Materials and methods for cell-mimetics having mechanical properties of biological neural axons are provided. A cell-mimetic device includes an array of fibers comprised of hexanediol diacrylate (HDDA) or an HDDA derivative, and at least one derivative of polyethylene glycol (PEG) selected from the group consisting of: PEG-acrylate, PEG-diacrylate, and any multi-arm PEG-acrylate.

The present invention refers to a method for additive manufacturing a silicone elastomer article using a 3D printer selected from an extrusion 3D printer and a 3D jetting printer, in which a soluble support material composition V is used, which comprises: (A) at least one polyorganosiloxane, (B) at least one polyether or polymer containing polyether moiety, (C) silica; to a silicone elastomer article obtainable by the method of present invention; and to the use of a support material composition V for 3D printing a support, preferably by extrusion.

A flexible sheet for neurostimulation is described having a flexible non-conductive substrate matrix in which electrodes are embedded along a lower surface. Electrically conductive wires extend from the electrodes through the flexible substrate to another exterior surface of the substrate. Methods of making the flexible sheet and making a device using the flexible sheet are also disclosed.

A polymer composition that includes a blended resin having a viscosity below 10 pascal-seconds before exposure to actinic radiation is provided. The blended resin includes a first base component that is photocurable, and the first base component includes (i) a first siloxane polymer including a plurality of thiol groups and (ii) a second siloxane polymer including a plurality of functional groups with unsaturated carbon-carbon bond. The blended resin also includes a photoinitiator, a second base component that is condensation curable, and a catalyst. The first base component is configured to polymerize into a primary polymer network and the second base component is configured to polymerize into a secondary polymer network. Furthermore, the primary and secondary polymer networks together form an interpenetrating polymer network.

The present invention relates to a thermoplastic silicone-polyurethane elastomer and a method for preparing the same. The elastomer is prepared from raw materials comprising: 25-80 parts of a macromolecular polyol, 0-60 parts of a silicone oil or a liquid silicone rubber, 10-50 parts of a diisocyanate, 3-20 parts of a small molecular diol as a chain extender, and 0.1-3 parts of an auxiliary agent. The macromolecular polyol is selected from a silicon-free polyol having a molecular weight of between 1,000 and 4,000 g/mol and a polyol modified by silicone through copolymerization or grafting. The small molecular diol is a small molecular diol comprising 10 or less carbon atoms. The thermoplastic silicone-polyurethane elastomer of the present invention has the following excellent performance parameters: a hardness of Shore A40-D80; a tensile strength ≥5 MPa; smooth hand feeling; resistance to dirt such as dust; resistance to liquid permeation; no irritation to skin; good encapsulation effect on PC, ABS, TPU and the like; and a 180° peel strength >25 N/25 mm.

The present disclosure relates to compositions and methods for three-dimensional printing.

The present invention discloses a steerable guidewire and a method for manufacturing the same, and a steerable catheter and a method for manufacturing the same. According to an aspect of the present invention, a steerable guidewire, which is inserted into a catheter and guides the catheter to a desired blood vessel, may include: a steerable tip part that can be bent in at least two stages due to a stimulus from the outside and that is steered in a predetermined direction; and a non-steerable tip part that is not steerable. The steerable tip part may include: a first steerable tip part having a first length and bent in a first angle with respect to the non-steerable tip part; and a second steerable tip part having one end connected to the first steerable tip part, having a second length, and bent and steered into a second angle with respect to the non-steerable tip part. The first steerable tip part may be positioned farther from the non-steerable tip part than the second steerable tip part. The first length of the first steerable tip part may be smaller than a sum of lengths of steerable tip parts other than the first steerable tip part, and the first angle may be steered so as to be larger than the second angle.

Curable silicone compositions comprising an aryl group-containing organopolysiloxane gum having a consistency of 200 to 900 as a rheological modifier are provided. Use of the curable silicone compositions comprising an aryl group-containing organopolysiloxane gum having a consistency of 200 to 900 in methods for additive manufacturing a three-dimensional silicone elastomer article are further provided.

A prosthetic device can be implanted in the corpora cavernosa of a penis with erectile dysfunction. The device being formed by two cylinders that can be inflated with a fluid. The device comprises a variable-length erectable portion formed by a chamber that can be pressurized with a low volume of fluid and is formed between an expandable membrane and an axially extendable and foldable longitudinal rib. The membrane and rib extend between a distal tip element and an intermediate connector from which a shortenable anchoring rod emerges, the rib being a single piece formed by a variable-length distal section, an intermediate section that is foldable and extendable in an axial direction, and a proximal section comprising optimized means for the continuous lateral supply of the fluid to the pressurisable chamber. The device also has an integrated unit for storing and pressurizing the fluid, which can be implanted in the scrotum.

A method of manufacturing a microstructure comprises printing a positive mold structure, filling the positive mold structure with a second material to form an elastically deformable negative mold structure, filling the negative mold structure with a third material to form the microstructure, and releasing the microstructure from the negative mold structure. Advantageously, the negative mold structure can be stretched to facilitate the release of the microstructure. For example, the microstructure comprises a chamber with capped micropillars for the generation and/or analysis of muscle tissue.