STERILISATION APPARATUS FOR PRODUCING PLASMA AND HYDROXYL RADICALS

Abstract

Sterilization systems suitable for clinical use, comprising: a housing defining a water mist fluid flow path between an inlet for receiving water mist and an outlet for directing a flow of hydroxyl radicals towards a region to be sterilised; an energy delivery tip configured to produce a thermal or non-thermal plasma; a coaxial transmission line arranged to convey radiofrequency (RF) and/or microwave frequency electromagnetic (EM) energy; and a gas conduit in the housing and arranged to deliver gas to the energy delivery tip, wherein the energy delivery tip extends from a distal end of the coaxial transmission line. The energy delivery tip comprises: a first electrode; and a second electrode. The first electrode and second electrode are configured to: strike a plasma in the gas delivered to the energy delivery tip, and direct the plasma into the water mist fluid flow path to form hydroxyl radicals therein.

Claims

1. A sterilisation device for generating a flow of hydroxyl radicals, the sterilisation device comprising: a housing defining a water mist fluid flow path between an inlet for receiving water mist and an outlet for directing a flow of hydroxyl radicals towards a region to be sterilised; an energy delivery tip configured to produce a thermal or non-thermal plasma; a coaxial transmission line mounted in the housing and arranged to convey radiofrequency (RF) or microwave frequency electromagnetic (EM) energy to the energy delivery tip; and a gas conduit mounted in the housing and arranged to deliver gas to the energy delivery tip, wherein the coaxial transmission line comprises an inner conductor, an outer conductor, and a dielectric material separating the inner conductor from the outer conductor, wherein the energy delivery tip extends from a distal end of the coaxial transmission line, and wherein the energy delivery tip comprises: a first electrode electrically connected to the inner conductor of the coaxial transmission line; and a second electrode electrically connected to the outer conductor of the coaxial transmission line, wherein the second electrode is configured to define an internal volume of the energy delivery tip, wherein the first electrode extends longitudinally within the internal volume, wherein the first electrode and second electrode are configured to: strike a plasma in the gas delivered to the energy delivery tip, and direct the plasma into the water mist fluid flow path to form hydroxyl radicals therein.

2. A sterilisation device according to claim 1, wherein the energy delivery tip is located within the housing.

3. A sterilisation device according to claim 2, wherein the first electrode and second electrode define an exit from the internal volume, wherein the exit is located at or in the outlet.

4. A sterilisation device according to claim 1, wherein the first electrode is formed from a length of the inner conductor that extends beyond a distal end of the outer conductor.

5. A sterilisation device according to claim 1, wherein the first electrode comprises a conductive end cap mounted beyond a distal end of the second electrode, the conductive end cap being configured to deflect the plasma transversely into the water mist fluid flow path.

6. A sterilisation device according to claim 1, wherein the water mist fluid flow path tapers towards the outlet.

7. A sterilisation device according to claim 1, wherein the energy delivery tip further comprises an insulating cap mounted at a distal end of the coaxial transmission line to isolate the coaxial transmission line from the internal volume, and wherein the gas conduit includes a fluid pathway formed between the insulating cap and the second electrode.

8. A sterilisation device according to claim 7, wherein the insulating cap is mounted within the second electrode, and wherein the fluid pathway comprises a plurality of openings in the second electrode that permit gas flow around the insulating cap.

9. A sterilisation device according to claim 8, wherein the second electrode is a cylinder, and the plurality of openings each comprise a notch in the cylinder.

10. A sterilisation device according to claim 9, wherein a proximal end of the second electrode is castellated to provide the plurality of openings.

11. A sterilisation device according to claim 1, wherein the energy delivery tip comprises an insulating dielectric material located between the first electrode and the second electrode in the internal volume.

12. A sterilisation device according to claim 11, wherein the dielectric material is quartz.

13. A sterilisation device according to claim 1, wherein the housing is configured as a handheld unit.

14. A sterilisation apparatus comprising: a sterilisation device according to claim 1; a mist generator; a gas supply; and a generator for supplying radiofrequency (RF) or microwave frequency electromagnetic energy to the sterilisation device.

15. A sterilisation apparatus according to claim 14, wherein the mist generator comprises either: an ultrasonic transducer, or a heating element.

16. A sterilisation apparatus according to claim 14, wherein the gas supply is a supply of argon gas.

17. A sterilisation apparatus according to claim 14, wherein the generator is powered by a battery.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Features of the invention are now explained in the detailed description of examples of the invention given below with reference to the accompanying drawings, in which:

[0040] FIG. 1 is a schematic diagram of a sterilisation apparatus according to an embodiment of the present invention;

[0041] FIG. 2 is a diagram of an applicator;

[0042] FIG. 3 is a cross-sectional view of the applicator shown in FIG. 2; and

[0043] FIG. 4 is a cross-sectional view of a second applicator.

DETAILED DESCRIPTION; FURTHER OPTIONS AND PREFERENCES

[0044] This invention relates to a device for performing sterilisation using hydroxyl radicals that are generated by creating a plasma in the presence of water mist.

[0045] FIG. 1 is a schematic diagram of a sterilisation apparatus 100 which is an embodiment of the present invention. The apparatus 100 is capable of generating hydroxyl (OH) radicals in order to sterilise a surface or an area. For example, the apparatus 100 may be used to sterilise medical apparatuses or hospital bed spaces. The apparatus 100 comprises a generator 102 which able to controllably deliver radiofrequency (RF) and/or microwave energy to an applicator 104. The generator may be of type disclosed in WO 2012/076844, for example. The generator 102 is connected to the applicator 104 by a coaxial cable 106. The coaxial cable 106 comprises an inner conductor, an outer conductor and a dielectric material separating the inner conductor from the outer conductor. The coaxial cable 106 may couple energy into the applicator 104 through a QMA connector or the like. In some examples, the generator 102 may be arranged to monitor reflected signals (i.e. reflected power) received back from the applicator 104 in order to determine an appropriate signal to be conveyed to the applicator 104. The radiofrequency and/or microwave energy is utilised at the applicator 104 in order to strike and sustain a thermal or non-thermal plasma in order to generate hydroxyl radicals in a manner which is explained in more detail below. In some examples, the thermal or non-thermal plasma may be used directly to sterilise surfaces.

[0046] The apparatus 100 further comprises a mist generator 108, which is arranged to deliver water mist (e.g. moisture or fog) to the applicator 104. The mist generator 108 may generate a mist by means of an ultrasonic transducer, for example. Alternatively, the mist generator 108 may be arranged to heat water to generate steam or mist to be passed to the applicator 104. The mist is supplied to the applicator 104 in order to generate hydroxyl radicals by a process which will be explained in more detail below. By using mist generator 108 in this way the apparatus 100 can be used to sterilise surfaces or objects without the use of any cleaning chemicals, reducing costs associated with sterilisation and allowing sterilisation to be performed when cleaning chemicals are in short supply. The use of hydroxyl radicals for sterilisation also ensures that there are no harmful by-products.

[0047] The mist generator 108 may include a pump or other fluid driving unit to cause generated mist to flow towards the applicator 104.

[0048] A gas supply 110 is connected to the applicator 104 to supply gas for forming a plasma which is used to generate hydroxyl radicals in a manner which will be explained below. The gas supply 110 may be a supply of any suitably inert gas for formation of a non-thermal or thermal plasma, for example argon, helium, nitrogen, carbon dioxide or a combination thereof. The gas supply 110 may be configured to allow adjustment of the flow rate of gas which is delivered to the applicator 104. The gas supply can supply between 1.5 and 10 litres of gas per minute, for example.

[0049] It may not be essential to provide an independent driving unit for mist flow. Instead, the mist may naturally diffuse towards the applicator. The mist may be entrained by a flow of gas, which in turn will accelerate the diffusion rate of the mist.

[0050] The flow rate of gas may be in the range 1.5 to 15 litres/minute, preferably between 2 and 6 litres/minute. The mist generator 108 may be arranged to generate sufficient mist for the mist to form at least 2% by volume of the combined gas/mist stream. The flow rate of the gas may be controlled to reach a desired proportion of gas and mist in the combined stream.

[0051] In some embodiments of the invention it is envisaged that the generator 102, the mist generator 108 and the gas supply 110 may each be portable, and the applicator 104 may be a handheld applicator such that the present invention provides an effective sterilisation apparatus which is easily transportable by a user.

[0052] The applicator 104 is shown in more detail in FIGS. 2 to 4 below. To sterilise a surface, a plasma is created in the applicator 104 by applying energy from the generator 102 to the gas delivered from the gas supply 110. For example, RF energy may be used to strike a plasma and microwave energy may be used to sustain the plasma. For example, plasma may be generated as disclosed in WO 2009/060213. Simultaneous with the generation of plasma, water mist from the mist generator 108 is passed through a housing of the applicator 104 along a fluid flow path which passes through the plasma in order to produce a spray 112 of hydroxyl radicals which pass out of the applicator 104 to be directed at a surface or into an area for sterilisation. Examples of hydroxyl radical generation in this manner are disclosed in WO 2009/060214, for example.

[0053] FIG. 2 shows a schematic view of a first applicator 200 which may be used in an embodiment of the present invention. In particular, FIG. 2 shows detail regarding an energy delivery tip of the applicator 200. A cross-sectional view showing the applicator more generally is shown in FIG. 3.

[0054] The applicator 200 may be produced at any suitable scale. For example, the applicator may be sized to be gripped by a human hand. Alternatively, a larger version suitable for mounted on a stand may be manufactured. In use, the stream of plasma and/or OH radicals emitted by the applicator may be directed into a volume to be sterilized, e.g. the inside of a vehicle (e.g. ambulance) or a hospital bed or surgical suite.

[0055] The applicator 200 comprises a generally elongate housing 202, which contains components required to generate hydroxyl radicals which are directed out of a distal outlet 204 towards a surface or object to be sterilised. In particularly preferred embodiments the applicator 200 may be handheld by a user to manually pass the applicator 200 over the surface or object.

[0056] Within the housing 202, the applicator 200 comprises an energy delivery structure that comprises a coaxial transmission line 206 that has an energy delivery tip 205 at a distal end thereof. A proximal end of coaxial transmission line 206 terminates in a QMA connector 207 or the like provided such that RF and/or microwave energy may be introduced to the energy delivery structure from a generator, e.g. via a cable as discussed above in relation to FIG. 1.

[0057] The coaxial transmission line 206 comprises an inner conductor 208, an outer conductor 210 and a dielectric material 212 separating the inner conductor 208 and the outer conductor 210. The coaxial transmission line 206 lies along a longitudinal axis of the housing 202.

[0058] The energy delivery tip 205 comprises a first electrode 214 electrically connected to the inner conductor 208, a second electrode 216 electrically connected to the outer conductor 210, and a conductive end cap 218, which is spaced away from the distal end of the second electrode 216 to define a gap 220. In this embodiment, the second electrode 216 is provided as a hollow cylinder which is open at each end, and the first electrode 214 is positioned generally along the longitudinal axis of the second electrode 216. An annular space is thereby defined between the first electrode 214 and the second electrode 216.

[0059] The first electrode 214 may be formed by an extension of the inner conductor 208 of the coaxial transmission line 206. The first electrode 214 is preferably straight, though in some examples the first electrode 214 may be provided in other shapes. For example, the first electrode 214 may be a helical electrode.

[0060] The conductive end cap 218 is a disc of conductive material (e.g. copper, silver, gold or plated steel) that is electrically connected to the first electrode 214 and shaped to lie over the mouth of the opening to the second electrode 216. The conductive end cap 218 is displaced from the distal end of the second electrode 216 in the longitudinal direction to form the gap 220. The gap 220 is smaller than the radial separation of the first electrode 214 and second electrode 216, i.e. the radial distance between the outer surface of the first electrode 214 and the inner surface of the hollow cylinder that forms the second electrode 216. For example, the gap 220 between the end cap 218 and the second electrode 216 may have a length in the longitudinal direction of around 0.5 mm.

[0061] The first electrode 214, second electrode 216 and conductive end cap 218 are configured such that, when energy (e.g. an RF signal) is supplied to the coaxial transmission line 206, a high voltage condition is set up in and around the gap 220. The input signal may be control to cause the voltage to be high enough at the gap 220 to strike a plasma in gas flowing through or past an outer surface of the probe tip 205.

[0062] The effect of the geometry of the end cap 218 is to create a plasma generation region within the probe tip 205 at its distal end. Thermal or non-thermal plasma may be struck and sustain in this region through suitable delivery of RF and microwave energy through the coaxial transmission line 206 as is known.

[0063] As discussed below, in this embodiment the gas from which the plasma is formed is supplied to the annular space formed between the first electrode 214 and the second electrode 216. The gas flows through the probe tip 205 in the longitudinal direction. At the plasma generation region, the gas or plasma is diverted by the end cap 218 in a radial direction to intersect with a flow path 226 of water mist, as described below.

[0064] Within the second electrode 216, positioned at the distal end of the coaxial transmission line 206, is a generally cylindrical ceramic cap 222, which may extend for around 2 mm in the distal direction beyond the end of the dielectric material 212. In some embodiments, the first electrode 214 may be connected to the inner conductor 208 of the coaxial transmission line 206 by a conductive element which extends through the ceramic cap 222.

[0065] A gas conduit 224 is formed around the coaxial transmission line 206 in order to deliver gas to the energy delivery tip. At a proximal end of the applicator 200 the gas conduit 224 comprises a connector 225 to receive gas from the gas supply 110. Gas is able to flow from the gas conduit 224 to within the second electrode 216 through castellations or apertures 217 which are formed in the proximal end of the second electrode 216. It may be desirable to have a plurality of castellations or apertures spaced regularly around the circumference of the second electrode 216 so that the flow of gas into the energy delivery tip if substantially uniform around the longitudinal axis.

[0066] Around the gas conduit 224, a fluid flow path 226 is formed in the applicator housing 202 to direct water mist from an inlet 227 to the outlet 204. As shown in FIG. 2, the fluid flow path 226 generally tapers in a distal direction towards the outlet 204. This serves the dual function of bringing the water mist into contact with the plasma being emitted from the gap 220 and to increase the flow rate of the mist. The plasma causes generation of hydroxyl radicals in the water mist, which are then ejected through the outlet 204 as a directable flow or spray.

[0067] In use, the gas supply 110 is operated to pass gas into the applicator 200 and through the gas conduit 224. The ceramic cap 222 has a chamfered distal face to encourage gas flowing from the gas conduit 224 into the second electrode 216 to pass between the first electrode 214 and the second electrode 216, where a thermal or non-thermal plasma is struck. For example, a plasma may be struck using RF energy, and sustained using microwave energy. Of course, it is envisaged that in some embodiments either RF or microwave energy may be used to strike and sustain the plasma. The power supplied to sustain the plasma may be controlled to maintain the plasma in a preferred state, e.g. as a non-thermal plasma.

[0068] At the same time as the plasma is produced, the mist generator 108 passes gas into the applicator 200 to provide a flow of water mist along the fluid flow path 226. The plasma passes out of the second electrode 216 through the gap 220, which forms a circumferential outlet for directing plasma into the fluid flow path 226 of water mist passing through the applicator 200. The plasma is shown in FIG. 3 by arrows 229. As the water mist passes through the plasma, the water molecules are ionised to produce hydroxyl radicals which pass through the outlet 204 and towards a surface or object to be sterilised.

[0069] FIG. 4 shows a cross-sectional view of a second applicator 300 which may be used in an embodiment of the invention. In particular, the applicator 300 is adapted such that it may be used to sterilise surfaces or objects using hydroxyl radicals or using a thermal or non-thermal plasma which is emitted from the applicator 300. Features of the second applicator 300 which correspond with the first applicator 200 have been given the same reference numerals, and are not described again.

[0070] The applicator 300 comprises an energy delivery tip 305 connected to the distal end of a coaxial transmission line 206. The energy delivery tip 305 is configured to produce a thermal or non-thermal plasma which passes through the outlet 204 of the applicator 300. In this way, the applicator 300 may be used for sterilisation using just plasma when a gas supply, such as gas supply 110, is activated, or may be operable to produce hydroxyl radicals when the gas supply and a mist generator, such as mist generator 108, are both activated.

[0071] The energy delivery tip 305 comprises a first electrode 302 connected to the inner conductor 208 of the coaxial transmission line 206. In some embodiments, the first electrode 302 may be a continuation of the inner conductor 208. A second electrode 304 is connected to the outer conductor 210 of the coaxial transmission line 206. In this embodiment, the second electrode 304 is provided as a hollow cylinder which is open at each end, and the first electrode 302 is positioned generally along the longitudinal axis of the second electrode 304. In the embodiment shown, the first electrode 302 has a length of 20 mm, and the distal end of the first electrode 302 is 2 mm from the distal end of the second electrode 304. The spacing between the first electrode 302 and the second electrode 304 in the radial direction is approximately 1.3 mm. The first electrode 302 and the second electrode 304 are arranged to define an annular region 308 therebetween for receiving gas from a gas inlet 310, wherein a gas conduit is formed from the gas inlet, through the second electrode 304 and into the annular region 308 between the first electrode 302 and the second electrode 304.

[0072] At a distal end of the energy delivery tip 305 a quartz tube 312 is positioned within the annular region 308, with a gap between the quartz tube 312 and the first electrode 302 through which gas is able to flow. For example, the quartz tube 312 may have a length of 12.35 mm, and may be positioned such that the distal end of the quartz tube 312 is coterminous with the distal end of the second electrode 304. By positioning the quartz tube 312 in this way, the electric field in the gas-filled gap between the first electrode 302 and the second electrode 304 is increased to facilitate a plasma strike. The region within the quartz tube 312 is thus a plasma generation region.

[0073] At a proximal end of the energy delivery tip, an insulating element is provided to separate the coaxial transmission line 206 and the plasma generation region. The insulating element in this example comprises a ceramic cap 314 which sits around a proximal region of the first electrode 302. There is a gap between the cap 314 and the second electrode 304 in order to provide a conduit for gas to flow into the energy delivery tip from the inlet 310. For example, the cap 314 may have a length of 8 mm and an outer diameter of approximately 4.3 mm. The cap 314 is provide to prevent striking of the plasma at the proximal end of the energy delivery tip. In some examples the distal end of the cap 314 may be chamfered to encourage gas to flow between the quartz tube 312 and the first electrode 302, where the plasma is struck.

[0074] A distal end of the second electrode 304 is open to form an outlet for plasma generated within the energy delivery tip. In this way, plasma is directed in a longitudinal direction out of the energy delivery tip and towards the outlet 204 of the applicator 300. This is shown in FIG. 4 as a plume 316 of plasma which projects outwardly from the outlet 204 where it may be directed onto a surface or an object by a user for sterilisation.

[0075] The applicator 300 may be used in either a first mode for sterilisation using hydroxyl radicals, or a second mode for sterilisation using plasma.

[0076] In a first mode, the gas supply 110 is operated to pass gas into the applicator 300 via the inlet 310. The gas passes into the region between the first electrode 302 and the quartz tube 312 where a plasma is struck. For example, a plasma may be struck using RF energy, and sustained using microwave energy. Of course, it is envisaged that in some embodiments either RF or microwave energy may be used to strike and sustain the plasma. At the same time as the plasma is produced, the mist generator 108 passes water mist into the applicator 300 via a mist inlet 318 to provide a flow of water mist along the fluid flow path 226. The plasma passes out of the second electrode 216 in a longitudinal direction, directing plasma into the fluid flow path 226 of water mist passing through the outlet 204. As the water mist passes through the plasma plume 316, the water molecules are ionised to produce hydroxyl radicals which pass through the outlet 204 and towards a surface or object to be sterilised.

[0077] The second mode comprises the same steps as the first mode, but a water mist is not supplied to the applicator 300, such that only a thermal or a non-thermal plasma is produced as plume 316 directed out of the outlet 204. The plume 316 of plasma may be passed directly over surfaces by a user for sterilisation.

[0078] The features disclosed in the foregoing description, or in the following claims, or in the accompanying drawings, expressed in their specific forms or in terms of a means for performing the disclosed function, or a method or process for obtaining the disclosed results, as appropriate, may, separately, or in any combination of such features, be utilised for realising the invention in diverse forms thereof.

[0079] While the invention has been described in conjunction with the exemplary embodiments described above, many equivalent modifications and variations will be apparent to those skilled in the art when given this disclosure. Accordingly, the exemplary embodiments of the invention set forth above are considered to be illustrative and not limiting. Various changes to the described embodiments may be made without departing from the spirit and scope of the invention.

[0080] For the avoidance of any doubt, any theoretical explanations provided herein are provided for the purposes of improving the understanding of a reader. The inventors do not wish to be bound by any of these theoretical explanations.

[0081] Throughout this specification, including the claims which follow, unless the context requires otherwise, the words “have”, “comprise”, and “include”, and variations such as “having”, “comprises”, “comprising”, and “including” will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.

[0082] It must be noted that, as used in the specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Ranges may be expressed herein as from “about” one particular value, and/or to “about” another particular value. When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by the use of the antecedent “about,” it will be understood that the particular value forms another embodiment. The term “about” in relation to a numerical value is optional and means, for example, +/−10%.

[0083] The words “preferred” and “preferably” are used herein refer to embodiments of the invention that may provide certain benefits under some circumstances. It is to be appreciated, however, that other embodiments may also be preferred under the same or different circumstances. The recitation of one or more preferred embodiments therefore does not mean or imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the disclosure, or from the scope of the claims.