MAGNETIC MARKERS FOR SURGICAL GUIDANCE

Abstract

An implantable magnetic marker comprising at least one piece of a large Barkhausen jump material (LBJ) containing at least one loop. The coiled marker is deployed to mark a tissue site in the body for subsequent surgery, and a magnetic detection system with a handheld probe excites the marker above or below the switching field required for bistable switching of the marker causing a harmonic response to be generated in a bistable or sub-bistable mode that allows the marker to be detected and localised.

Claims

1.-17. (canceled)

18. A magnetic marker comprising: an implantable marker comprising a magnetic material that exhibits a large Barkhausen jump (LBJ) in its magnetization curve, wherein the magnetic material defines a loop, the loop being retained in the implantable marker during detection of the marker following implantation.

19. The magnetic marker of claim 18, wherein the loop comprises one or more sections, wherein the one or more sections define a substantially straight side.

20. The magnetic marker of claim 19, wherein the loop defines one or more angles.

21. The magnetic marker of claim 20, wherein the loop is continuous.

22. The magnetic marker of claim 21, wherein the loop defines one or more angles.

23. The magnetic marker of claim 22, wherein the loop defines three or more angles.

24. The magnetic marker of claim 22, wherein the loop defines four or more angles.

25. The magnetic marker of claim 22, wherein the magnetic material is deployable in final implantable form without needing a shape transition.

26. The magnetic marker of claim 21, wherein the loop is formed integrally.

27. The magnetic marker of claim 20, wherein the one or more sections are four sections, wherein each section defines a substantially straight side.

28. The magnetic marker of claim 20, wherein the magnetic material is coated with a coating or provided within a housing, the coating or housing having a relatively low conductivity.

29. The magnetic marker of claim 28 wherein the coating or housing is formed from a material having a resistivity greater than 2×10.sup.−7 Ωm.

30. The magnetic marker of claim 22, wherein a length of the loop is several time.

31. A magnetic marker comprising: an implantable marker comprising a magnetic material, wherein the magnetic material defines a loop, wherein implantable marker is detectable and localizable using a non-invasive handheld probe, wherein the loop comprises one or more sections, wherein the one or more sections define a substantially straight side, wherein the loop defines one or more angles, the loop being retained in the implantable marker during detection of the marker following implantation.

32. The magnetic marker of claim 31, wherein the magnetic material exhibits a large Barkhausen jump (LBJ) in its magnetization curve.

33. The magnetic marker of claim 31, wherein the magnetic material is deployable in final implantable form without needing a shape transition.

34. The magnetic marker of claim 31, wherein the loop is continuous.

35. The magnetic marker of claim 32, wherein the loop is continuous.

36. The magnetic marker of claim 35, wherein the one or more sections are at least two sections, wherein each section defines a substantially straight side.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0053] For a better understanding of the present invention and to show more clearly how it may be carried into effect, reference will now be made by way of example only, to the accompanying drawings, in which:

[0054] FIG. 1A is a schematic diagram of a detection system for use with a marker according to the invention, the detection system forming part of the prior art;

[0055] FIG. 1B illustrates the components of the detection system shown in FIG. 1A in further detail;

[0056] FIG. 2 illustrates use of a detection system to locate an implanted marker;

[0057] FIGS. 3A and 3B illustrate a third harmonic (H3) response (arbitrary units) from an LBJ wire as the magnitude of the 100 Hz excitation field is increased, shown with both log-log and log-linear scales respectively;

[0058] FIG. 3C shows the time-domain response in the sub-bistable region at point A in the top graph of FIG. 3A when driven by a sinusoidal wave;

[0059] FIG. 3D shows the time-domain response in the bistable region at point B in the graph of FIG. 3A when driven by a sinusoidal wave;

[0060] FIG. 3E is the Frequency domain response from an LBJ wire in the sub-bistable and bistable switching modes at 100 Hz excitation frequency;

[0061] FIG. 4 is a block diagram of a magnetic detection system for use with a marker of the present invention;

[0062] FIGS. 5A and 5B illustrate a deployment device for deployment of a marker according to the present invention;

[0063] FIGS. 6A to 6D illustrate embodiments of a marker according to the present invention;

[0064] FIGS. 7A to 7C illustrate further embodiments of a marker according to the present invention;

[0065] FIGS. 8A and 8B illustrate alternative embodiments of a marker according to the present invention, the markers each having a variable pitch.

[0066] FIGS. 9A to 9C illustrate yet further embodiments of a marker according to the present invention, wherein the markers have convolutions of varying diameter along the length of the coil;

[0067] FIGS. 10A and 10B illustrate yet still further embodiments of a marker according to the present invention, wherein the markers include multiple intermeshed coils;

[0068] FIGS. 11A and 12A are side views and FIGS. 11B and 12B are end-on views of a marker according to alternative embodiments of the present invention;

[0069] FIG. 13 illustrates yet another embodiment of a marker according to the present invention;

[0070] FIG. 14 illustrates still yet a further embodiment of a marker according to the present invention;

[0071] FIGS. 15A and 15B illustrate another embodiment of a marker according to the invention wherein the magnetic material is part of a stranded wire or braid;

[0072] FIGS. 16A and 16B illustrate yet another embodiment of a marker according to the invention wherein the magnetic material is within a tubular housing;

[0073] FIGS. 17A and 17B illustrate yet still a further embodiment of a marker according to the invention wherein the magnetic material is provided with a coating;

[0074] FIGS. 18A to 18C illustrate examples of possible cross-sections for a marker according to the present invention;

[0075] FIG. 19A illustrates the harmonic response for a marker according to the prior art, with the wire lying along the 0-180° axis in the chart;

[0076] FIG. 19B illustrates the harmonic response from the marker shown in FIG. 6A, with the wire lying along the 0-180° axis in the chart;

[0077] FIG. 19C illustrates the harmonic response from the marker shown in FIG. 6B, with the wire lying along the 0-180° axis in the chart;

[0078] FIG. 19D illustrates the harmonic response from the marker of FIG. 7B, with the wire lying along the 0-180° axis in the chart; and

[0079] FIG. 20 illustrates the marker magnetic H3 response with distance from a probe for the marker of FIG. 7B, wherein each line is one orientation, and orientations of 0, 30, 45, 60 and 90 degrees to the long axis of the marker are shown.

DETAILED DESCRIPTION OF THE INVENTION

[0080] The present invention relates to a magnetic marker that can be implanted for marking a site in the body, for example the site of a lesion and subsequently be detected and localised using a handheld probe. The invention also describes a detection system and method for locating the position of the implanted marker in the body.

[0081] FIGS. 1A and 1B of the accompanying drawings show schematic diagrams of an example of a detection system according to the prior art that may be used to detect a marker according to the present invention. The detection system comprises a probe 2 connected to a base unit 4. The probe has one or more drive coils 8 (see FIG. 1B) that generate an alternating magnetic field to excite a magnetic marker 6. The probe 2 of the

detection system further contains one or more sense coils 10 arranged to detect the changes in the magnetic field caused by the change in magnetisation of the marker.

[0082] FIG. 2 illustrates how the marker 6 may be implanted into a patient's breast and then located using the probe 2.

[0083] It is desirable to provide improved markers for enhanced localisation by the probe. The Applicant's co-pending Application No. GB1801224.5 describes one such marker. The marker comprises at least one piece of magnetic marker material having a large Barkhausen discontinuity in its magnetisation curve, also known as a large Barkhausen jump material (or a LBJ material). When the LBJ material is exposed to an external magnetic field whose field strength opposing the instantaneous magnetic polarization of said length of material exceeds a predetermined threshold value, the switching field H.sub.SW, its magnetic polarization undergoes a rapid reversal. This reversal of magnetisation generates a magnetic pulse with rich harmonic components. Conventionally, the markers are sized to be above the so-called ‘critical length’, that is the length at which the magnetization can undergo the full bistable transition or ‘flipping’ behaviour which is required to generate a significant harmonic response. However, the inventors found that a harmonic response can be obtained from markers significantly below their critical length and/or below the switching field H.sub.SW in a newly recognized “sub-bistable” mode and that this is advantageous for use for localization of the implantable marker.

[0084] FIGS. 3A to 3E illustrate this bistable and so-called “sub-bistable” behaviour of the LBJ material which may be incorporated into an implantable marker. FIGS. 3A and 3B illustrate a third harmonic (H3) response (arbitrary units) from an LBJ wire as the magnitude of the 100 Hz excitation field is increased, shown with both log-log and log-linear scales respectively. As demonstrated, when a piece of cobalt-iron amorphous LBJ microwire above the critical length is excited with an alternating magnetic field at 100 Hz, the third harmonic (H3) response is shown in FIG. 3A. H3 is here taken as representative of the harmonic content of the marker response. Once an H3 response is distinguishable from noise, it increases in an approximately linear relationship with excitation field. This continues until the switching field is reached, at which point the response increases dramatically in magnitude as the bistable switching is initiated (region B in FIG. 3A). It is this point at which LBJ above a critical length is normally identifiable. The log-linear and log-log scales clearly illustrates the change in mode. However, FIG. 3A shows that by using the “sub-bistable” mode (region A in FIG. 3A), the marker can be detected even when the field is almost 2 orders of magnitude lower than the switching field required for bistable behaviour. This means that for a given drive field, the marker can be detected at a much greater distance from the probe.

[0085] FIG. 3C shows the time-domain response in the sub-bistable region when driven by a sinusoidal wave. It is seen as a distorted sine wave, in contrast to the bistable time-domain response which shows the classic short pulses as the magnetisation reverses (see FIG. 3D). In the frequency domain, the rich harmonics of the bistable mode contrast with the less rich harmonic response of the sub-bistable mode (see FIG. 3E). However, such harmonic response is still richer than the response from non-bistable amorphous wires and thus this response may be used to accurately identify a marker even when the length of wire is below the ‘critical length’ and the excitation field is below the ‘switching field’.

[0086] FIG. 4 of the accompanying drawings shows a block diagram of a magnetic detection system which may be used to locate a marker according to the prior art or according to the invention. A frequency generator 12 for example an oscillator or waveform generator (f.sub.D is 100 Hz to 50 kHz) generates a preferably sinusoidal alternating signal which excites one or more drive coils 8. The one or more drive coils generate an alternating magnetic field that extends into the tissue containing a magnetic marker 6 comprising at least one piece of a large Barkhausen jump material (LBJ).

[0087] The alternating magnetic field excites the marker 6 and the magnetisation of the marker leads to the generation of harmonic components in the field. Depending on the arrangement of the marker, the harmonics may be odd harmonics, (3.sup.rd, 5.sup.th, 7.sup.th etc.) or even harmonics (2.sup.nd, 4.sup.th, 6.sup.th etc.) or a combination of both odd and even harmonics. The marker is detected by measuring the magnitude of one or more of the harmonic frequencies directly or by measuring the ratio of the magnitude of one or more harmonics to others or to the magnitude of the fundamental frequency.

[0088] The response from the marker is detected by one of more sense coils 10 to generate a sense voltage or current. The sense coils may be in a handheld or robotic probe. A high-pass or notch filter 14 may be arranged to filter out or attenuate at least components of the sense signal at the drive frequency so that the resulting signal has minimal content at the drive frequency and comprises higher harmonic components of the signal, for example the second, third, fourth, fifth or seventh order harmonics or combinations of these. The filter may take the form of a passive LCR type filter comprising a known arrangement of for example capacitors, inductors and resistors or an active filter comprising a known arrangement for example based on one or more op-amps.

[0089] The filtered signal may be fed to a harmonic detection circuit 16 which amplifies one or more harmonic components of the signal and converts the signal 18 to a measure of distance from the probe to the marker. A user display and sound generator 20 provides a visual and audio output to the user indicating for example, the proximity of the marker or the magnitude of the magnetic signal. The system may indicate the proximity, size, distance to, direction or orientation of the marker, or combinations of these.

[0090] When a straight piece of LBJ wire is excited, the magnetic response it gives is directional, that is there is a greater response along the axis of the wire and a much lower response in a direction perpendicular to the wire. For this reason, the inventors co-pending Application GB1801224.5 describes how the dipole length of the LBJ material in the direction of the drive field is an important parameter for enabling harmonic response and detection and discloses the use of a number of wires, for example in a tripod arrangement, such that the dipole length in any given direction is substantially similar. However, such markers have thin sections making them fragile or vulnerable to movement. This can make satisfactory deployment of the marker difficult.

[0091] FIGS. 5A and 5B show an example of a deployment system according to the prior art that may be used to deliver a marker to a surgical site. FIG. 5A shows a deployment device 200 comprising a needle 202 and a plunger 204. In use, the needle is inserted into the target tissue under imaging guidance. The deployment device is arranged such that on depression of the plunger, the magnetic marker is deployed from the end of the needle into the target tissue. FIG. 5B shows a detail of the distal end of the deployment device 200 containing a magnetic marker 6 in the needle 202 together with a plunger 204.

[0092] It is critical that the marker 6 deploys correctly from the needle because otherwise the similarity or identity of the dipole length in each direction will be affected, leading to a non-uniform and inaccurate response.

[0093] The present invention provides improved markers that contain LBJ material which may be detected using their conventional bistable behaviour or using the recently identified “sub-bistable” mode. The inventors have surprisingly found that markers that have a LBJ material formed into a coil or loop produce a measurable harmonic response. This was not to be expected because classic switching behaviour occurs through a cascade or domino effect in which the magnetic domains in the LBJ wires all flip at one time, and thus alignment of all the domains with the driving magnetic field is key. Domains not substantially aligned with the field will not flip or switch, thus resulting in the use of straight wires for detection. Thus, the skilled person would consider the use of any other configuration to be counter-intuitive based on the prior art literature. The coiled markers according to the invention demonstrate switching response similar qualitatively to the classic bistable switching described in the prior art at higher fields and larger diameter coils, while at lower fields and with smaller diameter coils, the response is ‘sub-bistable’ as described in GB1801224.5.

[0094] Furthermore, while a single straight LBJ wire provides an axial response that is much greater than the transverse (perpendicular to the axis) response, more surprisingly, the inventors have found that a coil of LBJ wire when excited in the sub-bistable mode (and indeed the bistable mode), has a larger transverse response than axial response, even when its length is several times its diameter.

[0095] FIGS. 6A to 6D illustrate different embodiments of a marker 6 according to the invention. Each marker 6 comprises a coil 6a of magnetic material. FIG. 6A shows a simple coil of magnetic marker material. FIG. 6B shows a coil 6a with a further piece of magnetic material, for example in the form of a rod of wire 6b placed axially inside the coil. FIG. 6C shows a coil 6a with one end of the coil folded back into the centre of the coil to form an axial element 6c inside the coil. FIG. 6D shows a further embodiment in which both ends of the coil 6a are folded back through and towards the centre of the coil to form axial elements 6d, 6e inside the coil. These axial elements inside the coil increase the magnitude of the axial magnetic response which can be used to obtain the desired uniformity or asymmetry of response.

[0096] FIGS. 7A to 7C shows coiled markers according to the present invention, with a different pitch of the coil 6a compared to the tight pitch shown in FIGS. 6A to 6D. FIG. 7C shows a coiled marker 6 in which the ends 6f, 6g continue axially outside the coil. The extended ends increase the magnitude of the axial magnetic response which can be used to obtain the desired uniformity or asymmetry of response.

[0097] FIGS. 8A and 8B show embodiments of a coiled marker according to the present invention in which the pitch of the coil varies through its length. FIG. 8A shows a coil with a central region 6h with a smaller pitch and outer regions 6i with a larger pitch. In contrast, FIG. 8B shows a coiled marker having a central region 6j with a larger pitch and outer regions 6k with a smaller pitch. It is to be appreciated that the pitch can be varied in any way along the length of the marker in discrete or continuous ways within the scope of the invention. As can be seen from the values in Table 1 below, an increase in the pitch causes the magnitude of the axial magnetic response to increase relative to the transverse response. This can also be used to obtain the desired uniformity or asymmetry of response.

[0098] FIGS. 9A to 9C illustrate alternative embodiments of a marker according to the invention wherein the diameter of the marker varies along the length of the marker. For example, FIG. 9A reduces the diameter of the convolutions of the coil from one end of the coil to another to form a conical shaped marker. FIG. 9B reduces the diameter of the convolutions of the coil from both ends of the coil towards the centre to form a hourglass shaped marker. FIG. 9C increases the diameter of the convolutions of the coil from both ends of the coil towards the centre to form a barrel shaped marker. Varying the diameter of the convolutions of the coiled marker along its length is advantageous to modify the magnetic response from different directions. Coiled makers having both different diameters and pitches fall within the scope of the invention. Increasing the number of coils and their diameter increases the magnitude of the response in a cumulative fashion, although there are some losses due to the proximity of the coils to each other. Thus these arrangements could be used to modify the uniformity of the magnetic response as desired.

[0099] Further embodiments of a marker according to the present invention are shown in FIGS. 10A and 10B, wherein the marker is provided with multiple coils combined or intermeshed within the marker. FIG. 10a illustrates a marker with two coils 6l, 6m and FIG. 10B shows a marker with three coils 6n, 6o, 6p. Each of the coils that are combined could have a different diameter and/or pitch within the scope of the invention. However, it is preferable for the multiple coils to have similar diameters and pitches such that they can mesh closely together as shown in FIGS. 10A and 10B to maximise the efficient use of space within the marker envelope. Additional coils increase the magnitude of the response in an approximately additive fashion, although there are some losses due to the proximity of the coils to each other.

[0100] FIGS. 11A to 13 illustrate further embodiments of the marker in which additional features are present to aid engagement with tissue once the marker has been implanted into a patient. Examples include a hook or prong or conical coil shapes, and be at one or both ends of the marker, or protrude from the side of the marker. For example, FIGS. 11A and 11B show a coiled marker wherein the ends of the coil extend away from the coil 6 to provide engagement members 6q. FIGS. 12A to 12B has these ends shaped to form a hook-like engagement feature 6r. The features may be formed from the same material as the coil or from a different material. The features may further be arranged to compress within the marker deployment device and then, resiliently or via a shape memory change, transform into their final shape upon deployment. Such features may be adapted to aid engagement with a particular kind of tissue. For example a larger diameter coil or conical coil shape, such as that shown in FIG. 13, may be beneficial for locating in a lumen, blood vessel, or airway in the lung. Barb shaped features may be beneficial for locating in breast tissue or a biopsy cavity.

[0101] FIG. 14 shows yet another embodiment of a marker according to the invention in which a smaller coil 6s is combined with a larger outer diameter coil 6t within the marker. This is advantageous in order to provide more magnetic material within the same space envelope defined by a narrow gauge delivery needle. Again, the coils could be different diameters and pitches within the scope of the invention but preferably are closely wound with minimal space between each turn in the coil in order to maximise the efficient use of space within the marker envelope.

[0102] The LBJ magnetic material that is wound into coil as herein described may be combined with other materials to improve the marker. For example, the marker may be packaged within other materials. In this respect, markers for implantation need to be both biocompatible to prevent a reaction with body tissue, and robust. Some preferred magnetic materials are thin (wires below 0.15 mm in diameter), and contain non-biocompatible materials. Therefore, to improve the biocompatibility and robustness of the marker, it is preferable to provide a housing or coating for the magnetic material. FIGS. 15A to 18B of the accompanying drawings illustrate alternative combinations of the magnetic material with other materials to form the packaged marker. This may be in the form of a coating 22, as shown in FIGS. 17A to 17B. For example, the magnetic wire may be coated with a polymer coating such as FEP, Parylene, PTFE, ETFE, PE, PET, PVC or silicone, or an epoxy-based encapsulant. Alternatively or additionally, the magnetic material may be encased in a tube 24 prior to being formed into the required marker shape, as shown in FIGS. 16A and 16B (shown in the pre-formed condition). This arrangement improves the robustness of the magnetic material. Suitable materials for the tube include Nitinol, titanium, stainless steels and other biocompatible alloys. Preferably the material is non-magnetic and has a relatively low conductivity, in order not to influence the magnetic response of the marker. Preferably the volume resistivity is greater than 2×10.sup.−7 Ωm (Ohm-metres) in order to minimise the production of Eddy currents within the housing which could affect the magnetic response.

[0103] In a preferred embodiment a biocompatible and insulating coating or sheath such as FEP, Parylene, PTFE, ETFE, PE, PET, PVC or silicone further surrounds the tube 24. This insulating layer stops conduction between the turns within the coils further reducing the effects of Eddy current on the magnetic response of the marker.

[0104] Table 2 below shows the influence of the conductivity of the tube material on the harmonic response for straight lengths of an LJB wire in different tube materials. The signal from the LBJ wire in the copper tube with a material resistivity of 0.17×10.sup.−7 Ωm is at least 16 times lower than the signal from similar wires in tubes made with other materials with a higher resistivity of greater than 2×10.sup.−7 Ωm. The use of selective cutting of the tube such as with an interrupted laser cut spiral, which also supplies flexibility for coiling, may also be used to increase resistance and reduce the production of Eddy currents. The polymer coating may be applied before or after the material or tube is formed into a coil.

[0105] In a preferred embodiment, the marker housing could be formed from a moulded or extruded material. For example, a polymer may be extruded around the magnetic wire to form a coated wire that can then be formed into a loop or coil. Any of the embodiments above could also be overmoulded with a polymer to form a marker. The advantage of such an embodiment is that the polymer could provide biocompatibility and also make the manufacturing process simpler and less costly. The use of polymers also minimises any Eddy current effects seen with metal coatings or housings that could affect the magnetic response. Suitable materials for the coating or overmoulding include PEEK, PEKK, polyethylene, polypropylene, polyester, polyurethane, polyimide, polyether block amide, polyamide, PTFE, FEP, PET and silicones.

[0106] In another preferred embodiment, a marker according to the present invention includes a housing comprising one or more strands of material 26 which are wound around the magnetic material to form a more robust construction prior to forming into the final marker shape. FIGS. 15A and 15B show, for example, a piece of marker material 6 with 6 strands of a different material 26a-f wound around it in a helical arrangement (see FIG. 15B). The surrounding material could be in the form of wires with round, rectangular or other cross section. Preferably the surrounding material completely encloses the magnetic marker material. The strands of the surrounding material could be formed from one material or from more than one type of material to obtain a different profile of material properties such as strength, stiffness, resistivity, magnetic response, radiopacity or echogenicity. The surrounding material could be wound in a single layer or in multiple layers within the scope of the invention. Similarly, the layers could be wound in alternate senses or directions, and could comprise different materials or cross sections. Suitable materials for the surrounding material include those listed above for the tube embodiment of FIGS. 16A and 16B. Various braids or weaves including the magnetic material in wire form could also be envisaged within the scope of the invention.

[0107] In any of the above embodiments, the marker may comprise a resiliently deformable member (tube, wire strands or coating) containing the LBJ wire such that the coil expands on deployment to a larger size. The expansion may be driven elastically by a resiliently deformable material or by a shape memory transition material such as nitinol.

[0108] In a further embodiment, the cross section of the marker may take a number of forms including round, rectangular or triangular, as shown in FIGS. 18A to 18C respectively. In certain instances, a marker having a section in which there is a substantially straight side (such as in FIGS. 18B and 18C) may be advantageous in order to provide angles at which there is an increased magnetic response relative to other angles, e.g. when a straight section is aligned with the excitation field.

[0109] Table 1 below illustrates characteristics of markers according to the invention and their H3 magnetic response. Embodiments shown in FIGS. 6 to 10 of the drawings are identified in column 1.

TABLE-US-00001 TABLE 1 Ratio max:min Diameter Length Number of Pitch Aspect ratio H3 magnetic Dominant Housing Marker (mm) (mm) Turms (mm) (length:diameter) response Direction Material Prior Art straight 0.1 4 none N/A 40.0 39.1 Axial None length of wire Single Coil 1.26 7 22 0.32 5.6 19.8 Perp. Cu Single Coil 1.26 7 11 0.64 5.6 6.6 Perp. Cu Single Coil 1.26 7 8 0.88 5.6 5.5 Perp. Cu Single Coil 1.26 7 4.5 1.56 5.6 1.4 None Cu Single Coil 1.06 8 1.5 5.3 7.5 4.7 Axial Cu Single Coil 1.16 6 2 3.0 5.2 1.6 None Cu Single Coil (FIG. 6A) 1.03 6 17 0.35 5.8 10.9 Perp. Cu Coil & Axial wire (FIG. 6B) Coil: 1.03 6 17 0.35 5.8 1.2 None Cu Axial wire: 0.1 3.2 none N/A None Single Coil (FIG. 7B) 1.01 7 8.5 0.82 5.6 1.2 None Ti Variable Pitch 1.01 8 1 2.5 7.9 2.2 Perp. Cu Coil 9 0.33 (FIG. 8A) 1 2.5 Mullti-coil, 3 coils 1.06 7 3 × 3 2.33 6.6 1.6 None Cu (FIG. 10B)

[0110] Table 2 below illustrates the effect of the housing material of the marker on the magnitude of H3 response at a distance of 20 mm for a probe of a straight length of Co—Fe LBJ material of 4 mm.

TABLE-US-00002 TABLE 2 Housing Hosing Housing Housing Material H3 response relative Ratio max:min H3 Material Diameter (mm) Length (mm) Resistivity (Ωm) to copper magnetic response Copper 0.29 4 1.7 × 10.sup.−8 1 3 316 Stainless Steel 0.50 4 7.4 × 10.sup.−7 16 23 Titanium 0.51 4 5.2 × 10.sup.−7 17 26 Nitinol 0.33 4 7.6 × 10.sup.−7 19 41

[0111] Table 3 below shows how the magnitude of H3 response varies with diameter at a distance of 20 mm for a marker with similar coil pitches for coils in both 304ss and PET as well as demonstrating the increased response from coils in a material where there is less opposing eddy currents e.g. coils (PET), showing the increase in relative response per turn for the single coils with diameter. It also demonstrates the increased signal from a coil of smaller diameter inside a coil of larger diameter (FIG. 14). All coils are measured in a perpendicular orientation.

TABLE-US-00003 TABLE 3 Signal per Turn/ H3 response Magnetic Coil 304ss relative Coil Material Length No of Pitch Ø0.88 mm ø0.88 mm 304ss Coil Material Diameter (mm) (mm) Turns (mm) Signal per turn coil Single Coil A 304ss 0.88 5 13 0.39 1 1 Single Coil E 304ss 0.99 7 17 0.41 1.8 2.3 Single Coil B 304ss 1.10 5 14 0.36 2.9 3.1 Single Coil C 304ss 1.25 5 14 0.36 3.3 3.5 Single Coil D 304ss 2.02 5 11.5 0.43 6.2 5.5 Coil C inside 304ss 1.25 inside 2.02 5 14 inside 11.5 0.36 inside 0.43 N/A 6.7 Coil D (9) Single Coil F PET 1.1 8 15 0.53 3.9 4.5 Single Coil G PET 1.2 6 10 0.60 4.6 3.5 Single Coil H PET 1.46 5.8 10 0.58 5.9 4.5 Single Coil I PET 2.22 5.4 10 0.54 7.7 5.9 Single Coil J PET 3.26 5.8 10 0.58 10.1 7.8

[0112] FIGS. 19A to 19D show how the response of various markers varies with the orientation of the marker axis relative to the detection probe, when the marker is excited with the probe arrangement of FIG. 1. In each case the long axis of the marker is aligned with the 0-180° axis in the figure.

[0113] FIG. 19A shows the magnetic response from a prior art single cobalt-iron amorphous LBJ microwire. The harmonic (e.g. H3) response is stronger by a factor of almost 40 times in the axial direction versus the transverse direction of sensing. This asymmetry

of response would be expected from a straight length of LBJ wire based on the prior art literature, for example von Gutfeld (von Gutfeld, R J et al., Amorphous magnetic wires for medical locator applications, Appl. Phys. Lett., Vol. 81, No. 10, 2 Sep. 2002) which describes an axial response many times stronger than the transverse response.

[0114] FIG. 19B shows the magnetic response from the marker of FIG. 6A constructed with a cobalt-iron amorphous LBJ microwire wherein the LBJ wire is in the form of a coil. According to the conventional theory, LBJ wires need to be straight to produce a harmonic response. However, surprisingly, for a piece of LBJ wire, the coil produces a strong harmonic response. More surprisingly, the transverse harmonic response is stronger than the axial harmonic response which is contrary to what would be expected from the physical aspect ratio (length:diameter) which in this case is approximately 6 (see Table 1).

[0115] The inventors have found that such markers can be combined to create a marker with a more optimal or preferred harmonic response profile. Specifically, it is preferable if the harmonic response at a given distance from the marker is substantially uniform.

[0116] Thus for example, the prior art single straight wire can be combined with the coil of FIG. 6A, to obtain the marker of FIG. 6B.

[0117] FIG. 19C shows the variation in the harmonic (H3) response from such a marker of FIG. 6B, constructed with a cobalt-iron amorphous LBJ microwire, as its orientation with respect to the probe is varied. The marker comprises a coil of fine copper tube containing cobalt-iron amorphous LBJ microwire as the magnetic material, the tube being wound into a coil with a further length of the same LBJ wire positioned axially inside the coil. The coil is 1.03 mm in diameter, 6 mm long and has 17 turns, giving a pitch of 0.35 mm. The axial wire is 3.2 mm long.

[0118] It is demonstrated in FIG. 19C that the harmonic magnetic response is substantially uniform regardless of the direction of detection, and specifically, the H3 response in the axial direction is similar to that in the transverse direction. Thus by appropriate choice

of coil parameters and choice of additional axial components, the uniformity of the harmonic response can be adjusted and optimised to obtain the profile of response versus direction that is desired. This could be increased transverse response or axial response, but is most preferably a uniform or equal response regardless of the direction of excitation or sensing. The advantage of a uniform response is that the signal can be reliably and consistently converted into a distance measurement from the probe to the marker. If the uniformity is poor, the user will obtain a different distance measurement depending on the orientation of the marker with respect to the probe which would be confusing. The uniformity of response can be estimated by measuring the variation of response with orientation of the marker relative to the probe, and calculating the ratio of the maximum to minimum response.

[0119] In the context of this disclosure, a uniform response means that the ratio of the maximum to minimum magnitude of the response being measured (be it H3, or other magnetic response) is less than 3 and preferably less than 2. Because the magnetic response when being detected with an arrangement similar to that in FIG. 1 drops off with between the third and fifth power of distance, if the ratio of maximum to minimum magnetic response is less than 2, then the variation in measured distance as the orientation of the marker changes will be within a small range, typically less than ±1-2 mm.

[0120] FIG. 20 shows plots of H3 magnetic response versus distance (using the configuration of FIG. 1) for the marker of FIG. 7B for a number of orientations of the marker. This illustrates how the accuracy of the distance determination can be maintained within ±1-2 mm regardless of orientation of the marker relative to the probe. Table 1 above shows the max:min ratio of H3 response for a range of markers of different constructions.

[0121] The uniformity of response can also be varied by adjusting the pitch, number of turns/convolutions, length, diameter, shape, cross section and end configuration of the coil, and by varying the diameter or pitch of the turns at different points along the length of the coil.

[0122] FIG. 19D shows the response from the embodiment of FIG. 7B which has an increased pitch. The marker comprises a coil of cobalt-iron amorphous LBJ microwire with length 7 mm, diameter 1.01 mm, and 8.5 turns giving a pitch of 0.82 mm.

[0123] By increasing the pitch compared with the marker of FIG. 6A, the axial harmonic (H3) response can be increased with respect to the transverse harmonic to make the response substantially uniform, regardless of the direction of sensing. In this case the max:min ratio of the H3 response is 1.2.

[0124] If the pitch is increased to improve the uniformity of the response, the length of the marker for a given magnitude of response will increase, or the number of convolutions in a given length of marker will be reduced. The inventors have found that in this case, more than one coil can be combined in the form of a multi-start helix to increase the response while maintaining the small size of the marker. FIGS. 10A and 10B show two such examples, one with 2 and one with 3 coils respectively, combined within the marker. In these examples the pitches of the combined coils are the same, but it is to be appreciated that the pitch of the combined coils could be varied to obtain the desired profile of response.

[0125] The present invention provides a new and improved magnetic marker that may be used in a system and method for detecting the marker, thereby enabling a lesion for surgical excision to be located. The marker contains at least a piece of LBJ magnetic material that is wound into a coil having at least one, preferably more, convolutions. The marker may be excited at the switching field (bistable mode) or at a field lower than the bistable switching field (sub-bistable mode) and the generated harmonics measured from any direction to determine the position and orientation of the marker. In embodiments, the marker may also be provided below the critical length of the LBJ material required to enable bistable switching behaviour.