiled water, and brought no discomfort to the body.

[0030] Tested at Philip Ts, Chaohu City, Anhui Medical Devices Co., Ltd. on a day in April 2016, blood uric acid was 351 μmol/L, which was lowest value so far.

Test of 8 Gout Sufferers

[0031] Tested blood uric acid on Apr. 18, 2015, and took footbath in 45° C. soaking solution (0.01 mol/L) for an hour that day, and once a day later and lasted for three days. Tested blood uric acid on April 21 again. The data was summarized as follow:

TABLE-US-00001 BUA bf Bath BUA af Bath Drop Name Gender Age μmol/L μmol/L by % Yu Wenjun M 58 796 566 −28.8%  Fang Yuanping M 63 620 566 −8.7% Xiang Songbai M 74 499 474 −5.0% Ye Mingru M 66 459 423 −7.8% Hu Chunrong M 47 476 500 .sup. +5% Xu Wenming F 53 376 509  +35% Jiang Ping M 68 451 512 +13.5%  Zhang Xianfu M 67 706 618 −12.5% 

[0032] The patient Xu Wenmei was tested at Anhui Chaohu Orthopedic Hospital before the bath and at Anhui Chaohu Ethnics Hospital (Dongfeng Community Health Service Station) after the bath.

[0033] The patient Jiang Ping was tested at The Eighth People's Hospital of Hefei before and after the bath.

[0034] The patient Zhang Xianfu was tested at Chaohu Hospital of Anhui Medical University before and after the bath.

[0035] The other five patients were tested at Anhui Chaohu Orthopedic Hospital before and after the bath.

[0036] The blood uric acid of the three patients Hu Chunrong, Xu Wenmei and Jiangping wsa increased because they were going through gout attack during that period. The blood uric acid was crystallized and separated out. The crystals dissolved after the bath, which caused the increase of blood uric acid.