NEGATIVE-PRESSURE PARACENTESIS SYRINGE AND USE THEREOF

Abstract

The present invention discloses a disposable negative-pressure anterior chamber Paracentesis syringe which belongs to the technical field of medical supplies. It comprises nine parts, including a needle cap, a Paracentesis syringe, a needle base, an internal needle, a protective cover of the internal needle, an airlock, a needle tube, a collection tube and a collection tube rack. The invention has the advantages that it fixes the Paracentesis syringe during puncture and limits the depth of the needle insertion, releases the aqueous humor slowly to prevent a sudden drop of the intraocular pressure, reduces the risk of the intraocular infection by separating the anterior chamber from outside and the collection tube can collect and store the aqueous humor directly.

Claims

1-15. (canceled)

16. A paracentesis syringe, comprising: a syringe barrel; a needle base at least partially fitted within the syringe barrel and having a front end and a back end; a needle having a paracentesis end and an internal portion, wherein the needle base is configured to hold the needle; and a collection tube having a front end and a body for collecting aqueous humor, wherein the collection tube is configured to move inside the syringe barrel towards the needle such that the internal portion of the needle penetrates through the front end of the collection tube into the body for collecting aqueous humor.

17. The paracentesis syringe of claim 16, wherein the paracentesis end of the needle is configured to penetrate a corneal limbus.

18. The paracentesis syringe of claim 16, wherein the needle penetrates through and is fixed in the needle base.

19. The paracentesis syringe of claim 16, further comprising an elastic material configured to cover the internal portion of the needle.

20. The paracentesis syringe of claim 19, wherein an elastic protective cover is connected to the needle base and extends to cover the internal portion of the needle.

21. The paracentesis syringe of claim 20, wherein the back end of the needle base is provided with a cylinder configured to fix the elastic protective cover thereon.

22. The paracentesis syringe of claim 16, wherein the front end of the needle base has a cambered surface configured to fit on a corneal limbus, a curve of the cambered surface being substantially equal to a curve of the corneal limbus.

23. The paracentesis syringe of claim 16, wherein the collection tube is operated by a negative pressure.

24. The paracentesis syringe of claim 16, wherein the front end of the collection tube comprises: an opening, and an airlock situated at the opening and configured to engage the syringe barrel.

25. The paracentesis syringe of claim 24, wherein the airlock has a front end and a back section, wherein the front end of the airlock has a first concave configured for receiving the internal portion of the needle to penetrate therethrough.

26. The paracentesis syringe of claim 25, wherein the back section of the airlock has a second concave configured for the internal portion of the needle to penetrate therethrough.

27. The paracentesis syringe of claim 16, wherein the collection tube is a 0.5 mL collection tube.

28. The paracentesis syringe of claim 16, wherein the collection tube is configured to be separated from the syringe barrel.

29. The paracentesis syringe of claim 16, further comprising a collection tube rack connected to the collection tube and configured to move the collection tube.

30. A method for collecting aqueous humor from a subject using the paracentesis syringe of claim 16, comprising: puncturing a cornea into an anterior chamber of the subject with the paracentesis end of the needle; moving the collection tube towards the needle, such that the internal portion of the needle penetrates through the front end of the collection tube into the body for collecting aqueous humor; allowing aqueous humor from the anterior chamber to pass through the needle and flow into the collection tube under a pressure difference between an intraocular pressure and a negative pressure of the collection tube; and pulling the paracentesis syringe out from the anterior chamber.

31. The method of claim 30, further comprising removing the collection tube containing aqueous humor collected therein from the syringe barrel.

32. The method of claim 31, further comprising testing the collected aqueous humor for diagnosis of uveitis or masquerade syndrome in the subject.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0038] The following is a further description to the present invention in combination with the figures and embodiments.

[0039] FIG. 1 is a schematic view of the structure of the disposable negative-pressure anterior chamber Paracentesis syringe;

[0040] FIG. 2 is a schematic view of the relationship between the airlock left view and the needle tube;

[0041] FIG. 3 is a schematic view of puncturing the anterior chamber with the disposable negative-pressure anterior chamber Paracentesis syringe;

[0042] FIG. 4 is a schematic view of collecting the aqueous humor with the disposable negative-pressure anterior chamber Paracentesis syringe;

[0043] FIG. 5 is a schematic view of pulling out the disposable negative-pressure anterior chamber Paracentesis syringe;

[0044] FIG. 6 is a schematic view of separating the needle tube from the collection tube;

[0045] FIG. 7 is a schematic view of separating the collection tube from the collection tube rack.

DETAILED DESCRIPTION

[0046] As shown in FIG. 1, a disposable negative-pressure anterior chamber Paracentesis syringe comprises nine parts: a needle cap (1), a Paracentesis syringe (2), a needle base (3), an internal needle (4), a protective cover of the internal needle (5), an airlock (6), a needle tube (7), a collection tube and (8), a collection tube rack (9). The Paracentesis syringe (2) and the internal needle (4) are connected integrally whose texture and inner and outer diameter are the same with that of a 1 ml syringe. The needle base (3) is made of a hard material and connected with the needle tube (7) closely, the Paracentesis syringe (2) and the internal needle (4) penetrate and are fixed on the middle of the needle base (3); the front end is a cambered surface which has a curve equal to that of a corneal limbus, the cambered surface can be fixed on the corneal limbos during operation to increase the stability of the Paracentesis syringe (2) in the anterior chamber; the back end is a cylinder which is used to fix the protective cover of the internal needle (5). The protective cover of the internal needle (5) is made up of a soft elastic material, and is a tubular component with a closed back end and a front end opening, the inner diameter of which is less than the cylindrical diameter of the back end of needle base (4); The airlock (6) is made up of a soft material which can be penetrated by the internal needle easily, the airlock (6) has a petal-shaped front section to be loosely and elastically fixed with the needle tube (7) and not to form an airtight cavity in the front end of the airlock (6) and the back end of the needle base (3), the back section of the airlock is expandable to seal the opening of the collection tube (8) so that an airtight cavity is formed inside the collection tube (8); the size of the collection tube (8) is the same with that of a 0.5 ml Eppendorf tube, therefore, the commercially available centrifuge can be used to centrifuge directly. The collection tube (8) is spirally connected with the front end of the collection tube rack. (9) which is easy to disassemble.

[0047] The following is the full description of the operational process of the anterior chamber puncture and the aqueous humor collection:

[0048] As shown in FIG. 3, a user holds the disposable negative-pressure anterior chamber Paracentesis syringe with the thumb and middle finger to puncture from the periphery of the cornea (10) into the anterior chamber (11), it is noted that the cambered surface of the front end of the needle base should fit to the conical limbus;

[0049] As shown in FIG. 4, the user taps the rear end of the collection tube rack (9) with the index finger, the collection tube (8) moves forward in the needle tube (7), the internal needle (4) punctures the airlock (6) and then penetrates into the collection tube (8), then the protective cover of the internal needle (5) rolls up, and the aqueous humor passes the anterior chamber (11) through the Paracentesis syringe (2) and the protective cover of the internal needle (5) into the collection tube (8) due to the pressure difference between the intraocular pressure and the negative pressure of the collection tube (8); the pressure of the collection tube (8) increases as the aqueous humor inside the collection tube increases gradually, the outflow speed of the aqueous humor declines and stops eventually.

[0050] As shown in FIG. 5, a user pulls the Paracentesis syringe (2) out from the anterior chamber (11).

[0051] As shown in FIG. 6, a user removes the needle tube (7) from the collection tube (8).

[0052] As shown in FIG. 7, a user removes the collection tube (8) from the collection tube rack (9). The aqueous humor in the collection tube (8) can be used for inspection and cryopreservation directly.

[0053] Finally, it should be noted that: obviously, the above-mentioned embodiments are examples only for clear explanation of the present application and cannot be taken as a limitation to the embodiments. For an ordinary person skilled in the art, there are some other different forms of changes or alterations can be made based on the description mentioned above. There is no need and no way to list all the embodiments here. Those changes or alterations obviously derived from them still belong to the protection scope of the invention.