A histotripsy device may include a headset configured to be mounted to an about a cranium of a human or animal, at least one transducer mounted to the headset and positioned such that, with the headset mounted to and about the cranium, the at least one transducer is positioned over and in contact with at least one temporal or suboccipital region of the cranium, wherein the at least one transducer is configured to emit focused radiation in at an ultrasonic frequency or frequency range, at least one processor, and at least one memory having instructions stored therein executable by the at least one processor to cause the at least one processor to activate the at least one transducer to produce at least one pulse of ultrasonic radiation having a pulse duration of 1 milliseconds or longer.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

An ablation system comprises: an ablation catheter and a console. The ablation catheter comprises: a shaft including a proximal end, a distal portion and a distal end; an ablation element configured to deliver energy to tissue; and a force maintenance assembly comprising a force maintenance element and configured to control and/or assess contact force between the ablation element and cardiac tissue. The console is configured to operably attach to the ablation catheter and comprises: an energy delivery assembly configured to provide energy to the ablation element. Methods of ablating tissue are also provided.

A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

One or more devices, systems, and methods are described which together provide sonoluminescence biophysical oscillation technique(s) (SBOT(s)) that improve debilitated states of health for individuals comprising; biophysical oscillations that initiate, sustain, and/or control one or more sound emitting devices including speakers capable of providing harmonic and subharmonic sound and including music and/or individual musical notes that provide sound tracsons and one or more light emission devices including projectors that provide light wave emission traclums which are capable of imparting color changes, wherein tracsons and traclums provide auditory and visual stimuli that result in energy changes that create acoustic and tracson/traclum excitations. The tracson/traclum excitations are applied in an external manner to one or more bodies of humans and in some cases could be applied to animals.

One or more devices, systems, and methods are described which together provide sonoluminescence biophysical oscillation technique(s) (SBOT(s)) that improve debilitated states of health for individuals comprising; biophysical oscillations that initiate, sustain, and/or control one or more sound emitting devices including speakers capable of providing harmonic and subharmonic sound and including music and/or individual musical notes that provide sound tracsons and one or more light emission devices including projectors that provide light wave emission traclums which are capable of imparting color changes, wherein tracsons and traclums provide auditory and visual stimuli that result in energy changes that create acoustic and tracson/traclum excitations. The tracson/traclum excitations are applied in an external manner to one or more bodies of humans and in some cases could be applied to animals.