When utilizing a flying vehicle to monitor an animal that is grazing, the stress of the animal targeted for monitoring is mitigated. An acquisition unit acquires position information indicating the position of an animal that is grazing. A determination unit determines the reactivity of the animal to the approach of a flying vehicle. A setting unit sets a distance that depends on the determined reactivity. An instruction unit instructs the flying vehicle to start flying toward a monitoring position corresponding to the position indicated by the acquired position information and the set distance, and to perform processing for monitoring the animal on the basis of the monitoring position.

Described herein is a method for producing a chimeric non-human animal expressing a human NKX2-5, HANDII, TBX5 gene or a combination thereof gene comprising: a) generating a NKX2-5, HANDII, TBX5 or combination thereof null non-human animal cell, wherein both copies of the non-human NKX2-5, HANDII, TBX5 gene or combination thereof carry a mutation that prevents production of functional NKX2-5, HANDII, TBX5 protein or combination thereof in said non-human animal; b) creating a NKX2-5, HANDII, TBX5 or combination thereof null non-human blastocyst by somatic cell nuclear transfer comprising fusing a nucleus from said NKX2-5, HANDII, TBX5 or combination thereof null non-human animal cell of a) into an enucleated non-human oocyte and activating said oocyte to divide so as to form an NKX2-5, HANDII, TBX5 or combination thereof null non-human blastocyst; c) introducing human stem cells into the NKX2-5, HANDII, TBX5 or combination null non-human blastocyst of b); and d) implanting said blastocyst from c) into a pseudopregnant surrogate non-human animal to generate a chimeric non-human animal expressing human NKX2-5, HANDII, TBX5 or combination thereof.

Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature. One embodiment includes compositions and methods for making livestock with a polled allele, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions.

The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.

The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.

Described herein is a method for producing a chimeric non-human animal expressing a human a MYF5, MYOD, MRF4 gene or a combination thereof gene comprising: a) generating an MYF5, MYOD, MRF4 or combination thereof null non-human animal cell, wherein both copies of the non-human MYF5, MYOD, MRF4 gene or combination thereof carry a mutation that prevents production of functional MYF5, MYOD, MRF4 protein or combination thereof in said non-human animal; b) creating a MYF5, MYOD, MRF4 or combination thereof null non-human blastocyst by somatic cell nuclear transfer comprising fusing a nucleus from said MYF5, MYOD, MRF4 or combination thereof null non-human animal cell of a) into an enucleated non-human oocyte and activating said oocyte to divide so as to form an MYF5, MYOD, MRF4 or combination thereof null non-human blastocyst; c) introducing human stem cells into the MYF5, MYOD, MRF4 or combination null non-human blastocyst of b); and d) implanting said blastocyst from c) into a pseudopregnant surrogate non-human animal to generate a chimeric non-human animal expressing human MYF5, MYOD, MRF4 or combination thereof.

There is provided a computer system for evaluating the quality of a fertile ovum. The computer system includes computer processing circuitry configured to receive a plurality of images of a fertile ovum captured in time-series by an imaging apparatus, provide as input to at least one learned model, the plurality of images of the fertile ovum or information based on the plurality of images of the fertile ovum, wherein the at least one learned model has been trained to output, based at least in part, on the plurality of images, fertile ovum analysis information describing characteristics of the fertile ovum used to evaluate a quality of fertile ovum, and provide evaluation support information based, at least in part, on the fertile ovum analysis information, wherein the evaluation support information enables a quality evaluator to interact with the web dashboard to modify at least some of the evaluation support information.

There is provided a computer system for evaluating the quality of a fertile ovum. The computer system includes computer processing circuitry configured to receive a plurality of images of a fertile ovum captured in time-series by an imaging apparatus, provide as input to at least one learned model, the plurality of images of the fertile ovum or information based on the plurality of images of the fertile ovum, wherein the at least one learned model has been trained to output, based at least in part, on the plurality of images, fertile ovum analysis information describing characteristics of the fertile ovum used to evaluate a quality of fertile ovum, and provide evaluation support information based, at least in part, on the fertile ovum analysis information, wherein the evaluation support information enables a quality evaluator to interact with the web dashboard to modify at least some of the evaluation support information.

An insect sortation system can track movement of insects along a predefined pathway. The insect sortation system includes a puff-back system for moving insects toward an inlet of the pathway and a puff-forward system for moving insects toward an outlet of the pathway. An overhead imaging system captures images of the insects at one or more locations along the pathway. Once imaged, the insect may be classified into a category (e.g., sex category, species category, size category, etc.) using a variety of different classification approaches including, for example, an industrial vision classifier and/or a machine learning classifier. Once classified, the insects can be directed to various chambers for subsequent processing.

An insect sortation system can track movement of insects along a predefined pathway. The insect sortation system includes a puff-back system for moving insects toward an inlet of the pathway and a puff-forward system for moving insects toward an outlet of the pathway. An overhead imaging system captures images of the insects at one or more locations along the pathway. Once imaged, the insect may be classified into a category (e.g., sex category, species category, size category, etc.) using a variety of different classification approaches including, for example, an industrial vision classifier and/or a machine learning classifier. Once classified, the insects can be directed to various chambers for subsequent processing.