Method and apparatus for magnetic resonance data acquisition using a multipoint dixon technique
09823322 · 2017-11-21
Assignee
Inventors
- Stephan Kannengiesser (Wuppertal, DE)
- Marcel Dominik Nickel (Herzogenaurach, DE)
- Xiaodong Zhong (Lilburn, GA)
Cpc classification
A61B5/055
HUMAN NECESSITIES
G01R33/56518
PHYSICS
G01R33/485
PHYSICS
G01R33/4828
PHYSICS
International classification
G01R33/485
PHYSICS
G01R33/565
PHYSICS
Abstract
In a method and magnetic resonance (MR) apparatus to acquire MR data from a subject, a predetermined spectral model of a multipoint Dixon technique is used that includes at least two spectral components with respective associated relaxation rates, a first phase due to field inhomogeneities; and a second phase due to eddy current effects. MR data are acquired using a bipolar multi-echo MR measurement sequence for multiple image points wherein, for each image point, the multi-echo MR measurement sequence alternately uses positive and negative readout gradient fields for the readout of MR signals of the MR data at at least three echo times. The at least two spectral components are determined based on the MR data.
Claims
1. A method for acquiring magnetic resonance data from an examination subject, comprising: operating a magnetic resonance data acquisition unit, that generates a basic magnetic field in which an examination subject is situated, according to a bipolar multi-echo data acquisition sequence, to acquire magnetic resonance data from the examination subject for multiple image points by, for each image point, alternatingly activating positive and negative readout gradient fields with a gradient system of said acquisition unit, during which magnetic resonance signals are read out during at least three echo times, said activation of said gradient fields producing eddy currents in said data acquisition unit by interaction with said basic magnetic field; providing said magnetic resonance data to a computerized processor and, in said computerized processor, operating on said magnetic resonance data with a spectral model of a multipoint Dixon technique that relates said magnetic resonance data to at least two spectral components of said magnetic resonance signals and respective, associated relaxation rates of said at least two spectral components, and a first phase of said magnetic resonance signals that occurs due to field inhomogeneities of said basic magnetic field, and a second phase that occurs due to effects of said eddy currents, to implement an at least partially numerical determination of said at least two spectral components, said relaxation rates, said first phase, and said second phase; and making said at least two spectral components available in electronic form at an output of said processor in a format allowing reconstruction of an in-phase image and two out-of-phase images according to the multipoint Dixon technique that is modeled by said spectral model.
2. A method as claimed in claim 1 wherein said spectral model comprises a positive prefactor of said second phase for said magnetic resonance signals that are read out when said positive gradient fields are activated, and a negative prefactor of said second phase for said magnetic resonance signals that are read out when said negative readout gradient fields are activated.
3. A method as claimed in claim 1 comprising: in said computerized processor, determining a computational grid of lower resolution relative to a resolution of said magnetic resonance data, wherein each grid point of said computational grid includes a predetermined number of adjacent image points of said magnetic resonance data; and in said partially numerical determination of said first phase and said second phase, using an equation that is based on at least one of said first phase and said second phase being constant within a grid point of said computational grid.
4. A method as claimed in claim 1 comprising, in said at least partially numerical determination: implementing a first numerical optimization that determines said first phase; purging said magnetic resonance data of influences of said first phase depending on the determined first phase; implementing a second numerical optimization that determines said second phase; and purging the magnetic resonance data of influences of said second phase dependent on the determined second phase.
5. A method as claimed in claim 4 comprising: implementing said first numerical optimization to produce multiple result candidates for an image point; in said first optimization, implementing a region growing technique for said multiple image points in order to select a value for the multiple result candidates for each of said image points.
6. A method as claimed in claim 5 comprising implementing first numerical optimization, using an equation having no explicit dependency on at least one of said at least two spectral components.
7. A method as claimed in claim 4 comprising: implementing said second numerical optimization to produce multiple result candidates for an image point; in said second optimization, implementing of a region growing technique for said multiple image points in order to select a value for the multiple result candidates for each of said image points.
8. A method as claimed in claim 7 comprising implementing said second numerical optimization using an equation having no explicit dependency on at least one of said at least two spectral components.
9. A method as claimed in claim 4 comprising: implementing said first numerical optimization to produce multiple result candidates for an image point; in said first optimization, implementing of a region growing technique for said multiple image points in order to select a value for the multiple result candidates for each of said image points; implementing said second numerical optimization to produce multiple result candidates for an image point; and in said second optimization, implementing a region growing technique for said multiple image points in order to select a value for the multiple result candidates for each of said image points.
10. A method as claimed in claim 9 comprising implementing said first numerical optimization using an equation having no explicit dependency on at least one of said at least two spectral components, and implementing said second numerical optimization using an equation having no explicit dependency on at least one of said at least two spectral components.
11. A method as claimed in claim 10 wherein said equation used in implementing said first numerical optimization comprises a variable projection of complex-valued weightings of said at least two spectral components, and wherein said equation used in implementing said second numerical optimization comprises a variable projection of real-value weightings of said at least two spectral components.
12. A method as claimed in claim 11 wherein said equation used in implementing said second numerical optimization additionally comprises a phase at a first of said at least three echo times.
13. A method as claimed in claim 4 comprising: implementing said first numerical optimization using an equation having no explicit dependency on said second phase; and implementing said second numerical optimization using an equation that has no explicit dependency on said first phase.
14. A method as claimed in claim 4 comprising implementing said first numerical optimization using an equation that assumes a relaxation rate for said at least two spectral components that is equal to zero.
15. A method as claimed in claim 1 comprising determining said at least two spectral components with respective associated relaxation rates by: implementing a numerical optimization that determines said relaxation rates of said at least two spectral components; and implementing an analytical calculation of said at least two spectral components dependent on the determined relaxation rates.
16. A method as claimed in claim 15 comprising implementing said numerical optimization to determine said relaxation rate with no dependency on said first phase.
17. A method as claimed in claim 16 comprising giving said numerical optimization that determines said relaxation rates no dependency on said first phase by purging said magnetic resonance data of dependency on said first phase using a preceding numerical determination of said first phase.
18. A method as claimed in claim 15 comprising implementing said numerical optimization to determine said relaxation rates with no dependency on said second phase.
19. A method as claimed in claim 18 comprising giving said numerical optimization that determines said relaxation rates no dependency on said second phase by purging said magnetic resonance data of dependency on said second phase using a preceding numerical determination of said second phase.
20. A method as claimed in claim 15 comprising; implementing said numerical optimization to determine said relaxation rates with no dependency on said first phase; and implementing said numerical optimization to determine said relaxation rates with no dependency on said second phase.
21. A method as claimed in claim 20 comprising: giving said numerical optimization that determines said relaxation rates no dependency on said first phase by purging said magnetic resonance data of dependency on said first phase using a preceding numerical determination of said first phase; and giving said numerical optimization that determines said relaxation rates no dependency on said second phase by purging said magnetic resonance data of dependency on said second phase using a preceding numerical determination of said second phase.
22. A method as claimed in claim 15 comprising implementing said numerical optimization to determine said relaxation rates with no explicit dependency on said at least two spectral components using an equation comprising a variable projection of weightings of said at least two spectral components.
23. A magnetic resonance apparatus comprising: a magnetic resonance data acquisition unit comprising a basic field magnet that generates a basic magnetic field in which an examination subject is situated, and a gradient system; a control computer configured to operate the magnetic resonance data acquisition unit, according to a bipolar multi-echo data acquisition sequence, to acquire magnetic resonance data from the examination subject for multiple image points by, for each image point, alternatingly activating positive and negative readout gradient fields with said gradient system, during which magnetic resonance signals are read out at at least three echo times, said activation of said gradient fields producing eddy currents in said data acquisition unit by interaction with said basic magnetic field; a computerized processor provided with said magnetic resonance data said computerized processor, being configured to operate on said magnetic resonance data with a spectral model of a multipoint Dixon technique that relates said magnetic resonance data to at least two spectral components of said magnetic resonance signals and respective, associated relaxation rates of said at least two spectral components, and a first phase of said magnetic resonance signals that occurs due to field inhomogeneities of said basic magnetic field, and a second phase that occurs due to effects of said eddy currents, to implement an at least partially numerical determination of said at least two spectral components, said relaxation rates, said first phase, and said second phase; and said computerized processor being configured to make said at least two spectral components available in electronic form at an output of said processor in a format allowing reconstruction of an in-phase image and two out-of-phase images according to the multipoint Dixon technique that is modeled by said spectral model.
24. A method for acquiring magnetic resonance data from an examination subject, comprising: operating a magnetic resonance data acquisition unit, that generates a basic magnetic field in which an examination subject is situated, according to a bipolar multi-echo data acquisition sequence, to acquire magnetic resonance data from the examination subject for multiple image points by, for each image point, alternatingly activating positive and negative readout gradient fields with a gradient system of said acquisition unit, during which magnetic resonance signals are read out during at least three echo times; providing said magnetic resonance data to a computerized processor and, in said computerized processor, operating on said magnetic resonance data with a spectral model of a multipoint Dixon technique that relates said magnetic resonance data to at least two spectral components of said magnetic resonance signals and respective, associated relaxation rates of said at least two spectral components, and a first phase of said magnetic resonance signals that occurs due to field inhomogeneities of said basic magnetic field, and a different second phase that occurs due to effects of a source of disturbance to said magnetic resonance data other than said field inhomogeneities, to implement an at least partially numerical determination of said at least two spectral components, said relaxation rates, said first phase, and said second phase; and making said at least two spectral components available in electronic form at an output of said processor in a format allowing reconstruction of an in-phase image and two out-of-phase images according to the multipoint Dixon technique that is modeled by said spectral model.
25. A magnetic resonance apparatus comprising: a magnetic resonance data acquisition unit comprising a basic field magnet that generates a basic magnetic field in which an examination subject is situated, and a gradient system; a control computer configured to operate the magnetic resonance data acquisition unit, according to a bipolar multi-echo data acquisition sequence, to acquire magnetic resonance data from the examination subject for multiple image points by, for each image point, alternatingly activating positive and negative readout gradient fields with said gradient system, during which magnetic resonance signals are read out at at least three echo times; a computerized processor provided with said magnetic resonance data said computerized processor, being configured to operate on said magnetic resonance data with a spectral model of a multipoint Dixon technique that relates said magnetic resonance data to at least two spectral components of said magnetic resonance signals and respective, associated relaxation rates of said at least two spectral components, and a first phase of said magnetic resonance signals that occurs due to field inhomogeneities of said basic magnetic field, and a different second phase that occurs due to effects of a source of disturbance to said magnetic resonance data other than said field inhomogeneities, to implement an at least partially numerical determination of said at least two spectral components, said relaxation rates, said first phase, and said second phase; and said computerized processor being configured to make said at least two spectral components available in electronic form at an output of said processor in a format allowing reconstruction of an in-phase image and two out-of-phase images according to the multipoint Dixon technique that is modeled by said spectral model.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1)
(2)
(3)
(4)
(5)
(6)
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(8)
DESCRIPTION OF THE PREFERRED EMBODIMENTS
(9) In the following, the present invention is explained in detail using preferred embodiments with reference to the drawings. In the figures, identical reference characters designate identical or similar elements. The subsequent description of embodiments with reference to the figures should not be construed as limiting. The figures are purely illustrative.
(10) The figures are schematic representations of different embodiments of the invention. Elements presented in the figures are not necessarily shown true to scale. Rather, the different elements presented in the figures are rendered such that their function and general purpose are comprehensible to those skilled in the art. Connections and couplings between functional units and elements that are depicted in the figures can be implemented as indirect connections or couplings. A connection or coupling can be implemented via wires or wirelessly. Functional units can be implemented as hardware, software or a combination of hardware and software.
(11) In the following, techniques are presented by means of which at least a first spectral component and a second spectral component are determined from MR data. For example, the first spectral component can indicate a fat content (shortened to fat in the following) and the second spectral component can indicate a water content (shortened to water in the following). In general, however, any spin species can be considered, thus also silicone, for instance.
(12) The MR data are acquired with a multipoint Dixon technique, thus the MR data are acquired from at least three MR signals respectively at different echo times. A spectral model is also used that, in addition to the fat component and water component, also takes into account a first phase due to field inhomogeneities and a second phase due to eddy current effects. Weightings of the fat component and of the water component that are considered in the spectral model can typically be assumed to be real values, but it is also possible to assume the weightings to be complex-valued.
(13) The signal D.sub.e(x) in the image point x can be modeled via the following spectral model:
(14)
wherein e designates the MR signals at various echo time T.sub.E,e, W(x) corresponds to the weighting of the water component, F(x) corresponds to the weighting of the fat component, and R*.sub.2,water.sup.(x) and R*.sub.2,fat.sup.(x) are relaxation constants for the water component and fat component. Furthermore, Ω(x) designates the first phase, φ(x) designates a phase at the first echo time, and φ.sub.EC(x) designates the second phase. The prefactor α.sub.e for the second phase is either +1 or −1, depending on an orientation of the readout gradient field. In the following, a direction of the readout gradient field is designated as even if α.sub.e=+1 and the opposite direction is designated as odd if α.sub.e=−1. d.sub.e and c.sub.e also designate predetermined phase factors for each MR signal that respectively designate the phase evolution of the water component and of the fat component. For water, d.sub.e=1 is assumed in the following, while c.sub.e can be calculated. It is possible that d.sub.e and c.sub.e are predetermined.
(15) In general, the weightings W and F are chosen to be complex-valued, wherein in such a case the phase φ(x) at the first echo time is equal to zero. However, it is also possible that W and F are assumed to have real values, wherein in such a case the phase φ(x) at the first echo time can be designated as the phase that is extrapolated directly after the excitation.
(16) The spectral model discussed in the preceding can also be represented as
(17)
and N.sub.e designates the number of echoes.
(18) In a simple embodiment, the following equation can be optimized within the scope of a chi-square optimization:
x.sup.2=∥φAv−D∥.sup.2, (4)
(19) For example, this can take place separately for each image point. In such a case, however, ambiguities can occur in the solution. The underlying problem is that the problem described by Equation (4) has different local minima in Ω and φ.sub.EC. In particular, the problem described by Equation (4) is periodic if the echo times are equidistant. In such a case, the global minimum may not coincide with the actual physical condition due to the noise and imperfections of the considered spectral model.
(20) Therefore, it is assumed that the field inhomogeneities have a relatively low spatial dependency, meaning that the first phase Ω(x) varies relatively less strongly in location. This information can be used to determine a solution to Equation (4). A corresponding assumption can be made for the eddy current effects. In the present approach, for example, via the assumption of the first phase and/or second phase these can be considered to be constant in parts.
(21) In other words: the predetermined spectral model according to Equations (1)-(3) includes at least the at least two spectral components F, W with respective associated relaxation rates, a first phase Ω due to field inhomogeneities and a second phase φ.sub.EC due to eddy current effects.
(22) As noted, a spectral model corresponding to Equation (1) can also be directly set up for other species than fat and water, but for simplicity only water and fat are referred to for the purpose of better illustration.
(23) In the following, techniques are now explained which enable a determination of the first and second spectral components W(x), F(x) on the basis of the spectral model, i.e. on the basis of Equations 1-3. However, the fundamentals of the MR system that can be used for the MR measurement are initially explained with reference to
(24) In
(25) To excite the nuclear spins (i.e., to deflect them from the polarization or alignment from the magnetization in the longitudinal direction that result in the basic magnetic field) an RF coil arrangement 121 is provided that radiates an amplitude-modulated RF excitation pulse in the examined person 101. A transverse magnetization of the nuclear spins is thereby produced. To generate such RF excitation pulses, an RF transmission unit 131 is connected via an RF switch 130 with the RF coil arrangement 121. The RF transmission unit 131 can have an RF generator and an RF amplitude modulation unit. The RF excitation pulses deflect (“flip”) the nuclear spins out of the steady stage to produce the transversal magnetization in 1D (slice-selectively) or 2D/3D (spatially selectively or globally).
(26) Furthermore, an RF acquisition unit 132 is coupled via the RF switch 130 with the RF coil arrangement 121. With the RF acquisition unit 132, MR signals of the relaxing transverse magnetization (for example due to inductive injection into the RF coil arrangement 121) can be acquired as MR data.
(27) In general, it is possible to use separate RF coil arrangements 121 for the radiation of the RF excitation pulses by means of the RF transmission unit 131 and for the acquisition of the MR data by means of the RF acquisition unit 132. For example, a volume coil 121 can be used for the radiation of RF pulses and a surface coil (not drawn), which may be an array of RF coils, can be used for the acquisition of raw data. For example, the surface coil can include 32 individual RF coils for the acquisition of the raw data, and therefore can be particularly suitable for partially parallel imaging (PPA, partially parallel acquisition). Appropriate techniques are known to those skilled in the art, and thus need not be explained in detail herein.
(28) The MR system 100 furthermore has an operating unit 150 that, for example, can include a monitor, a keyboard, a mouse etc. User entries can be detected and displayed as an output to the user by the operating unit 150. For example, via the operating unit 150, individual operating modes or operating parameters of the MR system can be set by the user and/or automatically and/or via remote control.
(29) Furthermore, the MR system 100 has a computer 160. For example, the computer 160 is configured to implement diverse computation operations within the scope of the determination of the fat component and the water component. For example, the computer 160 can be configured to implement a numerical optimization and/or analytical computation steps; and/or to eliminate influences of the first and/or second phase from the MR data; and/or to process MR data with a Fourier transformation.
(30) In
(31)
(32) Within the scope of a multipoint Dixon MR measurement sequence, MR signals can also be acquired at more than three echo times 21, 22, 23. For example, this can take place by continuing the application of the alternating readout gradient fields 16-1, 16-2, 16-3.
(33) The RF excitation pulse 15 deflects the magnetization out of its steady state along the longitudinal direction, so that the aforementioned transverse component is produced. The transverse component is typically in the x-y plane (see
(34) In
(35) As is explained in the preceding with regard to Equations 1-4, the spectral model can be used to determine the water component 35 and the fat component 36, respectively for each image point 30 of the MR data 25 (see
(36) Alternatively or additionally, the first phase Ω(x) and/or the second phase φ.sub.EC(x) can be assumed to be constant within a defined region. This is shown in
(37) The water component 35 and the fat component 36 in
(38) In the following, techniques are presented in which it is assumed, within the scope of a numerical optimization, that the first phase Ω(x) and/or the second phase φ.sub.EC(x) are respectively constant within a grid point 40 of the computation grid. The first phase Ω(x) and/or the second phase φ.sub.EC(x) can thus also be designated as constant in parts subparts). It is therefore possible to particularly simply determine the water component 35 and the fat component 36.
(39) In the example of
(40) Starting from Equation (4), the formulation can then be made:
(41)
wherein U=N.sub.x×N.sub.y×N.sub.z designates the computation grid, and U designates a grid point 40.
(42) For example, it is possible to determine the first phase Ω(x) within the scope of a first numerical optimization; the acquired MR data are subsequently purged of influences of the (now determined) first phase Ω(x). The second phase φ.sub.EC(x) can subsequently be determined within the scope of a second numerical optimization, and the acquired MR data can be purged of influences of the (now determined) second phase.
(43) For example, in this regard it is possible for the equation on which the first numerical optimization is based to have no explicit dependency on the water component 35 and the fat component 36. It is accordingly possible for the equation on which the second numerical optimization is based has no explicit dependency on the water component 35 and the fat component 36. For example, this explicit dependency can be eliminated a variable projection in relation to the water component 35 and the fat component 36, based on the spectral model or, respectively, Equation (5). Such a variable projection is in principle possible independent of whether the weightings W, F of the water component 35 and the fat component 36 are assumed to be complex-valued or real values. For example, it is possible for the equation on which the first numerical optimization is based to be described by a variable projection of complex-valued weightings W, F of the water component 35 and the fat component 36. This variable projection under the assumption of complex-valued weightings W, F is explained in the following.
(44) Equation (5) is sesquilinear in v(x). The parameters included in v(x) can be determined as a function of φ and A. The minimum of Equation (5) results at
v(x)=(A.sup.TA).sup.−1A.sup.Tφ.sup.TD(x) (6)
(45) Insertion of Equation (6) into Equation (5) yields:
(46)
wherein
PP.sup.T=A(A.sup.TA).sup.−1A.sup.T (8)
(47) The matrix defined by Equation (8) is a 2nd order positive Hermitian matrix with eigenvalues equal to 1. This means that this matrix according to Equation (8) is a projector and is the reason why the applied techniques are called “variable projection” techniques herein. The matrix P is not unique; the two columns merely need to form an orthonormal basis of the image of A. A possible selection is P=U, wherein U is part of the singular value decomposition A=UΣV.sup.T. In the following, it applies that: P=(p.sub.1,p.sub.2).
(48) It is also possible that the equation on which the first numerical optimization is based has no explicit dependency on the second phase φ.sub.EC(x). This is possible because the optimization of the second phase φ.sub.EC can also be addressed analytically. For this purpose, the MR signals are divided up into even MR signals (for which it applies that α.sub.E=1) and odd signals (for which it applies that α.sub.E=−1). With this differentiation it is obtained:
(49)
where Ψ.sup.e=e.sup.iΩTe has been inserted. This notation of Equation (9) can be simplified. For this, the MR signals are rearranged such that the continuous index e initially includes even MR signals and then includes odd MR signals. In this regard it can be written
(50)
wherein E designates even MR signals and O designates odd MR signals. The matrix M is Hermitian and can respectively be calculated once for each grid point 40 of the computation grid. In this notation,
(51)
is obtained.
(52) Equation (11) is minimized for e.sup.2iφEc=(Ψ.sub.E.sup.TOΨ.sub.O)*/|Ψ.sub.E.sup.TOΨ.sub.O|. Therefore, the following equation can be solved within the scope of the first numerical optimization:
(53)
This equation has no explicit dependency on the second phase φ.sub.EC(x). This Equation (12) also has no explicit dependency on the weightings W, F of the water component 35 and the fat component 36.
(54) The first phase Ω(x) can be determined by implementing the numerical optimization based on Equation (12). For example, the first numerical optimization can provide multiple result candidates for an image point 30. Particularly in such a case, the implementation of the first numerical optimization can furthermore include the implementation of a region growing technique. This is depicted in
(55) In
(56) In the preceding, techniques have predominantly been described in relation to the implementation of the first numerical optimization. It is directly possible to also apply corresponding techniques in relation to the determination of the second phase φ.sub.EC(x).
(57) For example, based on Equation (5) a simultaneous numerical optimization could be implemented both with regard to the first phase Ω(x) and with regard to the second phase φ.sub.EC(x). It would also be possible to computationally eliminate the first phase Ω(x) based on Equation (5), and therefore to obtain an equation (analogous to Equation (12)) that has no explicit dependency on the first phase Ω(x). This equation could then be solved within the scope of the numerical optimization to determine the second phase φ.sub.EC(x).
(58) However, a particularly simple and precise determination of the water content 35 and the fat content 36 can take place within the scope of the two-stage approach described in the preceding, in which initially the first phase Ω(x) is determined in the first numerical optimization and subsequently the second phase φ.sub.EC(x) is determined within the scope of the second numerical optimization. In such a case, the equation on which the second numerical optimization is based can in particular have neither an implicit nor an explicit dependency on the first phase Ω(x). This is the case because the influence of the field inhomogeneities that are described by the first phase can be computationally eliminated from the MR data before the implementation of the second numerical optimization; a cleaning of the MR data is thus possible.
(59) The equation on which the second numerical optimization is based can also have no implicit dependency on the water component 35 and the fat component 36. In particular, the weightings W, F of the water component 35 and the fat component 36 can be assumed to have real values.
(60) The equation on which the second numerical optimization is based can then be described by a variable projection of the real-valued weightings W, F of both spectral portions 35, 36. This is presented in the following. Starting from Equation (4), the following equation can similarly be taken into account under the assumption that v(x) is real-valued.
x.sup.2=∥Av−φ.sup.TD∥.sup.2, (13)
(61) This Equation (13) is bilinear in the water component and fat component. Therefore, the water component and the fat component can be eliminated. This is designated as the variable projection. For this purpose, the matrix A=A.sub.R+iA.sub.I can be split into the real part and imaginary part, wherein A.sub.R=(A) and A.sub.I=
(A). This yields
(62)
From this is obtained:
(63)
(64) The matrix B.sub.R is real-valued, symmetrical, and has an order of 2 with eigenvalues 1, i.e. represents a projection onto the space that is spanned by the columns (A.sub.R, A.sub.I).sup.T. Therefore, it can be written: B.sub.R=Σj=.sub.1,2{tilde over (w)}.sub.j{tilde over (w)}.sub.j.sup.T, wherein the vectors {tilde over (w)}.sub.j=(w.sub.Rj, w.sub.ij).sup.T have real values and are orthogonal to one another. With the definition of u.sub.j=w.sub.Rj+w.sub.ij,
(65)
is obtained.
(66) Using a comparison of Equations (7) and (16), the difference can be indicated between an approach in which the weightings W, F of the water component 35 and the fat component 36 are assumed as real-valued or, respectively, complex-valued. In Equation (7), it is not necessary to determine the real part (see Equation (16)), and the eigenvectors u.sub.j can be different depending on the imaginary part A.sub.i.
(67) Typically either the first phase Ω(x) or the second phase φ.sub.EC(x) can be eliminated in the approach described above, which is based on the assumption of real-valued weightings such as W, F of the water component 25 and the fat component 36. Moreover, the phase φ at the first echo time is to be considered in order to also take into account relative phase shifts between the water portion 35 and the fat portion 36 after the excitation.
(68) The preceding techniques form the basis of the subsequently described realizations: the determination of the first phase Ω(x) is typically predominantly independent of influences of the exposures, in particular if an approach according to Equation (12) is selected. On the other hand, the second phase φ.sub.EC(x)—which is obtained by the approach according to Equation (12)—often cannot be loaded (or can be loaded only to a limited extent), i.e. has large uncertainties. Therefore, within the scope of the implementation of the first optimization it can be worthwhile to take into account complex-valued weightings W, F for the water component 35 and the fat component 36 together with an equation that has no explicit dependency on the second phase φ.sub.EC(x) while, within the scope of the implementation of the second optimization, an equation is considered that assumes real values of weightings W, F of the water component 35 and the fat component 36 and that has no implicit and no explicit dependency on the first phase Ω(x).
(69) The realization described above—that the determination of the first phase Ω(x) has no or only a slight dependency on the second phase φ.sub.EC(x)—can be motivated based on the fact that the phases of the water component 35 and of the fat component 36 are not aligned for a scenario in which the water component 35 and the fat component 36 have a comparable order of magnitude—this can have strong influences on the determination of the second phase φ.sub.EC(x) due to eddy current effects in an approach with complex-valued weightings W, F of the water component 35 and the fat component 36 according to Equation (7).
(70) Based on this realization, Equation (16) can be reformulated to the effect that the first phase Ω(x) is assumed as given—namely according to the preceding determination—and only an optimization with regard to the second phase φ.sub.EC(x) is implemented. In this case,
(71)
is obtained.
(72) After optimization in the phase φ at the echo time 21,
(73)
is obtained. This equation has no explicit dependency on the phase φ of the first echo time 21 and on the weightings W, F of the water component 35 and fat component 36. Equation (18) can serve as a basis of the second numerical optimization. The second numerical optimization can in turn provide multiple result candidates for an image point 30 of the MR data 25. The implementation of the second optimization can furthermore include the implementation of a region growing technique for the multiple image points 30 of the MR data, with a value from the multiple result candidates for each image point 30 being selected as a result.
(74) The implementation of the first and second numerical optimization to determine the first phase and the second phase has been described in the preceding. The first phase Ω(x) and the second phase φ.sub.EC(x) can therefore be determined. After the first phase and the second phase φ.sub.EC(x) are determined, a field map of the field inhomogeneities and/or a field map of the eddy current effects can thus be provided to a user. The MR data 25 can be cleaned of the influence of the first phase Ω(x) before the implementation of the second numerical optimization to determine the second phase φ.sub.EC(x). Alternatively, it is also possible for the previously determined first phase Ω(x) to be treated as an input parameter in the implementation of the second numerical optimization. It is also possible (as noted above) to initially implement the second numerical optimization to determine the second phase φ.sub.EC(x), for example by the equation taken into account in having no explicit dependency on the first phase Ω(x), for example as is the case in Equation (17). The influence of the second phase φ.sub.EC(x) on the MR data 25 can accordingly subsequently be purged, or the second phase φ.sub.EC(x) could be treated as an input parameter in the implementation of the first numerical optimization to determine the first phase Ω(x).
(75) In general, it is possible to assume the relaxation rate R*.sub.2,water of the water component 35 and the relaxation rate R*.sub.2,fat of the fat component 36 are zero within the scope of the first numerical optimization and/or within the scope of the second numerical optimization. The first and second numerical optimizations thus can be implemented without additional consideration of the relaxation rates, which simplifies the determination.
(76) After the first phase Ω(x) and the second phase φ.sub.EC(x) have been determined, their influences on the MR data 25 can be compensated and it can subsequently be assumed that: Ω(x)=1 and φ(x)=1. The relaxation constants of the water component 35 and of the fat component 36 can subsequently be calculated, based on:
(77)
where only PP.sup.T is dependent on the relaxation constants. It is then possible to consider Equation (19) within the scope of the implementation of a numerical optimization which determines the relaxation rates of the water component (35) and fat component (36). An analytical calculation of the water component 35 and of the fat component 36 can subsequent take place under consideration of the previously determined relaxation rates.
(78) In the preceding case described with regard to Equation (19), the equation on which the numerical optimization to determine the relaxation rates is based has no dependency on the first phase Ω(x) and/or on the second phase φ.sub.EC(x). The dependency on the first phase Ω(x) and on the second phase φ.sub.EC(x) was eliminated by the preceding numerical determination of the first phase Ω(x) and the second phase φ.sub.EC(x) and purging of the influence of the first phase Ω(x) and the second phase φ.sub.EC(x) on the MR data 25.
(79) In the scenario described in the preceding, in which the numerical optimization to determine the relaxation rates is based on Equation (19), this also has no explicit dependencies on the water component 35 and the fat component 36. The explicit dependencies on the water component 35 and the fat component 36 were eliminated by a variable projection of the weightings W, F of the water component 35 and the fat component 36.
(80) In addition to an evaluation of Equation (19) described in the preceding to determine the relaxation rates, a derivative can also be of interest:
(81)
wherein R is a real-value variable. For the case of Equation (20), a relatively simple selection of P and its derivative dP/dR is shown. In Equation (20a), an orthonormal basis of image space of A is obtained by Gram-Schmidt orthonormalization and the corresponding derivatives
(82)
(83) In this way, the base and its derivative can be calculated on a grid, and the best local minimum can be determined depending on these. The physical relevant solution can therefore be selected from a number of result candidates that supplies the numerical optimization to determine the relaxation rates of the water component 35 and fat component 36.
(84) For example, the water component 35 and fat component 36 can also be calculated analytically based on Equation (21), or by a variable back-projection.
(85) For example, given known values of the relaxation rates the water component 35 and fat component 36 for complex-valued weightings W, F can be calculated via
v(x)=(A(A.sup.TA).sup.−1A.sup.TD(x) (22)
(86) For real-value weightings W, F of the water component 35 and fat component 36,
v(x)=((A.sup.TA))).sup.−1
(A.sup.TD(x)) (23)
is obtained. The fat component then results as:
(87)
(88) Since only the magnitude of the complete expression is taken instead of determining the magnitudes separately for the weightings W and F, a particularly good signal-to-noise ratio can be obtained.
(89) A flowchart of a method according to various aspects of the present invention is shown in
(90) The determination of the at least two spectral components and the first phase Ω(x) and the second phase φ.sub.EC(x) subsequently takes place in Step S3. The determination in Step S3 takes place numerically at least in part, for example in that one or more numerical optimizations are implemented. However, the determination within the scope of step S2 can also have analytical calculation steps.
(91) For example, in a particularly simple embodiment the Equation (4) or Equation (5) described in the preceding can take place within the scope of a single numerical optimization to determine the water component 35, the fat component 36, the first phase Ω(x) and the second phase φ.sub.EC(x). Within the scope of step S3 it is also possible to implement multiple steps in which individual instances of these variables cited in the preceding are respectively determined separately.
(92) The provision of a respective MR image for the at least two spectral components 35, 36 subsequently takes place in step S4 (optional step). Alternatively or additionally, a field map of the field inhomogeneities is shown based on the determined first phase Ω(x). Alternatively or additionally, it is possible that a field map of the eddy current effects is provided based on the determined second phase φ.sub.EC(x). The method ends in step S5.
(93) In
(94) The implementation of the first numerical optimization which determines the first phase Ω(x) based on field inhomogeneities initially takes place in Step T1. Step T1 is based on an equation that has no explicit dependency on the at least two spectral components 35, 36 and also has no explicit dependency on the second phase Ω(x), φ.sub.EC(x). The numerical optimization can thus be implemented in step T1, for example on the basis of Equation (12).
(95) The cleaning of the MR data 25 of influences of the first phase Ω(x) can subsequently take place in Step T2 (optional step). After the implementation of Step T2, the acquired MR data have no or only a small implicit and explicit dependency on the first phase Ω(x). This means that influences of the field inhomogeneities of the basic magnetic field on the MR data 25 are suppressed.
(96) The implementation of the second numerical optimization which determines the second phase φ.sub.EC(x) subsequently takes place in Step T3. The implementation of the second numerical optimization is based on an equation that has no explicit dependency on the at least two spectral components 35, 36 and also has no dependency on the first phase Ω(x). For example, Step T3 can be based on Equation (18).
(97) The equation on which the implementation of the second numerical optimization in Step T3 is based can take place by a variable projection with regard to the real-value, assumed weightings W, F of the water component 35 and of the fat component 36. In one case in which the weightings W, F are assumed to have real values, the phase φ at the first echo time 21 can additionally be taken into account. The equation on which the numerical optimization in Step T3 is based may have no explicit dependency on the phase φ at the first echo time 21. For example, this can be achieved by computational elimination of the phase φ at the first echo time from the equation that is obtained using the variable projection based on the spectral model (see Equations (17) and (18)).
(98) The purging of the acquired MR data 25 of influences of the second phase φ.sub.EC(x) subsequently takes place in Step T4. Steps T4 and T2 can have corresponding techniques.
(99) The implementation of the numerical optimization to determine the relaxation rates of the at least two spectral components 35, 36 takes place in Step T5. The equation on which the numerical optimization of Step T5 is based can in turn have no explicit dependency on the at least two spectral components 35, 36. For example, the explicit dependency can in turn be eliminated by variable projection based on the spectral model, for example under the assumption of real-value weightings W, F of the water component 35 and of the fat component 36. For example, Step T5 can be implemented with Equation (19).
(100) The analytical determination of the at least two spectral components takes place in Step T6.
(101) The features of the embodiments and aspects of the invention described in the preceding can naturally be combined with one another. In particular, the features can be used not only in the described combinations but also in other combinations or independently, without departing from the scope of the invention.
(102) Although modifications and changes may be suggested by those skilled in the art, it is the intention of the inventors to embody within the patent warranted hereon all changes and modifications as reasonably and properly come within the scope of their contribution to the art.