Deflectable catheters, hemostasis valves, and materials for the same are disclosed. The deflectable catheters and hemostasis valves can be made at least partially, if not entirely, from a fluoroelastomer and ePTFE combination. A deflectable region of the catheters can be articulated to form simple and/or complex curves.

Methods and apparatuses for extracting, modifying and returning cells to/from a patient to treat the patient. These apparatuses and methods may use nanostraws to deliver biologically relevant molecules such as DNA, RNA, proteins etc., into the cells rapidly and efficiently. The methods and apparatuses described herein are repeatedly capable of delivering biologically relevant cargo into cells with high cell viability, dosage control, unaffected proliferation or cellular development, and with high efficiency, including in a continuous or semi-continuous manner.

The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective amount of a composition comprising: (A) at least one taurinamide derivative, (B) at least one compound selected from the group consisting of biologically acceptable acids and biologically acceptable salts thereof; and (C) heparin at a low concentration.

The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective amount of a composition comprising: (A) at least one taurinamide derivative, (B) at least one compound selected from the group consisting of biologically acceptable acids and biologically acceptable salts thereof; and (C) heparin at a low concentration.

A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.

Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.

A material non-adhesive to a biological substance containing: a polymer compound (A) which includes a repeating unit derived from a sulfobetaine monomer represented by Formula (I) or (II).

##STR00001##

In the formulae, R.sup.1 represents a methyl group, an ethyl group, an n-propyl group, or an isopropyl group, a plurality of R.sup.1's may be the same as or different from each other.

R.sup.2 represents a hydrogen atom or a methyl group.

n represents an integer of 2 to 4.

L represents a linear or branched alkylene group having 3 or 4 carbon atoms.

A material non-adhesive to a biological substance containing: a polymer compound (A) which includes a repeating unit derived from a sulfobetaine monomer represented by Formula (I) or (II).

##STR00001##

In the formulae, R.sup.1 represents a methyl group, an ethyl group, an n-propyl group, or an isopropyl group, a plurality of R.sup.1's may be the same as or different from each other.

R.sup.2 represents a hydrogen atom or a methyl group.

n represents an integer of 2 to 4.

L represents a linear or branched alkylene group having 3 or 4 carbon atoms.

An occlusion-resistant catheter, occlusion-resistant catheter tip, and methods of use are disclosed. In one embodiment, the occlusion-resistant catheter includes a hollow cannula defining a fluid passageway therethrough, the hollow cannula having a body portion with a first end and a second end, and an occlusion-resistant tip positioned at the first end of the body portion. The occlusion-resistant tip has at least one port that provides access to an interior lumen, and the interior lumen is in fluid communication with the fluid passageway of the body portion.