Cosmetic or dermatological preparation for prophylaxis and/or treatment of atopic dermatitis

Abstract

Agonists for the TRPM-8 receptor, more particularly one or more substances selected from the group of, for example, linalool, geraniol, hydroxycitronellal, WS-3 (N-ethyl-p-menthane-3-carboxamide), WS-23 (2-isopropyl-N,2,3-trimethylbutyramide), Frescolat MAG (1,4-dioxaspiro[4.5]decane-2-methanol), Frescolat ML (menthyl lactate), Coolact P (5-methyl-2-prop-1-en-2-ylcyclohexan-1-ol) and Cooling Agent 10 (menthoxypropanediol), for use as medicaments to counter atopic dermatitis.

Claims

1. A topical cosmetic or dermatological preparation, wherein the preparation is suitable for the treatment and/or prophylaxis of atopic dermatitis and comprises, based on a total weight of the preparation, from 0.01 to 5.0% by weight of one or more TRPM-8 receptor agonists which comprise (1R,2S,5R)—N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide.

2. The preparation of claim 1, wherein the preparation further comprises one or more 1,2-alkanediols.

3. The preparation of claim 2, wherein the one or more 1,2-alkanediols comprise one or more of 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol.

4. The preparation of claim 2, wherein the one or more 1,2-alkanediols comprise 1,2-decanediol.

5. The preparation of claim 1, wherein the preparation further comprises one or more anti-erythematous and/or anti-inflammatory substances selected from licochalcone A, lignin, chroman, isoflavonoids, pentacyclic triterpenes, hamamelis, chamomile extracts, bisabolol, allantoin, calendula extracts, panthenol.

6. The preparation of claim 1, wherein the preparation further comprises licochalcone A.

7. The preparation of claim 6, wherein the preparation comprises a Glycyrrhiza Inflata Root extract that contains licochalcone A.

8. The preparation of claim 1, wherein the preparation comprises, based on a total weight of the preparation, from 0.02 to 5.0% by weight of one or more polyols selected from 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, and from 0.01 to 5.0% by weight of one or more anti-erythematous or anti-inflammatory substances selected from licochalcone A, lignin, chroman, isoflavonoids, pentacyclic triterpenes, hamamelis, chamomile extracts, bisabolol, allantoin, calendula extracts, panthenol.

9. The preparation of claim 1, wherein the preparation comprises, based on a total weight of the preparation, from 0.02 to 5.0% by weight of one or more polyols which comprise 1,2-decanediol, and from 0.01 to 5.0% by weight of one or more anti-erythematous or anti-inflammatory substances which comprise licochalcone A.

10. A method for the treatment or alleviation of atopic dermatitis in a patient in need thereof, wherein the method comprises applying the preparation of claim 1 onto skin affected by atopic dermatitis in an amount which is effective for treating or alleviating atopic dermatitis.

11. The method of claim 10, wherein the preparation further comprises menthoxypropanediol.

12. A topical cosmetic or dermatological preparation, wherein the preparation is suitable for the treatment and/or prophylaxis of atopic dermatitis and comprises, based on a total weight of the preparation, from 0.01 to 5.0% by weight of one or more TRPM-8 receptor agonists which comprise one or more of linalool, geraniol, hydroxycitronellal, 1,4-dioxaspiro[4.5]-decane-2-methanol, 5-methyl-2-prop-1-en-2-ylcyclohexan-1-ol, (1R,2S,5R)—N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide, from 0.02 to 5.0% by weight of one or more polyols selected from 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, and from 0.01 to 5.0% by weight of one or more anti-erythematous or anti-inflammatory substances selected from licochalcone A, lignin, chroman, isoflavonoids, pentacyclic triterpenes, hamamelis, chamomile extracts, bisabolol, allantoin, calendula extracts, panthenol.

13. The preparation of claim 12, wherein the one or more TRPM-8 receptor agonists comprise one or more of 1,4-dioxaspiro[4.5]-decane-2-methanol, 5-methyl-2-prop-1-en-2-ylcyclohexan-1-ol, (1R,2S,5R)—N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide.

14. The preparation of claim 12, wherein the one or more TRPM-8 receptor agonists additionally comprise menthoxypropanediol.

15. The preparation of claim 12, wherein the one or more polyols comprise 1,2-decanediol.

16. The preparation of claim 12, wherein the one or more anti-erythematous or anti-inflammatory substances comprise licochalcone A.

17. The preparation of claim 16, wherein the preparation comprises a Glycyrrhiza Inflata Root extract that contains licochalcone A.

18. The preparation of claim 12, wherein the preparation comprises, based on a total weight of the preparation, from 0.02 to 5.0% by weight of one or more polyols which comprise 1,2-decanediol, and from 0.01 to 5.0% by weight of one or more anti-erythematous or anti-inflammatory substances which comprise licochalcone A.

19. A method for the treatment or alleviation of atopic dermatitis in a patient in need thereof, wherein the method comprises applying the preparation of claim 12 onto skin affected by atopic dermatitis in an amount which is effective for treating or alleviating atopic dermatitis.

20. The method of claim 19, wherein the preparation further comprises menthoxypropanediol.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) The examples below serve to illustrate the present invention without limiting it. Unless stated otherwise, all amounts, fractions and percentages are based on the weight and the total amount or on the total weight of the preparations.

(2) TABLE-US-00001 Formulation examples 1 2 3 4 % by % by % by % by INCI name weight weight weight weight Stearic Acid 2.5 2.0 2.0 2.5 Glyceryl Stearate 1.0 1.0 1.0 1.0 C12-15 Alkyl Benzoate 3.0 5.00 3.0 2.0 Caprylic Acid/Capric Acid 2.5 2.50 2.0 2.5 Triglycerides Isopropyl Palmitate 2.0 — — 2.0 Cetylstearyl Alcohol 3.0 — 2.0 3.0 Cetyl Alcohol — 2.00 — — Stearyl Alcohol — 2.00 1.0 — Cyclomethicone 1.0 1.0 0.5 — Dicaprylyl Carbonate 2.0 2.00 2.00 2.0 Dimethicone 1.0 — 0.5 1.0 Glycerol 5 7.0 5.0 9.0 Methylparaben 0.2 — — — Phenoxyethanol 0.4 0.50 0.5 0.4 Propylparaben 0.1 — — 0.1 1,2-Hexanediol — — 0.1 0.1 Ethylhexylglycerol — — 0.2 — Methylisothiazolinone — 0.05 — — Butylene glycol — — 2.0 — Carbomer 0.15 0.10 0.15 0.1 Carrageenan 0.10 — 0.10 — Xanthan Gum — — 0.10 — Acrylates/C10-30 Alkyl Acrylate — 0.10 — 0.1 Crosspolymer Trisodium EDTA 0.20 0.20 0.2 0.2 Tapioca Starch 1.5 1.0 — Nylon-12 — 0.2 — 0.5 Polymethylsissesquioxane — 1.0 1.0 — Aluminum Starch Octenylsuccinate — — 1.0 — Distarch Phosphate 1.0 — — 1.0 Butyl Methoxydibenzoylmethane 1.00 2.00 1.00 1.00 Phenylbenzimidazole — 1.00 2.00 — Sulfonic Acid Octocrylene — 2.00 1.00 — Ethylhexyl Salicylate 1.00 — — 1.00 3-(Menthoxy)propane-1,2-diol 0.001 — 1.00 0.10 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.10 0.030 — 0.30 yl)-2-ispropyl-5-methyl- cyclohexane-carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.10 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.05 0.025 Sodium Hydroxide q.s. q.s. q.s. q.s. Hydroxyisohexyl 0.1 — — 0.05 3-cyclohexenecarboxaldehyde Citronellol 0.05 0.1 — 0.05 Linalool — 0.05 0.1 — Perfume 0.3 0.2 0.2 0.2 Sodium Hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(3) TABLE-US-00002 Formulation examples 5 6 7 8 % by % by % by % by INCI name weight weight weight weight Glyceryl Stearate Citrate 2.0 1.5 2.0 2.0 Behenyl Alcohol 1.5 1.0 1.0 1.0 C12-15 Alkyl Benzoate 2.0 2.5 2.0 2.5 Caprylic Acid/ 2.0 2.0 2.5 2.5 Capric Acid Triglyceride Cetyl Alcohol 2.0 2.0 — 2.0 Cetylstearyl Alcohol — — 2.0 — Cyclomethicone 1.0 1.0 2.0 2.0 Dicaprylyl Carbonate — 2.0 2.5 2.5 Paraffinum Liquidum — — 0.5 — Octyldodecanol — 2.0 — — Dimethicone 0.5 1.00 1.00 — Glycerol 3.00 5.00 7.00 9.00 Methylparaben 0.20 0.15 — — Phenoxyethanol 0.40 0.60 0.5 0.50 Propylparaben 0.10 — — — Methylisothiazolinone — — 0.05 — Piroctone Olamine — — — 0.15 Glyceryl Caprylate — — — 0.2 Carbomer 0.20 — 0.15 0.15 Sodium Polyacrylate — 0.4 — — Xanthan Gum 0.10 — 0.10 — Acrylates/C10-30 Alkyl Acrylate — 0.1 — 0.1 Crosspolymer Tapioca Starch 0.50 — 0.50 — Nylon-12 1.0 — — 1.0 Polymethylsilsesquioxane — 1.0 1.0 — Aluminum starch Octenylsuccinate — 1.0 — 1.00 3-(Menthoxy)propane-1,2-diol 0.01 — 1.0 0.10 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.20 0.10 — 0.30 yl)-2-ispropyl-5-methyl- cyclohexane-carboxamide 1,2-Decanediol 0.10 0.20 0.30 0.20 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.05 0.03 Titanium Dioxide — 1.0 — — Octocrylene — 1.0 — 2.0 Bis-Ethylhexyloxyphenol — 1.0 1.0 — Methoxyphenyl Triazines 2-Ethylhexyl Methoxycinnamate — 1.0 2.0 2.0 Homosalate (3,3,5-trimeth- — — 1.0 1.0 ylcyclohexyl salicylate) Sodium Hydroxide q.s. q.s. q.s. q.s. 1-(1,2,3,4,5,6,7,8-Octahy- 0.1 — q.s. q.s. dro-2,3,8,8-tetramethyl- 2-naphthyl)ethan-1-one Geraniol — 0.05 — — Hexylcinnamal — — 0.05 — Perfume 0.1 0.2 0.3 0.2 Water ad 100 ad 100 ad 100 ad 100

(4) TABLE-US-00003 Formulation examples 9 10 11 12 % by % by % by % by INCI name weight weight weight weight Polyglyceryl-3 Methylglucose 2.00 2.50 2.50 2.50 Distearate Sorbitan Stearate 1.50 3.00 1.50 3.00 C12-15 Alkyl Benzoate 2.50 2.50 2.50 2.50 Caprylic Acid/Capric Acid 2.50 2.50 2.50 2.50 Triglycerides Stearyl Alcohol 1.00 1.50 1.00 1.50 Cyclomethicone 3.00 1.00 2.00 1.00 Isopropyl Myristate — 2.50 2.0 2.50 Isopropyl Palmitate 2.0 — 1.0 — Dimethicone — 1.00 — 1.00 Glycerol 5.00 7.50 3.00 7.50 Butyrospermum Parkii Butter 2.0 — — — Methylparaben 0.20 0.20 — 0.1 Phenoxyethanol 0.40 0.40 0.40 0.40 Propylparaben 0.10 — — — Benzethonium Chloride — — 0.1 — Caprylyl Glycol — 0.2 — — Ethylhexylglycerol — 0.2 — 0.2 Carbomer 0.15 0.10 0.15 0.10 Ammonium — 0.2 — 0.2 Acryloyldimethyltaurate/VP Copolymer Carrageenan 0.1 — 0.15 — Trisodium EDTA — 1.00 — 1.00 Tapioca Starch — 1.00 1.0 — Distarch Phosphate — 1.00 — 1.0 Acrylonitrile-methacry- — — 1.0 1.0 lonitrile-methyl- methacrylate Copolymer + Isopentane + Magnesium Hydroxide 3-(Menthoxy)propane-1,2-diol 0.05 1.0 — 0.10 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.20 0.10 0.10 0.30 yl)-2-ispropyl-5-methyl- cyclohexane-carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.30 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.05 0.03 Diethylamino Hydroxybenzoyl — — 1.0 — Hexyl Benzoate Ethylhexyl Methoxycinnamate — 1.00 — 2.00 Butyl Methoxydibenzoylmethane — 2.00 — 2.00 Octocrylene — 1.00 2.0 1.00 Titanium Dioxide — — 1.0 — Sodium Hydroxide q.s. q.s. q.s. q.s. Sodium Metabisulfite — 0.15 — — BHT (tert-Butylhydroxytoluene) — — 0.05 — Linalyl Acetate 0.05 — — — Hexyl Salicylate — 0.05 — — Benzyl Salicylate — — 0.01 — Perfume q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(5) TABLE-US-00004 Formulation examples 13 14 15 16 % by % by % by % by INCI name weight weight weight weight PEG-40 Stearate 0.80 1.00 1.00 1.00 Glyceryl Stearate 2.50 3.00 3.00 3.00 C12-15 Alkyl Benzoate 2.00 2.50 2.00 2.00 Caprylic Acid/ 2.00 2.50 2.50 2.00 Capric Acid Triglycerides Cetylstearyl Alcohol 3.00 3.00 3.00 3.00 Cyclomethicone 2.00 2.00 2.00 2.00 Dicaprylyl Carbonate — 2.00 2.50 2.50 Octyldodecanol 1.0 — — 1.50 Butyrospermum Parkii Butter 2.0 — — — Octyldodecyl Myristate 1.0 — 1.5 1.0 Dimethicone 1.00 1.00 1.00 1.00 Glycerin 7.50 5.0 9.0 7.50 Methylparaben 0.20 — 0.1 — Phenoxyethanol 0.40 0.50 0.40 0.40 Propylparaben 0.10 — — — Glyceryl Caprylate — 0.25 — — Pentylene Glycol — 0.5 — — Butylene Glycol — — 3.0 — Carbomer 0.15 0.10 0.10 0.15 Sodium Polyacrylate — 0.20 0.20 — Xanthan Gum 0.10 — — — Acrylates/C10-30 Alkyl Acrylate — — — 0.1 Crosspolymer Trisodium EDTA + — 1.00 1.00 1.00 Water (20% strength solution) Tapioca Starch — 1.00 1.00 1.00 Distarch phosphate — 1.00 1.00 1.00 Aluminum Starch Octenylsuccinate 2.0 — — — Acrylonitrile- 1.0 — — — methacrylonitrile-methyl- methacrylate Copolymer + Isopentane + Magnesium Hydroxide 3-(Menthoxy)propane-1,2-diol 0.05 0.10 — 0.10 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.20 — 0.10 0.30 yl)-2-ispropyl-5-methyl- cyclohexane-carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.30 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.05 0.03 Ethylhexyl Methoxycinnamate — 1.00 1.00 2.00 Diethylamino Hydroxybenzoyl — 1.00 — 1.00 Hexyl Benzoate Titanium Dioxide — — 1.0 — Homosalate (3,3,5-trimeth- — — 2.0 — ylcyclohexyl salicylate) Phenylbenzimidazole — — 1.0 — Sulfonic Acid Sodium hydroxide q.s. q.s. q.s. q.s. 3-Methyl-5-phenyl-1-pentanol 0.1 — — — Coumarin — 0.05 — — Ethyllinalool — — 0.1 — Perfume q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(6) TABLE-US-00005 Formulation examples 17 18 19 20 % by % by % by % by INCI name weight weight weight weight PEG-40 Stearate 1.00 1.00 1.00 1.00 Glyceryl Stearate 2.00 2.50 2.50 2.00 C12-15 Alkyl Benzoate — — 1.00 — Caprylic Acid/ 6.00 4.00 5.00 6.00 Capric Acid Triglycerides Glyceryl Caprylate — 1.00 0.50 — Cetyl Alcohol 2.00 3.00 2.00 2.00 Cyclomethicone 3.00 2.50 2.50 3.00 Pentaerythrityl Tetraisostearate 4.00 3.00 4.50 4.00 Triisostearin 3.00 4.00 3.50 3.00 Oenothera Biennis Oil 3.00 2.00 2.00 3.00 (evening primrose oil) Vitis Vinifera Seed Oil 3.00 4.00 4.00 3.00 (grape seed oil) Ceramide III 0.05 0.10 0.1 0.05 Dimethicone 5.00 3.00 4.00 5.00 Glycerol 10.00 8.00 9.00 10.00 Pirctone Olamine 0.10 0.05 0.15 0.10 Phenoxyethanol 0.20 0.40 0.30 0.20 1,2-Hexanediol 0.50 — 0.30 0.50 1,2-Decanediol 0.20 0.25 0.30 0.20 BHT (tert-Butylhydroxytoluene) 0.05 0.05 0.05 0.05 Trisodium EDTA + Water 0.50 1.00 1.00 0.50 (20% strength aqueous solution) 3-(Menthoxy)propane-1,2-diol 0.05 0.10 — 0.10 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.20 — 0.10 0.30 yl)- 2-ispropyl-5-methylcyclohexane- carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.20 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.05 0.03 Menthoxypropanediol 0.10 0.15 0.20 0.10 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.05 0.10 0.20 0.10 yl)-2-ispropyl-5-methyl- cyclohexane-carboxamide 1-(1,2,3,4,5,6,7,8-Octahy- — 0.05 0.10 — dro-2,3,8,8-tetramethyl- 2-naphthyl)ethan-1-one Sodium Citrate 0.20 0.15 0.15 0.20 Citric Acid q.s. q.s. q.s. q.s. Xanthan Gum — — 0.10 — Water ad 100 ad 100 ad 100 ad 100

(7) TABLE-US-00006 Formulation examples 21 22 23 24 % by % by % by % by INCI name weight weight weight weight Glyceryl Stearate Citrate 2.0 2.0 2.0 2.0 Isopropyl Palmitate 3.0 2.0 3.0 1.0 Cetylstearyl Alcohol 4.0 3.0 3.0 — Cetyl Alcohol 4.0 Caprylic Acid/ 3.0 2.5 2.0 3.0 Capric Acid Triglycerides C12-15 Alkyl Benzoate 3.0 2.5 2.0 2.0 Cyclomethicone 1.0 — 1.0 — Dicaprylyl Carbonate — — 2.5 — Dimethicone — 0.50 — — Octyldodecyl Myristate — 1.0 — — Glycerol 4.00 6.00 5.00 6.00 Methylparaben 0.20 — 0.10 — Phenoxyethanol 0.40 0.40 0.40 0.40 Piroctone Olamine — — — 0.10 Ethylhexylglycerol — 0.3 — — Glyceryl Caprylate — 0.3 — — 2-Methyl-1,3-propanediol — 2.0 — 2.0 Carbomer 0.20 0.10 0.15 — Sodium Polyacrylate — 0.40 — — Xanthan Gum 0.10 — — 0.15 Acrylates/C10-30 — — 0.1 0.2 Alkyl Acrylate Crosspolymer Acrylonitrile- 0.50 — 0.50 — methacrylonitrile-methyl- methacrylate Copolymer + Isopentane + Magnesium Hydroxide Aluminum Starch — 1.00 — 1.00 Octenylsuccinate Methyl Methacrylate 1.0 — — 1.0 Crosspolymer 3-(Menthoxy)propane-1,2-diol — 0.50 0.10 0.03 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.10 — 0.05 0.10 yl)-2-ispropyl-5-meth- ylcyclohexane-carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.30 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.10 0.05 Bis-Ethylhexyloxyphenol — — 1.0 — Methoxyphenyl Triazines Titanium Dioxide — 1.00 — 1.00 Octocrylene — 1.00 1.0 1.00 Butyl Methoxydibenzoylmethane — 1.00 — 1.00 Ethylhexyl Salicylate — — 1.0 — Citronellol 0.05 — 0.05 — Coumarin 0.05 0.05 — 0.05 Triethyl Citrate — — 0.05 0.05 Sodium Hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(8) TABLE-US-00007 Formulation examples 25 26 27 28 % by % by % by % by INCI name weight weight weight weight Sucrose Polystearate + 1.00 1.00 2.00 2.00 Hydrogenated Polyisobutene Sodium Stearoyl Glutamate 0.20 0.20 0.30 0.30 C12-15 Alkyl Benzoate 1.50 1.50 — — Cetyl Alcohol 0.50 0.50 — — Cyclomethicone 10.00 10.00 5.00 5.00 Dimethicone 3.00 3.00 2.50 2.50 Glycerol 7.50 7.50 5.00 5.00 Isopropyl Stearate 1.00 1.00 2.00 2.00 Paraffinum Liquidum 3.00 3.00 1.00 1.00 Methylparaben 0.10 — — 0.10 Ethylhexylglycerol — — 0.3 0.10 Propylparaben 0.1 — — — Methylisothiazolinone — 0.05 — — Phenoxyethanol 0.40 0.50 0.40 0.40 3-(Menthoxy)propane-1,2-diol 0.05 0.50 0.10 0.05 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.10 0.10 0.05 0.10 yl)- 2-ispropyl-5-methylcyclohexane- carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.30 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.10 0.05 Ethylhexyl Methoxycinnamate 3.00 2.00 3.00 3.0 Butyl Methoxydibenzoylmethane 2.00 2.00 1.00 1.0 Phenylbenzimidazole — 1.5 — 1.0 Sulfonic Acid Butylene Glycol — — 3.0 — Polymethylsissesquioxane — — 1.0 1.0 Nylon-12 — 1.0 1.0 — Distarch Phosphate — 1.0 — 1.0 Methyl Methacrylate Crosspolymer 1.0 — — — Aluminum Starch Octenylsuccinate 1.0 — — — Ammonium Acryloyldimeth- — — 0.25 0.25 yltaurate/VP Copolymer Xanthan Gum 0.10 — — 0.1 Acrylates/C10-30 Alkyl Acrylate 0.25 0.1 — — Crosspolymer Carbomer — 0.1 0.1 — Hexylcinnamal 0.05 0.1 — 0.1 1-(1,2,3,4,5,6,7,8-Octahy- — 0.1 0.1 — dro-2,3,8,8-tetramethyl- 2-naphthyl)ethan-1-one Linalool — — 0.05 0.05 Perfume 0.2 0.2 0.2 0.2 Sodium Hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(9) TABLE-US-00008 Formulation examples 29 30 31 32 % by % by % by % by INCI name weight weight weight weight Sodium Cetearyl Sulfate 0.15 0.15 0.15 0.15 Glyceryl Stearate SE 2.00 2.00 1.50 1.50 C12-15 Alkyl Benzoate 2.50 2.50 2.50 2.50 Octyldodecanol 1.00 1.00 — — Caprylic Acid/ 2.00 2.00 2.00 2.00 Capric Acid Triglycerides Cetylstearyl Alcohol 2.00 2.00 3.00 1.00 Cyclomethicone 1.50 1.50 2.50 2.50 Dimethicone 0.50 0.50 0.50 0.50 Glycerol 5.00 5.00 7.50 7.50 Isopropyl Stearate 3.00 3.00 2.00 2.00 Paraffinum Liquidum 2.00 2.00 1.00 1.00 Methylisothiazolinone — — — 0.05 Phenoxyethanol 0.4 0.5 0.40 0.30 Methylparaben 0.15 — — — Propylparaben 0.1 — — — Piroctone Olamine — 0.15 — — Benzethonium Chloride — — 0.10 — 3-(Menthoxy)propane-1,2-diol — 0.50 0.10 0.05 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.10 — 0.05 0.10 yl)-2-ispropyl-5-meth- ylcyclohexane-carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.30 Glycyrrhiza Inflata 0.025 0.05 0.10 0.05 Root Extract Ethylhexyl Methoxycinnamate 3.00 3.00 5.00 5.00 Butyl Methoxydibenzoylmethane 1.00 1.00 2.00 2.00 Pentylene Glycol — 1.0 1.0 — Butylene Glycol 1.0 1.5 3.0 3.0 2-Methyl-1,3-propanediol — — — — 1,2-Hexanediol — — — 1.0 Nylon-12 1.0 1.0 1.0 1.0 Carbomer — — 0.10 0.15 Ammonium Acryloyldimeth- 0.20 — — — yltaurate/VP Copolymer Chondrus Crispus 0.10 0.10 — — Xanthan Gum — — 0.10 — Acrylates/C10-30 — 0.2 0.1 0.1 Alkyl Acrylate Crosspolymer Coumarin 0.1 — 0.05 0.05 Hydroxyisohexyl 0.05 0.05 0.05 0.1. 3-cyclohexenecarboxaldehyde 1-(1,2,3,4,5,6,7,8-Octahy- — 0.05 0.1 — dro-2,3,8,8-tetramethyl- 2-naphthyl)ethan-1-one Perfume 0.2 0.3 0.4. 0.2. Sodium Hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(10) TABLE-US-00009 Formulation examples 33 34 35 36 % by % by % by % by Chemical name weight weight weight weight Sodium Cetearyl Sulfate 0.15 0.15 0.2 0.2 Glyceryl Stearate, 2 2 1.5 1.5 self-emulsifying C12-15 Alkyl Benzoate 2 2 2 2 Octyldodecanol 1 1 — — Caprylic Acid/ 2 2 2 2 Capric Acid Triglycerides Cetylstearyl Alcohol 2 2 1 1 Cyclomethicone 1 1 2 2 Dimethicone 0.5 0.5 1 1 Glycerol 5 5 7.5 7.5 Isopropyl Palmitate 2.5 2.5 2 2 DMDM Hydantoin 0.05 0.05 0.05 0.05 Phenoxyethanol 0.35 0.25 0.3 0.3 Ethanol 3.0 2.0 Pentylene Glycol 1.0 1.0 1.5 3-(Menthoxy)propane-1,2-diol — 0.50 0.10 0.05 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.10 — 0.05 0.10 yl)-2-ispropyl-5-methyl- cyclohexane-carboxamide 1,2-Decanediol 0.30 0.30 0.30 0.30 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.10 0.05 Carbomer 0.2 0.2 0.2 0.2 Carrageenan 0.1 0.1 — — Xanthan Gum — — 0.2 0.2 Acrylates/C10-30 Alkyl Acrylate — — — 0.15 Crosspolymer Sodium Polyacrylate — 0.2 — — Diethylhexyl 2,6-Naphthalate — — 1.0 — Phenylbenzimidazole Sulfonic acid — 1.0 — 2.0 Titanium Dioxide — — 1.0 — Diethylamino Hydroxybenzoyl — — 1.0 1.0 Hexyl Benzoate Octocrylene — 4.0 2.0 3.0 3,3,5-Trimeth- 1.0 — — ylcyclohexylsalicylate Distarch phosphate — 1.0 1.0 — Methyl Methacrylate Crosspolymer 1.0 — — 1.0 Polymethylsissesquioxane — — 1.0 1.0 Acrylonitrile- 1.0 1.0 — — methacrylonitrile-methyl- methacrylate Copolymer + Isopentane + Magnesium Hydroxide 1-(1,2,3,4,5,6,7,8-Octahy- — 0.1 0.1 0.05 dro-2,3,8,8-tetramethyl- 2-naphthyl)ethan-1-one Hydroxyisohexyl 0.05 0.05 0.1 — 3-cyclohexenecarboxaldehyde Linalyl Acetate 0.1 — 0.05 0.05 Perfume 0.15 0.15 0.3 0.3 Sodium Hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(11) TABLE-US-00010 Formulation examples 37 38 39 40 % by % by % by % by Chemical name weight weight weight weight Polyglyceryl-10 Stearate 0.2 0.2 0.15 0.15 C12-15 Alkyl Benzoate 2.5 2.5 2.0 3.0 Isopropyl Palmitate 2.5 2.5 2.0 2.0 Caprylic Acid/ 2.0 2.5 1.0 2.0 Capric Acid Triglycerides Glyceryl Stearate 1.0 1.0 0.5 0.5 Octyldodecanol 0.5 — — 1.0 Cyclomethicone — — 0.5 0.5 Butyl Methoxydibenzoylmethane — 2.0 2.0 — Octocrylene — 2.0 3.0 2.0 Ethylhexyl Salicylate — 1.0 1.0 — Phenylbenzimidazole — 1.0 — 1.5 Sulfonic Acid Titanium Dioxide — 1.0 — 1.0 3,3,5-Trimethyl — — 1.0 1.0 cyclohexylsalicylate Glycerol 9.0 5.0 7.0 7.0 Tapioca Starch 1.0 1.0 — — Acrylonitrile- — 1.0 0.5 — methacrylonitrile-methyl- methacrylate Copolymer + Isopentane + Magnesium Hydroxide Aluminum Starch Octenylsuccinate — — 1.0 1.0 Distarch phosphate — — — 1.0 Methylisothiazolinone 0.05 0.05 — — Phenoxyethanol 0.5 0.5 0.4 0.4 Benzethonium Chloride — — 0.1 — Ethylhexylglycerol — — 0.1 — Methylparaben — — — 0.2 Carbomer 0.25 0.2 0.2 0.2 Acrylates/C10-30 Alkyl 0.2 — — 0.15 Acrylate Crosspolymer Ammonium Acryloyldimeth- — 0.25 — — yltaurate/VP Copolymer Sodium Polyacrylate — — 0.3 — Xanthan Gum — — — 0.15 3-(Menthoxy)propane-1,2-diol — 0.50 0.10 0.05 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.10 — 0.05 0.10 yl)-2-ispropyl- 5-methylcyclohexanecarboxamide 1,2-Decanediol 0.30 0.30 0.20 0.30 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.10 0.05 Ethanol 3.0 3.0 — — Butylene Glycol — — 2.0 2.0 Coumarin — 0.05 0.05 — Hexylcinnamal 0.05 0.05 — 0.05 Hexyl Salicylate — — 0.05 0.05 Perfume 0.15 0.2 0.25 0.3 Sodium Hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100

(12) TABLE-US-00011 Formulation examples 41 42 43 44 % by % by % by % by Chemical name weight weight weight weight Potassium Cetylphosphate 0.20 0.20 0.25 0.20 C12-15 Alkyl Benzoate 2.5 2.5 2.0 2.0 Isopropyl Palmitate 2.5 2.5 — 3.0 Isopropyl Stearate — — 2.0 — Caprylic Acid/ 2.5 2.5 1.5 2.0 Capric Acid Triglycerides Glyceryl Stearate 1.0 1.0 1.25 1.5 Octyldodecanol — — 1.5 — Paraffinum Liquidum — — — 1.0 Glycerol 5.0 7.0 9.0 6.0 Bis-Ethylhexyloxyphenol — 1.0 — 1.0 Methoxyphenyl Triazines Titanium Dioxide + — — 1.0 1.0 Trimethoxycaprylylsilane Phenylbenzimidazole — — 1.0 1.0 Sulfonic Acid Butyl Methoxydibenzoylmethane 1.0 — 2.0 2.0 Disodium Phenyl Dibenzimidazole — 1.5 1.0 — Tetrasulfonate Ethylhexyltriazone 1.0 — — — Ethylhexyl Methoxycinnamate + 2.0 — — — BHT Carbomer 0.15 0.2 0.3 Acrylates/C10-30 Alkyl 0.3 0.1 0.15 — Acrylate Crosspolymer Xanthan Gum 0.15 0.1 Methylisothiazolinone 0.05 — — — Phenoxyethanol 0.5 0.5 0.4 0.4 Methylparaben — 0.1 — — Ethylhexyl Salicylate — — 0.3 — Butylene Glycol — — 3.0 3.0 Benzethonium Chloride — — — 0.1 3-(Menthoxy)propane-1,2-diol — 0.50 0.10 0.05 (1R,2S,5R)-N-(2-(2-Pyridinyl)eth- 0.10 — 0.03 0.10 yl)-2-ispropyl- 5-methylcyclohexanecarboxamide 1,2-Decanediol 0.20 0.30 0.10 0.30 Glycyrrhiza Inflata Root Extract 0.025 0.05 0.10 0.05 Linalool 0.05 — — 0.05 Hexylcinnamal 0.05 0.05 — — 1-(1,2,3,4,5,6,7,8-Octahy- — — 0.1 — dro-2,3,8,8-tetramethyl- 2-naphthyl)ethan-1-one Perfume 0.1 0.3. 0.2 0.3 BHT (tert-Butylhydroxytoluene) 0.05 — — — Tocopheryl Acetate — 0.1 — — Sodium Hydroxide q.s. q.s. q.s. q.s. Water ad 100 ad 100 ad 100 ad 100