An estimation method performed by a computer, the method comprising: distinguishing ground-off and landing timings of respective four limbs of an animal based on measurement data acquired by using a motion sensor attached to the animal which has four limbs, and identifying a limb which interlocks with a disorder of a motion waveform upon a motion of the animal, based on the distinguished ground-off and landing timings of each of the four limbs of the animal.

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

The present invention relates to an insect spawning container in which at least one spawn structure is provided in which the mother insects will spawn their eggs. The spawn structure has a scalable face such that the mother beetles can crawl from the bottom onto and up along the scalable face of the spawn structure, the spawn structure comprising a multitude of crevices accessible from the scalable face, the crevices having dimensions tuned to the egg-laying tube of the mother beetles.

The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

A body surface temperature measurement device capable of appropriately performing measurement of a body surface temperature of an animal is realized. A body surface temperature measurement device includes a temperature sensing unit including an infrared ray detection sensor and a cover that covers the infrared ray detection sensor, in which the cover closely contacts a body surface of the animal and at least a part of a contact surface of the cover, which contacts the body surface of the animal, is formed into a curved surface that bulges toward a body surface side of the animal.

The present invention is related to a method of and a system for growing, maintaining, and/or harvesting living organisms such as plants and/or animals by controlling their physiology and lifetime according to sidereal time, preferably yet not necessarily in phase with sidereal time.

The present invention is related to a method of and a system for growing, maintaining, and/or harvesting living organisms such as plants and/or animals by controlling their physiology and lifetime according to sidereal time, preferably yet not necessarily in phase with sidereal time.

A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron centre selected from amino acids or -hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine. Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed. Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.