A method for washing platelets includes introducing anticoagulant into a platelet product container, drawing re-anticoagulated platelet product from the platelet product container, and introducing it into a centrifuge bowl. The centrifuge bowl separates the platelets from the supernatant in which they are suspended. The method then washes the platelets by introducing wash solution into the centrifuge bowl. As the wash solution is introduced into the bowl, it displaces the supernatant from the bowl and into a waste container. The method then introduces platelet additive solution into the centrifuge bowl, which displaces the wash solution from the centrifuge bowl and into the waste container and further wash the platelets. The method then repeatedly accelerates and decelerates the centrifuge bowl to resuspend the platelets in the platelet additive solution.

A method for washing platelets includes introducing anticoagulant into a platelet product container, drawing re-anticoagulated platelet product from the platelet product container, and introducing it into a centrifuge bowl. The centrifuge bowl separates the platelets from the supernatant in which they are suspended. The method then washes the platelets by introducing wash solution into the centrifuge bowl. As the wash solution is introduced into the bowl, it displaces the supernatant from the bowl and into a waste container. The method then introduces platelet additive solution into the centrifuge bowl, which displaces the wash solution from the centrifuge bowl and into the waste container and further wash the platelets. The method then repeatedly accelerates and decelerates the centrifuge bowl to resuspend the platelets in the platelet additive solution.

A fluid processing device includes a controller, a centrifuge, and a pump system. The controller controls the pump system to convey a fluid into a centrifuge chamber received by the centrifuge at first and second rates, with the controller also controlling the centrifuge to rotate the chamber at a first rotation rate when the fluid is being conveyed into the chamber at the first rate and controlling the centrifuge to rotate the chamber at a second rotation rate when the fluid is being conveyed into the chamber at the second rate. The first and second rotation rates are different, with each being based at least in part on a concentration of a fluid component within the fluid, the rate at which the pump system is conveying the fluid into the centrifuge chamber, and a target concentration of the fluid component in one of the first and second constituents.

A fluid processing device includes a controller, a centrifuge, and a pump system. The controller controls the pump system to convey a fluid into a centrifuge chamber received by the centrifuge at first and second rates, with the controller also controlling the centrifuge to rotate the chamber at a first rotation rate when the fluid is being conveyed into the chamber at the first rate and controlling the centrifuge to rotate the chamber at a second rotation rate when the fluid is being conveyed into the chamber at the second rate. The first and second rotation rates are different, with each being based at least in part on a concentration of a fluid component within the fluid, the rate at which the pump system is conveying the fluid into the centrifuge chamber, and a target concentration of the fluid component in one of the first and second constituents.

A centrifuge includes a chamber configured to contain a set of one or more samples, an image sensor configured to generate image data, and processing circuitry. The processing circuitry is configured to: initiate centrifugation of the set of samples about a central axis; obtain a set of image data generated by the image sensor during centrifugation of the set of samples; and for each respective sample of the set of samples, apply a machine learning model configured to generate, based on image data representative of the respective sample in the set of image data, a viability score for the respective sample; determine whether the viability score for the respective sample satisfies a viability condition; and output whether the viability score for the respective sample satisfies the viability condition.

A centrifuge includes a chamber configured to contain a set of one or more samples, an image sensor configured to generate image data, and processing circuitry. The processing circuitry is configured to: initiate centrifugation of the set of samples about a central axis; obtain a set of image data generated by the image sensor during centrifugation of the set of samples; and for each respective sample of the set of samples, apply a machine learning model configured to generate, based on image data representative of the respective sample in the set of image data, a viability score for the respective sample; determine whether the viability score for the respective sample satisfies a viability condition; and output whether the viability score for the respective sample satisfies the viability condition.

The disclosed apparatus, systems and methods relate to sample preparation and shipping technologies in a single shippable container. The shipping container contains a single use centrifuge. The centrifuge can be temperature controlled and meets all standards and regulations for the shipping and transport of biological specimens.

The disclosed apparatus, systems and methods relate to sample preparation and shipping technologies in a single shippable container. The shipping container contains a single use centrifuge. The centrifuge can be temperature controlled and meets all standards and regulations for the shipping and transport of biological specimens.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.