The present invention relates to a method of manufacturing a hyaluronate film and a hyaluronate film manufactured thereby, and more particularly to a method of manufacturing a hyaluronate film through a solvent-casting process or using an automatic film applicator that facilitates mass production and to a hyaluronate film manufactured thereby, which is useful as a mask pack for cosmetics, a patch for medicaments and medical devices, a film-type adhesion inhibitor, etc. Unlike conventional liquid products, the hyaluronate film according to the present invention has a dry surface and thus entails no concern about microbial contamination, is easy to produce/manage/distribute/use, and has superior mechanical properties, whereby it can be utilized for various applications such as packs, patches, artificial skin and the like for cosmetics, medicaments, and medical devices.

Disclosed herein is a microneedle array comprising a substrate and a plurality of microneedles extending therefrom, wherein the microneedles comprise a biodegradable polymer and an effective amount of an analgesic or an anti-inflammatory therapeutic agent. Methods of using and making the microneedle array are also disclosed.

A method for preparing keratin-based composites includes mixing polysaccharide nanoparticles and a keratin solution to form a nanoparticle-keratin solution; and solvent casting the nanoparticle-keratin solution to form the keratin-based composites.

A protein/polysaccharide/essential oil nano-edible film. The essential oil nano-edible film includes the following raw materials in parts by weight: 1-8 parts of a quinoa protein—Atrina pectinata polysaccharide nanocomposite, 2-11 parts of an Atrina pectinata polysaccharide-essential oil nanocomposite, 1-12 parts of a quinoa protein, 2-16 parts of Atrina pectinata polysaccharide, and 5-53 parts of water. The present invention helps to solve the problem, in a conventional protein film, of the loss of flavor and even toxic side effects caused by the adding of a plasticizer and a crosslinking agent to improve the mechanical strength, the use of a lipid substance that has the capability to easily form a dense molecular network structure to improve the water and gas barrier properties, and the migration of an additive, the plasticizer, or a polymer degradation by-product thereof generated in reaction, and a solvent remaining in the polymerization reaction from the film to food.

An artificial flower, plant, or other botanical is produced from an aqueous agar-based solidifying mixture. The artificial botanical may be colored as desired by adding one or more colorants. The artificial botanical may also be scented by adding a perfume, odorant, or other scent. Because the artificial botanical is produced using the aqueous agar-based solidifying mixture, no animal-based gelatin products are. The artificial botanical may thus also be edible and satisfies vegan diets. The artificial botanical may thus also be flavored by adding a flavoring, such as fruit, concentrate, or sweetener. The artificial botanical may be all-natural and edible by adding mica powder as the colorant and by adding glycerin as the flavoring.

Systems, apparatus and methods for producing objects with cryogenic 3D printing with controllable micro and macrostructure with potential applications in tissue engineering, drug delivery, and the food industry. The technology can produce complex structures with controlled morphology when the printed 3D object is immersed in a liquid coolant, whose upper surface is maintained at the same level as the highest deposited layer of the object. This ensures that the computer-controlled process of freezing is controlled precisely and already printed frozen layers remain at a constant temperature. The technology controls the temperature, flow rate and volume of the printed fluid emitted by the dispenser that has X-Y positional translation and conditions at the interface between the dispenser and coolant surface. The technology can also control the temperature of the pool of liquid coolant and the vertical position of the printing surface and pool of coolant liquid.

The invention relates to a method for producing three-dimensional, preferably porous, hydrogel structures by means of layer build-up technique, wherein the method comprises the following steps. Providing (S1) of a liquid hydrogel solution, preferably a liquid alginate solution, and a, preferably transportable, sample carrier. Layerwise applying (S2) the liquid hydrogel solution onto the sample carrier in a temperature environment, the temperature of which is below the freezing point of the hydrogel solution, to produce a frozen 3D layered hydrogel structure. In order to increase advantageously the porosity of the 3D layered hydrogel structure, i.e. the proportion of small voids, cavities and/or depressions in the 3D layered hydrogel structure, the method according to the invention further comprises the step of drying (S3) of the frozen 3D layered hydrogel structure, e.g. by means of freeze-drying, to produce a porous 3D hydrogel structure. The invention relates further also to a device for the layerwise building-up of three-dimensional hydrogel structures.

A glove is provided that includes an outer layer and an inner layer. The outer layer includes a polyvinyl alcohol (PVA) composite including PVA chemically modified with nano cellulose and pre cross linked nitrile latex. The inner layer includes nitrile latex.

A surgical simulator for electrosurgical training and simulation is provided. The surgical simulator includes one or more simulated tissue structures made substantially of a hydrogel comprising a dual interpenetrating network of ionically cross-linked alginate and covalently cross-linked acrylamide. Combinations of different simulated tissue structures define procedural-based models for the practice of various electrosurgical procedures including laparoscopic total mesorectal excision, transanal total mesorectal excision, cholecystectomy and transanal minimally invasive surgery. Methods of making the simulated tissue structures are also provided.

Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50). In the step of peeling off, pressing force is applied to a part of the step portion (52) in a second direction (B) opposite to a first direction (A) in which the transdermal absorption sheet (120) is released from the mold (50), and the transdermal absorption sheet (120) is aspirated with a vacuum suction pad (160) from a side opposite to the mold (50) so that the transdermal absorption sheet (120) is peeled off from the mold (50) in the first direction (A).