COMPOSITION FOR SLOWING CELLULAR AGEING, ASSOCIATED FOOD SUPPLEMENT

Abstract

The invention relates to a composition for slowing cellular ageing which comprises at least: S-Adenosyl-methionine; an extract of at least one adaptogenic plant selected among plants belonging to the Astragalus, Dioscorea, Schisandra, Panax, Eleuterococcus, Rosmarinus, Pfaffia, Morinda, Cordyceps or Lepidium genera; a vitamin selected among the B vitamins, vitamin C, or a mixture thereof; except for compositions comprising 7-keto-DHEA and an extract of one or more adaptogenic plants belonging to the Dioscorea or Lepidium genera. A liquid or solid food supplement can be characterised in that it comprises the composition. A dermatologically acceptable composition can be characterised in that it comprises at least 10 wt % of the composition.

Claims

1. Composition for slowing cell aging comprising at least: S-Adenosyl-methionine an extract of at least one adaptogenic plant chosen from plants belonging to the Astragalus, Dioscorea, or Lepidium genera, a vitamin chosen from vitamins in the B group, vitamin C, or a mixture thereof; excluding compounds comprising 7-keto-DHEA and an extract of one or more adaptogenic plants belonging to the Dioscorea or Lepidium genera.

2. Composition according to claim 1, characterised in that said adaptogenic-plant extract comprises: saponins chosen from type I to VIII astragalosides, preferably of type I, II, III and/or IV, cycloastragenol.

3. (canceled)

4. Composition according to claim 1, characterised in that said adaptogenic plant or plants is or are chosen from the plants belonging to the Astragalus genus.

5. Composition according to claim 1, characterised in that the vitamin in the B group is chosen from vitamins B6, B9, B12 or a mixture thereof

6. Composition according to claim 1, characterised in that said composition also comprises a magnesium salt.

7. Composition according to claim 1, characterised in that it comprises at least: between 0.01% and 70% by weight S-Adenosyl-methionine, between 0.01% and 45% by weight adaptogen-plant extract, between 0.01% and 40% by weight magnesium salt, between 0.01% and 25% by weight vitamins.

8. Composition according to claim 1, characterised in that said composition is in the form of an oil in water or water in oil emulsions, an aqueous or oily gel, a solid or any other form suitable for topical, oral or injectable administration.

9. Composition according to claim 1, characterised in that, when said composition is in the form of a solid mixture able to be introduced in a capsule, said composition comprises: 45% by weight S-Adenosyl-methionine 18% by weight adaptogen-plant extract, 35% by weight magnesium salt, 1% by weight vitamins.

10. Liquid or solid food supplement, characterised in that it comprises a composition according to claim 1.

11. Dermatologically acceptable composition, comprising at least 80% by weigh of a composition according to claim 1.

Description

DETAILED DESCRIPTION OF VARIOUS EMBODIMENTS OF THE INVENTION

[0054] Numerous combinations can be envisaged without departing from the scope of the invention; a person skilled in the art will choose one or the other according to economic, ergonomic, dimensional or other constraints that he will have to comply with.

Composition According to the Invention in the Form of a Food Supplement:

[0055] 1

[0056] One embodiment of the invention is a food supplement in the form of an acid-resistant gelatine capsule (DR-caps from Casugel) able to contain in solid form: [0057] 250 mg of SAM (Laboratoire Prophar-Angers), [0058] 100 mg of a 20% dry extract of Astragalus membranaceus (Laboratoire Prophar-Angers), [0059] 200 mg of magnesium oxide of marine origin (Laboratoire Prophar-Angers), [0060] 4 mg of vitamin B6 representing 300% of the recommended daily intake (RDI) (Laboratoire Prophar-Angers), [0061] 800 μg of vitamin B12 (Laboratoire Prophar-Angers).

Composition According to the Invention in the Form of a Food Supplement:

[0062] 2

[0063] Another example embodiment of a food supplement in the form of an acid-resistant gelatine capsule according to the invention is as follows: [0064] 250 mg of SAM (Laboratoire Prophar-Angers), [0065] 200 mg of Dioscorea opposita in 20% dry extract (Laboratoire Prophar-Angers), [0066] 150 mg of magnesium oxide of marine origin (Laboratoire Prophar-Angers), [0067] 800 μg of vitamin B9, representing 200% of the recommended daily intake (RDI) (Laboratoire Prophar-Angers), [0068] 600 μg of vitamin B12 (Laboratoire Prophar Angers).

Composition According to the Invention in the Form of a Food Supplement:

[0069] 3

[0070] Another example of an embodiment of a food supplement in the form of an acid-resistant gelatine capsule according to the invention is as follows: [0071] 250 mg of SAM (Laboratoire Prophar-Angers), [0072] 200 mg of a 20% dry extract of Astragalus membranaceus (Laboratoire Prophar-Angers), [0073] 200 mg of Dioscorea villosa in a 20% dry extract (Laboratoire Prophar-Angers), [0074] 300 mg of magnesium oxide of marine origin (Laboratoire Prophar-Angers), [0075] 2 mg of vitamin B6 representing 200% of the recommended daily intake (RDI) (Laboratoire Prophar-Angers), [0076] 400 μg of vitamin B12 (Laboratoire Prophar-Angers).

Composition According to the Invention in the Form of a Food Supplement:

[0077] 4

[0078] Another example of an embodiment of a food supplement in the form of an acid-resistant gelatine capsule according to the invention is as follows: [0079] 250 mg of SAM (Laboratoire Prophar-Angers), [0080] 100 mg of a 20% dry extract of Astragalus membranaceus (Laboratoire Prophar-Angers), [0081] 100 mg of Dioscorea villosa in a 20% dry extract (Laboratoire Prophar-Angers), [0082] 300 mg of Lepidium meyenii in a 20% dry extract (Laboratoire Prophar-Angers), [0083] 300 mg of magnesium glycerophosphate of marine origin (Laboratoire Prophar-Angers), [0084] 2 mg of vitamin B6, representing 200% of the recommended daily intake (RDI) (Laboratoire Prophar-Angers), [0085] 500 μg of vitamin B9 (Laboratoire Prophar-Angers), [0086] 400 pg of vitamin B12 (Laboratoire Prophar-Angers).

Composition According to the Invention in the Form of a Dermatologically Acceptable Composition

[0087] Another embodiment of the invention is a dermatologically acceptable composition in the form of a gel or emulsion, comprising at least 10% by weight, in particular at least 30% by weight, more preferentially at least 80% by weight, of a composition A according to the invention.

[0088] Preferentially, when a vehicle of the gel or oil type is used, the adaptogenic-plant extract used is then a hydroglycerin extract of a part of the plant such as the leaves, roots or stem, or a hydroglycerin extract of the entire plant.

[0089] For example, a dermatologically acceptable composition for cosmetic purposes comprises: [0090] 10% to 90% by total weight, for example 20% by total weight, of a vehicle of the non-alcoholic solid gel type, in the form of a bar or stick, and [0091] 10% to 90% by total weight, for example 80% by total weight, of a composition A according to the invention.

[0092] Said vehicle of the non-alcoholic solid cosmetic gel type, in the form of a bar or stick, comprises for example: [0093] 65% to 99% by weight of the vehicle of a polyol, chosen from glycerol, polyglycerol, polyethylene glycol, propylene glycol, sorbitol, alcohol ethers or a mixture of these, [0094] 0.1% to 5% by weight of a dibenzylidene-ose, [0095] 0.1% to 5% by weight of a hardening agent of the sulfosuccinate type, for example a silicone succinate at a concentration of between 1% and 1% by weight, [0096] 0.5% to 40% by weight water.

[0097] Said composition A according to the invention may comprise for example: [0098] 55% by weight S-Adenosyl-methionine, [0099] 35% by weight hydroglycerin extract of Dioscorea opposita and/or villosa, [0100] 10% by weight vitamin C or natural ascorbic acid, extract of acerola.

[0101] Another example of composition A is as follows: [0102] 40% by weight S-Adenosyl-methionine, [0103] 35% by weight hydroglycerin extract of Dioscorea villosa, [0104] 25% by weight vitamin C or natural ascorbic acid, extract of acerola.

[0105] In addition, in such dermatologically acceptable compositions, it is possible to incorporate active agents, or additional molecules of interest, such as perfumes, fragrances, preservatives, antioxidants, hydrating agents, anti-inflammatory agents, UV filters, as well as dyes, in a proportion of between 0.1% and 40% by total weight of said dermatologically acceptable composition. These active agents or additional molecules of interest neither alter nor affect the required properties of said dermatologically acceptable composition.

[0106] Such compositions according to the invention can be used in a protocol intended to combat or slow down the pathological or physiological signs of chronological and/or induced aging, such as the appearance of wrinkles, lines, loss of skin firmness, loss of skin elasticity, actinic keratosis, actinic moles, nervous degeneration characterised by the appearance of neurodegenerative illnesses such as Alzheimer's, Parkinson's, Huntington's Chorea or motor neurone disease, decline in cognitive functions, such as memory loss, depression, or signs of aging associated with osteoporosis; hepatic and/or digestive functional impairment; joint problems of cartilaginous or inflammatory origin such as rheumatoid polis arthritis; chronic inflammatory problems and any type of impairment or disease related to premature aging.