A blood separation system is provided that includes a blood separation device that includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case and a fluid flow circuit having both a separation chamber configured to be mounted in the centrifugal separator of the blood separation device and a spinning membrane separator configured to be received in the spinning membrane separator drive unit. In an exemplary procedure, the system is used to collect concentrated platelets and/or concentrated platelets and plasma, and to further permit harvesting of the mononuclear cells from the centrifugal separator at the conclusion of platelet collection, and transfer of the mononuclear cells to the spinning membrane separator.

A centrifuge is configured to provide integrated separation of blood components such that the separated products remain spinning within the centrifuge during the separation process. The centrifuge includes a disposable configured to separate the blood components such that the separated products remain within the disposable while the centrifuge is spinning; an integrated sensor system capable of determining a composition of the separated products within the disposable while the centrifuge is spinning; a chamber having a non-circular section that is configured to be deliberately un-balanced when the centrifuge chamber is empty; and the disposable includes valves that rotate with the centrifuge chamber.

A centrifuge is configured to provide integrated separation of blood components such that the separated products remain spinning within the centrifuge during the separation process. The centrifuge includes a disposable configured to separate the blood components such that the separated products remain within the disposable while the centrifuge is spinning; an integrated sensor system capable of determining a composition of the separated products within the disposable while the centrifuge is spinning; a chamber having a non-circular section that is configured to be deliberately un-balanced when the centrifuge chamber is empty; and the disposable includes valves that rotate with the centrifuge chamber.

A method for determining if air is trapped within a centrifugal separator, the separator including a stationary frame, a rotatable assembly, a drive unit for rotating the rotatable assembly relative the frame around an axis of rotation, a feed inlet for supply of a liquid mixture to be separated, a first liquid outlet for discharge of a separated liquid phase and a second liquid outlet for discharge of a heavy phase having a density that is higher than said liquid phase. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around a vertical axis of rotation. The method includes closing one of the first and second liquid outlets and restricting the flow from the other outlet; supplying feed to the feed inlet and measuring the flow to the feed inlet and the flow from the restricted outlet; comparing the flow as a function of time between feed inlet and the restricted outlet; and determining that air is trapped within the centrifugal separator if the measured flow as a function of time flow deviates between feed inlet and the restricted outlet.

A method for determining if air is trapped within a centrifugal separator, the separator including a stationary frame, a rotatable assembly, a drive unit for rotating the rotatable assembly relative the frame around an axis of rotation, a feed inlet for supply of a liquid mixture to be separated, a first liquid outlet for discharge of a separated liquid phase and a second liquid outlet for discharge of a heavy phase having a density that is higher than said liquid phase. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around a vertical axis of rotation. The method includes closing one of the first and second liquid outlets and restricting the flow from the other outlet; supplying feed to the feed inlet and measuring the flow to the feed inlet and the flow from the restricted outlet; comparing the flow as a function of time between feed inlet and the restricted outlet; and determining that air is trapped within the centrifugal separator if the measured flow as a function of time flow deviates between feed inlet and the restricted outlet.

The present disclosure relates to methods and devices for the separation of blood components including separation by rapid sedimentation, including in an automated fashion.

The present disclosure relates to methods and devices for the separation of blood components including separation by rapid sedimentation, including in an automated fashion.

A fluid separation device includes a centrifuge in which a fluid is separated into at least two components, with an interface therebetween. At least a portion of one of the separated fluid components is removed from the centrifuge and flows through a vessel. Light is reflected off of the separated fluid component in the vessel and received and analyzed to determine its main wavelength. If the main wavelength is higher than a maximum value, a target location of the interface is changed. If the main wavelength is less than the maximum value, then the location of the interface is compared to the target location. When the interface is sufficiently close to the target location, the optical density of the separated fluid component in the vessel is compared to a minimum value. If the optical density is less than the minimum value, the target location of the interface is changed.

A portable motorized centrifugal system is optimized for low cost manufacture and operation. Separation of inhomogeneous fluid biological samples, such as liquid plasma from whole blood, is a common step in medical diagnostic tests. This system may enable remote separation where access to plug-in power sources are limited. The system may facilitate at-home testing. Due to biohazard concerns, the entire centrifugal apparatus portable and disposable, or the system includes one or more disposable elements within the interior of the centrifuge. Alternatively, the system may contain a module of higher value components that are re-usable after disinfection. Devices and methods for implementing centrifugal separation may include disk-shaped fluidic cartridges and tubes with reduced drag cross-section.

A portable motorized centrifugal system is optimized for low cost manufacture and operation. Separation of inhomogeneous fluid biological samples, such as liquid plasma from whole blood, is a common step in medical diagnostic tests. This system may enable remote separation where access to plug-in power sources are limited. The system may facilitate at-home testing. Due to biohazard concerns, the entire centrifugal apparatus portable and disposable, or the system includes one or more disposable elements within the interior of the centrifuge. Alternatively, the system may contain a module of higher value components that are re-usable after disinfection. Devices and methods for implementing centrifugal separation may include disk-shaped fluidic cartridges and tubes with reduced drag cross-section.