Preparation and method for the prophylaxis and treatment of atypical osteoporosis

Abstract

The invention related to medicine, in particular, to a method and a preparation for preventing and treating atypical osteoporosis with normal or increased bone tissue mineralization with the presence of cavities in trabecular bone sections (and conditions similar thereto involving excess mass and metabolic syndrome). The method comprises administrating a preparation comprising from 10 mg and 1000 mg of drone brood per day and from 50 IU and 100,000 IU of vitamin D or vitamins of the group D and/or active metabolites thereof per day. The preparation comprising drone brood and vitamin D or vitamins of the group D and/or active metabolites thereof can be in a powder, tablet or capsule form. The method and the preparation provide redistributing calcium in the body, reducing mineralization of soft tissues, vessels and other organs, and filling cavities in trabecular bone.

Claims

1. A method for preventing or treating atypical osteoporosis with normal or increased mineralization of bone tissue and the presence of cavities in trabecular bone sections, comprising the steps of: a) providing drone brood and at least one ingredient selected from the group consisting of vitamins of the group D and active metabolites thereof and b) administering to a patient in need the drone brood in an amount of from 10 mg to 1000 mg per day and the at least one ingredient selected from the group consisting of vitamins of the group D and active metabolites thereof in an amount of from 50 IU to 100,000 IU per day.

2. The method according to claim 1 wherein the drone brood and the at least one ingredient selected from the group consisting of vitamins of the group D and active metabolites thereof are administered simultaneously.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is a X-ray bone densitometry screenshot before treatment with the preparation according to Example 1;

(2) FIG. 2 is a X-ray bone densitometry screenshot after 9 months of treatment with the preparation according to Example 1;

(3) FIG. 3 is a X-ray bone densitometry screenshot before treatment with the preparation according to Example 2;

(4) FIG. 4 is a X-ray bone densitometry screenshot after 6 months of treatment with the preparation according to Example 2;

(5) FIG. 5 is a X-ray bone densitometry screenshot before treatment with the preparation according to Example 3;

(6) FIG. 6 is a X-ray bone densitometry screenshot after 6 months of treatment with the preparation according to Example 3;

(7) FIG. 7 is a X-ray bone densitometry screenshot before treatment with the preparation according to Example 4; and

(8) FIG. 8 is a X-ray bone densitometry screenshot after 6 months of treatment with the preparation according to Example 4.

(9) The technical result of the claimed invention consists in creating an agent that can facilitate the redistribution of calcium in the body: reducing mineralization in soft tissues, vessels and other organs, and which could also facilitate the filling of trabecular bone cavities.

(10) This result is achieved in that in the method for preventing and treating atypical osteoporosis with normal or increased bone tissue mineralization with the presence of cavities in trabecular bone sections (and conditions similar thereto involving excess mass and metabolic syndrome), involves taking between 10 mg and 1000 mg per day of drone brood, between 50 IU and 100,000 IU per day of vitamin D or vitamins of this group and/or the active metabolites thereof; and a preparation for the prevention and treatment of atypical osteoporosis with normal or increased bone tissue mineralization with the presence of cavities in trabecular bone sections (and conditions similar thereto involving excess mass and metabolic syndrome), which consists of between 10 mg and 1000 mg of drone brood and between 50 IU and 100,000 IU of vitamin D or vitamins of this group and/or the active metabolites thereof, and according to the invention drone brood, vitamin D or vitamins of this group and/or the active metabolites thereof are supplied to the body at the same time daily, and the preparation is provided in powder, tablet or capsule form.

(11) The method for preventing and treating atypical osteoporosis with normal or increased bone mineral density with the presence of cavities in trabecular bone sections (and conditions similar thereto involving excess mass and metabolic syndrome) is carried out in the following way.

(12) In order to solve the problem of interest, the authors have created and tested on volunteers an agent in a composition with the ratio of ingredients: between 50 IU and 100,000 IU per day of vitamin D or vitamins of this group (and/or the active metabolites thereof); and between 10 mg and 1000 mg per day of drone brood.
The claimed agent can be provided in powder, tablet or capsule form.

(13) Vitamin D is included because drone brood is saturated with vitamins in particular vitamin D3, but in non-replacing, small doses. Therefore, the concentration thereof is insufficient for treating osteoporosis.

(14) Drone brood has to be introduced as a donor of the following sex hormones: estradiol, progesterone and testosterone, which have a positive effect on bone mineralization.

(15) The scope of the range of the claimed preparation is determined by the characteristics of the patient: their age, eating habits, lifestyle, race, country of habitation, sex and genetic and previous diseases. A doctor assessing these criteria selects the specific proportion of the constituent parts of the claimed agent and adjusts this based on a change regarding cavity closures.

(16) An explanation of the range limits:

(17) 1) Between 50 IU and 100,000 IU per day of vitamin D or vitamins from this group (and/or the active metabolites thereof). The lower end is the effective dose while the upper end is a toxic dose.

(18) 2) Between 10 mg to 1000 mg per day of drone brood. The lower end is the effective dose while the upper end is the feasibility of use in terms of the ratio of effectiveness/price rise of the product.

(19) The studies have established that using the claimed preparation strengthens the mechanism for the uniform restoration of bone mineral density, the use of drone brood in combination with vitamin D additionally aims to enhance the remodelling of injured bone tissue sections and for bone tissue retention by maintaining androgen levels.

(20) The combined use of vitamin D with drone brood makes it possible to achieve the greatest effectiveness in osteoporosis therapy in patients with hypercalcaemic conditions, to reduce the frequency of adverse side effects in the form of calcified deposits and stones forming in the kidneys and in other organs.

(21) Although the components of the claimed preparation are known in folk and traditional medicine, the combination thereof in one product is not known, specifically, the discovered synergistic effect makes it possible to solve the problem of balanced bone mineralization in both trabecular bone sections and cortical bone sections and to solve the problem of interest and to achieve the claimed technical result, namely to eliminate or reduce an imbalance in the mineralization of various bone tissue sections.

(22) Examples of closing cavities using the homogenate of drone brood and vitamin D3 in patients with hypermineralization:

(23) Example No. 1: Patient FAD. 64 years of age with postmenopausal osteoporosis. The patient took ‘Kaltsii D3 forte’ made by the company ‘NIKOMED’ for a year. She has been diagnosed with hypermineralization, salt deposits in her soft tissues. Despite this condition, the patient has cavities. She was prescribed treatment with the claimed agent in a composition in the form of a powder mixture: 1000 mg of drone brood+100 IU of vitamin D3 per day.

(24) The results before and after treatment are shown in FIG. 1.

(25) The picture of the beginning of treatment clearly shows salt deposits in soft tissues, which indicates hypermineralization. These are orange in the picture on a white background between two bones.

(26) The results after 9 months of treatment are shown in FIG. 2.

(27) It can be seen that the claimed agent reduces salt deposits and closes the cavities. In other words, the calcium was redistributed within the body.

(28) Example No. 2. Female patient Z. 66 years old with postmenopausal osteoporosis. The patient took ‘Kaltsii D3 forte’ made by the company ‘NIKOMED’ for 9 months. She has been diagnosed with hypermineralization, salt deposits in her soft tissues. Despite this condition, the patient has cavities. She was prescribed treatment with the claimed agent in a composition in the form of a powder mixture: 500 mg of drone brood+2500 IU of vitamin D3 per day.

(29) The results before and after the 6 month course of treatment are shown in FIG. 3, 4.

(30) The results before treatment with the claimed mixture are shown in FIG. 3.

(31) The results after a six-month treatment with the claimed mixture are shown in FIG. 4.

(32) The cavities were reduced and the salt deposits in the soft tissues disappeared.

(33) Example No. 3. Female patient Z 1. 70 years old with postmenopausal osteoporosis. The patient took ‘Kaltsii D3 forte’ made by the company ‘NIKOMED’ for 12 months. She has been diagnosed with hypermineralization, salt deposits in her soft tissues. Despite this condition, the patient has large cavities. She was prescribed treatment with the claimed agent in a composition in the form of a powder mixture: 500 mg of drone brood+100,000 IU of vitamin D2 per day.

(34) The results before and after the 6 month course of treatment are shown in FIG. 5, 6.

(35) The results before treatment with the claimed mixture are shown in FIG. 5.

(36) The results after treatment with the claimed mixture are shown in FIG. 6.

(37) As the picture shows, the cavities closed, but the salt deposits in the soft tissues did not completely disappear, which indicates a large dose of vitamin D2 for this patient.

(38) Regarding the range for using vitamin D and the active metabolites thereof, it should be noted that various forms of vitamin D have various degrees of therapeutic activity. Thus, vitamin D2 is weaker than vitamin D3, and therefore a greater amount of D2 is required in comparison to vitamin D3. The same is true regarding vitamin D metabolites.

(39) Example No. 4: The ineffectiveness of the claimed agent is lower than the low limit: Female patient D. 60 years of age with postmenopausal osteoporosis. The patient took ‘Kaltsii D3 forte’ made by the company ‘NIKOMED’ for 6 months. She has been diagnosed with hypermineralization, salt deposits in her soft tissues. She does not have any cavities. She was prescribed treatment with the claimed agent in a composition in the form of a powder mixture: 9 mg of drone brood+40 IU of vitamin D2 per day.

(40) The results before and after the 6 month course of treatment are shown in FIG. 7, 8.

(41) The results before treatment with the claimed mixture are shown in FIG. 7.

(42) The results after treatment are shown in FIG. 8.

CONCLUSION

(43) there are no significant changes, the bone mineral density has been reduced, the mineral deposits have also proportionally reduced.

(44) When prescribing the claimed agent, the doctor chooses the dosage of the constituent parts thereof individually based on the condition of the disease of the patient. The condition of the patient should be assessed with the aid of density measuring apparatuses measuring the cavities every 6-9 months and adjusting the composition of the claimed agent used.