ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Abstract

An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. The assembly is configured such that, in a first portion of the thread, the nut member includes a first position with respect to an axis transversal to the rotational axis and in a second portion of the thread, the nut member includes a second position with respect to the axis transversal to the rotational axis. The nut member is configured to perform a tilting movement from the first position into the second position when the nut member passes from the first portion to the second portion. Furthermore, a drug delivery device comprising the assembly is described.

Claims

1. An assembly for a drug delivery device (1) comprising: a screw member (23) comprising a thread (33), the thread (33) comprising at least two consecutive portions (23a, 23b), the portions (23a, 23b) having different leads, a nut member (22), wherein the nut member (22) and the screw member (23) are adapted and arranged to be rotated with respect to one another about a rotational axis (34) during a dose setting operation of the assembly, the nut member (22) thereby being axially displaced along the screw member (23) from a start position to an end position with respect to the screw member (23) due to mechanical cooperation of the nut member (22) with the thread (33), and wherein the assembly is configured such that the nut member (22) performs a tilting movement when the nut member (22) passes from being engaged with a first portion (23a) of the thread to being engaged with the second portion (23b) of the thread (33).

2. The assembly according to claim 1, comprising a distal end (1a) and a proximal end (1b), wherein the first portion (23a) of the thread (33) is arranged closer to the distal end (1a) than the second portion (23b), wherein the lead of the first portion (23a) is less than the lead of the second portion (23b).

3. The assembly according to any of the previous claims, further comprising a housing (9), an inner housing sleeve (10) arranged within the housing (9), the inner housing sleeve (10) comprising at least one first splining member (40), wherein the nut member (22) comprises at least one second splining member (24), and wherein the nut member (22) is splined to the inner housing sleeve (10) due to mechanical cooperation of the splining members (24, 40).

4. The assembly according to claim 3, wherein the splined connection between the inner housing sleeve (10) and the nut member (22) is relieved for enabling the tilting movement from the first position into the second position when the nut member (22) passes from the first portion (23a) to the second portion (23b).

5. The assembly according to claim 3 or claim 4, wherein the second splining member (24) comprises an outer shape having a first part (28) and a second part (29) wherein the first part (28) is inclined relative to the second part (29).

6. The assembly according to claim 5, wherein the second part (29) is relieved from the first splining member (40) when the nut member (22) is engaged with the first portion (23a), and wherein the second part (29) is oblique with respect to the rotational axis (34) when the nut member (22) is engaged with the first portion (23a).

7. The assembly according to claim 6, wherein, the second part (29) is more oblique relative to the rotational axis (34) when the nut member (22) is engaged with the first portion (23a) of the thread (33) than it is when the nut member (22) is engaged with the second portion (23b) of the thread (33).

8. The assembly according to any of the previous claims, further comprising a cartridge (6) containing a plurality of doses of a drug and a dosing mechanism (4) operable for setting and delivering a dose of the drug from the cartridge (6), the dosing mechanism (4) comprising a last dose stop mechanism (16, 18) adapted and arranged to prevent a user from setting a dose of the drug which exceeds a remaining amount of drug in the cartridge (6), the last dose stop mechanism (16, 18) comprising at least one stop feature (16) provided by the screw member (33) and at least one interaction feature (18) provided by the nut member (22), wherein the stop feature (16) and the interaction feature (18) are configured to mechanically cooperate with one another when the nut member (22) is in the end position with respect to the screw member (23) such that further relative rotation of the nut member (22) and the screw member (23) for axially displacing the nut member (22) away from the start position is prevented.

9. The assembly according to any of the previous claims, wherein the nut member (22) comprises at least one interface feature (26) which is adapted and arranged to mechanically cooperate with the thread (33), and wherein the interface feature (26) comprises at least a partial turn of a thread.

10. The assembly according to claim 9, wherein the lead of the interface feature (26) is equal to the lead of the second portion (23b).

11. The assembly according to claim 9 or claim 10, wherein the interface feature (26) comprises a distal face (36) and a proximal face (37), the respective faces (36, 37) being configured to mechanically cooperate with a distal and a proximal wall (38, 39) of a winding of the thread (33) and wherein, when the nut member (22) mechanically cooperates with the second portion (23b), the distal and proximal faces (36, 37) are configured to have a greater contact area with the distal and proximal wall (38, 39) of a winding of the second portion (23b) compared to the contact area of the distal and proximal faces (36, 37) with the distal and proximal wall (38, 39) of a winding of the first portion (23a) when the nut member (22) mechanically cooperates with the first portion (23a).

12. The assembly according to any of claims 9 to 11, wherein, in at least one of the portions (23a, 23b) of the thread (33), the interface feature (26) mechanically cooperates with the thread (33) via distinct and separated contact points (27).

13. The assembly according to any of the previous claims, further comprising a housing (9) and an inner housing sleeve (10), wherein, during a dose setting operation, i) the screw member (23) is rotated with respect to the nut member (22) and to the inner housing sleeve (10), the inner housing sleeve (10) being prevented from rotation due to mechanical cooperation with the housing (9) and the nut member (22) being prevented from rotation due to mechanical cooperation with the inner housing sleeve (10), or ii) the inner housing sleeve (10) and the nut member (22) are rotated with respect to the screw member (23), the screw member (33) being prevented from rotation due to mechanical cooperation with the housing (9), wherein the nut member (22) is rotated due to mechanical cooperation with the inner housing sleeve (10).

14. The assembly according to any of the previous claims, further comprising a housing (9) and an inner housing sleeve (10), wherein, during a dose delivery operation, i) each of the screw member (23), the inner housing sleeve (10) and the nut member (22) is prevented from rotation with respect to the housing (9) such that the nut member (22) is prevented from axial movement with respect to the screw member (23); or ii) the screw member (23) and the inner housing sleeve (10) rotate together with respect to the housing (9) due to mechanical cooperation with one another such that the nut member (22) is prevented from axial movement with respect to the screw member (23).

15. A drug delivery device (1) comprising the assembly according to any of the previous claims.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0059] Further features and refinements become apparent from the following description of the exemplary embodiments in connection with the accompanying figures.

[0060] FIG. 1 schematically shows a side view of a drug delivery device,

[0061] FIG. 2 schematically shows a side view of parts of the drug delivery device of FIG. 1,

[0062] FIG. 3 schematically shows an exploded view of parts of the drug delivery device of FIG. 1,

[0063] FIG. 4 schematically shows a side view of a part of the drug delivery device of FIG. 1,

[0064] FIG. 5 schematically shows a side view of a part of the drug delivery device of FIG. 1,

[0065] FIGS. 6a and 6b schematically show a side view of a part of the drug delivery device of FIG. 1,

[0066] FIGS. 7a to 7d schematically show a partial section view of a part of the drug delivery device of FIG. 1.

[0067] Like elements, elements of the same kind and identically acting elements may be provided with the same reference numerals in the figures.

DETAILED DESCRIPTION

[0068] In FIGS. 1 and 2 a drug delivery device 1 is shown. The drug delivery device 1 comprises dosing mechanism 4. The dosing mechanism 4 comprises a housing 9. The drug delivery device 1 and the housing 9 have a distal end 1a and a proximal end 1b. The term “distal end” designates that end of the drug delivery device 1 or a component thereof which is or is to be arranged closest to a dispensing end of the drug delivery device 1. The term “proximal end” designates that end of the device 1 or a component thereof which is or is to be arranged furthest away from the dispensing end of the device 1. The distal end 1a and the proximal end 1b are spaced apart from one another in the direction of an axis. The axis may be the longitudinal axis or rotational axis 34 of the device 1.

[0069] The drug delivery device 1 comprises a cartridge retaining part 2. The cartridge retaining part 2 comprises a cartridge holder 5. The cartridge retaining part 2 comprises a cartridge 6. The cartridge 6 contains a drug, preferably a plurality of doses of the drug. The cartridge 6 is retained within the cartridge holder 5. The cartridge holder 5 stabilizes the position of the cartridge 6 mechanically. The cartridge holder 5 is connectable, e.g. by a threaded engagement, by a weld or by a snap-fit, to the housing 9. The cartridge holder 5 and the housing 9 may be releasably or irreleasably connected to one another.

[0070] A needle assembly (not explicitly shown) can be arranged at the distal end of the cartridge holder 5, e.g. by means of a thread 8. A cap 3 can be releasably secured to the drug delivery device 1 for protecting the device 1, and, in particular, the cartridge holder 5 or the cartridge 6 from environmental influences, e.g. when the device 1 is not used. A bung 7 is slideably retained within the cartridge 6. The bung 7 seals the cartridge 6 proximally. Movement of the bung 7 in the distal direction with respect to the cartridge 6 causes the drug to be dispensed from the cartridge 6.

[0071] The drug delivery device 1 may be a pen-type device, in particular a pen-type injector. The device 1 may be a re-usable device, which means that the cartridge 6 can be replaced, in particular during a reset operation, by a replacement cartridge for dispensing a plurality of doses from the replacement cartridge. Alternatively, the device 1 may be a disposable device 1 which means that the cartridge 6 is non-releasably connected to the cartridge holder 5.

[0072] The dosing mechanism 4 comprises a dose dial grip 12. For setting a dose of the drug, a user rotates the dose dial grip 12, which is described later on in detail.

[0073] FIGS. 3 to 7d schematically show parts of the drug delivery device 1. The dosing mechanism 4 comprises a screw member 23, a nut member 22 and an inner housing sleeve 10 (see FIG. 3).

[0074] The inner housing sleeve 10 comprises an insert of the housing 9. The inner housing sleeve 10 is secured against axial movement with respect to the housing 9 by mechanical cooperation with the housing 9. The inner housing sleeve 10 may be secured against rotational movement with respect to the housing 9 by mechanical cooperation with the housing 9, e.g. by a splined connection. Alternatively, the inner housing sleeve 10 may be rotatable with respect to the housing 9 at least for setting a dose. In particular, when the screw member 23 is rotatable with respect to the housing 9 during a dose setting operation, the inner housing sleeve 10 may be adapted to be non-rotatable with respect to the housing 9 during the dose setting operation and vice versa.

[0075] The nut member 22 is shaped like a half-sleeve. The nut member 22 may comprise a partial nut or half-nut (see FIGS. 3 and 5). The nut member 22 comprises an axial dimension smaller than the axial dimension of the inner housing sleeve 10. The nut member 22 is arranged within the inner housing sleeve 10. The nut member 22 is arranged at least partly around the screw member 23. As the nut member 22 is a half-nut, it is assembled onto the screw member 23 from the radial direction. Alternatively, the nut member 22 may be assembled axially in the proximal direction.

[0076] The nut member 22 is secured against rotation around the rotational axis 34 with respect to the inner housing sleeve 10 by mechanical cooperation with the inner housing sleeve 10. Preferably, the nut member 22 is splined to the inner housing sleeve 10. For this purpose, the inner housing sleeve 10 comprises a plurality of first splining members 40, e.g. grooves (see FIG. 3). The respective groove 40 extends along an inner surface of the inner housing sleeve 10. The nut member 22 comprises several second splining members 24, e.g. lugs or protrusions (see FIG. 5). The respective protrusion 24 is arranged on an outer surface of the nut member 22. The protrusion 24 protrudes from the nut member 22 in the radial outward direction. The protrusion 24 extends along the nut member 22. The protrusion 24 comprises a first part 28 and a second part 29 (see FIGS. 6a and 6b). Alternatively, the inner housing sleeve 10 may comprise protrusions and the nut member 22 may comprise grooves (not explicitly shown). The splined connection between the nut member 22 and the inner housing sleeve 10 can be relieved. In this way, the nut member 22 is, under certain circumstances, rotatable off the rotational axis 34 relative to the first splining member 40 and, thus, to the inner housing sleeve 10, which is explained later on in detail.

[0077] The nut member 22 and the screw member 23 are rotatable with respect to one another about the rotational axis 34 during a dose setting operation. The nut member 22 is axially moveable with respect to the inner housing sleeve 10 due to mechanical cooperation of the first and second splining member 24, 40.

[0078] The screw member 23 is arranged within the inner housing sleeve 10. The screw member 23 is arranged at least partly within the nut member 22. The screw member 23 may be formed sleeve-like. The screw member 23 may comprise a shaft at its distal end (not explicitly shown) for driving the bung 7 in the distal direction with respect to the housing 9. Alternatively, a separate part may push the bung. In particular, the assembly may comprise a piston rod (not shown) which is splined to the screw member 29 and threaded to the housing 9. The assembly may be configured such that when the screw member 23 rotates, the piston rod advances and, thereby, drives the bung in the distal direction.

[0079] The screw member 23 may be rotatable with respect to the housing 9. Alternatively, the screw member 23 may be prevented from rotation with respect to the housing 9, e.g. by means of a splined connection with the housing 9.

[0080] The dosing mechanism 4 further comprises a last dose stop mechanism which prevents a user from setting a dose of the drug which exceeds a remaining amount of drug in the cartridge 6. The last dose stop mechanism comprises a stop feature 16 (see FIG. 4). The stop feature 16 is provided by the screw member 23. The stop feature 16 is arranged in a proximal end portion of the screw member 23. The stop feature 16 may be an edge or a protrusion. The stop feature 16 may protrude from the screw member 23 in a radial direction. The last dose stop mechanism further comprises an interaction feature 18. The interaction feature 18 is provided by the nut member 22 (see FIG. 7c). The interaction feature 18 may comprise an edge or a protrusion protruding from the nut member 22 in a radial direction.

[0081] The stop feature 16 and the interaction feature 18 are configured to mechanically cooperate with one another when the nut member 22 is in an end position or proximal position with respect to the screw member 13 such that further relative rotation of the nut member 22 and the screw member 23 for axially displacing the nut member 22 away from the start position is prevented. Hence, mechanical cooperation of the stop feature 16 and the interaction feature 18 determines the end end position of the nut member 22 with respect to the screw member 23. The length of the axial travel of the nut member 22 on the screw member 23 corresponds to the maximum number of doses of the drug which can be dispensed from the device 1.

[0082] When the nut member 22 has reached the end position, a rotational abutment is created by means of mechanical cooperation of the stop feature 16 and the interaction feature 18, coupling the screw member 23 to the inner housing sleeve 10. Accordingly, in the end position, relative rotation between the screw member 23 and the inner housing sleeve 10 leading to axial movement of the nut member 22 in the proximal direction, is no longer possible. However, the nut member 22 may be enabled to travel in the distal direction back towards the start position, e.g. for a dose correction operation.

[0083] The screw member 23 comprises a helical thread 33 (see FIGS. 3 and 4). The thread 33 is arranged on an outer surface of the screw member 23. In an alternative design, the thread 33 may be arranged on an inner surface of the screw member 33. In this case, the screw member 23 may be arranged such that the inner housing sleeve is arranged inside the screw member 23.

[0084] The thread 33 comprises two consecutive portions, i.e. a first portion 23a and a second portion 23b. Alternatively, the thread 33 may comprise three or more consecutive portions (not explicitly shown). A transition region may be arranged between each of the consecutive portions wherein the transition region is significantly smaller than the respective portions.

[0085] The first portion 23a is arranged in a distal portion of the screw member 23. The second portion 23b is arranged more proximally than the first portion 23a. The first portion 23a has a greater axial dimension than the second portion 23b. The thread 33 has a variable lead. The lead of the first portion 23a is less than the lead of the second portion 23b. The first portion 23a is a slow thread and the second portion 23b is a fast thread. The ratio between slow and fast thread leads is 1:1.5, for example. The first portion 23a is single-start thread, the second portion 23b is a twin-start thread.

[0086] The nut member 22 mechanically cooperates with the screw member 23 and, in particular, with the thread 33 via one interface feature 26 (see FIG. 5). The interface feature 26 is arranged on an inner surface of the nut member 22. The interface feature 26 extends circumferentially along an outer surface of the nut member 22. The interface feature 26 comprises a partial turn of a thread. The lead of this partial turn is equal to the fast thread form of the screw member 23, i.e. it is equal to the lead of the second portion 23b. The specific shape of the interface fature 26 and increased clearances in the thread forms of the screw member 23 allow the nut member 22 to mesh with the different portions 23a, 23b without interference.

[0087] The splined engagement between the inner housing sleeve 10 and the nut member 22 and the mechanical cooperation of the interface feature 26 with the portions 23a, 23b enables a rocking movement of the nut member 22, i.e. a rotational movement off the rotational axis 34, as mentioned above when the nut member 22 travels towards the end position with respect to the screw member 23. For this purpose, the protrusion 24 comprises a rounded or angled outer shape, in particular an outer shape which is only in parts parallel to the rotational axis 34 when the nut member 22 is engaged with the screw member 23.

[0088] The second part 29 of the protrusion 24 is relieved from the inner housing sleeve 10 when the nut member 22 is engaged with the first portion 23a (see FIG. 6a). The second part 29 is oblique with respect to an axis 42 parallel to the rotational axis 34 when the nut member 22 is engaged with the first portion 23a. Accordingly, the nut member 22 is rotated anti-clockwise with respect to the inner housing sleeve 10 about an axis perpendicular to the rotational axis 34 when being engaged with the first portion 23a. Thus, when the nut member 22 is engaged with the first portion 23a, the nut member 22 is in a first position 44 with respect to an axis 43 perpendicular to the rotational axis 34 (see FIG. 7a). In other words, it encloses a first angle with the axis 43 perpendicular to the rotational axis 34. In particular, it is rotated anti-clockwise away from the axis 43 perpendicular to the rotational axis 34 (see FIG. 7a). The apparent lead is reduced when the nut member 22 is engaged with the first portion 23a as indicated by arrow 30 in FIG. 6a.

[0089] When the nut member 22 becomes engaged with the second portion 23b, the proximal portion 29 of the protrusion 24 becomes parallel with respect to the axis 42 (see FIG. 6b). Accordingly, the nut member 22 is rotatable clockwise off the rotational axis 34 with respect to the inner housing sleeve 10 when the nut member 22 passes into the second portion 23b. Thus, when the nut member 22 is engaged with the second portion 23b, the nut member 22 is in a second position 45 with respect to the axis 43 perpendicular to the rotational axis 34 (see FIG. 7c). In other words, it encloses a second angle with the axis 43 perpendicular to the rotational axis 34. In particular, it is rotated clockwise away from the axis 43 perpendicular to the rotational axis 34 during transition from the first portion 23a into the second portion 23b. The nut member 22 performs a tilting or rocking movement from the first position into the second position when the nut member 22 passes from the first portion 23a to the second portion 23b to accommodate the fast thread lead (see arrow 46 in FIG. 7b). When the nut member 22 is engaged with the fast thread, the half turn of the nut member 22 comprises a full fast thread lead as indicated by arrow 31 in FIG. 6b.

[0090] In the following, operation of the device 1 is described in detail:

[0091] After having assembled the device 1, the nut member 22 is positioned in a distal or start position with respect to the screw member 23 (not explicitly shown). In the start position, the nut member 22 mechanically cooperates with the first portion 23a as described above. Thus, in FIG. 7a, the interface feature 26 is engaged with a winding of the first portion 23a of the thread 33. The interface feature 26 comprises a distal face 36 and a proximal face 37 (see FIG. 5). The faces 36, 37 mechanically cooperate with a corresponding distal and proximal wall 38, 39 of a winding of the thread 33. When engaging the first portion 23a of the thread 33, the nut member 22 and, in particular, the interface feature 26, is in three-point contact with a winding of the first portion 23. This means, that the respective face 36, 37 mechanically cooperates via three distinct contact points 27 with the corresponding wall 38, 39 of the winding (see FIG. 5). The contact via the distinct contact points 27 occurs because the thread on the interface feature 26 does not match the thread 33 in the first portion 23a. To allow rotation even with a mismatched thread, clearance is increased.

[0092] For setting a dose, the dose dial grip is rotated 12. Rotation of the dose dial grip 12 is transferred into rotation of the screw member 23 due to mechanical cooperation with the dose dial grip 12 (not explicitly shown). The inner housing sleeve 10 is prevented from rotation due to the splined connection with the housing 9. Upon rotation of the screw member 23, the nut member 22 is axially displaced along the screw member 23 in the proximal direction from the distal position, i.e. the position in which the nut member 22 is located with respect to the screw member 23 after assembly of the device 1 was completed, to the previously mentioned proximal end position with respect to the screw member 23 due to mechanical cooperation of the nut member 22 with the thread 33.

[0093] Alternatively, for setting a dose, the dose dial grip is rotated 12. The inner housing sleeve 10 is rotated with respect to the screw member 23 due to mechanical cooperation with the dose dial grip 12 (not explicitly shown). In this case, the screw member 23 is prevented from rotation due to mechanical cooperation with the housing 9. The nut member 22 rotates together with the inner housing sleeve 10 due to the splined connection. Upon rotation of the inner housing sleeve 10 and the nut member 22, the nut member 22 is axially displaced along the screw member 23 in the proximal direction from the start position to the end position with respect to the screw member 23 due to mechanical cooperation of the nut member 11 with the thread 33.

[0094] In each embodiment, during a dose setting operation, the nut member 22 and the screw member 23 rotate with respect to one another.

[0095] According to one embodiment, during a dose delivery operation, the screw member 23, the inner housing sleeve 10 and the nut member 22 are prevented from rotation with respect to one another and with respect to the housing 9 such that the nut member 22 is prevented from axial movement with respect to the screw member 23. Rather, the screw member 23 and/or an associated shaft may move distally, thereby forcing the bung 7 in the distal direction with respect to the housing 9. In the alternative design wherein a piston rod is splined to the screw member 29 and threaded to the housing 9, the the piston rod is moved distally during the dose delivery operation, thereby forcing the bung 7 in the distal direction with respect to the housing 9.

[0096] Alternatively, for delivery of the dose, the screw member 23 and the inner housing sleeve 10 rotate together with respect to the housing 9 due to mechanical cooperation with one another. As the screw member 23 and the inner housing sleeve 10 rotate together at the same rate, no axial movement of the nut member 22 is generated. Rather, the screw member 23 may move distally, thereby forcing the bung 7 in the distal direction with respect to the housing 9. In an alternative design, the screw member 23 may move a piston rod distally, thereby forcing the bung 7 in the distal direction with respect to the housing 9.

[0097] When the nut member 22 moves towards the end position during subsequent dose setting operations, the nut member 22 mechanically cooperates with the different portions 23a, 23b of the thread 33. In particular, during subsequent dose setting operations, the nut member 22 moves proximally towards the end position (see arrow 32 in FIG. 7a), thereby entering a transition region 23c between the first portion 23a and the second portion 23b. While passing from the first portion 23a into the second portion 23b, the nut member 22 rotates clockwise to accommodate the increasing lead of the second portion 23b as shown in FIG. 7b.

[0098] When the nut member 22 engages the second portion 23b, the nut member 22 has completed its rocking movement and is arranged in the second position (see FIG. 7c). When engaging the second portion 23b, the contact area between distal and proximal faces 36, 37 and the corresponding wall 38, 39 of a winding of the second portion 23b is greater than when the nut member 22 engages the first portion 23a. In other words, when the nut member 22 transitions to the second portion 23b, the point contacts become a full face contact to minimise contact stresses when the last dose stop engages.

[0099] Upon further movement in the proximal direction, the nut member 22 reaches the end position with respect to the screw member 23, which is shown in FIG. 7d. In the end position, the interaction feature 18 of the nut member 22 mechanically cooperates with the stop feature 16 of the screw member as described above. Thus, further movement of the nut member 22 in the proximal direction is prevented. The last complete dose has been dispensed from the cartridge 6 and the cartridge 6 may be replaced by a replacement cartridge, for example.

[0100] Other implementations are within the scope of the following claims. Elements of different implementations may be combined to form implementations not specifically described herein.

REFERENCE NUMERALS

[0101] 1 Drug delivery device [0102] 1a Distal end [0103] 1b Proximal end [0104] 2 Cartridge retaining part [0105] 3 Cap [0106] 4 Dosing mechanism [0107] 5 Cartridge holder [0108] 6 Cartridge [0109] 7 Bung [0110] 8 Thread [0111] 9 Housing [0112] 10 Inner housing sleeve [0113] 12 Dose dial grip [0114] 16 Stop feature [0115] 18 Interaction feature [0116] 22 Nut member [0117] 23 Screw member [0118] 23a First portion [0119] 23b Second portion [0120] 23c Transition region [0121] 24 Second splining member/protrusion [0122] 26 Interface feature [0123] 27 Contact point [0124] 28 first part [0125] 29 second part [0126] 30 Arrow [0127] 31 Arrow [0128] 32 Arrow [0129] 33 Thread [0130] 34 Rotational axis [0131] 36 Distal face [0132] 37 Proximal face [0133] 38 Distal wall [0134] 39 Proximal wall [0135] 40 First splining member/groove [0136] 42 Axis [0137] 43 Axis [0138] 44 First position [0139] 45 Second position [0140] 46 Arrow