COMPOSITION COMPRISING A POLYSACCHARIDE, A POLYOL AND SPECIFIC ESTER AND OIL

Abstract

The present invention relates to a composition, preferably a cosmetic composition, comprising at least one polysaccharide comprising rhamnose: at least one polyol, at least one fatty acid and polyglycerol ester comprising 5 to 9 glycerol patterns, and at least 10% by weight of at least one non-volatile hydrocarbon oil relative to the total weight of the composition, chosen from among C.sub.10-C.sub.26 monoalcohols; monoesters with formula R.sub.1COOR.sub.2 wherein R.sub.2 represents the remainder of a saturated or unsaturated, linear or branched or aromatic fatty acid comprising 4 to 40 carbon atoms, and R.sub.2 represents a hydrocarbon Chain, particularly branched, containing 3 to 40 carbon atoms, provided that R.sub.1+R.sub.2 is greater than or equal to 17; the diesters comprising between 17 and 40 carbon atoms in total, and in particular diesters with formula R′.sub.1COOR′.sub.2OOCR′.sub.3 wherein R′.sub.1 and R′.sub.3 each represent the remainder of a linear N or branched fatty acid comprising from 4 to 15 carbon atoms, and R′.sub.2 represents a hydrocarbon chain, particularly linear, containing 2 to 10 carbon atoms; plant hydrocarbon oils; linear or branched alkanes having 15 to 19 carbon atoms; and mixtures thereof.

Claims

1. A composition comprising in a physiologically acceptable medium: at least one polysaccharide containing rhamnose, at least one polyol, at least one ester of fatty acid and of polyglycerol comprising 5 to 9 glycerol patterns, and at least 10% by weight of at least one non-volatile hydrocarbon oil relative to the total weight of the composition, chosen from among C.sub.10-C.sub.26 monoalcohols; monoesters with the formula R.sub.1COOR.sub.2 wherein R.sub.1 represents the remainder of a saturated or unsaturated, linear or branched or aromatic fatty acid comprising 4 to 40 carbon atoms, and R.sub.2 represents a hydrocarbon chain containing 3 to 40 carbon atoms, provided that R.sub.1+R.sub.2 is greater than or equal to 17; the diesters comprising between 17 and 40 carbon atoms in total; plant hydrocarbon oils; linear or branched alkanes having 15 to 19 carbon atoms; and mixtures thereof.

2. The composition according to claim 1, wherein the polysaccharide comprises rhamnose amount varying from 10% to 100% by weight relative to the total weight of polysaccharide.

3. The composition according to claim 1, wherein the repetitive elements that form the polysaccharide comprise at least components with general formula I: ##STR00007## wherein Rh is a rhamnose molecule, Rh* is a rhamnose molecule fixed in a branched manner, O is a molecule of a hexosidic or pentosidic sugar, U is a molecule of uronic acid and n is between 1 and 100.

4. A composition according to claim 1, wherein the repetitive elements forming the polysaccharide are composed of the sequence with general formula II: ##STR00008## wherein Rh is a rhamnose molecule, O is a hexosidic or pentosidic sugar molecule, U is a uronic acid molecule and the rhamnose branch onto the ose O consists of an osidic bond (1.fwdarw.2) or (1.fwdarw.3).

5. The composition according to claim 1, wherein the repetitive elements forming the polysaccharide are composed of the sequence with general formula III: ##STR00009## wherein Rh is a rhamnose molecule, 0 is a hexosidic or pentosidic sugar molecule, U is a uronic acid molecule and rhamnose is branched onto the rhamnose by an osidic bond (1.fwdarw.3).

6. A composition according to claim 1, wherein the polysaccharide is a polymer with a branched structure, with a molecular weight of the order of 50 000 daltons, and having a saccharidic sequence comprising three molecules of rhamnose (I, III, VI), two molecules of galactose (II, V) and one molecule of glucuronic acid (IV), said sequence having the following formula: ##STR00010##

7. A composition according to claim 1, wherein the ester of fatty acid and of polyglycerol is formed from at least one acid comprising an alkyl or alkenyl chain containing from 12 to 20 carbon atoms and 5 to 9 glycerol patterns, preferably from 5 to 6 glycerol patterns.

8. A composition according to claim 1, wherein the ester of fatty acid and of polyglycerol is present in the composition according to the invention in a content ranging from 1% to 10% by weight relative to the total weight of the composition.

9. A composition according to claim 1 the polyol is chosen from among glycerine and its derivatives, and glycols and their derivatives, and mixtures thereof.

10. A composition according to claim 1 the polyol is present in a content ranging from 2% to 30% by weight, relative to the total weight of the composition.

11. A composition according to claim 1, wherein the oil is a fatty alcohol comprising 10 to 24 carbon atoms.

12. A composition according to claim 1, wherein the oil is octyldodecanol, present between 10% and 30% by weight of the total weight of the composition, preferably between 10% and 20% by weight.

13. A composition according to claim 1, wherein the oil is chosen from among Purcellin oil, isononyl isononanoate, C.sub.12 to C.sub.15 alcohol benzoate, 2-ethyl hexyl palmitate, octyldodecyl neopentanoate, octyl-2 dodecyl stearate, octyl-2-dodecyl erucate, isostearyl isostearate, octyl-2 dodecyl benzoate, octanoates, decanoates or ricinoleates of alcohols or of polyalcohols, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, 2-ethyl-hexyl palmitate, 2-hexyl-decyl laurate, 2-octyl-decyl palmitate and 2-octyldodecyl myristate.

14. A composition according to claim 1, wherein the oil is isononyl isononanoate; and/or isopropyl myristate.

15. A composition according to claim 1, wherein the oil is 1,3-propanediol dicaprylate.

16. A composition according to claim 1, wherein the oil is a plant hydrocarbon oil.

17. A composition according to claim 1, wherein the oil is a mixture of alkanes.

18. A composition according to claim 1, wherein it comprises at least one surfactant that is a fatty acid and polyethylene glycol ester.

19. A composition according to claim 1, which comprises at least one hydrophilic active agent. ##STR00011##

20. A cosmetic method for cleansing keratin materials comprising the application of a composition according to claim 1 onto said keratin materials.

21. A cosmetic method for making the skin more supple, particularly the stratum corneum, comprising applying a composition according to claim 1 onto the skin.

22. A composition comprising, in a physiologically acceptable medium: at least one polysaccharide comprising rhamnose, at least at least one hydrophilic active agent, ##STR00012## and optionally at least 10% by weight relative to the total weight of composition, of at least one non-volatile hydrocarbon oil chosen from among: C.sub.10-C.sub.26 monoalcohols, monoesters with formula R.sub.1COOR.sub.2 wherein R.sub.1 is the remainder of a linear or branched or aromatic fatty acid comprising from 4 to 40 saturated or unsaturated carbon atoms and R.sub.2 is a hydrocarbon chain, with the condition that R.sub.1+R.sub.2 is greater than or equal to 17; diesters comprising between 17 and 40 carbon atoms in total, vegetable hydrocarbon oils; linear or branched alkanes having from 15 to 19 carbon atoms; and mixtures thereof.

Description

EXAMPLES

[0201] In all the examples, the compositions were prepared with the ingredients mentioned in the following table, using the protocol described below:

The ingredients of phase B are mixed and heated to 80 C;
The ingredients of phase A are mixed and heated to 80 C;
Under Rayneri stirring, phase B is poured slowly into phase A;
Phase C is added at about 50° C.

[0202] Furthermore, in the examples, the protocol when tackiness on drying is measured is as follows:

[0203] Evaluation of Tackiness

[0204] The degree of tackiness when drying is evaluated in vivo: [0205] 50 microliters of formula are deposited on the back of the hand and applied by a circular movement at one turn per second until penetration; [0206] the tackiness is then evaluated by touching the deposit with 2 fingers.

[0207] A score is assigned to the tackiness, that varies from 1 (not tacky) to 5 (very tacky).

[0208] A score strictly less than 2 is considered to be only slightly tacky and cosmetically acceptable.

Example 1: Preparation of a Comparative Reference Composition

[0209] The comparative reference composition is prepared with the ingredients mentioned in the following table, using the protocol described above.

TABLE-US-00001 TABLE 1 Formula (% w/w) Phase Ingredient (comparative) C SODIUM HYDROXIDE 0.07 A POLYSACCHARIDE 5 (INCI name: biosaccharide gum-2) (Rhamnosoft HP 1.5P by Solabia) A Preservative Qs B CETYL ALCOHOL 1 B STEARYL ALCOHOL 1 B HYDROGENATED ISOPARAFFIN (6-8 6 MOLES OF ISOBUTYLENE) C CARBOXYVINYLIC POLYMER 0.25 SYNTHETIZED IN THE ETHYL ACETATE/CYCLOHEXANE MIXTURE (carbomer) B CYCLOHEXA DIMETHYLSILOXANE 4 (VISCOSITY: 8 CST) A WATER Qs 100 A GLYCERINE 10 B GLYCERYL MONO/DISTEARATE/ 2.5 POLYETHYLENE GLYCOL STEARATE MIXTURE (100 OE) (INCI name: GLYCERYL STEARATE (and) PEG-100 STEARATE) (Arlacel 165 by Croda) B POLYETHYLENE GLYCOL STEARATE 2.5 (40 OE) (Myrj 52P by Croda) B POLYGLYCERYL-5 LAURATE 5 (SUNSOFT A-121E-C ® by Taiyo Kagaku) Tackiness when drying 3.5

[0210] This comparative composition has a tackiness when drying equal to 3.5.

Example 2: Preparation of Comparative Compositions (F1 to F3) and a Composition According to the Invention (F4)

[0211] The following compositions F1 to F4 were prepared with the ingredients mentioned in the following table, using the protocol described above:

TABLE-US-00002 TABLE 2 F1 F2 F3 F4 (comparative) (comparative) (comparative) (invention) Phase Ingredient (% w/w) (% w/w) (% w/w) (% w/w) A POLYSACCHARIDE 5 5 5 5 (INCI name: biosaccharide gum-2) (Rhamnosoft HP 1.5P by Solabia) A Preservative Qs Qs Qs Qs B 2-OCTYLDODECAN-1-OL 2 5 7 15 A WATER Qs 100 Qs 100 Qs 100 Qs 100 A GLYCERINE 10 10 10 10 B GLYCERYL 1 1 1 1 MONO/DISTEARATE/ POLYETHYLENE GLYCOL STEARATE MIXTURE (100 OE) (INCI name: GLYCERYL STEARATE (and) PEG-100 STEARATE) (Arlacel 165 by Croda) B POLYETHYLENE 1 1 1 1 GLYCOL STEARATE (40 OE) (Myrj 52P by Croda) B POLYGLYCERYL-5 5 5 5 5 LAURATE (SUNSOFT A-121E- C ® by Taiyo Kagaku) Tackiness when 4 2 2 1.5 drying

[0212] The results show that only formula F4 according to the invention, i.e. having at least 5% of octyldodecanol, has much lower tackiness than comparative formulas F1 to F3; but also than the comparative reference composition in example 1.

Example 3: Preparation of Compositions According to the Invention (C1 to C3)

[0213] The following compositions C1 to C3 were prepared with the ingredients mentioned in the following table, using the protocol described above:

TABLE-US-00003 TABLE 3 C1 C2 C3 Phase Ingredient (% w/w) (% w/w) (% w/w) A POLYSACCHARIDE 5 5 5 (INCI name: biosacchande gum-2) (Rhamnosoft HP 1.5P by Solabia) C AMORPHOUS SILICA 2 2 2 MICROSPHERES (5 μm) A Preservative Qs Qs Qs B ISOPROPYL MYRISTATE 5 B REFINE DEODORIZED 2 STABILIZED SHEA BUTTER B ISONONYL ISONONANOATE 5 5 B 1,3 PROPANEDIOL DICAPRYLATE 5 5 5 B ACRYLAMIDO-2-METHYL 0.4 0.4 0.4 PROPANE SODIUM SULFONATE/HYDROXY- ETHYL ACRYLATE COPOLYMER (INCI: HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER); (SEPINOV EMT 10 by Seppic) B AMPS/ETHOXYLATED STEARYL 0.7 0.7 0.7 METHACRYLATE (25 EO) COPOLYMER CROSS-LINKED BY TRIMETHYLOLPROPANE TRIACRYLATE (INCI: AMMONIUM ACRYLOYLDI- METHYLTAURATE/ STEARETH-25 METHACRYLATE CROSSPOLYMER) (ARISTOFLEX HMS by Clariant) A Ethanol 3 3 3 A WATER Qs 100 Qs 100 Qs 100 A GLYCERINE 10 10 10 B GLYCERYL MONO/DISTEARATE/ 1 1 1 POLYETHYLENE GLYCOL STEARATE MIXTURE (100 OE) (INCI name: GLYCERYL STEARATE (and) PEG-100 STEARATE) (Arlacel 165 by Croda) B POLYETHYLENE GLYCOL 1 1 1 STEARATE (40 OE) (Myrj 52P by Croda) B POLYGLYCERYL-5 5 5 5 LAURATE (SUNSOFT A-121E- C ® by Taiyo Kagaku) Tackiness when drying 1.5 1.5 1.5

[0214] The results show that the formulas C1 to C3 according to the invention, i.e. comprising at least 10% of oils chosen from among isopropyl myristate, shea butter, isononyl isononanoate and propanediol dicaprylate, have low tackiness when drying.

Example 4: Preparation of Compositions According to the Invention (C4 to C9)

[0215] The following compositions C4 to C9 according to the invention were prepared with the ingredients mentioned in the following table, using the protocol described above:

TABLE-US-00004 TABLE 4 C4 C5 C6 C7 C8 C9 Ingredient (% p/p) (% p/p) (% p/p) (% p/p) (% p/p) (% p/p) POLYSACCHARIDE 5 5 5 5 5 5 (INCI name: biosaccharide gum-2) (Rhamnosoft HP 1.5P by Solabia) AMORPHOUS SILICA 2 2 2 2 2 2 MICROSPHERES (5 μm) Preservative Qs Qs Qs Qs Qs Qs ISOPROPYL MYRISTATE 20 2-OCTYLDODECAN-1-OL 10 ISONONYL ISONONANOATE 10 20 30 1,3 PROPANEDIOL DICAPRYLATE 10 ACRYLAMIDO-2-METHYL 0.4 0.4 0.4 0.4 0.4 0.4 PROPANE SODIUM SULFONATE/ HYDROXYETHYL ACRYLATE COPOLYMER (INCI: HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER); (SEPINOV EMT 10 by Seppic) AMPS/ETHOXYLATED 0.7 0.7 0.7 0.7 0.7 0.7 STEARYL METHACRYLATE (25 EO) COPOLYMER CROSS-LINKED BY TRIMETHYLOLPROPANE TRIACRYLATE (INCI: AMMONIUM ACRYLOYLDIMETHYLTAURATE/ STEARETH-25 METHACRYLATE CROSSPOLYMER) (ARISTOFLEX HMS by Clariant) Ethanol 3 3 3 3 3 3 WATER Qs 100 Qs 100 Qs 100 Qs 100 Qs 100 Qs 100 GLYCERINE 10 10 10 10 10 10 GLYCERYL MONO/DISTEARATE/ 1 1 1 1 1 1 POLYETHYLENE GLYCOL STEARATE MIXTURE (100 OE) (INCI name: GLYCERYL STEARATE (and) PEG-100 STEARATE) (Arlacel 165 by Croda) POLYETHYLENE GLYCOL 1 1 1 1 1 1 STEARATE (40 OE) (Myrj 52P by Croda) POLYGLYCERYL-5 LAURATE 5 5 5 5 5 5 (SUNSOFT A-121E-C ® by Taiyo Kagaku) Tackiness when drying 1 1 1.5 1.5 1 1.5

[0216] The results show that the formulas C4 to C9 according to the invention, i.e. comprising at least 10% of oils chosen from among isopropyl myristate, octyldodecanol, isononyl isononanoate and propanediol dicaprylate, have low tackiness when drying.

Example 5: Preparation of Compositions According to the Invention (C10 to C14)

[0217] The following compositions 010 to C14 according to the invention were prepared with the ingredients mentioned in the following table, using the protocol described above:

TABLE-US-00005 TABLE 5 C10 C11 C12 C13 C14 (% (% (% (% (% Ingredient w/w) w/w) w/w) w/w) w/w) POLYSACCHARIDE 5 5 5 5 5 (INCI name: biosaccharide gum-2) (Rhamnosoft HP 1.5P by Solabia) AMORPHOUS SILICA MICROSPHERES (5 2 2 2 2 2 μm) Preservative Qs Qs Qs Qs Qs C15-C16 BRANCHED ALKANES 10 20 30 (Emogreen L15 by Seppic) C17-C18 BRANCHED ALKANES 10 (Emogreen L19 by Seppic) C15-C19 BRANCHED ALKANES 10 (Emosmart L19 by Seppic) ACRYLAMIDO-2-METHYL PROPANE 0.4 0.4 0.4 0.4 0.4 SODIUM SULFONATE/HYDROXYETHYL ACRYLATE COPOLYMER (INCI: HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER); (SEPINOV EMT 10 by Seppic) AMPS/ETHOXYLATED STEARYL 0.7 0.7 0.7 0.7 0.7 METHACRYLATE (25 EO) COPOLYMER CROSS-LINKED BY TRIMETHYLOLPROPANE TRIACRYLATE (INCI: AMMONIUM ACRYLOYLDIMETHYLTAURATE/ STEARETH-25 METHACRYLATE CROSSPOLYMER) (ARISTOFLEX HMS by Clariant) Ethanol 3 3 3 3 3 WATER Qs 100 Qs 100 Qs 100 Qs 100 Qs 100 GLYCERINE 10 10 10 10 10 GLYCERYL MONO/DISTEARATE/ 1 1 1 1 1 POLYETHYLENE GLYCOL STEARATE MIXTURE (100 OE) (INCI name: GLYCERYL STEARATE (and) PEG-100 STEARATE) (Arlacel 165 by Croda) POLYETHYLENE GLYCOL STEARATE (40 1 1 1 1 1 OE) (Myrj 52P by Croda) POLYGLYCERYL-5 LAURATE 5 5 5 5 5 (SUNSOFT A-121E-C ® by Taiyo Kagaku) Tackiness when drying 1 1 1 1.5 1.5

[0218] The results show that the formulas 010 to C14 according to the invention, i.e. comprising at least 10% of oils chosen from among C15-C19 branched alkanes, have low tackiness when drying.

Example 6: Preparation of Comparative Compositions

[0219] The following compositions C15 to C17 were prepared with the ingredients mentioned in the following table, using the protocol described above.

TABLE-US-00006 TABLE 6 Formula Formula Formula Comparative Comparative Comparative C15 C16 C17 Ingredient (% w/w) (% w/w) (% w/w) POLYSACCHARIDE 5 5 5 (INCI name: biosacchande gum-2) (Rhamnosoft HP 1.5P by Solabia) AMORPHOUS SILICA MICROSPHERES (5 μm) 2 2 2 Preservative Qs Qs Qs DIPENTAERYTHRITYL 10 20 30 PENTAISONONANOATE ACRYLAMIDO-2-METHYL PROPANE SODIUM 0.4 0.4 0.4 SULFONATE/HYDROXYETHYL ACRYLATE COPOLYMER (INCI: HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER); (SEPINOV EMT 10 by Seppic) AMPS/ETHOXYLATED STEARYL 0.7 0.7 0.7 METHACRYLATE (25 EO) COPOLYMER CROSS-LINKED BY TRIMETHYLOLPROPANE TRIACRYLATE (INCI: AMMONIUM ACRYLOYLDIMETHYLTAURATE/STEARETH- 25 METHACRYLATE CROSSPOLYMER) (ARISTOFLEX HMS by Clariant) Ethanol 3 3 3 WATER Qs 100 Qs 100 Qs 100 GLYCERINE 10 10 10 GLYCERYL MONO/DISTEARATE/ 1 1 1 POLYETHYLENE GLYCOL STEARATE MIXTURE (100 OE) (INCI name: GLYCERYL STEARATE (and) PEG- 100 STEARATE) (Arlacel 165 by Croda) POLYETHYLENE GLYCOL STEARATE (40 OE) 1 1 1 (Myrj 52P by Croda) POLYGLYCERYL-5 LAURATE 5 5 5 (SUNSOFT A-121E-C ® by Taiyo Kagaku) Tackiness when drying 2 2.5 3

[0220] The results show that these comparative formulas, i.e. including various quantities of dipentaerythrityl pentaisononanoate, have strong tackiness when drying.

Example 7: Preparation of Compositions According to the Invention and Comparison with Formula C16

[0221] The following four compositions according to the invention, and the comparative composition C16, were prepared with the ingredients mentioned in the following table, using the protocol described above:

TABLE-US-00007 TABLE 7 Formula Formula Formula Formula according according according according Comparative to to to to formula the the the the Ingredient C16 invention invention invention invention POLYSACCHARIDE 5 5 5 5 5 (INCI name: biosaccharide gum-2) (Rhamnosoft HP 1.5P by Solabia) AMORPHOUS SILICA MICROSPHERES (5 2 2 2 2 2 μm) preservative qs qs Qs Qs qs DIPENTAERYTHRITYL 20 PENTAISONONANOATE Jojoba oil 20 Isononyl isononanoate 20 Isopropyl myristate 20 Mixture of C15-C19 branched alkanes 20 (Emogreen L15) ACRYLAMIDO-2-METHYL PROPANE SODIUM 0.4 0.4 0.4 0.4 0.4 SULFONATE/HYDROXYETHYL ACRYLATE COPOLYMER (SEPINOV EMT 10 by Seppic) AMPS/ETHOXYLATED STEARYL 0.7 0.7 0.7 0.7 0.7 METHACRYLATE (25 EO) COPOLYMER CROSS-LINKED BY TRIMETHYLOLPROPANE TRIACRYLATE (INCI: AMMONIUM ACRYLOYLDIMETHYLTAURATE/ STEARETH-25 METHACRYLATE CROSSPOLYMER)) (ARISTOFLEX HMS by Clariant) Ethanol 3 3 3 3 3 Water Qs 100 Qs 100 Qs 100 Qs 100 Qs 100 GLYCERINE 10 10 10 10 10 GLYCERYL MONO/DISTEARATE/ 1 1 1 1 1 POLYETHYLENE GLYCOL STEARATE MIXTURE (100 OE) (INCI name: GLYCERYL STEARATE (and) PEG-100 Stearate (Arlacel 165 by Croda) POLYETHYLENE GLYCOL STEARATE (40 1 1 1 1 1 OE) (Myrj 52P by Croda) POLYGLYCERYL-5 LAURATE 5 5 5 5 5 (SUNSOFT A-121 E-C ® by Taiyo Kagaku) tackiness when drying 2.5 1.5 1.5 1 1

[0222] The results show that only the formulas according to the invention, each including at least one oil according to the invention, have very low tackiness at the end of application. After 2 minutes 45 s, the tackiness of formula C16 is 2, while the tackiness of each of the formulas according to the invention is equal to 1.

[0223] Therefore the tackiness after drying is lower with formulas according to the invention, relative to the comparative formula C16.

Example 8: Comparison of the Stability of Comparative Formulas (F9 to F13)

[0224] The following comparative formulas F9 to 13 were prepared as described above. Their composition is given in Tables below.

TABLE-US-00008 TABLE 8 F9 F10 F11 (com- (com- (com- Ingredient parative) parative) parative) Biosaccharide gum-2 5 5 5 (Rhamnosoft HP 1.5P by Solabia) (2.5% active material) AMORPHOUS SILICA 3 3 3 MICROSPHERES (5 μm) SPHERICAL CELLULOSE 4.7 4.7 4.7 BALLS (SIZE 4-7 μM) Preservative Qs Qs Qs ISONONYL 18.54 18.54 18.54 ISONONANOATE DIPENTAERYTHRITYL 2.85 2.85 2.85 PENTAISONONANOATE SODIUM ACRYLAMIDO-2- 0.4 0.4 0.4 METHYL PROPANE SULFONATE/ HYDROXYETHYLACRYLATE COPOLYMER IN POWDER FORM (Sepinov EMT 100 by Seppic) AMPS/ETHOXYLATED 0.7 0.7 0.7 STEARYL METHACRYLATE (25 EO) COPOLYMER CROSS-LINKED BY TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) (Aristoflex HMS by Clariant) Ethanol 3 3 3 WATER Qs 100 Qs 100 Qs 100 GLYCERIN 10 10 10 GLYCERYL STEARATE 1 1 1 (and) PEG-100 STEARATE (Arlacel 165 by Croda) PEG-40 STEARATE 1 1 1 (Myrj 52 P by Croda) PG-10 laurate 5 2.5 1 (DECAGLYCERYL MONOLAURATE) (DERMOFEEL G 10 L by Dr Straetmans)

[0225] For these formulas comprising 1%, 2.5% or 5% by weight of PG-10 laurate (F11, F10 and F9 respectively), a reduction in the stability and slip on application are observed.

[0226] Thus, PG-10 laurate does not confer the same effects as the fatty acid and polyglycerol ester comprising 5 to 9 glycerol patterns according to the invention.

TABLE-US-00009 TABLE 9 F12 F13 Ingredient (comparative) (comparative) Biosaccharide gum-2 5 5 (Rhamnosoft HP 1.5P by Solabia) (2.5% active material) AMORPHOUS SILICA MICROSPHERES (5 μm) 3 3 SPHERICAL CELLULOSE BALLS (SIZE 4-7μM) 4.7 4.7 Preservative Qs Qs ISONONYL ISONONANOATE 18.54 18.54 DIPENTAERYTHRITYL PENTAISONONANOATE 2.85 2.85 SODIUM ACRYLAMIDO-2-METHYL PROPANE SULFONATE/ 0.4 0.4 HYDROXYETHYLACRYLATE COPOLYMER IN POWDER FORM (Sepinov EMT 100 by Seppic) AMPS/ETHOXYLATED STEARYL METHACRYLATE (25 EO) 0.7 0.7 COPOLYMER CROSS-LINKED BY TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) (Aristoflex HMS by Clariant) Ethanol 3 3 WATER Qs Qs 100 100 GLYCERIN 10 10 GLYCERYL STEARATE (and) PEG-100 STEARATE 1 1 (Arlacel 165 by Croda) PEG-40 STEARATE 1 1 (Myrj 52 P by Croda) POLYGLYCERYL-4 LAURATE (TEGO CARE PL 4 by Evonik) 5 2.5

[0227] The formulas cannot be produced using PG-4 laurate: the incorporation of 2.5% or 5% by weight of PG-4 laurate, as in comparative formulas F12 and F13, leads to sedimentation and salting out: the formulas cannot be made.

[0228] Thus, PG-4 laurate does not confer the same effects as the ester of fatty acid and of polyglycerol comprising 5 to 9 glycerol patterns according to the invention.

Example 9: Formula According to the Invention

[0229] The following formula according to the invention comprising a hydrophilic active agent is prepared.

TABLE-US-00010 TABLE 10 Formula Ingredient (invention) Biosaccharide gum-2 7.5 (Rhamnosoft HP 1.5P by Solabia) (2.5% active material) AMORPHOUS SILICA MICROSPHERES (5 μm) 3 SPHERICAL CELLULOSE BALLS (SIZE 4-7 μM) 4.7 Preservative Qs ISONONYL ISONONANOATE 18.54 DIPENTAERYTHRITYL PENTAISONONANOATE 2.85 SODIUM ACRYLAMIDO-2-METHYL PROPANE SULFONATE/ 0.4 HYDROXYETHYLACRYLATE COPOLYMER IN POWDER FORM (Sepinov EMT 100 by Seppic) AMMONIUM ACRYLOYLDIMETHYLTAURATE/STEARETH-25 0.7 METHACRYLATE CROSSPOLYMER (Aristoflex HMS by Clariant) Ethanol 3 WATER Qs 100 GLYCERIN 10 GLYCERYL STEARATE (and) PEG-100 STEARATE 1 (Arlacel 165 by Croda) PEG-40 STEARATE 1 (Myrj 52 P by Croda) POLYGLYCERYL-5 LAURATE (SUNSOFT A-121E-C ® by Taiyo Kagaku) 5 Sodium hyaluronate 0.5 Hydroxypropyl tetrahydropyrantriol 8.7 (MEXORYL SCN ® of CHIMEX (=3.045% (35% active material) active material)