CHEMICAL ANALYSIS OF URINE AND FECES VAPOR

Abstract

A gas sensor system is for use in, or in the vicinity of, a toilet, for detecting a target gas. A gas sensor detects a concentration of at least the target gas and a further, reference, gas which is received from a controlled gas release device. These concentrations are processed to obtain a concentration of the target gas relative to the concentration of the further gas by combining a change in the detected concentration of the target gas, a change in the detected concentration of the further gas, the sensitivity of the gas sensor system to the target gas and the sensitivity of the gas sensor system to the further gas. This approach avoids the need for extensive calibration operations to tune the sensor response to the environment in which it is used.

Claims

1. A gas sensor system for use in or in the vicinity of a toilet, for detecting a target gas arising from use of the toilet, comprising: a gas sensor for detecting a concentration of at least the target gas and a further gas, wherein the further gas is received from a controlled gas release device for releasing the further gas at a controlled rate; and a controller for processing the detected concentration of the target gas and the further gas, wherein the controller is adapted to obtain a concentration of the target gas relative to the concentration of the further gas by combining: a change in the detected concentration of the target gas; a change in the detected concentration of the further gas; the sensitivity of the gas sensor system to the target gas; and the sensitivity of the gas sensor system to the further gas.

2. The system as claimed in claim 1, wherein the sensor is adapted to detect a target gas which comprises ammonia, acetone, nitric oxide or other volatile organic compounds.

3. The system as claimed in claim 1, wherein the controller is adapted to assume a known baseline concentration for the further gas, and is adapted to obtain a concentration of the target gas relative to the baseline concentration thereby to determine a calibrated concentration of the target gas.

4. The system as claimed in claim 1, comprising the controlled gas release device for releasing the further gas at a controlled rate.

5. The system as claimed in claim 4, wherein the controlled gas release device comprises an air freshener device which is in the vicinity of the toilet.

6. The system as claimed in claim 4, wherein the controller is adapted to determine the concentration Ca of the target gas relative to the baseline concentration Cr of the further gas as:
Ca/Cr=(∫[a(t)−a0]dt/∫[r0−r(t)]dt)Sr/Sa in which a0 is a sensed concentration of the target gas at the start of a sensing cycle, a(t) is the sensed concentration of the target gas over time, r0 is a sensed concentration of the further gas at the start of the sensing cycle, r(t) is the sensed concentration of the further gas over time, Sa is the sensitivity of the sensor to the target gas and Sr is the sensitivity of the sensor to the further gas, and wherein the integration is over a sensing time period.

7. The system as claimed in claim 1 wherein the gas sensor is adapted to detect a concentration of two or more target gases.

8. The system as claimed in claim 7, wherein the gas sensor is adapted to detect a concentration of a second target gas which comprises ammonia, acetone, nitric oxide or other volatile organic compounds, different to the first target gas.

9. The system as claimed in claim 1, wherein the sensor comprises an electronic nose.

10. A gas sensing method for detecting a target gas system in or in the vicinity of a toilet and arising from use of the toilet, comprising: receiving the target gas, and receiving a further gas from a controlled gas release device which releases the further gas at a controlled rate; detecting a concentration of at least the target gas and the further gas; processing the detected concentration of the target gas and the further gas, thereby to obtain a concentration of the target gas relative to the concentration of the further gas by combining: a change in the detected concentration of the target gas; a change in the detected concentration of the further gas; the sensitivity of the gas sensor system to the target gas; and the sensitivity of the gas sensor system to the further gas.

11. The method as claimed in claim 10, wherein the target gas comprises ammonia, acetone, nitric oxide or other volatile organic compounds.

12. The method as claimed in claim 10, wherein the further gas has a known baseline concentration and the method comprises obtaining a concentration of the target gas relative to the baseline concentration thereby to determine a calibrated concentration of the target gas.

13. The method as claimed in claim 12, wherein the concentration Ca of the target gas relative to the baseline concentration Cr of the further gas is obtained as:
Ca/Cr=(∫[a0−a(t)]dt/∫[r(t)−r0]dt)Sr/Sa in which a0 is a sensed concentration of the target gas at the start of a sensing cycle, a(t) is the sensed concentration of the target gas over time, r0 is a sensed concentration of the further gas at the start of the sensing cycle, r(t) is the sensed concentration of the further gas over time, Sa is the sensitivity of the has sensor to the target gas and Sr is the sensitivity of the sensor to the further gas, and wherein the integration is over a sensing time period.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Examples of the invention will now be described in detail with reference to the accompanying drawings, in which:

[0046] FIG. 1 shows a toilet which houses a sensor system in accordance with an example of the invention;

[0047] FIG. 2 shows sensor signals and is used to explain different processing approaches in accordance with examples of the invention;

[0048] FIG. 3 shows a sensor signal processing method in accordance with an example of the invention; and

[0049] FIG. 4 shows a sensor system in accordance with an example of the invention.

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0050] The invention provides a gas sensor system for use in, or in the vicinity of, a toilet, for detecting a target gas. A gas sensor detects a concentration of at least the target gas and a further gas which is received from a controlled gas release source. This further gas functions as a reference gas. These concentrations are processed to obtain a concentration of the target gas relative to the concentration of the further gas by combining a change in the detected concentration of the target gas, a change in the detected concentration of the further gas, the sensitivity of the gas sensor system to the target gas and the sensitivity of the gas sensor system to the further gas. This approach avoids the need for extensive calibration operations to tune the sensor response to the environment in which it is used.

[0051] The invention may be implemented as electronic nose-based system and method, for assessment of changes in urine or feces gas concentration, for example to track changes in a person's hydration status. The invention can also be applied for other biomedical purposes in which the concentration of a specific biomarker is important rather than only its presence.

[0052] The system enables the use of e-nose technology to quantify the concentration of target gases in larger rooms (like the toilet) with undefined environment. This eliminates the need for sampling of urine or feces and/or contact with the sample and therefore allows integration into a regular toilet block-like embodiment, for example hanging on the inside of the toilet while using the toilet in a normal fashion. The system is capable of automatic and quantitative analysis of different urine/feces components, and may then provide real-time information of the physiological/health condition of the toilet's user.

[0053] FIG. 1 shows a toilet 10.

[0054] A first set of examples make use of a gas release device 12 which is suspended in the toilet bowl. The gas release device is adapted to provide a controlled release of a reference gas. In one example, the gas release device is a toilet freshener, and the reference gas is a part of the toilet freshener gases. Alternatively, the gas release device may release a gas which has no odor and is instead chosen only because it can be sensed easily. In this case, the gas release device does not need to perform a toilet freshening function.

[0055] The gas release device releases the reference gas into the volume of the toilet bowl.

[0056] The housing for the gas release device (e.g. toilet freshener) also includes a gas sensor, for example in the form of an electronic nose. The gas sensor is thus for use in the toilet bowl or at least in the vicinity of the toilet. It is for detecting at least two gases.

[0057] A second concept does not make use of a reference gas, but instead is based on detection of two target gases.

[0058] This second concept may be used with only a sensor system, and with no need for a gas release device such as a toilet freshener. However, this second concept may be combined with the gas release device method described above to provide additional measurement options.

[0059] In the examples above, there is sensing of at least two gases. A first gas is a target gas, the concentration of which is of interest for providing a health diagnosis. A second (further) gas is a reference gas, as mentioned above. In an example which makes use of a toilet freshener, the second gas can be an air freshener gas produced by the toilet freshener. This functions as a reference gas.

[0060] In the second concept, a first gas is a target gas. A second (further) gas is another target gas, and the detection of the two gases may be used to obtain a measure of relative concentration. The additional use of a reference gas as in the examples above enables conversion to absolute concentration values

[0061] The gas sensor can be a single device capable of detecting multiple gases or it can be multiple separate electronic gas sensors, each for a specific gas detection.

[0062] The sensor gives a “detected concentration” result. This would need to be calibrated in order to derive real concentration values. Thus, the term “detected” concentration is used to refer to a sensor reading. In the approach of this invention, the detected concentration of the target gas and the detected concentration of the second, reference, gas are processed to obtain a real i.e. calibrated concentration of the target gas relative to the real concentration of the further, reference, gas by monitoring changes in the detected concentration of the target gas and changes in the detected concentration of the further gas. The sensitivities of the gas sensor system to the two gases are also used.

[0063] The target gas (or each target gas if there are multiple target gases) may for example comprise ammonia, acetone, nitric oxide or volatile organic compounds.

[0064] FIG. 1 also shows the toilet seat provided with a weighing scale system 14. As discussed further below, this is one possible way for automatic detection of which user (within the household) is using the toilet. Other ways are of course possible, including manual input by the use of their identity. The use of weight measurement can also give additional information of interest for interpreting the sensor signals. For example, weight loss can be monitored to estimate urine output. Furthermore, using a smart analysis of the weight decay curve, it may also be possible to distinguish between defecation (sudden drop in weight) and urination (gradual decline in weight).

[0065] The signal output of the gas sensor is for example analysed by pattern recognition algorithms.

[0066] The reference gas occupies the toilet space with a known real concentration. When the toilet is used, a part of the reference gas is replaced by urine/feces gas. By measuring both the lowering of the reference gas concentration and the rise in the gas concentration of the urine/feces vapor, the concentration of the molecule of interest can be determined.

[0067] This ratio based method enables the use of e-nose technology to quantify the concentration of a molecule of interest in a toilet, regardless of for example the toilet room size and thus vapor dilution or temperature.

[0068] The gas sensor comprises an encased array of sensor elements. In the examples which makes use of a gas release device, the gas sensor may be integrated into the housing of the gas release device (e.g. toilet freshener block), so as to come in contact with urine/feces gas flow in the toilet. Sensors suitable for detection of urine/feces gases can be based on conducting and non-conducting materials, arranged in a matrix of conducting and non-conducting regions, e.g. metal oxide field effect transistor (MOSFET), piezoelectric devices, etc.

[0069] Each sensor element in the array has different characteristics. The compounds of interest are adsorbed on the sensor surface and transient response is produced as the compounds from the gas interact with the active material at the surface of the sensor. A specific response is recorded by the electronic interface.

[0070] The pattern of response across all the sensor elements in the array is used to characterize and identify a particular target gas.

[0071] Examples of the analysis are given below based on the sensing of two gases. However, the approach can be extended to more gases, and this may lead to more accurate results and/or more possible diagnostic information to be derived.

[0072] FIG. 2 shows an illustration of an example measurement. The variations in concentration are shown exaggerated for clarity.

[0073] The three plots r(t), a(t) and b(t) are gas sensor signals for gases r, a and b. These show detected concentration levels. However, the way these detected levels correlate to the true concentration will depend on the nature of the sensing volume. Component r(t) is a reference component that comes from the sensor unit itself, namely the air freshener gas as explained above.

[0074] It has a constant concentration, giving rise to the signal r.sub.0 leading up to the beginning of toilet use at time t1.

[0075] Components a(t) and b(t) are target gases which are associated with urine or feces. They each have a different baseline value a0 and b0 which represents their concentration in air (or in the reference gas if used). Components a(t), b(t) and r(t) all change during toilet use.

[0076] The background levels of the reference gas r lower, while the levels of a and b rise. As shown in FIG. 2, the two target gases a and b have different concentrations and/or they are associated with different gas sensor sensitivities. The detected reference gas concentration drops by at most Δr, while the detected target gas concentrations increase by at most Δr and Δb.

[0077] When the system is based on the analysis of one target gas a and the reference gas r, the concentration of, for example, component a, Ca, can be determined via:

Ca=Cr(∫[a(t)−a0]dt/∫[r0−r(t)]dt)Sr/Sa

[0078] Cr is the known baseline concentration of the reference gas r and Sr and Sa are the sensitivities of the sensor array to the components r and a, respectively.

[0079] The integration can be performed over the whole period associated the toilet use or during a specific phase of the toilet use.

[0080] Alternatively, the second concept outlined above may be used. Instead of calculating the ratio between the appearance of the target gas and the reduction of the reference gas, the ratio between two markers in the urine and/or feces can be calculated to detect disturbances in urine concentration.

[0081] In this case, the signal processing is based on signals a and b.

[0082] In this case, the relative concentration of the two target gases can be given by:

Ca/Cb=(∫[a(t)−a0]dt/∫[b(t)−b0]dt)Sb/Sa

[0083] Again, the integration can be done over the whole period associated the toilet use or during a specific phase of the toilet use.

[0084] This is of interest if the ratio between two target gases provides information of diagnostic interest. However, the absolute concentrations may then also be obtained in the manner explained above by making use of a reference gas.

[0085] These integration functions provide the area between the curves and their respective baselines, representing a total concentration change over time (with units of concentration×time). An alternative is to process the maximum concentration change values Δr, Δa and Δb (with units of concentration).

[0086] FIG. 3 shows the processing method, based on the use of a reference gas sensor.

[0087] In (optional) step 30, the user of the toilet is identified by a user interface (“UI”). As mentioned above, this may be based on a detected weight of the user, although this will only be appropriate for a small number of possible users with different weights. For home use, this will be likely, whereas for use in a care home, for example, this may not be appropriate. If there is only one user of the toilet (e.g. an en-suite toilet) then no user identification is needed.

[0088] A user may instead identify themselves by pressing a button allocated to them on the toilet, or there may be automatic recognition based on wireless recognition of an identity device (such as an RFID tag) carried by the user. The user may identify themselves by operating an application on their mobile phone which advises the system of the user identity. The system can then track trends associated with individual users.

[0089] In step 32, the baseline values a0 and r0 are measured and the sensor detections signals r(t) and a(t) are measured.

[0090] In step 34, the integrations are carried out.

[0091] In step 36, the ratio between the integration results is obtained.

[0092] In step 38, correction based on the sensitivity values Sr and Sa is made.

[0093] In step 40, the multiplication by the known reference baseline concentration is carried out, to provide the concentration Ca in step 42.

[0094] In step 44 a comparison is made with a reference value or values, so that in step 46 a diagnosis can be made. These reference values are for example obtained from a ‘normal’ population or they can be obtained during previous toilet visits.

[0095] In step 48, an output system provides information of a diagnostic relevance to the patient or to a caregiver. This can then be used to make a diagnosis or monitor disease progression. This may comprise an upload to a mobile phone application, or a display output, or generation of a text or email message. Any suitable user interface can be used to deliver information to the patient or a caregiver.

[0096] FIG. 4 shows one example of the the system.

[0097] The gas sensor system 50 has at least two sensor elements 52, which may be separate sensors or different sensing regions of a single sensor. The system optionally receives an input form a user interface 54 which identifies the user, as discussed above.

[0098] The gas sensor signals are provided to a controller 56, such as a microprocessor 56, which implements the algorithms explained above. It may additionally implement a diagnostic analysis, although the diagnostic analysis can instead be performed later based on the information of diagnostic relevance which is generated by the system.

[0099] The information to be output, which may be the concentration information Ca and Cb, or the full sensing data (i.e. r(t), a(t) and b(t)), or the diagnosis information for example relating to a level of hydration, is transmitted to the user. In the example shown, this is by a wireless link 58 to a mobile telephone 60 of the user.

[0100] The invention proposes an unobtrusive system and method which enables real-time urine or feces gas analysis to be carried out. It may also perform real time analysis and diagnostic analysis to monitor the health condition of the toilet user, such as the hydration level.

[0101] The problem of e-nose technology, that knowledge of the environment in which the e-nose is used (temperature, air composition, volume, flow, distance to source) conventionally needs to be known, is addressed. The use of e-nose technology is thus able to be used to quantify the concentration of target substances in larger rooms (like the toilet) with undefined and variable environment.

[0102] The invention can be used for monitoring a range of conditions. One important application is dehydration monitoring for the elderly at home. The concentration of ammonia in urine (which one can smell very well), is directly proportional to the extent of dehydration. Furthermore, if urine is particularly pungent, for example with an ammonia scent, it can be due to an infection or urinary stones. Menopause, some sexually transmitted diseases, and certain metabolic disorders may also increase the ammonia scent. Diabetics might notice that their urine smells sweet, because of excess sugar. Also some genetic conditions causes urine to smell sickeningly sweet. Foul smelling urine may be due to bacterial infection and musty smelling urine can be related to liver diseases and certain metabolic disorders.

[0103] Multiple groups have used electronic nose technology for recognition of disease in vivo. Identification of unique molecular markers, volatile metabolites, associated with particular diseases is an extremely effective and powerful tool for the early detection of diseased tissues and infectious agents in the human body. Examples of descriptive aromas have been documented in numerous reports that associate connections between (un)usual specific human odors or aromas and particular human diseases and disorders, e.g. musty fish aroma breath can be related to liver failure, ammonia smell in urine can be linked to bladder infections, etc.

[0104] As discussed above, embodiments make use of a controller. The controller can be implemented in numerous ways, with software and/or hardware, to perform the various functions required. A processor is one example of a controller which employs one or more microprocessors that may be programmed using software (e.g., microcode) to perform the required functions. A controller may however be implemented with or without employing a processor, and also may be implemented as a combination of dedicated hardware to perform some functions and a processor (e.g., one or more programmed microprocessors and associated circuitry) to perform other functions.

[0105] Examples of controller components that may be employed in various embodiments of the present disclosure include, but are not limited to, conventional microprocessors, application specific integrated circuits (ASICs), and field-programmable gate arrays (FPGAs).

[0106] In various implementations, a processor or controller may be associated with one or more storage media such as volatile and non-volatile computer memory such as RAM, PROM, EPROM, and EEPROM. The storage media may be encoded with one or more programs that, when executed on one or more processors and/or controllers, perform at the required functions. Various storage media may be fixed within a processor or controller or may be transportable, such that the one or more programs stored thereon can be loaded into a processor or controller.

[0107] As explained above, a second concept is to measure the relative concentration between two target gases. In this case, there is provided a gas sensor system for use in or in the vicinity of a toilet, for detecting a concentration ratio between two target gases, comprising:

[0108] a gas sensor for detecting a concentration of the first and second target gases, and

[0109] a controller for processing the detected concentration of the first and second target gases, wherein the controller is adapted to obtain a concentration of the first target gas relative to the concentration of the second target gas by combining:

[0110] a change in the detected concentration of the first target gas;

[0111] a change in the detected concentration of the second target gas;

[0112] the sensitivity of the gas sensor system to the first target gas; and

[0113] the sensitivity of the gas sensor system to the second target gas.

[0114] The concentration Ca of the first target gas relative to the concentration Cb of the second target gas is obtained as:

Ca/Cb=(∫[a0−a(t)]dt/∫[b(t)−b0]dt)Sb/Sa

in which a0 is a sensed concentration of the first target gas at the start of a sensing cycle, a(t) is the sensed concentration of the first target gas over time, b0 is a sensed concentration of the second target gas at the start of the sensing cycle, b(t) is the sensed concentration of the second target gas over time, Sa is the sensitivity of the has sensor to the first target gas and Sb is the sensitivity of the sensor to the second target gas, and wherein the integration is over a sensing time period.

[0115] Other variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing the claimed invention, from a study of the drawings, the disclosure, and the appended claims. In the claims, the word “comprising” does not exclude other elements or steps, and the indefinite article “a” or “an” does not exclude a plurality. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measured cannot be used to advantage. Any reference signs in the claims should not be construed as limiting the scope.