METHOD FOR TREATING A TUBERCULOUS PROSTATITIS SIDE EFFECT CAUSED BY BCG PERFUSION THERAPY FOR BLADDER CANCER

Abstract

A method for treating a side effect caused by bacillus Calmette-Guérin (BCG) perfusion therapy for bladder cancer includes: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture comprising Rhizoma anemarrhenae, Cortex phellodendri, Glycyrrhiza uralensis, Rehmanniae Radix, Fructus corni, Rhizoma dioscoreae, Poria, Moutan cortex, Rhizoma Alismatis, Radix achyranthis bidentatae, and Atractylodes lancea.

Claims

1. A method for treating a side effect caused by bacillus Calmette-Guérin (BCG) perfusion therapy for bladder cancer, comprising: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture comprising Rhizoma anemarrhenae, Cortex phellodendri, Glycyrrhiza uralensis, Rehmanniae Radix, Fructus corni, Rhizoma dioscoreae, Poria, Moutan cortex, Rhizoma Alismatis, Radix achyranthis bidentatae, and Atractylodes lancea.

2. The method of claim 1, wherein the Chinese medicine composition is prepared by the following steps: providing the first mixture; mixing the first mixture with water to form a second mixture; and heating the second mixture to obtain the Chinses medicine composition.

3. The method of claim 1, wherein the first mixture comprises 2-10 parts by weight of Rhizoma anemarrhenae, 1-5 parts by weight of Cortex phellodendri, 1-5 parts by weight of Glycyrrhiza uralensis, 6-10 parts by weight of Rehmanniae Radix, 2-6 parts by weight of Fructus corni, 2-6 parts by weight of Rhizoma dioscoreae, 2-6 parts by weight of Poria, 2-6 parts by weight of Moutan cortex, 2-10 parts by weight of Rhizoma Alismatis, 2-6 parts by weight of Radix achyranthis bidentatae, and 2-6 parts by weight of Atractylodes lancea.

4. The method of claim 3, wherein the first mixture comprises 3-9 parts by weight of Rhizoma anemarrhenae, 2-4 parts by weight of Cortex phellodendri, 2-4 parts by weight of Glycyrrhiza uralensis, 7-9 parts by weight of Rehmanniae Radix, 3-5 parts by weight of Fructus corni, 3-5 parts by weight of Rhizoma dioscoreae, 3-5 parts by weight of Poria, 3-5 parts by weight of Moutan cortex, 3-9 parts by weight of Rhizoma Alismatis, 3-5 parts by weight of Radix achyranthis bidentatae, and 3-5 parts by weight of Atractylodes lancea.

5. The method of claim 3, wherein the part by weight is 2.5-5 gram per part.

6. The method of claim 1, wherein the first mixture further comprises Scrophulariae radix, Herba artemisiae annuae, and Cortex lycii.

7. The method of claim 6, wherein the first mixture further comprises 2-6 parts by weight of Scrophulariae radix, 1-5 parts by weight of Herba artemisiae annuae, and 2-6 parts by weight of Cortex lycii.

8. The method of claim 7, wherein the first mixture further comprises 3-5 parts by weight of Scrophulariae radix, 2-4 parts by weight of Herba artemisiae annuae, and 3-5 parts by weight of Cortex lycii.

9. The method of claim 1, wherein the first mixture further comprises Raphani semen.

10. The method of claim 9, wherein the first mixture further comprises 2-6 parts by weight of Raphani semen.

11. The method of claim 10, wherein the first mixture further comprises 3-5 parts by weight of Raphani semen.

12. The method of claim 6, wherein the first mixture comprises 6-10 parts by weight of Rhizoma anemarrhenae, 1-5 parts by weight of Cortex phellodendri, 1-5 parts by weight of Glycyrrhiza uralensis, 6-10 parts by weight of Rehmanniae Radix, 2-6 parts by weight of Fructus corni, 2-6 parts by weight of Rhizoma dioscoreae, 2-6 parts by weight of Poria, 2-6 parts by weight of Moutan cortex, 2-6 parts by weight of Rhizoma Alismatis, 2-6 parts by weight of Radix achyranthis bidentatae, 2-6 parts by weight of Atractylodes lancea, 2-6 parts by weight of Scrophulariae radix, 1-5 parts by weight of Herba artemisiae annuae, and 2-6 parts by weight of Cortex lycii.

13. The method of claim 12, wherein the first mixture comprises 7-9 parts by weight of Rhizoma anemarrhenae, 2-4 parts by weight of Cortex phellodendri, 2-4 parts by weight of Glycyrrhiza uralensis, 7-9 parts by 10 weight of Rehmanniae Radix, 3-5 parts by weight of Fructus corni, 3-5 parts by weight of Rhizoma dioscoreae, 3-5 parts by weight of Poria, 3-5 parts by weight of Moutan cortex, 3-5 parts by weight of Rhizoma Alismatis, 3-5 parts by weight of Radix achyranthis bidentatae, 3-5 parts by weight of Atractylodes lancea, 3-5 parts by weight of Scrophulariae radix, 2-4 parts by weight of Herba artemisiae annuae, and 3-5 parts by weight of Cortex lycii.

14. The method of claim 6, wherein the first mixture further comprises Raphani semen.

15. The method of claim 14, wherein the first mixture comprises 6-10 parts by weight of Rhizoma anemarrhenae, 1-5 parts by weight of Cortex phellodendri, 1-5 parts by weight of Glycyrrhiza uralensis, 6-10 parts by weight of Rehmanniae Radix, 2-6 parts by weight of Fructus corni, 2-6 parts by weight of Rhizoma dioscoreae, 2-6 parts by weight of Poria, 2-6 parts by weight of Moutan cortex, 6-10 parts by weight of Rhizoma Alismatis, 2-6 parts by weight of Radix achyranthis bidentatae, 2-6 parts by weight of Atractylodes lancea, 2-6 parts by weight of Scrophulariae radix, 1-5 parts by weight of Herba artemisiae annuae, 2-6 parts by weight of Cortex lycii, and 2-6 parts by weight of Raphani semen.

16. The method of claim 15, wherein the first mixture comprises 7-9 parts by weight of Rhizoma anemarrhenae, 2-4 parts by weight of Cortex phellodendri, 2-4 parts by weight of Glycyrrhiza uralensis, 7-9 parts by weight of Rehmanniae Radix, 3-5 parts by weight of Fructus corni, 3-5 parts by weight of Rhizoma dioscoreae, 3-5 parts by weight of Poria, 3-5 parts by weight of Moutan cortex, 7-9 parts by weight of Rhizoma Alismatis, 3-5 parts by weight of Radix achyranthis bidentatae, 3-5 parts by weight of Atractylodes lancea, 3-5 parts by weight of Scrophulariae radix, 2-4 parts by weight of Herba artemisiae annuae, 3-5 parts by weight of Cortex lycii, and 3-5 parts by weight of Raphani semen.

17. The method of claim 1, wherein the bladder cancer comprises urothelial carcinoma, squamous cell carcinoma, adenocarcinoma, sarcoma, or small cell carcinoma.

18. The method of claim 1, wherein the side effect comprises prostatitis.

19. The method of claim 18, wherein the prostatitis is tuberculous prostatitis.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0023] The following embodiments are meant to explain the implementation of the present invention, they should be construed as descriptive merely, and should not restrict the remaining part of the present invention. The person having ordinary skills in the art can easily understand other advantages and effects of the present invention. The present invention may also be implemented or applied by other different embodiments, and various details in this specification may also be modified and changed according to different viewpoints and applications without departing from the spirit of the invention.

[0024] In addition, ordinal numbers such as “first”, “second” and the like used in the specification and claim for modifying elements of the claim do not mean and represent the claimed elements have any antecedent ordinal number, nor do they represent the order (or order of production) between a claimed element and another claimed element. The ordinal numbers are only used to clearly distinguish certain claimed elements having the same name.

[0025] The preparation of the Chinese medicine composition of the present invention is described below, wherein the materials used in the present invention are commercially available and easily available. In addition, the part by weight by weight is 3.75 gram per part.

Preparation Example 1: Preparation of Chinese Medicine Composition-1

[0026] Provide 4 parts by weight of Rhizoma anemarrhenae, 3 parts by weight of Cortex phellodendri, 3 parts by weight of Glycyrrhiza uralensis, 8 parts by weight of Rehmanniae Radix, 4 parts by weight of Fructus corni, 4 parts by weight of Rhizoma dioscoreae, 4 parts by weight of Poria, 4 parts by weight of Moutan cortex, 4 parts by weight of Rhizoma Alismatis, 4 parts by weight of Radix achyranthis bidentatae, 4 parts by weight of Atractylodes lancea, 4 parts by weight of Scrophulariae radix, 3 parts by weight of Herba artemisiae annuae, and 4 parts by weight of Cortex lycii to form a first mixture-1; mix the first mixture-1 with about 267 parts by weight of water to form a second mixture-1; heat the second mixture-1 for about 1 hour to obtain about 107 parts by weight of a crude extract followed by filtering; and, obtain a Chinese medicine composition-1.

Preparation Example 2: Preparation of Chinese Medicine Composition-2

[0027] Provide 8 parts by weight of Rhizoma anemarrhenae, 3 parts by weight of Cortex phellodendri, 3 parts by weight of Glycyrrhiza uralensis, 8 parts by weight of Rehmanniae Radix, 4 parts by weight of Fructus corni, 4 parts by weight of Rhizoma dioscoreae, 4 parts by weight of Poria, 4 parts by weight of Moutan cortex, 4 parts by weight of Rhizoma Alismatis, 4 parts by weight of Radix achyranthis bidentatae, 4 parts by weight of Atractylodes lancea, 4 parts by weight of Scrophulariae radix, 3 parts by weight of Herba artemisiae annuae, and 4 parts by weight of Cortex lycii to form a first mixture-2; mix the first mixture-2 with about 267 parts by weight of water to form a second mixture-2; heat the second mixture-2 for about 1 hour to obtain about 107 parts by weight of a crude extract followed by filtering; and, obtain a Chinese medicine composition-2.

Preparation Example 3: Preparation of Chinese Medicine Composition-3

[0028] Provide 8 parts by weight of Rhizoma anemarrhenae, 3 parts by weight of Cortex phellodendri, 3 parts by weight of Glycyrrhiza uralensis, 8 parts by weight of Rehmanniae Radix, 4 parts by weight of Fructus corni, 4 parts by weight of Rhizoma dioscoreae, 4 parts by weight of Poria, 4 parts by weight of Moutan cortex, 8 parts by weight of Rhizoma Alismatis, 4 parts by weight of Radix achyranthis bidentatae, 4 parts by weight of Atractylodes lancea, 4 parts by weight of Scrophulariae radix, 3 parts by weight of Herba artemisiae annuae, 4 parts by weight of Cortex lycii and 4 parts by weight of Raphani semen to form a first mixture-3; mix the first mixture-3 with about 267 parts by weight of water to form a second mixture-3; heat the second mixture-3 for about 1 hour to obtain about 107 parts by weight of a crude extract followed by filtering; and, obtain a Chinese medicine composition-3.

Example 1

[0029] Due to urothelial carcinoma, a male patient of Example 1 was performed with tumor curettage and BCG perfusion therapy, and the patient had symptoms including night sweats, hot flashes, and morning lethargy ever since.

[0030] A treatment applied to the patient of Example 1 was described below. From day 1, a daily dose of the Chinese medicine composition-1 was administered to the patient every day, wherein the daily dose of the Chinese medicine composition-1 was divided into aliquots for ter in die administration. During the period of the treatment, a transurethral prostate biopsy was collected from the patient, thereby confirming tuberculous prostatitis. After taking the Chinese medicine composition-1 for three weeks, the symptoms of night sweats and hot flashes were no longer observed, and the side effect induced by the BCG perfusion therapy for urothelial carcinoma was significantly ameliorated. The follow-up showed that there was no recurrence of urothelial carcinoma and tuberculous prostatitis.

Example 2

[0031] Due to bladder cancer, a 33-year-old male patient of Example 2 was performed with tumor curettage and BCG perfusion therapy, and the patient had symptoms including night sweats ever since. In addition, the blood test result of GOT/GPT of the patient was 50/80. Moreover, a transurethral prostate biopsy was collected from the patient, thereby confirming prostatitis.

[0032] A treatment applied to the patient of Example 2 was described below. A daily dose of the Chinese medicine composition-2 was administered to the patient every day, wherein the daily dose of the Chinese medicine composition-2 was divided into aliquots for ter in die administration. After taking the Chinese medicine composition-2 for three weeks, the symptoms of night sweats was no longer observed. After two months, the blood test result of GOT/GPT of the patient was 30/30, and it was back to normal. After follow-up for more than 20 years, no recurrence of bladder cancer or prostatitis was found.

Example 3

[0033] A patient of Example 3 was performed with BCG perfusion therapy after receiving the surgery of bladder cancer. In the early stage, symptoms including night sweats, body fatigue, and evening hot flashes occurred, and tuberculous prostatitis was confirmed by the prostate biopsy in the late stage. In addition, the BCG perfusion therapy was suspended after the rising of GOT/GPT.

[0034] A treatment applied to the patient of Example 3 was described below. After the BCG therapy was suspended, a daily dose of the Chinese medicine composition-3 was administered to the patient every day, wherein the daily dose of the Chinese medicine composition-3 was divided into aliquots for ter in die administration. The Chinese medicine composition-3 was solely used to treat bladder cancer and tuberculous prostatitis in the patient of Example 3 after the suspension of BCG perfusion therapy. Said treatment was performed for four months, and there was no oddness shown in the bladder cancer and prostate tracking.

[0035] Although the present invention has been explained in relation to its preferred embodiment, it is to be understood that many other possible modifications and variations can be made without departing from the spirit and scope of the invention as hereinafter claimed.