Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

Provided is a syringe gasket including a first member, and a second member connected to the first member and coupled to a plunger rod of a syringe. The first member includes a top face contacting with the liquid, and a first side circumferential face that faces an inner circumferential face of a barrel of the syringe. The first side circumferential face has, at an end portion thereof close to the second member, a ring-like trimmed face. An inert film is laminated on the top face and the portion of the first side circumferential face other than the ring-like trimmed face. The second member includes a second side circumferential face that faces the inner circumferential face of the barrel, and a ring-like protruding portion that projects outward in the radial direction from the second side circumferential face. The ring-like protruding portion at least partially covers the ring-like trimmed face.

A needle guard grip device may include a body extending from a first end to a second end along a central longitudinal axis of the body. The body may include a plurality of ribs extending perpendicularly to the central longitudinal axis. The plurality of ribs may include a first set of longitudinally spaced ribs disposed on a first side of the central longitudinal axis, and a second set of longitudinally spaced ribs disposed on a second side of the central longitudinal axis that is opposite of the first side. Moving along the central longitudinal axis, ribs of the first set of longitudinally spaced ribs may alternate with ribs of the second set of longitudinally spaced ribs.

A catheter includes a shaft and a hub that are firmly fixed to each other. The shaft is a tubular body in which a lumen extends throughout the shaft from a distal end to a proximal end. The shaft includes a shaft proximal surface at which the lumen opens and a shaft outer surface that is an outer peripheral surface of the tubular body. The hub is attached to the proximal end of the shaft. The hub includes a tubular accommodation unit configured to accommodate the shaft. The accommodation unit includes a hub melted surface directly welded to the shaft outer surface, and at least one of the accommodation unit and the hub is formed with a plurality of cavities at a position close to the hub melted surface.

A method of manufacturing a medical device including a case having a first and a second case portion mated together. The case having a space inside and an elastic membrane attached to the case. A first housing space covered by the first case portion and a second housing space covered by the second case portion. Fixing parts at peripheries of the first and the second case portions and at which the first and the second case portions are mated. Holding surfaces at the peripheries of the first and the second case portions. A sealing part at the periphery of the first or the second ease portions with respect to the fixing parts and that seals an entirety of the peripheral edge of the elastic membrane. Forming an air gap between the sealing part and the fixing parts by depressurization or heating the fixing parts that connect the case portions.

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

A wearable device for providing haptic stimulations is provided. The wearable device includes: (i) a wearable structure to be worn on a portion of a user's body and (ii) an inflatable bladder, coupled to the wearable structure, that includes two or more pockets positioned at a target location on the wearable structure. Furthermore, the two or more pockets are configured to, when inflated, impart directional force(s) onto the user at the target location that impede movement of the portion of the user's body. Additionally, the directional force(s) are caused by the two or more pockets interfering with each other, when inflated. In some embodiments, (a) the portion of the user's body is a hand of the user, (b) the target location is a finger joint on the user's hand, and (c) the directional force(s) imparted onto the user at the target location impede flexion of the user's finger.

A multi chamber syringe unit includes a longitudinal body with side wall, distal end side, proximal end side opposite to distal end side, an interior limited by side wall between distal end side and proximal end side and distal opening arranged in distal end side for providing a liquid out of the body. The syringe further includes a separating element arranged in the interior of the body such that distal chamber and proximal chamber are formed in the interior of the body, wherein the separating element seals the distal chamber from the proximal chamber. The syringe has a bypass arrangement provided in the side wall of distal chamber of the body. A first pharmaceutical liquid is arranged in distal chamber of the body and second pharmaceutical liquid in proximal chamber of the body. The multi chamber syringe unit allows for adequately administering plural pharmaceutical liquids by injection.

A cartridge for an aerosol-generating system is provided, including a liquid storage portion including a housing containing a liquid aerosol-forming substrate, the housing having an open end; and a heater assembly including: an electrical heating element configured to heat the substrate to form an aerosol, the heating element including a planar filament arrangement having one or more electrically conductive filaments, an electrically insulating substrate having a planar attachment face, the filament arrangement disposed on the planar attachment face, and clamping elements mechanically fixing the filament arrangement to the electrically insulating substrate and applying a pulling force onto the filament arrangement, at least a portion of the heater assembly being fluid-permeable, and the heater assembly being arranged over the open end of the housing.

A patient interface includes a plenum chamber pressurisable to a therapeutic pressure, and a seal-forming structure constructed and arranged to seal with a region of a patient's face surrounding an entrance to a patients airways. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in the plenum chamber throughout a patients respiratory cycle in use. The patient interface also includes a positioning and stabilizing structure configured to hold the seal-forming structure in a therapeutically effective position on a patients head. The positioning and stabilizing structure includes a rear strap arranged to contact an occiput of the patients head. The rear strap is constructed from a first material is arranged to contact a temporal region of the patients head, and a second material arranged to contact the occiput of the patients head. The second material is silicone.