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Patent Abstract
Glyphomicins A and B
Patent number: 4842857
Assignee: E. R. Squibb And Sons, Inc. (Princeton, NJ)
Inventors: Edward Meyers (East Brunswick, NJ), William L. Parker (Pennington, NJ)

Cultivation of a strain of the microorganism Micromonospora sp. A.T.C.C. No. 53481, yields the novel antibiotic substance glyphomicin, which is a mixture of glyphomicin A and glyphomicin B.

10'-Desmethoxystreptonigrin
Patent number: 5158960
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Inventors: Edward Meyers (East Brunswick, NJ), Terrence W. Doyle (Killingworth, CT), Veeraswamy Manne (Yardley, PA), Wen-Chih Liu (Princeton Junction, NJ)

10'-Desmethoxystreptonigrin, obtainable by cultivation of a strain of Streptomyces albus, A.T.C.C. No. 55161, and salts, esters and amides thereof. The novel compounds have antitumor and antibiotic activity.

10'desmethoxystreptonigrin production by Streptomyces albus
Patent number: 5320955
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Inventors: Edward Meyers (East Brunswick, NJ), Terrence W. Doyle (Killingworth, CT), Veeraswamy Manne (Yardley, PA), Wen-Chih Liu (Princeton Junction, NJ)

10'-Desmethoxystreptonigrin, obtainable by cultivation of a strain of Streptomyces albus, A.T.C.C. No. 55161, and salts, esters and amides thereof. The novel compounds have antitumor and antibiotic activity.

Antibiotic produced by Bacillus subtilis ATCC 55422 capable of inhibiting bacteria
Patent number: 5364623
Assignee: Bristol Myers Squibb Company (Princeton, NJ)
Inventors: Pramathesh S. Patel (Ringoes, NJ), Friedrich Mayerl (Norwalk, CT), Edward Meyers (East Brunswick, NJ)

The invention is drawn to an antibiotic produced by Bacillus subtilis ATCC 55422 having a nominal molecular weight of 580 and the empirical formula C.sub.35 H.sub.48 O.sub.7, or a salt thereof. The antibiotic is useful in inhibiting the growth of bacteria, including Escherichia, Klebsiella, Proteus, Serratia, Bacillus and Staphylococcus.

Antibiotics xylocandin A and xylocandin B
Patent number: 4601904
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Inventors: Edward Meyers (East Brunswick, NJ), Wen-Chih Liu (Princeton Junction, NJ), Richard B. Sykes (Belle Mead, NJ)

Cultivation of a strain of the microorganism Pseudomonas cepacia which has been deposited in the American Type Culture Collection as A.T.C.C. No. 39277, yields novel antibiotic substances xylocandin A and xylocandin B having activity against yeasts and fungi.