Correction in slit-scanning phase contrast imaging
09839407 · 2017-12-12
Assignee
Inventors
Cpc classification
G21K1/10
PHYSICS
G01N23/20075
PHYSICS
A61B6/5258
HUMAN NECESSITIES
G21K1/06
PHYSICS
International classification
A61B6/00
HUMAN NECESSITIES
G01N23/20
PHYSICS
G21K1/06
PHYSICS
Abstract
The present invention relates to calibration in X-ray phase contrast imaging. In order to remove the disturbance due to individual gain factors, a calibration filter grating (10) for a slit-scanning X-ray phase contrast imaging arrangement is provided that comprises a first plurality of filter segments (11) comprising a filter material (12) and a second plurality of opening segments (13). The filter segments and the opening segments are arranged alternating as a filter pattern (15). The filter material is made from a material with structural elements (14) comprising structural parameters in the micrometer region. The filter grating is movably arranged between an X-ray source grating (54) and an analyzer grating (60) of an interferometer unit in a slit-scanning system of a phase contrast imaging arrangement. The slit-scanning system is provided with a pre-collimator (55) comprising a plurality of bars (57) and slits (59). The filter pattern is aligned with the pre-collimator pattern (61).
Claims
1. A calibration filter grating for transforming coherent X-ray into incoherent X-ray in a slit-scanning X-ray phase contrast imaging arrangement, comprising: a first plurality of filter segments comprising a filter material; and a second plurality of opening segments; wherein the filter segments and the opening segments are arranged alternating as a filter pattern; wherein the filter material is made from a material with structural elements comprising structural parameters in the micrometer region; and wherein the filter grating is configured to be movably arranged between an X-ray source grating and an analyzer grating of an interferometer unit in a slit-scanning system of a phase contrast imaging arrangement; and wherein the filter pattern is configured to be aligned with a slit pattern of the slit-scanning system.
2. Calibration filter grating according to claim 1, wherein the structural elements are provided in a maximum range of 10 μm.
3. Calibration filter grating according to claim 1, wherein the filter material is provided as at least one of the group of: fluid bubbles comprising gaseous bubbles and liquid bubbles; and fiber-based material; and wherein the filter material is made from low atomic number elements.
4. Calibration filter grating according to claim 1, wherein the filter is a de-coherence filter providing small angle scattering for coherent X-ray radiation provided by an X-source with a source grating for phase contrast imaging.
5. A slit-scanning X-ray phase contrast imaging arrangement, comprising: an X-ray source; a source grating; a pre-collimator; an interferometer unit comprising a phase grating and an analyzer grating; an X-ray detector with a plurality of detector segments displaced from each other; and a calibration device; wherein the source grating provides at least partially coherent X-ray radiation; wherein the pre-collimator comprises a plurality of bars and slits to provide an X-ray beam width with a plurality of X-ray beam sections displaced from each other by radiation-free sections; wherein the calibration device is a calibration filter grating according to one of the preceding claims; and wherein the calibration filter grating is arranged between the source grating and the analyzer grating; and wherein the calibration filter grating is movable between: I) a first, calibrating position, in which the filter segments are arranged in the X-ray beam parts forming the plurality of X-ray beam sections; and II) a second, scanning position, in which the filter segments are arranged out of the X-ray beam parts forming the plurality of X-ray beam sections that are detected by the detector segments.
6. Slit-scanning X-ray phase contrast imaging arrangement according to claim 5, wherein, the calibration filter grating is arranged: i) between the source grating and the pre-collimator; or ii) between the pre-collimator and the phase grating; or iii) between the phase grating and the analyzer grating.
7. Slit-scanning X-ray phase contrast imaging arrangement according to claim 5, wherein in the scanning position, the calibration filter grating remains between the source grating and the analyzer grating; and wherein the filter segments are arranged in the radiation-free sections of the X-ray beam or in the X-ray beam parts that are blocked by bars of the pre-collimator.
8. Slit-scanning X-ray phase contrast imaging arrangement according to claim 5, wherein the phase grating is provided with a first period; and wherein the structures of the structural elements are provided in a range of approximately the first period.
9. Slit-scanning X-ray phase contrast imaging arrangement according to claim 5, wherein a displacement device for moving the calibration filter grating between the first, calibrating position and the second, scanning position is provided.
10. Slit-scanning X-ray phase contrast imaging arrangement according to claim 9, wherein the displacement device is provided as at least one of the group of: a motor driven translation stage; a electromagnetic actuation stage; and a piezoelectric translation stage.
11. An X-ray imaging system, comprising: an X-ray image acquisition arrangement; a processing device; and an object supporting device; wherein the X-ray image acquisition arrangement is provided as a slit-scanning X-ray phase contrast imaging arrangement according to claim 5; wherein the object supporting device is configured to support an object to be examined; wherein the X-ray image acquisition arrangement is configured to detect an X-ray image signal as reference signal for calibration purposes, wherein an object is arranged outside the X-ray radiation; and wherein the processing unit is configured to determine a calibration factor based on the reference signal, wherein the calibration factor represents a gain induced signal structure; and to provide the calibration factor for calibrated X-ray imaging procedures.
12. X-ray imaging system according to claim 11, wherein the filter segments of the calibration device are configured to be arranged in the X-ray beam parts forming the X-ray beam sections for calibration purposes and outside the X-ray beams parts forming the X-ray beam sections for object and phase reference acquisition steps.
13. A computer program element for controlling an apparatus claim 1, which, when being executed by a processing unit, is adapted to perform the method for calibration in slit-scanning X-ray phase contrast imaging, comprising the following steps: a) arranging a first plurality of filter segments of a calibration filter grating, for transforming coherent X-ray into incoherent X-ray, in X-ray beam parts forming X-ray beam sections of an X-ray image acquisition arrangement at a location between a source grating and an analyzer grating; the filter segments comprise a filter material made from a material with structural elements comprising structural parameters in the micrometer region; b) providing X-ray radiation; c) detecting an X-ray image signal as reference signal for calibration purposes; d) determining a calibration factor based on the reference signal, wherein the calibration factor represents a gain induced signal structure; and e) providing the calibration factor for calibrated X-ray imaging procedures.
14. A computer readable medium having stored the program element of claim 13.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) Exemplary embodiments of the invention will be described in the following with reference to the following drawings:
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DETAILED DESCRIPTION OF EMBODIMENTS
(12)
(13) The filter material 12, i.e. the filter segments 11 are shown as a grid-like arrangement 16 of the filter material in
(14) The filter material 12 may also be arranged in a grid-like support construction (not further shown), such as in housing parts or frame parts. The structural elements 14 are provided in a maximum range of 10 μm.
(15) As a material with the structural parameters in the micrometer region, materials with strong de-coherent properties are provided, such as: a) air or gas bubbles-based material, such as industrial foams, for example Styrofoam® and Rohacell® or polyurethane-based foams; b) liquid-‘bubble’- or powder-based material, such as oil/water-emulsions or liquid-based polishing agents. In a further example, flour- or dust-based materials are provided as standalone material or embedded in a rigid matrix; c) fiber-based material, such as food, paper, tissue/fabrics and mineral wool, etc, which can be provided either with random orientation of fibers up to highly-oriented ones; and/or d) special kinds of rubber materials, such as some eraser materials or cork.
(16) When choosing a filter material containing only low atomic number elements, the X-ray attenuation will be very low, even in X-ray mammography imaging for example. The restriction provided is that a homogenous and flat filter can be inserted into the X-ray path. For example, a rigid flat filter is provided, or an emulsion or liquid in a provided container. The temporarily insert of the de-coherence filter into the X-ray beam may be provided by hand or motor-driven, or computer-controlled by a translation stage.
(17) In an example, the filter material 12 is provided as fiber-based material, wherein the filter material 12 is made from low atomic number elements. For example, the filter material 12 is made from a material with a maximum value of approximately C.sub.max≈20.
(18) In a further example, the filter material 12 is provided as an industrial foam, such as Styrofoam®, Rohacell®, Zotek®, Kynar® or others (not further shown).
(19) In a still further example, a lightweight material, such as wood or paper, or a tissue or fabric, is provided with internal microstructures (not further shown).
(20) According to an example, the filter material 12 is provided with a thickness 24 in the range of approximately 5 to 100 mm.
(21) According to a further example, also shown in
(22)
(23) The X-ray source 52 generates incoherent X-ray radiation 68. The X-ray radiation passes the source grating 54 and thus becomes at least partially coherent X-ray radiation 70. The coherent X-ray radiation 70 then passes the pre-collimator 55 to provide the plurality of X-ray beam sections and then travels along a region 72 that is provided to receive an object 74 towards the phase grating 58 and the analyzer grating 60, and finally hits the detector 62.
(24) The object 74 may be provided with structures 76 which will be projected by the coherent X-ray radiation 70 on the detector 62, which is indicated with the similar structure 78. However, it must be noted that the detected structure 78 is provided after evaluating the detector signals.
(25) For calibration purposes, the object 74 is removed from the region 72, and will be arranged in the region 72 after the calibration scan, as indicated with a second arrow 80.
(26) The phase grating 58 is provided with a first period 82 and the structures of the structural elements 14 are provided in a range of approximately the first period. The structures are provided in a range of about 30 to 300 percent of the value of the first period 82.
(27) In
(28) The calibration filter grating 10 is movable between a first, calibrating position P.sub.CAL, in which the filter segments are arranged in the X-ray beam parts forming the plurality of X-ray beam sections 32, and a second, scanning position (P.sub.IM), in which the filter segments are arranged out of the X-ray beam parts forming the plurality of X-ray beam sections 32 that are detected by the detector segments 63. The movement between the two positions is indicated with a double-arrow 65.
(29) In
(30) In
(31) The examples of
(32) In
(33) In
(34) In
(35) The examples of
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(37) Further, a distance 92 is indicated between the source grating 54, which source grating is also referred to as G0, and the phase grating 58, also referred to as G1. This distance 92 is also referred as distance L. A further distance 94 is indicated between the phase grating 58 and the analyzer grating 60, which further distance 94 is also referred to as distance D. Still further, a line 96 indicates a width W of the detector 62.
(38) Still further, a movement±ΔL of the source grating 54 is indicated with arrows 98.
(39) In case of scanning differential phase contrast imaging in the shown setup with the de-coherence filter 10 inserted into the X-ray pathway, the detector detects a signal that is graphically represented on the right side of the detector 62. A graph 100 indicates gain induced disturbances of detector flux. As can be seen, the Moiré fringe pattern is not visible, i.e. the Moiré fringe pattern is removed, and only signal fluctuations proportional to the individual pixel gain shows up at the detector 62. It must be noted that the graph 100 in reality is a discontinued graph with curve segments and missing segments, since the X-ray radiation from the X-ray source passes the pre-collimator 55 only in segments, i.e. in portions or pieces of X-ray radiation. Thus, only in these portions or segments radiation occurs that is filtered by the de-coherence filter and that will be detected. The discontinued graph 100 is shown in a continuous manner in
(40) After the calibration steps, the calibration filter grating 10 is moved such that the filter segments 11 are arranged out of the X-ray beam parts forming the plurality of X-ray beam sections that are detected by the detector segments, and the object 84 can be arranged between the X-ray source, the X-ray source grating respectively, and the interferometer unit 56 for imaging purposes. For example, the sample can be moved laterally or rotationally, as indicated with arrows 102.
(41) In an example, the application of the special de-coherence filter, i.e. the filter grating, is performed after scanning the object. In a further example, the application of the special de-coherence filter is performed also after the phase reference scan. In other words, the calibration scan is performed afterwards.
(42) In a further example, the calibration filter grating 10 is arranged with a calibration distance D.sub.cal of approximately 5 to 10 mm from the phase grating 58. This example is shown in addition in
(43) In a further example, not further shown in detail, the calibration filter grating 10 is arranged approximately half distance between the source grating G0 and the phase grating G1. In a further example, the calibration filter grating 10 is then provided with an increased filter thickness to at least partly compensate for the reduced filter strength.
(44) The detected signal, as indicated with the graph 100, can then be used for determining a calibration factor representing the gain induced signal structure. This calibration factor can then be provided for calibration for further X-ray imaging procedures.
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(47) As can be seen from
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(49) A dotted frame 220 indicates the calibration device 64, i.e. the calibration filter grating 10, that can temporarily be arranged in the X-ray radiation for detecting the calibration signal in order to determine a calibration factor.
(50) It must be noted that
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(52) The arrangement step 302 is also referred to as step a), the first provision step 304 as step b), the detection step 306 as step c), the determination step 308 as step d), and the second provision step 310 as step e).
(53) In an example, in step e), the calibration factor is used to remove gain induced disturbances in next image acquisition steps.
(54) According to a further example, the steps a) to d) are repeated before an object is arranged for a new image acquisition procedure. This further example is also shown in combination with
(55) In another exemplary embodiment of the present invention, a computer program or a computer program element is provided that is characterized by being adapted to execute the method steps of the method according to one of the preceding embodiments, on an appropriate system.
(56) The computer program element might therefore be stored on a computer unit, which might also be part of an embodiment of the present invention. This computing unit may be adapted to perform or induce a performing of the steps of the method described above. Moreover, it may be adapted to operate the components of the above described apparatus. The computing unit can be adapted to operate automatically and/or to execute the orders of a user. A computer program may be loaded into a working memory of a data processor. The data processor may thus be equipped to carry out the method of the invention.
(57) This exemplary embodiment of the invention covers both, a computer program that right from the beginning uses the invention and a computer program that by means of an up-date turns an existing program into a program that uses the invention.
(58) Further on, the computer program element might be able to provide all necessary steps to fulfill the procedure of an exemplary embodiment of the method as described above.
(59) According to a further exemplary embodiment of the present invention, a computer readable medium, such as a CD-ROM, is presented wherein the computer readable medium has a computer program element stored on it which computer program element is described by the preceding section.
(60) A computer program may be stored and/or distributed on a suitable medium, such as an optical storage medium or a solid state medium supplied together with or as part of other hardware, but may also be distributed in other forms, such as via the internet or other wired or wireless telecommunication systems.
(61) However, the computer program may also be presented over a network like the World Wide Web and can be downloaded into the working memory of a data processor from such a network. According to a further exemplary embodiment of the present invention, a medium for making a computer program element available for downloading is provided, which computer program element is arranged to perform a method according to one of the previously described embodiments of the invention.
(62) It has to be noted that embodiments of the invention are described with reference to different subject matters. In particular, some embodiments are described with reference to method type claims whereas other embodiments are described with reference to the device type claims. However, a person skilled in the art will gather from the above and the following description that, unless otherwise notified, in addition to any combination of features belonging to one type of subject matter also any combination between features relating to different subject matters is considered to be disclosed with this application.
(63) However, all features can be combined providing synergetic effects that are more than the simple summation of the features.
(64) While the invention has been illustrated and described in detail in the drawings and foregoing description, such illustration and description are to be considered illustrative or exemplary and not restrictive. The invention is not limited to the disclosed embodiments. Other variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing a claimed invention, from a study of the drawings, the disclosure, and the dependent claims.
(65) In the claims, the word “comprising” does not exclude other elements or steps, and the indefinite article “a” or “an” does not exclude a plurality. A single processor or other unit may fulfill the functions of several items re-cited in the claims. The mere fact that certain measures are re-cited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage. Any reference signs in the claims should not be construed as limiting the scope.