The present invention relates to a device (60) for manufacturing pharmaceutical compositions, comprising: a support (62); a mixing container (16); a plurality of reservoirs (18, 20) containing starting materials for the composition of a medicament; at least one dispensing device (64, 66) that is designed to dispense an amount of a starting material into the mixing container, wherein the dispensing device is assembled, or is designed to be assembled, with a reservoir; a stirring device (68) that is able to stir the mixing container and/or the contents of the mixing container; and an electronic module (74) for controlling the at least one dispensing device.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.

A mixing system includes a container having an encircling sidewall bounding a chamber and extending between an upper end and an opposing lower end; a support plate disposed within the chamber and secured to the encircling sidewall; an inner wall secured to the support plate and projecting within the chamber toward the upper end, an open space being formed between the inner wall and the encircling sidewall; and a first aperture extending through the encircling sidewall so as to communicate with the open space. A mixing assembly is positioned within the container and is supported on the support plate, the mixing assembly including a pliable enclosure and a mixing device.

A mixing system includes a container having an encircling sidewall bounding a chamber and extending between an upper end and an opposing lower end; a support plate disposed within the chamber and secured to the encircling sidewall; an inner wall secured to the support plate and projecting within the chamber toward the upper end, an open space being formed between the inner wall and the encircling sidewall; and a first aperture extending through the encircling sidewall so as to communicate with the open space. A mixing assembly is positioned within the container and is supported on the support plate, the mixing assembly including a pliable enclosure and a mixing device.

A mixing system for use in a process bottle for mixing its contents, the mixing system including a low volume magnetically-driven mixer mounted at the bottom of the bottle. The mixer may have vanes and lower grooves, or no vanes and grooves on both upper and lower faces. The mixer has a microsized three-dimensional solid inanimate body to enable insertion through relatively small mouth openings at the top of conventional reactor bottles. Methods of assembly are also disclosed which involve passing the microsized mixer through an open mouth of a process bottle and coupling the mixer with a bearing assembly at the floor of the bottle. The bearing assembly includes fixtures sealed around a hole in the floor of the bottle.

The present invention relates to a magnetic mixer to which a disposable resin liquid pouch is applied instead of a metal tank, for accommodating and mixing liquids therein, to minimize cross-contamination of liquids to be mixed due to an unwashed residue, increase a magnetic coupling force between rotors for driving an impeller inside the liquid pouch and an impeller outside the liquid pouch by a magnetic coupling method, and prevent separation of the impeller in liquids to be mixed, and a magnetic mixing system.

To introduce a reagent with a small amount of residual liquid and enable a fluidic manipulation by deformation of an elastic film, a sealed type of sample processing device is configured with a reagent storage including a joint portion which joins an upper film and a lower film at a periphery of a storage space which stores a reagent between both films, an analysis chip including a lower surface fluid channel through which a liquid flows on a lower surface side and an upper surface fluid channel through which the liquid flows on an upper surface side, and an elastic film which seals the lower surface side of the analysis chip. A portion of the lower film is joined to the upper surface side of the analysis chip, a removed portion, in which the lower film is partially removed, is in an upper part of the upper surface fluid channel.

A fluid mixing system includes a flexible bag having a first end, an opposing second end, and an interior surface bounding a compartment; a retainer coupled to the second end of the flexible bag, the retainer having a retention cavity formed thereon that communicates with the compartment of the flexible bag; and an elongated member having a first end rotatably coupled to the first end of the flexible bag and an opposing second end freely disposed within the retention cavity of the retainer so that the second end of the elongated member can rotate within the retention cavity relative to the retainer.

A static homogenizing apparatus for blending a fluid additive with a polymer melt includes: (a) a homogenizing conduit; and (b) a plurality of homogenizing elements in the conduit for flow of the melted resin and fluid additive through the homogenizing elements in series. The plurality of homogenizing elements includes a plurality of mixing elements and at least one amplifier element. Each mixing element has a quantity of mixing channels passing therethrough, and each amplifier element has a quantity of amplifier channels passing therethrough. The quantity of amplifier channels is greater than the quantity of mixing channels.