Sensitization composition and method of use

Abstract

The present invention relates to a topical composition and method of use, specifically an oil-in-water emulsion, comprised of sweet almond oil, lavender oil, rose oil, cinnamon bark oil, and coriander seed oil in a physiologically acceptable topical carrier. The composition is applied to a circumcised penis to enhance sensitivity, preferably twice daily for a time period of at least about two weeks. Thereafter a maintenance dose can be applied once a day to maintain a desired level of sensitivity.

Claims

1. A topical sensitization composition comprising an effective amount of an admixture of sweet almond oil, lavender oil, cinnamon bark oil, coriander seed oil and rose oil, wherein the oils are present in said admixture at a respective weight ratio of about 200:33:25:17:1; and wherein the composition is in the form of a physiologically acceptable oil-in-water emulsion.

2. The topical composition in accordance with claim 1 wherein the oil-in-water emulsion has the consistency of a topical cream.

3. A topical oil-in-water emulsion sensitization cream composition comprising, based on the weight of the composition: about 2 to about 10 weight percent sweet almond oil, about 0.01 to about 2 weight percent lavender oil, about 0.005 to about 1 weight percent of rose oil, about 0.01 to about 2 weight percent cinnamon bark oil, about 0.01 to about 1 weight percent of coriander seed oil, about 0.7 to about 7 weight percent sorbitol, zero to about 7 weight percent isopropyl alcohol, about 5 to about 25 weight percent of propylene glycol, about 0.01 to about 2 weight percent butylated hydroxytoluene, about 0.05 to about 3 weight percent triethanolamine, about 0.01 to about 3 weight percent benzyl alcohol, about 0.01 to about 5 weight percent benzyl benzoate, about 1 to about 5 weight percent of polyethylene glycol (40)-hydrogenated castor oil, about 0.25 to about 4 weight percent acrylate/C10-30 alkyl acrylate crosspolymer, about 0.01 to about 0.2 weight percent disodium ethylene diamine tetraacetic acid, and the remainder water.

4. The topical composition of claim 3 and consisting essentially of, based on the weight of the composition: about 6 weight percent sweet almond oil, about 1 weight percent lavender oil, about 0.03 weight percent of rose oil, about 0.75 weight percent cinnamon bark oil, about 0.5 weight percent coriander seed oil, about 3.5 weight percent sorbitol, about 2.8 weight percent isopropyl alcohol, about 20 weight percent propylene glycol, about 1 weight percent butylated hydroxytoluene, about 1 weight percent triethanolamine, about 1 weight percent benzyl alcohol, about 1 weight percent benzyl benzoate, about 3.5 weight percent polyethylene glycol (40)-hydrogenated castor oil, about 1.3 weight percent acrylate/C10-30 alkyl acrylate crosspolymer, about 0.1 weight percent disodium ethylene diamine tetraacetic acid, and the remainder water.

Description

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

(1) The composition of the present invention is an oil-in-water emulsion comprising sweet almond oil, lavender oil, cinnamon bark oil, coriander seed oil and rose oil, preferably in a respective weight proportion of about 200:33:25:17:1. The oil-in-water emulsion is a viscous liquid or semi-solid having a cream-like consistency. The preferred dosage amount is approximately 150-300 mg of the composition per dose.

(2) Table 1 lists the components of the composition in recommended weight percent ranges, as well as the preferred weight percent.

(3) TABLE-US-00001 TABLE 1 Component wt % pfd wt % sweet almond oil.sup.1    2-10 6 lavender oil.sup.2 0.01-2 1 rose oil.sup.3 0.005-1  0.03 cinnamon bark oil.sup.4 0.01-2 0.75 coriander seed oil.sup.5 0.01-1 0.5 sorbitol  0.7-7 3.5 isopropyl alcohol   0-7 2.8 propylene glycol    5-25 20 butylated hydroxytoluene 0.01-2 1 triethanolamine 0.05-3 1 benzyl alcohol 0.01-3 1 benzyl benzoate 0.01-5 1 PEG 40-hydrogenated castor oil.sup.6   1-5 3.5 acrylate/C10-30 alkyl acrylate crosspolymer.sup.7 0.25-4 1.3 disodium EDTA .sup. 0.01-0.2 0.1 water q.s. to 100% q.s. to 100% .sup.1Prunus Amygdalus Dulcis oil .sup.2Lavandula Angustifolia oil .sup.3Rosa Damascena oil .sup.4Cinnamomun Zeylanicum bark oil .sup.5Coriandrum Sativum seed oil .sup.6Cremophor RH40 .sup.7Pemulen TR1

(4) The present compositions can be prepared in a batch process as described below.

(5) An aqueous dispersion is prepared using about 90 weight percent of required water, to which are added the acrylate crosspolymer and disodium ethylene diamine tetraacetic acid (EDTA). The resulting admixture is stirred until a substantially complete dispersion is achieved usually for about two hours. A 70 weight percent solution of sorbitol in water is then added with stirring, and the stirring is continued until a substantially homogeneous composition is obtained.

(6) A separate homogenous dispersion is prepared by admixing PEG 40-hydrogenated castor oil, benzyl alcohol, benzyl benzoate butylated hydroxytoluene, isopropanol and propylene glycol.

(7) The prepared dispersions are then quantitatively combined in a single vessel with stirring and the mixture of sweet almond oil, lavender oil, cinnamon bark oil, coriander seed oil and rose oil is added to the combined dispersions with stirring until a homogenous dispersion is produced. The stirring is continued for at least about one hour.

(8) A solution of triethanolamine in the remaining ten weight percent of water is then slowly added to the produced homogenous dispersion with stirring which is continued for at least 30 minutes to produce a smooth, cream-like composition.

EXAMPLE

(9) A cream prepared in the foregoing manner and containing the preferred amount of constituents shown in Table 1 was administered to eight circumcised male patients (age: 28 to 65 years). A dose of about 150 milligrams was applied to the glans penis twice a day for a two week period.

(10) Six of the eight patients reported that they experienced a lasting increased sensitivity of the glans penis after the two-week treatment period.

(11) A preferred method of use comprises application of the composition to the glans penis twice daily for at least about two weeks, preferably in an amount in the range of about 150 to about 300 milligrams per application. Thereafter a maintenance dose can be applied once a day to maintain a desired level of sensitivity.

(12) The foregoing description and the example are intended as illustrative and are not to be taken as limiting. Still other variants within the spirit and scope of the present invention are possible and will readily present themselves to those skilled in the art.