NANOPARTICLE PROVISION MEDIUM FOR THERMOTHERAPY AND THERMOTHERAPY SYSTEM USING SAME

Abstract

The technology disclosed in the present specification relates to a nanoparticle providing medium for hyperthemia, and the nanoparticle providing medium for hyperthemia according to an embodiment may be formed so as to capture nanoparticles in a region or one or more divided regions and block contact between the nanoparticles and a body.

Claims

1. A nanoparticle providing medium for hyperthemia, comprising nanoparticles and one or more divided regions, wherein the nanoparticles are captured in the one or more divided regions and blocked from contact with the human body.

2. The nanoparticle providing medium for hyperthemia according to claim 1, further comprising a cap coupled to one end of the nanoparticle providing medium.

3. The nanoparticle providing medium for hyperthemia according to claim 1, wherein the nanoparticles are made of one or more materials capable of self-heating.

4. The nanoparticle providing medium for hyperthemia according to claim 1, wherein the nanoparticle providing medium for hyperthemia is made of one or more of polycaprolactone, poly(ethylene-vinyl acetate), polydioxanone and silicone, and the size or length of the nanoparticle providing medium may be adjusted according to be treated.

5. The nanoparticle providing medium for hyperthemia according to claim 1, further comprising a wireless communication module configured to perform wireless communication with an external control device.

6. The nanoparticle providing medium for hyperthemia according to claim 1, further comprising a sensor configured to sense temperature, pressure, oxygen saturation or pH of the surface of the nanoparticle providing medium.

7. The nanoparticle providing medium for hyperthemia according to claim 1, wherein the nanoparticle providing medium is configured in the shape of a tube or a catheter.

8. The nanoparticle providing medium for hyperthemia according to claim 1, wherein the nanoparticle providing medium is configured in the shape of a plate or a patch.

9. A hyperthemia system using a nanoparticle providing medium, comprising the nanoparticle providing medium according to claim 1 and an alternating magnetic field generating device, wherein the alternating magnetic field generating device applies a alternating magnetic field to the nanoparticle providing medium, and the nanoparticle providing medium is configured to block contact between the nanoparticles and the human body.

Description

DESCRIPTION OF DRAWINGS

[0023] In order to more fully understand the drawings cited in present specification, a brief description of each drawing is provided.

[0024] FIG. 1 shows a nanoparticle providing medium for hyperthemia configured in the shape of a tube or a catheter and nanoparticles captured in one or more divided regions therein as an embodiment of the technology disclosed in the present specification.

[0025] FIG. 2 shows that a cap is further comprised at one end of a nanoparticle providing medium configured in the shape of a tube or a catheter.

[0026] FIG. 3 shows a structure comprising a cap, a wireless communication module and a sensor in a nanoparticle providing medium configured in the shape of a tube or a catheter.

[0027] FIG. 4 shows that a nanoparticle providing medium is made in the shape of a plate or a patch as another embodiment of the technology disclosed in the present specification, and nanoparticles captured in one or more divided regions in the nanoparticle providing medium.

[0028] FIG. 5 shows that a cap is further comprised in a nanoparticle providing medium configured in the shape of a plate or a patch.

[0029] FIG. 6 shows an embodiment further comprising a cap, a wireless communication module and a sensor in a nanoparticle providing medium configured in the shape of a plate or a patch.

[0030] FIG. 7 shows the configuration of a hyperthemia system in which a nanoparticle providing medium in the shape of a catheter or a tube is inserted into the human body and an alternating magnetic field generating device applies an alternating magnetic field toward the inserted site to perform hyperthemia.

[0031] FIG. 8 shows the configuration of a hyperthemia system in which a nanoparticle providing medium in the shape of a plate or a patch is inserted into the human body and an alternating magnetic field generating device applies an alternating magnetic field toward the inserted site to perform hyperthemia.

MODE FOR CARRYING OUT THE INVENTION

[0032] Since the technology disclosed in the present specification may have various modifications and may have various embodiments, specific embodiments will be illustrated in the drawings and described in detail though the detailed description. However, this is not intended to limit the technology disclosed in the present specification to specific embodiments, it is to be understood that the technology disclosed in the present specification includes all modifications, equivalents, and substitutes included in the spirit and technical scope of the technology disclosed in the present specification.

[0033] In describing the technology disclosed in the present specification, if it is determined that the specific description of the related known technologies may unnecessarily obscure the gist of the technology disclosed in the present specification, the detailed description thereof will be omitted. In addition, numbers (for example, 1st, 2nd, and the like) used in the description process of the present specification are only identification symbols for distinguishing one component from other components.

[0034] In addition, when it mentioned that a component is “connected” or “coupled” to another component in the present specification, it is to be understood that the component may be directly connected or coupled to the other component, but may be connected or combined through another component in the middle unless otherwise specifically stated.

[0035] In addition, in the present specification, a component expressed as “... part” may mean that two or more components may be combined into one component, or one component may be divided into two or more for each more subdivided function. In addition, it goes without saying that each of the components to be described below may additionally perform some or all of the functions of other components in addition to the main functions that each component is responsible for, and some of the main functions that each component is responsible for may be exclusively performed by other component.

[0036] Expressions such as “1st”, “2nd”, “first”, or “second” used in various embodiments may modify various components regardless of order and/or importance, and do not limit the components. For example, without departing from the scope of the technology disclosed in the present specification, a first component may be referred to as a second component, and similarly, a second component may also be renamed to a first component.

[0037] Hereinafter, a nanoparticle providing medium for hyperthemia according to a preferred embodiment and a system using the same will be described in detail.

[0038] Referring to FIG. 1, the nanoparticle providing medium 10 for hyperthemia according to an embodiment of the present invention may be configured in the shape of a tube or a catheter, and the nanoparticles may be respectively captured at positions divided into a plurality of partitioned regions 110 in the nanoparticle providing medium 10. This nanoparticle providing medium 10 may be made of a material harmless to the human body, such as polycaprolactone (PCL), poly(ethylenevinyl acetate) (PEVA), polydioxanone (PDO) and silicone (SE-1700), and may be composed of other different materials. In addition, its size or length may be appropriately adjusted to suit the site to be treated.

[0039] The nanoparticle providing medium 10 may be used for hyperthemia, and prevents various unpredictable side effects caused by the nanoparticles by completely blocking contact with each other so that the nanoparticles are not absorbed into the human body. Specifically, since the nanoparticles have a dark color, when injected into the human body as it is, the corresponding site cannot be prevented from being colored black, and these nanoparticles are absorbed into the human body and may cause inflammation in the process of movement or may cause other serious side effects. Therefore, the nanoparticle providing medium 10 is configured to block any contact so that the nanoparticles are not absorbed into the human body, thereby providing the effect of preventing the side effects described above in advance.

[0040] In addition, by designating one or more partitioned regions 110 inside the nanoparticle providing medium 10, the nanoparticles may be captured in each divided region 110 of the nanoparticle providing medium 10. Accordingly, the hyperthemia effect may be greatly increased by providing the heating effect through the nanoparticles to a wide site without concentrating on one region.

[0041] FIG. 2 shows an embodiment in which a cap 120 is further included in the nanoparticle providing medium 10 configured in the shape of a tube or a catheter.

[0042] According to FIG. 2, the cap 120 is coupled to one end of the nanoparticle providing medium 10, and serves to prevent the nanoparticles from leaking or flowing to the outside. The cap 120 of the nanoparticle providing medium 10 may be configured in a dome shape or an angled shape as shown in FIG. 2 but may be configured in any shape other than these, and the shape of the cap 120 is not limited to the embodiment as shown in FIG. 2.

[0043] FIG. 3 shows an embodiment in which the cap 120, the wireless communication module 130 and the sensor 140 are further provided in the nanoparticle providing medium 10 configured in the shape of a tube or a catheter.

[0044] The wireless communication module 130 may be further included in a location or a periphery of the cap 120. The wireless communication module 130 may receive data such as temperature, pressure, oxygen saturation, pH, and the like of the surface of the nanoparticle providing medium 10 measured from the sensor 140 included in the nanoparticle providing medium 10, and transmit the data towards an external control device. Such data may be appropriately utilized in the course of hyperthemia and used to control treatment duration, strength and frequency of the magnetic field.

[0045] FIG. 4 shows a nanoparticle providing medium 20 configured in the shape of a plate or a patch.

[0046] According to FIG. 4, the nanoparticle providing medium 20 is formed to completely block the contact between the nanoparticles and the human body, as shown in FIG. 1, and the material may be made of polycaprolactone (PCL), poly(ethylene-vinyl acetate) (PEVA), polydioxanone (PDO) and silicone (SE-1700), which are harmless to the human body as in the nanoparticle providing medium 10 of FIG. 1, and may be composed of other different materials. In addition, as in the nanoparticle providing medium 10 of FIG. 1, its size or length may be appropriately adjusted to suit the site to be treated.

[0047] Likewise, one or more partitioned regions 210 are provided inside the nanoparticle providing medium 20, and nanoparticles are captured in these regions 210, respectively. Thus, when an alternating magnetic field is applied to widely spaced nanoparticles, a uniform thermal effect may maintained on the site to be treated, so that the hyperthemia effect may be remarkably improved.

[0048] FIG. 5 shows an embodiment in which a cap 220 is further included in the nanoparticle providing medium 20 configured in the shape of a plate or a patch.

[0049] According to FIG. 5, the cap 220 is coupled to one end of the nanoparticle providing medium 20, and serves to prevent the nanoparticles from leaking or flowing to the outside. The cap 220 of the nanoparticle providing medium 20 may be configured in a dome shape or an angled shape as shown in FIG. 5 but may be configured in any shape other than these, and the shape of the cap 220 is not limited to the embodiment as shown in FIG. 2.

[0050] FIG. 6 shows an embodiment in which the cap 220, the wireless communication module 230 and the sensor 240 are further provided in the nanoparticle providing medium 20 configured in the shape of a plate or a patch.

[0051] The wireless communication module 230 may be further included in a location or a periphery of the cap 220. The wireless communication module 230 performs an operation of receiving data such as temperature, pressure, oxygen saturation, pH, and the like of the surface of the nanoparticle providing medium 20 measured from the sensor 240 included in the nanoparticle providing medium 20, and transmitting the data towards an external control device, as described in FIG. 3. Likewise, such data is appropriately utilized in the course of hyperthemia and used to control treatment duration, strength and frequency of the magnetic field.

[0052] Hereinafter, a hyperthemia system using a nanoparticle providing medium according to another embodiment including the above configuration will be described.

[0053] FIG. 7 shows the configuration of a hyperthemia system using a nanoparticle providing medium, further comprising an alternating magnetic field generating device 30 for applying an alternating magnetic field to the nanoparticle providing medium 10 configured in the shape of a catheter or a tube, wherein thermal treatment is performed through an alternating magnetic field applied from such alternating magnetic field generating device 30.

[0054] According to FIG. 7, the nanoparticle providing medium 10 injected by dividing the nanoparticles into the partitioned regions is inserted into the target site to be treated, and the alternating magnetic field generating device 30 appropriately applies an alternating magnetic field to such nanoparticle providing medium 10. When an alternating magnetic field is applied to the magnetic nano-medium, an excellent temperature rise phenomenon is observed for nanoparticles as described in detail in (Patent Document 1) KR 10-2017-0115951 A, referenced in the present specification. Therefore, it is possible to treat various diseases such as tumors through the thermal effect of these nanoparticles, and in addition, the nanoparticle providing medium 10 according to an embodiment disclosed in the present specification may play a role of completely blocking various side effects triggered by nanoparticles that may occur during such a treatment process.

[0055] In the hyperthemia system using the nanoparticle providing medium, the alternating magnetic field generating device 30 applies a low-frequency alternating magnetic field harmless to the human body, and the strength and frequency of the alternating magnetic field may be appropriately controlled to obtain a target temperature. When an alternating magnetic field is applied, the nanoparticles self-heat by spin rotation, and the symptoms of various diseases may be improved by hyperthermia stimulation of cancer tissue or deep brain that is more sensitive to heat.

[0056] Specifically, normal cells are killed at a temperature of about 46° C. or higher, but cancer cells may be effectively killed even at a temperature of about 42° C. or higher because they have heat-sensitive properties. Therefore, the hyperthemia system through the nanoparticle providing medium disclosed in the present specification may properly treat a tumor such as cancer by generating an appropriate thermal effect in a site requiring treatment, and has a therapeutic effect with minimal side effects.

[0057] In addition, when deep brain hyperthermia stimulation is used as shown in FIG. 7, in addition to the treatment of the tumors described above, a useful effect may also be provided for indications such as abnormal movements such as Parkinson’s disease, essential tremor (hand tremor) and dystonia, mental disorders such as dementia or Alzheimer’s disease, depression, obsessive compulsive disorder, Tourette syndrome and schizophrenia, various pains of unknown cause, disturbance of consciousness, and stress disorder after stroke (cerebral infarction, cerebral hemorrhage), similar to the effect of the existing deep brain stimulator. The existing deep brain stimulator is a method of treating abnormal sites by stimulating abnormally activated cells with high-frequency electrodes, so that there were disadvantages in that damage to surrounding cells may be caused and the risk of using high-frequency electrodes increases. Therefore, it will be said that the hyperthemia system using the nanoparticle providing medium 10 as described above provides a safer and more useful effect in the treatment of various indications described above.

[0058] FIG. 8 shows the configuration of a hyperthemia system using a nanoparticle providing medium, further comprising an alternating magnetic field generating device 30 for applying an alternating magnetic field to the nanoparticle providing medium 20 configured in the shape of a plate or a patch, wherein thermal treatment is performed through an alternating magnetic field applied from such alternating magnetic field generating device 30.

[0059] According to FIG. 8, as in the configuration of the system of FIG. 7, the nanoparticle providing medium 20 injected by dividing the nanoparticles into the partitioned regions is inserted into the target site to be treated, and the alternating magnetic field generating device 30 appropriately applies an alternating magnetic field to such nanoparticle providing medium 20. When an alternating magnetic field is applied to the magnetic nano-medium, an excellent temperature rise phenomenon is observed for nanoparticles. Therefore, it is possible to improve the symptoms of various diseases such as tumors through the thermal effect of these nanoparticles, and in addition, the nanoparticle providing medium 20 according to an embodiment disclosed in the present specification may play a role of completely blocking various side effects triggered by nanoparticles that may occur during such a treatment process.

[0060] As in the system of FIG. 7, in the hyperthemia system using the nanoparticle providing medium as shown in FIG. 8, the alternating magnetic field generating device 30 applies a low-frequency alternating magnetic field harmless to the human body, and the strength and frequency of the alternating magnetic field may be appropriately controlled to obtain a target temperature.

[0061] In addition, the hyperthemia system using the nanoparticle providing medium as shown in FIG. 8 may perform brain cortex hyperthermia stimulation, and has the same indications as in the deep brain stimulation, but may provide a treatment system with further improved versatility that may be applied to various diseases by appropriately inserting it into a site requiring stimulation according to various diseases and expanding the thermal stimulation site more widely.

[0062] In addition, although not shown through the drawings of the present specification, the configuration of the hyperthemia system may also be used in treatment methods such as spinal cord hyperthermia stimulation, cauda equina hyperthermia stimulation, and peripheral nerve hyperthermia stimulation, and this treatment methods may be used for indications such as cancerous pain in the spinal cord and deep peripheral nerves, pain after spinal surgery, spasticity after spinal surgery, spasticity due to cerebral palsy, and stress disorder after spinal cord injury. The hyperthemia system effective for such various indications is designed to provide a safer, less side-effect and more efficient treatment method compared to the existing technology.

[0063] Although the present invention has been described in detail above, the scope of a right for the present invention is not limited thereto, and it will be apparent to those of ordinary skill in the art that various modifications and changes may be made without departing from the technical spirit of the present invention described in the claims.